WABS
MCID: WRS003
MIFTS: 12

Warsaw Syndrome (WABS)

Aliases & Classifications for Warsaw Syndrome

MalaCards integrated aliases for Warsaw Syndrome:

Name: Warsaw Syndrome 24
Warsaw Breakage Syndrome 24
Wabs 24

Summaries for Warsaw Syndrome

MalaCards based summary : Warsaw Syndrome, also known as warsaw breakage syndrome, is related to fanconi anemia, complementation group a and aphasia. An important gene associated with Warsaw Syndrome is DDX11 (DEAD/H-Box Helicase 11). Affiliated tissues include skin.

GeneReviews: NBK541972

Related Diseases for Warsaw Syndrome

Graphical network of the top 20 diseases related to Warsaw Syndrome:



Diseases related to Warsaw Syndrome

Symptoms & Phenotypes for Warsaw Syndrome

Drugs & Therapeutics for Warsaw Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Role of Bacterial Toxins in Human Skin Disease Recruiting NCT02910791

Search NIH Clinical Center for Warsaw Syndrome

Genetic Tests for Warsaw Syndrome

Anatomical Context for Warsaw Syndrome

MalaCards organs/tissues related to Warsaw Syndrome:

40
Skin

Publications for Warsaw Syndrome

Articles related to Warsaw Syndrome:

(show all 35)
# Title Authors PMID Year
1
Two further patients with Warsaw breakage syndrome. Is a mild phenotype possible? 61 24
30924321 2019
2
Warsaw breakage syndrome: Further clinical and genetic delineation. 61 24
30216658 2018
3
Clinical Report: Warsaw Breakage Syndrome with small radii and fibulae. 61 24
28960803 2017
4
Warsaw Breakage Syndrome--A further report, emphasising cutaneous findings. 61 24
25701697 2015
5
Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome. 61 24
24487782 2014
6
Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome. 61 24
23033317 2013
7
Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1. 61 24
20137776 2010
8
Management of Cochlear Nerve Hypoplasia and Aplasia. 24
29794457 2018
9
Loss of ChlR1 helicase in mouse causes lethality due to the accumulation of aneuploid cells generated by cohesion defects and placental malformation. 24
17611414 2007
10
The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. 24
17105772 2006
11
Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase. 24
10648783 2000
12
Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2. 61
31935221 2020
13
The expanding phenotypes of cohesinopathies: one ring to rule them all! 61
31516082 2019
14
Study of carrier frequency of Warsaw breakage syndrome in the Ashkenazi Jewish population and presentation of two cases. 61
31287223 2019
15
Warsaw Syndrome 61
31169992 2019
16
Spotlight on Warsaw Breakage Syndrome. 61
31824187 2019
17
Molecular and Cellular Functions of the Warsaw Breakage Syndrome DNA Helicase DDX11. 61
30469382 2018
18
Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion. 61
30303954 2018
19
Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites. 61
30061412 2018
20
How many roads lead to cohesinopathies? 61
28422453 2017
21
Exploring and exploiting the systemic effects of deregulated replication licensing. 61
26707000 2016
22
Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway. 61
26503245 2016
23
Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function. 61
26423134 2015
24
The Warsaw breakage syndrome-related protein DDX11 is required for ribosomal RNA synthesis and embryonic development. 61
26089203 2015
25
A distinct triplex DNA unwinding activity of ChlR1 helicase. 61
25561740 2015
26
DNA helicases FANCM and DDX11 are determinants of PARP inhibitor sensitivity. 61
25583207 2015
27
The Q Motif Is Involved in DNA Binding but Not ATP Binding in ChlR1 Helicase. 61
26474416 2015
28
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. 61
23935105 2013
29
Roles of ChlR1 DNA helicase in replication recovery from DNA damage. 61
23797032 2013
30
Disease-causing missense mutations in human DNA helicase disorders. 61
23276657 2013
31
DNA helicases associated with genetic instability, cancer, and aging. 61
23161009 2013
32
Chl1 DNA helicase regulates Scc2 deposition specifically during DNA-replication in Saccharomyces cerevisiae. 61
24086532 2013
33
Biochemical characterization of Warsaw breakage syndrome helicase. 61
22102414 2012
34
Mammalian ChlR1 has a role in heterochromatin organization. 61
21854770 2011
35
Diagnostic Overlap between Fanconi Anemia and the Cohesinopathies: Roberts Syndrome and Warsaw Breakage Syndrome. 61
21490908 2010

Variations for Warsaw Syndrome

Expression for Warsaw Syndrome

Search GEO for disease gene expression data for Warsaw Syndrome.

Pathways for Warsaw Syndrome

GO Terms for Warsaw Syndrome

Sources for Warsaw Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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