MCID: VLV042
MIFTS: 20

Vulvar Vestibulitis Syndrome

Categories: Rare diseases
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Aliases & Classifications for Vulvar Vestibulitis Syndrome

MalaCards integrated aliases for Vulvar Vestibulitis Syndrome:

Name: Vulvar Vestibulitis Syndrome 19
Vulvar Vestibulitis 71 75

Classifications:



External Ids:

UMLS 71 C0269084

Summaries for Vulvar Vestibulitis Syndrome

MalaCards based summary: Vulvar Vestibulitis Syndrome, also known as vulvar vestibulitis, is related to paine syndrome and candidiasis. The drugs Capsaicin and Tomato have been mentioned in the context of this disorder.

Wikipedia: 75 Vulvar vestibulitis syndrome (VVS), vestibulodynia, or simply vulvar vestibulitis, is vulvodynia... more...

Related Diseases for Vulvar Vestibulitis Syndrome

Graphical network of the top 20 diseases related to Vulvar Vestibulitis Syndrome:



Diseases related to Vulvar Vestibulitis Syndrome

Symptoms & Phenotypes for Vulvar Vestibulitis Syndrome

Drugs & Therapeutics for Vulvar Vestibulitis Syndrome

Drugs for Vulvar Vestibulitis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 2, Phase 3 404-86-4 1548943
2 Tomato Approved Phase 3
3
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
4
Nifedipine Approved Phase 3 21829-25-4 4485
5
Milnacipran Approved, Investigational Phase 3 92623-85-3, 96847-54-0 11622909 65833 6917779
6
Norepinephrine Approved Phase 3 51-41-2 439260
7 Cholinergic Agents Phase 3
8
abobotulinumtoxinA Phase 3
9 Botulinum Toxins, Type A Phase 3
10 Botulinum Toxins Phase 3
11 Neurotransmitter Agents Phase 3
12 Tocolytic Agents Phase 3
13 Vasodilator Agents Phase 3
14 Antidepressive Agents Phase 3
15 Psychotropic Drugs Phase 3
16 Analgesics Phase 3
17 Pharmaceutical Solutions Phase 3
18 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
19 Analgesics, Non-Narcotic Phase 3
20
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
21
Heparin, bovine Approved, Investigational, Withdrawn Phase 2 9005-49-6 22833565 9812414 772
22
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
23
Polyestradiol phosphate Approved Phase 2 28014-46-2
24
Nortriptyline Approved Phase 2 72-69-5 4543
25
Petrolatum Approved, Investigational Phase 2 8009-03-8
26
Pregabalin Approved, Investigational Phase 2 148553-50-8 5486971
27 Fibrinolytic Agents Phase 2
28 Anticoagulants Phase 2
29 Adrenergic Agents Phase 2
30 Antidepressive Agents, Tricyclic Phase 2
31 Estradiol 3-benzoate Phase 2
32 Estradiol 17 beta-cypionate Phase 2
33 Estrogens Phase 2
34 Hormone Antagonists Phase 2
35 Calcium, Dietary Phase 2
36 calcium channel blockers Phase 2
37 Anesthetics, Local Phase 2
38 Sodium Channel Blockers Phase 2
39 Anesthetics Phase 2
40 Anti-Arrhythmia Agents Phase 2
41 Diuretics, Potassium Sparing Phase 2
42 Anticonvulsants Phase 2
43 Anti-Anxiety Agents Phase 2
44 Tea Phase 2
45 Tin Fluorides Phase 2
46
Calcium Nutraceutical Phase 2 7440-70-2 271
47
Desipramine Approved, Investigational 50-47-5 2995
48
Esomeprazole Approved, Investigational, Vet_approved 73590-58-6, 119141-88-7 9568614 4594
49
Epitestosterone Approved, Experimental, Investigational 481-30-1, 58-22-0 5408 10204 6013
50
Ropivacaine Approved 84057-95-4 71273 175805

