Waldenstroem's Macroglobulinemia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Waldenstroem's Macroglobulinemia

MalaCards integrated aliases for Waldenstroem's Macroglobulinemia:

Name: Waldenstroem's Macroglobulinemia ¹² ¹⁵

Lymphoplasmacytic Lymphoma with Igm Gammopathy ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Blood diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Malignant immunoproliferative diseases

Waldenstr�m macroglobulinaemia

External Ids:

Disease Ontology ¹² DOID:0060901

ICD10 ³³ C88.0

ICD9CM ³⁵ 273.3

MeSH ⁴⁴ D008258

NCIt ⁵⁰ C80307

SNOMED-CT ⁶⁸ 35562000

UMLS ⁷³ C0024419

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Summaries for Waldenstroem's Macroglobulinemia

Disease Ontology : ¹² A lymphoplasmacytic lymphoma characterized by the accumulation of monoclonal cells in the bone marrow and peripheral lymphoid tissues, and associated with the production of serum immunoglobulin M (IgM) monoclonal protein.

MalaCards based summary : Waldenstroem's Macroglobulinemia, also known as lymphoplasmacytic lymphoma with igm gammopathy, is related to isolated growth hormone deficiency type iii and mononeuritis multiplex. An important gene associated with Waldenstroem's Macroglobulinemia is MYD88 (MYD88, Innate Immune Signal Transduction Adaptor), and among its related pathways/superpathways are Antigen processing-Cross presentation and Epstein-Barr virus infection. The drugs leucovorin and Bortezomib have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and lung, and related phenotypes are hematopoietic system and cellular

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Related Diseases for Waldenstroem's Macroglobulinemia

Diseases related to Waldenstroem's Macroglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)

#	Related Disease	Score	Top Affiliating Genes
1	isolated growth hormone deficiency type iii	10.2	BTK KMT2D
2	mononeuritis multiplex	10.2	MAG MYOM2
3	mononeuritis of upper limb and mononeuritis multiplex	10.2	MAG MYOM2
4	chronic polyneuropathy	10.2	MAG MYOM2
5	osteosclerotic myeloma	10.1	MAG MYOM2
6	irak4 deficiency	10.1	BTK MYD88
7	myd88 deficiency	10.1	BTK MYD88
8	pleuropneumonia	10.1	CD19 MYD88
9	ecthyma	10.1	BTK MYOM2
10	congenital hypogammaglobulinemia	10.1	BTK CD19
11	bladder lymphoma	10.1	CD19 CD5
12	colon lymphoma	10.1	CD19 CD5
13	invasive malignant thymoma	10.1	CD19 CD38
14	marginal zone b-cell lymphoma	10.0	CD5 KMT2D MYD88
15	cll/sll	10.0	CD38 CD5
16	diffuse large b-cell lymphoma	10.0	CD5 KMT2D MYD88
17	richter's syndrome	10.0	CD38 CD5
18	lung lymphoma	10.0	CD19 CD5
19	diffuse infiltrative lymphocytosis syndrome	10.0	CD19 CD38
20	indolent myeloma	10.0	B2M MYOM2
21	extramedullary plasmacytoma	10.0	B2M MYOM2
22	lymphatic system cancer	10.0	CD19 CD5
23	transient hypogammaglobulinemia of infancy	10.0	BTK CD19
24	amyloid tumor	10.0	B2M MYOM2
25	b cell deficiency	10.0	BTK CD19 KMT2D
26	polyradiculoneuropathy	10.0	CXCR4 MAG
27	macroglobulinemia	10.0	BTK CXCR4 MYD88
28	intravascular large b-cell lymphoma	10.0	B2M CD5
29	plasmacytoma	10.0	B2M CD38
30	lymphoma, hodgkin, classic	10.0	CD19 CD5
31	gamma heavy chain disease	10.0	CD19 CD38 MYD88
32	mantle cell lymphoma	9.9	BTK CD19 CD5
33	b cell prolymphocytic leukemia	9.9	CD19 CD38 CD5
34	small intestine lymphoma	9.9	B2M CD19
35	prolymphocytic leukemia	9.9	CD19 CD38 CD5
36	aids dementia complex	9.9	B2M CXCR4
37	common variable immunodeficiency	9.9	BTK CD19 CD38
38	immune deficiency disease	9.8	BTK CD19
39	lymphocytic leukemia	9.8	BTK CD38 CD5 MYD88
40	waldenstrom macroglobulinemia	9.8	BTK CXCR4 MAG MYD88
41	bone marrow cancer	9.8	B2M CD38 MYOM2
42	anterior scleritis	9.8	B2M CD19 CD5
43	b-cell expansion with nfkb and t-cell anergy	9.8	B2M CD38 CD5
44	human immunodeficiency virus infectious disease	9.7	B2M CD38 CXCR4
45	non-secretory myeloma	9.6	B2M CD19 CD38 MYOM2
46	solitary osseous plasmacytoma	9.6	B2M CD19 CD38 MYOM2
47	leukemia, acute myeloid	9.6	CD19 CD38 CXCR4
48	human immunodeficiency virus type 1	9.6	B2M CD38 CXCR4
49	hematologic cancer	9.5	CD19 CD38 CD5 CXCR4 KMT2D
50	plasma cell neoplasm	9.5	B2M CD19 CD38 MAG MYOM2

