MCID: VLV039
MIFTS: 23

Vulvar Seborrheic Keratosis

Categories: Cancer diseases, Reproductive diseases, Skin diseases
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Aliases & Classifications for Vulvar Seborrheic Keratosis

MalaCards integrated aliases for Vulvar Seborrheic Keratosis:

Name: Vulvar Seborrheic Keratosis 11 14 16 71
Seborrheic Keratosis of Vulva 11

Classifications:



External Ids:

Disease Ontology 11 DOID:6944
NCIt 49 C6375
UMLS 71 C1336981

Summaries for Vulvar Seborrheic Keratosis

MalaCards based summary: Vulvar Seborrheic Keratosis, also known as seborrheic keratosis of vulva, is related to papilloma and keratosis, seborrheic. An important gene associated with Vulvar Seborrheic Keratosis is TOR1A (Torsin Family 1 Member A), and among its related pathways/superpathways are T-cell activation SARS-CoV-2 and Fragile X syndrome. Affiliated tissues include skin and cervix, and related phenotypes are Increased apoptosis and muscle

Related Diseases for Vulvar Seborrheic Keratosis

Diseases related to Vulvar Seborrheic Keratosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 papilloma 30.0 PTEN CDKN2A
2 keratosis, seborrheic 10.5
3 keratosis 10.5
4 familial episodic pain syndrome 10.1
5 anogenital venereal wart 10.1
6 idh-wildtype glioblastoma 9.9 PTEN CDKN2A
7 papillary adenofibroma 9.9 PTEN CDKN2A
8 vaginal cancer 9.9 PTEN CDKN2A
9 mixed glioma 9.9 PTEN CDKN2A
10 nodular malignant melanoma 9.9 PTEN CDKN2A
11 mucosal melanoma 9.9 PTEN CDKN2A
12 vulvar disease 9.9 PTEN CDKN2A
13 diffuse astrocytoma 9.9 PTEN CDKN2A
14 lung adenoma 9.9 PTEN CDKN2A
15 familial retinoblastoma 9.9 PTEN CDKN2A
16 respiratory system benign neoplasm 9.9 PTEN CDKN2A
17 mixed cell type cancer 9.9 PTEN CDKN2A
18 bilateral breast cancer 9.9 PTEN CDKN2A
19 endocervical carcinoma 9.9 PTEN CDKN2A
20 skin squamous cell carcinoma 9.9 PTEN CDKN2A
21 muir-torre syndrome 9.9 PTEN CDKN2A
22 uterine benign neoplasm 9.9 PTEN CDKN2A
23 melanoma in congenital melanocytic nevus 9.9 PTEN CDKN2A
24 reproductive organ benign neoplasm 9.9 PTEN CDKN2A
25 endometrial adenocarcinoma 9.9 PTEN CDKN2A
26 endocervical adenocarcinoma 9.9 PTEN CDKN2A
27 anaplastic oligodendroglioma 9.9 PTEN CDKN2A
28 oligodendroglioma 9.9 PTEN CDKN2A
29 vulva cancer 9.9 PTEN CDKN2A
30 breast carcinoma in situ 9.9 PTEN CDKN2A
31 ovarian cystadenocarcinoma 9.9 PTEN CDKN2A
32 serous cystadenocarcinoma 9.9 PTEN CDKN2A
33 small intestine cancer 9.9 PTEN CDKN2A
34 ductal carcinoma in situ 9.9 PTEN CDKN2A
35 oropharynx cancer 9.9 PTEN CDKN2A
36 in situ carcinoma 9.9 PTEN CDKN2A
37 pre-malignant neoplasm 9.9 PTEN CDKN2A
38 uterine corpus cancer 9.9 PTEN CDKN2A
39 muscle cancer 9.9 PTEN CDKN2A
40 ovary adenocarcinoma 9.9 PTEN CDKN2A
41 giant cell glioblastoma 9.9 PTEN CDKN2A
42 brain glioma 9.9 PTEN CDKN2A
43 neurofibroma 9.9 PTEN CDKN2A
44 ovarian serous cystadenocarcinoma 9.9 PTEN CDKN2A
45 carcinosarcoma 9.9 PTEN CDKN2A
46 human papillomavirus infectious disease 9.9 PTEN CDKN2A
47 intestinal benign neoplasm 9.9 PTEN CDKN2A
48 low grade glioma 9.9 PTEN CDKN2A
49 endometrial hyperplasia 9.9 PTEN CDKN2A
50 central nervous system benign neoplasm 9.9 PTEN CDKN2A

Graphical network of the top 20 diseases related to Vulvar Seborrheic Keratosis:



Diseases related to Vulvar Seborrheic Keratosis

Symptoms & Phenotypes for Vulvar Seborrheic Keratosis

GenomeRNAi Phenotypes related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased apoptosis GR00093-A-0 8.62 CDKN2A PTEN

MGI Mouse Phenotypes related to Vulvar Seborrheic Keratosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 8.8 CDKN2A PTEN TOR1A

Drugs & Therapeutics for Vulvar Seborrheic Keratosis

Search Clinical Trials, NIH Clinical Center for Vulvar Seborrheic Keratosis

Genetic Tests for Vulvar Seborrheic Keratosis

Anatomical Context for Vulvar Seborrheic Keratosis

Organs/tissues related to Vulvar Seborrheic Keratosis:

MalaCards : Skin, Cervix

Publications for Vulvar Seborrheic Keratosis

Articles related to Vulvar Seborrheic Keratosis:

# Title Authors PMID Year
1
Seborrheic Keratosis-Like Lesion of the Cervix: First Report of the Cytological Features of a Low-Risk HPV 42-Associated Lesion. 62
34293740 2021
2
Response to "Vulvar seborrheic keratosis and human papillomavirus". 62
25535983 2015
3
Vulvar seborrheic keratosis and human papillomavirus. 62
25535982 2015
4
Vulvar seborrheic keratosis: is there a relationship to human papillomavirus? 62
24556611 2014
5
Vulvar seborrheic keratosis. 62
18053380 2007
6
Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis. 62
12827609 2003

Variations for Vulvar Seborrheic Keratosis

Expression for Vulvar Seborrheic Keratosis

Search GEO for disease gene expression data for Vulvar Seborrheic Keratosis.

Pathways for Vulvar Seborrheic Keratosis

Pathways related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.5 PTEN CDKN2A
2
Show member pathways
11.35 PTEN CDKN2A
3 11.18 PTEN CDKN2A
4 10.82 PTEN CDKN2A
5 10.46 PTEN CDKN2A

GO Terms for Vulvar Seborrheic Keratosis

Biological processes related to Vulvar Seborrheic Keratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of protein stability GO:0031647 9.33 PTEN CDKN2A
2 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 9.26 PTEN CDKN2A
3 negative regulation of B cell proliferation GO:0030889 8.8 PTEN CDKN2A

Sources for Vulvar Seborrheic Keratosis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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