MCID: VLV042
MIFTS: 44

Vulvar Vestibulitis Syndrome

Categories: Rare diseases

Aliases & Classifications for Vulvar Vestibulitis Syndrome

MalaCards integrated aliases for Vulvar Vestibulitis Syndrome:

Name: Vulvar Vestibulitis Syndrome 53
Vulvar Dysesthesia Localized in the Vestibule 53
Vulvar Vestibulitis 73
Vvs 53

Classifications:



External Ids:

UMLS 73 C0269084

Summaries for Vulvar Vestibulitis Syndrome

MalaCards based summary : Vulvar Vestibulitis Syndrome, also known as vulvar dysesthesia localized in the vestibule, is related to vaginitis and vulvovaginal candidiasis. An important gene associated with Vulvar Vestibulitis Syndrome is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and NF-kappaB Signaling. The drugs Acetylcholine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include prostate, brain and testes, and related phenotypes are hematopoietic system and growth/size/body region

Wikipedia : 76 Vulvar vestibulitis syndrome (VVS), vestibulodynia, or simply vulvar vestibulitis, is vulvodynia... more...

Related Diseases for Vulvar Vestibulitis Syndrome

Diseases related to Vulvar Vestibulitis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 vaginitis 30.5 ESR1 IL1B
2 vulvovaginal candidiasis 29.9 MBL2 NLRP3
3 syncope, familial vasovagal 12.0
4 vaccinia 11.3
5 prosthetic joint infection 10.7 IL1B MBL2
6 gastric cancer, hereditary diffuse 10.6 IL1B IL1RN
7 systemic onset juvenile idiopathic arthritis 10.5 IL1B TNF
8 staphylococcal toxic shock syndrome 10.5 IL1B TNF
9 autoimmune myocarditis 10.5 IL1B TNF
10 kashin-beck disease 10.5 IL1B TNF
11 hydrarthrosis 10.5 IL1B IL1RN
12 burns 10.5 IL1B TNF
13 laryngitis 10.5 IL1B TNF
14 haemophilus influenzae 10.5 IL1B TNF
15 retinitis pigmentosa 60 10.5 IL1B TNF
16 irritant dermatitis 10.5 IL1B TNF
17 acute vascular insufficiency of intestine 10.5 IL1B TNF
18 actinic prurigo 10.5 IL1B TNF
19 poems syndrome 10.5 IL1B TNF
20 crohn's colitis 10.5 IL1B TNF
21 adult dermatomyositis 10.5 MBL2 TNF
22 central nervous system vasculitis 10.5 IL1B TNF
23 stachybotrys chartarum 10.4 IL1B TNF
24 endometrial disease 10.4 ESR1 IL1B
25 dental pulp disease 10.4 IL1B TNF
26 jejunoileitis 10.4 IL1B TNF
27 root resorption 10.4 IL1B IL1RN
28 spondylosis 10.4 ESR1 IL1B
29 listeriosis 10.4 MBL2 TNF
30 eales disease 10.4 IL1B TNF
31 scrub typhus 10.4 IL1B TNF
32 pulpitis 10.4 IL1B TNF
33 middle ear disease 10.4 IL1B TNF
34 pleural disease 10.4 IL1B TNF
35 commensal bacterial infectious disease 10.4 IL1B TNF
36 q fever 10.4 IL1B TNF
37 lacrimal apparatus disease 10.4 IL1B TNF
38 perinatal necrotizing enterocolitis 10.3 IL1B TNF
39 cellulitis 10.3 IL1R1 TNF
40 post-transplant lymphoproliferative disease 10.3 IL1R1 TNF
41 palindromic rheumatism 10.3 IL1B TNF
42 sweat gland disease 10.3 IL1RN TNF
43 extrinsic cardiomyopathy 10.3 IL1B TNF
44 viral encephalitis 10.3 IL1B TNF
45 pyoderma 10.3 IL1R1 TNF
46 somatoform disorder 10.3 IL1B IL1RN
47 complex regional pain syndrome 10.3 IL1B TNF
48 rheumatic fever 10.3 MBL2 TNF
49 chikungunya 10.3 IL1B TNF
50 keratoconjunctivitis sicca 10.3 IL1B TNF

Graphical network of the top 20 diseases related to Vulvar Vestibulitis Syndrome:



