ALT
MCID: WLL039
MIFTS: 39

Well-Differentiated Liposarcoma (ALT)

Categories: Rare diseases

Aliases & Classifications for Well-Differentiated Liposarcoma

MalaCards integrated aliases for Well-Differentiated Liposarcoma:

Name: Well-Differentiated Liposarcoma 60 17
Atypical Lipoma 60 74
Liposarcoma, Well Differentiated 74
Atypical Lipomatous Tumor 60
Pleomorphic Lipoma 74
Wdls 60
Alt 60

Characteristics:

Orphanet epidemiological data:

60
well-differentiated liposarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

ICD10 via Orphanet 35 C49.9
UMLS via Orphanet 75 C1370889
Orphanet 60 ORPHA99971
SNOMED-CT via HPO 70 39539005 95325000

Summaries for Well-Differentiated Liposarcoma

MalaCards based summary : Well-Differentiated Liposarcoma, also known as atypical lipoma, is related to pleomorphic lipoma and liposarcoma. An important gene associated with Well-Differentiated Liposarcoma is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are Viral carcinogenesis and Cellular senescence (KEGG). Affiliated tissues include testes, tongue and skin, and related phenotypes are subcutaneous nodule and abnormal renal physiology

Related Diseases for Well-Differentiated Liposarcoma

Diseases related to Well-Differentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 31.5 HMGA2 MDM2
2 liposarcoma 31.2 CDK4 CDKN2A HMGA2 MDM2 TSPAN31
3 lipomatosis, multiple 31.2 CDK4 HMGA2 MDM2
4 dedifferentiated liposarcoma 30.7 CDK4 CDKN2A HMGA2 MDM2
5 atypical lipomatous tumor 30.7 CDK4 CDKN2A HMGA2 MDM2 TSPAN31
6 lipoblastoma 30.7 CDK4 MDM2
7 infiltrating lipoma 30.6 CDK4 HMGA2 MDM2
8 myxoid liposarcoma 30.6 CDK4 HMGA2 MDM2
9 spindle cell lipoma 30.6 CDK4 MDM2
10 cellular myxoid liposarcoma 30.5 CDK4 MDM2
11 spindle cell liposarcoma 30.4 CDK4 MDM2
12 pleomorphic liposarcoma 30.1 CDKN2A MDM2 MUC1
13 ring chromosome 7 10.4 CDK4 MDM2
14 mesenchymoma 10.4 HMGA2 MDM2
15 undifferentiated embryonal sarcoma of the liver 10.4 CDK4 MDM2
16 embryonal sarcoma 10.4 CDK4 MDM2
17 cervical adenoma malignum 10.4 HMGA2 KRT7
18 malignant fibrous histiocytoma of bone 10.4 CDK4 MDM2
19 bone osteosarcoma 10.4 CDK4 MDM2
20 cornea cancer 10.4 CDK4 CDKN2A
21 cervical mucinous adenocarcinoma 10.4 HMGA2 KRT7
22 scrotal carcinoma 10.4 CDKN2A HMGA2
23 conventional leiomyosarcoma 10.4 CDKN2A HMGA2
24 mixed liposarcoma 10.4 CDK4 MDM2
25 periosteal osteogenic sarcoma 10.4 CDK4 MDM2
26 inverted transitional papilloma 10.4 CDKN2A KRT7
27 vulval paget's disease 10.3 CDKN2A KRT7
28 small cell sarcoma 10.3 CDK4 MDM2
29 adenoid basal cell carcinoma 10.3 CDKN2A KRT7
30 endocervical carcinoma 10.3 CDKN2A KRT7
31 bladder carcinoma in situ 10.3 CDKN2A KRT7
32 nasal cavity cancer 10.3 CDKN2A KRT7
33 vulvar disease 10.3 CDKN2A KRT7
34 nasal cavity adenocarcinoma 10.3 CDKN2A KRT7
35 vulva adenocarcinoma 10.3 CDKN2A KRT7
36 ewing's family of tumors 10.3 CDK4 CDKN2A
37 anal canal carcinoma 10.3 CDKN2A KRT7
38 glycogen-rich clear cell breast carcinoma 10.3 CDKN2A KRT7
39 malignant peritoneal mesothelioma 10.3 CDKN2A MUC1
40 peritoneal mesothelioma 10.3 CDKN2A MUC1
41 thymus lipoma 10.3 HMGA2 KRT7
42 solid adenocarcinoma with mucin production 10.3 KRT7 MUC1
43 endometrial mucinous adenocarcinoma 10.3 CDKN2A MUC1
44 endosalpingiosis 10.3 KRT7 MUC1
45 epithelial-myoepithelial carcinoma 10.3 HMGA2 KRT7
46 endocervical adenocarcinoma 10.3 CDKN2A KRT7
47 parachordoma 10.3 KRT7 MUC1
48 secretory meningioma 10.3 KRT7 MUC1
49 breast secretory carcinoma 10.3 CDK4 KRT7
50 bile duct mucoepidermoid carcinoma 10.3 KRT7 MUC1

