MCID: VLV010
MIFTS: 42

Vulvovaginitis

Categories: Reproductive diseases

Aliases & Classifications for Vulvovaginitis

MalaCards integrated aliases for Vulvovaginitis:

Name: Vulvovaginitis 12 75 55 44 15 17 72
Vulvo-Vaginitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2273
MeSH 44 D014848
NCIt 50 C35131
SNOMED-CT 68 53277000
ICD10 33 N76.0
UMLS 72 C0042998

Summaries for Vulvovaginitis

Disease Ontology : 12 A female reproductive system disease that is characterized by inflammation of the vagina and vulva.

MalaCards based summary : Vulvovaginitis, also known as vulvo-vaginitis, is related to cervicitis and chlamydia. An important gene associated with Vulvovaginitis is HSPD1 (Heat Shock Protein Family D (Hsp60) Member 1), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Clindamycin and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and skin.

Wikipedia : 75 Vaginitis, also known as vulvovaginitis, is inflammation of the vagina and vulva. Symptoms may include... more...

Related Diseases for Vulvovaginitis

Diseases related to Vulvovaginitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 348)
# Related Disease Score Top Affiliating Genes
1 cervicitis 31.1 HSPD1 CXCL8
2 chlamydia 30.6 IL10 HSPD1 CXCL8
3 oral lichen planus 30.4 HSPD1 CCL5
4 contact dermatitis 30.4 IL10 CXCL8
5 pyelonephritis 30.3 IL10 CXCL8
6 allergic contact dermatitis 30.3 IL10 CXCL8
7 conjunctivitis 30.3 CXCL8 CCL11
8 keratoconjunctivitis 30.2 CXCL8 CCL11
9 skin disease 30.2 IL10 CXCL8 CCL11
10 acute pyelonephritis 30.1 IL10 CXCL8
11 bacterial infectious disease 30.1 IL10 HSPD1 CXCL8
12 genital herpes 30.1 IL10 CCL5
13 allergic hypersensitivity disease 30.0 IL10 CCL5 CCL11
14 rhinitis 29.9 CXCL8 CCL5 CCL11
15 mastitis 29.8 CXCL8 CCL5
16 toxic shock syndrome 29.8 IL10 CXCL8
17 allergic rhinitis 29.6 IL10 CXCL8 CCL11
18 pulmonary disease, chronic obstructive 29.4 CXCL8 CCL5 CCL11
19 peritonitis 29.3 IL10 CXCL8
20 human immunodeficiency virus type 1 29.3 IL10 CCL5 CCL11
21 dermatitis, atopic 28.7 IL10 CXCL8 CCL5 CCL11
22 vulvovaginal candidiasis 12.8
23 vulvovaginal gingival syndrome 12.4
24 vulvovaginal rhabdomyosarcoma 12.3
25 vulvovaginitis, allergic seminal 12.3
26 rare vulvovaginal tumor 12.2
27 rare non-malformative uterovaginal or vulvovaginal disease 12.2
28 obsolete: hiv-related vulvovaginal cancer 12.2
29 vaginitis 11.8
30 vulvar disease 11.7
31 vulvitis 11.6
32 vulvar vestibulitis syndrome 11.6
33 candidiasis 11.2
34 vaginal discharge 10.8
35 bacterial vaginosis 10.7
36 candida glabrata 10.7
37 lichen planus 10.6
38 trichomoniasis 10.5
39 mycobacterium fortuitum 10.5 HSPD1 CXCL8
40 vaginal cancer 10.4
41 carrion's disease 10.4 HSPD1 CCL11
42 papillary conjunctivitis 10.4 CXCL8 CCL11
43 giant papillary conjunctivitis 10.4 CXCL8 CCL11
44 autoimmune atherosclerosis 10.4 IL10 HSPD1
45 postmenopausal atrophic vaginitis 10.4
46 trachoma 10.4 IL10 HSPD1
47 lichen sclerosus 10.3
48 ulceration of vulva 10.3
49 tungiasis 10.3 IL10 CXCL8
50 acute transverse myelitis 10.3 IL10 CXCL8

Graphical network of the top 20 diseases related to Vulvovaginitis:



Diseases related to Vulvovaginitis

Symptoms & Phenotypes for Vulvovaginitis

Drugs & Therapeutics for Vulvovaginitis

Drugs for Vulvovaginitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
2
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Tinidazole Approved, Investigational Phase 4 19387-91-8 5479
5 Clindamycin palmitate Phase 4
6 Clindamycin phosphate Phase 4
7 Antitubercular Agents Phase 4
8 Antibiotics, Antitubercular Phase 4
9
Butoconazole Approved Phase 3 64872-77-1, 64872-76-0 47472
10
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
11
Ketoconazole Approved, Investigational Phase 3 65277-42-1 47576
12
Terconazole Approved Phase 3 67915-31-5 441383
13
acetic acid Approved Phase 3 64-19-7 176
14 Antifungal Agents Phase 3
15 14-alpha Demethylase Inhibitors Phase 3
16 Steroid Synthesis Inhibitors Phase 3
17 Cytochrome P-450 Enzyme Inhibitors Phase 3
18 Hormone Antagonists Phase 3
19 Hormones Phase 3
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
21 Cytochrome P-450 CYP3A Inhibitors Phase 3
22 Anti-Bacterial Agents Phase 3
23 Anti-Infective Agents Phase 3
24
Retinol acetate Phase 3 127-47-9 10245972
25 Albaconazole Investigational Phase 2 187949-02-6
26 Pharmaceutical Solutions Phase 2
27 Estrogens
28 Acidophilus

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Multicenter Pilot Study to Compare the Efficacy of a Combination of Vaginal Capsules With Acid Boric, L.Gasseri and L.Rhamnosus Versus the Reference Medication in Patients With Vaginal Candidiasis or Bacterial Vaginosis Completed NCT02860845 Phase 4 Antibiotic (Clindamycin);Antifungal (Clotrimazole)
2 A National, Multi-central, Open-label, Single-arm, Phase IV Study to Evaluate Efficacy and Safety of Gynomax® XL Ovule in the Treatment of Trichomonal Vaginitis, Bacterial Vaginosis, Candidal Vulvovaginitis and Mixed Vaginal Infections Recruiting NCT03839875 Phase 4 Gynomax® XL Vaginal Ovule
3 Vaginal Infection Study Completed NCT00616330 Phase 3 clindamycin phosphate/butoconazole nitrate;clindamycin phosphate;butoconazole nitrate
4 Randomized Clinical Trial for Treatment of Candidal Vulvovaginitis Using Cumin Seed Extract Vaginal Cream. Recruiting NCT03005353 Phase 2, Phase 3 Cumin seed extract;clotrimazole
5 A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) vs. Placebo in Subjects With Acute Vulvovaginal Candidiasis Recruiting NCT03734991 Phase 3 Ibrexafungerp;Placebo
6 A Phase 3, Multicenter, Randomized, Double-Blind, Placebo Controlled Study to Evaluate the Efficacy and Safety of Oral Ibrexafungerp (SCY-078) vs. Placebo in Subjects With Acute Vulvovaginal Candidiasis (AVVC). Recruiting NCT03987620 Phase 3 Ibrexafungerp;Placebo
7 Ketoconazole In Situ Gel Versus Terconazole Cream for Treatment of Vaginal Candidiasis Not yet recruiting NCT03473418 Phase 3 Ketoconazole;Terconazole
8 Safety and Efficacy of Two Screen-and-Treat Approaches for the Prevention of Cervical Cancer Terminated NCT00233727 Phase 3
9 A Multi-Center Randomized Study to Evaluate the Safety, Tolerability, and Efficacy of Oral Encochleated Amphotericin B (CAMB/MAT2203) Compared With Oral Fluconazole in the Treatment of Moderate to Severe Vulvovaginal Candidiasis (VVC) Completed NCT02971007 Phase 2 Oral Encochleated Amphotericin B (CAMB);Fluconazole
10 A Phase 2, Multicenter, Randomized, Double-Blind, Double-Dummy, Active-Controlled, Dose-Finding Study to Compare the Safety and Efficacy of Oral Ibrexafungerp (SCY-078) vs. Oral Fluconazole in Subjects With Acute Vulvovaginal Candidiasis Completed NCT03253094 Phase 2 Fluconazole;SCY-078
11 A Single-Blind, Randomized, Dose-Finding Study Versus Fluconazole to Assess the Efficacy and Tolerability of Five Single Doses of Albaconazole in the Treatment of Acute Non-Recurrent Candida Spp Vulvovaginitis Terminated NCT00199264 Phase 2 Albaconazole oral solution
12 A Single-Center, Open-Label, Pilot Study to Evaluate the Efficacy and Safety of Oral Encochleated Amphotericin B (CAMB) in the Treatment of Fluconazole-Resistant Vulvovaginal Candidiasis Withdrawn NCT03167957 Phase 2 Oral Encochleated Amphotericin B (CAMB);Oral Encochleated Amphotericin B (CAMB)
13 Maternal and Perinatal Outcome in Women With History of Premature Labor in Previous Pregnancy and Submitted to Active Search of Genital Infection Completed NCT01375439
14 Comparing NAAT Testing to Standard Methods in Diagnosis of Vaginal Infections in the General Gynecology and Vulvovaginal Referral Offices. Completed NCT02203942
15 Vaginal Cytokines in Postmenopausal Women With Symptoms of Vulvovaginal Irritation Completed NCT01899612
16 Fractional / Pixel CO2 Laser Treatment of Vulvar Atrophy and Lichen Sclerosus Completed NCT03063684
17 An Open-label Study to Evaluate Clinical Performance of Gedea Pessary in Adult Women With Vulvovaginal Candidiasis Recruiting NCT03761628
18 An Open-label Study to Evaluate Clinical Performance of Gedea Pessary in Adult Women With Bacterial Vaginosis Recruiting NCT03762083
19 Gynaecological Disorders in Patients With Not-celiac Wheat Sensitivity Recruiting NCT03027492
20 Evaluation of Performance and Safety of the CE Marked Medical Device Class IIb Celegyn® in Vulvovaginal Atrophy (VVA): a Randomised, Double-blind, Parallel Groups, Multicentric, Placebo-Controlled, Prospective Clinical Study Not yet recruiting NCT03823560
21 Prevention of Recurrent Vulvovaginal Candidiasis With Lactibiane Candisis 5M® Terminated NCT00915629

