MCID: VLV038
MIFTS: 32

Vulvar Sarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Sarcoma

MalaCards integrated aliases for Vulvar Sarcoma:

Name: Vulvar Sarcoma 12 15
Sarcoma of Vulva 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2096
NCIt 50 C40317
UMLS 73 C0238525

Summaries for Vulvar Sarcoma

Disease Ontology : 12 A vulva cancer that has_material_basis in connective tissue.

MalaCards based summary : Vulvar Sarcoma, also known as sarcoma of vulva, is related to vulvar leiomyosarcoma and epithelioid sarcoma. An important gene associated with Vulvar Sarcoma is GPX1 (Glutathione Peroxidase 1), and among its related pathways/superpathways are NF-kappaB Signaling and Chromatin Regulation / Acetylation. Affiliated tissues include cervix, myeloid and skin, and related phenotypes are cellular and hematopoietic system

Related Diseases for Vulvar Sarcoma

Diseases related to Vulvar Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 vulvar leiomyosarcoma 31.3 AR GPX1 H2AFX PTPRC
2 epithelioid sarcoma 29.9 KRT7 SMARCB1
3 vulvar alveolar soft part sarcoma 11.2
4 vulvar liposarcoma 11.2
5 rhabdoid cancer 10.2 EWSR1 SMARCB1
6 extraosseous chondrosarcoma 10.2 EWSR1 SMARCB1
7 synovium cancer 10.2 EWSR1 SMARCB1
8 collecting duct carcinoma 10.2 KRT7 SMARCB1
9 epithelial-myoepithelial carcinoma 10.1 KRT7 SMARCB1
10 epidural neoplasm 10.1 PTPRC SMARCB1
11 chondrosarcoma, extraskeletal myxoid 10.1 EWSR1 SMARCB1
12 atypical choroid plexus papilloma 10.1 KRT7 TWIST1
13 extraskeletal ewing sarcoma 10.1 EWSR1 PTPRC
14 bone epithelioid hemangioma 10.1 CD34 EWSR1
15 sweat gland disease 10.1 EWSR1 KRT7
16 spindle cell liposarcoma 10.1 CD34 SMARCB1
17 bone ewing's sarcoma 10.1 EWSR1 PTPRC
18 interstitial emphysema 10.1 CD34 TWIST1
19 oncocytic breast carcinoma 10.1 AR KRT7
20 thymus lipoma 10.1 KRT7 PTPRC
21 olfactory neuroblastoma 10.1 EWSR1 PTPRC
22 mucinous cystadenocarcinoma 10.1 KRT7 PTPRC
23 meibomian cyst 10.1 AR KRT7
24 corneal abscess 10.1 AR KRT7
25 eccrine adenocarcinoma 10.1 CD34 KRT7
26 immune system organ benign neoplasm 10.1 KRT7 PTPRC
27 extracutaneous mastocytoma 10.1 CD34 PTPRC
28 paget disease, extramammary 10.1 AR KRT7
29 liver inflammatory pseudotumor 10.1 CD34 PTPRC
30 glomeruloid hemangioma 10.1 CD34 PTPRC
31 alveoli adenoma 10.1 CD34 KRT7
32 conventional fibrosarcoma 10.1 CD34 PTPRC
33 chronic monocytic leukemia 10.1 CD34 PTPRC
34 infiltrative basal cell carcinoma 10.1 AR KRT7
35 rhabdoid tumor predisposition syndrome 1 10.1 PTPRC SMARCB1
36 skin sarcoma 10.1 CD34 EWSR1
37 sarcoma 10.1
38 nervous system benign neoplasm 10.1 CD34 SMARCB1
39 peritoneal benign neoplasm 10.1 AR CD34
40 diffuse peritoneal leiomyomatosis 10.1 AR CD34
41 intraneural perineurioma 10.1 CD34 KRT7
42 reticulohistiocytic granuloma 10.1 CD34 PTPRC
43 cystitis cystica 10.0 AR KRT7
44 kidney rhabdoid cancer 10.0 EWSR1 PTPRC SMARCB1
45 nephrogenic adenofibroma 10.0 CD34 KRT7
46 myoepithelioma 10.0 EWSR1 PTPRC SMARCB1
47 muscle cancer 10.0 CD34 EWSR1
48 intestinal obstruction 10.0 KRT7 TWIST1
49 mesenchymal cell neoplasm 10.0 CD34 EWSR1 SMARCB1
50 connective tissue cancer 10.0 CD34 EWSR1 SMARCB1

Graphical network of the top 20 diseases related to Vulvar Sarcoma:



Diseases related to Vulvar Sarcoma

Symptoms & Phenotypes for Vulvar Sarcoma

MGI Mouse Phenotypes related to Vulvar Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 AR CD34 GPX1 H2AFX KRT7 PTPRC
2 hematopoietic system MP:0005397 9.8 AR CD34 GPX1 H2AFX PTPRC SMARCB1
3 homeostasis/metabolism MP:0005376 9.76 AR CD34 GPX1 H2AFX KRT7 PTPRC
4 digestive/alimentary MP:0005381 9.72 AR GPX1 PTPRC SMARCB1 TWIST1
5 immune system MP:0005387 9.5 AR CD34 GPX1 H2AFX PTPRC SMARCB1
6 neoplasm MP:0002006 9.02 AR CD34 H2AFX PTPRC SMARCB1

Drugs & Therapeutics for Vulvar Sarcoma

Search Clinical Trials , NIH Clinical Center for Vulvar Sarcoma

Genetic Tests for Vulvar Sarcoma

Anatomical Context for Vulvar Sarcoma

MalaCards organs/tissues related to Vulvar Sarcoma:

41
Cervix, Myeloid, Skin, Kidney, Liver, Bone, Thymus

Publications for Vulvar Sarcoma

Articles related to Vulvar Sarcoma:

# Title Authors Year
1
Clear cell sarcoma of vulva. A case report. ( 27869448 )
2016
2
Myeloid Sarcoma Of Vulva: A Short Update. ( 27408359 )
2016
3
Primary Ewing sarcoma of vulva, confirmed with molecular cytogenetic analysis: A rare case report with diagnostic and treatment implications. ( 26275259 )
2015
4
A rare association between neurofibromatosis type 1 and vulvar sarcoma. ( 24819769 )
2014
5
Primary Ewing's sarcoma of vulva: a case report and a review of the literature. ( 23106919 )
2013
6
Sarcoma of vulva, vagina and ovary. ( 21816677 )
2011
7
Epithelioid sarcoma of vulva: a case report and review of the literature. ( 15579921 )
2004
8
Vulvar sarcoma: clinical implications. ( 7821491 )
1994
9
Vulvar sarcoma: a report of four cases. ( 1526519 )
1992

Variations for Vulvar Sarcoma

Expression for Vulvar Sarcoma

Search GEO for disease gene expression data for Vulvar Sarcoma.

Pathways for Vulvar Sarcoma

Pathways related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.95 CD34 GPX1 PTPRC
2 11.33 AR EWSR1 H2AFX SMARCB1
3 10.88 CD34 PTPRC
4 10.64 AR TWIST1

GO Terms for Vulvar Sarcoma

Cellular components related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.13 AR H2AFX SMARCB1
2 XY body GO:0001741 8.62 H2AFX SMARCB1

Biological processes related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tumor necrosis factor production GO:0032760 9.16 PTPRC TWIST1
2 negative regulation of tumor necrosis factor production GO:0032720 8.96 CD34 TWIST1
3 response to gamma radiation GO:0010332 8.62 GPX1 PTPRC

Sources for Vulvar Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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