VVS
MCID: VLV042
MIFTS: 40

Vulvar Vestibulitis Syndrome (VVS)

Categories: Rare diseases

Aliases & Classifications for Vulvar Vestibulitis Syndrome

MalaCards integrated aliases for Vulvar Vestibulitis Syndrome:

Name: Vulvar Vestibulitis Syndrome 52
Vulvar Dysesthesia Localized in the Vestibule 52
Vulvar Vestibulitis 71
Vvs 52

Classifications:



External Ids:

UMLS 71 C0269084

Summaries for Vulvar Vestibulitis Syndrome

MalaCards based summary : Vulvar Vestibulitis Syndrome, also known as vulvar dysesthesia localized in the vestibule, is related to candidiasis and respiratory failure. An important gene associated with Vulvar Vestibulitis Syndrome is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Prolactin Signaling Pathway. The drugs Capsaicin and Tomato have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and lung, and related phenotypes are hematopoietic system and growth/size/body region

Wikipedia : 74 Vulvar vestibulitis syndrome (VVS), vestibulodynia, or simply vulvar vestibulitis, is vulvodynia... more...

Related Diseases for Vulvar Vestibulitis Syndrome

Diseases related to Vulvar Vestibulitis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 candidiasis 30.5 TNF MBL2 IL1B
2 respiratory failure 30.4 TNF IL1RN IL1R1 IL1B
3 chlamydia 29.9 TNF MBL2 IL1B
4 vulvovaginal candidiasis 29.9 NLRP3 MBL2 IL1RN
5 post-traumatic stress disorder 29.9 IL1RN IL1B ESR1
6 vaginitis 29.9 TNF IL1B ESR1
7 toxic shock syndrome 29.7 TNF IL1RN IL1R1 IL1B
8 bacterial vaginosis 29.7 TNF MBL2 IL1RN IL1B
9 syncope, familial vasovagal 12.4
10 vaccinia 11.6
11 syncope 11.3
12 chronic pain 10.5
13 progressive familial heart block, type ia 10.4
14 left bundle branch hemiblock 10.4
15 sexual disorder 10.3
16 prosthetic joint infection 10.3 MBL2 IL1B
17 bone sarcoma 10.3 IL1RN IL1R1
18 pars planitis 10.2 IL1RN IL1R1
19 staphylococcal toxic shock syndrome 10.2 TNF IL1B
20 palladium allergic contact dermatitis 10.2 TNF IL1B
21 kashin-beck disease 10.2 TNF IL1B
22 vulvovaginitis 10.2
23 papilloma 10.2
24 fibromyalgia 10.2
25 hypertonia 10.2
26 congenital cytomegalovirus 10.2 TNF IL1B
27 actinic prurigo 10.2 TNF IL1B
28 stachybotrys chartarum 10.2 TNF IL1B
29 eales disease 10.2 TNF IL1B
30 palindromic rheumatism 10.2 TNF IL1B
31 post-transplant lymphoproliferative disease 10.2 TNF IL1R1
32 irritant dermatitis 10.2 TNF IL1B
33 autoimmune vasculitis 10.2 TNF IL1B
34 juvenile ankylosing spondylitis 10.2 TNF IL1RN
35 periapical periodontitis 10.2 TNF IL1B
36 dental pulp disease 10.2 TNF IL1B
37 laryngitis 10.2 TNF IL1B
38 bagassosis 10.2 TNF IL1B
39 status asthmaticus 10.2 IL1RN IL1R1
40 lung cancer susceptibility 3 10.2
41 scoliosis 10.2
42 idiopathic scoliosis 10.2
43 compartment syndrome 10.2
44 influenza 10.2
45 lung disease 10.2
46 molluscum contagiosum 10.2
47 cardiogenic shock 10.2
48 glossitis 10.2 TNF IL1B
49 cardiac sarcoidosis 10.2 TNF IL1B
50 aortitis 10.2 TNF IL1RN

Graphical network of the top 20 diseases related to Vulvar Vestibulitis Syndrome:



