MCID: WRT003
MIFTS: 26

Warthin Tumor

Categories: Rare diseases

Aliases & Classifications for Warthin Tumor

MalaCards integrated aliases for Warthin Tumor:

Name: Warthin Tumor 20 17
Adenolymphoma 70

Classifications:



External Ids:

UMLS 70 C0001429

Summaries for Warthin Tumor

GARD : 20 Warthin tumor is a benign tumor of the salivary gland. The first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. Warthin tumors may increase in size over time, but few become cancerous. Though the cause is currently unknown, smoking is believed to increase the chance of developing Warthin tumor. Treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time.

MalaCards based summary : Warthin Tumor, also known as adenolymphoma, is related to pleomorphic adenoma and mucoepidermoid carcinoma. An important gene associated with Warthin Tumor is CRTC1 (CREB Regulated Transcription Coactivator 1), and among its related pathways/superpathways are Glucose / Energy Metabolism and Human T-cell leukemia virus 1 infection. Affiliated tissues include salivary gland, lymph node and tongue.

Related Diseases for Warthin Tumor

Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 pleomorphic adenoma 30.0 MAML2 KRT7 CRTC1
2 mucoepidermoid carcinoma 29.5 MAML2 KRT7 CRTC3 CRTC1
3 salivary gland disease 28.7 MAML2 KRT7 CRTC3 CRTC1
4 cystadenoma 10.5
5 thyroid carcinoma 10.3
6 adenoma 10.2
7 thyroid cancer, nonmedullary, 1 10.1
8 lymphoma 10.1
9 thyroiditis 10.1
10 leukemia, chronic lymphocytic 10.1
11 lymphoma, hodgkin, classic 10.1
12 follicular lymphoma 10.1
13 necrotizing sialometaplasia 10.1
14 squamous cell carcinoma 10.1
15 acinar cell carcinoma 10.1
16 papillary carcinoma 10.1
17 lipoadenoma 9.9 KRT7 CRTC1
18 hashimoto thyroiditis 9.9
19 prostate cancer 9.9
20 sarcoidosis 1 9.9
21 graves disease 1 9.9
22 langerhans cell histiocytosis 9.9
23 lymphoma, non-hodgkin, familial 9.9
24 disease by infectious agent 9.9
25 exanthem 9.9
26 diffuse large b-cell lymphoma 9.9
27 mantle cell lymphoma 9.9
28 peripheral t-cell lymphoma 9.9
29 ductal carcinoma in situ 9.9
30 igg4-related disease 9.9
31 tongue carcinoma 9.9
32 parotitis 9.9
33 sialadenitis 9.9
34 brucellosis 9.9
35 arteriovenous malformation 9.9
36 goiter 9.9
37 graves' disease 9.9
38 leukemia 9.9
39 neuroendocrine tumor 9.9
40 islet cell tumor 9.9
41 neuroendocrine carcinoma 9.9
42 mandibular cancer 9.9
43 myoepithelioma 9.9
44 pulmonary tuberculosis 9.9
45 adenocarcinoma 9.9
46 histiocytosis 9.9
47 cll/sll 9.9
48 b-cell lymphoma 9.9
49 supraglottis neoplasm 9.9
50 actinomycosis 9.9

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to Warthin Tumor

Symptoms & Phenotypes for Warthin Tumor

Drugs & Therapeutics for Warthin Tumor

Search Clinical Trials , NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

Anatomical Context for Warthin Tumor

MalaCards organs/tissues related to Warthin Tumor:

40
Salivary Gland, Lymph Node, Tongue, Thyroid, Breast, Bone Marrow, Pancreas

Publications for Warthin Tumor

Articles related to Warthin Tumor:

(show top 50) (show all 513)
# Title Authors PMID Year
1
Warthin tumor arising from the minor salivary gland. 61 20
22976673 2012
2
[Immunohistological investigation of epithelial components of adenolymphoma of the parotid gland]. 54 61
1376356 1992
3
Radiomic model for differentiating parotid pleomorphic adenoma from parotid adenolymphoma based on MRI images. 61
33743615 2021
4
Clinicopathological features of incidental parotid lesions. 61
33757536 2021
5
Texture analysis in the characterization of parotid salivary gland lesions: A study on MR diffusion weighted imaging. 61
33453571 2021
6
Surgeon-performed ultrasound with fine-needle aspiration biopsy for the diagnosis of parotid gland tumors. 61
33547678 2021
7
Warthin Tumor Incidentally Detected on PET/CT Showing Both 68Ga-DOTANOC and 18F-FDG Uptake. 61
32956121 2021
8
Classification of parotid gland tumors by using multimodal MRI and deep learning. 61
32886955 2021
9
Assessing the diagnostic accuracy for pleomorphic adenoma and Warthin tumor by employing the Milan System for Reporting Salivary Gland Cytopathology: An international, multi-institutional study. 61
32767837 2021
10
Efficacy of computed tomography features in the differentiation of basal cell adenoma and Warthin tumor in the parotid gland. 61
33478930 2021
11
Warthin Tumor of the Caruncle: A Rare Case Report and Review of the Literature. 61
33481538 2021
12
Sebaceous Lymphadenoma: Radiology-Pathology Correlation. 61
33398686 2021
13
Pediatric Warthin-like Mucoepidermoid Carcinoma: Report of Two Cases with One Persistent/Recurrent as Conventional Mucoepidermoid Carcinoma. 61
32221865 2020
14
Reply to Assessing the diagnostic accuracy for pleomorphic adenoma and Warthin tumor by employing the Milan System for Reporting Salivary Gland Cytopathology: An international, multi-institutional study. 61
33259142 2020
15
Assessing the diagnostic accuracy for pleomorphic adenoma and Warthin tumor by employing the Milan System for Reporting Salivary Gland Cytopathology: An international, multi-institutional study. 61
33259150 2020
16
Crystalloids in FNA specimens of salivary gland lesions: A retrospective study in a single large institute. 61
33296146 2020
17
Prevalence of Lymphoid Neoplasia in a Retrospective Analysis of Warthin Tumor: A Single Institution Experience. 61
32328910 2020
18
Differentiation of salivary gland tumors through tumor heterogeneity: a comparison between pleomorphic adenoma and Warthin tumor using CT texture analysis. 61
32621023 2020
19
Can Magnetic Resonance Radiomics Analysis Discriminate Parotid Gland Tumors? A Pilot Study. 61
33153140 2020
20
[Expression of NR4A3/NOR-1 in acinic cell carcinoma of the salivary gland]. 61
33152819 2020
21
Added value of susceptibility-weighted imaging to diffusion-weighted imaging in the characterization of parotid gland tumors. 61
32328768 2020
22
Expression of TdT in Myoepithelial Cells: Investigation in Breasts, Sweat Glands, and Salivary Lesions Emphasizing the Never-Documented Immunohistochemical Findings. 61
32362207 2020
23
Ulcerative Warthin Tumor: A Case Report and Review of the Literature. 61
32931334 2020
24
[Application of retroauricular sulcus incision in surgery of parotid gland tumor]. 61
32911889 2020
25
Low Molecular Weight Cytokeratin Immunohistochemistry Reveals That Most Salivary Gland Warthin Tumors and Lymphadenomas Arise in Intraparotid Lymph Nodes. 61
32865726 2020
26
Oncocytic features in salivary duct carcinoma, a potential pitfall for misdiagnosis as Warthin tumor in fine needle aspiration specimens: A cytomorphologic analysis of 14 cases. 61
32271502 2020
27
Warthin's tumour seems to be the most common benign neoplasm of the parotid gland in Germany. 61
32189070 2020
28
[Diagnostic value of high-resolution ultrasonography in parotid space occupying lesions]. 61
32791640 2020
29
