MCID: WLD007
MIFTS: 35

Waldenstroem's Macroglobulinemia

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Waldenstroem's Macroglobulinemia

MalaCards integrated aliases for Waldenstroem's Macroglobulinemia:

Name: Waldenstroem's Macroglobulinemia 12 15
Lymphoplasmacytic Lymphoma with Igm Gammopathy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060901
ICD9CM 36 273.3
MeSH 45 D008258
NCIt 51 C80307
SNOMED-CT 69 35562000
ICD10 34 C88.0
UMLS 74 C0024419

Summaries for Waldenstroem's Macroglobulinemia

Disease Ontology : 12 A lymphoplasmacytic lymphoma characterized by the accumulation of monoclonal cells in the bone marrow and peripheral lymphoid tissues, and associated with the production of serum immunoglobulin M (IgM) monoclonal protein.

MalaCards based summary : Waldenstroem's Macroglobulinemia, also known as lymphoplasmacytic lymphoma with igm gammopathy, is related to macroglobulinemia and mononeuritis multiplex. An important gene associated with Waldenstroem's Macroglobulinemia is MYD88 (MYD88 Innate Immune Signal Transduction Adaptor), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Antigen processing-Cross presentation. The drugs leucovorin and Bortezomib have been mentioned in the context of this disorder. Affiliated tissues include bone and bone marrow, and related phenotypes are Reduced mammosphere formation and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Waldenstroem's Macroglobulinemia

Diseases related to Waldenstroem's Macroglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 macroglobulinemia 30.5 MYD88 CXCR4 CD27 BTK
2 mononeuritis multiplex 10.3 MAG MYOM2
3 mononeuritis of upper limb and mononeuritis multiplex 10.2 MAG MYOM2
4 chronic polyneuropathy 10.2 MAG MYOM2
5 osteosclerotic myeloma 10.2 MAG MYOM2
6 irak4 deficiency 10.2 BTK MYD88
7 congenital hypogammaglobulinemia 10.2 BTK CD19
8 myd88 deficiency 10.2 BTK MYD88
9 indolent myeloma 10.2 B2M MYOM2
10 monoclonal paraproteinemia 10.2 CD27 MYD88
11 pleuropneumonia 10.2 CD19 MYD88
12 aids dementia complex 10.2 B2M CXCR4
13 extramedullary plasmacytoma 10.2 B2M MYOM2
14 bladder lymphoma 10.1 CD19 CD5
15 intravascular large b-cell lymphoma 10.1 B2M CD5
16 ecthyma 10.1 BTK MYOM2
17 amyloid tumor 10.1 B2M MYOM2
18 epidural neoplasm 10.1 CD27 CD5
19 invasive malignant thymoma 10.0 CD19 CD38
20 cll/sll 10.0 CD38 CD5
21 marginal zone b-cell lymphoma 10.0 CD5 MYD88
22 diffuse infiltrative lymphocytosis syndrome 10.0 CD19 CD38
23 richter's syndrome 10.0 CD38 CD5
24 mantle cell lymphoma 10.0 BTK CD19 CD5
25 waldenstrom macroglobulinemia 10.0 MYD88 MAG CXCR4 BTK
26 cloacogenic carcinoma 10.0 B2M CD27
27 lymphatic system cancer 9.9 CD19 CD5
28 transient hypogammaglobulinemia of infancy 9.9 BTK CD19 CD27
29 posterior scleritis 9.9 CD19 CD22
30 b cell deficiency 9.9 BTK CD19 CD27
31 gamma heavy chain disease 9.9 CD19 CD38 MYD88
32 human immunodeficiency virus infectious disease 9.8 B2M CD38 CXCR4
33 lateral medullary syndrome 9.8 CD19 CD22
34 b cell prolymphocytic leukemia 9.8 CD19 CD38 CD5
35 prolymphocytic leukemia 9.8 CD19 CD38 CD5
36 hemophagocytic lymphohistiocytosis 9.8 B2M CD27 CD5
37 bone marrow cancer 9.8 B2M CD38 MYOM2
38 b-cell expansion with nfkb and t-cell anergy 9.8 B2M CD38 CD5
39 lymphosarcoma 9.8 CD22 CD5
40 lymphocytic leukemia 9.8 BTK CD38 CD5 MYD88
41 cryoglobulinemia 9.7 CD27 CD5
42 colon lymphoma 9.7 CD19 CD22 CD5
43 lung lymphoma 9.7 CD19 CD22 CD5
44 lymphoma, hodgkin, classic 9.7 CD19 CD22 CD5
45 small intestine lymphoma 9.7 B2M CD19 CD22
46 non-secretory myeloma 9.6 MYOM2 CD38 CD19 B2M
47 common variable immunodeficiency 9.6 BTK CD19 CD27 CD38
48 anterior scleritis 9.4 CD5 CD22 CD19 B2M
49 leukemia, acute myeloid 9.4 CD19 CD22 CD38 CXCR4
50 mature b-cell neoplasm 9.4 MYOM2 MAG CD38 CD19 B2M