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4 Botulinum toxin
2 Dysbiosis in the Vaginal Microbiota May be Associated With the Development of Localized Provoked Vulvodynia (LPV) Unknown status NCT02393911 Phase 3
3 A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia Unknown status NCT02854670 Phase 2, Phase 3 Capsaicin patch
4 A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia Unknown status NCT02858219 Phase 3 Botulinum Toxin Type A
5 Topical Application of Nifedipine Cream for the Treatment of Vulvar Vestibulitis Syndrome Completed NCT00496184 Phase 3 Nifedipine cream topical application
6 Double Blind Placebo-controlled RCT of the Efficacy and Safety of Intramuscular Injections of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia Completed NCT02773641 Phase 3 Botulinum Toxin Type A;Sterile Saline Solution
7 An Open Label Trial of Milnacipran in the Treatment of Women With Provoked Vestibulodynia Completed NCT01304589 Phase 3 Milnacipran
8 Double Blind Placebo-controlled RCT of the Efficacy and Safety of Intramuscular Injections of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia Completed NCT04057755 Phase 3 botulinum toxin A;NaCl
9 Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis Completed NCT00004316 Phase 1, Phase 2 capsaicin
10 Enoxaparin as Treatment for Vulvar Vestibulitis Syndrome - Vulvodynia Completed NCT00874484 Phase 2 Clexane (enoxaparin)
11 Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments Recruiting NCT03844412 Phase 2 5% lidocaine/5 mg/ml 0.02% estradiol compound cream;Nortriptyline;Placebo cream;Placebo pill
12 Use of 5% Lidocaine Ointment in the Treatment of Vulvar Vestibulitis Terminated NCT00450242 Phase 2 5% topical lidocaine ointment;Placebo cream
13 Pregabalin (Lyrica) for the Treatment of Vulvodynia: A Randomized, Double-blinded, Placebo-controlled Cross-over Study Terminated NCT00853229 Phase 2 pregabalin
14 Sinecatechins Ointment, a Botanical Drug Derived From Green Tea, for the Treatment of Significant to Severe Secondary Provoked Vestibulodynia in Sexually Active, Post-Menopausal Women With Vulvovaginal Atrophy Terminated NCT03682601 Phase 2 5% sinecatechins ointment;Placebo;10% sinecatechins ointment
15 Acupuncture Augmentation of Lidocaine for the Treatment of Provoked, Localized vulvodynia-a Feasibility and Acceptability Pilot Study Completed NCT01996384 Phase 1 Lidocaine
16 Pilot Clinical Trial of Two Acupuncture Protocols on Vulvodynia Unknown status NCT03481621
17 A Guided Internet-based CBT Treatment for Provoked Vestibulodynia:a Randomized Controlled Trial Unknown status NCT04045041
18 Adipose Derived Stem Cell Transplantation Via Lipofilling for Vestibulodynia: a Controlled Intervention Study Unknown status NCT03431779
19 Vulvar Vestibulitis Trial: Desipramine-Lidocaine Completed NCT00276068 topical lidocaine + oral desipramine, and/or placebo
20 The Use of Acupuncture for the Treatment of Vulvar Vestibulitis Completed NCT02362763
21 Acupuncture for Vulvodynia: A Double-blinded Feasibility Pre-pilot Study Completed NCT02704234
22 Acupuncture for the Treatment of Vulvodynia Completed NCT02197429
23 A Laboratory and Clinical Search for the Presence of H. Pylori and Treatment Against it in Localized Vulvodynia (Vestibulitis, Vestibulodynia). Completed NCT00501774
24 "Vestibulitis Educational Seminar Trial" Study Completed NCT00278850
25 A Randomized Comparison of Individual Cognitive-behavioural Therapy and Pelvic Floor Rehabilitation in the Treatment of Provoked Vestibulodynia Completed NCT02494934
