VVS
MCID: VLV042
MIFTS: 45

Vulvar Vestibulitis Syndrome (VVS)

Categories: Rare diseases

Aliases & Classifications for Vulvar Vestibulitis Syndrome

MalaCards integrated aliases for Vulvar Vestibulitis Syndrome:

Name: Vulvar Vestibulitis Syndrome 54
Vulvar Dysesthesia Localized in the Vestibule 54
Vulvar Vestibulitis 74
Vvs 54

Classifications:



External Ids:

UMLS 74 C0269084

Summaries for Vulvar Vestibulitis Syndrome

MalaCards based summary : Vulvar Vestibulitis Syndrome, also known as vulvar dysesthesia localized in the vestibule, is related to vulvovaginal candidiasis and acute respiratory distress syndrome. An important gene associated with Vulvar Vestibulitis Syndrome is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and NF-kappaB Signaling. The drugs Acetylcholine and Petrolatum have been mentioned in the context of this disorder. Affiliated tissues include brain and testes, and related phenotypes are hematopoietic system and growth/size/body region

Wikipedia : 77 Vulvar vestibulitis syndrome (VVS), vestibulodynia, or simply vulvar vestibulitis, is vulvodynia... more...

Related Diseases for Vulvar Vestibulitis Syndrome

Diseases related to Vulvar Vestibulitis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
# Related Disease Score Top Affiliating Genes
1 vulvovaginal candidiasis 30.2 MBL2 NLRP3
2 acute respiratory distress syndrome 30.1 IL1B TNF
3 lung disease 29.9 IL1B MBL2 TNF
4 syncope, familial vasovagal 12.2
5 vaccinia 11.5
6 respiratory failure 10.3
7 hydrarthrosis 10.3 IL1B IL1RN
8 prosthetic joint infection 10.3 IL1B MBL2
9 root resorption 10.3 IL1B IL1RN
10 extrapulmonary tuberculosis 10.3 IL1B IL1RN
11 exudative glomerulonephritis 10.2 IL1B TNF
12 staphylococcal toxic shock syndrome 10.2 IL1B TNF
13 kashin-beck disease 10.2 IL1B TNF
14 burns 10.2 IL1B TNF
15 glossitis 10.2 IL1B TNF
16 laryngitis 10.2 IL1B TNF
17 haemophilus influenzae 10.2 IL1B TNF
18 cerebral artery occlusion 10.2 IL1B TNF
19 opisthorchiasis 10.2 IL1B TNF
20 retinitis pigmentosa 60 10.2 IL1B TNF
21 irritant dermatitis 10.2 IL1B TNF
22 acute vascular insufficiency of intestine 10.2 IL1B TNF
23 congenital cytomegalovirus 10.2 IL1B TNF
24 juvenile ankylosing spondylitis 10.2 IL1RN TNF
25 actinic prurigo 10.2 IL1B TNF
26 scleral disease 10.2 IL1RN TNF
27 crohn's colitis 10.2 IL1B TNF
28 pustulosis of palm and sole 10.2 IL1RN TNF
29 poems syndrome 10.2 IL1B TNF
30 periapical periodontitis 10.2 IL1B TNF
31 autoimmune gastritis 10.2 IL1B TNF
32 central nervous system vasculitis 10.2 IL1B TNF
33 stachybotrys chartarum 10.2 IL1B TNF
34 jejunoileitis 10.2 IL1B TNF
35 vaginitis 10.2 ESR1 IL1B
36 dental pulp disease 10.2 IL1B TNF
37 spondylosis 10.2 ESR1 IL1B
38 somatoform disorder 10.2 IL1B IL1RN
39 familial cold autoinflammatory syndrome 10.2 IL1B NLRP3
40 primary systemic mycosis 10.2 IL1B TNF
41 eales disease 10.2 IL1B TNF
42 scrub typhus 10.2 IL1B TNF
43 pulpitis 10.2 IL1B TNF
44 gastric ulcer 10.2 IL1B IL1RN
45 middle ear disease 10.2 IL1B TNF
46 lacrimal apparatus disease 10.2 IL1B TNF
47 commensal bacterial infectious disease 10.2 IL1B TNF
48 cervical adenitis 10.2 IL1B NLRP3
49 perinatal necrotizing enterocolitis 10.2 IL1B TNF
50 adult dermatomyositis 10.2 MBL2 TNF

