Vulvar Seborrheic Keratosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Vulvar Seborrheic Keratosis

MalaCards integrated aliases for Vulvar Seborrheic Keratosis:

Name: Vulvar Seborrheic Keratosis ¹² ¹⁵ ¹⁷ ⁷⁴

Seborrheic Keratosis of Vulva ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6944

NCIt ⁵¹ C6375

EFO ¹⁷ EFO_1000779

UMLS ⁷⁴ C1336981

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Summaries for Vulvar Seborrheic Keratosis

MalaCards based summary : Vulvar Seborrheic Keratosis, also known as seborrheic keratosis of vulva, is related to keratosis and bartholin's gland disease. An important gene associated with Vulvar Seborrheic Keratosis is MTOR (Mechanistic Target Of Rapamycin Kinase), and among its related pathways/superpathways are Regulation of TP53 Activity and Endometrial cancer. Affiliated tissues include skin, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Vulvar Seborrheic Keratosis

Diseases related to Vulvar Seborrheic Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)

#	Related Disease	Score	Top Affiliating Genes
1	keratosis	10.5
2	bartholin's gland disease	9.8	CDKN2A MTOR
3	plasmablastic lymphoma	9.8	CDKN2A MTOR
4	ewing's family of tumors	9.8	CDKN2A MTOR
5	cytomegalovirus infection	9.8	CDKN2A MTOR
6	mantle cell lymphoma	9.8	CDKN2A MTOR
7	cholangiocarcinoma	9.8	CDKN2A MTOR
8	glioblastoma multiforme	9.8	CDKN2A MTOR
9	glioblastoma	9.7	CDKN2A MTOR
10	large intestine cancer	9.7	CDKN2A MTOR
11	cervical cancer	9.7	CDKN2A MTOR
12	endometrial cancer	9.6	CDKN2A MTOR
13	pancreatic cancer	9.5	CDKN2A MTOR

Graphical network of the top 20 diseases related to Vulvar Seborrheic Keratosis:

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Symptoms & Phenotypes for Vulvar Seborrheic Keratosis

GenomeRNAi Phenotypes related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	9.62	MTOR
2	Decreased viability	GR00221-A-1	9.62	CDKN2A MTOR
3	Decreased viability	GR00221-A-3	9.62	CDKN2A
4	Decreased viability	GR00221-A-4	9.62	CDKN2A MTOR
5	Decreased viability	GR00342-S-1	9.62	MTOR
6	Decreased viability	GR00342-S-2	9.62	MTOR
7	Decreased viability	GR00402-S-2	9.62	CDKN2A MTOR

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Drugs & Therapeutics for Vulvar Seborrheic Keratosis

Search Clinical Trials , NIH Clinical Center for Vulvar Seborrheic Keratosis

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Genetic Tests for Vulvar Seborrheic Keratosis

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Anatomical Context for Vulvar Seborrheic Keratosis

MalaCards organs/tissues related to Vulvar Seborrheic Keratosis:

⁴²

Skin

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Publications for Vulvar Seborrheic Keratosis

Articles related to Vulvar Seborrheic Keratosis:

#	Title	Authors	Year
1	Response to &quot;Vulvar seborrheic keratosis and human papillomavirus&quot;. ( 25535983 )	Reutter J....Geisinger K.	2015
2	Vulvar seborrheic keratosis and human papillomavirus. ( 25535982 )	Joob B....Wiwanitkit V.	2015
3	Vulvar seborrheic keratosis: is there a relationship to human papillomavirus? ( 24556611 )	Reutter J.C....Laudadio J.	2014
4	Vulvar seborrheic keratosis. ( 18053380 )	Shier R.M....Rasty G.	2007
5	Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis. ( 12827609 )	Bai H....Crum C.P.	2003

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Genes for Vulvar Seborrheic Keratosis

Genes related to Vulvar Seborrheic Keratosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	13.4	DISEASES inferred ¹⁵
2	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	13.2	DISEASES inferred ¹⁵

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Variations for Vulvar Seborrheic Keratosis

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Expression for Vulvar Seborrheic Keratosis

Search GEO for disease gene expression data for Vulvar Seborrheic Keratosis.

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Pathways for Vulvar Seborrheic Keratosis

Pathways related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Regulation of TP53 Activity ⁶⁷ Show member pathways Regulation of TP53 Activity through Association with Co-factors ⁶⁷ Regulation of TP53 Activity through Methylation ⁶⁷ Regulation of TP53 Activity through Phosphorylation ⁶⁷ Transcriptional Regulation by TP53 ⁶⁷	12.3	CDKN2A MTOR
2	Endometrial cancer ³⁸ Show member pathways Acute myeloid leukemia ³⁸ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁷ Chronic myeloid leukemia ³⁸ Colorectal cancer ³⁸ Pancreatic cancer ³⁸ Prostate cancer ³⁸ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁸	12.2	CDKN2A MTOR
3	Pathways in cancer ³⁸	12.16	CDKN2A MTOR
4	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	12.03	CDKN2A MTOR
5	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12	CDKN2A MTOR
6	MicroRNAs in cancer ³⁸	11.8	CDKN2A MTOR
7	Cellular senescence (KEGG) ³⁸	11.46	CDKN2A MTOR
8	Glioblastoma Multiforme ⁶⁵	11.2	CDKN2A MTOR
9	Senescence and Autophagy in Cancer ¹	10.98	CDKN2A MTOR
10	Regulation of TP53 Expression and Degradation ⁶⁷ Show member pathways Regulation of TP53 Degradation ⁶⁷ Regulation of TP53 Expression ⁶⁷	10.49	CDKN2A MTOR

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GO Terms for Vulvar Seborrheic Keratosis

Biological processes related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	8.96	CDKN2A MTOR
2	cell cycle arrest	GO:0007050	8.62	CDKN2A MTOR

Molecular functions related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:0019901	8.62	CDKN2A MTOR

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Sources for Vulvar Seborrheic Keratosis

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