Diseases related to Vulvar Vestibulitis Syndrome

Symptoms & Phenotypes for Vulvar Vestibulitis Syndrome

MGI Mouse Phenotypes related to Vulvar Vestibulitis Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 ESR1 IL1B IL1R1 IL1RN MBL2 MC1R
2 growth/size/body region MP:0005378 9.95 ESR1 IL1B IL1R1 IL1RN MC1R NLRP3
3 immune system MP:0005387 9.92 ESR1 IL1B IL1R1 IL1RN MBL2 MC1R
4 cardiovascular system MP:0005385 9.91 ESR1 IL1B IL1R1 IL1RN MC1R TNF
5 integument MP:0010771 9.8 ESR1 IL1B IL1R1 IL1RN MC1R NLRP3
6 limbs/digits/tail MP:0005371 9.55 ESR1 MBL2 MC1R NLRP3 TNF
7 neoplasm MP:0002006 9.35 ESR1 IL1B IL1R1 MC1R TNF
8 skeleton MP:0005390 9.17 ESR1 IL1B IL1R1 IL1RN MBL2 NLRP3

Drugs & Therapeutics for Vulvar Vestibulitis Syndrome

Drugs for Vulvar Vestibulitis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capsaicin Approved Phase 2, Phase 3 404-86-4 1548943
2 Tomato Approved Phase 3
3
Nifedipine Approved Phase 3 21829-25-4 4485
4
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
5
Norepinephrine Approved Phase 3 51-41-2 439260
6
Milnacipran Approved, Investigational Phase 3 92623-85-3 65833
7
Levomilnacipran Approved, Investigational Phase 3 96847-54-0
8 Antipruritics Phase 2, Phase 3
9 Tocolytic Agents Phase 3
10 Vasodilator Agents Phase 3
11 Neurotransmitter Agents Phase 3
12 Psychotropic Drugs Phase 3
13 Acetylcholine Release Inhibitors Phase 3
14 abobotulinumtoxinA Phase 3
15 Botulinum Toxins Phase 3
16 Cholinergic Agents Phase 3
17 Botulinum Toxins, Type A Phase 3
18 Antidepressive Agents Phase 3
19 Pharmaceutical Solutions Phase 3
20 Neuromuscular Agents Phase 3
21 Analgesics, Non-Narcotic Phase 3
22 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
23
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
24
Enoxaparin Approved Phase 2 9005-49-6 772
25
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
26
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
27
Nortriptyline Approved Phase 2 72-69-5 4543
28
Polyestradiol phosphate Approved Phase 2 28014-46-2
29
Tamoxifen Approved Phase 2 10540-29-1 2733526
30
Petrolatum Approved, Investigational Phase 2 8009-03-8
31
Pregabalin Approved, Investigational Phase 2 148553-50-8 5486971
32
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
33 Fibrinolytic Agents Phase 2
34 Anticoagulants Phase 2
35 Anti-Inflammatory Agents Phase 2
36 Anti-Bacterial Agents Phase 2
37 Anti-Inflammatory Agents, Non-Steroidal Phase 2
38 Immunologic Factors Phase 2
39 Anti-Infective Agents Phase 2
40 Angiogenesis Inhibitors Phase 2
41 Antirheumatic Agents Phase 2
42 Immunosuppressive Agents Phase 2
43 Contraceptive Agents Phase 2
44 Estrogens Phase 2
45 Estradiol 17 beta-cypionate Phase 2
46 Hormone Antagonists Phase 2
47 Estradiol 3-benzoate Phase 2
48 Antidepressive Agents, Tricyclic Phase 2
49 Adrenergic Agents Phase 2
50 Aromatase Inhibitors Phase 2