Graphical network of the top 20 diseases related to Vulvar Vestibulitis Syndrome:



Diseases related to Vulvar Vestibulitis Syndrome

Symptoms & Phenotypes for Vulvar Vestibulitis Syndrome

MGI Mouse Phenotypes related to Vulvar Vestibulitis Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 ESR1 IL1B IL1R1 IL1RN MBL2 MC1R
2 growth/size/body region MP:0005378 9.95 ESR1 IL1B IL1R1 IL1RN MC1R NLRP3
3 homeostasis/metabolism MP:0005376 9.87 ESR1 IL1B IL1R1 IL1RN MBL2 NLRP3
4 immune system MP:0005387 9.86 ESR1 IL1B IL1R1 IL1RN MBL2 MC1R
5 integument MP:0010771 9.7 ESR1 IL1B IL1R1 IL1RN MC1R NLRP3
6 neoplasm MP:0002006 9.35 ESR1 IL1B IL1R1 MC1R TNF
7 skeleton MP:0005390 9.1 ESR1 IL1B IL1R1 IL1RN NLRP3 TNF

Drugs & Therapeutics for Vulvar Vestibulitis Syndrome

Drugs for Vulvar Vestibulitis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4,Phase 3,Phase 2 51-84-3 187
2
Petrolatum Approved, Investigational Phase 4,Phase 2 8009-03-8
3
Tamoxifen Approved Phase 4 10540-29-1 2733526
4 Botulinum Toxins, Type A Phase 4,Phase 3
5 Botulinum Toxins Phase 4,Phase 3,Phase 2
6 Acetylcholine Release Inhibitors Phase 4,Phase 3,Phase 2
7 abobotulinumtoxinA Phase 4,Phase 3
8 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
9 Cholinergic Agents Phase 4,Phase 3,Phase 2
10 Hormones Phase 4,Phase 3,Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
12 Estrogens Phase 4,Phase 2
13 Hormone Antagonists Phase 4,Phase 2
14 Tea Phase 4
15 Tomato Approved Phase 3
16
Levomilnacipran Approved, Investigational Phase 3 96847-54-0
17
Norepinephrine Approved Phase 3 51-41-2 439260
18
Milnacipran Approved, Investigational Phase 3 92623-85-3 65833
19
Nifedipine Approved Phase 3 21829-25-4 4485
20
Capsaicin Approved Phase 2, Phase 3,Phase 1 404-86-4 1548943
21
Calcium Approved, Nutraceutical Phase 3,Phase 2 7440-70-2 271
22 Analgesics Phase 3,Phase 2,Not Applicable
23 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
24 Antidepressive Agents Phase 3,Phase 2,Not Applicable
25 Psychotropic Drugs Phase 3,Phase 2,Not Applicable
26 Neurotransmitter Uptake Inhibitors Phase 3,Phase 2,Not Applicable
27 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1,Not Applicable
28 Analgesics, Non-Narcotic Phase 3
29 Vasodilator Agents Phase 3
30 Tocolytic Agents Phase 3
31 Calcium, Dietary Phase 3,Phase 2
32 calcium channel blockers Phase 3,Phase 2
33 Dermatologic Agents Phase 2, Phase 3,Phase 1,Not Applicable
34 Antipruritics Phase 2, Phase 3,Phase 1
35 Neuromuscular Agents Phase 3
36 Pharmaceutical Solutions Phase 3
37
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
38
Enoxaparin Approved Phase 2 9005-49-6 772
39
Promethazine Approved, Investigational Phase 2 60-87-7 4927
40
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
41
Histamine Approved, Investigational Phase 2 51-45-6 774
42
Lidocaine Approved, Vet_approved Phase 2,Phase 1,Not Applicable 137-58-6 3676
43
Nortriptyline Approved Phase 2 72-69-5 4543
44
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
45
Polyestradiol phosphate Approved Phase 2 28014-46-2
46
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
47 Sodium Channel Blockers Phase 2,Phase 1,Not Applicable
48 Histamine H1 Antagonists Phase 2
49 Anesthetics Phase 2,Phase 1,Not Applicable
50 Histamine Antagonists Phase 2

