MCID: WLL004
MIFTS: 38

Wallerian Degeneration

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Wallerian Degeneration

MalaCards integrated aliases for Wallerian Degeneration:

Name: Wallerian Degeneration 20 54 71
Wallerian Degeneration of the Pyramidal Tract 20

Classifications:



External Ids:

UMLS 71 C0043020

Summaries for Wallerian Degeneration

MalaCards based summary : Wallerian Degeneration, also known as wallerian degeneration of the pyramidal tract, is related to hereditary neuropathies and neuritis. An important gene associated with Wallerian Degeneration is NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Racepinephrine and Nitrous oxide have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, dorsal root ganglion and cortex, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 74 Wallerian degeneration is an active process of degeneration that results when a nerve fiber is cut or... more...

Related Diseases for Wallerian Degeneration

Diseases related to Wallerian Degeneration via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 hereditary neuropathies 30.0 MPZ MAG
2 neuritis 29.9 VEGFA MPZ MAG CNTF
3 peripheral nervous system disease 29.7 VEGFA MPZ MAG ERBB2 CNTF
4 motor neuron disease 29.1 VEGFA NEFM MPZ MAG CNTF
5 charcot-marie-tooth disease 29.1 NEFM MPZ MAG ERBB2 CNTF
6 spinal cord injury 10.5
7 middle cerebral artery infarction 10.3
8 cytokine deficiency 10.3
9 brain injury 10.3
10 traumatic brain injury 10.2
11 bullous retinoschisis 10.2 VEGFA SARM1
12 hemiplegia 10.2
13 cerebrovascular disease 10.2
14 neuropathy 10.2
15 autoimmune peripheral neuropathy 10.1 MPZ MAG
16 primary peritoneal carcinoma 10.1 VEGFA ERBB2
17 autoimmune neuropathy 10.1 MPZ MAG
18 amyotrophic lateral sclerosis 1 10.1
19 multiple sclerosis 10.1
20 supranuclear palsy, progressive, 1 10.1
21 tooth disease 10.1
22 mononeuropathy 10.1
23 spinal muscular atrophy 10.1
24 retinal ischemia 10.1
25 guillain-barre syndrome 10.1
26 lateral sclerosis 10.1
27 relapsing-remitting multiple sclerosis 10.1
28 temporal lobe epilepsy 10.1
29 scrapie 10.1
30 muscular atrophy 10.1
31 hypertrophic olivary degeneration 10.1
32 hypoxia 10.1
33 argyria 10.1
34 lung non-squamous non-small cell carcinoma 10.1 VEGFA ERBB2
35 osteosclerotic myeloma 10.1 VEGFA MAG
36 gastroesophageal junction adenocarcinoma 10.0 VEGFA ERBB2
37 ischemic neuropathy 10.0 VEGFA CNTF
38 alzheimer disease 9.9
39 charcot-marie-tooth disease, demyelinating, type 1a 9.9
40 creutzfeldt-jakob disease 9.9
41 huntington disease 9.9
42 hypercholesterolemia, familial, 1 9.9
43 neuropathy, hereditary, with liability to pressure palsies 9.9
44 ocular dominance 9.9
45 polykaryocytosis inducer 9.9
46 krabbe disease 9.9
47 sudanophilic cerebral sclerosis 9.9
48 adrenoleukodystrophy 9.9
49 ataxia and polyneuropathy, adult-onset 9.9
50 charcot-marie-tooth disease, demyelinating, type 1c 9.9

Graphical network of the top 20 diseases related to Wallerian Degeneration:



Diseases related to Wallerian Degeneration

Symptoms & Phenotypes for Wallerian Degeneration

GenomeRNAi Phenotypes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

26 (show all 31)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-3 9.98 ERBB2
2 Decreased viability GR00221-A-4 9.98 ERBB2
3 Decreased viability GR00249-S 9.98 MPZ NMNAT2 NRP2 VEGFA
4 Decreased viability GR00381-A-1 9.98 MPZ NPTX1 PLEKHB1 UBA1
5 Decreased viability GR00381-A-3 9.98 MPZ
6 Decreased viability GR00386-A-1 9.98 MPZ NEFM ODC1 UBE4B
7 Decreased viability GR00402-S-2 9.98 CNTF MPZ ODC1 SARM1 SEMA3F UBA1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.72 CNTF
9 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.72 UBE4B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.72 CNTF SEMA3A
11 Increased shRNA abundance (Z-score > 2) GR00366-A-158 9.72 UBE4B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.72 CNTF
13 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.72 ERBB2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.72 ERBB2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.72 SEMA3A
16 Increased shRNA abundance (Z-score > 2) GR00366-A-187 9.72 CNTF
17 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.72 UBE4B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.72 CNTF
19 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.72 ERBB2
20 Increased shRNA abundance (Z-score > 2) GR00366-A-22 9.72 UBE4B
21 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.72 UBE4B
22 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.72 ERBB2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-33 9.72 CNTF
24 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.72 UBE4B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-56 9.72 CNTF
26 Increased shRNA abundance (Z-score > 2) GR00366-A-60 9.72 ERBB2
27 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.72 ERBB2
28 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.72 ERBB2
29 Increased shRNA abundance (Z-score > 2) GR00366-A-87 9.72 ERBB2
30 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.72 UBE4B
31 Increased shRNA abundance (Z-score > 2) GR00366-A-95 9.72 CNTF

MGI Mouse Phenotypes related to Wallerian Degeneration:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.13 CLU CNTF ERBB2 MAG MPZ NMNAT1
2 cellular MP:0005384 9.97 CNTF ERBB2 MPZ NMNAT1 NMNAT2 NRP2
3 muscle MP:0005369 9.5 CLU CNTF ERBB2 NMNAT2 NRP2 UBE4B
4 nervous system MP:0003631 9.5 CLU CNTF ERBB2 MAG MPZ NMNAT1

Drugs & Therapeutics for Wallerian Degeneration

Drugs for Wallerian Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved Phase 4 329-65-7 838
2
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
3
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
4
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
5 Adrenergic alpha-Agonists Phase 4
6 Respiratory System Agents Phase 4
7 Anti-Asthmatic Agents Phase 4
8 Anesthetics Phase 4
9 Adrenergic beta-Agonists Phase 4
10 Epinephryl borate Phase 4
11 Sympathomimetics Phase 4
12 Adrenergic Agents Phase 4
13 Mydriatics Phase 4
14 Neurotransmitter Agents Phase 4
15 Anesthetics, Local Phase 4
16 Bronchodilator Agents Phase 4
17 Adrenergic Agonists Phase 4
18 Vasoconstrictor Agents Phase 4
19 Narcotics
20 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intercostal Cryoneurolysis Following Traumatic Rib Fractures Enrolling by invitation NCT04198662 Phase 4 Intercostal nerve block ropivacaine with epinephrine
2 A Post-Market, Prospective, Randomized, Controlled Study to Evaluate the Iovera° Device Completed NCT03327220
3 Early Percutaneous Cryoablation for Pain Control After Rib Fractures Among Elderly Patients Not yet recruiting NCT04482582

Search NIH Clinical Center for Wallerian Degeneration

Genetic Tests for Wallerian Degeneration

Anatomical Context for Wallerian Degeneration

MalaCards organs/tissues related to Wallerian Degeneration:

40
Spinal Cord, Dorsal Root Ganglion, Cortex, Bone Marrow, Skeletal Muscle, Thalamus, Temporal Lobe

Publications for Wallerian Degeneration

Articles related to Wallerian Degeneration:

(show top 50) (show all 2205)
# Title Authors PMID Year
1
Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons. 54 61
20126265 2010
2
Protection of vincristine-induced neuropathy by WldS expression and the independence of the activity of Nmnat1. 54 61
17113230 2007
3
Sequential loss of myelin proteins during Wallerian degeneration in the human spinal cord. 61 54
15634734 2005
4
Glial cell responses, complement, and clusterin in the central nervous system following dorsal root transection. 54 61
9633807 1998
5
Central neuron-glial and glial-glial interactions following axon injury. 54 61
9602498 1998
6
Nerve expansion in nerve regeneration: effect of time on induction of ornithine decarboxylase and Schwann cell proliferation. 54 61
9324090 1997
7
Transient expression of the neurofilament proteins NF-L and NF-M by Schwann cells is regulated by axonal contact. 54 61
9373038 1997
8
Role of ornithine decarboxylase in proliferation of Schwann cells during Wallerian degeneration and its enhancement by nerve expansion. 54 61
7565936 1995
9
Temporal and spatial expression of ciliary neurotrophic factor after peripheral nerve injury. 61 54
8339774 1993
10
Expression of recombinant myelin-associated glycoprotein in primary Schwann cells promotes the initial investment of axons by myelinating Schwann cells. 54 61
1697293 1990
11
Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury. 61
33269753 2021
12
Emergence of the Wallerian degeneration pathway as a mechanism of secondary brain injury. 61
33229742 2021
13
Spinogenesis in spinal cord motor neurons following pharmacological lesions to the rat motor cortex. 61
29555297 2021
14
Clinical Features, Risk Factors, and Early Prognosis for Wallerian Degeneration in the Descending Pyramidal Tract after Acute Cerebral Infarction. 61
33253986 2021
15
A case of INI1-deficient tumor in the forearm successfully diagnosed as epithelioid malignant peripheral nerve sheath tumor: Intratumoral nerve fibers with Wallerian degeneration as a diagnostic aid. 61
33559197 2021
16
Phosphorylation at S548 as a Functional Switch of Sterile Alpha and TIR Motif-Containing 1 in Cerebral Ischemia/Reperfusion Injury in Rats. 61
32968873 2021
17
L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats In Vivo. 61
32993425 2021
18
Adipose tissue stem cells in peripheral nerve regeneration-In vitro and in vivo. 61
33070351 2021
19
A Reproducible New Model of Focal Ischemic Injury in the Marmoset Monkey: MRI and Behavioural Follow-Up. 61
32249405 2021
20
Protection against oxaliplatin-induced mechanical and thermal hypersensitivity in Sarm1-/- mice. 61
33460644 2021
21
Heat shock protein is a key therapeutic target for nerve repair in autoimmune peripheral neuropathy and severe peripheral nerve injury. 61
32858161 2021
22
Acute unilateral masseter muscle paralysis caused by pontine infarction. 61
33486342 2021
23
p53 is required for nuclear but not mitochondrial DNA damage-induced degeneration. 61
33473103 2021
24
Basic fibroblast growth factor accelerates myelin debris clearance through activating autophagy to facilitate early peripheral nerve regeneration. 61
33512767 2021
25
Interaction between Schwann cells and other cells during repair of peripheral nerve injury. 61
32788452 2021
26
Cisplatin induced neurotoxicity is mediated by Sarm1 and calpain activation. 61
33318563 2020
27
Autopsy of malignant paraganglioma causing compressive myelopathy due to vertebral metastases. 61
32885488 2020
28
Anti-hypernociceptive and anti-inflammatory effects of JM-20: A novel hybrid neuroprotective compound. 61
33096198 2020
29
Morphometric analysis of nerve fibers in neural leprosy. 61
33347629 2020
30
Polyethylene glycol-fusion repair of sciatic allografts in female rats achieves immunotolerance via attenuated innate and adaptive responses. 61
32931034 2020
31
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement. 61
33263277 2020
32
Diffuse axonal injury predicts neurodegeneration after moderate-severe traumatic brain injury. 61
33099608 2020
33
Hypertrophic olivary degeneration concomitant with bilateral middle cerebellar peduncles Wallerian degeneration following unilateral pontine infarction. 61
33160302 2020
34
In vivo imaging of injured cortical axons reveals a rapid onset form of Wallerian degeneration. 61
33208154 2020
35
Imaging resident and recruited macrophage contribution to Wallerian degeneration. 61
32648893 2020
36
Hedging against Neuropathic Pain: Role of Hedgehog Signaling in Pathological Nerve Healing. 61
33266112 2020
37
Direct and specific assessment of axonal injury and spinal cord microenvironments using diffusion correlation imaging. 61
32726643 2020
38
Peripheral Nerve Regeneration and Muscle Reinnervation. 61
33212795 2020
39
Wallerian degeneration in cervical spinal cord tracts is commonly seen in routine T2-weighted MRI after traumatic spinal cord injury and is associated with impairment in a retrospective study. 61
33125565 2020
40
Bilateral middle cerebellar peduncle lesions: Neuroimaging features and differential diagnoses. 61
32755074 2020
41
Neutrophil peptide-1 promotes the repair of sciatic nerve injury through the expression of proteins related to nerve regeneration. 61
33054687 2020
42
Collateral Sprouting of Peripheral Sensory Neurons Exhibits a Unique Transcriptomic Profile. 61
32696431 2020
43
Peripheral nerve regeneration following injury is altered in mice lacking P2X7 receptor. 61
33012061 2020
44
Identification of the first noncompetitive SARM1 inhibitors. 61
32828421 2020
45
Another umbrella murder? - A rare case of Minamata disease. 61
32323188 2020
46
Histological Assessment of Wallerian Degeneration of the Rat Tibial Nerve Following Crush and Transection Injuries. 61
32971546 2020
47
Corticospinal Wallerian Degeneration Before Myelination: A Case Report. 61
32406814 2020
48
Resveratrol regulates the recovery of rat sciatic nerve crush injury by promoting the autophagy of Schwann cells. 61
32531375 2020
49
Histologic Evaluation of Palmar Digital Nerves after Perineural Injection of 2% Ammonium Chloride in Miniature Horses. 61
32797793 2020
50
Augustus Volney Waller: physiologist who described distal degeneration of severed nerve fibres. 61
32990076 2020

Variations for Wallerian Degeneration

Expression for Wallerian Degeneration

Search GEO for disease gene expression data for Wallerian Degeneration.