Graphical network of the top 20 diseases related to Waldenstroem's Macroglobulinemia:

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Symptoms & Phenotypes for Waldenstroem's Macroglobulinemia

MGI Mouse Phenotypes related to Waldenstroem's Macroglobulinemia:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.97	B2M BTK CD19 CD38 CD5 CXCR4
2	cellular	MP:0005384	9.95	B2M BTK CD19 CD38 CXCR4 KMT2D
3	homeostasis/metabolism	MP:0005376	9.86	B2M BTK CD19 CD38 CXCR4 KMT2D
4	immune system	MP:0005387	9.81	B2M BTK CD19 CD38 CD5 CXCR4
5	digestive/alimentary	MP:0005381	9.77	B2M BTK CD19 CXCR4 MYD88
6	neoplasm	MP:0002006	9.43	B2M BTK CD19 CXCR4 KMT2D MYD88
7	nervous system	MP:0003631	9.17	B2M CD19 CD5 CXCR4 KMT2D MAG

Sources

Drugs & Therapeutics for Waldenstroem's Macroglobulinemia

Drugs for Waldenstroem's Macroglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

leucovorin

Approved

Phase 1

58-05-9

6006 143

Synonyms:

(5-formyl-5,6,7,8-tetrahydropteroyl)glutamate

(6R,S)-5-Formyltetrahydrofolate

10-Formyl-7,8-dihydrofolate

10-Formyl-7,8-dihydrofolic acid

5 Formyltetrahydrofolate

5 Formyltetrahydropteroylglutamate

5-Formyl-5,6,7,8-tetrahydrofolate

5-Formyl-5,6,7,8-tetrahydrofolic acid

5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid

5-Formyltetrahydrofolate

5-formyltetrahydrofolic acid

5-Formyltetrahydrofolic acid

5-Formyltetrahydropteroylglutamate

5-Formyltetrahydropteroylglutamic acid

Acid, folinic

Acide folinique

Calcium citrovorum factor

Calcium folinate

Calcium leucovorin

Citrovorum factor

Factor, citrovorum

folinate

Folinate

Folinate, calcium

Folinic acid

Folinic acid calcium salt

Folinic acid calcium salt USP27

Folinic acid SF

Folinic acid-SF

L(-)-5-Formyl-5,6,7,8-tetrahydrofolate

L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid

Leucal

Leucovorin

Leucovorin calcium

Leucovorin folinic acid

Leucovorin, (D)-isomer

Leucovorin, (DL)-isomer

Leucovorin, (R)-isomer

Leucovorin, calcium

Leucovorin, calcium (1:1) salt

Leucovorin, calcium (1:1) salt, (DL)-isomer

Leucovorin, calcium (1:1) salt, pentahydrate

Leucovorin, monosodium salt

Leucovorinum

Leukovorin

Leukovorum

Levoleucovorin

L-leucovorin

L-Leucovorin

L-N-[P-[[(2-amino-5-Formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-glutamic acid

Monosodium salt leucovorin

N(5)-Formyltetrahydrofolate

N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid

N5-Formyl-5,6,7,8-tetrahydrofolate

N5-Formyl-5,6,7,8-tetrahydrofolic acid

N5-Formyltetrahydrofolate

N5-Formyltetrahydrofolic acid

Rescuvolin

Welcovorin

Wellcovorin

2

Bortezomib

Approved, Investigational

Phase 1

179324-69-7

387447 93860

Synonyms:

[(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid

[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid

179324-69-7

341, PS

AC1L8TUW

bortezomib

Bortezomib

Bortezomib (JAN/USAN/INN)

