Vulvar Seborrheic Keratosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Vulvar Seborrheic Keratosis

MalaCards integrated aliases for Vulvar Seborrheic Keratosis:

Name: Vulvar Seborrheic Keratosis ¹² ¹⁵ ¹⁷ ⁷¹

Seborrheic Keratosis of Vulva ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6944

NCIt ⁴⁹ C6375

EFO ¹⁷ EFO_1000779

UMLS ⁷¹ C1336981

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Summaries for Vulvar Seborrheic Keratosis

MalaCards based summary : Vulvar Seborrheic Keratosis, also known as seborrheic keratosis of vulva, is related to keratosis, seborrheic and keratosis. An important gene associated with Vulvar Seborrheic Keratosis is TOR1A (Torsin Family 1 Member A), and among its related pathways/superpathways are Regulation of TP53 Activity and Endometrial cancer. Affiliated tissues include skin, and related phenotype is muscle.

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Related Diseases for Vulvar Seborrheic Keratosis

Diseases related to Vulvar Seborrheic Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)

#	Related Disease	Score	Top Affiliating Genes
1	keratosis, seborrheic	30.5	MTOR CDKN2A
2	keratosis	10.6
3	inverted follicular keratosis	10.6
4	familial episodic pain syndrome	10.2
5	papilloma	10.2
6	microscopic colitis	10.1	TOR1A PTEN
7	subependymal glioma	10.0	PTEN MTOR
8	palmoplantar keratoderma, bothnian type	10.0	PTEN MTOR
9	birt-hogg-dube syndrome	10.0	PTEN MTOR
10	proteus syndrome	10.0	PTEN MTOR
11	central nervous system benign neoplasm	10.0	PTEN MTOR
12	thymus gland disease	10.0	PTEN MTOR
13	thymus cancer	10.0	PTEN MTOR
14	tuberous sclerosis 1	10.0	PTEN MTOR
15	tuberous sclerosis 2	10.0	PTEN MTOR
16	ocular hypertension	10.0	PTEN MTOR
17	ovarian clear cell carcinoma	10.0	PTEN MTOR
18	endometrial hyperplasia	9.9	PTEN MTOR
19	neurofibromatosis, type ii	9.9	PTEN MTOR
20	rare cancer of corpus uteri	9.9	PTEN MTOR
21	cowden syndrome 1	9.9	PTEN MTOR
22	cowden syndrome	9.9	PTEN MTOR
23	cecal benign neoplasm	9.9	PTEN CDKN2A
24	cecum adenoma	9.9	PTEN CDKN2A
25	non-alcoholic steatohepatitis	9.9	PTEN MTOR
26	primary cutaneous b-cell lymphoma	9.8	PTEN CDKN2A
27	adult astrocytic tumour	9.8	PTEN CDKN2A
28	peritoneum cancer	9.8	PTEN CDKN2A
29	acral lentiginous melanoma	9.8	PTEN CDKN2A
30	gliomatosis cerebri	9.8	PTEN CDKN2A
31	fibrillary astrocytoma	9.8	PTEN CDKN2A
32	respiratory system benign neoplasm	9.8	PTEN CDKN2A
33	penile disease	9.8	PTEN CDKN2A
34	verrucous carcinoma	9.8	PTEN CDKN2A
35	cystic teratoma	9.8	PTEN CDKN2A
36	teratoma	9.8	PTEN CDKN2A
37	ovarian cystadenocarcinoma	9.8	PTEN CDKN2A
38	reproductive organ benign neoplasm	9.8	PTEN CDKN2A
39	uterine corpus cancer	9.8	PTEN CDKN2A
40	giant cell glioblastoma	9.8	PTEN CDKN2A
41	bilateral breast cancer	9.8	PTEN CDKN2A
42	brain stem glioma	9.8	PTEN CDKN2A
43	penile cancer	9.8	PTEN CDKN2A
44	serous cystadenocarcinoma	9.8	PTEN CDKN2A
45	pre-malignant neoplasm	9.8	PTEN CDKN2A
46	sporadic breast cancer	9.8	PTEN CDKN2A
47	skin squamous cell carcinoma	9.8	PTEN CDKN2A
48	endometrial adenocarcinoma	9.8	PTEN CDKN2A
49	in situ carcinoma	9.8	PTEN CDKN2A
50	small cell carcinoma	9.8	PTEN CDKN2A

Graphical network of the top 20 diseases related to Vulvar Seborrheic Keratosis:

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Symptoms & Phenotypes for Vulvar Seborrheic Keratosis

MGI Mouse Phenotypes related to Vulvar Seborrheic Keratosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	muscle	MP:0005369	8.92	CDKN2A MTOR PTEN TOR1A

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Drugs & Therapeutics for Vulvar Seborrheic Keratosis

Search Clinical Trials , NIH Clinical Center for Vulvar Seborrheic Keratosis

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Genetic Tests for Vulvar Seborrheic Keratosis