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4 Botulinum toxin
2 Topical Treatment for Sexual Pain, Vulvar Pain, in Postmenopausal Women Not Taking Estrogens or Similiar Hormones. Women on Tamoxifen CAN Enter the Clinical Trial Recruiting NCT03682601 Phase 4 Sinecatechins Topical
3 Dysbiosis in Localized Provoked Vulvodynia (LPV) Unknown status NCT02393911 Phase 3
4 Savella in Treatment for Provoked Vestibulodynia Completed NCT01304589 Phase 3 Milnacipran
5 Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis Completed NCT00496184 Phase 3 Nifedipine cream topical application
6 A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia Recruiting NCT02858219 Phase 3 Botulinum Toxin Type A
7 A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia Recruiting NCT02854670 Phase 2, Phase 3 Capsaicin patch
8 Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia Recruiting NCT02773641 Phase 3 Botulinum Toxin Type A;Sterile Saline Solution
9 Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis Completed NCT00004316 Phase 1, Phase 2 capsaicin
10 Enoxaparin as Treatment for Vulvodynia Completed NCT00874484 Phase 2 Clexane (enoxaparin)
11 Infiltration of the Vestibulum Vaginae With Botulin Toxin in Patients With Localized Provoked Vulvodynia Completed NCT01747161 Phase 2 Botulin toxin;physiological water
12 Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort Completed NCT00590590 Phase 2 Lidocaine/Diphenhydramine;lidocaine;placebo
13 Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments Not yet recruiting NCT03844412 Phase 2 5% lidocaine/5 mg/ml estradiol compound cream;Nortriptyline;Placebo cream;Placebo pill
14 5% Lidocaine Ointment in the Treatment of Vulvar Vestibulitis Terminated NCT00450242 Phase 2 5% topical lidocaine ointment;Placebo cream
15 Pregabalin for the Treatment of Vulvodynia Terminated NCT00853229 Phase 2 pregabalin
16 Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study Completed NCT01996384 Phase 1 Lidocaine
17 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Unknown status NCT02732145
18 Effectiveness of Cognitive Behavioural Therapy and Physical Therapy for Provoked Vestibulodynia Completed NCT02494934 Not Applicable
19 Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia Completed NCT01704456 Not Applicable
20 Integrated Mindfulness for Provoked Vestibulodynia Completed NCT01704443 Not Applicable
21 The Use of Acupuncture for the Treatment of Vulvar Vestibulitis Completed NCT02362763 Not Applicable
22 Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia Completed NCT01455350 Not Applicable lidocaine
23 Pilot Study to Assess the Efficacy of Cognitive-behavioral Couple Therapy for Provoked Vestibulodynia Completed NCT01582373 Not Applicable
24 Vulvar Vestibulitis Clinical Trial: Desipramine-Lidocaine Completed NCT00276068 Not Applicable topical lidocaine + oral desipramine, and/or placebo
25 Long-Term Assessment of Quality of Life and Effectiveness of Onabotulinumtoxina Injections in Provoked Vestibulodynia Completed NCT02858375
26 Efficacy of Transcranial Direct-Current Stimulation (tDCS) for Provoked Vestibulodynia : a Triple Blind Randomized Controlled Trial Completed NCT02543593 Not Applicable
27 "Vestibulitis Educational Seminar Trial" Study Completed NCT00278850
28 A Search for Helicobacter Pylori in Localized Vulvodynia Completed NCT00501774
29 Pregnancy, Childbirth Intentions and Outcomes Under Sexual Pain Completed NCT01731288
30 Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest. Completed NCT01517516
31 Acupuncture for the Treatment of Vulvodynia Completed NCT02197429 Not Applicable
32 Acupuncture for Vulvodynia: A Pre-pilot Study Completed NCT02704234 Not Applicable
33 Outcomes of Delivery in Patients With Dyspareunia Completed NCT01753258
34 The Effectiveness of Vestibulectomy Completed NCT00873301 Not Applicable
35 Physiotherapy Intervention for Provoked Vulvar Vestibulodynia Recruiting NCT01628679 Not Applicable
36 Lipofilling as a Treatment for Vestibulodynia Recruiting NCT03431779 Not Applicable
37 Subtypes of Provoked Vestibulodynia Recruiting NCT02712814 Topical hormonal cream (estrogen)
38 The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia Recruiting NCT02892214 estriol cream (ovestin)
39 Effect of Acupuncture on Patient Vulvodynia Outcomes Recruiting NCT03364127 Not Applicable
40 Effect of Two Acupuncture Protocols on Vulvodynia Recruiting NCT03481621 Not Applicable
41 Innovations in the Treatment of Sexual Health Post Prostate Cancer Treatment: Comparing Mindfulness vs. CBT Recruiting NCT03365518 Not Applicable
42 Study to Compare the Efficacy of Cognitive-behavioral Couple Therapy and Lidocaine for Provoked Vestibulodynia Active, not recruiting NCT01935063 Not Applicable
43 Intimacy and Mindfulness Post-Prostate Cancer Treatment Active, not recruiting NCT03177707 Not Applicable
44 Randomized Comparison of Mindfulness Versus Group Support for Treatment of Low Sexual Desire in Women Active, not recruiting NCT01690897 Not Applicable
45 Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia Terminated NCT01149031 Not Applicable
46 Cold Laser: A Modality to Promote Vulvar Healing and Pain Relief Terminated NCT02204319 Not Applicable
47 Study of Emu Oil vs. Placebo for Vulvar Pain in Women. Terminated NCT01295268 Not Applicable
48 Hormonal Contraceptive Use and the Risk of Provoked Vestibulodynia Withdrawn NCT01741948 Hormonal contraceptive
49 Randomized CO2 vs Sham Laser Treatment of Provoked Vestibulodynia Withdrawn NCT03390049 Not Applicable

