Vulvar Seborrheic Keratosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Vulvar Seborrheic Keratosis

MalaCards integrated aliases for Vulvar Seborrheic Keratosis:

IMPROVED

Name: Vulvar Seborrheic Keratosis ¹¹ ¹⁴ ¹⁶ ⁷¹

Seborrheic Keratosis of Vulva ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:6944

NCIt ⁴⁹ C6375

EFO ¹⁶ EFO_1000779

UMLS ⁷¹ C1336981

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Summaries for Vulvar Seborrheic Keratosis

MalaCards based summary: Vulvar Seborrheic Keratosis, also known as seborrheic keratosis of vulva, is related to papilloma and keratosis, seborrheic. An important gene associated with Vulvar Seborrheic Keratosis is TOR1A (Torsin Family 1 Member A), and among its related pathways/superpathways are T-cell activation SARS-CoV-2 and Fragile X syndrome. Affiliated tissues include skin and cervix, and related phenotypes are Increased apoptosis and muscle

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Related Diseases for Vulvar Seborrheic Keratosis

Diseases related to Vulvar Seborrheic Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)

#	Related Disease	Score	Top Affiliating Genes
1	papilloma	30.0	PTEN CDKN2A
2	keratosis, seborrheic	10.5
3	keratosis	10.5
4	familial episodic pain syndrome	10.1
5	anogenital venereal wart	10.1
6	idh-wildtype glioblastoma	9.9	PTEN CDKN2A
7	papillary adenofibroma	9.9	PTEN CDKN2A
8	vaginal cancer	9.9	PTEN CDKN2A
9	mixed glioma	9.9	PTEN CDKN2A
10	nodular malignant melanoma	9.9	PTEN CDKN2A
11	mucosal melanoma	9.9	PTEN CDKN2A
12	vulvar disease	9.9	PTEN CDKN2A
13	diffuse astrocytoma	9.9	PTEN CDKN2A
14	lung adenoma	9.9	PTEN CDKN2A
15	familial retinoblastoma	9.9	PTEN CDKN2A
16	respiratory system benign neoplasm	9.9	PTEN CDKN2A
17	mixed cell type cancer	9.9	PTEN CDKN2A
18	bilateral breast cancer	9.9	PTEN CDKN2A
19	endocervical carcinoma	9.9	PTEN CDKN2A
20	skin squamous cell carcinoma	9.9	PTEN CDKN2A
21	muir-torre syndrome	9.9	PTEN CDKN2A
22	uterine benign neoplasm	9.9	PTEN CDKN2A
23	melanoma in congenital melanocytic nevus	9.9	PTEN CDKN2A
24	reproductive organ benign neoplasm	9.9	PTEN CDKN2A
25	endometrial adenocarcinoma	9.9	PTEN CDKN2A
26	endocervical adenocarcinoma	9.9	PTEN CDKN2A
27	anaplastic oligodendroglioma	9.9	PTEN CDKN2A
28	oligodendroglioma	9.9	PTEN CDKN2A
29	vulva cancer	9.9	PTEN CDKN2A
30	breast carcinoma in situ	9.9	PTEN CDKN2A
31	ovarian cystadenocarcinoma	9.9	PTEN CDKN2A
32	serous cystadenocarcinoma	9.9	PTEN CDKN2A
33	small intestine cancer	9.9	PTEN CDKN2A
34	ductal carcinoma in situ	9.9	PTEN CDKN2A
35	oropharynx cancer	9.9	PTEN CDKN2A
36	in situ carcinoma	9.9	PTEN CDKN2A
37	pre-malignant neoplasm	9.9	PTEN CDKN2A
38	uterine corpus cancer	9.9	PTEN CDKN2A
39	muscle cancer	9.9	PTEN CDKN2A
40	ovary adenocarcinoma	9.9	PTEN CDKN2A
41	giant cell glioblastoma	9.9	PTEN CDKN2A
42	brain glioma	9.9	PTEN CDKN2A
43	neurofibroma	9.9	PTEN CDKN2A
44	ovarian serous cystadenocarcinoma	9.9	PTEN CDKN2A
45	carcinosarcoma	9.9	PTEN CDKN2A
46	human papillomavirus infectious disease	9.9	PTEN CDKN2A
47	intestinal benign neoplasm	9.9	PTEN CDKN2A
48	low grade glioma	9.9	PTEN CDKN2A
49	endometrial hyperplasia	9.9	PTEN CDKN2A
50	central nervous system benign neoplasm	9.9	PTEN CDKN2A