Diseases related to Vulvar Vestibulitis Syndrome

Symptoms & Phenotypes for Vulvar Vestibulitis Syndrome

MGI Mouse Phenotypes related to Vulvar Vestibulitis Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 ESR1 IL1B IL1R1 IL1RN MBL2 MC1R
2 growth/size/body region MP:0005378 9.95 ESR1 IL1B IL1R1 IL1RN MC1R NLRP3
3 homeostasis/metabolism MP:0005376 9.87 ESR1 IL1B IL1R1 IL1RN MBL2 NLRP3
4 immune system MP:0005387 9.86 ESR1 IL1B IL1R1 IL1RN MBL2 MC1R
5 integument MP:0010771 9.7 MC1R NLRP3 TNF ESR1 IL1B IL1R1
6 neoplasm MP:0002006 9.35 ESR1 IL1B IL1R1 MC1R TNF
7 skeleton MP:0005390 9.1 TNF ESR1 IL1B IL1R1 IL1RN NLRP3

Drugs & Therapeutics for Vulvar Vestibulitis Syndrome

Drugs for Vulvar Vestibulitis Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 3,Phase 2 51-84-3 187
2
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 137-58-6 3676
3 abobotulinumtoxinA Phase 4,Phase 3
4 Cholinergic Agents Phase 4,Phase 3,Phase 2
5 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
6 onabotulinumtoxinA Phase 4,Phase 3
7 Botulinum Toxins, Type A Phase 4,Phase 3
8 Botulinum Toxins Phase 4,Phase 3,Phase 2
9 Central Nervous System Depressants Phase 4,Phase 2,Phase 1,Not Applicable
10 Sodium Channel Blockers Phase 4,Phase 2,Phase 1,Not Applicable
11 Anesthetics Phase 4,Phase 2,Phase 1,Not Applicable
12 Anesthetics, Local Phase 4,Phase 2,Phase 1,Not Applicable
13 Diuretics, Potassium Sparing Phase 4,Phase 2,Phase 1,Not Applicable
14 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 1,Not Applicable
15 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
16
Nifedipine Approved Phase 3 21829-25-4 4485
17
Capsaicin Approved Phase 2, Phase 3,Phase 1 404-86-4 1548943
18
Milnacipran Approved, Investigational Phase 3 92623-85-3 65833
19 Tomato Approved, Nutraceutical Phase 3
20 calcium channel blockers Phase 3,Phase 2
21 Adrenergic Agents Phase 3,Not Applicable
22 Serotonin Agents Phase 3
23 Serotonin Uptake Inhibitors Phase 3
24 Neurotransmitter Uptake Inhibitors Phase 3,Not Applicable
25 Tocolytic Agents Phase 3
26 Dermatologic Agents Phase 2, Phase 3,Phase 1
27 Vasodilator Agents Phase 3
28 Antidepressive Agents Phase 3,Not Applicable
29 Antipruritics Phase 2, Phase 3,Phase 1
30 Psychotropic Drugs Phase 3,Phase 2,Not Applicable
31 Calcium, Dietary Phase 3,Phase 2
32 Neuromuscular Agents Phase 3
33 Pharmaceutical Solutions Phase 3
34
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
35
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100
36
Histamine Approved, Investigational Phase 2 75614-87-8, 51-45-6 774
37
Promethazine Approved, Investigational Phase 2 60-87-7 4927
38
Enoxaparin Approved Phase 2 9005-49-6 772
39
Pregabalin Approved, Illicit, Investigational Phase 2 148553-50-8 5486971
40
Petrolatum Approved, Investigational Phase 2 8009-03-8
41
Histamine Phosphate Phase 2 51-74-1 65513
42 Gastrointestinal Agents Phase 2
43 Histamine Antagonists Phase 2
44 Histamine H1 Antagonists Phase 2
45 Anti-Allergic Agents Phase 2
46 Hypnotics and Sedatives Phase 2,Not Applicable
47 Antiemetics Phase 2
48 Autonomic Agents Phase 2
49 Analgesics Phase 2
50 Tranquilizing Agents Phase 2

