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MCID: VLV020
MIFTS: 37

Vulvar Melanoma

Categories: Cancer diseases, Reproductive diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Vulvar Melanoma

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MalaCards integrated aliases for Vulvar Melanoma:

Name: Vulvar Melanoma 12 15
Malignant Melanoma of Vulva 12 71

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2093
NCIt 50 C40329
SNOMED-CT 67 254896002
UMLS 71 C0241989
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Summaries for Vulvar Melanoma

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Disease Ontology : 12 A vulva cancer that has material basis in melanocytes.

MalaCards based summary : Vulvar Melanoma, also known as malignant melanoma of vulva, is related to amelanotic melanoma and mucosal melanoma, and has symptoms including pruritus and dysuria. An important gene associated with Vulvar Melanoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are ERK Signaling and IL-2 Pathway. Affiliated tissues include lymph node, skin and breast, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Vulvar Melanoma

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Diseases related to Vulvar Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 amelanotic melanoma 29.9 MLANA KIT
2 mucosal melanoma 29.2 NRAS NF1 KIT GNAQ GNA11
3 melanoma 29.2 NRAS MLANA KIT HRAS GNAQ GNA11
4 malignant skin fibrous histiocytoma 29.0 NRAS MLANA KIT HRAS GNAQ GNA11
5 skin melanoma 28.6 RREB1 NRAS NF1 MLANA KIT HRAS
6 acneiform dermatitis 10.2 NRAS HRAS
7 oculoectodermal syndrome 10.2 NRAS HRAS
8 large intestine adenocarcinoma 10.2 NRAS HRAS
9 benign perivascular tumor 10.2 MLANA KIT
10 skin sarcoma 10.2 MLANA KIT
11 melanocytic nevus syndrome, congenital 10.2 NRAS HRAS
12 lichen sclerosus et atrophicus 10.2
13 benign struma ovarii 10.2 NRAS HRAS
14 ovarian melanoma 10.2 NRAS MLANA
15 sensory organ benign neoplasm 10.2 NRAS MLANA
16 mucinous stomach adenocarcinoma 10.2 MLANA KIT
17 retroperitoneal sarcoma 10.2 MLANA KIT
18 spermatocytoma 10.2 KIT HRAS
19 glomangiomatosis 10.2 MLANA KIT
20 vagina sarcoma 10.2 MLANA KIT
21 thymus clear cell carcinoma 10.2 MLANA KIT
22 anus cancer 10.2 KIT HRAS
23 uterus leiomyosarcoma 10.2 MLANA KIT
24 uterine corpus sarcoma 10.2 MLANA KIT
25 uterine body mixed cancer 10.2 KIT HRAS
26 plexiform schwannoma 10.2 NF1 KIT
27 retroperitoneum carcinoma 10.2 MLANA KIT
28 bladder sarcoma 10.2 MLANA KIT
29 epithelioid cell melanoma 10.2 MLANA GNA11
30 kidney benign neoplasm 10.2 MLANA KIT
31 mixed cell type cancer 10.1 KIT HRAS
32 nasal cavity adenocarcinoma 10.1 MLANA HRAS
33 weber syndrome 10.1 GNAQ GNA11
34 nasal cavity cancer 10.1 MLANA HRAS
35 phakomatosis cesioflammea 10.1 GNAQ GNA11
36 perivascular epithelioid cell tumor 10.1 MLANA KIT
37 adult malignant schwannoma 10.1 NF1 HRAS
38 gliofibroma 10.1 NF1 KIT
39 ras-associated autoimmune leukoproliferative disorder 10.1 NRAS HRAS
40 lip and oral cavity cancer 10.1 KIT HRAS
41 chondroma 10.1 NF1 KIT
42 hypocalciuric hypercalcemia, familial, type ii 10.1 GNAQ GNA11
43 syringomyelia 10.1 NRAS NF1
44 malignant triton tumor 10.1 NF1 MLANA
45 schwannoma of twelfth cranial nerve 10.1 NF1 MLANA
46 hypoglossal nerve disease 10.1 NF1 MLANA
47 mesenchymal cell neoplasm 10.1 MLANA KIT
48 plexiform neurofibroma 10.1 NF1 KIT
49 core binding factor acute myeloid leukemia 10.1 NRAS KIT HRAS
50 vulvar disease 10.1 NRAS KIT HRAS

