MCID: VLV039
MIFTS: 25

Vulvar Seborrheic Keratosis

Categories: Cancer diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Vulvar Seborrheic Keratosis

MalaCards integrated aliases for Vulvar Seborrheic Keratosis:

Name: Vulvar Seborrheic Keratosis 12 15 17 71
Seborrheic Keratosis of Vulva 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6944
NCIt 49 C6375
UMLS 71 C1336981

Summaries for Vulvar Seborrheic Keratosis

MalaCards based summary : Vulvar Seborrheic Keratosis, also known as seborrheic keratosis of vulva, is related to keratosis, seborrheic and keratosis. An important gene associated with Vulvar Seborrheic Keratosis is TOR1A (Torsin Family 1 Member A), and among its related pathways/superpathways are Regulation of TP53 Activity and Endometrial cancer. Affiliated tissues include skin, and related phenotype is muscle.

Related Diseases for Vulvar Seborrheic Keratosis

Diseases related to Vulvar Seborrheic Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 keratosis, seborrheic 30.5 MTOR CDKN2A
2 keratosis 10.6
3 inverted follicular keratosis 10.6
4 familial episodic pain syndrome 10.2
5 papilloma 10.2
6 microscopic colitis 10.1 TOR1A PTEN
7 subependymal glioma 10.0 PTEN MTOR
8 palmoplantar keratoderma, bothnian type 10.0 PTEN MTOR
9 birt-hogg-dube syndrome 10.0 PTEN MTOR
10 proteus syndrome 10.0 PTEN MTOR
11 central nervous system benign neoplasm 10.0 PTEN MTOR
12 thymus gland disease 10.0 PTEN MTOR
13 thymus cancer 10.0 PTEN MTOR
14 tuberous sclerosis 1 10.0 PTEN MTOR
15 tuberous sclerosis 2 10.0 PTEN MTOR
16 ocular hypertension 10.0 PTEN MTOR
17 ovarian clear cell carcinoma 10.0 PTEN MTOR
18 endometrial hyperplasia 9.9 PTEN MTOR
19 neurofibromatosis, type ii 9.9 PTEN MTOR
20 rare cancer of corpus uteri 9.9 PTEN MTOR
21 cowden syndrome 1 9.9 PTEN MTOR
22 cowden syndrome 9.9 PTEN MTOR
23 cecal benign neoplasm 9.9 PTEN CDKN2A
24 cecum adenoma 9.9 PTEN CDKN2A
25 non-alcoholic steatohepatitis 9.9 PTEN MTOR
26 primary cutaneous b-cell lymphoma 9.8 PTEN CDKN2A
27 adult astrocytic tumour 9.8 PTEN CDKN2A
28 peritoneum cancer 9.8 PTEN CDKN2A
29 acral lentiginous melanoma 9.8 PTEN CDKN2A
30 gliomatosis cerebri 9.8 PTEN CDKN2A
31 fibrillary astrocytoma 9.8 PTEN CDKN2A
32 respiratory system benign neoplasm 9.8 PTEN CDKN2A
33 penile disease 9.8 PTEN CDKN2A
34 verrucous carcinoma 9.8 PTEN CDKN2A
35 cystic teratoma 9.8 PTEN CDKN2A
36 teratoma 9.8 PTEN CDKN2A
37 ovarian cystadenocarcinoma 9.8 PTEN CDKN2A
38 reproductive organ benign neoplasm 9.8 PTEN CDKN2A
39 uterine corpus cancer 9.8 PTEN CDKN2A
40 giant cell glioblastoma 9.8 PTEN CDKN2A
41 bilateral breast cancer 9.8 PTEN CDKN2A
42 brain stem glioma 9.8 PTEN CDKN2A
43 penile cancer 9.8 PTEN CDKN2A
44 serous cystadenocarcinoma 9.8 PTEN CDKN2A
45 pre-malignant neoplasm 9.8 PTEN CDKN2A
46 sporadic breast cancer 9.8 PTEN CDKN2A
47 skin squamous cell carcinoma 9.8 PTEN CDKN2A
48 endometrial adenocarcinoma 9.8 PTEN CDKN2A
49 in situ carcinoma 9.8 PTEN CDKN2A
50 small cell carcinoma 9.8 PTEN CDKN2A

