ALT
MCID: WLL039
MIFTS: 40

Well-Differentiated Liposarcoma (ALT)

Categories: Rare diseases

Aliases & Classifications for Well-Differentiated Liposarcoma

MalaCards integrated aliases for Well-Differentiated Liposarcoma:

Name: Well-Differentiated Liposarcoma 59
Atypical Lipoma 59 73
Liposarcoma, Well Differentiated 73
Atypical Lipomatous Tumor 59
Pleomorphic Lipoma 73
Wdls 59
Alt 59

Characteristics:

Orphanet epidemiological data:

59
well-differentiated liposarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Orphanet 59 ORPHA99971
ICD10 via Orphanet 34 C49.9
UMLS via Orphanet 74 C1370889
SNOMED-CT via HPO 69 95325000 39539005

Summaries for Well-Differentiated Liposarcoma

MalaCards based summary : Well-Differentiated Liposarcoma, also known as atypical lipoma, is related to liposarcoma and atypical lipomatous tumor. An important gene associated with Well-Differentiated Liposarcoma is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are Viral carcinogenesis and Cellular senescence (KEGG). Affiliated tissues include lung, skin and liver, and related phenotypes are subcutaneous nodule and abnormal renal physiology

Related Diseases for Well-Differentiated Liposarcoma

Diseases related to Well-Differentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 liposarcoma 31.4 CDK4 CDKN2A HMGA2 MDM2 TSPAN31
2 atypical lipomatous tumor 30.9 CDK4 CDKN2A HMGA2 MDM2 TSPAN31
3 dedifferentiated liposarcoma 30.7 CDK4 CDKN2A HMGA2 MDM2
4 pleomorphic lipoma 30.6 HMGA2 MDM2
5 lipoblastoma 30.4 CDK4 MDM2
6 infiltrating lipoma 30.4 CDK4 HMGA2 MDM2
7 myxoid liposarcoma 30.4 CDK4 HMGA2 MDM2
8 spindle cell lipoma 30.3 CDK4 MDM2
9 cellular myxoid liposarcoma 30.3 CDK4 MDM2
10 spindle cell liposarcoma 30.2 CDK4 MDM2
11 lipomatosis, multiple 30.2 CDK4 HMGA2 MDM2
12 pleomorphic liposarcoma 29.9 CDKN2A MDM2 MUC1
13 ring chromosome 7 10.3 CDK4 MDM2
14 mesenchymoma 10.3 HMGA2 MDM2
15 undifferentiated embryonal sarcoma of the liver 10.3 CDK4 MDM2
16 embryonal sarcoma 10.3 CDK4 MDM2
17 malignant fibrous histiocytoma of bone 10.3 CDK4 MDM2
18 bone osteosarcoma 10.2 CDK4 MDM2
19 scrotal carcinoma 10.2 CDKN2A HMGA2
20 conventional leiomyosarcoma 10.2 CDKN2A HMGA2
21 cornea cancer 10.2 CDK4 CDKN2A
22 mixed liposarcoma 10.2 CDK4 MDM2
23 cervical adenoma malignum 10.2 HMGA2 KRT7
24 periosteal osteogenic sarcoma 10.2 CDK4 MDM2
25 cervical mucinous adenocarcinoma 10.2 HMGA2 KRT7
26 inverted transitional papilloma 10.2 CDKN2A KRT7
27 small cell sarcoma 10.2 CDK4 MDM2
28 vulval paget's disease 10.2 CDKN2A KRT7
29 adenoid basal cell carcinoma 10.2 CDKN2A KRT7
30 endocervical carcinoma 10.2 CDKN2A KRT7
31 ewing's family of tumors 10.2 CDK4 CDKN2A
32 bladder carcinoma in situ 10.2 CDKN2A KRT7
33 nasal cavity cancer 10.2 CDKN2A KRT7
34 vulvar disease 10.2 CDKN2A KRT7
35 nasal cavity adenocarcinoma 10.2 CDKN2A KRT7
36 vulva adenocarcinoma 10.2 CDKN2A KRT7
37 anal canal carcinoma 10.2 CDKN2A KRT7
38 glycogen-rich clear cell breast carcinoma 10.2 CDKN2A KRT7
39 angiomyolipoma 10.2
40 thymus lipoma 10.2 HMGA2 KRT7
41 endocervical adenocarcinoma 10.2 CDKN2A KRT7
42 epithelial-myoepithelial carcinoma 10.2 HMGA2 KRT7
43 verrucous carcinoma 10.2 CDKN2A MDM2
44 breast secretory carcinoma 10.2 CDK4 KRT7
45 immune system organ benign neoplasm 10.2 HMGA2 KRT7
46 malignant peritoneal mesothelioma 10.2 CDKN2A MUC1
47 peritoneal mesothelioma 10.2 CDKN2A MUC1
48 necrotizing sialometaplasia 10.2 CDKN2A KRT7
49 endometrial mucinous adenocarcinoma 10.2 CDKN2A MUC1
50 infiltrating angiolipoma 10.2 CDK4 CDKN2A MDM2

