MCID: WLD007
MIFTS: 35

Waldenstroem's Macroglobulinemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Waldenstroem's Macroglobulinemia

MalaCards integrated aliases for Waldenstroem's Macroglobulinemia:

Name: Waldenstroem's Macroglobulinemia 12 15
Lymphoplasmacytic Lymphoma with Igm Gammopathy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060901
ICD10 33 C88.0
ICD9CM 35 273.3
MeSH 44 D008258
NCIt 50 C80307
SNOMED-CT 68 35562000
UMLS 73 C0024419

Summaries for Waldenstroem's Macroglobulinemia

Disease Ontology : 12 A lymphoplasmacytic lymphoma characterized by the accumulation of monoclonal cells in the bone marrow and peripheral lymphoid tissues, and associated with the production of serum immunoglobulin M (IgM) monoclonal protein.

MalaCards based summary : Waldenstroem's Macroglobulinemia, also known as lymphoplasmacytic lymphoma with igm gammopathy, is related to isolated growth hormone deficiency type iii and mononeuritis multiplex. An important gene associated with Waldenstroem's Macroglobulinemia is MYD88 (MYD88, Innate Immune Signal Transduction Adaptor), and among its related pathways/superpathways are Antigen processing-Cross presentation and Epstein-Barr virus infection. The drugs leucovorin and Bortezomib have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and lung, and related phenotypes are hematopoietic system and cellular

Related Diseases for Waldenstroem's Macroglobulinemia

Diseases related to Waldenstroem's Macroglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 isolated growth hormone deficiency type iii 10.2 BTK KMT2D
2 mononeuritis multiplex 10.2 MAG MYOM2
3 mononeuritis of upper limb and mononeuritis multiplex 10.2 MAG MYOM2
4 chronic polyneuropathy 10.2 MAG MYOM2
5 osteosclerotic myeloma 10.1 MAG MYOM2
6 irak4 deficiency 10.1 BTK MYD88
7 myd88 deficiency 10.1 BTK MYD88
8 pleuropneumonia 10.1 CD19 MYD88
9 ecthyma 10.1 BTK MYOM2
10 congenital hypogammaglobulinemia 10.1 BTK CD19
11 bladder lymphoma 10.1 CD19 CD5
12 colon lymphoma 10.1 CD19 CD5
13 invasive malignant thymoma 10.1 CD19 CD38
14 marginal zone b-cell lymphoma 10.0 CD5 KMT2D MYD88
15 cll/sll 10.0 CD38 CD5
16 diffuse large b-cell lymphoma 10.0 CD5 KMT2D MYD88
17 richter's syndrome 10.0 CD38 CD5
18 lung lymphoma 10.0 CD19 CD5
19 diffuse infiltrative lymphocytosis syndrome 10.0 CD19 CD38
20 indolent myeloma 10.0 B2M MYOM2
21 extramedullary plasmacytoma 10.0 B2M MYOM2
22 lymphatic system cancer 10.0 CD19 CD5
23 transient hypogammaglobulinemia of infancy 10.0 BTK CD19
24 amyloid tumor 10.0 B2M MYOM2
25 b cell deficiency 10.0 BTK CD19 KMT2D
26 polyradiculoneuropathy 10.0 CXCR4 MAG
27 macroglobulinemia 10.0 BTK CXCR4 MYD88
28 intravascular large b-cell lymphoma 10.0 B2M CD5
29 plasmacytoma 10.0 B2M CD38
30 lymphoma, hodgkin, classic 10.0 CD19 CD5
31 gamma heavy chain disease 10.0 CD19 CD38 MYD88
32 mantle cell lymphoma 9.9 BTK CD19 CD5
33 b cell prolymphocytic leukemia 9.9 CD19 CD38 CD5
34 small intestine lymphoma 9.9 B2M CD19
35 prolymphocytic leukemia 9.9 CD19 CD38 CD5
36 aids dementia complex 9.9 B2M CXCR4
37 common variable immunodeficiency 9.9 BTK CD19 CD38
38 immune deficiency disease 9.8 BTK CD19
39 lymphocytic leukemia 9.8 BTK CD38 CD5 MYD88
40 waldenstrom macroglobulinemia 9.8 BTK CXCR4 MAG MYD88
41 bone marrow cancer 9.8 B2M CD38 MYOM2
42 anterior scleritis 9.8 B2M CD19 CD5
43 b-cell expansion with nfkb and t-cell anergy 9.8 B2M CD38 CD5
44 human immunodeficiency virus infectious disease 9.7 B2M CD38 CXCR4
45 non-secretory myeloma 9.6 B2M CD19 CD38 MYOM2
46 solitary osseous plasmacytoma 9.6 B2M CD19 CD38 MYOM2
47 leukemia, acute myeloid 9.6 CD19 CD38 CXCR4
48 human immunodeficiency virus type 1 9.6 B2M CD38 CXCR4
49 hematologic cancer 9.5 CD19 CD38 CD5 CXCR4 KMT2D
50 plasma cell neoplasm 9.5 B2M CD19 CD38 MAG MYOM2