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4 Botulinum toxin
2 Study to Compare the Efficacy of Cognitive-behavioral Couple Therapy and Lidocaine for Provoked Vestibulodynia Active, not recruiting NCT01935063 Phase 4
3 Dysbiosis in Localized Provoked Vulvodynia (LPV) Unknown status NCT02393911 Phase 3
4 Savella in Treatment for Provoked Vestibulodynia Completed NCT01304589 Phase 3 Milnacipran
5 Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis Completed NCT00496184 Phase 3 Nifedipine cream topical application
6 A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia Recruiting NCT02858219 Phase 3 Botulinum Toxin Type A
7 A Study of the Effects of Topical Capsaicin in the Treatment of Provoked Vestibulodynia Recruiting NCT02854670 Phase 2, Phase 3 Capsaicin patch
8 Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia Recruiting NCT02773641 Phase 3 Botulinum Toxin Type A;Sterile Saline Solution
9 Phase I/II Randomized, Placebo-Controlled Study of Capsaicin for Interstitial Cystitis and Vulvar Vestibulitis Completed NCT00004316 Phase 1, Phase 2 capsaicin
10 Enoxaparin as Treatment for Vulvodynia Completed NCT00874484 Phase 2 Clexane (enoxaparin)
11 Infiltration of the Vestibulum Vaginae With Botulin Toxin in Patients With Localized Provoked Vulvodynia Completed NCT01747161 Phase 2 Botulin toxin;physiological water
12 Safety and Efficacy of Two Vaginal Products Versus Placebo in Patients With Vaginal Discomfort Completed NCT00590590 Phase 2 Lidocaine/Diphenhydramine;lidocaine;placebo
13 5% Lidocaine Ointment in the Treatment of Vulvar Vestibulitis Terminated NCT00450242 Phase 2 5% topical lidocaine ointment;Placebo cream
14 Pregabalin for the Treatment of Vulvodynia Terminated NCT00853229 Phase 2 pregabalin
15 Provoked, Localized Vulvodynia Treatment With Acupuncture and Lidocaine Pilot Study Completed NCT01996384 Phase 1 Lidocaine
16 Effectiveness of Cognitive Behavioural Therapy and Physical Therapy for Provoked Vestibulodynia Completed NCT02494934 Not Applicable
17 Integrated Mindfulness-based Cognitive Behaviour Therapy Versus Cognitive Behaviour Therapy for Provoked Vestibulodynia Completed NCT01704456 Not Applicable
18 Integrated Mindfulness for Provoked Vestibulodynia Completed NCT01704443 Not Applicable
19 The Use of Acupuncture for the Treatment of Vulvar Vestibulitis Completed NCT02362763 Not Applicable
20 Efficacy of a Physiotherapy Treatment in Women Suffering From Provoked Vestibulodynia Completed NCT01455350 Not Applicable lidocaine
21 Pilot Study to Assess the Efficacy of Cognitive-behavioral Couple Therapy for Provoked Vestibulodynia Completed NCT01582373 Not Applicable
22 Vulvar Vestibulitis Clinical Trial: Desipramine-Lidocaine Completed NCT00276068 Not Applicable topical lidocaine + oral desipramine, and/or placebo
23 Long-Term Assessment of Quality of Life and Effectiveness of Onabotulinumtoxina Injections in Provoked Vestibulodynia Completed NCT02858375
24 Efficacy of Transcranial Direct-Current Stimulation (tDCS) for Provoked Vestibulodynia : a Triple Blind Randomized Controlled Trial Completed NCT02543593 Not Applicable
25 "Vestibulitis Educational Seminar Trial" Study Completed NCT00278850
26 A Search for Helicobacter Pylori in Localized Vulvodynia Completed NCT00501774
27 Pregnancy, Childbirth Intentions and Outcomes Under Sexual Pain Completed NCT01731288
28 Multi Modal Imaging: An MRI Study to Investigate Differences in the Structure and the Function of the Brain at Rest. Completed NCT01517516
29 Acupuncture for the Treatment of Vulvodynia Completed NCT02197429 Not Applicable
30 Acupuncture for Vulvodynia: A Pre-pilot Study Completed NCT02704234 Not Applicable
31 Outcomes of Delivery in Patients With Dyspareunia Completed NCT01753258
32 The Effectiveness of Vestibulectomy Completed NCT00873301 Not Applicable
33 Physiotherapy Intervention for Provoked Vulvar Vestibulodynia Recruiting NCT01628679 Not Applicable
34 Lipofilling as a Treatment for Vestibulodynia Recruiting NCT03431779 Not Applicable
35 Subtypes of Provoked Vestibulodynia Recruiting NCT02712814 Topical hormonal cream (estrogen)
36 The Reciprocal Relations Between Psychosocial Characteristics and the Progression of Vestibulodynia Recruiting NCT02892214 estriol cream (ovestin)
37 Effect of Acupuncture on Patient Vulvodynia Outcomes Recruiting NCT03364127 Not Applicable
38 Effect of Two Acupuncture Protocols on Vulvodynia Recruiting NCT03481621 Not Applicable
39 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Recruiting NCT02732145
40 Innovations in the Treatment of Sexual Health Post Prostate Cancer Treatment: Comparing Mindfulness vs. CBT Recruiting NCT03365518 Not Applicable
41 Randomized Comparison of Mindfulness Versus Group Support for Treatment of Low Sexual Desire in Women Recruiting NCT01690897 Not Applicable
42 Intimacy and Mindfulness Post-Prostate Cancer Treatment Active, not recruiting NCT03177707 Not Applicable
43 Low Level Laser Therapy for the Treatment of Provoked Vestibulodynia Terminated NCT01149031 Not Applicable
44 Cold Laser: A Modality to Promote Vulvar Healing and Pain Relief Terminated NCT02204319 Not Applicable
45 Study of Emu Oil vs. Placebo for Vulvar Pain in Women. Terminated NCT01295268 Not Applicable
46 Hormonal Contraceptive Use and the Risk of Provoked Vestibulodynia Withdrawn NCT01741948 Hormonal contraceptive
47 Randomized CO2 vs Sham Laser Treatment of Provoked Vestibulodynia Withdrawn NCT03390049 Not Applicable