Graphical network of the top 20 diseases related to Well-Differentiated Liposarcoma:



Diseases related to Well-Differentiated Liposarcoma

Symptoms & Phenotypes for Well-Differentiated Liposarcoma

Human phenotypes related to Well-Differentiated Liposarcoma:

60 33
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 60 33 hallmark (90%) Very frequent (99-80%) HP:0001482
2 abnormal renal physiology 60 33 occasional (7.5%) Occasional (29-5%) HP:0012211
3 gastrointestinal dysmotility 60 33 occasional (7.5%) Occasional (29-5%) HP:0002579

MGI Mouse Phenotypes related to Well-Differentiated Liposarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 CAVIN2 CDK4 CDKN2A DDR2 FRS2 MDM2

Drugs & Therapeutics for Well-Differentiated Liposarcoma

Search Clinical Trials , NIH Clinical Center for Well-Differentiated Liposarcoma

Genetic Tests for Well-Differentiated Liposarcoma

Anatomical Context for Well-Differentiated Liposarcoma

MalaCards organs/tissues related to Well-Differentiated Liposarcoma:

42
Testes, Tongue, Skin, Pancreas, Thyroid, Adrenal Gland

Publications for Well-Differentiated Liposarcoma

Articles related to Well-Differentiated Liposarcoma:

(show top 50) (show all 164)
# Title Authors Year
1
Orbital Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Masquerading as Pleomorphic Lipoma: A Diagnostic Challenge. ( 30908464 )
2019
2
Hypotrichosis with cone-rod dystrophy in a patient with cadherin 3 (CDH3) mutation. ( 30710256 )
2019
3
Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review. ( 30852045 )
2019
4
Macular Dystrophy and Cone-Rod Dystrophy Caused by Mutations in the RP1 Gene: Extending the RP1 Disease Spectrum. ( 30913292 )
2019
5
Amplification of FRS2 in atypical lipomatous tumour/well -differentiated liposarcoma and dedifferentiated liposarcoma: a clinicopathological and genetic study of 146 cases. ( 29368794 )
2018
6
Corrigendum to "Pericytic mimicry in well-differentiated liposarcoma/atypical lipomatous tumor" (Hum Pathol 2016;54:92-99). ( 29958690 )
2018
7
Well-Differentiated Liposarcoma (Atypical Lipomatous Tumor) Presenting as an Esophageal Polyp. ( 29349606 )
2018
8
The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center. ( 29723411 )
2018
9
Surgery for Abdominal Well-Differentiated Liposarcoma. ( 29335908 )
2018
10
Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma. ( 29372852 )
2018
11
Salvage Surgery for Recurrent Retroperitoneal Well-Differentiated Liposarcoma: Early Reoperation may not Provide Benefit. ( 29520652 )
2018
12
Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin. ( 29610390 )
2018
13
Progressive Cone Dystrophy and Cone-Rod Dystrophy (XL, AD, and AR). ( 30578485 )
2018
14
Well-Differentiated Liposarcoma Localized to the Thyroid Gland. ( 30374430 )
2018
15
ASO Author Reflections: Recurrent Retroperitoneal Well-Differentiated Liposarcoma. ( 30556116 )
2018
16
Spinal Metastasis of Well-Differentiated Liposarcoma Component in Retroperitoneal Dedifferentiated Liposarcoma Treated by Minimally Invasive Surgery. ( 30123596 )
2018
17
Fatty tumors of the retroperitoneum: Lipoma or well-differentiated liposarcoma. About a case of a giant retroperitoneal liposarcoma. ( 30211007 )
2018
18
A Well-Differentiated Liposarcoma in the Digit: A Case Report of the 5-Year Post-Surgical Follow-Up. ( 30282536 )
2018
19
Well-differentiated liposarcoma of the breast arising in a background of malignant phyllodes tumor in a pregnant woman: A rare case report and review of literature. ( 30303154 )
2018
20
CEP250 mutations associated with mild cone-rod dystrophy and sensorineural hearing loss in a Japanese family. ( 29718797 )
2018
21
Phenotypic diversity in autosomal-dominant cone-rod dystrophy elucidated by adaptive optics retinal imaging. ( 29074494 )
2018
22
NMNAT1 variants cause cone and cone-rod dystrophy. ( 29184169 )
2018
23
Ophthalmic features of cone-rod dystrophy caused by pathogenic variants in the ALMS1 gene. ( 29193673 )
2018
24
Clinical and genetic characteristics of 251 consecutive patients with macular and cone/cone-rod dystrophy. ( 29555955 )
2018
25
Progressive expansion of the hyperautofluorescent ring in cone-rod dystrophy patients. ( 29671671 )
2018
26
Novel variants identified with next-generation sequencing in Polish patients with cone-rod dystrophy. ( 29769798 )
2018
27
Multimodal Imaging in Autosomal Dominant Cone-Rod Dystrophy Caused by Novel CRX Variant. ( 30078014 )
2018
28
A novel CRX frameshift mutation causing cone-rod dystrophy in a Chinese family: A case report. ( 30095615 )
2018
29
Author Correction: Variabilities in retinal function and structure in a canine model of cone-rod dystrophy associated with RPGRIP1 support multigenic etiology. ( 30139995 )
2018
30
A novel p.(Glu111Val) missense mutation in GUCA1A associated with cone-rod dystrophy leads to impaired calcium sensing and perturbed second messenger homeostasis in photoreceptors. ( 30184081 )
2018
31
Primary atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) of the breast. ( 28845581 )
2017
32
Well-differentiated liposarcoma with chondroid metaplasia in the auricle of a dog. ( 28603215 )
2017
33
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature. ( 28634560 )
2017
34
Cavin-2 is a specific marker for detection of well-differentiated liposarcoma. ( 28865960 )
2017
35
Endoscopic submucosal dissection of a huge esophageal atypical lipomatous tumor (well-differentiated liposarcoma) with a 4-year recurrence-free survival. ( 28719927 )
2017
36
A novel sclerosing atypical lipomatous tumor/well-differentiated liposarcoma in a 7-year-old girl: Report of a case with molecular confirmation. ( 28705709 )
2017
37
Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review. ( 28377828 )
2017
38
Pedunculated, well differentiated liposarcoma of the oesophagus mimicking giant fibrovascular polyp. ( 28853590 )
2017
39
Well-differentiated Liposarcoma in a Bonnet Macaque (<i>Macaca radiata</i>). ( 28381318 )
2017
40
Concomitant organ resection does not improve outcomes in primary retroperitoneal well-differentiated liposarcoma: A retrospective cohort study at a major sarcoma center. ( 29228466 )
2017
41
Variabilities in retinal function and structure in a canine model of cone-rod dystrophy associated with RPGRIP1 support multigenic etiology. ( 28993665 )
2017
42
DIFFUSE RETINAL VASCULAR LEAKAGE AND CONE-ROD DYSTROPHY IN A FAMILY WITH THE HOMOZYGOUS MISSENSE C.1429G>A (P.GLY477ARG) MUTATION IN CRB1. ( 29200130 )
2017
43
Challenging differential diagnosis between lipoma and well-differentiated liposarcoma in the retroperitoneum. A case report. ( 27212576 )
2016
44
Can Abdominal Computed Tomography Imaging Help Accurately Identify a Dedifferentiated Component in a Well-Differentiated Liposarcoma? ( 27454788 )
2016
45
Well-differentiated liposarcoma of the floor of the mouth: Report of a rare case and review of the literature. ( 27601829 )
2016
46
Well-Differentiated Liposarcoma With Hibernoma-Like Morphology. ( 27272683 )
2016
47
Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry. ( 27597521 )
2016
48
Well differentiated liposarcoma, sclerosing type, of the pancreas a case report. ( 27840110 )
2016
49
Pericytic mimicry in well-differentiated liposarcoma / atypical lipomatous tumor. ( 27063472 )
2016
50
Heterologous Liposarcomatous Differentiation in Malignant Phyllodes Tumor is Histologically Similar but Immunohistochemically and Molecularly Distinct from Well-differentiated Liposarcoma of Soft Tissue. ( 26843318 )
2016