Graphical network of the top 20 diseases related to Waldenstroem's Macroglobulinemia:



Diseases related to Waldenstroem's Macroglobulinemia

Symptoms & Phenotypes for Waldenstroem's Macroglobulinemia

MGI Mouse Phenotypes related to Waldenstroem's Macroglobulinemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 B2M BTK CD19 CD38 CD5 CXCR4
2 cellular MP:0005384 9.95 B2M BTK CD19 CD38 CXCR4 KMT2D
3 homeostasis/metabolism MP:0005376 9.86 B2M BTK CD19 CD38 CXCR4 KMT2D
4 immune system MP:0005387 9.81 B2M BTK CD19 CD38 CD5 CXCR4
5 digestive/alimentary MP:0005381 9.77 B2M BTK CD19 CXCR4 MYD88
6 neoplasm MP:0002006 9.43 B2M BTK CD19 CXCR4 KMT2D MYD88
7 nervous system MP:0003631 9.17 B2M CD19 CD5 CXCR4 KMT2D MAG

Drugs & Therapeutics for Waldenstroem's Macroglobulinemia

Drugs for Waldenstroem's Macroglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 1 58-05-9 6006 143
2
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
4 Vitamin B9 Phase 1
5 Folic Acid Antagonists Phase 1
6 Folate Phase 1
7 Vitamin B Complex Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Bortezomib (VELCADE) in Combo With Pralatrexate in Relapsed/Refractory MM Completed NCT01114282 Phase 1 velcade;Pralatrexate

Search NIH Clinical Center for Waldenstroem's Macroglobulinemia

Genetic Tests for Waldenstroem's Macroglobulinemia

Anatomical Context for Waldenstroem's Macroglobulinemia

MalaCards organs/tissues related to Waldenstroem's Macroglobulinemia:

41
Bone, Bone Marrow, Lung, Colon, B Cells, Myeloid, Small Intestine

Publications for Waldenstroem's Macroglobulinemia

Articles related to Waldenstroem's Macroglobulinemia:

# Title Authors Year
1
Cryptococcal pleural effusion in an HTLV-I carrier with Waldenstroem's macroglobulinemia. ( 1561905 )
1992
2
WALDENSTROEM'S MACROGLOBULINEMIA WITH TRANSIENT CHOLESTATIC JAUNDICE; CASE REPORT. ( 14273609 )
1965
3
CLINICAL ASPECTS OF WALDENSTROEM'S MACROGLOBULINEMIA. WITH REPORT OF A CASE. ( 14098291 )
1963

Variations for Waldenstroem's Macroglobulinemia

Expression for Waldenstroem's Macroglobulinemia

Search GEO for disease gene expression data for Waldenstroem's Macroglobulinemia.

Pathways for Waldenstroem's Macroglobulinemia

GO Terms for Waldenstroem's Macroglobulinemia

Cellular components related to Waldenstroem's Macroglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.56 B2M BTK CD19 CD38 CD5 CXCR4
2 external side of plasma membrane GO:0009897 8.92 B2M CD19 CD5 CXCR4

Biological processes related to Waldenstroem's Macroglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell receptor signaling pathway GO:0050853 9.33 BTK CD19 CD38
2 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.32 BTK MYD88
3 response to interleukin-1 GO:0070555 9.26 CD38 MYD88
4 apoptotic signaling pathway GO:0097190 9.13 BTK CD38 CD5
5 negative regulation of neuron projection development GO:0010977 8.8 B2M CD38 MAG

Sources for Waldenstroem's Macroglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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