Search NIH Clinical Center for Vulvar Vestibulitis Syndrome

Genetic Tests for Vulvar Vestibulitis Syndrome

Anatomical Context for Vulvar Vestibulitis Syndrome

MalaCards organs/tissues related to Vulvar Vestibulitis Syndrome:

41
Prostate, Brain, Testes

Publications for Vulvar Vestibulitis Syndrome

Articles related to Vulvar Vestibulitis Syndrome:

(show top 50) (show all 82)
# Title Authors Year
1
The bacterial microbiome in paired vaginal and vestibular samples from women with vulvar vestibulitis syndrome. ( 24961922 )
2014
2
Elevated tissue levels of tumor necrosis factor-I+ in vulvar vestibulitis syndrome. ( 25551965 )
2014
3
Sacral neuromodulation in the treatment of vulvar vestibulitis syndrome. ( 19622972 )
2009
4
Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome. ( 19254587 )
2009
5
Botulinum neurotoxin type A injections for vaginismus secondary to vulvar vestibulitis syndrome. ( 20168100 )
2009
6
Overlap between orofacial pain and vulvar vestibulitis syndrome. ( 18287822 )
2008
7
Association between primary vulvar vestibulitis syndrome, defective induction of tumor necrosis factor-alpha, and carriage of the mannose-binding lectin codon 54 gene polymorphism. ( 18166320 )
2008
8
Somatization and psychological distress among women with vulvar vestibulitis syndrome. ( 18635182 )
2008
9
Multilevel local anesthetic nerve blockade for the treatment of vulvar vestibulitis syndrome. ( 17936236 )
2008
10
Vulvar vestibulitis syndrome and estrogen dose of oral contraceptive pills. ( 17970976 )
2007
11
Effectiveness of hypnosis for the treatment of vulvar vestibulitis syndrome: a preliminary investigation. ( 17367437 )
2007
12
Effects of sexual arousal on genital and non-genital sensation: a comparison of women with vulvar vestibulitis syndrome and healthy controls. ( 17136588 )
2007
13
Human papillomavirus in vulvar vestibulitis syndrome. ( 17694965 )
2007
14
Surgical treatment of vulvar vestibulitis syndrome: outcome assessment derived from a postoperative questionnaire. ( 16942537 )
2006
15
A cognitive-behavioral group program for women with vulvar vestibulitis syndrome (VVS): factors associated with treatment success. ( 16809249 )
2006
16
Vulvar vestibulitis syndrome. ( 17064641 )
2006
17
Tender point examination in women with vulvar vestibulitis syndrome. ( 16926575 )
2006
18
Surgical techniques: Surgery for Vulvar Vestibulitis syndrome. ( 16681483 )
2006
19
Surgical treatment for the vulvar vestibulitis syndrome. ( 16449109 )
2006
20
A conceptual model for the pathophysiology of vulvar vestibulitis syndrome. ( 16719941 )
2006
21
Hyperoxaluria in women with vulvar vestibulitis syndrome. ( 16846091 )
2006
22
Psychological factors associated with perception of experimental pain in vulvar vestibulitis syndrome. ( 16020147 )
2005
23
Vulvar vestibulitis syndrome: a review. ( 15927350 )
2005
24
Vulvar vestibulitis syndrome: an important factor in the evaluation of lifelong vaginismus? ( 16457419 )
2005
25
