MCID: WLL004
MIFTS: 40

Wallerian Degeneration

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Wallerian Degeneration

MalaCards integrated aliases for Wallerian Degeneration:

Name: Wallerian Degeneration 54 56 74
Wallerian Degeneration of the Pyramidal Tract 54

Classifications:



External Ids:

UMLS 74 C0043020

Summaries for Wallerian Degeneration

MalaCards based summary : Wallerian Degeneration, also known as wallerian degeneration of the pyramidal tract, is related to charcot-marie-tooth disease and spinal cord injury. An important gene associated with Wallerian Degeneration is NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Choline and Nootropic Agents have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and cortex, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Wallerian degeneration is an active process of degeneration that results when a nerve fiber is cut or... more...

Related Diseases for Wallerian Degeneration

Diseases related to Wallerian Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 charcot-marie-tooth disease 29.0 CNTF MAG MPZ NEFM
2 spinal cord injury 10.4
3 multiple sclerosis 10.4
4 neuropathy 10.4
5 ischemia 10.3
6 neutrophil actin dysfunction 10.3
7 stroke, ischemic 10.3
8 brain injury 10.3
9 relapsing-remitting multiple sclerosis 10.2
10 middle cerebral artery infarction 10.1
11 traumatic brain injury 10.1
12 hypoxia 10.1
13 krabbe disease 10.0
14 sudanophilic cerebral sclerosis 10.0
15 hemorrhage, intracerebral 10.0
16 hyperprolactinemia 10.0
17 retinal ischemia 10.0
18 spinal muscular atrophy 10.0
19 lymphoma 10.0
20 pain agnosia 10.0
21 agraphia 10.0
22 thrombosis 10.0
23 thymus lymphoma 10.0
24 leukodystrophy 10.0
25 tooth disease 10.0
26 hemiplegia 10.0
27 mononeuropathy 10.0
28 alexia 10.0
29 beriberi 10.0
30 neuritis 10.0
31 germinoma 10.0
32 dysgraphia 10.0
33 peripheral nervous system disease 10.0
34 progressive multifocal leukoencephalopathy 10.0
35 prion disease 10.0
36 muscular atrophy 10.0
37 myocarditis 10.0
38 encephalitis 10.0
39 genetic prion diseases 10.0
40 hypertrophic olivary degeneration 10.0
41 cerebral hypoxia 10.0
42 dysautonomia 10.0
43 encephalopathy 10.0
44 head injury 10.0
45 acute sensory ataxic neuropathy 10.0
46 optic neuritis 9.7 CNTF MAG MPZ
47 autoimmune peripheral neuropathy 9.6 CLU MAG MPZ
48 amyotrophic lateral sclerosis 1 9.1 CNTF MAG NEFM PLEKHB1

Graphical network of the top 20 diseases related to Wallerian Degeneration:



Diseases related to Wallerian Degeneration

Symptoms & Phenotypes for Wallerian Degeneration

GenomeRNAi Phenotypes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

27 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.55 UBE4B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.55 CNTF
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.55 CNTF ERBB2 SEMA3A UBE4B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.55 CNTF
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.55 UBE4B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.55 UBE4B
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.55 CNTF
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.55 CNTF SEMA3A
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.55 SEMA3A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.55 SEMA3A
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.55 ERBB2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.55 ERBB2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.55 CNTF
14 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.35 ERBB2 NRP2 SEMA3A SEMA3F VEGFA

MGI Mouse Phenotypes related to Wallerian Degeneration:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 CLU CNTF ERBB2 MAG MPZ NMNAT1
2 cellular MP:0005384 10.1 CNTF ERBB2 MPZ NMNAT2 NRP2 ODC1
3 homeostasis/metabolism MP:0005376 10 CLU CNTF ERBB2 MAG MPZ NRP2
4 mortality/aging MP:0010768 9.93 ERBB2 MPZ NMNAT1 NMNAT2 NRP2 ODC1
5 muscle MP:0005369 9.5 CLU CNTF ERBB2 NMNAT2 NRP2 UBE4B
6 nervous system MP:0003631 9.5 CLU CNTF ERBB2 MAG MPZ NMNAT1

Drugs & Therapeutics for Wallerian Degeneration

Drugs for Wallerian Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Choline Approved, Nutraceutical Phase 4 62-49-7 305
2 Nootropic Agents Phase 4
3 Cytidine Diphosphate Choline Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
2 Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain Completed NCT03327220 Not Applicable
3 Focal Cortical Atrophy After Myocardial Internal Capsule Completed NCT01862172 Not Applicable
4 Cryoneurolysis of Arnold's Nerve and Follow-up by Tractography: Feasibility Study Not yet recruiting NCT03735914 Not Applicable

Search NIH Clinical Center for Wallerian Degeneration

Genetic Tests for Wallerian Degeneration

Anatomical Context for Wallerian Degeneration

MalaCards organs/tissues related to Wallerian Degeneration:

42
Spinal Cord, Brain, Cortex, Monocytes, Bone Marrow, Neutrophil, Smooth Muscle

Publications for Wallerian Degeneration

Articles related to Wallerian Degeneration:

(show top 50) (show all 604)
# Title Authors Year
1
Combined hypertrophic olivary degeneration and Wallerian degeneration of the bilateral middle cerebellar peduncles: a case report. ( 30941625 )
2019
2
Wallerian Degeneration in Experimental Focal Cortical Ischemia. ( 31051228 )
2019
3
NMNAT Proteins that Limit Wallerian Degeneration Also Regulate Critical Period Plasticity in the Visual Cortex. ( 30671537 )
2019
4
Rapid depletion of ESCRT protein Vps4 underlies injury-induced autophagic impediment and Wallerian degeneration. ( 30788439 )
2019
5
The Complex Work of Proteases and Secretases in Wallerian Degeneration: Beyond Neuregulin-1. ( 30949030 )
2019
6
Genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury. ( 31097218 )
2019
7
Bilateral wallerian degeneration of the middle cerebellar peduncles secondary to pontine infarction: A case series. ( 29627018 )
2018
8
P7C3-A20 neuroprotection is independent of Wallerian degeneration in primary neuronal culture. ( 30334859 )
2018
9
Wallerian degeneration of the bilateral middle cerebellar peduncles secondary to pontine infarction. ( 29285691 )
2018
10
Clinical and Radiological Features of Wallerian Degeneration of the Middle Cerebellar Peduncles Secondary to Pontine Infarction. ( 29521288 )
2018
11
Systemic Transplantation of Bone Marrow Mononuclear Cells Promotes Axonal Regeneration and Analgesia in a Model of Wallerian Degeneration. ( 27607534 )
2017
12
Neurographic course Of Wallerian degeneration after human peripheral nerve injury. ( 27875622 )
2017
13
GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. ( 28053206 )
2017
14
Wallerian Degeneration Beyond the Corticospinal Tracts: Conventional and Advanced MRI Findings. ( 28072502 )
2017
15
An assessment of the correlation between early postinfarction pyramidal tract Wallerian degeneration and nerve function recovery using diffusion tensor imaging. ( 28128402 )
2017
16
Microarray and qPCR Analyses of Wallerian Degeneration in Rat Sciatic Nerves. ( 28239339 )
2017
17
NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo. ( 28262487 )
2017
18
Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons. ( 28285993 )
2017
19
Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis. ( 28302146 )
2017
20
Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons. ( 28441556 )
2017
21
Deficiency of adaptive immunity does not interfere with Wallerian degeneration. ( 28475650 )
2017
22
Critical signaling pathways during Wallerian degeneration of peripheral nerve. ( 28761435 )
2017
23
Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration. ( 28912156 )
2017
24
Teaching NeuroImages: Wallerian degeneration in evolving pediatric stroke. ( 28947589 )
2017
25
Potential Use of 18F-THK5351 PET to Identify Wallerian Degeneration of the Pyramidal Tract Caused by Cerebral Infarction. ( 29076904 )
2017
26
Autophagic myelin destruction by Schwann cells during Wallerian degeneration and segmental demyelination. ( 26712109 )
2016
27
Wallerian degeneration of the pontocerebellar fibres secondary to pontine infarction. ( 26712359 )
2016
28
Molecular mechanisms in the initiation phase of Wallerian degeneration. ( 27062141 )
2016
29
Polyethylene glycol-fusion retards Wallerian degeneration and rapidly restores behaviors lost after nerve severance. ( 27073362 )
2016
30
Prolonged Wallerian degeneration in the corticospinal tract following external capsular hemorrhage. ( 27206896 )
2016
31
Wallerian Degeneration in the Corticospinal Tract Following Tumefactive Demyelination: Conventional and Advanced Magnetic Resonance Imaging. ( 27417915 )
2016
32
Avian axons undergo Wallerian degeneration after injury and stress. ( 27614771 )
2016
33
An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2. ( 27732853 )
2016
34
MRI findings in a case of spinal cord Wallerian degeneration following trauma. ( 27744468 )
2016
35
Toll-Like Receptor 3 Contributes to Wallerian Degeneration after Peripheral Nerve Injury. ( 27771719 )
2016
36
Ingenuity Pathway Analysis of Gene Expression Profiles in Distal Nerve Stump following Nerve Injury: Insights into Wallerian Degeneration. ( 27999531 )
2016
37
T2/Fluid Attenuation Inversion Recovery Hypointensity of Corticospinal Tracts due to Subacute Stage of Wallerian Degeneration. ( 28163512 )
2016
38
Wallerian degeneration and recovery of motor nerves after multiple focused cold therapies. ( 24895229 )
2015
39
Wallerian degeneration in the optic nerve stretch-injury model of traumatic brain injury: a stereological analysis. ( 25333317 )
2015
40
Early Wallerian degeneration in a neonate with middle carotid artery stroke. ( 25443582 )
2015
41
TGF-β1 is critical for Wallerian degeneration after rat sciatic nerve injury. ( 25451291 )
2015
42
Wallerian degeneration of the bilateral middle cerebellar peduncles. ( 25586535 )
2015
43
Bilateral Wallerian Degeneration of the Pontocerebellar Tracts. ( 26171260 )
2015
44
Longitudinal three-dimensional-T2WI-SPACE study on wallerian degeneration in cat corticospinal tract and underlying pathology changes. ( 26218829 )
2015
45
Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury. ( 26419777 )
2015
46
Wallerian Degeneration of the Superior Cerebellar Peduncle. ( 26457633 )
2015
47
Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca(2+) Influx but Only Modestly Influenced by Mitochondria. ( 26686637 )
2015
48
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
49
Protein expression profiling during wallerian degeneration after rat sciatic nerve injury. ( 24123051 )
2014
50
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. ( 24252177 )
2014

