ALT
MCID: WLL039
MIFTS: 41

Well-Differentiated Liposarcoma (ALT)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Well-Differentiated Liposarcoma

MalaCards integrated aliases for Well-Differentiated Liposarcoma:

Name: Well-Differentiated Liposarcoma 12 58 15 17
Atypical Lipomatous Tumor 12 58 17
Atypical Lipoma 58 71
Liposarcoma, Well Differentiated 71
Pleomorphic Lipoma 71
Wdls 58
Alt 58

Characteristics:

Orphanet epidemiological data:

58
well-differentiated liposarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:5690
MeSH 43 D008080
NCIt 49 C4250
SNOMED-CT 67 28655007
ICD10 via Orphanet 33 C49.9
UMLS via Orphanet 72 C1370889
Orphanet 58 ORPHA99971
SNOMED-CT via HPO 68 39539005 95325000
UMLS 71 C0205823 C1266129 C1370889

Summaries for Well-Differentiated Liposarcoma

Disease Ontology : 12 A liposarcoma that is characterized as a slow growing, painless tumor usually located in the retroperitoneum or the limbs and derives from proliferating mature adipocytes.

MalaCards based summary : Well-Differentiated Liposarcoma, also known as atypical lipomatous tumor, is related to pleomorphic lipoma and soft tissue sarcoma. An important gene associated with Well-Differentiated Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Bladder cancer. The drugs Palbociclib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include adipocyte, breast and tongue, and related phenotypes are subcutaneous nodule and gastrointestinal dysmotility

Related Diseases for Well-Differentiated Liposarcoma

Diseases related to Well-Differentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 31.7 TSPAN31 SERPINA3 MDM2 HMGA2 CDK4 CD34
2 soft tissue sarcoma 31.4 MDM2 EWSR1
3 lipoblastoma 31.3 MDM2 CDK4
4 liposarcoma 31.3 TSPAN31 MDM2 HMGA2 FUS FRS2 EWSR1
5 inflammatory liposarcoma 31.3 MDM2 CDKN2A CD34
6 angiolipoma 31.2 MDM2 CD34
7 spindle cell lipoma 31.2 MDM2 CDK4 CD34
8 lipomatosis, multiple 31.2 TSPAN31 SERPINA3 MDM2 HMGA2 FUS EWSR1
9 infiltrating lipoma 31.1 MDM2 HMGA2 CDK4 CD34
10 juxtacortical osteosarcoma 31.1 MDM2 EWSR1 CDK4
11 fibrous histiocytoma 31.1 SERPINA3 FUS EWSR1 CD34
12 spindle cell liposarcoma 31.0 MDM2 DDIT3 CDK4 CD34
13 familial retinoblastoma 31.0 TSPAN31 MDM2 CDKN2A CDK4
14 sclerosing liposarcoma 31.0 MDM2 FUS CD34
15 ring chromosome 31.0 MDM2 HMGA2 EWSR1 CDK4
16 mediastinum liposarcoma 30.9 MDM2 CDKN2A CDK4
17 fibroma 30.9 SERPINA3 KRT7 CD34
18 spindle cell sarcoma 30.9 SERPINA3 MUC1 MDM2 KRT7 CD34
19 embryonal sarcoma 30.9 SERPINA3 MDM2 CDK4
20 mesenchymal cell neoplasm 30.8 SERPINA3 HMGA2 EWSR1 CD34
21 chondroid lipoma 30.8 HMGA2 CD34
22 myxoid liposarcoma 30.8 MDM2 HMGA2 HCCS FUS EWSR1 DDIT3
23 glomus tumor 30.8 MUC1 CDKN2A CD34
24 malignant mesenchymoma 30.7 SERPINA3 MDM2 CD34
25 malignant fibrous histiocytoma 30.6 SERPINA3 MUC1 MDM2 FUS EWSR1 DDIT3
26 angiosarcoma 30.6 MUC1 MDM2 KRT7 CD34
27 mixed liposarcoma 30.5 MDM2 FUS DDIT3 CDK4 CD34
28 chondrosarcoma 30.5 SERPINA3 MUC1 MDM2 EWSR1 CDK4
29 inflammatory myofibroblastic tumor 30.5 MUC1 MDM2 EWSR1 CDK4 CD34
30 leiomyosarcoma 30.5 SERPINA3 MUC1 MDM2 HMGA2 CDKN2A CDK4
31 myxofibrosarcoma 30.4 SERPINA3 MUC1 MDM2 FUS EWSR1 DDIT3
32 connective tissue benign neoplasm 30.4 SERPINA3 MDM2 EWSR1 CDK4 CD34
33 cellular myxoid liposarcoma 30.3 SERPINA3 MDM2 HCCS FUS EWSR1 DDIT3
34 pleomorphic liposarcoma 30.3 SERPINA3 MUC1 MDM2 HCCS FUS EWSR1
35 sarcoma 30.2 TSPAN31 SERPINA3 MUC1 MDM2 FUS EWSR1
36 dedifferentiated liposarcoma 29.9 TSPAN31 SERPINA3 MUC1 MIR100 MDM2 HMGA2
37 ring chromosome 7 10.7 MDM2 CDK4
38 cervical basaloid squamous cell carcinoma 10.7 KRT7 CDKN2A
39 inverted transitional papilloma 10.7 KRT7 CDKN2A
40 esophagus verrucous carcinoma 10.7 MDM2 CDKN2A
41 anal canal paget's disease 10.7 KRT7 CDKN2A
42 cervical adenoid cystic carcinoma 10.7 KRT7 CDKN2A
43 atrophic vulva 10.7 KRT7 CDKN2A
44 malignant peritoneal mesothelioma 10.7 MUC1 CDKN2A
45 diffuse lipomatosis 10.7 MDM2 CDK4
46 scrotum paget's disease 10.6 MUC1 KRT7
47 aortic malignant tumor 10.6 MDM2 CD34
48 hereditary melanoma 10.6 MDM2 CDKN2A CDK4
49 vulvar eccrine porocarcinoma 10.6 MUC1 CDKN2A
50 adult liposarcoma 10.6 MDM2 CDK4