Personality traits associated with perception of noxious stimuli in women with vulvar vestibulitis syndrome. ( 15772910 )
2005
26
Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome. ( 15836975 )
2005
27
Psychological aspects of vulvar vestibulitis syndrome. ( 16050535 )
2005
28
The major histopathologic characteristics in the vulvar vestibulitis syndrome. ( 15542936 )
2005
29
Pelvic floor muscle functioning in women with vulvar vestibulitis syndrome. ( 16050536 )
2005
30
To cut or not to cut: treatment of vulvar vestibulitis syndrome. ( 15376407 )
2004
31
Impact of genetic variation in interleukin-1 receptor antagonist and melanocortin-1 receptor genes on vulvar vestibulitis syndrome. ( 15305821 )
2004
32
A new instrument for pain assessment in vulvar vestibulitis syndrome. ( 15043051 )
2004
33
Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome. ( 15467537 )
2004
34
Vulvar vestibulitis syndrome: a clinical approach. ( 15205070 )
2004
35
Capsaicin and the treatment of vulvar vestibulitis syndrome: a valuable alternative? ( 15775875 )
2004
36
Immunoglobulin E antibodies to seminal fluid in women with vulvar vestibulitis syndrome: relation to onset and timing of symptoms. ( 15041996 )
2004
37
Primary and secondary vulvar vestibulitis syndrome: systemic pain perception and psychophysical characteristics. ( 15295354 )
2004
38
Association between quantitative sensory testing, treatment choice, and subsequent pain reduction in vulvar vestibulitis syndrome. ( 15162345 )
2004
39
Estrogen receptor expression in vulvar vestibulitis syndrome. ( 14520218 )
2003
40
Hypnotherapy as a treatment for vulvar vestibulitis syndrome: a case report. ( 12851128 )
2003
41
Interleukin-1beta gene polymorphism in women with vulvar vestibulitis syndrome. ( 12593899 )
2003
42
Psychological profiles among women with vulvar vestibulitis syndrome: a chart review. ( 14584306 )
2003
43
Vestibular tactile and pain thresholds in women with vulvar vestibulitis syndrome. ( 11932072 )
2002
44
Physical therapy for vulvar vestibulitis syndrome: a retrospective study. ( 11995597 )
2002
45
Defective regulation of the proinflammatory immune response in women with vulvar vestibulitis syndrome. ( 11967493 )
2002
46
In favor of an integrated pain-relief treatment approach for vulvar vestibulitis syndrome. ( 12061041 )
2002
47
Differential characterization of women with vulvar vestibulitis syndrome. ( 12237632 )
2002
48
Web-enabled Glazer surface electromyographic protocol for the remote, real-time assessment and rehabilitation of pelvic floor dysfunction in vulvar vestibulitis syndrome. A case report. ( 12380455 )
2002
49
Vulvar vestibulitis syndrome: care made to measure. ( 12061037 )
2002
50
Vulvar vestibulitis syndrome: an overview of non-surgical treatment. ( 11858882 )
2002

Variations for Vulvar Vestibulitis Syndrome

Expression for Vulvar Vestibulitis Syndrome

Search GEO for disease gene expression data for Vulvar Vestibulitis Syndrome.