Search NIH Clinical Center for Vulvovaginitis

Cochrane evidence based reviews: vulvovaginitis

Genetic Tests for Vulvovaginitis

Anatomical Context for Vulvovaginitis

MalaCards organs/tissues related to Vulvovaginitis:

41
Testes, Colon, Skin, Kidney, Bone, Bone Marrow, Lymph Node

Publications for Vulvovaginitis

Articles related to Vulvovaginitis:

(show top 50) (show all 1125)
# Title Authors PMID Year
1
Detection of the human 70-kD and 60-kD heat shock proteins in the vagina: relation to microbial flora, vaginal pH, and method of contraception. 9 38
10231004 1999
2
Association of Ureaplasma diversum with reproductive disease in cattle. 38
31131738 2019
3
Estimated burden of fungal infections in Sweden. 38
31376228 2019
4
Dermatomyositis Presenting as Vulvovaginitis. 38
31306316 2019
5
Use of Dapagliflozin in the Management of Type 2 Diabetes Mellitus: A Real-World Evidence Study in Indian Patients (FOREFRONT). 38
31339784 2019
6
A pilot study of soft gel technology: a new vaginal device to improve the symptomatology of vulvovaginal atrophy in post-partum, menopause and in patients with recurrent vulvovaginitis. 38
31364105 2019
7
Transcriptomic Analysis of Streptococcus pyogenes Colonizing the Vaginal Mucosa Identifies hupY, an MtsR-Regulated Adhesin Involved in Heme Utilization. 38
31239377 2019
8
Recurrent vulvo-vaginal candidiasis in Abidjan (Côte d'Ivoire): Aetiology and associated factors. 38
31010729 2019
9
Acceptability, tolerability, and effects on symptoms and signs of vulvovaginitis of a non-soap, herbal-based intimate hygiene solution (Zelesse®). 38
31088247 2019
10
A Novel 1,3-Beta-d-Glucan Inhibitor, Ibrexafungerp (Formerly SCY-078), Shows Potent Activity in the Lower pH Environment of Vulvovaginitis. 38
30885896 2019
11
Streptococcal toxic shock syndrome following group A streptococcal vulvovaginitis in a breastfeeding woman. 38
31151810 2019
12
Sexual violence: epidemiological and clinical aspects and circumstances of occurrence among women seen at the Gynecology-Obstetrics department of the Ignace Deen National Hospital of Conakry University Hospital. 38
31379348 2019
13
Vulvovaginal Discomfort Is Common in Both Premenopausal and Postmenopausal Women. 38
30741753 2019
14
Ultraviolet A/blue light-emitting diode therapy for vulvovaginal candidiasis: a case presentation. 38
30945022 2019
15
Amebic Infection of the Female Genital Tract: A Report of Three Cases. 38
31391760 2019
16
Impact of the Sampling Site in the Result of Wet Mount Microscopy. 38
30907778 2019
17
Alternative and complementary therapies for vulvovaginal candidiasis. 38
30269301 2019
18
Candida glabrata Fungemia Following Robotic Total Laparoscopic Hysterectomy and Bilateral Salpingo-oophorectomy in a Patient with Recurrent Vulvovaginitis: A Case Report. 38
31187014 2019
19
50 Years Ago in The Journal of Pediatrics: Vulvovaginitis in the Premenarcheal Child. 38
30798826 2019
20
Biofilms and vulvovaginal candidiasis. 38
30447520 2019
21
In Vivo Applicability of Neosartorya fischeri Antifungal Protein 2 (NFAP2) in Treatment of Vulvovaginal Candidiasis. 38
30478163 2019
22
Comparative risk of genital infections associated with sodium-glucose co-transporter-2 inhibitors. 38
30207042 2019
23
