MCID: WLL004
MIFTS: 39

Wallerian Degeneration

Categories: Rare diseases

Aliases & Classifications for Wallerian Degeneration

MalaCards integrated aliases for Wallerian Degeneration:

Name: Wallerian Degeneration 53 55 73
Wallerian Degeneration of the Pyramidal Tract 53

Classifications:



External Ids:

UMLS 73 C0043020

Summaries for Wallerian Degeneration

MalaCards based summary : Wallerian Degeneration, also known as wallerian degeneration of the pyramidal tract, is related to neuronitis and cerebritis. An important gene associated with Wallerian Degeneration is NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Choline and Cytidine Diphosphate Choline have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and monocytes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Wallerian degeneration is a process that results when a nerve fiber is cut or crushed and the part of... more...

Related Diseases for Wallerian Degeneration

Graphical network of the top 20 diseases related to Wallerian Degeneration:



Diseases related to Wallerian Degeneration

Symptoms & Phenotypes for Wallerian Degeneration

GenomeRNAi Phenotypes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.55 UBE4B
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.55 CNTF
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.55 ERBB2 SEMA3A UBE4B CNTF
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.55 CNTF
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.55 UBE4B
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.55 UBE4B
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.55 CNTF
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.55 SEMA3A CNTF
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.55 SEMA3A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.55 SEMA3A
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.55 ERBB2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.55 ERBB2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.55 CNTF
14 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.35 ERBB2 NRP2 SEMA3A SEMA3F VEGFA

MGI Mouse Phenotypes related to Wallerian Degeneration:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 CLU CNTF ERBB2 MAG MPZ NMNAT1
2 cellular MP:0005384 10.1 UBE4B VEGFA CNTF ERBB2 MPZ NMNAT2
3 homeostasis/metabolism MP:0005376 10 CLU CNTF ERBB2 MAG MPZ NRP2
4 mortality/aging MP:0010768 9.93 ERBB2 MPZ NMNAT1 NMNAT2 NRP2 ODC1
5 muscle MP:0005369 9.5 CLU CNTF ERBB2 NMNAT2 NRP2 UBE4B
6 nervous system MP:0003631 9.5 SEMA3F SIRT2 UBE4B VEGFA CLU CNTF

Drugs & Therapeutics for Wallerian Degeneration

Drugs for Wallerian Degeneration (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Choline Approved, Nutraceutical Phase 4 62-49-7 305
2 Cytidine Diphosphate Choline Phase 4
3 Nootropic Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
2 Focal Cortical Atrophy After Myocardial Internal Capsule Completed NCT01862172 Not Applicable
3 Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain Recruiting NCT03327220 Not Applicable

Search NIH Clinical Center for Wallerian Degeneration

Genetic Tests for Wallerian Degeneration

Anatomical Context for Wallerian Degeneration

MalaCards organs/tissues related to Wallerian Degeneration:

41
Spinal Cord, Brain, Monocytes, Cortex, Bone, Bone Marrow, Pituitary

Publications for Wallerian Degeneration

Articles related to Wallerian Degeneration:

(show top 50) (show all 542)
# Title Authors Year
1
Bilateral wallerian degeneration of the middle cerebellar peduncles secondary to pontine infarction: A case series. ( 29627018 )
2018
2
Clinical and Radiological Features of Wallerian Degeneration of the Middle Cerebellar Peduncles Secondary to Pontine Infarction. ( 29521288 )
2018
3
Deficiency of adaptive immunity does not interfere with Wallerian degeneration. ( 28475650 )
2017
4
NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency InA Vivo. ( 28262487 )
2017
5
Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons. ( 28441556 )
2017
6
Teaching NeuroImages: Wallerian degeneration in evolving pediatric stroke. ( 28947589 )
2017
7
Neutrophils are critical for myelin removal in a peripheral nerve injury model of Wallerian degeneration. ( 28912156 )
2017
8
Microarray and qPCR Analyses of Wallerian Degeneration in Rat Sciatic Nerves. ( 28239339 )
2017
9
Wallerian degeneration of the bilateral middle cerebellar peduncles secondary to pontine infarction. ( 29285691 )
2017
10
Critical signaling pathways during Wallerian degeneration of peripheral nerve. ( 28761435 )
2017
11
GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. ( 28053206 )
2017
12
An assessment of the correlation between early postinfarction pyramidal tract Wallerian degeneration and nerve function recovery using diffusion tensor imaging. ( 28128402 )
2017
13
Death Receptor 6 Promotes Wallerian Degeneration in Peripheral Axons. ( 28285993 )
2017
14
Potential Use of 18F-THK5351 PET to Identify Wallerian Degeneration of the Pyramidal Tract Caused by Cerebral Infarction. ( 29076904 )
2017
15
Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis. ( 28302146 )
2017
16
Molecular mechanisms in the initiation phase of Wallerian degeneration. ( 27062141 )
2016
17
Neurographic course of Wallerian Degeneration after human peripheral nerve injury. ( 27875622 )
2016
18
An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2. ( 27732853 )
2016
19
SYSTEMIC TRANSPLANTATION OF BONE MARROW MONONUCLEAR CELLS PROMOTES AXONAL REGENERATION AND ANALGESIA IN A MODEL OF WALLERIAN DEGENERATION. ( 27607534 )
2016
20
Prolonged Wallerian degeneration in the corticospinal tract following external capsular hemorrhage. ( 27206896 )
2016
21
MRI findings in a case of spinal cord Wallerian degeneration following trauma. ( 27744468 )
2016
22
Polyethylene glycol-fusion retards Wallerian degeneration and rapidly restores behaviors lost after nerve severance. ( 27073362 )
2016
23
T2/Fluid Attenuation Inversion Recovery Hypointensity of Corticospinal Tracts due to Subacute Stage of Wallerian Degeneration. ( 28163512 )
2016
24
Ingenuity Pathway Analysis of Gene Expression Profiles in Distal Nerve Stump following Nerve Injury: Insights into Wallerian Degeneration. ( 27999531 )
2016
25
Toll-Like Receptor 3 Contributes to Wallerian Degeneration after Peripheral Nerve Injury. ( 27771719 )
2016
26
Autophagic myelin destruction by schwann cells during wallerian degeneration and segmental demyelination. ( 26712109 )
2016
27
Avian axons undergo Wallerian degeneration after injury and stress. ( 27614771 )
2016
28
Wallerian Degeneration in the Corticospinal Tract Following Tumefactive Demyelination: Conventional and Advanced Magnetic Resonance Imaging. ( 27417915 )
2016
29
Wallerian Degeneration Beyond the Corticospinal Tracts: Conventional and Advanced MRI Findings. ( 28072502 )
2016
30
Bilateral Wallerian Degeneration of the Pontocerebellar Tracts. ( 26171260 )
2015
31
TGF-I^1 is critical for Wallerian degeneration after rat sciatic nerve injury. ( 25451291 )
2015
32
Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury. ( 26419777 )
2015
33
Wallerian degeneration of the bilateral middle cerebellar peduncles. ( 25586535 )
2015
34
Early Wallerian degeneration in a neonate with middle carotid artery stroke. ( 25443582 )
2015
35
Wallerian Degeneration of the Superior Cerebellar Peduncle. ( 26457633 )
2015
36
Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca(2+) Influx but Only Modestly Influenced by Mitochondria. ( 26686637 )
2015
37
Longitudinal three-dimensional-T2WI-SPACE study on wallerian degeneration in cat corticospinal tract and underlying pathology changes. ( 26218829 )
2015
38
Wallerian degeneration of the pontocerebellar fibres secondary to pontine infarction. ( 26712359 )
2015
39
Differential gene expression in proximal and distal nerve segments of rats with sciatic nerve injury during Wallerian degeneration. ( 25206781 )
2014
40
Signaling mechanisms regulating Wallerian degeneration. ( 24907513 )
2014
41
Early corticospinal tract Wallerian degeneration versus mesencephalic substantia nigra degeneration secondary to striatal stroke. ( 24468328 )
2014
42
The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury. ( 25657736 )
2014
43
Keratan sulfate expression is associated with activation of a subpopulation of microglia/macrophages in Wallerian degeneration. ( 25046157 )
2014
44
Wallerian degeneration in the optic nerve stretch-injury model of TBI: a stereological analysis. ( 25333317 )
2014
45
Decline of compound muscle action potentials and statistical MUNEs during Wallerian degeneration. ( 25240559 )
2014
46
Resveratrol delays Wallerian degeneration in a NAD(+) and DBC1 dependent manner. ( 24252177 )
2014
47
Wallerian degeneration and recovery of motor nerves after multiple focused cold therapies. ( 24895229 )
2014
48
Wallerian degeneration: an emerging axon death pathway linking injury and disease. ( 24840802 )
2014
49
Progressive Wallerian Degeneration of the Corpus Callosal Splenium in a Patient with Alexia Without Agraphia: Advanced MR Findings. ( 25489886 )
2014
50
The Corpus Callosum Wallerian Degeneration in the Unilateral Brain Tumors: Evaluation with Diffusion Tensor Imaging (DTI). ( 23543618 )
2013

