MCID: WRT003
MIFTS: 40

Warthin Tumor

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Warthin Tumor

MalaCards integrated aliases for Warthin Tumor:

Name: Warthin Tumor 54 17
Adenolymphoma 74

Classifications:



External Ids:

UMLS 74 C0001429

Summaries for Warthin Tumor

NIH Rare Diseases : 54 Warthin tumor is a benign tumor of the salivary gland. The first symptom is usually a painless, slow-growing bump in front of the ear, on the bottom of the mouth, or under the chin. Warthin tumors may increase in size over time, but few become cancerous. Though the cause is currently unknown, smoking is believed to increase the chance of developing Warthin tumor. Treatment may consist of surgery to remove the tumor or careful observation to watch for changes in the tumor over time.

MalaCards based summary : Warthin Tumor, also known as adenolymphoma, is related to mucoepidermoid carcinoma and necrotizing sialometaplasia. An important gene associated with Warthin Tumor is MAML2 (Mastermind Like Transcriptional Coactivator 2), and among its related pathways/superpathways are p70S6K Signaling and MAPK signaling pathway. Affiliated tissues include salivary gland, lymph node and thyroid, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Warthin''s tumor, also known as papillary cystadenoma lymphomatosum, is a benign cystic tumor of the... more...

Related Diseases for Warthin Tumor

Diseases related to Warthin Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 mucoepidermoid carcinoma 29.9 CEACAM5 CRTC1 CRTC3 KRT7 MAML2
2 necrotizing sialometaplasia 29.8 CRTC1 KIT KRT7 MAML2
3 lacrimal gland mucoepidermoid carcinoma 10.4 CRTC1 MAML2
4 clear cell hidradenoma 10.4 CRTC1 MAML2
5 prostate leiomyosarcoma 10.4 CD44 KIT
6 gallbladder sarcoma 10.4 KIT KRT18
7 lymphoepithelioma-like thymic carcinoma 10.3 KIT KRT18
8 lymphoma 10.3
9 liver leiomyoma 10.3 CEACAM5 KIT
10 schneiderian carcinoma 10.3 CRTC1 KRT18 MAML2
11 fox-fordyce disease 10.3 CEACAM5 KIT
12 papillary hidradenoma 10.3 ERBB4 KIT
13 hidradenoma 10.3 KRT7 MAML2
14 aggressive digital papillary adenocarcinoma 10.2 CEACAM5 KIT
15 proliferating trichilemmal cyst 10.2 KRT18 KRT7
16 ovarian lymphoma 10.2 CEACAM5 KRT18
17 ceruminoma 10.2 KIT KRT7
18 jejunal cancer 10.2 KIT KRT7
19 epithelioid trophoblastic tumor 10.2 KRT18 KRT7
20 rete testis adenocarcinoma 10.2 CEACAM5 KIT
21 rheumatoid vasculitis 10.2 CD44 VCAM1
22 intratubular embryonal carcinoma 10.2 KIT KRT7
23 thyroid cancer 10.2
24 cribriform carcinoma 10.2 KIT KRT7
25 skin atrophy 10.2 CD44 HBEGF
26 malignant leydig cell tumor 10.2 KIT KRT7
27 seminal vesicle tumor 10.2 KRT18 KRT7
28 metanephric adenoma 10.2 KRT18 KRT7
29 breast mucoepidermoid carcinoma 10.2 CEACAM5 CRTC1 MAML2
30 thyroid cancer, nonmedullary, 1 10.2
31 cystadenoma 10.2
32 rete testis neoplasm 10.1 CEACAM5 KIT
33 anal gland adenocarcinoma 10.1 CEACAM5 KRT7
34 mucinous tubular and spindle renal cell carcinoma 10.1 KRT18 KRT7
35 mucinous adenofibroma 10.1 CEACAM5 KRT7
36 anus adenocarcinoma 10.1 CEACAM5 KRT7
37 malignant spiradenoma 10.1 CEACAM5 KRT7
38 hypereosinophilic syndrome, idiopathic 10.1 KIT TGFA
39 lipoadenoma 10.1 CRTC1 KRT7 MAML2
40 cervical adenosquamous carcinoma 10.1 CRTC1 KRT7 MAML2
41 salivary gland disease 10.1 CRTC1 CRTC3 MAML2
42 bile duct mucoepidermoid carcinoma 10.1 CEACAM5 KRT7
43 paget disease, extramammary 10.1 ERBB4 KRT7
44 nodular hidradenoma 10.1 CEACAM5 KRT7
45 vulval paget's disease 10.1 CEACAM5 KRT7
46 bile duct cystadenocarcinoma 10.1 CEACAM5 KRT7
47 pancreatic serous cystadenoma 10.1 CEACAM5 KRT7
48 thymus adenocarcinoma 10.1 CEACAM5 KRT7
49 lymphoepithelioma-like carcinoma 10.1 KRT18 KRT7
50 meibomian cyst 10.1 CEACAM5 KRT7