Graphical network of the top 20 diseases related to Vulvar Seborrheic Keratosis:

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Symptoms & Phenotypes for Vulvar Seborrheic Keratosis

GenomeRNAi Phenotypes related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased apoptosis	GR00093-A-0	8.62	CDKN2A PTEN

MGI Mouse Phenotypes related to Vulvar Seborrheic Keratosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	8.8	CDKN2A PTEN TOR1A

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Drugs & Therapeutics for Vulvar Seborrheic Keratosis

Search Clinical Trials, NIH Clinical Center for Vulvar Seborrheic Keratosis

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Genetic Tests for Vulvar Seborrheic Keratosis

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Anatomical Context for Vulvar Seborrheic Keratosis

Organs/tissues related to Vulvar Seborrheic Keratosis:

MalaCards : Skin, Cervix

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Publications for Vulvar Seborrheic Keratosis

Articles related to Vulvar Seborrheic Keratosis:

#	Title	Authors	PMID	Year
1	Seborrheic Keratosis-Like Lesion of the Cervix: First Report of the Cytological Features of a Low-Risk HPV 42-Associated Lesion. ⁶²	Pujari R...McCluggage WG	34293740	2021
2	Response to "Vulvar seborrheic keratosis and human papillomavirus". ⁶²	Reutter J...Geisinger K	25535983	2015
3	Vulvar seborrheic keratosis and human papillomavirus. ⁶²	Joob B...Wiwanitkit V	25535982	2015
4	Vulvar seborrheic keratosis: is there a relationship to human papillomavirus? ⁶²	Reutter JC...Laudadio J	24556611	2014
5	Vulvar seborrheic keratosis. ⁶²	Shier RM...Rasty G	18053380	2007
6	Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis. ⁶²	Bai H...Crum CP	12827609	2003

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Genes for Vulvar Seborrheic Keratosis

Genes related to Vulvar Seborrheic Keratosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TOR1A	Torsin Family 1 Member A	Protein Coding	4.6	DISEASES inferred ¹⁴
2	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	3.45	DISEASES inferred ¹⁴
3	PTEN	Phosphatase And Tensin Homolog	Protein Coding	3.25	DISEASES inferred ¹⁴

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Variations for Vulvar Seborrheic Keratosis

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Expression for Vulvar Seborrheic Keratosis

Search GEO for disease gene expression data for Vulvar Seborrheic Keratosis.

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Pathways for Vulvar Seborrheic Keratosis

Pathways related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	11.5	PTEN CDKN2A
2	Fragile X syndrome ⁷⁴ Show member pathways Pilocytic astrocytoma ⁷⁴	11.35	PTEN CDKN2A
3	Senescence and autophagy in cancer ⁷⁴	11.18	PTEN CDKN2A
4	Head and neck squamous cell carcinoma ⁷⁴	10.82	PTEN CDKN2A
5	AP-1 transcription factor network ⁶¹	10.46	PTEN CDKN2A

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GO Terms for Vulvar Seborrheic Keratosis

Biological processes related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of protein stability	GO:0031647	9.33	PTEN CDKN2A
2	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO:0045736	9.26	PTEN CDKN2A
3	negative regulation of B cell proliferation	GO:0030889	8.8	PTEN CDKN2A

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Sources for Vulvar Seborrheic Keratosis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

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⁸ Cosmic

⁹ dbSNP

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¹¹ Disease Ontology

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¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 24-Oct-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: VLV039 MIFTS: 23	Vulvar Seborrheic Keratosis Categories: Cancer diseases, Reproductive diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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