Graphical network of the top 20 diseases related to Well-Differentiated Liposarcoma:



Diseases related to Well-Differentiated Liposarcoma

Symptoms & Phenotypes for Well-Differentiated Liposarcoma

Human phenotypes related to Well-Differentiated Liposarcoma:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482
2 gastrointestinal dysmotility 58 31 occasional (7.5%) Occasional (29-5%) HP:0002579
3 abnormal renal physiology 58 31 occasional (7.5%) Occasional (29-5%) HP:0012211

Drugs & Therapeutics for Well-Differentiated Liposarcoma

Drugs for Well-Differentiated Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palbociclib Approved, Investigational Phase 2 571190-30-2 5005498 11431660 5330286
2 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Single Arm Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well-Differentiated or Dedifferentiated Liposarcoma Unknown status NCT03096912 Phase 2 Ribociclib
2 A Phase II Single Arm Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well-Differentiated or Dedifferentiated Liposarcoma Unknown status NCT02571829 Phase 2 ribociclib
3 Phase II Clinical Trial of Pazopanib to Evaluate the Activity and Tolerability in Patients With Advanced and/or Metastatic Liposarcoma Who Have Relapsed Following Standard Therapies or for Whom no Standard Therapy Exists Completed NCT01692496 Phase 2 Pazopanib
4 A Phase II Study of CDK4/6 Inhibition (Palbociclib) Combined With PD-1 Blockade (INCMGA00012) in Patients With Advanced Well-differentiated and/or Dedifferentiated Liposarcoma Recruiting NCT04438824 Phase 2 INCMGA00012;Palbociclib
5 Efficacy and Safety of Plitidepsin in Patients With Advanced Unresectable or Metastatic, Relapsed/Refractory, Dedifferentiated Liposarcoma (DLPS): an Exploratory Phase II Multicenter Trial Terminated NCT01876043 Phase 2 plitidepsin
6 The FGF/FGFR Signalling Pathway: a Novel Therapeutic Target in Liposarcomas Recruiting NCT03303885
7 REtroperitoneal SArcoma Registry (RESAR): Prospective Collection of Primary Retroperitoneal Sarcoma Patient's Data, Radiological and Pathological Material for the TransAtlantic Retroperitoneal Sarcoma Working Group Recruiting NCT03838718
8 Identification of a New Blood Biomarker for the Diagnosis and Prognosis of Liposarcomas Not yet recruiting NCT04224064

Search NIH Clinical Center for Well-Differentiated Liposarcoma

Genetic Tests for Well-Differentiated Liposarcoma

Anatomical Context for Well-Differentiated Liposarcoma

MalaCards organs/tissues related to Well-Differentiated Liposarcoma:

40
Adipocyte, Breast, Tongue, Bone, Colon, Skin, Smooth Muscle

Publications for Well-Differentiated Liposarcoma

Articles related to Well-Differentiated Liposarcoma:

(show top 50) (show all 885)
# Title Authors PMID Year
1
Qualitative evaluation of MRI features of lipoma and atypical lipomatous tumor: results from a multicenter study. 61
31965239 2020
2
An MRI-based decision tree to distinguish lipomas and lipoma variants from well-differentiated liposarcoma of the extremity and superficial trunk: Classification and regression tree (CART) analysis. 61
32339981 2020
3
Quantitative signal intensity ratios to distinguish between subfascial lipoma and atypical lipomatous tumor/well-differentiated liposarcoma using short-tau inversion recovery (STIR) MRI. 61
32107197 2020
4
Parosteal osteosarcoma associated with a low-grade component mimicking well-differentiated liposarcoma: a case report. 61
32564106 2020
5
Usefulness of laparoscopy in the management of incidentally discovered retroperitoneal liposarcoma mimicking inguinal hernia: A case report and literature review. 61
32516702 2020
6
Molecular Characterization of a Rare Dedifferentiated Liposarcoma With Rhabdomyosarcomatous Differentiation in a 24 Year Old. 61
31801397 2020
7
Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature. 61
31995237 2020
8
Rare MDM2 amplification in a fat-predominant angiomyolipoma. 61
32409886 2020
9
Dedifferentiated Liposarcoma With Meningothelial-Like Whorls: Five Additional Cases and Review of the Literature. 61
32419561 2020
10
Low-grade Osteosarcomatous Dedifferentiation of an Atypical Lipomatous Tumor in a Pediatric Patient. 61
31739757 2020
11
Pilot study to differentiate lipoma from atypical lipomatous tumour/well-differentiated liposarcoma using MR radiomics-based texture analysis. 61
32424704 2020
12
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma With Features Mimicking Spindle Cell Lipoma. 61
31672072 2020
13
Dysplastic lipoma: potential diagnostic pitfall of using MDM2 RNA in situ hybridization to distinguish between lipoma and atypical lipomatous tumor. 61
32439322 2020
14
Well-differentiated liposarcoma disguised as a recurrent lipoma of the forearm flexor compartment: A case report. 61
32534416 2020
15
Primary Well-Differentiated Liposarcoma of the Orbit. 61
32450731 2020
16
Surgical management of truncal and extremities atypical lipomatous tumors/well-differentiated liposarcoma: A systematic review of the literature. 61
32029218 2020
17
Evaluating the Impact of Surveillance Follow-Up Intervals in Patients Following Resection of Primary Well-Differentiated Liposarcoma of the Retroperitoneum. 61
32409969 2020
18
ASO Author Reflections: Surveillance After Resection of Retroperitoneal Well-Differentiated Liposarcoma: A Balancing Act Between Earlier Recurrence Detection, Patient Anxiety, and Health Care Resource Expenditure. 61
32409970 2020
19
A Diagnostic Dilemma of a Subcutaneous Hibernoma: Case Report. 61
32332693 2020
20
From head and neck lipoma to liposarcoma: a wide spectrum of differential diagnoses and their therapeutic implications. 61
32011399 2020
21
An evidence-based guideline on the application of molecular testing in the diagnosis, prediction of prognosis, and selection of therapy in non-GIST soft tissue sarcomas. 61
32092619 2020
22
Correlation between percutaneous biopsy and final histopathology for retroperitoneal sarcoma: a single-centre study. 61
32064728 2020
23
Primary gastrointestinal liposarcoma-a clinicopathological study of 8 cases of a rare entity. 61
31884085 2020
24
[Case of Resected Retroperitoneal Dedifferentiated Liposarcoma Extending to the Posterior Mediastinum]. 61
32381938 2020
25
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma with Myxoid Stroma in a Hereditary Retinoblastoma Survivor. 61
32258014 2020
26
The Utility of Perilipin in Liposarcomas: PLIN1 Differentiates Round Cell Liposarcoma From Other Round Cell Sarcomas. 61