Graphical network of the top 20 diseases related to Warthin Tumor:



Diseases related to Warthin Tumor

Symptoms & Phenotypes for Warthin Tumor

GenomeRNAi Phenotypes related to Warthin Tumor according to GeneCards Suite gene sharing:

27 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.53 TGFB2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.53 TGFB2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.53 KRT18
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.53 KRT18
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.53 TGFB2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.53 KRT18
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.53 TGFB2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.53 TGFB2
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.53 KRT7
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.53 KRT18 KRT7 TGFB2
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.53 KRT7 TGFB2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.53 KRT18
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.53 KRT7

MGI Mouse Phenotypes related to Warthin Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 CD44 CRTC1 CRTC3 HBEGF KIT KRT18
2 muscle MP:0005369 9.7 CD44 CRTC3 ERBB4 HBEGF KIT TGFA
3 reproductive system MP:0005389 9.5 CD44 CRTC1 ERBB4 KIT TGFA TGFB2
4 respiratory system MP:0005388 9.1 CD44 ERBB4 HBEGF KIT TGFB2 THY1

Drugs & Therapeutics for Warthin Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multiparametric Magnetic Resonance Imaging Versus Fine Needle Aspiration Cytology for Parotid Gland Neoplasms Recruiting NCT03849482

Search NIH Clinical Center for Warthin Tumor

Genetic Tests for Warthin Tumor

Anatomical Context for Warthin Tumor

MalaCards organs/tissues related to Warthin Tumor:

42
Salivary Gland, Lymph Node, Thyroid, Tongue, T Cells, B Cells

Publications for Warthin Tumor

Articles related to Warthin Tumor:

(show top 50) (show all 164)
# Title Authors Year
1
Infarcted Warthin tumor with mucoepidermoid carcinoma-like metaplasia: a case report and review of the literature. ( 30636634 )
2019
2
JOURNAL CLUB: The Warthin Tumor Score: A Simple and Reliable Method to Distinguish Warthin Tumors From Pleomorphic Adenomas and Carcinomas. ( 29667889 )
2018
3
Surgical treatment strategy in Warthin tumor of the parotid gland. ( 29807810 )
2018
4
Mucoepidermoid Carcinoma in Warthin Tumor of the Parotis in Childhood: A Case Report and Review of the Literature. ( 30198962 )
2018
5
Warthin tumor of the larynx: A case report and review of the literature. ( 30036439 )
2018
6
Warthin tumor of the oropharyngeal minor salivary gland. ( 30574313 )
2018
7
Clinical Application of Real-Time Shear Wave Elastography in Identifying the Histological Components of Parotid Adenolymphoma. ( 29346263 )
2018
8
Diffusion kurtosis imaging in the differential diagnosis of parotid gland disease and parotid adenolymphoma: preliminary results. ( 29676939 )
2018
9
Warthin Tumor-Like Mucoepidermoid Carcinoma. ( 28793830 )
2017
10
Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in a Warthin Tumor: Case Report and Literature Review. ( 28978260 )
2017
11
Extracapsular dissection for Warthin tumor in the tail of parotid gland. ( 28446044 )
2017
12
Incidental finding of upper lip Warthin tumor. ( 29134953 )
2017
13
If cytology of Warthin tumor is accurate, can management be conservative? ( 27140020 )
2016
14
Letter to the Editor: Multinucleated cells in parotid Warthin tumor: a potential diagnostic pitfall? ( 28174818 )
2016
15
Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Benign Warthin Tumor of the Thyroid. ( 27438374 )
2016
16
Diagnostic pitfalls of infarcted Warthin tumor in frozen section evaluation. ( 27806841 )
2016
17
Incidental Warthin Tumor on Pertechnetate Scintigraphy. ( 27405035 )
2016
18
Warthin tumor within the superficial lobe of the parotid gland: a suggested criterion for diagnosis. ( 28013343 )
2016
19
Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland: A Case Report and Literature Review. ( 26169920 )
2015
20
EBV-positive diffuse large B-cell lymphoma of the elderly involving Warthin tumor. ( 26119391 )
2015
21
Synchronous parotid and nasopharyngeal Warthin tumor. ( 26315140 )
2015
22
An unusual initial presentation of mantle cell lymphoma arising from the lymphoid stroma of warthin tumor. ( 26634829 )
2015
23
Mucoepidermoid carcinoma in Warthin tumor of the parotid gland. ( 26170867 )
2015
24
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy. ( 25816418 )
2015
25
Parotid incidentaloma identified by positron emission/computed tomography: when to consider diagnoses other than warthin tumor. ( 25992164 )
2015
26
Recoverin-associated retinopathy secondary to Warthin tumor of parotid gland. ( 25149652 )
2014
27
Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor. ( 24565204 )
2014
28
Misleading appearance in cervical lymph node US diagnosis - a report on sarcoidosis, Warthin tumor and squamous cell carcinoma metastases. ( 24791853 )
2014
29
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor. ( 24880872 )
2014
30
Imaging, clinical and pathological features of salivary gland adenolymphoma. ( 25535134 )
2014
31
Mycobacterium Tuberculosis Infection within a Warthin Tumor: A Case Report and Literature Review. ( 24350077 )
2013
32
The Association of Warthin Tumor with Salivary Ductal Inclusions in Intra and Periparotid Lymph Nodes. ( 23868565 )
2013
33
Letter to the editor. parotid Warthin tumor with mucous differentiation. ( 23529335 )
2013
34
Warthin tumor with signet-ring cell features as a pitfall in salivary gland cytopathology. ( 23635480 )
2013
35
Warthin tumor in an unusual site: a case report. ( 23715204 )
2013
36
SPECT/CT demonstrating 131I retention in warthin tumor on thyroid cancer survey scan. ( 23579981 )
2013
37
CRTC1-MAML2 and CRTC3-MAML2 fusions were not detected in metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands. ( 24121173 )
2013
38
Two-phase computed tomography study of warthin tumor of parotid gland: differentiation from other parotid gland tumors and its pathologic explanation. ( 23863526 )
2013
39
Adenolymphoma: A probing entity: Case report and review. ( 24082763 )
2013
40
Immunohistochemical expression of CK7, CK5/6, CK19, and p63 in Warthin tumor. ( 22990554 )
2012
41
Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. ( 22991990 )
2012
42
Adenocarcinoma arising in warthin tumor of the parotid gland. ( 23011833 )
2012
43
Mycobacterial tuberculosis superimposed on a Warthin tumor. ( 22614566 )
2012
44
Fine needle aspiration diagnosis of ipsilateral synchronous neoplasm - mucoepidermoid carcinoma with warthin tumor in parotid gland. ( 22227551 )
2012
45
Warthin tumor arising from the minor salivary gland. ( 22976673 )
2012
46
False-positive FDG PET/CT uptake in Warthin tumor in head and neck oncological patients confirmed by a fine needle aspiration. ( 21591273 )
2012
47
18F-fluorodeoxyglucose-positive Warthin tumor in a contralateral cervical lymph node mimicking metastasis in tongue cancer staging with PET/CT. ( 22976724 )
2012
48
Correct diagnosis of Warthin tumor in the parotid gland with dynamic MRI. ( 22576704 )
2012
49
Atypical adenolymphoma and glomus caroticum tumour: a rare coincidence. ( 22545390 )
2012
50
High-grade adenocarcinoma, (ductal type) arising in unilateral Warthin tumor of the parotid gland. ( 21934225 )
2011

Variations for Warthin Tumor

Expression for Warthin Tumor

Search GEO for disease gene expression data for Warthin Tumor.