CHEBI:287372

CHEBI:41143

CHEMBL325041

CID387447

D03150

DB07475

DPBA

FT-0082488

I14-3268

LDP 341

LDP341

LDP-341

LPD 341

LPD-341

MLN341

MolPort-003-845-298

N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide

N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE

NCI60_029010

NSC681239

NSC-681239

PROSCRIPT BORONIC ACID

PS 341

PS-341

Pyz-Phe-boroLeu

S1013_Selleck

SBB071337

Velcade

Velcade (TN)

Velcade, MG-341, PS-341, Bortezomib

3

Folic Acid

Approved, Nutraceutical, Vet_approved

Phase 1

59-30-3

6037

Synonyms:

(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

01769_FLUKA

2d0k

33609-88-0

36653-55-1 (mono-potassium salt)

59-30-3

6484-89-5 (mono-hydrochloride salt)

AC-11682

AC1L1LNX

Acfol (Spain)

Acide folique

Acide folique [INN-French]

Acido folico

Acido folico [INN-Spanish]

Acidum folicum

Acidum folicum [INN-Latin]

Acifolic

AI3-26387

AKOS000503224

Antianemia factor

Apo-Folic

ARONIS014410

b9, Vitamin

BIDD:ER0563

BIDD:GT0641

BIF0608

bmse000299

BPBio1_000654

BSPBio_000594

BSPBio_002338

C00504

C20H20N6O6

CAS-59-30-3

CCRIS 666

CHEBI:27470

CHEMBL1622

CID6037

CPD000471860

Cytofol

D00070

DB00158

DivK1c_000494

Dosfolat b activ

Dosfolat B activ

EINECS 200-419-0

F0043

F7876_SIAL

F7876_SIGMA

F8758_SIGMA

F8798_SIAL

F8890_SIGMA

Facid

Factor U

FOL

Folacid

Folacin

Folaemin

Folaemin [Netherlands]

Folan

Folasic (Australia)

Folate

Folbal

Folcidin

Folcidin (VAN)

Folcysteine

Foldine

Foldine [France]

Folettes

Foliamin

Folic

folic acid

Folic acid (JP15/USP/INN)

Folic acid (TN)

Folic acid [BAN:INN:JAN]

Folic acid [INN:BAN:JAN]

Folic acid dihydrate

Folic acid, (D)-isomer

Folic acid, (DL)-isomer

Folic acid, calcium salt (1:1)

Folic acid, monopotassium salt

Folic acid, monosodium salt

Folic acid, potassium salt

Folic acid, sodium salt

Folicet

Folicet (TN)

Folico

Folico (Italy)

Folina

Folina (Italy)

Folipac

Folsaeure

Folsan

Folsaure

Folsäure

Folsav

Folvite

Folvron

Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L

HMS1921D20

HMS2092N17

HMS501I16

HSDB 2002

IDI1_000494

Incafolic

InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s

KBio1_000494

KBio2_001861

KBio2_004429

KBio2_006997

KBio3_001558

KBioGR_002222

KBioSS_001861

Kyselina listova

Kyselina listova [Czech]

Liver lactobacillus casei factor

Liver Lactobacillus casei factor

LS-2157

Millafol

Mission prenatal

Mittafol

MLS001304016

MLS001335861

MolPort-004-285-551

N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid

N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid

N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid

N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid

N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid

N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamate

N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid

N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-Pteridinyl)methyl]amino]benzoyl]-L-glutamic acid

NCGC00016265-01

NCGC00142391-01

nchembio.108-comp10

Nifolin

Nifolin [Denmark]

NINDS_000494

Novofolacid

Novofolacid [Canada]

N-Pteroyl-L-glutamate

N-pteroyl-L-glutamic acid

N-Pteroyl-L-glutamic acid

NSC 3073

PGA

PGA (VAN)

Prestwick_230

Prestwick3_000627

PteGlu

Pteroylglutamate

Pteroylglutamic acid

Pteroyl-L-glutamate

Pteroyl-L-glutamic acid

Pteroyl-L-monoglutamate

Pteroyl-L-monoglutamic acid

Pteroylmonoglutamate

Pteroylmonoglutamic acid

SAM002264616

SDCCGMLS-0066738.P001

Serum Folate Level

SMP2_000137

SMR000471860

SPBio_001357

Spectrum_001381

SPECTRUM1502020

Spectrum2_001459

Spectrum3_000749

Spectrum4_001751

Spectrum5_000602

UNII-935E97BOY8

Usaf cb-13

Vitamin B11

Vitamin b9

Vitamin B9

Vitamin Bc

Vitamin BC

Vitamin be

Vitamin Be

Vitamin m

Vitamin M

4

Vitamin B9

Phase 1

5

Folic Acid Antagonists

Phase 1

6

Folate

Phase 1

7

Vitamin B Complex

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase I Bortezomib (VELCADE) in Combo With Pralatrexate in Relapsed/Refractory MM	Completed	NCT01114282	Phase 1	velcade;Pralatrexate