32205741 2020
27
Oral liposarcoma in elderly: Case report and literature analysis. 61
32028409 2020
28
[Resection of soft tissue tumours : Pitfalls, typical complications and prevention strategies]. 61
31974631 2020
29
Paratesticular well-differentiated liposarcoma initially diagnosed as fibrous pseudotumour. 61
32108629 2020
30
[A Case of Retroperitoneal Primary Well-Differentiated Liposarcoma Treated by Laparoscopic Surgery]. 61
32381978 2020
31
MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma. 61
31971976 2020
32
Gluteal liposarcoma presenting as sciatic hernia: A case report and review of literature. 61
32006905 2020
33
PET/CT Imaging as a Diagnostic Tool in Distinguishing Well-Differentiated versus Dedifferentiated Liposarcoma. 61
32565716 2020
34
The Role of Tc-99m DTPA Renal Dynamic Scintigraphy in Retroperitoneal Liposarcoma. 61
32185230 2020
35
What's new in adipocytic neoplasia? 61
31501988 2020
36
Lipomatous Tumors in Pediatric Patients: A Retrospective Analysis of 50 cases. 61
31282548 2020
37
Diagnostic importance of clinicopathologic features and p16, CD34, MDM2 expression in differential diagnosis of adipocytic tumors. 61
32175898 2020
38
Radiomics approach to distinguish between well differentiated liposarcomas and lipomas on MRI. 61
31747074 2019
39
Para-anal lipoma as a rare consequence to perineal trauma. Case-report and review of the literature. 61
29734868 2019
40
Primary Sarcomas of the Larynx: A Single Institutional Experience with Ten Cases. 61
31813100 2019
41
Atypical lipomatous tumour/well-differentiated liposarcoma and de-differentiated liposarcoma in patients aged ≤ 40 years: a study of 116 patients. 61
31471922 2019
42
ASO Author Reflections: Recurrent Retroperitoneal Well-Differentiated Liposarcoma. 61
30556116 2019
43
"Fat-Rich" (Spindle Cell-Poor) Variant of Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: Striking Mimic of "Classical" Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma. 61
31131655 2019
44
Deep-seated Hibernoma of Thigh: A Rare Benign Adipocytic Tumor. 61
31779762 2019
45
Surgical treatment for giant retroperitoneal well-differentiated liposarcoma (WDLPS): case report and literature review. 61
32007117 2019
46
Diagnostic Utility and Limitations of Immunohistochemistry of p16, CDK4, and MDM2 and Automated Dual-color In Situ Hybridization of MDM2 for the Diagnosis of Challenging Cases of Dedifferentiated Liposarcoma. 61
31145104 2019
47
Coexistance of a well differentiated liposarcoma and dedifferentiated low grade myxofibrosarcoma of the scrotum. A rare case and review of the literature. 61
32007114 2019
48
Concurrent bariatric surgery and surgical resection of massive localized lymphedema of the thigh. A case report. 61
31687133 2019
49
The transition of tissue inhibitor of metalloproteinases from -4 to -1 induces aggressive behavior and poor patient survival in dedifferentiated liposarcoma via YAP/TAZ activation. 61
31074490 2019
50
Advances in soft-tissue sarcoma - There are no mistakes, only lessons to learn! 61
31807494 2019

Variations for Well-Differentiated Liposarcoma

Expression for Well-Differentiated Liposarcoma

Search GEO for disease gene expression data for Well-Differentiated Liposarcoma.

Pathways for Well-Differentiated Liposarcoma

Pathways related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.3 MDM2 HMGA2 FUS EWSR1 DDIT3
2 11.2 MDM2 CDKN2A CDK4
3 10.64 MDM2 CDKN2A CDK4

GO Terms for Well-Differentiated Liposarcoma

Cellular components related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 HMGA2 CDKN2A

Biological processes related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid fibril formation GO:1990000 9.16 MDM2 CDKN2A
2 chondrocyte proliferation GO:0035988 8.96 HMGA2 DDR2
3 senescence-associated heterochromatin focus assembly GO:0035986 8.62 HMGA2 CDKN2A

Molecular functions related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription coregulator activity GO:0003712 8.92 MUC1 HMGA2 FUS EWSR1

Sources for Well-Differentiated Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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