MCID: WTR002
MIFTS: 24

Water-Clear Cell Adenoma

Categories: Cancer diseases

Aliases & Classifications for Water-Clear Cell Adenoma

MalaCards integrated aliases for Water-Clear Cell Adenoma:

Name: Water-Clear Cell Adenoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5401
NCIt 50 C4155
SNOMED-CT 68 26638004
UMLS 73 C0334321

Summaries for Water-Clear Cell Adenoma

Disease Ontology : 12 An adenoma that derives from epithelial cells which have clear cytoplasm.

MalaCards based summary : Water-Clear Cell Adenoma is related to clear cell adenoma and adenoma. An important gene associated with Water-Clear Cell Adenoma is PPP1R3C (Protein Phosphatase 1 Regulatory Subunit 3C), and among its related pathways/superpathways are Insulin resistance and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include thyroid and thymus, and related phenotype is homeostasis/metabolism.

Related Diseases for Water-Clear Cell Adenoma

Diseases related to Water-Clear Cell Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 clear cell adenoma 30.7 PTH TG
2 adenoma 10.5
3 hyperparathyroidism 10.3
4 parathyroid transitional clear cell adenoma 10.3
5 primary hyperparathyroidism 10.2
6 parathyroid gland disease 10.1 PPP1R3C PTH
7 barre-lieou syndrome 10.1 PPP1R3B PPP1R3C
8 sarcomatoid renal cell carcinoma 10.1 GATA3 PAX8
9 ovarian brenner tumor 10.0 GATA3 PAX8
10 sensory organ benign neoplasm 10.0 PAX8 SYP
11 mixed type thymoma 10.0 PAX8 SYP
12 connective tissue benign neoplasm 10.0 PTH SYP
13 thymus lipoma 10.0 PTH SYP
14 endocrine organ benign neoplasm 10.0 PTH SYP
15 hypoparathyroidism 10.0 GATA3 PTH
16 substernal goiter 10.0 PTH TG
17 endemic goiter 10.0 PTH TG
18 goiter 10.0 PAX8 TG
19 neonatal hypothyroidism 10.0 PAX8 TG
20 thymus cancer 10.0 PAX8 SYP
21 thyroid crisis 10.0 PTH TG
22 sweat gland cancer 10.0 GATA3 SYP
23 athyreosis 10.0 PAX8 TG
24 follicular adenoma 9.9 PAX8 TG
25 hypothyroidism, congenital, nongoitrous, 2 9.9 PAX8 TG
26 multinodular goiter 9.9 PAX8 TG
27 multiple endocrine neoplasia, type i 9.9 PTH SYP
28 anaplastic thyroid cancer 9.9 PAX8 TG
29 pendred syndrome 9.9 PAX8 TG
30 atypical follicular adenoma 9.9 SYP TG
31 spermatocele 9.9 SYP TG
32 papillary carcinoma 9.9 PAX8 TG
33 differentiated thyroid carcinoma 9.8 PAX8 TG
34 thyroid gland disease 9.8 PAX8 PTH TG
35 congenital hypothyroidism 9.8 PAX8 TG
36 cell type benign neoplasm 9.7 PTH SYP TG
37 endocrine gland cancer 9.7 PAX8 SYP TG
38 thyroid cancer, nonmedullary, 2 9.7 PAX8 TG

Graphical network of the top 20 diseases related to Water-Clear Cell Adenoma:



Diseases related to Water-Clear Cell Adenoma

Symptoms & Phenotypes for Water-Clear Cell Adenoma

MGI Mouse Phenotypes related to Water-Clear Cell Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 GATA3 PAX8 PPP1R3B PPP1R3C PTH TG

Drugs & Therapeutics for Water-Clear Cell Adenoma

Search Clinical Trials , NIH Clinical Center for Water-Clear Cell Adenoma

Genetic Tests for Water-Clear Cell Adenoma

Anatomical Context for Water-Clear Cell Adenoma

MalaCards organs/tissues related to Water-Clear Cell Adenoma:

41
Thyroid, Thymus

Publications for Water-Clear Cell Adenoma

Articles related to Water-Clear Cell Adenoma:

# Title Authors Year
1
Water Clear Cell Adenoma of the Parathyroid Gland: A Forgotten Cause of Primary Hyperparathyroidism. ( 28382826 )
2017
2
Water-Clear Cell Adenoma of the Mediastinal Parathyroid Gland. ( 28832084 )
2017
3
Water-clear cell adenoma of parathyroid gland - A case report. ( 27772915 )
2016
4
Water-clear cell adenoma associated with primary hyperparathyroidism: report of a case. ( 23539328 )
2013
5
Water-clear cell adenoma: A rare form of hyperparathyroidism. ( 23995477 )
2013
6
Water-clear cell adenoma of the parathyroid gland: a rare entity. ( 15471124 )
2004
7
Water-clear cell adenoma of the parathyroid. A case report with immunohistochemistry and electron microscopy. ( 7487410 )
1995

Variations for Water-Clear Cell Adenoma

Expression for Water-Clear Cell Adenoma

Search GEO for disease gene expression data for Water-Clear Cell Adenoma.

Pathways for Water-Clear Cell Adenoma

Pathways related to Water-Clear Cell Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.99 PPP1R3B PPP1R3C
2 10.65 GATA3 PTH

GO Terms for Water-Clear Cell Adenoma

Biological processes related to Water-Clear Cell Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.48 GATA3 PAX8
2 inner ear morphogenesis GO:0042472 9.46 GATA3 PAX8
3 positive regulation of signal transduction GO:0009967 9.43 GATA3 PTH
4 regulation of phosphoprotein phosphatase activity GO:0043666 9.4 PPP1R3B PPP1R3C
5 glycogen metabolic process GO:0005977 9.37 PPP1R3B PPP1R3C
6 ventricular septum development GO:0003281 9.32 GATA3 PAX8
7 thyroid gland development GO:0030878 9.26 PAX8 TG
8 mesonephros development GO:0001823 9.16 GATA3 PAX8
9 otic vesicle development GO:0071599 8.96 GATA3 PAX8
10 positive regulation of thyroid hormone generation GO:2000611 8.62 GATA3 PAX8

Molecular functions related to Water-Clear Cell Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 PTH TG
2 protein phosphatase regulator activity GO:0019888 8.62 PPP1R3B PPP1R3C

Sources for Water-Clear Cell Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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