Search NIH Clinical Center for Vulvar Vestibulitis Syndrome

Genetic Tests for Vulvar Vestibulitis Syndrome

Anatomical Context for Vulvar Vestibulitis Syndrome

MalaCards organs/tissues related to Vulvar Vestibulitis Syndrome:

42
Brain, Testes

Publications for Vulvar Vestibulitis Syndrome

Articles related to Vulvar Vestibulitis Syndrome:

(show top 50) (show all 87)
# Title Authors Year
1
The bacterial microbiome in paired vaginal and vestibular samples from women with vulvar vestibulitis syndrome. ( 24961922 )
2014
2
Elevated tissue levels of tumor necrosis factor-I+ in vulvar vestibulitis syndrome. ( 25551965 )
2014
3
Sacral neuromodulation in the treatment of vulvar vestibulitis syndrome. ( 19622972 )
2009
4
Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. ( 19254587 )
2009
5
Botulinum neurotoxin type A injections for vaginismus secondary to vulvar vestibulitis syndrome. ( 20168100 )
2009
6
Overlap between orofacial pain and vulvar vestibulitis syndrome. ( 18287822 )
2008
7
Association between primary vulvar vestibulitis syndrome, defective induction of tumor necrosis factor-alpha, and carriage of the mannose-binding lectin codon 54 gene polymorphism. ( 18166320 )
2008
8
Somatization and psychological distress among women with vulvar vestibulitis syndrome. ( 18635182 )
2008
9
Multilevel local anesthetic nerve blockade for the treatment of vulvar vestibulitis syndrome. ( 17936236 )
2008
10
Vulvar vestibulitis syndrome and estrogen dose of oral contraceptive pills. ( 17970976 )
2007
11
Effectiveness of hypnosis for the treatment of vulvar vestibulitis syndrome: a preliminary investigation. ( 17367437 )
2007
12
Effects of sexual arousal on genital and non-genital sensation: a comparison of women with vulvar vestibulitis syndrome and healthy controls. ( 17136588 )
2007
13
Human papillomavirus in vulvar vestibulitis syndrome. ( 17694965 )
2007
14
Surgical treatment of vulvar vestibulitis syndrome: outcome assessment derived from a postoperative questionnaire. ( 16942537 )
2006
15
A cognitive-behavioral group program for women with vulvar vestibulitis syndrome (VVS): factors associated with treatment success. ( 16809249 )
2006
16
Vulvar vestibulitis syndrome. ( 17064641 )
2006
17
Tender point examination in women with vulvar vestibulitis syndrome. ( 16926575 )
2006
18
Surgical techniques: Surgery for Vulvar Vestibulitis syndrome. ( 16681483 )
2006
19
Surgical treatment for the vulvar vestibulitis syndrome. ( 16449109 )
2006
20
A conceptual model for the pathophysiology of vulvar vestibulitis syndrome. ( 16719941 )
2006
21
Hyperoxaluria in women with vulvar vestibulitis syndrome. ( 16846091 )
2006
22
Psychological factors associated with perception of experimental pain in vulvar vestibulitis syndrome. ( 16020147 )
2005
23
Vulvar vestibulitis syndrome: a review. ( 15927350 )
2005
24
Vulvar vestibulitis syndrome: an important factor in the evaluation of lifelong vaginismus? ( 16457419 )
2005
25
Personality traits associated with perception of noxious stimuli in women with vulvar vestibulitis syndrome. ( 15772910 )
2005
26
Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome. ( 15836975 )
2005
27
Psychological aspects of vulvar vestibulitis syndrome. ( 16050535 )
2005
28
The major histopathologic characteristics in the vulvar vestibulitis syndrome. ( 15542936 )
2005
29
Pelvic floor muscle functioning in women with vulvar vestibulitis syndrome. ( 16050536 )
2005
30
Childhood nocturnal enuresis in vulvar vestibulitis syndrome. ( 15730174 )
2005
31
To cut or not to cut: treatment of vulvar vestibulitis syndrome. ( 15376407 )
2004
32
Impact of genetic variation in interleukin-1 receptor antagonist and melanocortin-1 receptor genes on vulvar vestibulitis syndrome. ( 15305821 )
2004
33
A new instrument for pain assessment in vulvar vestibulitis syndrome. ( 15043051 )
2004
34
Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome. ( 15467537 )
2004
35
Vulvar vestibulitis syndrome: a clinical approach. ( 15205070 )
2004
36
Capsaicin and the treatment of vulvar vestibulitis syndrome: a valuable alternative? ( 15775875 )
2004
37
Immunoglobulin E antibodies to seminal fluid in women with vulvar vestibulitis syndrome: relation to onset and timing of symptoms. ( 15041996 )
2004
38
Primary and secondary vulvar vestibulitis syndrome: systemic pain perception and psychophysical characteristics. ( 15295354 )
2004
39
Association between quantitative sensory testing, treatment choice, and subsequent pain reduction in vulvar vestibulitis syndrome. ( 15162345 )
2004
40
Estrogen receptor expression in vulvar vestibulitis syndrome. ( 14520218 )
2003
41
Hypnotherapy as a treatment for vulvar vestibulitis syndrome: a case report. ( 12851128 )
2003
42
Interleukin-1beta gene polymorphism in women with vulvar vestibulitis syndrome. ( 12593899 )
2003
43
Psychological profiles among women with vulvar vestibulitis syndrome: a chart review. ( 14584306 )
2003
44
Vestibular tactile and pain thresholds in women with vulvar vestibulitis syndrome. ( 11932072 )
2002
45
Physical therapy for vulvar vestibulitis syndrome: a retrospective study. ( 11995597 )
2002
46
Defective regulation of the proinflammatory immune response in women with vulvar vestibulitis syndrome. ( 11967493 )
2002
47
In favor of an integrated pain-relief treatment approach for vulvar vestibulitis syndrome. ( 12061041 )
2002
48
Differential characterization of women with vulvar vestibulitis syndrome. ( 12237632 )
2002
49
Web-enabled Glazer surface electromyographic protocol for the remote, real-time assessment and rehabilitation of pelvic floor dysfunction in vulvar vestibulitis syndrome. A case report. ( 12380455 )
2002
50
Vulvar vestibulitis syndrome: care made to measure. ( 12061037 )
2002

Variations for Vulvar Vestibulitis Syndrome

Expression for Vulvar Vestibulitis Syndrome

Search GEO for disease gene expression data for Vulvar Vestibulitis Syndrome.

