WABS
MCID: WRS003
MIFTS: 12

Warsaw Syndrome (WABS)

Aliases & Classifications for Warsaw Syndrome

MalaCards integrated aliases for Warsaw Syndrome:

Name: Warsaw Syndrome 24
Warsaw Breakage Syndrome 24
Wabs 24

Summaries for Warsaw Syndrome

MalaCards based summary : Warsaw Syndrome, also known as warsaw breakage syndrome, is related to fanconi anemia, complementation group a and aphasia. An important gene associated with Warsaw Syndrome is DDX11 (DEAD/H-Box Helicase 11). Affiliated tissues include skin.

GeneReviews: NBK541972

Related Diseases for Warsaw Syndrome

Graphical network of the top 20 diseases related to Warsaw Syndrome:



Diseases related to Warsaw Syndrome

Symptoms & Phenotypes for Warsaw Syndrome

Drugs & Therapeutics for Warsaw Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Role of Bacterial Toxins in Human Skin Disease Recruiting NCT02910791

Search NIH Clinical Center for Warsaw Syndrome

Genetic Tests for Warsaw Syndrome

Anatomical Context for Warsaw Syndrome

MalaCards organs/tissues related to Warsaw Syndrome:

41
Skin

Publications for Warsaw Syndrome

Articles related to Warsaw Syndrome:

(show all 32)
# Title Authors PMID Year
1
Two further patients with Warsaw breakage syndrome. Is a mild phenotype possible? 38 4
30924321 2019
2
Warsaw breakage syndrome: Further clinical and genetic delineation. 38 4
30216658 2018
3
Clinical Report: Warsaw Breakage Syndrome with small radii and fibulae. 38 4
28960803 2017
4
Warsaw Breakage Syndrome--A further report, emphasising cutaneous findings. 38 4
25701697 2015
5
Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome. 38 4
24487782 2014
6
Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome. 38 4
23033317 2013
7
Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1. 38 4
20137776 2010
8
Management of Cochlear Nerve Hypoplasia and Aplasia. 4
29794457 2018
9
Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. 4
17611414 2007
10
The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. 4
17105772 2006
11
Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase. 4
10648783 2000
12
Study of carrier frequency of Warsaw breakage syndrome in the Ashkenazi Jewish population and presentation of two cases. 38
31287223 2019
13
Warsaw Syndrome 38
31169992 2019
14
Molecular and Cellular Functions of the Warsaw Breakage Syndrome DNA Helicase DDX11. 38
30469382 2018
15
Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion. 38
30303954 2018
16
Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites. 38
30061412 2018
17
How many roads lead to cohesinopathies? 38
28422453 2017
18
Exploring and exploiting the systemic effects of deregulated replication licensing. 38
26707000 2016
19
Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway. 38
26503245 2016
20
Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function. 38
26423134 2015
21
The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development. 38
26089203 2015
22
DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity. 38
25583207 2015
23
A distinct triplex DNA unwinding activity of ChlR1 helicase. 38
25561740 2015
24
The Q Motif Is Involved in DNA Binding but Not ATP Binding in ChlR1 Helicase. 38
26474416 2015
25
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. 38
23935105 2013
26
Roles of ChlR1 DNA helicase in replication recovery from DNA damage. 38
23797032 2013
27
Disease-causing missense mutations in human DNA helicase disorders. 38
23276657 2013
28
DNA helicases associated with genetic instability, cancer, and aging. 38
23161009 2013
29
Chl1 DNA helicase regulates Scc2 deposition specifically during DNA-replication in Saccharomyces cerevisiae. 38
24086532 2013
30
Biochemical characterization of Warsaw breakage syndrome helicase. 38
22102414 2012
31
Mammalian ChlR1 has a role in heterochromatin organization. 38
21854770 2011
32
Diagnostic Overlap between Fanconi Anemia and the Cohesinopathies: Roberts Syndrome and Warsaw Breakage Syndrome. 38
21490908 2010

Variations for Warsaw Syndrome

Expression for Warsaw Syndrome

Search GEO for disease gene expression data for Warsaw Syndrome.

Pathways for Warsaw Syndrome

GO Terms for Warsaw Syndrome

Sources for Warsaw Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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