Graphical network of the top 20 diseases related to Waldenstroem's Macroglobulinemia:



Diseases related to Waldenstroem's Macroglobulinemia

Symptoms & Phenotypes for Waldenstroem's Macroglobulinemia

GenomeRNAi Phenotypes related to Waldenstroem's Macroglobulinemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.35 CD22 CD27 CD5 MAG MYD88
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 CXCR4 MYD88
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 BTK CD27 CD38 CXCR4 MYD88

MGI Mouse Phenotypes related to Waldenstroem's Macroglobulinemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.92 B2M BTK CD19 CD22 CD27 CD38
2 hematopoietic system MP:0005397 9.85 B2M BTK CD19 CD22 CD27 CD38
3 digestive/alimentary MP:0005381 9.65 B2M BTK CD19 CXCR4 MYD88
4 immune system MP:0005387 9.65 B2M BTK CD19 CD22 CD27 CD38
5 neoplasm MP:0002006 9.02 B2M BTK CD19 CXCR4 MYD88

Drugs & Therapeutics for Waldenstroem's Macroglobulinemia

Drugs for Waldenstroem's Macroglobulinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 1 58-05-9 6006 143
2
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
4 Vitamin B Complex Phase 1
5 Folic Acid Antagonists Phase 1
6 Folate Phase 1
7 Vitamin B9 Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Bortezomib (VELCADE) in Combo With Pralatrexate in Relapsed/Refractory MM Completed NCT01114282 Phase 1 velcade;Pralatrexate

Search NIH Clinical Center for Waldenstroem's Macroglobulinemia

Genetic Tests for Waldenstroem's Macroglobulinemia

Anatomical Context for Waldenstroem's Macroglobulinemia

MalaCards organs/tissues related to Waldenstroem's Macroglobulinemia:

42
Bone, Bone Marrow

Publications for Waldenstroem's Macroglobulinemia

Articles related to Waldenstroem's Macroglobulinemia:

# Title Authors Year
1
Cryptococcal pleural effusion in an HTLV-I carrier with Waldenstroem's macroglobulinemia. ( 1561905 )
1992
2
WALDENSTROEM'S MACROGLOBULINEMIA WITH TRANSIENT CHOLESTATIC JAUNDICE; CASE REPORT. ( 14273609 )
1965
3
CLINICAL ASPECTS OF WALDENSTROEM'S MACROGLOBULINEMIA. WITH REPORT OF A CASE. ( 14098291 )
1963

Variations for Waldenstroem's Macroglobulinemia

Expression for Waldenstroem's Macroglobulinemia

Search GEO for disease gene expression data for Waldenstroem's Macroglobulinemia.

Pathways for Waldenstroem's Macroglobulinemia

Pathways related to Waldenstroem's Macroglobulinemia according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 B2M BTK CD19 CD22 MYD88
2
Show member pathways
12.1 B2M BTK MYD88
3
Show member pathways
12.01 BTK CD19 CD22
4 11.95 B2M BTK CD19 CD38 CXCR4 MYD88
5
Show member pathways
11.91 BTK CD19 CD22
6 11.67 B2M CD19 CD22
7 11.62 CD19 CD22 CD38 CD5
8
Show member pathways
11.52 BTK CD19 CD22
9 11.44 CD19 CD22 CD38 CD5
10 11 BTK CD19
11 10.82 CD19 CD22 CD27 CD38 CD5 CXCR4

GO Terms for Waldenstroem's Macroglobulinemia

Cellular components related to Waldenstroem's Macroglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.65 B2M BTK CD19 CD22 CD27 CD38
2 cell surface GO:0009986 9.55 B2M CD22 CD27 CD38 CXCR4
3 external side of plasma membrane GO:0009897 9.02 B2M CD19 CD27 CD5 CXCR4

Biological processes related to Waldenstroem's Macroglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.76 BTK CD27 CXCR4 MYD88
2 regulation of immune response GO:0050776 9.61 B2M CD19 CD22
3 B cell receptor signaling pathway GO:0050853 9.5 BTK CD19 CD38
4 cell surface receptor signaling pathway GO:0007166 9.48 CD27 MYD88
5 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.4 BTK MYD88
6 response to interleukin-1 GO:0070555 9.37 CD38 MYD88
7 immunoglobulin mediated immune response GO:0016064 9.26 CD27 MYD88
8 positive regulation of B cell differentiation GO:0045579 9.16 BTK CD27
9 apoptotic signaling pathway GO:0097190 9.13 BTK CD38 CD5
10 negative regulation of neuron projection development GO:0010977 8.8 B2M CD38 MAG

Molecular functions related to Waldenstroem's Macroglobulinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sialic acid binding GO:0033691 8.62 CD22 MAG

Sources for Waldenstroem's Macroglobulinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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