Pathways for Vulvar Vestibulitis Syndrome

Pathways related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 IL1B MBL2 NLRP3 TNF
2 12.36 IL1B IL1RN TNF
3
Show member pathways
12.27 ESR1 IL1B IL1RN
4
Show member pathways
12.1 IL1B IL1R1 TNF
5
Show member pathways
12.08 IL1B IL1R1 IL1RN
6
Show member pathways
12 IL1B NLRP3 TNF
7
Show member pathways
11.99 IL1B NLRP3 TNF
8
Show member pathways
11.96 IL1B IL1R1 TNF
9 11.95 IL1B IL1RN TNF
10 11.86 IL1B IL1R1 TNF
11
Show member pathways
11.81 IL1B IL1R1 TNF
12 11.79 IL1B IL1R1 TNF
13 11.75 IL1B IL1R1 TNF
14
Show member pathways
11.7 IL1B IL1R1 IL1RN TNF
15 11.64 IL1B IL1R1 TNF
16 11.62 IL1B IL1R1 TNF
17 11.59 IL1B IL1R1 TNF
18 11.48 IL1B IL1R1 TNF
19 11.43 IL1B NLRP3 TNF
20 11.36 IL1B TNF
21 11.35 IL1B IL1RN TNF
22 11.34 ESR1 TNF
23 11.34 IL1B TNF
24 11.34 IL1B TNF
25 11.3 IL1B TNF
26 11.25 IL1B NLRP3
27 11.21 IL1B TNF
28 11.18 IL1B TNF
29 11.13 IL1B TNF
30 11.11 IL1B TNF
31 11.07 IL1B TNF
32
Show member pathways
11.07 IL1B IL1R1 TNF
33 10.93 IL1B TNF
34 10.75 IL1B TNF
35 10.61 IL1B IL1R1 IL1RN TNF
36 10.53 IL1B IL1R1 NLRP3

GO Terms for Vulvar Vestibulitis Syndrome

Cellular components related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 IL1B IL1R1 IL1RN MBL2 NLRP3 TNF

Biological processes related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.93 IL1B IL1R1 IL1RN TNF
2 cytokine-mediated signaling pathway GO:0019221 9.86 IL1B IL1R1 IL1RN TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.83 IL1B IL1RN TNF
4 positive regulation of protein kinase B signaling GO:0051897 9.83 ESR1 MC1R TNF
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.81 IL1B NLRP3 TNF
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.78 ESR1 IL1B TNF
7 defense response to Gram-positive bacterium GO:0050830 9.77 MBL2 NLRP3 TNF
8 positive regulation of JNK cascade GO:0046330 9.75 IL1B IL1RN TNF
9 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.68 NLRP3 TNF
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.68 IL1B TNF
11 protein kinase B signaling GO:0043491 9.68 IL1B TNF
12 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.68 IL1B TNF
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 IL1B TNF
14 positive regulation of interleukin-8 production GO:0032757 9.67 IL1B TNF
15 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B IL1RN TNF
16 negative regulation of neurogenesis GO:0050768 9.66 IL1B TNF
17 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
18 positive regulation of glial cell proliferation GO:0060252 9.65 IL1B TNF
19 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.64 IL1B TNF
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 IL1B TNF
21 interleukin-1-mediated signaling pathway GO:0070498 9.63 IL1B IL1R1 IL1RN
22 negative regulation of growth of symbiont in host GO:0044130 9.62 MBL2 TNF
23 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL1B TNF
24 positive regulation of chemokine biosynthetic process GO:0045080 9.59 IL1B TNF
25 regulation of establishment of endothelial barrier GO:1903140 9.58 IL1B TNF
26 positive regulation of interferon-gamma production GO:0032729 9.58 IL1B IL1R1 TNF
27 positive regulation of neuroinflammatory response GO:0150078 9.57 IL1B TNF
28 cellular response to lipopolysaccharide GO:0071222 9.56 IL1B IL1RN NLRP3 TNF
29 interleukin-1 beta production GO:0032611 9.55 IL1B NLRP3
30 inflammatory response GO:0006954 9.55 IL1B IL1R1 IL1RN NLRP3 TNF
31 positive regulation of fever generation GO:0031622 9.54 IL1B TNF
32 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.52 IL1B IL1R1
33 response to glucocorticoid GO:0051384 9.51 IL1RN TNF
34 positive regulation of phagocytosis GO:0050766 9.5 IL1B MBL2 TNF
35 sequestering of triglyceride GO:0030730 9.48 IL1B TNF
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 IL1B TNF
37 response to interleukin-1 GO:0070555 9.37 IL1R1
38 regulation of inflammatory response GO:0050727 9.26 ESR1 IL1R1 NLRP3 TNF
39 positive regulation of JUN kinase activity GO:0043507 9.07 TNF
40 chronic inflammatory response to antigenic stimulus GO:0002439 8.32 TNF
41 signal transduction GO:0007165 10.09 ESR1 IL1B IL1R1 MC1R NLRP3
42 positive regulation of transcription by RNA polymerase II GO:0045944 10.01 ESR1 IL1B MC1R NLRP3 TNF

Molecular functions related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL1B IL1RN TNF
2 interleukin-1 receptor binding GO:0005149 8.62 IL1B IL1RN

Sources for Vulvar Vestibulitis Syndrome

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