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4 Botulinum toxin
2 A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia Unknown status NCT02858219 Phase 3 Botulinum Toxin Type A
3 A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia Unknown status NCT02854670 Phase 2, Phase 3 Capsaicin patch
4 Dysbiosis in the Vaginal Microbiota May be Associated With the Development of Localized Provoked Vulvodynia (LPV) Unknown status NCT02393911 Phase 3
5 Topical Application of Nifedipine Cream for the Treatment of Vulvar Vestibulitis Syndrome Completed NCT00496184 Phase 3 Nifedipine cream topical application
6 An Open Label Trial of Milnacipran in the Treatment of Women With Provoked Vestibulodynia Completed NCT01304589 Phase 3 Milnacipran
7 Double Blind Placebo-controlled RCT of the Efficacy and Safety of Intramuscular Injections of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia Completed NCT04057755 Phase 3 botulinum toxin A;NaCl
8 Double Blind Placebo-controlled RCT of the Efficacy and Safety of Intramuscular Injections of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia Completed NCT02773641 Phase 3 Botulinum Toxin Type A;Sterile Saline Solution
9 Enoxaparin as Treatment for Vulvar Vestibulitis Syndrome - Vulvodynia Completed NCT00874484 Phase 2 Clexane (enoxaparin)
10 Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis Completed NCT00004316 Phase 1, Phase 2 capsaicin
11 A Clinical Trial Of CC-10004 For The Treatment Of Vulvodynia Completed NCT00814632 Phase 2 CC-10004
12 Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments Recruiting NCT03844412 Phase 2 5% lidocaine/5 mg/ml 0.02% estradiol compound cream;Nortriptyline;Placebo cream;Placebo pill
13 7.5% Sinecatechins Ointment, a Botanical Drug Derived From Green Tea, for the Treatment of Significant to Severe Secondary Provoked Vestibulodynia in Sexually Active, Post-Menopausal Women With Vulvovaginal Atrophy Recruiting NCT03682601 Phase 2 Sinecatechins Topical
14 Use of 5% Lidocaine Ointment in the Treatment of Vulvar Vestibulitis Terminated NCT00450242 Phase 2 5% topical lidocaine ointment;Placebo cream
15 Pregabalin (Lyrica) for the Treatment of Vulvodynia: A Randomized, Double-blinded, Placebo-controlled Cross-over Study Terminated NCT00853229 Phase 2 pregabalin
16 Acupuncture Augmentation of Lidocaine for the Treatment of Provoked, Localized vulvodynia-a Feasibility and Acceptability Pilot Study Completed NCT01996384 Phase 1 Lidocaine
17 "Vestibulitis Educational Seminar Trial" Study Completed NCT00278850
18 Acupuncture for the Treatment of Vulvodynia Completed NCT02197429
19 Long-Term Assessment of Quality of Life and Effectiveness of Onabotulinumtoxina Injections in Provoked Vestibulodynia Completed NCT02858375
20 The Effectiveness of Vestibulectomy Completed NCT00873301
21 Vulvar Vestibulitis Trial: Desipramine-Lidocaine Completed NCT00276068 topical lidocaine + oral desipramine, and/or placebo
22 The Use of Acupuncture for the Treatment of Vulvar Vestibulitis Completed NCT02362763
23 Outcomes of Delivery in Patients With Dyspareunia- A Prospective Study Completed NCT01753258
24 A Randomized Comparison of Individual Cognitive-behavioural Therapy and Pelvic Floor Rehabilitation in the Treatment of Provoked Vestibulodynia Completed NCT02494934
25 A Laboratory and Clinical Search for the Presence of H. Pylori and Treatment Against it in Localized Vulvodynia (Vestibulitis, Vestibulodynia). Completed NCT00501774
26 Integrated Mindfulness for Provoked Vestibulodynia Completed NCT01704443
27 Pregnancy, Childbirth Intentions and Outcomes Under Sexual Pain Completed NCT01731288
28 Efficacy of Treatments for Provoked Vestivulodynia : a Randomised Clinical Trial Comparing Multimodal Physiotherapy Treatments to Topical Lidocaine Completed NCT01455350 lidocaine
29 Efficacy of Transcranial Direct-Current Stimulation (tDCS) for Provoked Vestibulodynia : a Triple Blind Randomized Controlled Trial Completed NCT02543593
30 Acupuncture for Vulvodynia: A Double-blinded Feasibility Pre-pilot Study Completed NCT02704234
31 Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia Completed NCT01704456
32 Pilot Study to Assess the Efficacy of an Experimental 12-week Cognitive-behavioral Couple Therapy in the Treatment of Provoked Vestibulodynia Completed NCT01582373
33 Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Completed NCT02732145
34 Vaginal Cytokines in Postmenopausal Women With Symptoms of Vulvovaginal Irritation Completed NCT01899612
35 A Comparison of Cognitive-behavioral Couple Therapy and Lidocaine in the Treatment of Provoked Vestibulodynia: A Randomized Clinical Trial Completed NCT01935063
36 Treatment of Pain Using a Non-implanted Intra-vaginal Electrical Stimulation Device Compared to Sham Device in Chronic Pelvic Pain Completed NCT02397785
37 Adipose Derived Stem Cell Transplantation Via Lipofilling for Vestibulodynia: a Controlled Intervention Study Recruiting NCT03431779
38 The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia, and the Mental Health of the Patient Recruiting NCT02892214 estriol cream (ovestin)
39 Pilot Clinical Trial of Two Acupuncture Protocols on Vulvodynia Recruiting NCT03481621
40 Double-blind Phase 2 RCT: Effect of Acupuncture on Patient Vulvodynia Outcomes Recruiting NCT03364127
41 Subtypes of Provoked Vestibulodynia: A Prospective Study to Evaluate a Diagnostic Algorithm in Regard to Different Treatment Modalities Recruiting NCT02712814 Topical hormonal cream (estrogen)
42 Physiotherapy Intervention for Provoked Vulvar Vestibulodynia Active, not recruiting NCT01628679
43 A Guided Internet-based CBT Treatment for Provoked Vestibulodynia:a Randomized Controlled Trial Enrolling by invitation NCT04045041
44 Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia Terminated NCT01149031
45 Vulvar Pain: Treatment Trial Using Gabapentin-placebo in a Cross-over Design, Pilot Study. Terminated NCT00390013 Gabapentin;Placebo oral capsule
46 Cold Laser: A Modality to Promote Vulvar Healing and Pain Relief Terminated NCT02204319
47 The Efficacy of Emu Oil vs. Placebo in Minimizing Vulvar Pain Levels in Women--A Randomized, Double Blinded, Placebo-Controlled Trial. Terminated NCT01295268
48 Hormonal Contraceptive Use and the Risk of Provoked Vestibulodynia- A Prospective Study Withdrawn NCT01741948 Hormonal contraceptive
49 Randomized Controlled Trial of Fractional CO2 Laser vs Sham Laser for Women With Provoked Vestibulodynia Who Have Failed Conservative Management Withdrawn NCT03390049

Search NIH Clinical Center for Vulvar Vestibulitis Syndrome

Genetic Tests for Vulvar Vestibulitis Syndrome

Anatomical Context for Vulvar Vestibulitis Syndrome

MalaCards organs/tissues related to Vulvar Vestibulitis Syndrome:

40
Bone, Heart, Lung, Testes, Eye, Thyroid, Tonsil

Publications for Vulvar Vestibulitis Syndrome

Articles related to Vulvar Vestibulitis Syndrome:

(show top 50) (show all 270)
# Title Authors PMID Year
1
Inhalant allergy compounding the chronic vaginitis syndrome: characterization of sensitization patterns, comorbidities and responses to sublingual immunotherapy. 61
27040422 2016
2
Hormonal contraception and pelvic floor function: a systematic review. 61
26407563 2016
3
Value of Quantitative Sensory Testing in the Evaluation of Genital Sensation: Its Application to Female Sexual Dysfunction. 61
27530381 2016
4
The bacterial microbiome in paired vaginal and vestibular samples from women with vulvar vestibulitis syndrome. 61
24961922 2014
5
Polymorphisms of the androgen receptor gene and hormonal contraceptive induced provoked vestibulodynia. 61
25187224 2014
6
Elevated tissue levels of tumor necrosis factor-α in vulvar vestibulitis syndrome. 61
25551965 2014
7
Long-term well-being after surgical or conservative treatment of severe vulvar vestibulitis. 61
22621618 2012
8
Long-term follow up of posterior vestibulectomy for treating vulvar vestibulitis. 61
21793812 2011
9
Sacral neuromodulation stimulation for IC/PBS, chronic pelvic pain, and sexual dysfunction. 61
20972541 2010
10
Surgical treatment of vulvar vestibulitis: a review. 61
20955094 2010
11
Botulinum neurotoxin type A injections for vaginismus secondary to vulvar vestibulitis syndrome. 61
20168100 2009
12
Sacral neuromodulation in the treatment of vulvar vestibulitis syndrome. 61
19622972 2009
13
Investigation of the sensitivity of a cross-polarized light visualization system to detect subclinical erythema and dryness in women with vulvovaginitis. 61
19393601 2009
14
Incidence of Bartholin's duct occlusion after superficial localized vestibulectomy. 61
19376494 2009
15
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness. 61
19305326 2009
16
Genito-sensory analysis in women with arousal and orgasmic dysfunction. 61
19207274 2009
17
HPV infection in women: psychosexual impact of genital warts and intraepithelial lesions. 61
19170869 2009
18
Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. 61
19254587 2009
19
Open-label trial of lamotrigine focusing on efficacy in vulvodynia. 61
19370903 2009
20
Chronic stress in women with localised provoked vulvodynia. 61
19308786 2009
21
Central nervous system abnormalities in vaginismus. 61
19071060 2009
22
[Assessment of painful sexual intercourse occurrence among women in gynaecological practice]. 61
19140499 2008
23
Somatization and psychological distress among women with vulvar vestibulitis syndrome. 61
18635182 2008
24
Vulvar pain: a phenomenological study of couples in search of effective diagnosis and treatment. 61
18605118 2008
25
[Vulvar vestibulitis syndrome: a clinicopathological study of 14 cases]. 61
18457722 2008
26
[On the need for biopsy in vulvar vestibulitis?]. 61
18457719 2008
27
[Perception of chronic pelvic pain in women: predictors and clinical implications]. 61
21086354 2008
28
Overlap between orofacial pain and vulvar vestibulitis syndrome. 61
18287822 2008
29
Multilevel local anesthetic nerve blockade for the treatment of vulvar vestibulitis syndrome. 61
17936236 2008
30
Vulvodynia. 61
18173761 2008
