MCID: WLL039
MIFTS: 40

Well-Differentiated Liposarcoma

Categories: Rare diseases

Aliases & Classifications for Well-Differentiated Liposarcoma

MalaCards integrated aliases for Well-Differentiated Liposarcoma:

Name: Well-Differentiated Liposarcoma 59
Atypical Lipoma 59 73
Liposarcoma, Well Differentiated 73
Atypical Lipomatous Tumor 59
Pleomorphic Lipoma 73
Wdls 59
Alt 59

Characteristics:

Orphanet epidemiological data:

59
well-differentiated liposarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Orphanet 59 ORPHA99971
ICD10 via Orphanet 34 C49.9
UMLS via Orphanet 74 C1370889
SNOMED-CT via HPO 69 95325000 39539005
UMLS 73 C1266129

Summaries for Well-Differentiated Liposarcoma

MalaCards based summary : Well-Differentiated Liposarcoma, also known as atypical lipoma, is related to spindle cell lipoma and myxoid liposarcoma. An important gene associated with Well-Differentiated Liposarcoma is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are DNA Damage Response and Cell cycle. The drugs Rosiglitazone and Maleic acid have been mentioned in the context of this disorder. Affiliated tissues include testes, pancreas and adrenal gland, and related phenotypes are subcutaneous nodule and abnormal renal physiology

Related Diseases for Well-Differentiated Liposarcoma

Diseases related to Well-Differentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 spindle cell lipoma 31.0 CDK4 MDM2
2 myxoid liposarcoma 30.7 CDK4 HMGA2 MDM2
3 infiltrating lipoma 30.5 CDK4 HMGA2 MDM2
4 pleomorphic lipoma 30.5 CDK4 HMGA2 MDM2
5 liposarcoma 30.3 CDK4 CDKN2A HMGA2 MDM2 TSPAN31
6 dedifferentiated liposarcoma 29.8 CDK4 CDKN2A HMGA2 MDM2 MUC1
7 atypical lipomatous tumor 29.8 CDK4 CDKN2A HMGA2 MDM2 TSPAN31
8 mesenchymoma 10.8 HMGA2 MDM2
9 ring chromosome 7 10.8 CDK4 MDM2
10 undifferentiated embryonal sarcoma of the liver 10.8 CDK4 MDM2
11 inflammatory mfh 10.8 CDK4 MDM2
12 bone osteosarcoma 10.8 CDK4 MDM2
13 lipoblastoma 10.8 CDK4 MDM2
14 conventional leiomyosarcoma 10.8 CDKN2A HMGA2
15 mixed liposarcoma 10.8 CDK4 MDM2
16 malignant fibrous histiocytoma of bone 10.8 CDK4 MDM2
17 scrotal carcinoma 10.8 CDKN2A HMGA2
18 spindle cell liposarcoma 10.7 CDK4 MDM2
19 periosteal osteogenic sarcoma 10.7 CDK4 MDM2
20 small cell sarcoma 10.7 CDK4 MDM2
21 malignant peritoneal mesothelioma 10.7 CDKN2A MUC1
22 cervical adenoma malignum 10.7 HMGA2 KRT7
23 endometrial mucinous adenocarcinoma 10.7 CDKN2A MUC1
24 juxtacortical osteosarcoma 10.7 CDK4 MDM2
25 ewing's family of tumors 10.7 CDK4 CDKN2A
26 cervical mucinous adenocarcinoma 10.7 HMGA2 KRT7
27 cholangiolocellular carcinoma 10.7 CDKN2A MUC1
28 anaplastic ependymoma 10.7 MDM2 MUC1
29 embryonal sarcoma 10.6 CDK4 MDM2
30 sarcomatoid mesothelioma 10.6 CDKN2A MUC1
31 inverted transitional papilloma 10.6 CDKN2A KRT7
32 plasmablastic lymphoma 10.6 CDKN2A MUC1
33 endocervical carcinoma 10.6 CDKN2A KRT7
34 vulval paget's disease 10.6 CDKN2A KRT7
35 solid adenocarcinoma with mucin production 10.6 KRT7 MUC1
36 adenoid basal cell carcinoma 10.6 CDKN2A KRT7
37 bladder carcinoma in situ 10.6 CDKN2A KRT7
38 meningeal melanocytoma 10.6 CDKN2A MUC1
39 endosalpingiosis 10.6 KRT7 MUC1
40 parachordoma 10.6 KRT7 MUC1
41 nasal cavity adenocarcinoma 10.6 CDKN2A KRT7
42 bile duct mucoepidermoid carcinoma 10.6 KRT7 MUC1
43 middle ear adenoma 10.6 KRT7 MUC1
44 vulva adenocarcinoma 10.6 CDKN2A KRT7
45 malignant mixed mullerian tumor 10.6 KRT7 MUC1
46 nodular hidradenoma 10.6 KRT7 MUC1
47 glycogen-rich clear cell breast carcinoma 10.5 CDKN2A KRT7
48 immune system organ benign neoplasm 10.5 HMGA2 KRT7
49 bile duct cystadenocarcinoma 10.5 KRT7 MUC1
50 hemangiopericytoma, malignant 10.5 MDM2 MUC1

