MCID: VLV019
MIFTS: 24

Vulvar Syringoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Vulvar Syringoma

MalaCards integrated aliases for Vulvar Syringoma:

Name: Vulvar Syringoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2064
NCIt 50 C40311
UMLS 70 C1520099

Summaries for Vulvar Syringoma

Disease Ontology : 12 A vulvar benign neoplasm that is characterized by the comma tadpole shaped tail of dilated, cystic eccrine ducts, derives from the eccrine sweat gland and presents as multiple, small, soft, skin-colored-to-yellowish papules, and has symptom vulvar discomfort and has symptom itching.

MalaCards based summary : Vulvar Syringoma is related to syringoma and bartholin's gland disease, and has symptoms including itching and vulvar discomfort. An important gene associated with Vulvar Syringoma is ESR1 (Estrogen Receptor 1), and among its related pathways/superpathways are Cell cycle Role of SCF complex in cell cycle regulation and Signaling by ERBB4. Affiliated tissues include skin, and related phenotype is Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435).

Related Diseases for Vulvar Syringoma

Diseases related to Vulvar Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 syringoma 10.6
2 bartholin's gland disease 9.9 PIP PGR
3 glycogen-rich clear cell breast carcinoma 9.9 PIP PGR
4 dry eye syndrome 9.9 PIP ESR1
5 breast mucinous carcinoma 9.9 PIP PGR
6 gastric diffuse adenocarcinoma 9.9 PIP PGR
7 eccrine papillary adenocarcinoma 9.9 PIP PGR
8 papillary adenocarcinoma 9.9 PIP PGR
9 linitis plastica 9.9 PIP PGR
10 cutaneous adenocystic carcinoma 9.9 PIP PGR
11 peritoneal serous adenocarcinoma 9.9 PIP PGR
12 malignant spiradenoma 9.9 PIP PGR
13 bartholin's gland adenocarcinoma 9.9 PIP PGR
14 sweat gland benign neoplasm 9.9 PIP PGR
15 glassy cell carcinoma of the cervix 9.9 PGR ESR1
16 breast intraductal papillomatosis 9.9 PGR ESR1
17 intraductal papilloma 9.9 PGR ESR1
18 nipple carcinoma 9.9 PGR ESR1
19 bartholin's gland adenoma 9.9 PGR ESR1
20 bartholin's gland adenoid cystic carcinoma 9.9 PGR ESR1
21 uterine corpus adenosarcoma 9.9 PGR ESR1
22 adenosarcoma 9.9 PGR ESR1
23 bartholin's gland benign neoplasm 9.9 PGR ESR1
24 chronic tympanitis 9.9 PGR ESR1
25 vestibular gland benign neoplasm 9.9 PGR ESR1
26 granulomatous endometritis 9.9 PGR ESR1
27 endometritis 9.9 PGR ESR1
28 lung leiomyoma 9.9 PGR ESR1
29 leiomyoma 9.9 PGR ESR1
30 myoma 9.9 PGR ESR1
31 adult type testicular granulosa cell tumor 9.9 PGR ESR1
32 breast scirrhous carcinoma 9.9 PGR ESR1
33 cervical clear cell adenocarcinoma 9.9 PGR ESR1
34 ovarian seromucinous carcinoma 9.9 PGR ESR1
35 breast papillary carcinoma 9.9 PGR ESR1
36 papillary carcinoma 9.9 PGR ESR1
37 liver leiomyoma 9.9 PGR ESR1
38 intravenous leiomyomatosis 9.9 PGR ESR1
39 leiomyomatosis 9.9 PGR ESR1
40 comedo carcinoma 9.9 PGR ESR1
41 breast adenoid cystic carcinoma 9.9 PGR ESR1
42 breast metaplastic carcinoma 9.9 PGR ESR1
43 intracranial meningioma 9.9 PGR ESR1
44 vulvar leiomyoma 9.9 PGR ESR1
45 bizarre leiomyoma 9.9 PGR ESR1
46 breast adenoma 9.9 PGR ESR1
47 breast malignant phyllodes tumor 9.8 PGR ESR1
48 prostate stromal sarcoma 9.8 PGR ESR1
49 progesterone-receptor negative breast cancer 9.8 PGR ESR1
50 intracystic papillary adenoma 9.8 PGR ESR1