31
Association between primary vulvar vestibulitis syndrome, defective induction of tumor necrosis factor-alpha, and carriage of the mannose-binding lectin codon 54 gene polymorphism. 61
18166320 2008
32
Involvement of heparanase in the pathogenesis of localized vulvodynia. 61
18156988 2008
33
A search for Helicobacter pyloriin localized vulvodynia. 61
18535389 2008
34
Post-coital burning pain and pain at micturition: early symptoms of partial vaginismus with or without vulvar vestibulitis? 61
18770111 2008
35
Bladder and bowel symptoms among women with vulvar disease: are they universal? 61
18210896 2007
36
Vulvovaginal chronic graft-versus-host disease with allogeneic hematopoietic stem cell transplantation. 61
17978118 2007
37
Vulvar vestibulitis syndrome and estrogen dose of oral contraceptive pills. 61
17970976 2007
38
Improvement in vulvar vestibulitis with montelukast. 61
17977165 2007
39
Surgery combined with muscle therapy for dyspareunia from vulvar vestibulitis: an observational study. 61
17847757 2007
40
Human papillomavirus in vulvar vestibulitis syndrome. 61
17694965 2007
41
Enhanced synthesis of proinflammatory cytokines by vulvar vestibular fibroblasts: implications for vulvar vestibulitis. 61
17403416 2007
42
Effects of sexual arousal on genital and non-genital sensation: a comparison of women with vulvar vestibulitis syndrome and healthy controls. 61
17136588 2007
43
Itch and burning pain in women with partial vaginismus with or without vulvar vestibulitis. 61
17365516 2007
44
Effectiveness of hypnosis for the treatment of vulvar vestibulitis syndrome: a preliminary investigation. 61
17367437 2007
45
Vulvar vestibulitis and risk factors: a population-based case-control study in Oslo. 61
17598040 2007
46
Limbic associated pelvic pain: a hypothesis to explain the diagnostic relationships and features of patients with chronic pelvic pain. 61
17292560 2007
47
Causes of chronic vaginitis: analysis of a prospective database of affected women. 61
17077241 2006
48
Vulvar vestibulitis syndrome. 61
17064641 2006
49
[Botulinum toxin for vulvar vestibulitis]. 61
17072204 2006
50
Surgical treatment of vulvar vestibulitis syndrome: outcome assessment derived from a postoperative questionnaire. 61
16942537 2006

Variations for Vulvar Vestibulitis Syndrome

Expression for Vulvar Vestibulitis Syndrome

Search GEO for disease gene expression data for Vulvar Vestibulitis Syndrome.

Pathways for Vulvar Vestibulitis Syndrome

Pathways related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 TNF NLRP3 MBL2 IL1B
2
Show member pathways
12.29 IL1RN IL1B ESR1
3
Show member pathways
12.12 TNF IL1R1 IL1B
4
Show member pathways
12.11 IL1RN IL1R1 IL1B
5 12.04 TNF NLRP3 IL1B
6 12.04 TNF NLRP3 IL1R1 IL1B
7
Show member pathways
12.02 TNF NLRP3 IL1B
8
Show member pathways
12.01 TNF NLRP3 IL1B
9
Show member pathways
11.98 TNF IL1R1 IL1B
10 11.97 TNF IL1RN IL1B
11 11.93 TNF NLRP3 IL1R1 IL1B
12 11.89 TNF IL1R1 IL1B
13
Show member pathways
11.85 TNF IL1R1 IL1B
14 11.83 TNF IL1R1 IL1B
15 11.79 TNF NLRP3 IL1B
16 11.78 TNF IL1R1 IL1B
17
Show member pathways
11.7 TNF IL1RN IL1R1 IL1B
18 11.69 TNF IL1R1 IL1B
19 11.68 TNF IL1R1 IL1B
20 11.65 TNF IL1R1 IL1B
21 11.54 TNF IL1R1 IL1B
22 11.49 TNF NLRP3 IL1B
23 11.43 TNF IL1RN IL1B
24 11.27 NLRP3 IL1B
25 11.22 TNF IL1B
26 11.19 TNF IL1B
27 11.14 TNF IL1B
28 11.12 TNF IL1B
29 11.09 TNF IL1B
30
Show member pathways
11.07 TNF IL1R1 IL1B
31 10.96 TNF IL1B
32 10.78 TNF IL1B
33 10.61 TNF IL1RN IL1R1 IL1B
34 10.53 NLRP3 IL1R1 IL1B

