MCID: WLL039
MIFTS: 38

Well-Differentiated Liposarcoma

Categories: Rare diseases

Aliases & Classifications for Well-Differentiated Liposarcoma

MalaCards integrated aliases for Well-Differentiated Liposarcoma:

Name: Well-Differentiated Liposarcoma 60 17
Atypical Lipoma 60 74
Liposarcoma, Well Differentiated 74
Atypical Lipomatous Tumor 60
Pleomorphic Lipoma 74
Wdls 60
Alt 60

Characteristics:

Orphanet epidemiological data:

60
well-differentiated liposarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

ICD10 via Orphanet 35 C49.9
UMLS via Orphanet 75 C1370889
Orphanet 60 ORPHA99971
SNOMED-CT via HPO 70 39539005 95325000

Summaries for Well-Differentiated Liposarcoma

MalaCards based summary : Well-Differentiated Liposarcoma, also known as atypical lipoma, is related to pleomorphic lipoma and lipomatosis, multiple. An important gene associated with Well-Differentiated Liposarcoma is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are Viral carcinogenesis and Cellular senescence (KEGG). Affiliated tissues include tongue, skin and testes, and related phenotypes are subcutaneous nodule and abnormal renal physiology

Related Diseases for Well-Differentiated Liposarcoma

Diseases related to Well-Differentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 31.7 HMGA2 MDM2
2 lipomatosis, multiple 31.5 CDK4 HMGA2 MDM2
3 liposarcoma 31.3 CDK4 CDKN2A HMGA2 MDM2 TSPAN31
4 atypical lipomatous tumor 30.7 CDK4 CDKN2A HMGA2 MDM2 TSPAN31
5 dedifferentiated liposarcoma 30.7 CDK4 CDKN2A HMGA2 MDM2
6 myxoid liposarcoma 30.7 CDK4 HMGA2 MDM2
7 lipoblastoma 30.7 CDK4 MDM2
8 infiltrating lipoma 30.6 CDK4 HMGA2 MDM2
9 spindle cell lipoma 30.6 CDK4 MDM2
10 cellular myxoid liposarcoma 30.6 CDK4 MDM2
11 spindle cell liposarcoma 30.4 CDK4 MDM2
12 spindle cell sarcoma 30.3 KRT7 MDM2 MUC1
13 pleomorphic liposarcoma 30.1 CDKN2A MDM2 MUC1
14 ring chromosome 7 10.4 CDK4 MDM2
15 mesenchymoma 10.4 HMGA2 MDM2
16 undifferentiated embryonal sarcoma of the liver 10.4 CDK4 MDM2
17 embryonal sarcoma 10.4 CDK4 MDM2
18 malignant fibrous histiocytoma of bone 10.4 CDK4 MDM2
19 bone osteosarcoma 10.4 CDK4 MDM2
20 cornea cancer 10.4 CDK4 CDKN2A
21 scrotal carcinoma 10.4 CDKN2A HMGA2
22 conventional leiomyosarcoma 10.4 CDKN2A HMGA2
23 mixed liposarcoma 10.4 CDK4 MDM2
24 cervical adenoma malignum 10.4 HMGA2 KRT7
25 periosteal osteogenic sarcoma 10.4 CDK4 MDM2
26 cervical mucinous adenocarcinoma 10.4 HMGA2 KRT7
27 inverted transitional papilloma 10.3 CDKN2A KRT7
28 small cell sarcoma 10.3 CDK4 MDM2
29 vulval paget's disease 10.3 CDKN2A KRT7
30 adenoid basal cell carcinoma 10.3 CDKN2A KRT7
31 ewing's family of tumors 10.3 CDK4 CDKN2A
32 endocervical carcinoma 10.3 CDKN2A KRT7
33 bladder carcinoma in situ 10.3 CDKN2A KRT7
34 nasal cavity cancer 10.3 CDKN2A KRT7
35 vulvar disease 10.3 CDKN2A KRT7
36 nasal cavity adenocarcinoma 10.3 CDKN2A KRT7
37 vulva adenocarcinoma 10.3 CDKN2A KRT7
38 anal canal carcinoma 10.3 CDKN2A KRT7
39 glycogen-rich clear cell breast carcinoma 10.3 CDKN2A KRT7
40 thymus lipoma 10.3 HMGA2 KRT7
41 malignant peritoneal mesothelioma 10.3 CDKN2A MUC1
42 peritoneal mesothelioma 10.3 CDKN2A MUC1
43 verrucous carcinoma 10.3 CDKN2A MDM2
44 epithelial-myoepithelial carcinoma 10.3 HMGA2 KRT7
45 endocervical adenocarcinoma 10.3 CDKN2A KRT7
46 breast secretory carcinoma 10.3 CDK4 KRT7
47 immune system organ benign neoplasm 10.3 HMGA2 KRT7
48 endometrial mucinous adenocarcinoma 10.3 CDKN2A MUC1
49 cholangiolocellular carcinoma 10.3 CDKN2A MUC1
50 anaplastic ependymoma 10.3 MDM2 MUC1