26 Pilot Study to Assess the Efficacy of an Experimental 12-week Cognitive-behavioral Couple Therapy in the Treatment of Provoked Vestibulodynia Completed NCT01582373
27 Efficacy of Treatments for Provoked Vestivulodynia : a Randomised Clinical Trial Comparing Multimodal Physiotherapy Treatments to Topical Lidocaine Completed NCT01455350 lidocaine
28 Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia Completed NCT01704456
29 A Feasibility and Acceptability Study of High-level Laser for Women With Provoked Vestibulodynia Completed NCT04502810
30 Integrated Mindfulness for Provoked Vestibulodynia Completed NCT01704443
31 Somatocognitive Therapy in Treatment of Provoked Vestibulodynia - Process of Change and User Experience Completed NCT04208204
32 Subtypes of Provoked Vestibulodynia: A Prospective Study to Evaluate a Diagnostic Algorithm in Regard to Different Treatment Modalities Completed NCT02712814 Topical hormonal cream (estrogen)
33 The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia, and the Mental Health of the Patient Completed NCT02892214 estriol cream (ovestin)
34 Pregnancy, Childbirth Intentions and Outcomes Under Sexual Pain Completed NCT01731288
35 Long-Term Assessment of Quality of Life and Effectiveness of Onabotulinumtoxina Injections in Provoked Vestibulodynia Completed NCT02858375
36 A Comparison of Cognitive-behavioral Couple Therapy and Lidocaine in the Treatment of Provoked Vestibulodynia: A Randomized Clinical Trial Completed NCT01935063
37 Outcomes of Delivery in Patients With Dyspareunia- A Prospective Study Completed NCT01753258
38 The Application of External Fractional CO2 Laser Energy Versus Topical Lidocaine for the Treatment of Vestibulodynia in Premenopausal Women on Hormonal Contraception: a Pilot Study Completed NCT05336825 Lidocaine patch 5%
39 Efficacy of Transcranial Direct-Current Stimulation (tDCS) for Provoked Vestibulodynia : a Triple Blind Randomized Controlled Trial Completed NCT02543593
40 The Use of Low Intensity Shock Wave Therapy for the Treatment of Provoked Vestibulodynia Disorder (PVD) Completed NCT04545255
41 Physiotherapy Intervention for Provoked Vulvar Vestibulodynia Completed NCT01628679
42 Double-blind Phase 2 RCT: Effect of Acupuncture on Patient Vulvodynia Outcomes Recruiting NCT03364127
43 Is Low Level Laser Therapy (LLLT) Effective for Reducing Pain Experienced by Women With Provoked Vestibulodynia? Recruiting NCT04234542
44 Effectiveness and Cost-utility of Somatocognitive Therapy Versus Treatment as Usual for Provoked (Localized) Vestibulodynia - a Randomized Clinical Trial (ProLoVe Study) Recruiting NCT04613713
45 Effects of Flourish HEC Vaginal Care System on Reduction of Pain in Women With Localized Provoked Vulvodynia Enrolling by invitation NCT05478746
46 An Open-Label, Interventional, Not Controlled Pilot Study to Assess Vestibular Mucosa Thickness by Ultrasound Evaluation and Vestibular Perception Thresholds Changes in Women Affected by Vestibulodynia (VBD) After One Cycle of Pixel CO2-Alma Fractionated Laser Not yet recruiting NCT05156489
47 Assessing the Feasibility of Somatosensory Rehabilitation and Pain Management Programs in Women With Provoked Vestibulodynia Not yet recruiting NCT05342402
48 Cold Laser: A Modality to Promote Vulvar Healing and Pain Relief Terminated NCT02204319
49 Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia Terminated NCT01149031
50 The Efficacy of Emu Oil vs. Placebo in Minimizing Vulvar Pain Levels in Women--A Randomized, Double Blinded, Placebo-Controlled Trial. Terminated NCT01295268