Graphical network of the top 20 diseases related to Well-Differentiated Liposarcoma:



Diseases related to Well-Differentiated Liposarcoma

Symptoms & Phenotypes for Well-Differentiated Liposarcoma

Human phenotypes related to Well-Differentiated Liposarcoma:

59 32
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 59 32 hallmark (90%) Very frequent (99-80%) HP:0001482
2 abnormal renal physiology 59 32 occasional (7.5%) Occasional (29-5%) HP:0012211
3 gastrointestinal dysmotility 59 32 occasional (7.5%) Occasional (29-5%) HP:0002579

MGI Mouse Phenotypes related to Well-Differentiated Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 CAVIN2 CDK4 CDKN2A DDR2 FRS2 MDM2

Drugs & Therapeutics for Well-Differentiated Liposarcoma

Search Clinical Trials , NIH Clinical Center for Well-Differentiated Liposarcoma

Genetic Tests for Well-Differentiated Liposarcoma

Anatomical Context for Well-Differentiated Liposarcoma

MalaCards organs/tissues related to Well-Differentiated Liposarcoma:

41
Lung, Skin, Liver, Bone, Ovary, Tonsil, Thymus

Publications for Well-Differentiated Liposarcoma

Articles related to Well-Differentiated Liposarcoma:

(show top 50) (show all 155)
# Title Authors Year
1
Amplification of FRS2 in atypical lipomatous tumour/well -differentiated liposarcoma and dedifferentiated liposarcoma: a clinicopathological and genetic study of 146 cases. ( 29368794 )
2018
2
Corrigendum to "Pericytic mimicry in well-differentiated liposarcoma/atypical lipomatous tumor" (Hum Pathol 2016;54:92-99). ( 29958690 )
2018
3
Well-Differentiated Liposarcoma (Atypical Lipomatous Tumor) Presenting as an Esophageal Polyp. ( 29349606 )
2018
4
The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center. ( 29723411 )
2018
5
Surgery for Abdominal Well-Differentiated Liposarcoma. ( 29335908 )
2018
6
Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma. ( 29372852 )
2018
7
Salvage Surgery for Recurrent Retroperitoneal Well-Differentiated Liposarcoma: Early Reoperation may not Provide Benefit. ( 29520652 )
2018
8
Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin. ( 29610390 )
2018
9
Spinal Metastasis of Well-Differentiated Liposarcoma Component in Retroperitoneal Dedifferentiated Liposarcoma Treated by Minimally Invasive Surgery. ( 30123596 )
2018
10
Fatty tumors of the retroperitoneum: Lipoma or well-differentiated liposarcoma. About a case of a giant retroperitoneal liposarcoma. ( 30211007 )
2018
11
A Well-Differentiated Liposarcoma in the Digit: A Case Report of the 5-Year Post-Surgical Follow-Up. ( 30282536 )
2018
12
Well-differentiated liposarcoma of the breast arising in a background of malignant phyllodes tumor in a pregnant woman: A rare case report and review of literature. ( 30303154 )
2018
13
Well-Differentiated Liposarcoma Localized to the Thyroid Gland. ( 30374430 )
2018
14
ASO Author Reflections: Recurrent Retroperitoneal Well-Differentiated Liposarcoma. ( 30556116 )
2018
15
Primary atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) of the breast. ( 28845581 )
2017
16
Well-differentiated liposarcoma with chondroid metaplasia in the auricle of a dog. ( 28603215 )
2017
17
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature. ( 28634560 )
2017
18
Cavin-2 is a specific marker for detection of well-differentiated liposarcoma. ( 28865960 )
2017
19
Endoscopic submucosal dissection of a huge esophageal atypical lipomatous tumor (well-differentiated liposarcoma) with a 4-year recurrence-free survival. ( 28719927 )
2017
20
A novel sclerosing atypical lipomatous tumor/well-differentiated liposarcoma in a 7-year-old girl: Report of a case with molecular confirmation. ( 28705709 )
2017
21
Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review. ( 28377828 )
2017
22
Pedunculated, well differentiated liposarcoma of the oesophagus mimicking giant fibrovascular polyp. ( 28853590 )
2017
23
Well-differentiated Liposarcoma in a Bonnet Macaque (<i>Macaca radiata</i>). ( 28381318 )
2017
24
Concomitant organ resection does not improve outcomes in primary retroperitoneal well-differentiated liposarcoma: A retrospective cohort study at a major sarcoma center. ( 29228466 )
2017
25
Giant atypical lipoma. ( 28954109 )
2017
26
Challenging differential diagnosis between lipoma and well-differentiated liposarcoma in the retroperitoneum. A case report. ( 27212576 )
2016
27
