MCID: VLV030
MIFTS: 27

Vulvar Proximal-Type Epithelioid Sarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Proximal-Type Epithelioid Sarcoma

MalaCards integrated aliases for Vulvar Proximal-Type Epithelioid Sarcoma:

Name: Vulvar Proximal-Type Epithelioid Sarcoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7491
NCIt 50 C40319
UMLS 70 C1520093

Summaries for Vulvar Proximal-Type Epithelioid Sarcoma

MalaCards based summary : Vulvar Proximal-Type Epithelioid Sarcoma is related to spindle cell sarcoma and epithelioid sarcoma. An important gene associated with Vulvar Proximal-Type Epithelioid Sarcoma is SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1), and among its related pathways/superpathways are Cytoskeletal Signaling and Keratinization. Affiliated tissues include breast, lung and thymus, and related phenotype is Reduced mammosphere formation.

Related Diseases for Vulvar Proximal-Type Epithelioid Sarcoma

Diseases related to Vulvar Proximal-Type Epithelioid Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 437)
# Related Disease Score Top Affiliating Genes
1 spindle cell sarcoma 30.4 VIM KRT7 CD34
2 epithelioid sarcoma 29.6 VIM SYP SMARCB1 KRT7 CD34
3 central epithelioid sarcoma 26.0 VIM TNFRSF8 SYP SMARCB1 PMEL MME
4 central nervous system angiosarcoma 10.5 SMARCB1 CD34
5 vulvar sarcoma 10.4 SMARCB1 CD34
6 alk+ histiocytosis 10.4 CD207 CD1A
7 plexiform schwannoma 10.4 SMARCB1 CD34
8 predominantly cortical thymoma 10.4 CD1E CD1A
9 erythema elevatum diutinum 10.4 CD34 CD1E
10 angiomyoma 10.4 MB CD34
11 thyroid angiosarcoma 10.4 KRT20 CD34
12 pediatric liposarcoma 10.4 VIM CD34
13 tolosa-hunt syndrome 10.4 CD1E CD1A
14 retroperitoneal sarcoma 10.4 SMARCB1 CD34
15 cellular schwannoma 10.4 SMARCB1 CD34
16 dendritic cell thymoma 10.4 CD1E CD1A
17 multifocal motor neuropathy 10.3 CD1E CD1A
18 cutaneous leiomyosarcoma 10.3 VIM CD34
19 gallbladder leiomyosarcoma 10.3 MB CD34
20 thymus lipoma 10.3 MB KRT20
21 immune system organ benign neoplasm 10.3 MB KRT20
22 chondroid chordoma 10.3 VIM SMARCB1
23 multicentric reticulohistiocytosis 10.3 VIM CD1E
24 spermatic cord cancer 10.3 KRT5 CD34
25 thymus adenocarcinoma 10.3 KRT5 KRT20
26 epithelioid malignant peripheral nerve sheath tumor 10.3 SMARCB1 CD34
27 colon leiomyosarcoma 10.3 KRT5 CD34
28 angiolipoma 10.3 VIM CD34
29 testicular fibroma 10.3 KRT5 CD34
30 spindle cell lipoma 10.3 VIM CD34
31 oral hairy leukoplakia 10.3 CD1E CD1A
32 skin sarcoidosis 10.3 CD1C CD1B
33 ovarian solid teratoma 10.3 TNFRSF8 CD34
34 breast leiomyoma 10.3 MME CD34
35 breast myofibroblastoma 10.3 MME CD34
36 neurilemmoma 10.3 VIM SMARCB1 CD34
37 juvenile xanthogranuloma 10.3 PMEL CD1E CD1A
38 pacinian tumor 10.3 MME CD34
39 mucocele of appendix 10.3 MME CD34
40 malignant mesenchymoma 10.3 MB CD34
41 mixed type thymoma 10.3 CD1E CD1B CD1A
42 encapsulated thymoma 10.3 CD1E CD1B CD1A
43 sphenoid sinusitis 10.3 CD1E CD1B CD1A
44 epithelial malignant thymoma 10.3 CD1E CD1B CD1A
45 bladder lymphoma 10.3 MME KRT20
46 necrobiosis lipoidica 10.3 CD1E CD1B CD1A
47 inflammatory liposarcoma 10.3 MME CD34
48 liposarcoma of bone 10.2 TNFRSF8 CD34
49 cervical polyp 10.2 MME CD34
50 intravenous leiomyomatosis 10.2 MME CD34

