WARFS
MCID: WRF006
MIFTS: 22

Warfarin Sensitivity, X-Linked (WARFS)

Categories: Blood diseases, Cardiovascular diseases, Genetic diseases, Metabolic diseases

Aliases & Classifications for Warfarin Sensitivity, X-Linked

MalaCards integrated aliases for Warfarin Sensitivity, X-Linked:

Name: Warfarin Sensitivity, X-Linked 57 73 6
Coumarin Sensitivity, X-Linked 57 73
X-Linked Warfarin Sensitivity 12
Warfarin Sensitivity 57
Warfs 73

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
x-linked


Classifications:



External Ids:

Disease Ontology 12 DOID:0080839
OMIM® 57 301052
MeSH 44 D004351

Summaries for Warfarin Sensitivity, X-Linked

UniProtKB/Swiss-Prot : 73 Warfarin sensitivity, X-linked: A condition characterized by sensitivity to warfarin, a drugs used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. Warfarin sensitive individuals develop bleeding complications when they are given warfarin within the therapeutic ranges.

MalaCards based summary : Warfarin Sensitivity, X-Linked, also known as coumarin sensitivity, x-linked, is related to coumarin resistance and thrombophilia due to thrombin defect. An important gene associated with Warfarin Sensitivity, X-Linked is F9 (Coagulation Factor IX). The drugs Warfarin and Anticoagulants have been mentioned in the context of this disorder.

Disease Ontology : 12 An inherited metabolic disorder that is characterized by bleeding complications when given warfarin for anticoagulation and that has material basis in variation in the F9 gene on chromosome Xq27.

OMIM® : 57 Warfarin is a widely prescribed anticoagulant for the prevention of thromboembolic diseases for subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. The dose requirement is highly variable, both interindividually and interethnically (Yuan et al., 2005). (301052) (Updated 05-Mar-2021)

Related Diseases for Warfarin Sensitivity, X-Linked

Diseases related to Warfarin Sensitivity, X-Linked via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 coumarin resistance 11.8
2 thrombophilia due to thrombin defect 10.0
3 pulmonary disease, chronic obstructive 9.8
4 disseminated intravascular coagulation 9.8
5 vitamin k deficiency bleeding 9.8
6 heart disease 9.8
7 hepatitis c 9.8
8 hepatitis 9.8
9 merkel cell carcinoma 9.8
10 congestive heart failure 9.8

Graphical network of the top 20 diseases related to Warfarin Sensitivity, X-Linked:



Diseases related to Warfarin Sensitivity, X-Linked

Symptoms & Phenotypes for Warfarin Sensitivity, X-Linked

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Hematology:
warfarin resistance
warfarin sensitivity

Laboratory Abnormalities:
warfarin resistance
warfarin sensitivity

Clinical features from OMIM®:

301052 (Updated 05-Mar-2021)

Drugs & Therapeutics for Warfarin Sensitivity, X-Linked

Drugs for Warfarin Sensitivity, X-Linked (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved 81-81-2 6691 54678486
2 Anticoagulants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 in Typical Community Practice Settings Completed NCT00830570

Search NIH Clinical Center for Warfarin Sensitivity, X-Linked

Genetic Tests for Warfarin Sensitivity, X-Linked

Anatomical Context for Warfarin Sensitivity, X-Linked

Publications for Warfarin Sensitivity, X-Linked

Articles related to Warfarin Sensitivity, X-Linked:

# Title Authors PMID Year
1
Missense mutations at ALA-10 in the factor IX propeptide: an insignificant variant in normal life but a decisive cause of bleeding during oral anticoagulant therapy. 57 6
9233593 1997
2
A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism. 6 57
8833911 1996
3
Variants in FIX propeptide associated with vitamin K antagonist hypersensitivity: functional analysis and additional data confirming the common founder mutations. 57
29450643 2018
4
A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity. 57
15888487 2005
5
Genetic predisposition to bleeding during oral anticoagulant therapy: evidence for common founder mutations (FIXVal-10 and FIXThr-10) and an independent CpG hotspot mutation (FIXThr-10). 57
11307814 2001
6
World Alliance for Risk Factor Surveillance White Paper on Surveillance and Health Promotion. 61
29546092 2015
7
What Could Be Future Scenarios?-Lessons from the History of Public Health Surveillance for the Future: --A keynote address presented at the 8th World Alliance for Risk Factor Surveillance (WARFS) Global Conference on October 30, 2013, Beijing, China. 61
29546093 2015
8
Abstracts presented at the 7th World Alliance for Risk Factor Surveillance (WARFS) Global Conference. October 16-19, 2011. Toronto, Ontario, Canada. 61
22284719 2012
9
Health promotion and surveillance: the establishment of an IUHPE global working group. 61
20028670 2009

Variations for Warfarin Sensitivity, X-Linked

ClinVar genetic disease variations for Warfarin Sensitivity, X-Linked:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 F9 F9, ALA-10THR SNV Pathogenic 10659
2 F9 F9, ALA-10VAL Variation Pathogenic 10661

Expression for Warfarin Sensitivity, X-Linked

Search GEO for disease gene expression data for Warfarin Sensitivity, X-Linked.

Pathways for Warfarin Sensitivity, X-Linked

GO Terms for Warfarin Sensitivity, X-Linked

Sources for Warfarin Sensitivity, X-Linked

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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