Graphical network of the top 20 diseases related to Well-Differentiated Liposarcoma:



Diseases related to Well-Differentiated Liposarcoma

Symptoms & Phenotypes for Well-Differentiated Liposarcoma

Human phenotypes related to Well-Differentiated Liposarcoma:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001482
2 abnormal renal physiology 59 32 occasional (7.5%) Occasional (29-5%) HP:0012211
3 gastrointestinal dysmotility 59 32 occasional (7.5%) Occasional (29-5%) HP:0002579

Drugs & Therapeutics for Well-Differentiated Liposarcoma

Drugs for Well-Differentiated Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
2
Maleic acid Experimental Phase 2 110-16-7 444266
3 Hypoglycemic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Activity and Tolerability of Pazopanib in Advanced and/or Metastatic Liposarcoma. A Phase II Clinical Trial Unknown status NCT01692496 Phase 2 Pazopanib
2 Rosiglitazone in Treating Patients With Liposarcoma Completed NCT00004180 Phase 2 rosiglitazone maleate
3 A Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well/Dedifferentiated Liposarcoma Recruiting NCT03096912 Phase 2 Ribociclib
4 Efficacy and Safety of Plitidepsin in Patients With Advanced Unresectable or Metastatic, Relapsed/Refractory, Dedifferentiated Liposarcoma (DLPS): an Exploratory Phase II Multicenter Trial Terminated NCT01876043 Phase 2 plitidepsin
5 The FGF/FGFR Signalling Pathway: Recruiting NCT03303885

Search NIH Clinical Center for Well-Differentiated Liposarcoma

Genetic Tests for Well-Differentiated Liposarcoma

Anatomical Context for Well-Differentiated Liposarcoma

MalaCards organs/tissues related to Well-Differentiated Liposarcoma:

41
Testes, Pancreas, Adrenal Gland

Publications for Well-Differentiated Liposarcoma

Articles related to Well-Differentiated Liposarcoma:

(show top 50) (show all 97)
# Title Authors Year
1
Amplification of FRS2 in atypical lipomatous tumour/well -differentiated liposarcoma and dedifferentiated liposarcoma: a clinicopathological and genetic study of 146 cases. ( 29368794 )
2018
2
Corrigendum to "Pericytic mimicry in well-differentiated liposarcoma/atypical lipomatous tumor" (Hum Pathol 2016;54:92-99). ( 29958690 )
2018
3
Well-Differentiated Liposarcoma (Atypical Lipomatous Tumor) Presenting as an Esophageal Polyp. ( 29349606 )
2018
4
The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center. ( 29723411 )
2018
5
Surgery for Abdominal Well-Differentiated Liposarcoma. ( 29335908 )
2018
6
Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma. ( 29372852 )
2018
7
Salvage Surgery for Recurrent Retroperitoneal Well-Differentiated Liposarcoma: Early Reoperation may not Provide Benefit. ( 29520652 )
2018
8
Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin. ( 29610390 )
2018
9
Primary atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) of the breast. ( 28845581 )
2017
10
Well-differentiated liposarcoma with chondroid metaplasia in the auricle of a dog. ( 28603215 )
2017
11
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature. ( 28634560 )
2017
12
Cavin-2 is a specific marker for detection of well-differentiated liposarcoma. ( 28865960 )
2017
13
Endoscopic submucosal dissection of a huge esophageal atypical lipomatous tumor (well-differentiated liposarcoma) with a 4-year recurrence-free survival. ( 28719927 )
2017
14
A novel sclerosing atypical lipomatous tumor/well-differentiated liposarcoma in a 7-year-old girl: Report of a case with molecular confirmation. ( 28705709 )
2017
15
Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review. ( 28377828 )
2017
16
Pedunculated, well differentiated liposarcoma of the oesophagus mimicking giant fibrovascular polyp. ( 28853590 )
2017
17
Well-differentiated Liposarcoma in a Bonnet Macaque (<i>Macaca radiata</i>). ( 28381318 )
2017
18
Concomitant organ resection does not improve outcomes in primary retroperitoneal well-differentiated liposarcoma: A retrospective cohort study at a major sarcoma center. ( 29228466 )
2017
19
Challenging differential diagnosis between lipoma and well-differentiated liposarcoma in the retroperitoneum. A case report. ( 27212576 )
2016
20
Can Abdominal Computed Tomography Imaging Help Accurately Identify a Dedifferentiated Component in a Well-Differentiated Liposarcoma? ( 27454788 )
2016
21
Well-differentiated liposarcoma of the floor of the mouth: Report of a rare case and review of the literature. ( 27601829 )
2016
22
Well-Differentiated Liposarcoma With Hibernoma-Like Morphology. ( 27272683 )
2016
23
Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry. ( 27597521 )
2016
24
Well differentiated liposarcoma, sclerosing type, of the pancreas a case report. ( 27840110 )
2016
25
Pericytic mimicry in well-differentiated liposarcoma / atypical lipomatous tumor. ( 27063472 )
2016
26
Giant Cervico-mediastinal Well-differentiated Liposarcoma. ( 25837020 )
2015
27
Intramuscular atypical lipomatous tumor/well-differentiated liposarcoma of the pectoralis major masquerading as a breast tumor: management and review of the literature. ( 25692417 )
2015
28
Primary well-differentiated liposarcoma of the eyelid clinically masquerading as a benign tumour: a rare entity confirmed by murine double minute 2 fluorescence in-situ hybridization. ( 25753497 )
2015
29
Vulvar Myxoid Liposarcoma and Well Differentiated Liposarcoma With Molecular Cytogenetic Confirmation: Case Reports With Review of Malignant Lipomatous Tumors of the Vulva. ( 25851712 )
2015
30
Atypical lipomatous tumor/well-differentiated liposarcoma of the gingiva: a case report and review of literature. ( 23992781 )
2014
31
Well differentiated liposarcoma of spermatic cord: report of 3 rare cases. ( 25250255 )
2014
32
CDK4 amplification predicts recurrence of well-differentiated liposarcoma of the abdomen. ( 25121597 )
2014
33
D-dimer levels in the differential diagnosis between lipoma and well-differentiated liposarcoma. ( 25202112 )
2014
34
FDG PET/CT findings in a rare case of giant fibrovascular polyp of the esophagus harboring atypical lipomatous tumor/well-differentiated liposarcoma. ( 24458178 )
2014
35
Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements. ( 24505276 )
2014
36
Estrogen receptor alpha and androgen receptor are commonly expressed in well-differentiated liposarcoma. ( 25349530 )
2014
37
Can Experienced Observers Differentiate between Lipoma and Well-Differentiated Liposarcoma Using Only MRI? ( 24385845 )
2013
38
MRI characteristics of lipoma and atypical lipomatous tumor/well-differentiated liposarcoma: retrospective comparison with histology and MDM2 gene amplification. ( 22987247 )
2013
39
Giant inflammatory variant of well differentiated liposarcoma: a case report of a rare entity. ( 24086890 )
2013
40
Incidental lipoma-like hibernoma arising from the adrenal gland: a well-differentiated liposarcoma mimicker. ( 24002005 )
2013
41
Giant inflammatory variant of well-differentiated liposarcoma of retroperitoneum: a rare case report. ( 24426736 )
2013
42
Cyclin-dependent kinase inhibitor 2A (p16) distinguishes well-differentiated liposarcoma from lipoma. ( 23600700 )
2013
43
Deep-seated huge hibernoma of soft tissue: a rare differential diagnosis of atypical lipomatous tumor/well differentiated liposarcoma. ( 24133596 )
2013
44
Sclerosing variant of well-differentiated liposarcoma: relative prevalence and spectrum of CT and MRI features. ( 23789670 )
2013
45
Dedifferentiated liposarcoma with lipoma-like well-differentiated liposarcoma: clinicopathological study of 30 cases, with particular attention to the comingling pattern of well- and dedifferentiated components: a proposal for regrouping of the present subclassification of well-differentiated liposarcoma and dedifferentiated liposarcoma. ( 22674916 )
2013
46
Giant Atypical Lipoma of the Thigh. ( 24354663 )
2013
47
Giant gastric lipoma mimicking well-differentiated liposarcoma. ( 23308321 )
2012
48
A rare case of primary parapharyngeal well differentiated liposarcoma with rhabdomyoblastic differentiation. ( 23285457 )
2012
49
Atypical lipomatous tumor/well-differentiated liposarcoma: what is it? ( 22365523 )
2012
50
Predicting survival for well-differentiated liposarcoma: the importance of tumor location. ( 21920555 )
2012

Variations for Well-Differentiated Liposarcoma

Expression for Well-Differentiated Liposarcoma

Search GEO for disease gene expression data for Well-Differentiated Liposarcoma.

Pathways for Well-Differentiated Liposarcoma

Pathways related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12 CDK4 CDKN2A MDM2
2 11.97 CDK4 CDKN2A MDM2
3 11.88 CDK4 CDKN2A MDM2
4 11.64 CDK4 CDKN2A MDM2
5 11.38 CDK4 CDKN2A MDM2
6 11 CDK4 CDKN2A MDM2
7 10.71 CDKN2A MDM2
8
Show member pathways
10.66 CDKN2A MDM2
9 10.3 CDK4 CDKN2A MDM2

GO Terms for Well-Differentiated Liposarcoma

Cellular components related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 CDKN2A HMGA2

Biological processes related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 CDK4 DDR2 MDM2 TSPAN31
2 negative regulation of cell cycle arrest GO:0071157 9.37 CDK4 MDM2
3 positive regulation of cellular senescence GO:2000774 9.32 CDKN2A HMGA2
4 chondrocyte proliferation GO:0035988 9.26 DDR2 HMGA2
5 amyloid fibril formation GO:1990000 9.16 CDKN2A MDM2
6 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 8.96 CDK4 CDKN2A
7 senescence-associated heterochromatin focus assembly GO:0035986 8.62 CDKN2A HMGA2

Molecular functions related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 8.96 CDKN2A MDM2
2 SUMO transferase activity GO:0019789 8.62 CDKN2A MDM2

Sources for Well-Differentiated Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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