Search NIH Clinical Center for Vulvar Vestibulitis Syndrome

Genetic Tests for Vulvar Vestibulitis Syndrome

Anatomical Context for Vulvar Vestibulitis Syndrome

Publications for Vulvar Vestibulitis Syndrome

Articles related to Vulvar Vestibulitis Syndrome:

(show top 50) (show all 273)
# Title Authors PMID Year
1
A genetic polymorphism that is associated with mitochondrial energy metabolism increases risk of fibromyalgia. 62
32658146 2020
2
The Vulvodynia Experience Questionnaire: Qualitative Development of a New Patient-Reported Outcome Measure for Vulvodynia. 62
32900670 2020
3
Vulvodynia: A Review of the Literature. 62
34861006 2019
4
Inhalant allergy compounding the chronic vaginitis syndrome: characterization of sensitization patterns, comorbidities and responses to sublingual immunotherapy. 62
27040422 2016
5
Hormonal contraception and pelvic floor function: a systematic review. 62
26407563 2016
6
Value of Quantitative Sensory Testing in the Evaluation of Genital Sensation: Its Application to Female Sexual Dysfunction. 62
27530381 2016
7
The bacterial microbiome in paired vaginal and vestibular samples from women with vulvar vestibulitis syndrome. 62
24961922 2014
8
Polymorphisms of the androgen receptor gene and hormonal contraceptive induced provoked vestibulodynia. 62
25187224 2014
9
Elevated tissue levels of tumor necrosis factor-α in vulvar vestibulitis syndrome. 62
25551965 2014
10
Long-term well-being after surgical or conservative treatment of severe vulvar vestibulitis. 62
22621618 2012
11
Long-term follow up of posterior vestibulectomy for treating vulvar vestibulitis. 62
21793812 2011
12
Sacral neuromodulation stimulation for IC/PBS, chronic pelvic pain, and sexual dysfunction. 62
20972541 2010
13
Surgical treatment of vulvar vestibulitis: a review. 62
20955094 2010
14
Botulinum neurotoxin type A injections for vaginismus secondary to vulvar vestibulitis syndrome. 62
20168100 2009
15
Sacral neuromodulation in the treatment of vulvar vestibulitis syndrome. 62
19622972 2009
16
Investigation of the sensitivity of a cross-polarized light visualization system to detect subclinical erythema and dryness in women with vulvovaginitis. 62
19393601 2009
17
Incidence of Bartholin's duct occlusion after superficial localized vestibulectomy. 62
19376494 2009
18
Genito-sensory analysis in women with arousal and orgasmic dysfunction. 62
19207274 2009
19
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness. 62
19305326 2009
20
Chronic stress in women with localised provoked vulvodynia. 62
19308786 2009
21
HPV infection in women: psychosexual impact of genital warts and intraepithelial lesions. 62
19170869 2009
22
Open-label trial of lamotrigine focusing on efficacy in vulvodynia. 62
19370903 2009
23
Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. 62
19254587 2009
24
Central nervous system abnormalities in vaginismus. 62
19071060 2009
25
[Assessment of painful sexual intercourse occurrence among women in gynaecological practice]. 62
19140499 2008
26
Somatization and psychological distress among women with vulvar vestibulitis syndrome. 62
18635182 2008
27
Vulvar pain: a phenomenological study of couples in search of effective diagnosis and treatment. 62
18605118 2008
28
[On the need for biopsy in vulvar vestibulitis?]. 62
18457719 2008
29
[Vulvar vestibulitis syndrome: a clinicopathological study of 14 cases]. 62
18457722 2008
30
[Perception of chronic pelvic pain in women: predictors and clinical implications]. 62
21086354 2008
31
Overlap between orofacial pain and vulvar vestibulitis syndrome. 62
18287822 2008
32
Involvement of heparanase in the pathogenesis of localized vulvodynia. 62
18156988 2008
33
Multilevel local anesthetic nerve blockade for the treatment of vulvar vestibulitis syndrome. 62
17936236 2008
34
Association between primary vulvar vestibulitis syndrome, defective induction of tumor necrosis factor-alpha, and carriage of the mannose-binding lectin codon 54 gene polymorphism. 62
18166320 2008
35
Vulvodynia. 62
18173761 2008
36
Post-coital burning pain and pain at micturition: early symptoms of partial vaginismus with or without vulvar vestibulitis? 62
18770111 2008
37
A search for Helicobacter pyloriin localized vulvodynia. 62
18535389 2008
38
Bladder and bowel symptoms among women with vulvar disease: are they universal? 62
18210896 2007
39
Vulvovaginal chronic graft-versus-host disease with allogeneic hematopoietic stem cell transplantation. 62
17978118 2007
40
Vulvar vestibulitis syndrome and estrogen dose of oral contraceptive pills. 62
17970976 2007
41
Improvement in vulvar vestibulitis with montelukast. 62
17977165 2007
42
Surgery combined with muscle therapy for dyspareunia from vulvar vestibulitis: an observational study. 62
17847757 2007
43
Human papillomavirus in vulvar vestibulitis syndrome. 62
17694965 2007
44
Effects of sexual arousal on genital and non-genital sensation: a comparison of women with vulvar vestibulitis syndrome and healthy controls. 62
17136588 2007
45
Enhanced synthesis of proinflammatory cytokines by vulvar vestibular fibroblasts: implications for vulvar vestibulitis. 62
17403416 2007
46
Effectiveness of hypnosis for the treatment of vulvar vestibulitis syndrome: a preliminary investigation. 62
17367437 2007
47
Itch and burning pain in women with partial vaginismus with or without vulvar vestibulitis. 62
17365516 2007
48
Limbic associated pelvic pain: a hypothesis to explain the diagnostic relationships and features of patients with chronic pelvic pain. 62
17292560 2007
49
Vulvar vestibulitis and risk factors: a population-based case-control study in Oslo. 62
17598040 2007
50
Causes of chronic vaginitis: analysis of a prospective database of affected women. 62
17077241 2006

Variations for Vulvar Vestibulitis Syndrome

Expression for Vulvar Vestibulitis Syndrome

Search GEO for disease gene expression data for Vulvar Vestibulitis Syndrome.

Pathways for Vulvar Vestibulitis Syndrome

GO Terms for Vulvar Vestibulitis Syndrome

Sources for Vulvar Vestibulitis Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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