Erosive Vulvovaginitis Associated With Borrelia burgdorferi Infection. 38
31043089 2019
24
Chronic vulvovaginitis caused by Candida dubliniensis in an immunologically competent adult female. 38
30170531 2019
25
Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its Many Disguises. 38
31096219 2019
26
Health care utilization and costs following amplified versus non-amplified molecular probe testing for symptomatic patients with suspected vulvovaginitis: a US commercial payer population. 38
30863131 2019
27
Disorders of vulva and vagina in children and adolescent. 38
30650979 2018
28
Intravaginal boric acid: is it an alternative therapeutic option for vaginal trichomoniasis? 38
29223972 2018
29
Sexual behaviour and extra-genital colonisation in women treated for recurrent Candida vulvo-vaginitis. 38
29998617 2018
30
Is multiple-site colonization with Candida spp. related to inadequate response to individualized fluconazole maintenance therapy in women with recurrent Candida vulvovaginitis? 38
30293562 2018
31
[Occult foreign body: A rare cause of recurrent vulvovaginitis]. 38
30482451 2018
32
An Update on the Roles of Non-albicansCandida Species in Vulvovaginitis. 38
30384449 2018
33
Prevalence and antifungal susceptibility of Candida species among pregnant women attending a school maternity at Natal, Brazil. 38
29908032 2018
34
The Relationship Between Vulvovaginal Candidiasis and Provoked Vulvodynia: A Systematic Review. 38
30145093 2018
35
Vulval lichen planus-lichen sclerosus overlap. 38
29490571 2018
36
Efficacy, acceptability and tolerability of Zelesse® for the treatment of non-specific vulvovaginitis in paediatric patients: The NINESSE Study. 38
29877120 2018
37
Molecular characterization and virulence of an alphaherpesvirus isolated from a BoHV1 gB-seropositive and gE-seronegative Italian buffalo. 38
29981704 2018
38
Spontaneous resolution of labial adhesions in pre-pubertal girls. 38
29436045 2018
39
Prepubertal vulvovaginitis. 38
29970369 2018
40
National surveillance plan for infectious bovine rhinotracheitis (IBR) in autochthonous Italian cattle breeds: Results of first year of activity. 38
29778188 2018
41
Psoriasin, a novel anti-Candida albicans adhesin. 38
29736603 2018
42
Parapoxviral vulvovaginitis in Holstein cows. 38
29429402 2018
43
Vulvovaginitis- presentation of more common problems in pediatric and adolescent gynecology. 38
28927766 2018
44
Nerve Growth Factor and Selected Cytokines in Women With and Without Vulvodynia. 38
29570566 2018
45
Effect of 2-Phenylethanol as Antifungal Agent and Common Antifungals (Amphotericin B, Fluconazole, and Itraconazole) on Candida Species Isolated from Chronic and Recurrent Cases of Candidal Vulvovaginitis. 38
29658789 2018
46
Differentiation of bovine herpesvirus1 subtypes based on UL0.5 gene sequencing. 38
29607367 2018
47
An unusual presentation of pseudocowpox associated with an outbreak of pustular ulcerative vulvovaginitis in a Swedish dairy herd. 38
29153035 2018
48
First report of Vulvovaginitis due to Cryptococcus magnus in Iran. 38
30186991 2018
49
Bovine herpesvirus-1 in three major milk sheds of Ethiopia: Serostatus and association with reproductive disorders in dairy cattle. 38
29406079 2018
50
Pediatric Resident Training in Prepubertal Vulvar Conditions. 38
28919147 2018