Graphical network of the top 20 diseases related to Vulvar Melanoma:



Diseases related to Vulvar Melanoma
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Symptoms & Phenotypes for Vulvar Melanoma

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UMLS symptoms related to Vulvar Melanoma:


pruritus, dysuria

GenomeRNAi Phenotypes related to Vulvar Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.47 HRAS
2 Decreased viability GR00055-A-2 9.47 HRAS
3 Decreased viability GR00221-A-1 9.47 HRAS KIT NF1 NRAS
4 Decreased viability GR00221-A-2 9.47 HRAS NF1
5 Decreased viability GR00221-A-3 9.47 HRAS NRAS
6 Decreased viability GR00221-A-4 9.47 NF1
7 Decreased viability GR00249-S 9.47 NF1
8 Decreased viability GR00301-A 9.47 KIT
9 Decreased viability GR00386-A-1 9.47 NF1

MGI Mouse Phenotypes related to Vulvar Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.98 GNA11 GNAQ HRAS KIT MLANA NF1
2 craniofacial MP:0005382 9.95 GNA11 GNAQ HRAS KIT NF1 NRAS
3 endocrine/exocrine gland MP:0005379 9.93 GNA11 GNAQ HRAS KIT NF1 NRAS
4 normal MP:0002873 9.87 ATF1 GNA11 GNAQ HRAS KIT NF1
5 limbs/digits/tail MP:0005371 9.8 GNA11 GNAQ KIT NF1 NRAS
6 muscle MP:0005369 9.77 GNA11 GNAQ HRAS KIT NF1
7 pigmentation MP:0001186 9.73 GNA11 GNAQ KIT MLANA NF1 NRAS
8 renal/urinary system MP:0005367 9.55 GNA11 GNAQ HRAS KIT NF1
9 respiratory system MP:0005388 9.35 GNA11 GNAQ HRAS KIT NF1
10 skeleton MP:0005390 9.17 GNA11 GNAQ HRAS KIT NF1 NRAS
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Drugs & Therapeutics for Vulvar Melanoma

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Search Clinical Trials , NIH Clinical Center for Vulvar Melanoma

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Genetic Tests for Vulvar Melanoma

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Anatomical Context for Vulvar Melanoma

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MalaCards organs/tissues related to Vulvar Melanoma:

40
Lymph Node, Skin, Breast, Placenta
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Publications for Vulvar Melanoma

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Articles related to Vulvar Melanoma:

(show top 50) (show all 141)
# Title Authors PMID Year
1
Monitoring vulvar melanoma response to combined immunotherapy and radiotherapy with in vivo reflectance confocal microscopy. 61
33569903 2021
2
Evaluation of treatment, prognostic factors, and survival in 198 vulvar melanoma patients: Implications for clinical practice. 61
33514483 2021
3
Construction and validation of a prognostic nomogram for primary vulvar melanoma: a SEER population-based study. 61
32776099 2020
4
The role of sentinel lymph node mapping in lower genital tract melanoma. 61
32744452 2020
5
Mutational Profile in Vulvar, Vaginal, and Urethral Melanomas: Review of 37 Cases With Focus on Primary Tumor Site. 61
31567539 2020
6
Vulvar melanoma: How good are we in the follow-up of high-risk women? 61
32738008 2020
7
Urethral involvement is associated with higher mortality and local recurrence in vulvar melanoma: a single institutional experience. 61
32702401 2020
8
Prognostic factors for recurrence and survival in uncommon variants of vulvar cancer. 61
33067709 2020
9
Vulvar melanoma: an analysis of prognostic factors and treatment patterns. 61
32808496 2020
10
[Analysis of treatment and prognosis of 59 cases of vulvar melanoma]. 61
32842246 2020
11
Malignant Melanoma of the Vulva and Vagina: A US Population-Based Study of 1863 Patients. 61
31784896 2020
12
Thin vulvar melanoma: a challenging diagnosis. Dermoscopic features of a case series. 61
31389062 2020
13
[Case study of vulvar malignant melanoma conducted at the Cinquantenaire General Hospital in Lubumbashi]. 61
32849979 2020
14
Primary malignant melanomas of the female lower genital tract: clinicopathological characteristics and management. 61
33414983 2020
15
Successful treatment with avapritinib in patient with mucosal metastatic melanoma. 61
32821296 2020
16
Vulvar cancer: surgical management and survival trends in a low resource setting. 61
32372283 2020
17
Vulvar malignancies: an interdisciplinary perspective. 61
31829526 2019
18
Positron emission tomography as an adjuvant diagnostic test in the evaluation of checkpoint inhibitor-associated acute interstitial nephritis. 61
31864416 2019
19
Ringlike pattern as a dermatoscopy sign for vulvar melanosis does not preclude synchronous existence of vulvar melanoma. 61
30897233 2019
20
Vulvar melanoma: management of primary disease and repeated recurrences. 61
31196869 2019
21
Robot-assisted Sentinel Lymph Node Mapping and Inguinal Lymph Node Dissection Using Near-infrared Fluorescence in Vulvar Cancer. 61
30959199 2019
22
Melanoma of the Vulva and Vagina: Surgical Management and Outcomes Based on a Clinicopathologic Reviewof 68 Cases. 61
30391279 2019
23
Association of Vulvar Melanoma with Lichen Sclerosus. 61
30521058 2019
24
Recurrent vulvar melanoma in a patient with neurofibromatosis and gastrointestinal stromal tumour. 61
30665926 2019
25
Recurrent vulvar melanoma invading urethra. Clinical case and literature review. 61
29888188 2018
26
Vulvar Melanoma with Isolated Metastasis to the Extraocular Muscles: Case Report and Brief Literature Review. 61
29848740 2018
27
Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget's disease with curative responses. 61
29914570 2018
28
Raised vulvar lesions: be aware! 61
29785335 2018
29
Prognostic role of tumoral PDL1 expression and peritumoral FoxP3+ lymphocytes in vulvar melanomas. 61
29307625 2018
30
[Laparoscopic anterior pelvic exenteration in a patient with locally advanced melanoma]. 61
28027809 2017
31
KIT mutations and CD117 overexpression are markers of better progression-free survival in vulvar melanomas. 61
28734009 2017
32
Vulvar melanoma: relevant aspects in therapeutic management. 61
29186258 2017
33
Tumor Thickness and Mitotic Rate Robustly Predict Melanoma-Specific Survival in Patients with Primary Vulvar Melanoma: A Retrospective Review of 100 Cases. 61
27864417 2017
34
Satellitosis and CD117 immunohistochemical expression correlates with poor outcome in thick vulvar melanoma. 61
27377140 2017
35
Enhanced skin toxicity with concurrent ipilimumab and radiation in vaginal/vulvar melanoma: a case report and literature review. 61
30363303 2017
36
Prognostic Factors of Recurrence and Survival in Vulvar Melanoma: Subgroup Analysis of the VULvar CANcer Study. 61
27465889 2016
37
Rare vulvar malignancies; incidence, treatment and survival in the Netherlands. 61
27126004 2016
38
Vulvar melanoma presenting as postmenopausal bleeding: a case report. 61
29894082 2016
39
Vulvar Melanoma Associated with Lichen Sclerosus in a Child: Case Report and Literature Review. 61
27040997 2016
40
Surgical pathology, management and outcome in the vulvar melanoma associated with abdominal mass - a case report. 61
28174807 2016
41
Malignant Melanoma of Vulva and Vagina: A Histomorphological Review and Mutation Analysis--A Single-Center Study. 61
26225944 2015
42
Amelanotic vulvar melanoma: a case report. 61
25993407 2015
43
Vulvar melanoma: a 33 years single Italian center experience. 61
25236321 2015
44
Vulvar melanoma with urethral invasion and bladder metastases - a case report and review of the literature. 61
25861315 2015
45
[Vulvar melanoma]. 61
25909143 2015
46
Gynaecological Screening for Cervical and Vulvar Malignancies in a Cohort of Systemic Sclerosis Patients: Our Experience and Review of the Literature. 61
26557142 2015
47
Vulvar nevi, melanosis, and melanoma: an epidemiologic, clinical, and histopathologic review. 61
25267379 2014
48
Stereotactic radiosurgery (SRS) with volumetric modulated arc therapy (VMAT): interim results of a multi-arm phase I trial (DESTROY-2). 61
25175042 2014
49
Volumetric intensity modulated arc therapy for stereotactic body radiosurgery in oligometastatic breast and gynecological cancers: feasibility and clinical results. 61
25175950 2014
50
NRAS mutations are more prevalent than KIT mutations in melanoma of the female urogenital tract--a study of 24 cases from the Netherlands. 61
24802725 2014
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Variations for Vulvar Melanoma