GO Terms for Vulvar Vestibulitis Syndrome

Cellular components related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 TNF NLRP3 MBL2 IL1RN IL1R1 IL1B

Biological processes related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.06 NLRP3 MC1R IL1RN IL1R1 IL1B ESR1
2 positive regulation of transcription by RNA polymerase II GO:0045944 10 TNF NLRP3 MC1R IL1B ESR1
3 immune response GO:0006955 9.91 TNF IL1RN IL1R1 IL1B
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.83 TNF IL1RN IL1B
5 positive regulation of protein kinase B signaling GO:0051897 9.83 TNF MC1R ESR1
6 cytokine-mediated signaling pathway GO:0019221 9.81 TNF IL1RN IL1R1 IL1B
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 TNF NLRP3 IL1B
8 positive regulation of DNA-binding transcription factor activity GO:0051091 9.74 TNF IL1B ESR1
9 defense response to Gram-positive bacterium GO:0050830 9.73 TNF NLRP3 MBL2
10 interleukin-1-mediated signaling pathway GO:0070498 9.72 IL1RN IL1R1 IL1B
11 positive regulation of JNK cascade GO:0046330 9.71 TNF IL1RN IL1B
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.68 TNF IL1B
13 response to interleukin-1 GO:0070555 9.68 IL1R1 IL1B
14 protein kinase B signaling GO:0043491 9.68 TNF IL1B
15 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.67 TNF IL1B
16 positive regulation of interleukin-6 secretion GO:2000778 9.67 TNF IL1B
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.67 TNF IL1B
18 negative regulation of neurogenesis GO:0050768 9.66 TNF IL1B
19 positive regulation of interleukin-8 production GO:0032757 9.66 TNF IL1B
20 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.65 TNF IL1B
21 positive regulation of glial cell proliferation GO:0060252 9.64 TNF IL1B
22 negative regulation of lipid catabolic process GO:0050995 9.64 TNF IL1B
23 astrocyte activation GO:0048143 9.63 TNF IL1B
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.62 TNF IL1B
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 TNF IL1B
26 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.61 TNF IL1B
27 positive regulation of interleukin-6 production GO:0032755 9.61 TNF IL1RN IL1B
28 positive regulation of neuroinflammatory response GO:0150078 9.59 TNF IL1B
29 positive regulation of chemokine biosynthetic process GO:0045080 9.58 TNF IL1B
30 regulation of establishment of endothelial barrier GO:1903140 9.52 TNF IL1B
31 positive regulation of phagocytosis GO:0050766 9.5 TNF MBL2 IL1B
32 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.49 IL1R1 IL1B
33 interleukin-1 beta production GO:0032611 9.48 NLRP3 IL1B
34 positive regulation of fever generation GO:0031622 9.46 TNF IL1B
35 cellular response to lipopolysaccharide GO:0071222 9.46 TNF NLRP3 IL1RN IL1B
36 positive regulation of interferon-gamma production GO:0032729 9.43 TNF IL1R1 IL1B
37 sequestering of triglyceride GO:0030730 9.4 TNF IL1B
38 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 TNF IL1B
39 inflammatory response GO:0006954 9.35 TNF NLRP3 IL1RN IL1R1 IL1B
40 regulation of inflammatory response GO:0050727 8.92 TNF NLRP3 IL1R1 ESR1

Molecular functions related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 TNF IL1RN IL1B
2 interleukin-1 receptor binding GO:0005149 8.62 IL1RN IL1B

Sources for Vulvar Vestibulitis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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