Variations for Wallerian Degeneration

Expression for Wallerian Degeneration

Search GEO for disease gene expression data for Wallerian Degeneration.

Pathways for Wallerian Degeneration

Pathways related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 CLU MAG NEFM NRP2
2 10.7 CNTF NEFM VEGFA

GO Terms for Wallerian Degeneration

Cellular components related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.62 CNTF NEFM SARM1 SEMA3A
2 paranode region of axon GO:0033270 9.26 MAG SIRT2
3 Schmidt-Lanterman incisure GO:0043220 9.16 MAG SIRT2
4 neurofibrillary tangle GO:0097418 8.96 CLU NEFM
5 myelin sheath GO:0043209 8.92 ERBB2 MAG MPZ SIRT2

Biological processes related to Wallerian Degeneration according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 regulation of neuron death GO:1901214 9.63 CLU SARM1
2 negative regulation of axon extension involved in axon guidance GO:0048843 9.62 SEMA3A SEMA3F
3 negative regulation of axon extension GO:0030517 9.62 MAG SEMA3A
4 motor neuron axon guidance GO:0008045 9.61 ERBB2 SEMA3A
5 NAD metabolic process GO:0019674 9.61 NMNAT1 NMNAT2
6 semaphorin-plexin signaling pathway GO:0071526 9.61 NRP2 SEMA3A SEMA3F
7 NAD biosynthetic process GO:0009435 9.6 NMNAT1 NMNAT2
8 growth GO:0040007 9.59 CNTF VEGFA
9 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.58 SEMA3A SEMA3F
10 pyridine nucleotide biosynthetic process GO:0019363 9.58 NMNAT1 NMNAT2
11 nerve development GO:0021675 9.58 NRP2 SEMA3A SEMA3F
12 cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742 9.57 MAG MPZ
13 facial nerve structural organization GO:0021612 9.56 SEMA3A SEMA3F
14 branchiomotor neuron axon guidance GO:0021785 9.55 SEMA3A SEMA3F
15 trigeminal nerve structural organization GO:0021637 9.54 SEMA3A SEMA3F
16 sympathetic ganglion development GO:0061549 9.54 NRP2 SEMA3A SEMA3F
17 axonogenesis involved in innervation GO:0060385 9.52 NPTX1 SEMA3A
18 axon extension involved in axon guidance GO:0048846 9.5 NRP2 SEMA3A SEMA3F
19 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.49 SEMA3A SEMA3F
20 de novo NAD biosynthetic process from aspartate GO:0034628 9.48 NMNAT1 NMNAT2
21 ventral trunk neural crest cell migration GO:0036486 9.46 SEMA3A SEMA3F
22 sympathetic neuron projection guidance GO:0097491 9.43 NRP2 SEMA3A SEMA3F
23 sympathetic neuron projection extension GO:0097490 9.33 NRP2 SEMA3A SEMA3F
24 nervous system development GO:0007399 9.23 CNTF ERBB2 MAG NRP2 SARM1 SEMA3A
25 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 9.13 NRP2 SEMA3A SEMA3F
26 cell differentiation GO:0030154 10.05 CNTF ERBB2 NRP2 SARM1 SEMA3A SIRT2

Molecular functions related to Wallerian Degeneration according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemorepellent activity GO:0045499 9.32 SEMA3A SEMA3F
2 semaphorin receptor binding GO:0030215 9.26 SEMA3A SEMA3F
3 neuropilin binding GO:0038191 9.16 SEMA3A SEMA3F
4 nicotinate-nucleotide adenylyltransferase activity GO:0004515 8.96 NMNAT1 NMNAT2
5 nicotinamide-nucleotide adenylyltransferase activity GO:0000309 8.62 NMNAT1 NMNAT2

Sources for Wallerian Degeneration

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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