Vulvar Seborrheic Keratosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Vulvar Seborrheic Keratosis

MalaCards integrated aliases for Vulvar Seborrheic Keratosis:

Name: Vulvar Seborrheic Keratosis ¹² ¹⁵ ⁷³

Seborrheic Keratosis of Vulva ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6944

NCIt ⁵⁰ C6375

UMLS ⁷³ C1336981

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Summaries for Vulvar Seborrheic Keratosis

MalaCards based summary : Vulvar Seborrheic Keratosis, also known as seborrheic keratosis of vulva, is related to keratosis and bartholin's gland benign neoplasm. An important gene associated with Vulvar Seborrheic Keratosis is MTOR (Mechanistic Target Of Rapamycin Kinase), and among its related pathways/superpathways are Regulation of TP53 Activity and Endometrial cancer. Affiliated tissues include skin, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Vulvar Seborrheic Keratosis

Diseases related to Vulvar Seborrheic Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	keratosis	10.4
2	bartholin's gland benign neoplasm	9.6	CDKN2A MTOR
3	plasmablastic lymphoma	9.6	CDKN2A MTOR
4	ewing's family of tumors	9.6	CDKN2A MTOR
5	mantle cell lymphoma	9.5	CDKN2A MTOR
6	myeloma, multiple	9.5	CDKN2A MTOR
7	glioblastoma multiforme	9.4	CDKN2A MTOR
8	cervical cancer	9.3	CDKN2A MTOR
9	glioblastoma	9.2	CDKN2A MTOR
10	endometrial cancer	9.0	CDKN2A MTOR

Graphical network of the top 20 diseases related to Vulvar Seborrheic Keratosis:

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Symptoms & Phenotypes for Vulvar Seborrheic Keratosis

GenomeRNAi Phenotypes related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	9.62	MTOR
2	Decreased viability	GR00221-A-1	9.62	CDKN2A MTOR
3	Decreased viability	GR00221-A-3	9.62	CDKN2A
4	Decreased viability	GR00221-A-4	9.62	CDKN2A MTOR
5	Decreased viability	GR00342-S-1	9.62	MTOR
6	Decreased viability	GR00342-S-2	9.62	MTOR
7	Decreased viability	GR00402-S-2	9.62	CDKN2A MTOR

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Drugs & Therapeutics for Vulvar Seborrheic Keratosis

Search Clinical Trials , NIH Clinical Center for Vulvar Seborrheic Keratosis

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Genetic Tests for Vulvar Seborrheic Keratosis

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Anatomical Context for Vulvar Seborrheic Keratosis

MalaCards organs/tissues related to Vulvar Seborrheic Keratosis:

⁴¹

Skin

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Publications for Vulvar Seborrheic Keratosis

Articles related to Vulvar Seborrheic Keratosis:

#	Title	Authors	Year
1	Response to &quot;Vulvar seborrheic keratosis and human papillomavirus&quot;. ( 25535983 )	Reutter J....Geisinger K.	2015
2	Vulvar seborrheic keratosis and human papillomavirus. ( 25535982 )	Joob B....Wiwanitkit V.	2015
3	Vulvar seborrheic keratosis: is there a relationship to human papillomavirus? ( 24556611 )	Reutter J.C....Laudadio J.	2014
4	Vulvar seborrheic keratosis. ( 18053380 )	Shier R.M....Rasty G.	2007
5	Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis. ( 12827609 )	Bai H....Crum C.P.	2003

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Genes for Vulvar Seborrheic Keratosis

Genes related to Vulvar Seborrheic Keratosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	13.53	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	13.34	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Vulvar Seborrheic Keratosis

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Expression for Vulvar Seborrheic Keratosis

Search GEO for disease gene expression data for Vulvar Seborrheic Keratosis.

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Pathways for Vulvar Seborrheic Keratosis

Pathways related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Regulation of TP53 Activity ⁶⁶ Show member pathways Regulation of TP53 Activity through Association with Co-factors ⁶⁶ Regulation of TP53 Activity through Methylation ⁶⁶ Regulation of TP53 Activity through Phosphorylation ⁶⁶ Transcriptional Regulation by TP53 ⁶⁶	12.3	CDKN2A MTOR
2	Endometrial cancer ³⁷ Show member pathways Acute myeloid leukemia ³⁷ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁶ Chronic myeloid leukemia ³⁷ Colorectal cancer ³⁷ Pancreatic cancer ³⁷ Prostate cancer ³⁷ Signal transduction PTEN pathway ²² Thyroid cancer ³⁷	12.2	CDKN2A MTOR
3	Pathways in cancer ³⁷	12.15	CDKN2A MTOR
4	Glioma ³⁷ Show member pathways EGFR tyrosine kinase inhibitor resistance ³⁷ Endocrine resistance ³⁷ Melanoma ³⁷ Non-small cell lung cancer ³⁷ Signaling Pathways in Glioblastoma ¹	12.07	CDKN2A MTOR
5	Gastric cancer ³⁷ Show member pathways Breast cancer ³⁷ Hepatocellular carcinoma ³⁷	12.03	CDKN2A MTOR
6	MicroRNAs in cancer ³⁷	11.8	CDKN2A MTOR
7	Cellular senescence (KEGG) ³⁷	11.46	CDKN2A MTOR
8	Glioblastoma Multiforme ⁶⁴	11.2	CDKN2A MTOR
9	Senescence and Autophagy in Cancer ¹	10.98	CDKN2A MTOR
10	Regulation of TP53 Expression and Degradation ⁶⁶ Show member pathways Regulation of TP53 Degradation ⁶⁶ Regulation of TP53 Expression ⁶⁶	10.49	CDKN2A MTOR

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GO Terms for Vulvar Seborrheic Keratosis

Biological processes related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	phosphorylation	GO:0016310	9.16	CDKN2A MTOR
2	positive regulation of gene expression	GO:0010628	8.96	CDKN2A MTOR
3	cell cycle arrest	GO:0007050	8.62	CDKN2A MTOR

Molecular functions related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	kinase activity	GO:0016301	8.96	CDKN2A MTOR
2	protein kinase binding	GO:0019901	8.62	CDKN2A MTOR

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Sources for Vulvar Seborrheic Keratosis

¹ BioSystems

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⁷⁶ Wikipedia