Search NIH Clinical Center for Waldenstroem's Macroglobulinemia

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Genetic Tests for Waldenstroem's Macroglobulinemia

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Anatomical Context for Waldenstroem's Macroglobulinemia

MalaCards organs/tissues related to Waldenstroem's Macroglobulinemia:

⁴¹

Bone, Bone Marrow, Lung, Colon, B Cells, Myeloid, Small Intestine

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Publications for Waldenstroem's Macroglobulinemia

Articles related to Waldenstroem's Macroglobulinemia:

#	Title	Authors	Year
1	Cryptococcal pleural effusion in an HTLV-I carrier with Waldenstroem's macroglobulinemia. ( 1561905 )	Taguchi H....Miyoshi I.	1992
2	WALDENSTROEM'S MACROGLOBULINEMIA WITH TRANSIENT CHOLESTATIC JAUNDICE; CASE REPORT. ( 14273609 )		1965
3	CLINICAL ASPECTS OF WALDENSTROEM'S MACROGLOBULINEMIA. WITH REPORT OF A CASE. ( 14098291 )		1963

Sources

Genes for Waldenstroem's Macroglobulinemia

Genes related to Waldenstroem's Macroglobulinemia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYD88	MYD88, Innate Immune Signal Transduction Adaptor	Protein Coding	25.62	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders (show sections)
2	KMT2D	Lysine Methyltransferase 2D	Protein Coding	16.53	DISEASES inferred ¹⁵ ¹⁵
3	MYOM2	Myomesin 2	Protein Coding	16.39	DISEASES inferred ¹⁵
4	MAG	Myelin Associated Glycoprotein	Protein Coding	16.17	DISEASES inferred ¹⁵
5	BTK	Bruton Tyrosine Kinase	Protein Coding	16.16	DISEASES inferred ¹⁵
6	CD5	CD5 Molecule	Protein Coding	15.45	DISEASES inferred ¹⁵
7	CD19	CD19 Molecule	Protein Coding	15.41	DISEASES inferred ¹⁵
8	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	15.12	DISEASES inferred ¹⁵
9	B2M	Beta-2-Microglobulin	Protein Coding	15.09	DISEASES inferred ¹⁵
10	CD38	CD38 Molecule	Protein Coding	15.09	DISEASES inferred ¹⁵

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Variations for Waldenstroem's Macroglobulinemia

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Expression for Waldenstroem's Macroglobulinemia

Search GEO for disease gene expression data for Waldenstroem's Macroglobulinemia.

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Pathways for Waldenstroem's Macroglobulinemia

Pathways related to Waldenstroem's Macroglobulinemia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Antigen processing-Cross presentation ⁶⁶ Show member pathways Cross-presentation of particulate exogenous antigens (phagosomes) ⁶⁶ Endosomal/Vacuolar pathway ⁶⁶ ER-Phagosome pathway ⁶⁶ Immune response Antigen presentation by MHC class I ²²	12.03	B2M BTK MYD88
2	Epstein-Barr virus infection ³⁷	11.76	B2M BTK CD19 MYD88
3	NF-kappaB Signaling ⁴	11.61	B2M BTK CD19 CD38 CXCR4 MYD88
4	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.56	CD19 CD38 CD5
5	Hematopoietic cell lineage ³⁷	11.42	CD19 CD38 CD5
6	B Cell Development Pathways ⁶⁵	10.98	CD19 CD38 CD5 CXCR4
7	Primary immunodeficiency ³⁷	10.94	BTK CD19

Sources

GO Terms for Waldenstroem's Macroglobulinemia

Cellular components related to Waldenstroem's Macroglobulinemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	9.56	B2M BTK CD19 CD38 CD5 CXCR4
2	external side of plasma membrane	GO:0009897	8.92	B2M CD19 CD5 CXCR4

Biological processes related to Waldenstroem's Macroglobulinemia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	B cell receptor signaling pathway	GO:0050853	9.33	BTK CD19 CD38
2	MyD88-dependent toll-like receptor signaling pathway	GO:0002755	9.32	BTK MYD88
3	response to interleukin-1	GO:0070555	9.26	CD38 MYD88
4	apoptotic signaling pathway	GO:0097190	9.13	BTK CD38 CD5
5	negative regulation of neuron projection development	GO:0010977	8.8	B2M CD38 MAG

Sources

Sources for Waldenstroem's Macroglobulinemia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia