Aliases & Classifications for Warthin Tumor

MalaCards integrated aliases for Warthin Tumor:

Name: Warthin Tumor 53
Adenolymphoma 73

Classifications:



External Ids:

UMLS 73 C0001429

Summaries for Warthin Tumor

NIH Rare Diseases : 53 Warthin tumor is a benign tumor of the salivary gland. The first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. Warthin tumors may increase in size over time, but few become cancerous. Though the cause is currently unknown, smoking is believed to increase the chance of developing Warthin tumor. Treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time.

MalaCards based summary : Warthin Tumor, also known as adenolymphoma, is related to necrotizing sialometaplasia and mucoepidermoid carcinoma. An important gene associated with Warthin Tumor is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are p70S6K Signaling and MAPK signaling pathway. Affiliated tissues include salivary gland, lymph node and thyroid, and related phenotypes are growth/size/body region and cardiovascular system

Wikipedia : 76 Warthin\'s tumor, also known as papillary cystadenoma lymphomatosum, is a benign cystic tumor of the... more...

Related Diseases for Warthin Tumor

Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 necrotizing sialometaplasia 30.2 CRTC1 KIT MAML2
2 mucoepidermoid carcinoma 28.9 CEACAM5 CRTC1 CRTC3 MAML2
3 lacrimal gland mucoepidermoid carcinoma 10.8 CRTC1 MAML2
4 clear cell hidradenoma 10.7 CRTC1 MAML2
5 cervical adenosquamous carcinoma 10.6 CRTC1 MAML2
6 prostate leiomyosarcoma 10.6 CD44 KIT
7 gallbladder sarcoma 10.6 KIT KRT18
8 pleomorphic carcinoma 10.4 KIT KRT18
9 lipoadenoma 10.4 CRTC1 MAML2
10 skin atrophy 10.4 CD44 HBEGF
11 schneiderian carcinoma 10.4 CRTC1 KRT18 MAML2
12 papillary hidradenoma 10.4 ERBB4 KIT
13 hypereosinophilic syndrome, idiopathic 10.3 KIT TGFA
14 rheumatoid vasculitis 10.2 CD44 VCAM1
15 lymphoma 10.1
16 thyroiditis 10.0
17 liver leiomyoma 10.0 CEACAM5 KIT
18 fox-fordyce disease 10.0 CEACAM5 KIT
19 cervicitis 10.0
20 cystadenoma 10.0
21 pleomorphic adenoma 10.0
22 adenoma 10.0
23 adenoid basal cell carcinoma 10.0 CEACAM5 KIT
24 aggressive digital papillary adenocarcinoma 9.9 CEACAM5 KIT
25 cutaneous adenocystic carcinoma 9.9 CEACAM5 KRT18
26 rete testis adenocarcinoma 9.9 CEACAM5 KIT
27 ovarian lymphoma 9.9 CEACAM5 KRT18
28 thyroid cancer, nonmedullary, 1 9.9
29 adenocarcinoma 9.9
30 cutaneous mucoepidermoid carcinoma 9.8 CEACAM5 CRTC1 MAML2
31 cervical clear cell adenocarcinoma 9.8 CEACAM5 KRT18
32 leukemia, chronic lymphocytic 2 9.7
33 leukemia, chronic lymphocytic 9.7
34 lymphoma, hodgkin, classic 9.7
35 histiocytosis 9.7
36 langerhans cell histiocytosis 9.7
37 b-cell lymphomas 9.7
38 diffuse large b-cell lymphoma 9.7
39 cll/sll 9.7
40 leukemia 9.7
41 mantle cell lymphoma 9.7
42 peripheral t-cell lymphoma 9.7
43 actinomycosis 9.7
44 tongue cancer 9.7
45 nasopharyngitis 9.7
46 leukemia, b-cell, chronic 9.7
47 nodular lymphocyte predominant hodgkin lymphoma 9.7
48 squamous cell carcinoma 9.7
49 thyroid cancer 9.7
50 mandibular cancer 9.7

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to Warthin Tumor

Symptoms & Phenotypes for Warthin Tumor

MGI Mouse Phenotypes related to Warthin Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 KIT KRT18 TGFA TGFB2 VCAM1 CD44
2 cardiovascular system MP:0005385 9.87 CD44 ERBB4 HBEGF KIT TGFA TGFB2
3 muscle MP:0005369 9.7 CD44 CRTC3 ERBB4 HBEGF KIT TGFA
4 reproductive system MP:0005389 9.5 CD44 CRTC1 ERBB4 KIT TGFA TGFB2
5 respiratory system MP:0005388 9.1 CD44 ERBB4 HBEGF KIT TGFB2 THY1

Drugs & Therapeutics for Warthin Tumor

Search Clinical Trials , NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

Anatomical Context for Warthin Tumor

MalaCards organs/tissues related to Warthin Tumor:

41
Salivary Gland, Lymph Node, Thyroid, Tongue, B Cells, T Cells, Lung

Publications for Warthin Tumor

Articles related to Warthin Tumor:

(show top 50) (show all 85)
# Title Authors Year
1
JOURNAL CLUB: The Warthin Tumor Score: A Simple and Reliable Method to Distinguish Warthin Tumors From Pleomorphic Adenomas and Carcinomas. ( 29667889 )
2018
2
Surgical treatment strategy in Warthin tumor of the parotid gland. ( 29807810 )
2018
3
Warthin Tumor-Like Mucoepidermoid Carcinoma. ( 28793830 )
2017
4
Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in a Warthin Tumor: Case Report and Literature Review. ( 28978260 )
2017
5
Extracapsular dissection for Warthin tumor in the tail of parotid gland. ( 28446044 )
2017
6
Incidental finding of upper lip Warthin tumor. ( 29134953 )
2017
7
If cytology of Warthin tumor is accurate, can management be conservative? ( 27140020 )
2016
8
Letter to the Editor: Multinucleated cells in parotid Warthin tumor: a potential diagnostic pitfall? ( 28174818 )
2016
9
Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Benign Warthin Tumor of the Thyroid. ( 27438374 )
2016
10
Diagnostic pitfalls of infarcted Warthin tumor in frozen section evaluation. ( 27806841 )
2016
11
Incidental Warthin Tumor on Pertechnetate Scintigraphy. ( 27405035 )
2016
12
Warthin tumor within the superficial lobe of the parotid gland: a suggested criterion for diagnosis. ( 28013343 )
2016
13
Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland: A Case Report and Literature Review. ( 26169920 )
2015
14
EBV-positive diffuse large B-cell lymphoma of the elderly involving Warthin tumor. ( 26119391 )
2015
15
Synchronous parotid and nasopharyngeal Warthin tumor. ( 26315140 )
2015
16
An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. ( 26634829 )
2015
17
Mucoepidermoid carcinoma in Warthin tumor of the parotid gland. ( 26170867 )
2015
18
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy. ( 25816418 )
2015
19
Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor. ( 25992164 )
2015
20
Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland. ( 25149652 )
2014
21
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. ( 24565204 )
2014
22
Misleading appearance in cervical lymph node US diagnosis - a report on sarcoidosis, Warthin tumor and squamous cell carcinoma metastases. ( 24791853 )
2014
23
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. ( 24880872 )
2014
24
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. ( 24350077 )
2013
25
The Association of Warthin Tumor with Salivary Ductal Inclusions in Intra and Periparotid Lymph Nodes. ( 23868565 )
2013
26
Letter to the editor. parotid Warthin tumor with mucous differentiation. ( 23529335 )
2013
27
Warthin tumor with signet-ring cell features as a pitfall in salivary gland cytopathology. ( 23635480 )
2013
28
Warthin tumor in an unusual site: a case report. ( 23715204 )
2013
29
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. ( 23579981 )
2013
30
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. ( 24121173 )
2013
31
Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation. ( 23863526 )
2013
32
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. ( 22990554 )
2012
33
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. ( 22991990 )
2012
34
Adenocarcinoma arising in warthin tumor of the parotid gland. ( 23011833 )
2012
35
Mycobacterial tuberculosis superimposed on a Warthin tumor. ( 22614566 )
2012
36
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. ( 22227551 )
2012
37
Warthin tumor arising from the minor salivary gland. ( 22976673 )
2012
38
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. ( 21591273 )
2012
39
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. ( 22976724 )
2012
40
Correct diagnosis of Warthin tumor in the parotid gland with dynamic MRI. ( 22576704 )
2012
41
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. ( 21934225 )
2011
42
Fluorodeoxyglucose-positive Warthin tumor in a neck node mimicking metastasis in primary intraosseous left posterior mandibular cancer staging with positron emission tomography/computed tomography. ( 21549478 )
2011
43
Warthin tumor--morphological study of the stromal compartment. ( 22203940 )
2011
44
Extraparotid Warthin tumor in upper cervical lymph node accompanied by primary cervical tuberculosis. ( 21493251 )
2011
45
Brucella melitensis infection within warthin tumor of the parotid gland. ( 21959459 )
2011
46
Warthin tumor of the upper lip: an unusual location of a benign salivary gland tumor. ( 19189998 )
2011
47
Genomic aberrations in salivary duct carcinoma arising in Warthin tumor of parotid gland: DNA microarray and HER2 fluorescence in situ hybridization. ( 21877991 )
2011
48
A case of coexisting Warthin tumor and langerhans cell histiocytosis associated with necrosis, eosinophilic abscesses and a granulomatous reaction in intraparotid lymph nodes. ( 21769315 )
2011
49
Warthin tumor: a potential source of diagnostic error. ( 21119475 )
2010
50
Warthin tumor presenting as a fungal abscess in an immunocompetent host: case report and review of the literature. ( 19340859 )
2010

Variations for Warthin Tumor

Expression for Warthin Tumor

Search GEO for disease gene expression data for Warthin Tumor.

Pathways for Warthin Tumor

GO Terms for Warthin Tumor

Cellular components related to Warthin Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.91 CD44 CEACAM5 CRTC1 ERBB4 HBEGF KIT
2 integral component of plasma membrane GO:0005887 9.5 CD44 CEACAM5 ERBB4 HBEGF KIT TGFA
3 basolateral plasma membrane GO:0016323 9.33 CEACAM5 ERBB4 TGFA
4 cell surface GO:0009986 9.1 CD44 HBEGF KIT TGFA THY1 VCAM1

Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.85 CRTC1 CRTC3 KRT18 VCAM1
2 protein autophosphorylation GO:0046777 9.76 ERBB4 KIT THY1
3 peptidyl-tyrosine phosphorylation GO:0018108 9.75 ERBB4 HBEGF KIT
4 positive regulation of protein kinase B signaling GO:0051897 9.73 ERBB4 HBEGF KIT
5 phosphatidylinositol phosphorylation GO:0046854 9.67 ERBB4 HBEGF KIT
6 positive regulation of cell proliferation GO:0008284 9.65 ERBB4 HBEGF KIT TGFA TGFB2
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.63 CD44 HBEGF TGFA
8 energy homeostasis GO:0097009 9.6 CRTC1 CRTC3
9 regulation of cell motility GO:2000145 9.59 ERBB4 HBEGF
10 cell chemotaxis GO:0060326 9.58 HBEGF KIT VCAM1
11 positive regulation of JAK-STAT cascade GO:0046427 9.57 ERBB4 KIT
12 mammary gland alveolus development GO:0060749 9.54 ERBB4 TGFA
13 positive regulation of kinase activity GO:0033674 9.54 CD44 ERBB4 KIT
14 positive regulation of CREB transcription factor activity GO:0032793 9.52 CRTC1 CRTC3
15 negative regulation of ERBB signaling pathway GO:1901185 9.51 ERBB4 HBEGF
16 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.5 ERBB4 KIT TGFB2
17 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 CD44 THY1
18 somatic stem cell division GO:0048103 9.43 KIT TGFB2
19 positive regulation of Notch signaling pathway GO:0045747 9.33 KIT MAML2 TGFB2
20 cell-cell adhesion GO:0098609 9.26 CD44 KRT18 THY1 VCAM1
21 negative regulation of apoptotic process GO:0043066 9.1 CD44 CEACAM5 ERBB4 KIT KRT18 TGFA

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein tyrosine kinase activity GO:0004713 9.61 ERBB4 HBEGF KIT
2 growth factor activity GO:0008083 9.58 HBEGF TGFA TGFB2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.54 ERBB4 HBEGF KIT
4 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.32 ERBB4 KIT
5 cAMP response element binding protein binding GO:0008140 9.26 CRTC1 CRTC3
6 GPI anchor binding GO:0034235 9.16 CEACAM5 THY1
7 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.13 ERBB4 HBEGF KIT
8 epidermal growth factor receptor binding GO:0005154 8.8 ERBB4 HBEGF TGFA

Sources for Warthin Tumor

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