Graphical network of the top 20 diseases related to Vulvar Seborrheic Keratosis:



Diseases related to Vulvar Seborrheic Keratosis

Symptoms & Phenotypes for Vulvar Seborrheic Keratosis

MGI Mouse Phenotypes related to Vulvar Seborrheic Keratosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.92 CDKN2A MTOR PTEN TOR1A

Drugs & Therapeutics for Vulvar Seborrheic Keratosis

Search Clinical Trials , NIH Clinical Center for Vulvar Seborrheic Keratosis

Genetic Tests for Vulvar Seborrheic Keratosis

Anatomical Context for Vulvar Seborrheic Keratosis

MalaCards organs/tissues related to Vulvar Seborrheic Keratosis:

40
Skin

Publications for Vulvar Seborrheic Keratosis

Articles related to Vulvar Seborrheic Keratosis:

# Title Authors PMID Year
1
Vulvar seborrheic keratosis and human papillomavirus. 61
25535982 2015
2
Response to "Vulvar seborrheic keratosis and human papillomavirus". 61
25535983 2015
3
Vulvar seborrheic keratosis: is there a relationship to human papillomavirus? 61
24556611 2014
4
Vulvar seborrheic keratosis. 61
18053380 2007
5
Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis. 61
12827609 2003

Variations for Vulvar Seborrheic Keratosis

Expression for Vulvar Seborrheic Keratosis

Search GEO for disease gene expression data for Vulvar Seborrheic Keratosis.

Pathways for Vulvar Seborrheic Keratosis

Pathways related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 PTEN MTOR CDKN2A
2
Show member pathways
12.4 PTEN MTOR CDKN2A
3 12.36 PTEN MTOR CDKN2A
4
Show member pathways
12.28 PTEN MTOR CDKN2A
5
Show member pathways
12.18 PTEN MTOR CDKN2A
6 11.92 PTEN MTOR CDKN2A
7 11.7 PTEN MTOR
8 11.62 PTEN CDKN2A
9
Show member pathways
11.59 PTEN MTOR
10 11.52 PTEN MTOR CDKN2A
11 11.47 PTEN MTOR
12
Show member pathways
11.37 MTOR CDKN2A
13 11.34 PTEN MTOR
14 11.18 PTEN MTOR CDKN2A
15 10.86 PTEN MTOR
16 10.82 PTEN MTOR CDKN2A
17 10.8 PTEN MTOR

GO Terms for Vulvar Seborrheic Keratosis

Cellular components related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 PML body GO:0016605 8.96 PTEN MTOR
2 postsynaptic cytosol GO:0099524 8.62 PTEN MTOR

Biological processes related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.58 PTEN MTOR CDKN2A
2 neuron projection development GO:0031175 9.54 TOR1A PTEN
3 cell cycle arrest GO:0007050 9.52 MTOR CDKN2A
4 cellular response to hypoxia GO:0071456 9.51 PTEN MTOR
5 regulation of protein stability GO:0031647 9.49 PTEN CDKN2A
6 negative regulation of protein phosphorylation GO:0001933 9.48 PTEN MTOR
7 response to nutrient GO:0007584 9.46 PTEN MTOR
8 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.43 PTEN CDKN2A
9 social behavior GO:0035176 9.37 PTEN MTOR
10 response to activity GO:0014823 9.32 PTEN MTOR
11 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.26 PTEN CDKN2A
12 cardiac muscle tissue development GO:0048738 9.16 PTEN MTOR
13 regulation of protein kinase B signaling GO:0051896 8.96 PTEN MTOR
14 negative regulation of cell size GO:0045792 8.62 PTEN MTOR

Molecular functions related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 8.8 PTEN MTOR CDKN2A

Sources for Vulvar Seborrheic Keratosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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