ALT
MCID: WLL039
MIFTS: 40

Well-Differentiated Liposarcoma (ALT)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Well-Differentiated Liposarcoma

MalaCards integrated aliases for Well-Differentiated Liposarcoma:

Name: Well-Differentiated Liposarcoma 12 58 15 17
Atypical Lipomatous Tumor 12 58 17
Atypical Lipoma 58 71
Liposarcoma, Well Differentiated 71
Pleomorphic Lipoma 71
Wdls 58
Alt 58

Characteristics:

Orphanet epidemiological data:

58
well-differentiated liposarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:5690
MeSH 44 D008080
NCIt 50 C4250
SNOMED-CT 67 28655007
ICD10 via Orphanet 33 C49.9
UMLS via Orphanet 72 C1370889
Orphanet 58 ORPHA99971
SNOMED-CT via HPO 68 39539005 95325000
UMLS 71 C0205823 C1266129 C1370889

Summaries for Well-Differentiated Liposarcoma

Disease Ontology : 12 A liposarcoma that is characterized as a slow growing, painless tumor usually located in the retroperitoneum or the limbs and derives from proliferating mature adipocytes.

MalaCards based summary : Well-Differentiated Liposarcoma, also known as atypical lipomatous tumor, is related to pleomorphic lipoma and liposarcoma. An important gene associated with Well-Differentiated Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Bladder cancer. The drugs Palbociclib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include tongue, skin and smooth muscle, and related phenotypes are subcutaneous nodule and gastrointestinal dysmotility

Related Diseases for Well-Differentiated Liposarcoma

Diseases related to Well-Differentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 270)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 31.7 TSPAN31 SERPINA3 MDM2 HMGA2 CDK4 CD34
2 liposarcoma 31.4 TSPAN31 MDM2 HMGA2 FUS FRS2 EWSR1
3 lipomatosis, multiple 31.2 TSPAN31 SERPINA3 MDM2 HMGA2 FUS EWSR1
4 lipoblastoma 31.1 MDM2 CDK4
5 inflammatory liposarcoma 31.1 MDM2 CDKN2A CD34
6 infiltrating lipoma 31.1 MDM2 HMGA2 CDK4 CD34
7 spindle cell lipoma 31.0 MDM2 CDK4 CD34
8 juxtacortical osteosarcoma 30.9 MDM2 FRS2 CDK4
9 fibrous histiocytoma 30.9 SERPINA3 FUS EWSR1 CD34
10 spindle cell liposarcoma 30.9 MDM2 DDIT3 CDK4 CD34
11 sclerosing liposarcoma 30.8 MDM2 FUS CD34
12 spindle cell sarcoma 30.8 SERPINA3 MUC1 MDM2 KRT7 EWSR1 CD34
13 angiolipoma 30.8 MDM2 CD34
14 malignant fibrous histiocytoma 30.8 SERPINA3 MUC1 MDM2 EWSR1 DDIT3 CDK4
15 mediastinum liposarcoma 30.7 MDM2 CDKN2A CDK4
16 myxoid liposarcoma 30.7 MDM2 HMGA2 FUS EWSR1 DDIT3 CDK4
17 embryonal sarcoma 30.7 SERPINA3 MDM2 CDK4
18 fibroma 30.7 SERPINA3 KRT7 CD34
19 mesenchymal cell neoplasm 30.7 SERPINA3 HMGA2 EWSR1 CD34
20 familial retinoblastoma 30.6 TSPAN31 MDM2 CDKN2A CDK4
21 sarcoma 30.6 MUC1 MDM2 FUS EWSR1 DDIT3 CDK4
22 glomus tumor 30.6 MUC1 CDKN2A CD34
23 neurofibroma 30.5 MUC1 CDKN2A CD34
24 inflammatory myofibroblastic tumor 30.5 MUC1 MDM2 CDK4 CD34
25 pleomorphic liposarcoma 30.5 SERPINA3 MUC1 MDM2 FUS EWSR1 DDIT3
26 angiosarcoma 30.5 MUC1 KRT7 CD34
27 ring chromosome 30.5 MDM2 HMGA2 EWSR1 CDK4
28 mixed liposarcoma 30.4 MDM2 FUS DDIT3 CDK4 CD34
29 chondrosarcoma 30.4 SERPINA3 MUC1 MDM2 EWSR1 CDK4
30 leiomyosarcoma 30.4 SERPINA3 MUC1 MDM2 HMGA2 CDKN2A CDK4
31 dedifferentiated liposarcoma 30.3 TSPAN31 SERPINA3 MUC1 MIR100 MDM2 HMGA2
32 myxofibrosarcoma 30.3 SERPINA3 MUC1 MDM2 FUS EWSR1 DDIT3
33 connective tissue benign neoplasm 30.3 SERPINA3 MDM2 EWSR1 CDK4 CD34
34 cellular myxoid liposarcoma 30.2 SERPINA3 MDM2 FUS EWSR1 DDIT3 CDK4
35 rhabdomyosarcoma 30.2 MDM2 KRT7 HMGA2 FUS EWSR1 CDKN2A
36 endobronchial lipoma 30.1 KRT7 EWSR1
37 ring chromosome 7 10.5 MDM2 CDK4
38 cervical basaloid squamous cell carcinoma 10.5 KRT7 CDKN2A
39 esophagus verrucous carcinoma 10.5 MDM2 CDKN2A
40 diffuse lipomatosis 10.5 MDM2 CDK4
41 inverted transitional papilloma 10.5 KRT7 CDKN2A
42 anal canal paget's disease 10.5 KRT7 CDKN2A
43 cervical mucinous adenocarcinoma 10.5 KRT7 HMGA2
44 paratesticular lipoma 10.5 MDM2 CDK4
45 lipoma of spermatic cord 10.5 MDM2 CDK4
46 cervical adenoid cystic carcinoma 10.5 KRT7 CDKN2A
47 aortic malignant tumor 10.5 MDM2 CD34
48 atrophic vulva 10.5 KRT7 CDKN2A
49 malignant peritoneal mesothelioma 10.5 MUC1 CDKN2A
50 scrotum paget's disease 10.5 MUC1 KRT7