Pathways for Vulvar Vestibulitis Syndrome

Pathways related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.77 IL1B MBL2 NLRP3 TNF
2 12.36 IL1B IL1RN TNF
3
Show member pathways
12.28 ESR1 IL1B IL1RN
4
Show member pathways
12.27 IL1B IL1R1 TNF
5
Show member pathways
12.24 IL1B IL1R1 TNF
6
Show member pathways
12.09 IL1B IL1R1 IL1RN
7
Show member pathways
12.05 IL1B IL1R1 TNF
8
Show member pathways
12.03 IL1B IL1R1 TNF
9
Show member pathways
12 IL1B NLRP3 TNF
10
Show member pathways
11.99 IL1B NLRP3 TNF
11
Show member pathways
11.94 IL1B IL1R1 TNF
12 11.92 IL1B IL1RN TNF
13 11.83 IL1B IL1R1 TNF
14 11.78 IL1B IL1R1 TNF
15 11.73 IL1B IL1R1 TNF
16
Show member pathways
11.7 IL1B IL1R1 IL1RN TNF
17 11.62 IL1B IL1R1 TNF
18 11.59 IL1B IL1R1 TNF
19 11.56 IL1B IL1R1 TNF
20 11.45 IL1B IL1R1 TNF
21 11.38 IL1B NLRP3 TNF
22 11.36 IL1B TNF
23 11.35 ESR1 TNF
24 11.34 IL1B TNF
25 11.34 IL1B TNF
26 11.31 IL1B TNF
27 11.26 IL1B NLRP3
28 11.18 IL1B TNF
29 11.18 IL1B TNF
30 11.13 IL1B TNF
31 11.11 IL1B TNF
32 11.09 IL1B TNF
33
Show member pathways
11.07 IL1B IL1R1 TNF
34 10.93 IL1B TNF
35 10.73 IL1B TNF
36 10.61 IL1B IL1R1 IL1RN TNF
37 10.53 IL1B IL1R1 NLRP3

GO Terms for Vulvar Vestibulitis Syndrome

Cellular components related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 IL1B IL1R1 IL1RN MBL2 NLRP3 TNF

Biological processes related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.97 ESR1 IL1B MC1R NLRP3 TNF
2 immune response GO:0006955 9.89 IL1B IL1R1 IL1RN TNF
3 inflammatory response GO:0006954 9.84 IL1B IL1RN NLRP3 TNF
4 positive regulation of protein kinase B signaling GO:0051897 9.79 ESR1 MC1R TNF
5 cytokine-mediated signaling pathway GO:0019221 9.76 IL1B IL1R1 IL1RN TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.75 IL1B NLRP3 TNF
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.72 ESR1 IL1B TNF
8 defense response to Gram-positive bacterium GO:0050830 9.7 MBL2 NLRP3 TNF
9 interleukin-1-mediated signaling pathway GO:0070498 9.69 IL1B IL1R1 IL1RN
10 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B TNF
11 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.65 IL1B TNF
12 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.65 NLRP3 TNF
13 protein kinase B signaling GO:0043491 9.64 IL1B TNF
14 positive regulation of interferon-gamma production GO:0032729 9.64 IL1B TNF
15 positive regulation of nitric oxide biosynthetic process GO:0045429 9.63 IL1B TNF
16 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.63 IL1B TNF
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.62 IL1B TNF
18 positive regulation of interleukin-8 production GO:0032757 9.62 IL1B TNF
19 negative regulation of lipid catabolic process GO:0050995 9.61 IL1B TNF
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 IL1B TNF
21 negative regulation of growth of symbiont in host GO:0044130 9.58 MBL2 TNF
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.56 IL1B TNF
23 positive regulation of chemokine biosynthetic process GO:0045080 9.49 IL1B TNF
24 regulation of establishment of endothelial barrier GO:1903140 9.48 IL1B TNF
25 positive regulation of fever generation GO:0031622 9.43 IL1B TNF
26 fever generation GO:0001660 9.4 IL1B IL1RN
27 interleukin-1 beta production GO:0032611 9.37 IL1B NLRP3
28 positive regulation of phagocytosis GO:0050766 9.33 IL1B MBL2 TNF
29 sequestering of triglyceride GO:0030730 9.32 IL1B TNF
30 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IL1B TNF
31 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.13 IL1B NLRP3 TNF
32 regulation of inflammatory response GO:0050727 8.92 ESR1 IL1R1 NLRP3 TNF

Molecular functions related to Vulvar Vestibulitis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL1B IL1RN TNF
2 interleukin-1 receptor binding GO:0005149 8.62 IL1B IL1RN

Sources for Vulvar Vestibulitis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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