Graphical network of the top 20 diseases related to Well-Differentiated Liposarcoma:



Diseases related to Well-Differentiated Liposarcoma

Symptoms & Phenotypes for Well-Differentiated Liposarcoma

Human phenotypes related to Well-Differentiated Liposarcoma:

60 33
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 60 33 hallmark (90%) Very frequent (99-80%) HP:0001482
2 abnormal renal physiology 60 33 occasional (7.5%) Occasional (29-5%) HP:0012211
3 gastrointestinal dysmotility 60 33 occasional (7.5%) Occasional (29-5%) HP:0002579

MGI Mouse Phenotypes related to Well-Differentiated Liposarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 CAVIN2 CDK4 CDKN2A DDR2 FRS2 MDM2

Drugs & Therapeutics for Well-Differentiated Liposarcoma

Search Clinical Trials , NIH Clinical Center for Well-Differentiated Liposarcoma

Genetic Tests for Well-Differentiated Liposarcoma

Anatomical Context for Well-Differentiated Liposarcoma

MalaCards organs/tissues related to Well-Differentiated Liposarcoma:

42
Tongue, Skin, Testes, Pancreas, Thyroid, Adrenal Gland, Thymus

Publications for Well-Differentiated Liposarcoma

Articles related to Well-Differentiated Liposarcoma:

(show top 50) (show all 157)
# Title Authors Year
1
Orbital Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Masquerading as Pleomorphic Lipoma: A Diagnostic Challenge. ( 30908464 )
2019
2
Well-differentiated liposarcoma and dedifferentiated liposarcoma: An updated review. ( 30852045 )
2019
3
A novel sclerosing atypical lipomatous tumor/well-differentiated liposarcoma in a 7-year-old girl: report of a case with molecular confirmation. ( 28705709 )
2018
4
Primary atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) of the breast. ( 28845581 )
2018
5
Well-Differentiated Liposarcoma (Atypical Lipomatous Tumor) Presenting as an Esophageal Polyp. ( 29349606 )
2018
6
Primary Breast Atypical Lipomatous Tumor/ Well-Differentiated Liposarcoma and Dedifferentiated Liposarcoma. ( 29372852 )
2018
7
Corrigendum to "Pericytic mimicry in well-differentiated liposarcoma/atypical lipomatous tumor" (Hum Pathol 2016;54:92-99). ( 29958690 )
2018
8
Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin. ( 29610390 )
2018
9
Spinal Metastasis of Well-Differentiated Liposarcoma Component in Retroperitoneal Dedifferentiated Liposarcoma Treated by Minimally Invasive Surgery. ( 30123596 )
2018
10
The clinical behavior of well differentiated liposarcoma can be extremely variable: A retrospective cohort study at a major sarcoma center. ( 29723411 )
2018
11
Fatty tumors of the retroperitoneum: Lipoma or well-differentiated liposarcoma. About a case of a giant retroperitoneal liposarcoma. ( 30211007 )
2018
12
A Well-Differentiated Liposarcoma in the Digit: A Case Report of the 5-Year Post-Surgical Follow-Up. ( 30282536 )
2018
13
Well-differentiated liposarcoma of the breast arising in a background of malignant phyllodes tumor in a pregnant woman: A rare case report and review of literature. ( 30303154 )
2018
14
Well-Differentiated Liposarcoma Localized to the Thyroid Gland. ( 30374430 )
2018
15
ASO Author Reflections: Recurrent Retroperitoneal Well-Differentiated Liposarcoma. ( 30556116 )
2018
16
Concomitant organ resection does not improve outcomes in primary retroperitoneal well-differentiated liposarcoma: A retrospective cohort study at a major sarcoma center. ( 29228466 )
2018
17
Surgery for Abdominal Well-Differentiated Liposarcoma. ( 29335908 )
2018
18
Amplification of FRS2 in atypical lipomatous tumour/well-differentiated liposarcoma and de-differentiated liposarcoma: a clinicopathological and genetic study of 146 cases. ( 29368794 )
2018
19
Salvage Surgery for Recurrent Retroperitoneal Well-Differentiated Liposarcoma: Early Reoperation may not Provide Benefit. ( 29520652 )
2018
20
Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry. ( 27597521 )
2017
21
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Developed in a Patient with Progressive Muscular Dystrophy: A Case Report and Review of the Literature. ( 28634560 )
2017
22
Endoscopic submucosal dissection of a huge esophageal atypical lipomatous tumor (well-differentiated liposarcoma) with a 4-year recurrence-free survival. ( 28719927 )
2017
23
Paravertebral Well-Differentiated Liposarcoma with Low-Grade Osteosarcomatous Component: Case Report with 11-Year Follow-Up, Radiological, Pathological, and Genetic Data, and Literature Review. ( 28377828 )
2017
24
Well-differentiated Liposarcoma in a Bonnet Macaque (Macaca radiata). ( 28381318 )
2017
25
Well-differentiated liposarcoma with chondroid metaplasia in the auricle of a dog. ( 28603215 )
2017
26
Pedunculated, well differentiated liposarcoma of the oesophagus mimicking giant fibrovascular polyp. ( 28853590 )
2017
27
Cavin-2 is a specific marker for detection of well-differentiated liposarcoma. ( 28865960 )
2017
28
Giant atypical lipoma. ( 28954109 )
2017
29
Pericytic mimicry in well-differentiated liposarcoma/atypical lipomatous tumor. ( 27063472 )
2016
30
Challenging differential diagnosis between lipoma and well-differentiated liposarcoma in the retroperitoneum. A case report. ( 27212576 )
2016
31
Well-Differentiated Liposarcoma With Hibernoma-Like Morphology. ( 27272683 )
2016
32
Can Abdominal Computed Tomography Imaging Help Accurately Identify a Dedifferentiated Component in a Well-Differentiated Liposarcoma? ( 27454788 )
2016
33
Well-differentiated liposarcoma of the floor of the mouth: Report of a rare case and review of the literature. ( 27601829 )
2016
34
Well differentiated liposarcoma, sclerosing type, of the pancreas a case report. ( 27840110 )
2016
35
Heterologous Liposarcomatous Differentiation in Malignant Phyllodes Tumor is Histologically Similar but Immunohistochemically and Molecularly Distinct from Well-differentiated Liposarcoma of Soft Tissue. ( 26843318 )
2016
36
Intramuscular atypical lipomatous tumor/well-differentiated liposarcoma of the pectoralis major masquerading as a breast tumor: management and review of the literature. ( 25692417 )
2015
37
Multiple mesenteric well-differentiated liposarcoma complicated by purulent inflammation: A case report. ( 25663908 )
2015
38
Well-differentiated liposarcoma arising in the parapharyngeal space: a case report and review of the literature. ( 25706170 )
2015
39
Primary well-differentiated liposarcoma of the eyelid clinically masquerading as a benign tumour: a rare entity confirmed by murine double minute 2 fluorescence in-situ hybridization. ( 25753497 )
2015
40
Giant Cervico-mediastinal Well-differentiated Liposarcoma. ( 25837020 )
2015
41
Vulvar Myxoid Liposarcoma and Well Differentiated Liposarcoma With Molecular Cytogenetic Confirmation: Case Reports With Review of Malignant Lipomatous Tumors of the Vulva. ( 25851712 )
2015
42
Multiple spinal metastases from a well-differentiated liposarcoma of the iliac wing: a case report. ( 28053711 )
2015
43
Atypical lipomatous tumor/well-differentiated liposarcoma of the gingiva: a case report and review of literature. ( 23992781 )
2014
44
FDG PET/CT findings in a rare case of giant fibrovascular polyp of the esophagus harboring atypical lipomatous tumor/well-differentiated liposarcoma. ( 24458178 )
2014
45
Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements. ( 24505276 )
2014
46
Well-differentiated liposarcoma of the epiglottis. ( 24521797 )
2014
47
CDK4 amplification predicts recurrence of well-differentiated liposarcoma of the abdomen. ( 25121597 )
2014
48
D-dimer levels in the differential diagnosis between lipoma and well-differentiated liposarcoma. ( 25202112 )
2014
49
Well differentiated liposarcoma of spermatic cord: report of 3 rare cases. ( 25250255 )
2014
50
Estrogen receptor alpha and androgen receptor are commonly expressed in well-differentiated liposarcoma. ( 25349530 )
2014