Graphical network of the top 20 diseases related to Well-Differentiated Liposarcoma:



Diseases related to Well-Differentiated Liposarcoma

Symptoms & Phenotypes for Well-Differentiated Liposarcoma

Human phenotypes related to Well-Differentiated Liposarcoma:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482
2 gastrointestinal dysmotility 58 31 occasional (7.5%) Occasional (29-5%) HP:0002579
3 abnormal renal physiology 58 31 occasional (7.5%) Occasional (29-5%) HP:0012211

Drugs & Therapeutics for Well-Differentiated Liposarcoma

Drugs for Well-Differentiated Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
2 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of CDK4/6 Inhibition (Palbociclib) Combined With PD-1 Blockade (INCMGA00012) in Patients With Advanced Well-differentiated and/or Dedifferentiated Liposarcoma Recruiting NCT04438824 Phase 2 INCMGA00012;Palbociclib

Search NIH Clinical Center for Well-Differentiated Liposarcoma

Genetic Tests for Well-Differentiated Liposarcoma

Anatomical Context for Well-Differentiated Liposarcoma

MalaCards organs/tissues related to Well-Differentiated Liposarcoma:

40
Tongue, Skin, Smooth Muscle, Colon, Adipocyte, Pancreas, Thyroid

Publications for Well-Differentiated Liposarcoma

Articles related to Well-Differentiated Liposarcoma:

(show top 50) (show all 918)
# Title Authors PMID Year
1
The recurrence of well-differentiated liposarcoma from benign giant intramuscular lipoma: A case (CARE-compliant) report. 61
33578611 2021
2
The Utility of Perilipin in Liposarcomas: PLIN1 Differentiates Round Cell Liposarcoma From Other Round Cell Sarcomas. 61
32205741 2021
3
Establishment and characterization of a novel cell line, NCC-DDLPS2-C1, derived from a patient with dedifferentiated liposarcoma. 61
33555519 2021
4
Preoperative Biopsy in Patients with Retroperitoneal Sarcoma: Usage and Outcomes in a National Cohort. 61
33591480 2021
5
Prognostic significance of the MDM2/HMGA2 ratio and histological tumor grade in dedifferentiated liposarcoma. 61
33111425 2021
6
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on 18F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma. 61
33505228 2021
7
Parosteal osteosarcoma associated with a low-grade component mimicking well-differentiated liposarcoma: a case report. 61
32564106 2021
8
Recent developments in gastroesophageal mesenchymal tumours. 61
33382494 2021
9
Clinical features of multiply recurrent retroperitoneal liposarcoma: A single-center experience. 61
33191070 2021
10
Recent Advancement in Atypical Lipomatous Tumor Research. 61
33498189 2021
11
Surgical management of a large retroperitoneal liposarcoma: A case study. 61
33318934 2021
12
Resection of a giant retroperitoneal lipoma herniating through the inguinal canal. 61
33500309 2021
13
Evaluating the Impact of Surveillance Follow-Up Intervals in Patients Following Resection of Primary Well-Differentiated Liposarcoma of the Retroperitoneum. 61
32409969 2021
14
The MDM2 inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma. 61
33410915 2021
15
Resection of a giant mediastinal atypical lipomatous tumor involving the esophagus. 61
33505654 2021
16
[A Case of Lipoma Arising from the Mesentery Proper That Had Difficulty in Differential Diagnosis with Well-Differentiated Liposarcoma]. 61
33468834 2020
17
ASO Author Reflections: Surveillance After Resection of Retroperitoneal Well-Differentiated Liposarcoma: A Balancing Act Between Earlier Recurrence Detection, Patient Anxiety, and Health Care Resource Expenditure. 61
32409970 2020
18
A Rapid and Cost-Effective Gene Expression Assay for the Diagnosis of Well-Differentiated and Dedifferentiated Liposarcomas. 61
33346147 2020
19
Synchronous Renal Dedifferentiated Liposarcoma and Retroperitoneal Well-Differentiated Liposarcoma: A Case Report With Literature Review. 61
33355009 2020
20
A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study. 61
32701199 2020
21
What Are the Results of Resection of Localized Dedifferentiated Liposarcomas in the Extremities? 61
33112583 2020
22
Pilot study to differentiate lipoma from atypical lipomatous tumour/well-differentiated liposarcoma using MR radiomics-based texture analysis. 61
32424704 2020
23
A rare case of liposarcoma of the spermatic cord. 61
33102038 2020
24
Rare MDM2 amplification in a fat-predominant angiomyolipoma. 61
32409886 2020
25
Giant retroperitoneal liposarcoma with a maximum diameter of 37 cm: a case report and review of literature. 61
33178780 2020
26
Inflammatory Variant of Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Buccal Mucosa: An Overview and Case Report with a 10-Year Follow-Up. 61
33091145 2020
27
Discrimination of well-differentiated liposarcoma from benign lipoma on sonography: an uncontrolled retrospective study. 61
32960385 2020
28
Well-differentiated liposarcoma primary from thymic stroma: Case report and literature review. 61
32791064 2020
29
Dedifferentiated Liposarcoma With Meningothelial-Like Whorls: Five Additional Cases and Review of the Literature. 61
32419561 2020
30
Dedifferentiated liposarcoma with heterologous spindle cell rhabdomyoblastic de-differentiation: An unusual pattern expanding the morphological spectrum. 61
33154322 2020
31