Variations for Vulvovaginitis

Expression for Vulvovaginitis

Search GEO for disease gene expression data for Vulvovaginitis.

Pathways for Vulvovaginitis

Pathways related to Vulvovaginitis according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.95 IL10 CXCL8 CCL5 CCL11
2
Show member pathways
12.52 IL10 HSPD1 CXCL8 CCL11
3
Show member pathways
12.03 CXCL8 CCL5 CCL11
4
Show member pathways
11.91 CXCL8 CCL5 CCL11
5 11.84 IL10 HSPD1 CXCL8
6
Show member pathways
11.64 IL10 CXCL8 CCL5 CCL11
7 11.6 IL10 CXCL8 CCL11
8 11.47 IL10 CXCL8
9 11.38 IL10 CCL11
10 11.32 HSPD1 CXCL8
11 11.28 IL10 CCL5 CCL11
12 11.25 IL10 CXCL8
13 11.22 CXCL8 CCL11
14 11.2 IL10 CCL11
15 11.18 IL10 HSPD1
16 11.13 CXCL8 CCL5 CCL11
17 10.87 CXCL8 CCL5
18 10.82 IL10 CXCL8 CCL5
19 10.64 IL10 CXCL8 CCL5 CCL11
20 10.15 IL10 CXCL8 CCL5 CCL11

GO Terms for Vulvovaginitis

Cellular components related to Vulvovaginitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 IL10 HSPD1 CXCL8 CCL5 CCL11

Biological processes related to Vulvovaginitis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.67 CXCL8 CCL5 CCL11
2 inflammatory response GO:0006954 9.67 IL10 CXCL8 CCL5 CCL11
3 cellular response to tumor necrosis factor GO:0071356 9.61 CXCL8 CCL5 CCL11
4 positive regulation of endothelial cell proliferation GO:0001938 9.6 IL10 CCL11
5 monocyte chemotaxis GO:0002548 9.58 CCL5 CCL11
6 lymphocyte chemotaxis GO:0048247 9.57 CCL5 CCL11
7 B cell proliferation GO:0042100 9.56 IL10 HSPD1
8 cellular response to fibroblast growth factor stimulus GO:0044344 9.55 CXCL8 CCL5
9 leukocyte chemotaxis GO:0030595 9.54 IL10 CXCL8
10 eosinophil chemotaxis GO:0048245 9.52 CCL5 CCL11
11 positive regulation of macrophage activation GO:0043032 9.51 IL10 HSPD1
12 neutrophil chemotaxis GO:0030593 9.5 CXCL8 CCL5 CCL11
13 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.48 CXCL8 CCL5
14 response to molecule of bacterial origin GO:0002237 9.46 IL10 CXCL8
15 cellular response to interleukin-1 GO:0071347 9.43 CXCL8 CCL5 CCL11
16 neutrophil activation GO:0042119 9.4 CXCL8 CCL5
17 chemokine-mediated signaling pathway GO:0070098 9.33 CXCL8 CCL5 CCL11
18 response to glucocorticoid GO:0051384 9.29 IL10
19 response to activity GO:0014823 9.28 IL10
20 cytokine-mediated signaling pathway GO:0019221 9.26 IL10 CXCL8 CCL5 CCL11
21 immune response GO:0006955 9.02 LST1 IL10 CXCL8 CCL5 CCL11

Molecular functions related to Vulvovaginitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CCR chemokine receptor binding GO:0048020 9.16 CCL5 CCL11
2 chemokine activity GO:0008009 9.13 CXCL8 CCL5 CCL11
3 cytokine activity GO:0005125 8.92 IL10 CXCL8 CCL5 CCL11

Sources for Vulvovaginitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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