Diagnostic Value of Superb Microvascular Imaging in Parotid Tumors. 61
32507848 2020
30
Incidence of Non-Salivary Gland Neoplasms in Patients with Warthin Tumor: A Study of 73 Cases. 61
31228167 2020
31
Follicular Lymphoma Diagnosed in Warthin Tumor: A Case Report and Review of the Literature. 61
31183747 2020
32
Xanthogranulomatous Sialadenitis, an Uncommon Reactive Change is Often Associated with Warthin's Tumor. 61
31473936 2020
33
Synchronous Oncocytic Papillary Cystadenoma and Warthin Tumor of the Parotid Gland. 61
31698976 2020
34
The significance of mucinous metaplasia in Warthin tumor: a frequent occurrence and potential pitfall. 61
32223989 2020
35
Imaging quality of PROPELLER diffusion-weighted MR imaging and its diagnostic performance in distinguishing pleomorphic adenomas from Warthin tumors of the parotid gland. 61
32124504 2020
36
Improving the diagnosis of common parotid tumors via the combination of CT image biomarkers and clinical parameters. 61
32293304 2020
37
Aberrant Expression of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) in Warthin Tumors. 61
32365590 2020
38
Incidental 18F-Fluciclovine Uptake in a Warthin Tumor of the Parotid Gland in a Patient Undergoing PET/CT Imaging for Biochemical Recurrent Prostate Cancer. 61
31977491 2020
39
Own experience in the treatment of major salivary gland tumors. 61
32398385 2020
40
Cytomorphological findings in diagnosis of Warthin tumor 61
31769640 2020
41
Salivary gland tumors: A 15-year experience of a university hospital in Turkey. 61
33043262 2020
42
Incipient Warthin tumor of intraparotid lymph node in a patient with squamous cell carcinoma of the external auditory canal: An incidental finding. 61
33041588 2020
43
[Clinical value of quantitative parameters by spectral CT in parotid gland tumor]. 61
31875442 2019
44
Juvenile sclerosing polycystic adenosis cytologically mimicking Warthin tumor. 61
31329351 2019
45
Evaluation of Outcomes following Radiofrequency Ablation for Treatment of Parotid Tail Warthin Tumors. 61
31471194 2019
46
Giant Warthin's Tumour of the Parotid Gland: A Rare Case Report. 61
31742077 2019
47
Bilateral Warthin tumor with a fibrous variant of chronic lymphocytic thyroiditis misdiagnosed as well-differentiated thyroid cancer with lymph node metastasis. 61
31389402 2019
48
Risk stratification of fine-needle aspiration cytology of parotid neoplasms based on the Milan system-Experience from a tertiary center in Asia. 61
31131938 2019
49
Surgical treatment strategy in Warthin tumor of the parotid gland. 61
29807810 2019
50
Mucoepidermoid Carcinoma in Warthin Tumor of the Parotis in Childhood: A Case Report and Review of the Literature. 61
30198962 2019

Variations for Warthin Tumor

Expression for Warthin Tumor

Search GEO for disease gene expression data for Warthin Tumor.

Pathways for Warthin Tumor

GO Terms for Warthin Tumor

Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.5 MAML2 CRTC3 CRTC1
2 viral process GO:0016032 9.43 KRT7 CRTC3 CRTC1
3 protein homotetramerization GO:0051289 9.16 CRTC3 CRTC1
4 energy homeostasis GO:0097009 8.96 CRTC3 CRTC1
5 positive regulation of CREB transcription factor activity GO:0032793 8.62 CRTC3 CRTC1

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cAMP response element binding protein binding GO:0008140 8.62 CRTC3 CRTC1

Sources for Warthin Tumor

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7 CNVD
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10 dbSNP
11 DGIdb
17 EFO
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31 HPO
32 ICD10
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45 MESH via Orphanet
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53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
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71 UMLS via Orphanet
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