Variations for Wallerian Degeneration

Expression for Wallerian Degeneration

Search GEO for disease gene expression data for Wallerian Degeneration.

Pathways for Wallerian Degeneration

Pathways related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 CLU MAG NEFM NRP2
2 10.7 CNTF NEFM VEGFA

GO Terms for Wallerian Degeneration

Cellular components related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 paranode region of axon GO:0033270 9.32 MAG SIRT2
2 Schmidt-Lanterman incisure GO:0043220 9.26 MAG SIRT2
3 myelin sheath GO:0043209 9.26 ERBB2 MAG MPZ SIRT2
4 neurofibrillary tangle GO:0097418 9.16 CLU NEFM
5 axon GO:0030424 9.1 CNTF NEFM NMNAT2 NRP2 SARM1 SEMA3A
6 cytoplasm GO:0005737 10.18 CLU CNTF ERBB2 MAG NMNAT1 NMNAT2

Biological processes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron apoptotic process GO:0043524 9.83 CNTF MAG NMNAT1
2 neural crest cell migration GO:0001755 9.74 NRP2 SEMA3A SEMA3F
3 semaphorin-plexin signaling pathway GO:0071526 9.72 NRP2 SEMA3A SEMA3F
4 negative chemotaxis GO:0050919 9.71 NRP2 SEMA3A SEMA3F
5 motor neuron axon guidance GO:0008045 9.65 ERBB2 SEMA3A
6 negative regulation of axon extension GO:0030517 9.65 MAG SEMA3A
7 nerve development GO:0021675 9.65 NRP2 SEMA3A SEMA3F
8 regulation of neuron death GO:1901214 9.64 CLU SARM1
9 regulation of postsynapse organization GO:0099175 9.64 NRP2 SEMA3F
10 NAD metabolic process GO:0019674 9.63 NMNAT1 NMNAT2
11 vascular endothelial growth factor signaling pathway GO:0038084 9.63 NRP2 VEGFA
12 facial nerve structural organization GO:0021612 9.63 NRP2 SEMA3A SEMA3F
13 NAD biosynthetic process GO:0009435 9.62 NMNAT1 NMNAT2
14 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.62 MAG MPZ
15 pyridine nucleotide biosynthetic process GO:0019363 9.61 NMNAT1 NMNAT2
16 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.61 SEMA3A SEMA3F
17 sympathetic ganglion development GO:0061549 9.61 NRP2 SEMA3A SEMA3F
18 axonogenesis involved in innervation GO:0060385 9.6 NPTX1 SEMA3A
19 branchiomotor neuron axon guidance GO:0021785 9.59 SEMA3A SEMA3F
20 trigeminal ganglion development GO:0061551 9.58 NRP2 SEMA3A
21 trigeminal nerve structural organization GO:0021637 9.58 SEMA3A SEMA3F
22 axon extension involved in axon guidance GO:0048846 9.58 NRP2 SEMA3A SEMA3F
23 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.54 NRP2 SEMA3A SEMA3F
24 'de novo' NAD biosynthetic process from aspartate GO:0034628 9.52 NMNAT1 NMNAT2
25 facioacoustic ganglion development GO:1903375 9.51 NRP2 SEMA3A
26 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 9.5 NRP2 SEMA3A SEMA3F
27 gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 9.49 NRP2 SEMA3A
28 sympathetic neuron projection extension GO:0097490 9.43 NRP2 SEMA3A SEMA3F
29 sympathetic neuron projection guidance GO:0097491 9.33 NRP2 SEMA3A SEMA3F
30 nervous system development GO:0007399 9.23 CNTF ERBB2 MAG NRP2 SARM1 SEMA3A
31 ventral trunk neural crest cell migration GO:0036486 9.13 NRP2 SEMA3A SEMA3F
32 cell differentiation GO:0030154 10.03 CNTF NRP2 SARM1 SEMA3A SIRT2 VEGFA

Molecular functions related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 semaphorin receptor binding GO:0030215 9.26 SEMA3A SEMA3F
2 neuropilin binding GO:0038191 9.16 SEMA3A SEMA3F
3 nicotinate-nucleotide adenylyltransferase activity GO:0004515 8.96 NMNAT1 NMNAT2
4 nicotinamide-nucleotide adenylyltransferase activity GO:0000309 8.62 NMNAT1 NMNAT2

Sources for Wallerian Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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