Variations for Well-Differentiated Liposarcoma

Expression for Well-Differentiated Liposarcoma

Search GEO for disease gene expression data for Well-Differentiated Liposarcoma.

Pathways for Well-Differentiated Liposarcoma

Pathways related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.88 CDK4 CDKN2A MDM2
2 11.75 CDK4 CDKN2A MDM2
3 11.38 CDK4 CDKN2A MDM2
4 11 CDK4 CDKN2A MDM2
5 10.66 CDKN2A MDM2
6
Show member pathways
10.6 CDKN2A MDM2
7 10.3 CDK4 CDKN2A MDM2

GO Terms for Well-Differentiated Liposarcoma

Cellular components related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 CDKN2A HMGA2

Biological processes related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 CDK4 DDR2 MDM2 TSPAN31
2 ventricular septum development GO:0003281 9.37 FRS2 MDM2
3 negative regulation of cell cycle arrest GO:0071157 9.32 CDK4 MDM2
4 positive regulation of cellular senescence GO:2000774 9.26 CDKN2A HMGA2
5 chondrocyte proliferation GO:0035988 9.16 DDR2 HMGA2
6 amyloid fibril formation GO:1990000 8.96 CDKN2A MDM2
7 senescence-associated heterochromatin focus assembly GO:0035986 8.62 CDKN2A HMGA2

Molecular functions related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SUMO transferase activity GO:0019789 8.62 CDKN2A MDM2

Sources for Well-Differentiated Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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