Variations for Well-Differentiated Liposarcoma

Expression for Well-Differentiated Liposarcoma

Search GEO for disease gene expression data for Well-Differentiated Liposarcoma.

Pathways for Well-Differentiated Liposarcoma

Pathways related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.88 CDK4 CDKN2A MDM2
2 11.75 CDK4 CDKN2A MDM2
3 11.38 CDK4 CDKN2A MDM2
4 11 CDK4 CDKN2A MDM2
5 10.66 CDKN2A MDM2
6
Show member pathways
10.6 CDKN2A MDM2
7 10.3 CDK4 CDKN2A MDM2

GO Terms for Well-Differentiated Liposarcoma

Cellular components related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 CDKN2A HMGA2

Biological processes related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 CDK4 DDR2 MDM2 TSPAN31
2 ventricular septum development GO:0003281 9.37 FRS2 MDM2
3 negative regulation of cell cycle arrest GO:0071157 9.32 CDK4 MDM2
4 positive regulation of cellular senescence GO:2000774 9.26 CDKN2A HMGA2
5 chondrocyte proliferation GO:0035988 9.16 DDR2 HMGA2
6 amyloid fibril formation GO:1990000 8.96 CDKN2A MDM2
7 senescence-associated heterochromatin focus assembly GO:0035986 8.62 CDKN2A HMGA2

Molecular functions related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SUMO transferase activity GO:0019789 8.62 CDKN2A MDM2

Sources for Well-Differentiated Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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