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Expression for Vulvar Melanoma

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Search GEO for disease gene expression data for Vulvar Melanoma.
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Pathways for Vulvar Melanoma

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Pathways related to Vulvar Melanoma according to GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.64 NRAS NF1 KIT HRAS GNA11 ATF1
2
IL-2 Pathway 63
Show member pathways
 13.05 NRAS HRAS GNAQ GNA11 ATF1
3
Phospholipase-C Pathway 63
Show member pathways
 12.92 NRAS KIT HRAS GNA11
4
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.91 NRAS HRAS GNAQ GNA11
5
p70S6K Signaling 63
Show member pathways
 12.9 NRAS KIT HRAS GNA11
6
TNFR1 Pathway 63
Show member pathways
 12.88 NRAS HRAS GNAQ GNA11 ATF1
7
DAG and IP3 signaling 65
Show member pathways
 12.88 NRAS HRAS GNAQ GNA11 ATF1
8
Human cytomegalovirus infection 36
Show member pathways
 12.79 NRAS HRAS GNAQ GNA11
9
CCR5 Pathway in Macrophages 63
Show member pathways
 12.73 NRAS HRAS GNAQ GNA11
10
Circadian entrainment 36
Show member pathways
 12.63 NRAS HRAS GNAQ GNA11
11
MAPK signaling pathway 36 1
12.61 NRAS NF1 KIT HRAS
12
Pathways in cancer 36
12.6 NRAS KIT HRAS GNAQ GNA11
13
Ras signaling pathway 36
Show member pathways
 12.5 NRAS NF1 KIT HRAS GNAQ
14
Aldosterone synthesis and secretion 36
Show member pathways
 12.5 NRAS KIT HRAS GNAQ GNA11 ATF1
15
Relaxin signaling pathway 36
Show member pathways
 12.49 NRAS HRAS GNAQ GNA11
16
Development Endothelin-1/EDNRA signaling 23
Show member pathways
 12.45 NRAS HRAS GNAQ GNA11
17
Oxytocin signaling pathway 36
Show member pathways
 12.3 NRAS HRAS GNAQ GNA11
18
Phospholipase D signaling pathway 36
Show member pathways
 12.28 NRAS KIT HRAS
19
Toll Comparative Pathway 63
Show member pathways
 12.19 HRAS GNA11 ATF1
20
Development A3 receptor signaling 23
Show member pathways
 12.19 HRAS GNAQ GNA11
21
Paradoxical activation of RAF signaling by kinase inactive BRAF 65
Show member pathways
 12.16 NRAS NF1 HRAS
22
Apelin signaling pathway 36
11.97 NRAS HRAS GNAQ
23
Oncogenic MAPK signaling 65
Show member pathways
 11.96 NRAS NF1 HRAS
24
Signaling by PTK6 65
Show member pathways
 11.93 NRAS NF1 HRAS
25
Development A2B receptor- action via G-protein alpha s 23
Show member pathways
 11.9 HRAS GNAQ GNA11
26
Ceramide Pathway 63
Show member pathways
 11.89 NRAS HRAS ATF1
27
Translation Translation regulation by Alpha-1 adrenergic receptors 23
Show member pathways
 11.88 HRAS GNAQ GNA11
28
Sphingolipid signaling pathway 36
11.87 NRAS HRAS GNAQ
29
Development Angiotensin activation of ERK 23
Show member pathways
 11.86 NRAS KIT HRAS GNAQ GNA11 ATF1
30
Serotonergic synapse 36
11.85 NRAS HRAS GNAQ
31
UVA-Induced MAPK Signaling 63
Show member pathways
 11.84 NRAS HRAS GNAQ GNA11
32
Glioblastoma Multiforme 63
11.82 NRAS NF1 HRAS
33
Long-term potentiation 36
Show member pathways
 11.8 NRAS HRAS GNAQ
34
MAP Kinase Signaling 4
11.76 NRAS NF1 HRAS GNAQ
35
VEGF Pathway (Tocris) 60
Show member pathways
 11.66 NRAS KIT HRAS
36
Gap junction 36
11.57 NRAS HRAS GNAQ GNA11
37
Central carbon metabolism in cancer 36
11.55 NRAS KIT HRAS
38
G-protein signaling_RhoA regulation pathway 23
11.54 NRAS HRAS GNAQ GNA11
39
LPA receptor mediated events 1
11.5 HRAS GNAQ GNA11
40
Interleukin-11 Signaling Pathway 1
11.37 HRAS ATF1
41
Vemurafenib Pathway, Pharmacodynamics 60
11.36 NRAS HRAS
42
Aryl Hydrocarbon Receptor 1
11.35 NRAS NF1 HRAS
43
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 23
11.31 GNAQ GNA11
44
Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics 60
11.29 NRAS HRAS
45
GnRH secretion 36
11.26 NRAS HRAS GNAQ GNA11
46
CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF) 23
11.25 GNAQ GNA11
47
Arf6 signaling events 1
11.24 GNAQ GNA11
48
Syndecan-2-mediated signaling events 1
11.22 NF1 HRAS
49
BDNF-TrkB Signaling 1
11.22 NRAS HRAS
50
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 1
11.18 NRAS HRAS
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GO Terms for Vulvar Melanoma