Recurrent retroperitoneal sarcomas: Clinical outcomes of surgical treatment and prognostic factors. 61
32950313 2020
32
[Video-assisted Thoracic Surgery of an Hourglass Transmural Lipoma;Report of a Case]. 61
32879280 2020
33
Primary Sarcomas of the Larynx: A Single Institutional Experience with Ten Cases. 61
31813100 2020
34
Atypical Spindle Cell Lipomatous Lesion Resected From Patient With History of CLL. 61
32683914 2020
35
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Orbit: Three Cases and Review of the Literature. 61
32991496 2020
36
Nuclear expression of MDM2 in hibernoma: a potential diagnostic pitfall. 61
32815035 2020
37
A Rare Case of Vulvar Hibernoma Treated With Resection. 61
32789056 2020
38
An extremely rare case of rapidly growing mediastinal well-differentiated liposarcoma with a sclerosing variant: a case report. 61
32621145 2020
39
Dysplastic lipoma: potential diagnostic pitfall of using MDM2 RNA in situ hybridization to distinguish between lipoma and atypical lipomatous tumor. 61
32439322 2020
40
Fibro-adipose vascular anomaly (FAVA): three case reports with an emphasis on the mammalian target of rapamycin (mTOR) pathway. 61
32711543 2020
41
Expanding the differential of cutaneous epithelioid tumors: A case of dedifferentiated liposarcoma with epithelioid features involving the skin, with review of the literature. 61
31995237 2020
42
Molecular Characterization of a Rare Dedifferentiated Liposarcoma With Rhabdomyosarcomatous Differentiation in a 24 Year Old. 61
31801397 2020
43
Qualitative evaluation of MRI features of lipoma and atypical lipomatous tumor: results from a multicenter study. 61
31965239 2020
44
An MRI-based decision tree to distinguish lipomas and lipoma variants from well-differentiated liposarcoma of the extremity and superficial trunk: Classification and regression tree (CART) analysis. 61
32339981 2020
45
Quantitative signal intensity ratios to distinguish between subfascial lipoma and atypical lipomatous tumor/well-differentiated liposarcoma using short-tau inversion recovery (STIR) MRI. 61
32107197 2020
46
En Bloc Resection of a Giant Retroperitoneal Liposarcoma: A Surgical Challenge. 61
32714670 2020
47
Primary Well-Differentiated Liposarcoma of the Orbit. 61
32450731 2020
48
Surgical management of truncal and extremities atypical lipomatous tumors/well-differentiated liposarcoma: A systematic review of the literature. 61
32029218 2020
49
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma With Features Mimicking Spindle Cell Lipoma. 61
31672072 2020
50
Low-grade Osteosarcomatous Dedifferentiation of an Atypical Lipomatous Tumor in a Pediatric Patient. 61
31739757 2020

Variations for Well-Differentiated Liposarcoma

Expression for Well-Differentiated Liposarcoma

Search GEO for disease gene expression data for Well-Differentiated Liposarcoma.

Pathways for Well-Differentiated Liposarcoma

Pathways related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.3 MDM2 HMGA2 FUS EWSR1 DDIT3
2 11.2 MDM2 CDKN2A CDK4
3 10.64 MDM2 CDKN2A CDK4

GO Terms for Well-Differentiated Liposarcoma

Cellular components related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.8 SYT1 PPIAL4F PPIAL4A MUC1 MDM2 KRT7
2 senescence-associated heterochromatin focus GO:0035985 8.62 HMGA2 CDKN2A

Biological processes related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chondrocyte proliferation GO:0035988 9.26 HMGA2 DDR2
2 amyloid fibril formation GO:1990000 9.16 MDM2 CDKN2A
3 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043618 8.96 MUC1 DDIT3
4 senescence-associated heterochromatin focus assembly GO:0035986 8.62 HMGA2 CDKN2A

Molecular functions related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 9.13 MUC1 MDM2 CDKN2A
2 transcription coregulator activity GO:0003712 8.92 MUC1 HMGA2 FUS EWSR1

Sources for Well-Differentiated Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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