Pathways for Warthin Tumor

Pathways related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 HBEGF KIT TGFA TGFB2 VCAM1
2 12.5 ERBB4 KIT TGFA TGFB2
3 12.22 CD44 CEACAM5 KIT VCAM1
4
Show member pathways
12.22 ERBB4 HBEGF TGFA TGFB2
5
Show member pathways
12.15 ERBB4 KIT TGFA TGFB2
6
Show member pathways
11.94 HBEGF KIT TGFA TGFB2
7 11.9 CRTC1 CRTC3 TGFB2 VCAM1
8 11.87 ERBB4 KIT TGFA
9 11.85 HBEGF TGFA TGFB2
10 11.76 CD44 CEACAM5 VCAM1
11 11.56 CD44 ERBB4 HBEGF TGFB2
12 11.4 CD44 KIT THY1
13
Show member pathways
11.32 HBEGF TGFA TGFB2
14 11.12 CD44 ERBB4 HBEGF
15 11.03 TGFA TGFB2
16 10.99 CD44 CEACAM5 KIT THY1

GO Terms for Warthin Tumor

Cellular components related to Warthin Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.5 CD44 CEACAM5 ERBB4 HBEGF KIT THY1
2 basolateral plasma membrane GO:0016323 9.46 CD44 CEACAM5 ERBB4 TGFA
3 cell surface GO:0009986 9.17 CD44 CEACAM5 HBEGF KIT TGFA THY1

Biological processes related to Warthin Tumor according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.83 CRTC1 CRTC3 KRT18 KRT7
2 peptidyl-tyrosine phosphorylation GO:0018108 9.74 ERBB4 HBEGF KIT
3 protein autophosphorylation GO:0046777 9.73 ERBB4 KIT THY1
4 positive regulation of protein kinase B signaling GO:0051897 9.72 ERBB4 HBEGF KIT
5 positive regulation of cell proliferation GO:0008284 9.72 ERBB4 HBEGF KIT TGFA TGFB2
6 phosphatidylinositol phosphorylation GO:0046854 9.63 ERBB4 HBEGF KIT
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.61 CD44 HBEGF TGFA
8 ERBB2 signaling pathway GO:0038128 9.58 ERBB4 HBEGF
9 regulation of cell motility GO:2000145 9.58 ERBB4 HBEGF
10 cell chemotaxis GO:0060326 9.58 HBEGF KIT VCAM1
11 positive regulation of JAK-STAT cascade GO:0046427 9.54 ERBB4 KIT
12 mammary gland alveolus development GO:0060749 9.51 ERBB4 TGFA
13 positive regulation of CREB transcription factor activity GO:0032793 9.49 CRTC1 CRTC3
14 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.48 CD44 THY1
15 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.43 ERBB4 KIT TGFB2
16 somatic stem cell division GO:0048103 9.37 KIT TGFB2
17 positive regulation of Notch signaling pathway GO:0045747 9.33 KIT MAML2 TGFB2
18 cell-cell adhesion GO:0098609 9.26 CD44 KRT18 THY1 VCAM1
19 negative regulation of apoptotic process GO:0043066 8.92 CD44 CEACAM5 KRT18 TGFA

Molecular functions related to Warthin Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.58 HBEGF TGFA TGFB2
2 protein tyrosine kinase activity GO:0004713 9.54 ERBB4 HBEGF KIT
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.5 ERBB4 HBEGF KIT
4 cAMP response element binding protein binding GO:0008140 9.26 CRTC1 CRTC3
5 GPI anchor binding GO:0034235 9.16 CEACAM5 THY1
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.13 ERBB4 HBEGF KIT
7 epidermal growth factor receptor binding GO:0005154 8.8 ERBB4 HBEGF TGFA

Sources for Warthin Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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