Can Abdominal Computed Tomography Imaging Help Accurately Identify a Dedifferentiated Component in a Well-Differentiated Liposarcoma? ( 27454788 )
2016
28
Well-differentiated liposarcoma of the floor of the mouth: Report of a rare case and review of the literature. ( 27601829 )
2016
29
Well-Differentiated Liposarcoma With Hibernoma-Like Morphology. ( 27272683 )
2016
30
Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry. ( 27597521 )
2016
31
Well differentiated liposarcoma, sclerosing type, of the pancreas a case report. ( 27840110 )
2016
32
Pericytic mimicry in well-differentiated liposarcoma / atypical lipomatous tumor. ( 27063472 )
2016
33
Heterologous Liposarcomatous Differentiation in Malignant Phyllodes Tumor is Histologically Similar but Immunohistochemically and Molecularly Distinct from Well-differentiated Liposarcoma of Soft Tissue. ( 26843318 )
2016
34
Giant Cervico-mediastinal Well-differentiated Liposarcoma. ( 25837020 )
2015
35
Intramuscular atypical lipomatous tumor/well-differentiated liposarcoma of the pectoralis major masquerading as a breast tumor: management and review of the literature. ( 25692417 )
2015
36
Primary well-differentiated liposarcoma of the eyelid clinically masquerading as a benign tumour: a rare entity confirmed by murine double minute 2 fluorescence in-situ hybridization. ( 25753497 )
2015
37
Vulvar Myxoid Liposarcoma and Well Differentiated Liposarcoma With Molecular Cytogenetic Confirmation: Case Reports With Review of Malignant Lipomatous Tumors of the Vulva. ( 25851712 )
2015
38
Multiple mesenteric well-differentiated liposarcoma complicated by purulent inflammation: A case report. ( 25663908 )
2015
39
Well-differentiated liposarcoma arising in the parapharyngeal space: a case report and review of the literature. ( 25706170 )
2015
40
Multiple spinal metastases from a well-differentiated liposarcoma of the iliac wing: a case report. ( 28053711 )
2015
41
Atypical lipomatous tumor/well-differentiated liposarcoma of the gingiva: a case report and review of literature. ( 23992781 )
2014
42
Well differentiated liposarcoma of spermatic cord: report of 3 rare cases. ( 25250255 )
2014
43
CDK4 amplification predicts recurrence of well-differentiated liposarcoma of the abdomen. ( 25121597 )
2014
44
D-dimer levels in the differential diagnosis between lipoma and well-differentiated liposarcoma. ( 25202112 )
2014
45
FDG PET/CT findings in a rare case of giant fibrovascular polyp of the esophagus harboring atypical lipomatous tumor/well-differentiated liposarcoma. ( 24458178 )
2014
46
Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements. ( 24505276 )
2014
47
Estrogen receptor alpha and androgen receptor are commonly expressed in well-differentiated liposarcoma. ( 25349530 )
2014
48
Well-differentiated liposarcoma of the epiglottis. ( 24521797 )
2014
49
Massive, well-differentiated liposarcoma of the axilla. ( 27141245 )
2014
50
Giant atypical lipoma of the thigh. ( 24354663 )
2014

Variations for Well-Differentiated Liposarcoma

Expression for Well-Differentiated Liposarcoma

Search GEO for disease gene expression data for Well-Differentiated Liposarcoma.

Pathways for Well-Differentiated Liposarcoma

Pathways related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.88 CDK4 CDKN2A MDM2
2 11.75 CDK4 CDKN2A MDM2
3 11.38 CDK4 CDKN2A MDM2
4 11 CDK4 CDKN2A MDM2
5 10.66 CDKN2A MDM2
6
Show member pathways
10.6 CDKN2A MDM2
7 10.3 CDK4 CDKN2A MDM2

GO Terms for Well-Differentiated Liposarcoma

Cellular components related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 CDKN2A HMGA2

Biological processes related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.73 CDK4 DDR2 MDM2 TSPAN31
2 ventricular septum development GO:0003281 9.4 FRS2 MDM2
3 negative regulation of cell cycle arrest GO:0071157 9.37 CDK4 MDM2
4 positive regulation of cellular senescence GO:2000774 9.32 CDKN2A HMGA2
5 chondrocyte proliferation GO:0035988 9.26 DDR2 HMGA2
6 amyloid fibril formation GO:1990000 9.16 CDKN2A MDM2
7 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 8.96 CDK4 CDKN2A
8 senescence-associated heterochromatin focus assembly GO:0035986 8.62 CDKN2A HMGA2

Molecular functions related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SUMO transferase activity GO:0019789 8.62 CDKN2A MDM2

Sources for Well-Differentiated Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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