MCID: WRM004
MIFTS: 20

Warm Antibody Hemolytic Anemia

Categories: Blood diseases, Immune diseases, Rare diseases

Aliases & Classifications for Warm Antibody Hemolytic Anemia

MalaCards integrated aliases for Warm Antibody Hemolytic Anemia:

Name: Warm Antibody Hemolytic Anemia 52
Warm Antibody Autoimmune Hemolytic Anemia 52
Warm-Reacting-Antibody Hemolytic Anemia 52
Warm Autoimmune Hemolytic Anemia 71
Warm Antibody Aiha 52

Classifications:



External Ids:

UMLS 71 C0272118

Summaries for Warm Antibody Hemolytic Anemia

NIH Rare Diseases : 52 Warm antibody hemolytic anemia is the most common form of autoimmune hemolytic anemia . It is defined by the presence of autoantibodies that attach to and destroy red blood cells at temperatures equal to or greater than normal body temperature. The disease is characterized by symptoms related to anemia , including fatigue, difficulty breathing , jaundice and dark urine. In severe disease, fever, chest pain, syncope or heart failure may occur. Hemolysis (the breakdown of red blood cells ) occurs mainly in the spleen, so mild splenomegaly is relatively common. Treatment typically involves a corticosteroid like prednisone . In cases that don't respond to treatment, splenectomy may be considered. Chronic and severe disease may be treated with Rituximab or immunosuppressive medications.

MalaCards based summary : Warm Antibody Hemolytic Anemia, also known as warm antibody autoimmune hemolytic anemia, is related to anemia, autoimmune hemolytic and hemolytic anemia. The drugs Immunologic Factors and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include spleen, heart and kidney.

Wikipedia : 74 Warm antibody autoimmune hemolytic anemia (WAIHA) is the most common form of autoimmune haemolytic... more...

Related Diseases for Warm Antibody Hemolytic Anemia

Graphical network of the top 20 diseases related to Warm Antibody Hemolytic Anemia:



Diseases related to Warm Antibody Hemolytic Anemia

Symptoms & Phenotypes for Warm Antibody Hemolytic Anemia

Drugs & Therapeutics for Warm Antibody Hemolytic Anemia

Drugs for Warm Antibody Hemolytic Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 3
2 Antirheumatic Agents Phase 3
3 Antineoplastic Agents, Immunological Phase 3
4 Autoantibodies Phase 3
5
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
6
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
7
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
8 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
9
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
10
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
11
Aldesleukin Approved Phase 1, Phase 2 85898-30-2, 110942-02-4
12
Lactitol Approved, Investigational Phase 1, Phase 2 585-88-6, 585-86-4 493591
13
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
14
rituximab Approved Phase 2 174722-31-7 10201696
15
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
16 Methylprednisolone Acetate Phase 2
17 Adjuvants, Immunologic Phase 2
18 Anthelmintics Phase 2
19 Anti-Infective Agents Phase 2
20 Antiparasitic Agents Phase 2
21 Hormones Phase 2
22 Hormone Antagonists Phase 2
23 glucocorticoids Phase 2
24 Antineoplastic Agents, Hormonal Phase 2
25 Anti-Inflammatory Agents Phase 2
26 Analgesics, Non-Narcotic Phase 1, Phase 2
27 Analgesics Phase 1, Phase 2
28 Interleukin-2 Phase 1, Phase 2
29 Antibodies, Monoclonal Phase 2
30 Agglutinins Phase 2
31 Complement System Proteins Phase 2
32 Antibodies Phase 2
33 Immunoglobulins Phase 2
34 Immunoglobulins, Intravenous Phase 2
35 Immunoglobulin G Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Rituximab in Adult's Warm Auto-Immune Hemolytic Anemia : a Phase III, Double-bind, Randomised Placebo-controlled Trial Completed NCT01181154 Phase 3 rituximab (Mabthera®);Placebo
2 A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia Recruiting NCT03764618 Phase 3 Fostamatinib disodium;Placebo
3 A Phase 3 Open Label Extension Study of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia Active, not recruiting NCT04138927 Phase 3 Fostamatinib disodium
4 Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia: A Multicenter, Randomized, Double-blind, Placebo-controlled Study Suspended NCT04119050 Phase 2, Phase 3 M281;Placebo
5 Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia. Unknown status NCT01579110 Phase 2 levamisole;Prednisone
6 A Single-Arm Pilot Study With Low-Dose Rituximab Plus Standard Oral Prednisone In Idiopathic Autoimmune Hemolytic Anemia Completed NCT01345708 Phase 2 prednisone, low dose rituximab
7 " Anemil Trial ": Phase I/II Clinical Trial Evaluating the Interest of Interleukine-2 for Patients With Active Warm Hemolytic Anemia Resistant to Conventional Treatment Completed NCT02389231 Phase 1, Phase 2 Interleukine-2
8 An Open, One-arm, Prospective Study of a Single Dose Anti-CD20 Monoclonal Antibody Combined With Bortezomib for Treatment of Relapsed Refractory Autoimmune Hemolytic Anemia Recruiting NCT04083014 Phase 2 combination of a single dose anti-CD20 antibody and bortezomib
9 A Phase 2, Multi-Center, Open Label, Simon Two-Stage Study to Evaluate the Safety and Efficacy of Fostamatinib Disodium in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia Active, not recruiting NCT02612558 Phase 2 Fostamatinib 150 mg bid
10 An Open Label, Prospective, Study to Assess the Safety, Tolerability, Efficacy and Pharmacokinetics of APL-2 in Patients With Warm Type Autoimmune Hemolytic Anemia (wAIHA) or Cold Agglutinin Disease (CAD) Active, not recruiting NCT03226678 Phase 2 APL-2
11 Ibrutinib in Steroid Refractory Autoimmune Hemolytic Anemia: ELaboration of Treatment Approach Active, not recruiting NCT03827603 Phase 2 Ibrutinib
12 A Phase 2, Multicenter, Non-Randomized, Open-Label Study of RVT-1401 for the Treatment of Patients With Warm Autoimmune Hemolytic Anemia Not yet recruiting NCT04253236 Phase 2 RVT-1401 680 mg/weekly;RVT-1401 340 mg/weekly
13 A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Study of ALXN1830 in Patients With Warm Autoimmune Hemolytic Anemia Suspended NCT04256148 Phase 2
14 A Phase 1B/2, Multicenter, Open-Label, Safety, Tolerability, and Activity Study of SYNT001 in Patients With Warm Autoimmune Hemolytic Anemia (WAIHA) Terminated NCT03075878 Phase 1, Phase 2 ALXN1830
15 A Prospective Open-label Trial to Assess the Efficacy and Safety of Ixazomib and Dexamethasone in Patients With Refractory Autoimmune Cytopenia Withdrawn NCT03965624 Phase 2 Ninlaro
16 One Year Hospital Data Patients With Autoimmune Hemolytic Anaemia in Assiut University Hospital - Clinical Hematology Unit Unknown status NCT03269292

Search NIH Clinical Center for Warm Antibody Hemolytic Anemia

Genetic Tests for Warm Antibody Hemolytic Anemia

Anatomical Context for Warm Antibody Hemolytic Anemia

MalaCards organs/tissues related to Warm Antibody Hemolytic Anemia:

40
Spleen, Heart, Kidney, Testes

Publications for Warm Antibody Hemolytic Anemia

Articles related to Warm Antibody Hemolytic Anemia:

# Title Authors PMID Year
1
A Case of Pregnancy Complicated with Evans Syndrome with Sequential Development of Autoimmune Warm Antibody Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura. 61
30733882 2019
2
Warm antibody hemolytic anemia-a rare presentation of neonatal lupus. 61
27516434 2017
3
The role of rituximab in adults with warm antibody autoimmune hemolytic anemia. 61
25827833 2015
4
Splenic infarction, warm autoimmune hemolytic anemia and antiphospholipid antibodies in a patient with infectious mononucleosis. 61
22407854 2012
5
Induction of heme oxygenase-1 and ferritin in the kidney in warm antibody hemolytic anemia. 61
18805612 2008
6
Dydrogesterone-induced hepatitis and autoimmune hemolytic anemia. 61
15264122 2004
7
Anti-CD20 therapy for chronic lymphocytic leukemia-associated autoimmune diseases. 61
14738149 2003
8
Warm antibody hemolytic anemia; prolonged remission despite persistent positive Coombs test. 61
5310347 1968

Variations for Warm Antibody Hemolytic Anemia

Expression for Warm Antibody Hemolytic Anemia

Search GEO for disease gene expression data for Warm Antibody Hemolytic Anemia.

Pathways for Warm Antibody Hemolytic Anemia

GO Terms for Warm Antibody Hemolytic Anemia

Sources for Warm Antibody Hemolytic Anemia

3 CDC
7 CNVD
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11 DGIdb
17 EFO
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19 FMA
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30 HMDB
31 HPO
32 ICD10
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48 NCI
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50 NDF-RT
53 NINDS
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56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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