MCID: WTR001
MIFTS: 37

Waterhouse-Friderichsen Syndrome

Categories: Endocrine diseases, Infectious diseases, Rare diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Waterhouse-Friderichsen Syndrome

MalaCards integrated aliases for Waterhouse-Friderichsen Syndrome:

Name: Waterhouse-Friderichsen Syndrome 11 19 58 75 43 14 16 71 31 33
Fatal Pneumococcal Waterhouse-Friderichsen Syndrome 19 71
Acute Adrenal Insufficiency with Meningococcal Septicaemia 33
Waterhouse-Friderichsen Syndrome, Meningococcal 71
Meningococcal Waterhouse-Friderichsen Syndrome 33
Meningococcal Haemorrhagic Adrenalitis 33
Meningococcal Hemorrhagic Adrenalitis 11
Haemorrhagic Meningococcal Adrenitis 33
Waterhouse-Friderichsen Disease 33
Meningococcal Adrenal Syndrome 33
Adrenal Haemorrhage Syndrome 33

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

Disease Ontology 11 DOID:9931
MeSH 43 D014884
NCIt 49 C85225
SNOMED-CT 68 267484005
ICD10 31 A39.1
MESH via Orphanet 44 D014884
ICD10 via Orphanet 32 A39.1+ E35.1*
UMLS via Orphanet 72 C0043068 C1403891
Orphanet 58 ORPHA100067
ICD11 33 2072098125
UMLS 71 C0043068 C1403891 C2931288

Summaries for Waterhouse-Friderichsen Syndrome

GARD: 19 Waterhouse–Friderichsen syndrome is adrenal gland failure due to bleeding into the adrenal gland. It is usually caused by severe meningococcal infection or other severe, bacterial infection. Symptoms include acute adrenal gland insufficiency, and profound shock. Waterhouse–Friderichsen syndrome mainly occurs in children, but can occur in adults.

MalaCards based summary: Waterhouse-Friderichsen Syndrome, also known as fatal pneumococcal waterhouse-friderichsen syndrome, is related to premature ovarian failure 7 and kidney cortex necrosis. An important gene associated with Waterhouse-Friderichsen Syndrome is POMC (Proopiomelanocortin), and among its related pathways/superpathways are G alpha (s) signalling events and "Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction". Affiliated tissues include adrenal gland, spleen and bone marrow, and related phenotypes are homeostasis/metabolism and cellular

Disease Ontology: 11 An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland.

Wikipedia: 75 Waterhouse-Friderichsen syndrome (WFS) is defined as adrenal gland failure due to bleeding into the... more...

Related Diseases for Waterhouse-Friderichsen Syndrome

Diseases related to Waterhouse-Friderichsen Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 371)
# Related Disease Score Top Affiliating Genes
1 premature ovarian failure 7 31.4 POMC CRH
2 kidney cortex necrosis 30.8 F3 F2
3 purpura fulminans 30.7 SERPINC1 F3 F2
4 exanthem 30.6 F3 F2 CRP
5 chickenpox 30.5 F2 CRP
6 toxic shock syndrome 30.5 SERPINC1 F3 CRP
7 purpura 30.5 SERPINC1 F3 F2 CRP
8 disseminated intravascular coagulation 30.4 SERPINC1 F3 F2 CRP
9 pleural empyema 30.3 F2 CRP
10 lipoid congenital adrenal hyperplasia 30.2 POMC MC2R CRH
11 epidural abscess 30.2 F3 F2 CRP
12 necrotizing fasciitis 30.2 F3 F2 CRP
13 cholangitis 30.1 F3 F2 CRP
14 vitamin k deficiency bleeding 30.0 SERPINC1 F3 F2
15 thrombophilia due to thrombin defect 30.0 SERPINC1 F3 F2
16 sickle cell anemia 29.8 SERPINC1 F3 F2 CRP
17 hemorrhagic disease 29.6 SERPINC1 F3 F2 CRP
18 respiratory failure 29.5 SERPINC1 F3 F2 CRP
19 liver cirrhosis 29.4 SERPINC1 F3 F2
20 acute adrenal insufficiency 11.4
21 meningitis 10.8
22 meningococcal infection 10.8
23 meningococcemia 10.8
24 haemophilus influenzae 10.7
25 bilateral massive adrenal hemorrhage 10.6
26 bacteremia 2 10.5
27 meningococcal meningitis 10.5
28 right atrial isomerism 10.4
29 shwartzman phenomenon 10.3
30 klebsiella infection 10.3
31 medulloadrenal hyperfunction 10.3 POMC F3
32 factitious disorder 10.3 POMC F2
33 qualitative platelet defect 10.2 F3 F2
34 leech infestation 10.2 F3 F2
35 ureteric orifice cancer 10.2 F3 F2
36 schizophrenia 14 10.2 POMC ACR
37 acquired von willebrand syndrome 10.2 F3 F2
38 heparin-induced thrombocytopenia 10.2 F3 F2
39 gastric hemangioma 10.2 F3 F2
40 ectopic cushing syndrome 10.2 POMC CRH
41 splenic sequestration 10.2 F3 F2
42 pituitary infarct 10.2 POMC CRH
43 somatization disorder 10.2 POMC CRH
44 sheehan syndrome 10.2 POMC CRH
45 gangliocytoma 10.2 POMC CRH
46 hypothalamic disease 10.2 POMC CRH
47 angiodysplasia 10.2 F3 F2
48 acute stress disorder 10.2 POMC CRH
49 melancholia 10.2 POMC CRH
50 nelson syndrome 10.2 POMC CRH

Graphical network of the top 20 diseases related to Waterhouse-Friderichsen Syndrome:



Diseases related to Waterhouse-Friderichsen Syndrome

Symptoms & Phenotypes for Waterhouse-Friderichsen Syndrome

MGI Mouse Phenotypes related to Waterhouse-Friderichsen Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 CRH CRP F2 F3 MARCO MC2R
2 cellular MP:0005384 9.76 ACR CRH F2 F3 MARCO POMC
3 immune system MP:0005387 9.61 CRH CRP F2 F3 MARCO MC2R
4 hematopoietic system MP:0005397 9.23 CRH F2 F3 MARCO MC2R POMC

Drugs & Therapeutics for Waterhouse-Friderichsen Syndrome

Search Clinical Trials, NIH Clinical Center for Waterhouse-Friderichsen Syndrome

Cochrane evidence based reviews: waterhouse-friderichsen syndrome

Genetic Tests for Waterhouse-Friderichsen Syndrome

Anatomical Context for Waterhouse-Friderichsen Syndrome

Organs/tissues related to Waterhouse-Friderichsen Syndrome:

MalaCards : Adrenal Gland, Spleen, Bone Marrow, Skin, Lung, Endothelial, Bone

Publications for Waterhouse-Friderichsen Syndrome

Articles related to Waterhouse-Friderichsen Syndrome:

(show top 50) (show all 311)
# Title Authors PMID Year
1
Three Autopsy Cases of Non-Meningococcal Waterhouse-Friderichsen Syndrome with Hypoplastic Spleen or Post-Splenectomy Status. 62
36261354 2022
2
Lethal Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus in an asplenic patient. 62
35978295 2022
3
Waterhouse-Friderichsen Syndrome with Bilateral Adrenal Hemorrhage Associated with Methicillin-Resistant Staphylococcus aureus (MRSA) Bacteremia in an Adult Patient with History of Intravenous Drug Use. 62
35418553 2022
4
Waterhouse-Friderichsen syndrome in a cat with Klebsiella spp. infection. 62
33949088 2021
5
Fatal Waterhouse-Friderichsen syndrome in an adult due to serogroup Y Neisseria meningitidis. 62
33541984 2021
6
Fast Clinical, but Long-Term, Biochemical Remission after Waterhouse-Friderichsen Syndrome. 62
33542844 2021
7
Illustrated Forensic Pathology: Fatal Waterhouse-Friderichsen Syndrome. 62
32796209 2020
8
A Rare Case of Waterhouse-Friderichsen Syndrome Without Purpura Secondary to Haemophilus Influenzae. 62
32923222 2020
9
Neisseria meningitidis Induced Fatal Waterhouse-Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure. 62
32192003 2020
10
Waterhouse-Friderichsen Syndrome in an Infant. 62
32234194 2020
11
A unique fatal case of Waterhouse-Friderichsen syndrome caused by Proteus mirabilis in an immunocompetent subject: Case report and literature analysis. 62
31441842 2019
12
The importance of the postmortem interval for the diagnosis of Waterhouse-Friderichsen syndrome by Neisseria meningitidis in a series of forensic cases. 62
31372361 2019
13
Rare case of meningococcal sepsis-induced testicular failure, primary hypothyroidism and hypoadrenalism: Is there a link? 62
30219775 2018
14
[The Waterhouse-Friderichsen syndrome]. 62
30040272 2018
15
A case report of spontaneous staphylococcal meningitis in a cynomolgus monkey. 62
29399828 2018
16
[Management of severe sepsis using a Cytokin-adsorber]. 62
29247319 2018
17
Why Asplenic Patients Should Not Take Care of the Neighbour's Dog? A Fatal Course of Capnocytophaga canimorsus Sepsis. 62
30174969 2018
18
A rare case of Waterhouse- Friderichsen syndrome during primary Varicella zoster infection. 62
29219830 2017
19
Atriobronchial Fistula Complicated by Septic Cerebral Air Emboli After Pulmonary Vein Ablation. 62
28441232 2017
20
Waterhouse-Friderichsen syndrome due to Neisseria meningitidis infection in a young adult with thrombotic microangiopathy and eculizumab treatment: case report and review of management. 62
28213751 2017
21
Streptococcus Pneumoniae Detection Long Time After Death in a Fatal Case of Waterhouse-Friderichsen Syndrome. 62
28009598 2017
22
[Dyspnea and skin rash in a 49-year-old male patient]. 62
27900398 2017
23
A Case of Waterhouse-Friderichsen Syndrome Resulting from an Invasive Pneumococcal Infection in a Patient with a Hypoplastic Spleen. 62
26942021 2016
24
Fatal purpura fulminans and Waterhouse-Friderichsen syndrome from fulminant Streptococcus pneumoniae sepsis in an asplenic young adult. 62
27583208 2016
25
A rare case of Waterhouse-Friderichsen syndrome caused by Capnocytophaga canimorsus in an immunocompetent patient. 62
25676131 2015
26
An autopsy case of pneumococcal Waterhouse-Friderichsen syndrome with possible functional asplenia/hyposplenia. 62
26261663 2015
27
Fatal Waterhouse-Friderichsen syndrome due to serotype C Neisseria meningitidis in a young HIV negative MSM (men who have sex with men). 62
25267809 2014
28
Waterhouse Friderichsen syndrome complicating fulminant Enterobacter cloacae sepsis in a preterm infant: the unresolved issue of corticosteroids. 62
24328998 2014
29
[Acute adrenal insufficiency. Easy to miss Waterhouse-Friderichsen syndrome, as shown in two cases]. 62
24187895 2013
30
A fatal case of streptococcal and meningococcal meningitis in a 2-years-old child occurring as Waterhouse-Friderichsen Syndrome. 62
23910860 2013
31
Adrenomegaly and septic adrenal hemorrhage (Waterhouse-Friderichsen syndrome) in the setting of congenital adrenal hyperplasia. 62
23814386 2013
32
The significance of adrenal hemorrhage: undiagnosed Waterhouse-Friderichsen syndrome, a case series. 62
23458363 2013
33
Waterhouse-friderichsen syndrome in an adult patient with meningococcal meningitis. 62
23716842 2013
34
[Case report: A case of invasive pneumococcal disease with purpura fulminans and Waterhouse-Friderichsen syndrome]. 62
22693858 2012
35
Neisseria meningitidis induces platelet inhibition and increases vascular endothelial permeability via nitric oxide regulated pathways. 62
22072136 2011
36
A case of functional asplenia and pneumococcal sepsis. 62
21730800 2011
37
Waterhouse-friderichsen syndrome in an adult patient with meningococcal meningitis. 62
21772601 2011
38
Fatal dog bite in the absence of significant trauma: Capnocytophaga canimorsus infection and unexpected death. 62
20407357 2010
39
Waterhouse-friderichsen syndrome caused by invasive haemophilus influenzae type B infection in a previously healthy young man. 62
20191807 2010
40
Systemic inflammatory response syndrome in nonhuman primates culminating in multiple organ failure, acute lung injury, and disseminated intravascular coagulation. 62
19773593 2009
41
Fatal pneumococcal Waterhouse-Friderichsen syndrome in a vaccinated adult with congenital asplenia. 62
19751638 2009
42
[Puerperal septic shock due to beta-hemolytic Streptococcus and Waterhouse-Friderichsen syndrome]. 62
19287940 2009
43
[Foudroyant meningococcal sepsis in emergency medicine. Medical treatment and post-exposure prophylaxis]. 62
18270671 2008
44
Overwhelming postsplenectomy infection syndrome in adults - a clinically preventable disease. 62
18186551 2008
45
[Waterhouse-Friderichsen syndrome associated to a Morganella morganii and Enterococcus faecium peritonitis]. 62
17766079 2007
46
Medical image. Meningococcal septic shock with adrenal apoplexy--Waterhouse-Friderichsen syndrome. 62
16868589 2006
47
Invasive meningococcal disease associated with a very high case fatality rate in the North-West of Poland. 62
16487304 2006
48
Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children. 62
16177250 2005
49
Case of Waterhouse Friderichsen Syndrome during outbreak of meningococcal disease in Delhi in May 2005. 62
16749283 2005
50
OPSI (overwhelming postsplenectomy infection) syndrome: a case report. 62
15639588 2004

Variations for Waterhouse-Friderichsen Syndrome

Expression for Waterhouse-Friderichsen Syndrome

Search GEO for disease gene expression data for Waterhouse-Friderichsen Syndrome.

Pathways for Waterhouse-Friderichsen Syndrome

Pathways related to Waterhouse-Friderichsen Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.33 POMC MC2R CRH
2 10.89 F3 F2
3
Show member pathways
10.73 POMC CRP
4
Show member pathways
10.62 POMC CRH
5 9.47 POMC CRH

GO Terms for Waterhouse-Friderichsen Syndrome

Biological processes related to Waterhouse-Friderichsen Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.43 SERPINC1 F3 F2
2 regulation of blood coagulation GO:0030193 9.33 SERPINC1 F2
3 hemostasis GO:0007599 8.8 SERPINC1 F3 F2

Molecular functions related to Waterhouse-Friderichsen Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.1 SERPINC1 F3 ACR

Sources for Waterhouse-Friderichsen Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....