Pathways for Wallerian Degeneration

Pathways related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 NRP2 NEFM MAG CLU
2 10.7 VEGFA NEFM CNTF

GO Terms for Wallerian Degeneration

Cellular components related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.1 VEGFA UBE4B UBA1 SIRT2 SARM1 PLEKHB1
2 axon GO:0030424 9.43 SEMA3A SARM1 NRP2 NMNAT2 NEFM CNTF
3 paranode region of axon GO:0033270 9.37 SIRT2 MAG
4 Schmidt-Lanterman incisure GO:0043220 9.32 SIRT2 MAG
5 neurofibrillary tangle GO:0097418 9.16 NEFM CLU
6 myelin sheath GO:0043209 8.92 SIRT2 MPZ MAG ERBB2

Biological processes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.12 VEGFA SEMA3A PLEKHB1 NRP2 ERBB2 CNTF
2 cell differentiation GO:0030154 10.09 VEGFA SIRT2 SEMA3A SARM1 NRP2 CNTF
3 positive regulation of MAPK cascade GO:0043410 9.81 VEGFA NMNAT1 ERBB2
4 neural crest cell migration GO:0001755 9.73 SEMA3F SEMA3A NRP2
5 negative chemotaxis GO:0050919 9.7 SEMA3F SEMA3A NRP2
6 nerve development GO:0021675 9.65 SEMA3F SEMA3A NRP2
7 regulation of neuron death GO:1901214 9.64 SARM1 CLU
8 regulation of postsynapse organization GO:0099175 9.63 SEMA3F NRP2
9 sympathetic ganglion development GO:0061549 9.63 SEMA3F SEMA3A NRP2
10 vascular endothelial growth factor signaling pathway GO:0038084 9.62 VEGFA NRP2
11 NAD metabolic process GO:0019674 9.62 NMNAT2 NMNAT1
12 NAD biosynthetic process GO:0009435 9.61 NMNAT2 NMNAT1
13 axon extension involved in axon guidance GO:0048846 9.61 SEMA3F SEMA3A NRP2
14 nucleotide biosynthetic process GO:0009165 9.6 NMNAT2 NMNAT1
15 pyridine nucleotide biosynthetic process GO:0019363 9.59 NMNAT2 NMNAT1
16 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.58 SEMA3F SEMA3A
17 axonogenesis involved in innervation GO:0060385 9.58 SEMA3A NPTX1
18 facial nerve structural organization GO:0021612 9.58 SEMA3F SEMA3A NRP2
19 branchiomotor neuron axon guidance GO:0021785 9.57 SEMA3F SEMA3A
20 nervous system development GO:0007399 9.56 VEGFA SIRT2 SEMA3A SARM1 NRP2 MAG
21 trigeminal ganglion development GO:0061551 9.55 SEMA3A NRP2
22 trigeminal nerve structural organization GO:0021637 9.54 SEMA3F SEMA3A
23 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.54 SEMA3F SEMA3A NRP2
24 gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 9.51 SEMA3A NRP2
25 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 9.5 SEMA3F SEMA3A NRP2
26 facioacoustic ganglion development GO:1903375 9.49 SEMA3A NRP2
27 sympathetic neuron projection guidance GO:0097491 9.43 SEMA3F SEMA3A NRP2
28 sympathetic neuron projection extension GO:0097490 9.33 SEMA3F SEMA3A NRP2
29 ventral trunk neural crest cell migration GO:0036486 8.8 SEMA3F SEMA3A NRP2

Molecular functions related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropilin binding GO:0038191 9.16 VEGFA SEMA3A
2 nicotinate-nucleotide adenylyltransferase activity GO:0004515 8.96 NMNAT2 NMNAT1
3 nicotinamide-nucleotide adenylyltransferase activity GO:0000309 8.62 NMNAT2 NMNAT1

Sources for Wallerian Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....