Graphical network of the top 20 diseases related to Vulvar Syringoma:



Diseases related to Vulvar Syringoma

Symptoms & Phenotypes for Vulvar Syringoma

Symptoms:

12
  • itching
  • vulvar discomfort

GenomeRNAi Phenotypes related to Vulvar Syringoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.62 ESR1 PIP

Drugs & Therapeutics for Vulvar Syringoma

Search Clinical Trials , NIH Clinical Center for Vulvar Syringoma

Genetic Tests for Vulvar Syringoma

Anatomical Context for Vulvar Syringoma

MalaCards organs/tissues related to Vulvar Syringoma:

40
Skin

Publications for Vulvar Syringoma

Articles related to Vulvar Syringoma:

(show all 21)
# Title Authors PMID Year
1
[Skin-coloured vulvar papules]. 61
33332048 2020
2
Vulvar syringoma. 61
32603397 2020
3
Visual Dermatology: Eruptive Vulvar Syringoma. 61
32208031 2020
4
Post Treatment Application of Jaungo after a Combined Therapy of Carbon Dioxide Laser and Trichloroacetic Acid in a Case of Vulvar Syringoma. 61
31673452 2019
5
[Vulvar syringoma]. 61
27400812 2016
6
Vulvar Syringoma in a Postmenopausal Woman: A Case Report. 61
26592076 2015
7
Syringoma of vulva: an unusual presentation. Clinical, morphological and immunohistochemical aspects. 61
25920186 2015
8
Vulvar syringoma: a rare case report. 61
25302203 2014
9
Multiple giant vulvar syringoma: an extraordinary report. 61
24340473 2013
10
Vulvar nonclear cell syringoma associated with pruritus and diabetes mellitus. 61
24069540 2013
11
[Vulvar syringoma: a rare cause of vulvar pruritus]. 61
18682179 2008
12
[Vulvar syringoma: a report of two cases]. 61
16972525 2006
13
Localized vulvar syringoma causing vulval pruritus and venerophobia. 61
15527439 2004
14
Vulvar syringoma: a clinicopathologic and immunohistologic study of 18 patients and results of treatment. 61
12734503 2003
15
Vulvar syringoma aggravated by pregnancy. 61
14530816 2003
16
Vulvar syringoma, report of a case and review of the literature. 61
12784970 2002
17
Vulvar syringoma showing progesterone receptor positivity. 61
10688518 2000
18
Vulvar syringoma causing pruritus and carcinophobia: treatment by argon laser. 61
11360416 1999
19
Vulvar syringoma exacerbated during pregnancy. 61
8801140 1996
20
Vulvar syringoma associated with epidermal cyst. 61
2737815 1989
21
Syringoma of the vulva: incidence, diagnosis, and cause of pruritus. 61
7366908 1980

Variations for Vulvar Syringoma

Expression for Vulvar Syringoma

Search GEO for disease gene expression data for Vulvar Syringoma.

Pathways for Vulvar Syringoma

Pathways related to Vulvar Syringoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.4 PGR ESR1
2
Show member pathways
10.99 PGR ESR1
3
Show member pathways
10.58 PGR ESR1

GO Terms for Vulvar Syringoma

Biological processes related to Vulvar Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription initiation from RNA polymerase II promoter GO:0006367 9.16 PGR ESR1
2 steroid hormone mediated signaling pathway GO:0043401 8.96 PGR ESR1
3 intracellular steroid hormone receptor signaling pathway GO:0030518 8.62 PGR ESR1

Molecular functions related to Vulvar Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATPase binding GO:0051117 9.26 PGR ESR1
2 nuclear receptor activity GO:0004879 9.16 PGR ESR1
3 steroid binding GO:0005496 8.96 PGR ESR1
4 steroid hormone receptor activity GO:0003707 8.62 PGR ESR1

Sources for Vulvar Syringoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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