Graphical network of the top 20 diseases related to Vulvar Proximal-Type Epithelioid Sarcoma:



Diseases related to Vulvar Proximal-Type Epithelioid Sarcoma

Symptoms & Phenotypes for Vulvar Proximal-Type Epithelioid Sarcoma

GenomeRNAi Phenotypes related to Vulvar Proximal-Type Epithelioid Sarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CD1A CD1D CD34 KRT18 KRT7 SMARCB1

Drugs & Therapeutics for Vulvar Proximal-Type Epithelioid Sarcoma

Search Clinical Trials , NIH Clinical Center for Vulvar Proximal-Type Epithelioid Sarcoma

Genetic Tests for Vulvar Proximal-Type Epithelioid Sarcoma

Anatomical Context for Vulvar Proximal-Type Epithelioid Sarcoma

MalaCards organs/tissues related to Vulvar Proximal-Type Epithelioid Sarcoma:

40
Breast, Lung, Thymus, Skin, Appendix, Bone, Kidney

Publications for Vulvar Proximal-Type Epithelioid Sarcoma

Articles related to Vulvar Proximal-Type Epithelioid Sarcoma:

# Title Authors PMID Year
1
Vulvar "proximal-type" epithelioid sarcoma: report of a case and review of the literature. 61
23886403 2013
2
["Proximal type" epithelioid sarcoma of the vulva: differential diagnosis with other extrarenal rhabdoid tumors]. 61
16259280 2005

Variations for Vulvar Proximal-Type Epithelioid Sarcoma

Expression for Vulvar Proximal-Type Epithelioid Sarcoma

Search GEO for disease gene expression data for Vulvar Proximal-Type Epithelioid Sarcoma.

Pathways for Vulvar Proximal-Type Epithelioid Sarcoma

Pathways related to Vulvar Proximal-Type Epithelioid Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.29 VIM KRT7 KRT5 KRT20 KRT18
2
Show member pathways
12.19 KRT7 KRT5 KRT20 KRT18
3 11.95 CD1E CD1D CD1C CD1B CD1A
4 11.79 CD34 CD1D CD1C CD1B CD1A
5
Show member pathways
11.7 VIM KRT7 KRT5 KRT18
6 11.56 CD1E CD1D CD1C CD1B CD1A
7 11.3 MME CD34 CD207 CD1D CD1C CD1A
8 11.16 MME CD34 CD1E CD1D CD1C CD1B

GO Terms for Vulvar Proximal-Type Epithelioid Sarcoma

Cellular components related to Vulvar Proximal-Type Epithelioid Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.87 PMEL MME CD34 CD1E CD1D CD1C
2 endosome membrane GO:0010008 9.67 CD1D CD1C CD1B CD1A
3 lysosome GO:0005764 9.65 CD34 CD1E CD1D CD1C CD1B
4 endosome GO:0005768 9.63 PMEL CD1E CD1D CD1C CD1B CD1A
5 keratin filament GO:0045095 9.58 KRT7 KRT5 KRT18
6 intermediate filament GO:0005882 9.35 VIM KRT7 KRT5 KRT20 KRT18
7 external side of plasma membrane GO:0009897 9.17 KRT18 CD34 CD1E CD1D CD1C CD1B

Biological processes related to Vulvar Proximal-Type Epithelioid Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.8 CD1E CD1D CD1C CD1B CD1A
2 keratinization GO:0031424 9.67 KRT7 KRT5 KRT20 KRT18
3 regulation of immune response GO:0050776 9.65 CD34 CD1D CD1C CD1B CD1A
4 cornification GO:0070268 9.62 KRT7 KRT5 KRT20 KRT18
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
6 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
7 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Vulvar Proximal-Type Epithelioid Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
2 structural constituent of cytoskeleton GO:0005200 9.5 VIM KRT5 KRT20
3 scaffold protein binding GO:0097110 9.43 VIM KRT5 KRT18
4 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
5 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Vulvar Proximal-Type Epithelioid Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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