MCID: VLV038
MIFTS: 30

Vulvar Sarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Sarcoma

MalaCards integrated aliases for Vulvar Sarcoma:

Name: Vulvar Sarcoma 12 15
Sarcoma of Vulva 12 74
Vulva Sarcoma 17

Classifications:



External Ids:

Disease Ontology 12 DOID:2096
NCIt 51 C40317
UMLS 74 C0238525

Summaries for Vulvar Sarcoma

Disease Ontology : 12 A vulva cancer that has_material_basis in connective tissue.

MalaCards based summary : Vulvar Sarcoma, also known as sarcoma of vulva, is related to vulvar leiomyosarcoma and epithelioid sarcoma. An important gene associated with Vulvar Sarcoma is GPX1 (Glutathione Peroxidase 1), and among its related pathways/superpathways are NF-kappaB Signaling and Chromatin Regulation / Acetylation. Affiliated tissues include ovary and myeloid, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Vulvar Sarcoma

Diseases related to Vulvar Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 vulvar leiomyosarcoma 31.1 AR GPX1 H2AFX PTPRC
2 epithelioid sarcoma 30.0 KRT7 SMARCB1
3 vulvar alveolar soft part sarcoma 11.2
4 vulvar liposarcoma 11.2
5 rhabdoid cancer 10.3 EWSR1 SMARCB1
6 extraosseous chondrosarcoma 10.3 EWSR1 SMARCB1
7 synovium cancer 10.3 EWSR1 SMARCB1
8 collecting duct carcinoma 10.2 KRT7 SMARCB1
9 epithelial-myoepithelial carcinoma 10.2 KRT7 SMARCB1
10 epidural neoplasm 10.2 PTPRC SMARCB1
11 spindle cell liposarcoma 10.2 CD34 SMARCB1
12 extraskeletal ewing sarcoma 10.2 EWSR1 PTPRC
13 bone epithelioid hemangioma 10.2 CD34 EWSR1
14 sweat gland disease 10.2 EWSR1 KRT7
15 chondrosarcoma, extraskeletal myxoid 10.2 EWSR1 SMARCB1
16 oncocytic breast carcinoma 10.2 AR KRT7
17 thymus lipoma 10.2 KRT7 PTPRC
18 mucinous cystadenocarcinoma 10.2 KRT7 PTPRC
19 bone ewing's sarcoma 10.1 EWSR1 PTPRC
20 meibomian cyst 10.1 AR KRT7
21 corneal abscess 10.1 AR KRT7
22 immune system organ benign neoplasm 10.1 KRT7 PTPRC
23 eccrine adenocarcinoma 10.1 CD34 KRT7
24 olfactory neuroblastoma 10.1 EWSR1 PTPRC
25 rhabdoid tumor predisposition syndrome 1 10.1 PTPRC SMARCB1
26 extracutaneous mastocytoma 10.1 CD34 PTPRC
27 paget disease, extramammary 10.1 AR KRT7
28 liver inflammatory pseudotumor 10.1 CD34 PTPRC
29 glomeruloid hemangioma 10.1 CD34 PTPRC
30 alveoli adenoma 10.1 CD34 KRT7
31 conventional fibrosarcoma 10.1 CD34 PTPRC
32 chronic monocytic leukemia 10.1 CD34 PTPRC
33 infiltrative basal cell carcinoma 10.1 AR KRT7
34 skin sarcoma 10.1 CD34 EWSR1
35 peritoneal benign neoplasm 10.1 AR CD34
36 sarcoma 10.1
37 diffuse peritoneal leiomyomatosis 10.1 AR CD34
38 reticulohistiocytic granuloma 10.1 CD34 PTPRC
39 intraneural perineurioma 10.1 CD34 KRT7
40 cystitis cystica 10.1 AR KRT7
41 nephrogenic adenofibroma 10.1 CD34 KRT7
42 kidney rhabdoid cancer 10.0 EWSR1 PTPRC SMARCB1
43 myoepithelioma 10.0 EWSR1 PTPRC SMARCB1
44 muscle cancer 10.0 CD34 EWSR1
45 mesenchymal cell neoplasm 10.0 CD34 EWSR1 SMARCB1
46 connective tissue cancer 10.0 CD34 EWSR1 SMARCB1
47 nervous system cancer 10.0 CD34 EWSR1 SMARCB1
48 small cell carcinoma 10.0 KRT7 PTPRC
49 spindle cell synovial sarcoma 10.0 CD34 KRT7 SMARCB1
50 adenosquamous carcinoma 10.0 AR KRT7

Graphical network of the top 20 diseases related to Vulvar Sarcoma:



Diseases related to Vulvar Sarcoma

Symptoms & Phenotypes for Vulvar Sarcoma

MGI Mouse Phenotypes related to Vulvar Sarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.92 AR CD34 GPX1 H2AFX KRT7 PTPRC
2 homeostasis/metabolism MP:0005376 9.81 AR CD34 GPX1 H2AFX KRT7 PTPRC
3 hematopoietic system MP:0005397 9.8 AR CD34 GPX1 H2AFX PTPRC SMARCB1
4 immune system MP:0005387 9.5 AR CD34 GPX1 H2AFX PTPRC SMARCB1
5 neoplasm MP:0002006 9.1 AR CD34 H2AFX PTPRC SMARCB1 SOD2

Drugs & Therapeutics for Vulvar Sarcoma

Search Clinical Trials , NIH Clinical Center for Vulvar Sarcoma

Genetic Tests for Vulvar Sarcoma

Anatomical Context for Vulvar Sarcoma

MalaCards organs/tissues related to Vulvar Sarcoma:

42
Ovary, Myeloid

Publications for Vulvar Sarcoma

Articles related to Vulvar Sarcoma:

# Title Authors Year
1
Clear cell sarcoma of vulva. A case report. ( 27869448 )
2016
2
Myeloid Sarcoma Of Vulva: A Short Update. ( 27408359 )
2016
3
Primary Ewing sarcoma of vulva, confirmed with molecular cytogenetic analysis: A rare case report with diagnostic and treatment implications. ( 26275259 )
2015
4
A rare association between neurofibromatosis type 1 and vulvar sarcoma. ( 24819769 )
2014
5
Primary Ewing's sarcoma of vulva: a case report and a review of the literature. ( 23106919 )
2013
6
Sarcoma of vulva, vagina and ovary. ( 21816677 )
2011
7
Epithelioid sarcoma of vulva: a case report and review of the literature. ( 15579921 )
2004
8
Vulvar sarcoma: clinical implications. ( 7821491 )
1994
9
Vulvar sarcoma: a report of four cases. ( 1526519 )
1992

Variations for Vulvar Sarcoma

Expression for Vulvar Sarcoma

Search GEO for disease gene expression data for Vulvar Sarcoma.

Pathways for Vulvar Sarcoma

Pathways related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.01 CD34 GPX1 PTPRC
2 11.33 AR EWSR1 H2AFX SMARCB1
3
Show member pathways
11 GPX1 SOD2
4 10.88 CD34 PTPRC
5 10.45 GPX1 SOD2

GO Terms for Vulvar Sarcoma

Cellular components related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.13 AR H2AFX SMARCB1
2 XY body GO:0001741 8.62 H2AFX SMARCB1

Biological processes related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to gamma radiation GO:0010332 8.96 GPX1 PTPRC
2 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 8.62 GPX1 SOD2

Sources for Vulvar Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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