MCID: VLV038
MIFTS: 27

Vulvar Sarcoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Sarcoma

MalaCards integrated aliases for Vulvar Sarcoma:

Name: Vulvar Sarcoma 12 15
Sarcoma of Vulva 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2096
NCIt 50 C40317
SNOMED-CT 68 254897006
UMLS 73 C0238525

Summaries for Vulvar Sarcoma

MalaCards based summary : Vulvar Sarcoma, also known as sarcoma of vulva, is related to vulvar alveolar soft part sarcoma and extraosseous chondrosarcoma. An important gene associated with Vulvar Sarcoma is GPX1 (Glutathione Peroxidase 1), and among its related pathways/superpathways are NF-kappaB Signaling and Chromatin Regulation / Acetylation. Affiliated tissues include myeloid, and related phenotypes are cellular and hematopoietic system

Related Diseases for Vulvar Sarcoma

Diseases related to Vulvar Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 vulvar alveolar soft part sarcoma 11.1
2 extraosseous chondrosarcoma 10.6 EWSR1 SMARCB1
3 collecting duct carcinoma 10.5 KRT7 SMARCB1
4 epithelial-myoepithelial carcinoma 10.5 KRT7 SMARCB1
5 epidural neoplasm 10.4 PTPRC SMARCB1
6 atypical choroid plexus papilloma 10.4 KRT7 TWIST1
7 extraskeletal ewing sarcoma 10.4 EWSR1 PTPRC
8 bone epithelioid hemangioma 10.4 CD34 EWSR1
9 spindle cell liposarcoma 10.4 CD34 SMARCB1
10 olfactory neuroblastoma 10.4 EWSR1 PTPRC
11 rhabdoid cancer 10.4 PTPRC SMARCB1
12 mucinous cystadenocarcinoma 10.4 KRT7 PTPRC
13 chondrosarcoma, extraskeletal myxoid 10.4 EWSR1 SMARCB1
14 bone ewing's sarcoma 10.3 EWSR1 PTPRC
15 interstitial emphysema 10.3 CD34 TWIST1
16 oncocytic breast carcinoma 10.3 AR KRT7
17 eccrine adenocarcinoma 10.3 CD34 KRT7
18 apocrine adenocarcinoma 10.3 AR KRT7
19 immune system organ benign neoplasm 10.3 KRT7 PTPRC
20 myoepithelioma 10.3 EWSR1 SMARCB1
21 thymus lipoma 10.3 KRT7 PTPRC
22 meibomian cyst 10.3 AR KRT7
23 corneal abscess 10.3 AR KRT7
24 epithelioid sarcoma 10.3 KRT7 SMARCB1
25 extracutaneous mastocytoma 10.3 CD34 PTPRC
26 liver inflammatory pseudotumor 10.3 CD34 PTPRC
27 glomeruloid hemangioma 10.3 CD34 PTPRC
28 paget disease, extramammary 10.3 AR KRT7
29 diffuse cutaneous mastocytosis 10.3 CD34 PTPRC
30 sarcomatoid squamous cell skin carcinoma 10.3 CD34 PTPRC
31 chronic monocytic leukemia 10.3 CD34 PTPRC
32 infiltrative basal cell carcinoma 10.3 AR KRT7
33 conventional fibrosarcoma 10.3 CD34 PTPRC
34 skin sarcoma 10.2 CD34 EWSR1
35 intraneural perineurioma 10.2 CD34 KRT7
36 kidney rhabdoid cancer 10.2 EWSR1 PTPRC SMARCB1
37 reticulohistiocytic granuloma 10.1 CD34 PTPRC
38 cystitis cystica 10.1 AR KRT7
39 nephrogenic adenofibroma 10.1 CD34 KRT7
40 sweat gland cancer 10.1 AR KRT7
41 synovium cancer 10.1 CD34 EWSR1 SMARCB1
42 mesenchymal cell neoplasm 10.1 CD34 EWSR1 SMARCB1
43 connective tissue cancer 10.1 CD34 EWSR1 SMARCB1
44 nervous system cancer 10.1 CD34 EWSR1 SMARCB1
45 muscle cancer 10.0 CD34 EWSR1
46 intestinal obstruction 10.0 KRT7 TWIST1
47 spindle cell synovial sarcoma 10.0 CD34 KRT7 SMARCB1
48 organ system benign neoplasm 10.0 CD34 KRT7 SMARCB1
49 sarcoma 10.0
50 cell type cancer 9.9 CD34 EWSR1 KRT7

Graphical network of the top 20 diseases related to Vulvar Sarcoma:



Diseases related to Vulvar Sarcoma

Symptoms & Phenotypes for Vulvar Sarcoma

MGI Mouse Phenotypes related to Vulvar Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 H2AFX KRT7 PTPRC AR SMARCB1 CD34
2 hematopoietic system MP:0005397 9.8 H2AFX PTPRC AR SMARCB1 TCHP CD34
3 homeostasis/metabolism MP:0005376 9.76 H2AFX KRT7 PTPRC AR SMARCB1 TCHP
4 digestive/alimentary MP:0005381 9.72 GPX1 PTPRC AR SMARCB1 TWIST1
5 immune system MP:0005387 9.5 H2AFX PTPRC AR SMARCB1 TCHP CD34
6 neoplasm MP:0002006 9.02 H2AFX PTPRC AR SMARCB1 CD34

Drugs & Therapeutics for Vulvar Sarcoma

Search Clinical Trials , NIH Clinical Center for Vulvar Sarcoma

Genetic Tests for Vulvar Sarcoma

Anatomical Context for Vulvar Sarcoma

MalaCards organs/tissues related to Vulvar Sarcoma:

41
Myeloid

Publications for Vulvar Sarcoma

Articles related to Vulvar Sarcoma:

# Title Authors Year
1
Clear cell sarcoma of vulva. A case report. ( 27869448 )
2016
2
Myeloid Sarcoma Of Vulva: A Short Update. ( 27408359 )
2016
3
A rare association between neurofibromatosis type 1 and vulvar sarcoma. ( 24819769 )
2014
4
Epithelioid sarcoma of vulva: a case report and review of the literature. ( 15579921 )
2004
5
Vulvar sarcoma: clinical implications. ( 7821491 )
1994
6
Vulvar sarcoma: a report of four cases. ( 1526519 )
1992

Variations for Vulvar Sarcoma

Expression for Vulvar Sarcoma

Search GEO for disease gene expression data for Vulvar Sarcoma.

Pathways for Vulvar Sarcoma

Pathways related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.95 CD34 GPX1 PTPRC
2 11.33 AR EWSR1 H2AFX SMARCB1
3 10.88 CD34 PTPRC
4 10.64 AR TWIST1

GO Terms for Vulvar Sarcoma

Cellular components related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.13 AR H2AFX SMARCB1
2 XY body GO:0001741 8.62 H2AFX SMARCB1

Biological processes related to Vulvar Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of tumor necrosis factor production GO:0032720 8.62 CD34 TWIST1

Sources for Vulvar Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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