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Cellular components related to Vulvar Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heterotrimeric G-protein complex GO:0005834 8.62 GNAQ GNA11

Biological processes related to Vulvar Melanoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.91 NRAS NF1 KIT HRAS GNAQ GNA11
2 pigmentation GO:0043473 9.49 NF1 KIT
3 positive regulation of DNA replication GO:0045740 9.48 HRAS ATF1
4 action potential GO:0001508 9.46 GNAQ GNA11
5 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.4 GNAQ GNA11
6 positive regulation of phospholipase C activity GO:0010863 9.37 KIT HRAS
7 developmental pigmentation GO:0048066 9.32 KIT GNA11
8 phototransduction, visible light GO:0007603 9.26 GNAQ GNA11
9 MAPK cascade GO:0000165 9.26 NRAS NF1 KIT HRAS
10 entrainment of circadian clock GO:0009649 9.16 GNAQ GNA11
11 Ras protein signal transduction GO:0007265 8.92 RREB1 NRAS NF1 HRAS

Molecular functions related to Vulvar Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 NRAS HRAS GNAQ GNA11
2 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNAQ GNA11
3 guanyl nucleotide binding GO:0019001 9.26 GNAQ GNA11
4 GTPase activity GO:0003924 9.26 NRAS HRAS GNAQ GNA11
5 type 2A serotonin receptor binding GO:0031826 8.62 GNAQ GNA11
Sources

Sources for Vulvar Melanoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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