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Anatomical Context for Vulvar Seborrheic Keratosis

MalaCards organs/tissues related to Vulvar Seborrheic Keratosis:

⁴⁰

Skin

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Publications for Vulvar Seborrheic Keratosis

Articles related to Vulvar Seborrheic Keratosis:

#	Title	Authors	PMID	Year
1	Vulvar seborrheic keratosis and human papillomavirus. ⁶¹	Joob B...Wiwanitkit V	25535982	2015
2	Response to "Vulvar seborrheic keratosis and human papillomavirus". ⁶¹	Reutter J...Geisinger K	25535983	2015
3	Vulvar seborrheic keratosis: is there a relationship to human papillomavirus? ⁶¹	Reutter JC...Laudadio J	24556611	2014
4	Vulvar seborrheic keratosis. ⁶¹	Shier RM...Rasty G	18053380	2007
5	Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis. ⁶¹	Bai H...Crum CP	12827609	2003

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Genes for Vulvar Seborrheic Keratosis

Genes related to Vulvar Seborrheic Keratosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TOR1A	Torsin Family 1 Member A	Protein Coding	4.89	DISEASES inferred ¹⁵
2	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	3.88	DISEASES inferred ¹⁵
3	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	3.82	DISEASES inferred ¹⁵
4	PTEN	Phosphatase And Tensin Homolog	Protein Coding	3.71	DISEASES inferred ¹⁵

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Variations for Vulvar Seborrheic Keratosis

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Expression for Vulvar Seborrheic Keratosis

Search GEO for disease gene expression data for Vulvar Seborrheic Keratosis.

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Pathways for Vulvar Seborrheic Keratosis

Pathways related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Regulation of TP53 Activity ⁶⁵ Show member pathways Regulation of TP53 Activity through Association with Co-factors ⁶⁵ Regulation of TP53 Activity through Methylation ⁶⁵ Regulation of TP53 Activity through Phosphorylation ⁶⁵ Transcriptional Regulation by TP53 ⁶⁵	12.52	PTEN MTOR CDKN2A
2	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²² Thyroid cancer ³⁶	12.4	PTEN MTOR CDKN2A
3	Pathways in cancer ³⁶	12.36	PTEN MTOR CDKN2A
4	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.28	PTEN MTOR CDKN2A
5	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.18	PTEN MTOR CDKN2A
6	MicroRNAs in cancer ³⁶	11.92	PTEN MTOR CDKN2A
7	Autophagy - animal ³⁶	11.7	PTEN MTOR
8	DNA Damage Response (only ATM dependent) ¹	11.62	PTEN CDKN2A
9	Insulin resistance ³⁶ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.59	PTEN MTOR
10	Cellular senescence (KEGG) ³⁶	11.52	PTEN MTOR CDKN2A
11	TP53 Regulates Metabolic Genes ⁶⁵	11.47	PTEN MTOR
12	Regulation of TP53 Expression and Degradation ⁶⁵ Show member pathways Regulation of TP53 Degradation ⁶⁵ Regulation of TP53 Expression ⁶⁵	11.37	MTOR CDKN2A
13	Central carbon metabolism in cancer ³⁶	11.34	PTEN MTOR
14	Glioblastoma Multiforme ⁶³	11.18	PTEN MTOR CDKN2A
15	Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling ¹	10.86	PTEN MTOR
16	Senescence and Autophagy in Cancer ¹	10.82	PTEN MTOR CDKN2A
17	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities ¹	10.8	PTEN MTOR

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GO Terms for Vulvar Seborrheic Keratosis

Cellular components related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	PML body	GO:0016605	8.96	PTEN MTOR
2	postsynaptic cytosol	GO:0099524	8.62	PTEN MTOR

Biological processes related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.58	PTEN MTOR CDKN2A
2	neuron projection development	GO:0031175	9.54	TOR1A PTEN
3	cell cycle arrest	GO:0007050	9.52	MTOR CDKN2A
4	cellular response to hypoxia	GO:0071456	9.51	PTEN MTOR
5	regulation of protein stability	GO:0031647	9.49	PTEN CDKN2A
6	negative regulation of protein phosphorylation	GO:0001933	9.48	PTEN MTOR
7	response to nutrient	GO:0007584	9.46	PTEN MTOR
8	negative regulation of G1/S transition of mitotic cell cycle	GO:2000134	9.43	PTEN CDKN2A
9	social behavior	GO:0035176	9.37	PTEN MTOR
10	response to activity	GO:0014823	9.32	PTEN MTOR
11	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO:0045736	9.26	PTEN CDKN2A
12	cardiac muscle tissue development	GO:0048738	9.16	PTEN MTOR
13	regulation of protein kinase B signaling	GO:0051896	8.96	PTEN MTOR
14	negative regulation of cell size	GO:0045792	8.62	PTEN MTOR

Molecular functions related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:0019901	8.8	PTEN MTOR CDKN2A

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