ALT
MCID: WLL039
MIFTS: 40

Well-Differentiated Liposarcoma (ALT)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Well-Differentiated Liposarcoma

MalaCards integrated aliases for Well-Differentiated Liposarcoma:

Name: Well-Differentiated Liposarcoma 12 58 17
Atypical Lipomatous Tumor 12 58 15 17
Atypical Lipoma 58 71
Liposarcoma, Well Differentiated 71
Pleomorphic Lipoma 71
Wdls 58
Alt 58

Characteristics:

Orphanet epidemiological data:

58
well-differentiated liposarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:5690
NCIt 49 C4250
SNOMED-CT 67 28655007
ICD10 via Orphanet 33 C49.9
UMLS via Orphanet 72 C1370889
Orphanet 58 ORPHA99971
SNOMED-CT via HPO 68 39539005 95325000
UMLS 71 C0205823 C1266129 C1370889

Summaries for Well-Differentiated Liposarcoma

Disease Ontology : 12 A liposarcoma that is characterized as a slow growing, painless tumor usually located in the retroperitoneum or the limbs and derives from proliferating mature adipocytes.

MalaCards based summary : Well-Differentiated Liposarcoma, also known as atypical lipomatous tumor, is related to pleomorphic lipoma and soft tissue sarcoma. An important gene associated with Well-Differentiated Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are Chromatin Regulation / Acetylation and Transcriptional misregulation in cancer. Affiliated tissues include adipocyte, breast and bone, and related phenotypes are subcutaneous nodule and abnormal renal physiology

Related Diseases for Well-Differentiated Liposarcoma

Diseases related to Well-Differentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 263)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 31.6 TSPAN31 MDM2 HMGA2 CDK4 CD34
2 soft tissue sarcoma 31.3 MDM2 EWSR1
3 dedifferentiated liposarcoma 31.3 MDM2 HMGA2 DDIT3 CDKN2A CDK4
4 lipoblastoma 31.2 MDM2 CDK4
5 infiltrating lipoma 31.2 MDM2 HMGA2 CDK4
6 inflammatory liposarcoma 31.1 MDM2 CDKN2A CD34
7 angiolipoma 31.1 MDM2 CD34
8 spindle cell lipoma 31.0 MDM2 CD34
9 embryonal sarcoma 30.9 MDM2 CDK4
10 fibrous histiocytoma 30.9 FUS EWSR1 CD34
11 juxtacortical osteosarcoma 30.8 MDM2 CDK4
12 mediastinum liposarcoma 30.8 MDM2 CDKN2A CDK4
13 sclerosing liposarcoma 30.8 MDM2 FUS CD34
14 familial retinoblastoma 30.7 MDM2 CDKN2A CDK4
15 spindle cell liposarcoma 30.7 MDM2 DDIT3 CDK4 CD34
16 ring chromosome 30.7 MDM2 HMGA2 EWSR1 CDK4
17 lipomatosis, multiple 30.7 TSPAN31 MDM2 HMGA2 FUS EWSR1 DDIT3
18 liposarcoma 30.6 TSPAN31 MDM2 HMGA2 FUS FRS2 EWSR1
19 glomus tumor 30.6 MUC1 CDKN2A CD34
20 malignant mesenchymoma 30.5 MDM2 CD34
21 connective tissue benign neoplasm 30.5 MDM2 CDK4 CD34
22 malignant fibroxanthoma 30.5 MUC1 MDM2 HMGA2 DDIT3 CDK4 CD34
23 spindle cell sarcoma 30.5 SS18 MUC1 MDM2 KRT7 CD34
24 inflammatory myofibroblastic tumor 30.4 MUC1 MDM2 CDK4 CD34
25 mesenchymal cell neoplasm 30.4 SS18 HMGA2 EWSR1 CD34
26 chondrosarcoma 30.4 MUC1 MDM2 EWSR1 CDK4
27 histiocytoma 30.4 MDM2 FUS EWSR1 CDKN2A CDK4 CD34
28 angiosarcoma 30.3 MUC1 MDM2 KRT7 CD34
29 leiomyosarcoma 30.3 MUC1 MDM2 HMGA2 CDKN2A CDK4
30 mixed liposarcoma 30.1 MDM2 FUS DDIT3 CDK4 CD34
31 myxoid liposarcoma 30.1 SS18 MDM2 HMGA2 FUS EWSR1 DDIT3
32 cellular myxoid liposarcoma 29.9 SS18 MDM2 FUS EWSR1 DDIT3 CDK4
33 pleomorphic liposarcoma 29.6 SS18 MUC1 MDM2 FUS EWSR1 DDIT3
34 endobronchial lipoma 29.4 KRT7 EWSR1
35 sarcoma 29.4 TSPAN31 SS18 MUC1 MDM2 FUS EWSR1
36 ring chromosome 7 10.6 MDM2 CDK4
37 diffuse lipomatosis 10.6 MDM2 CDK4
38 undifferentiated embryonal sarcoma of the liver 10.6 MDM2 CDK4
39 esophagus verrucous carcinoma 10.6 MDM2 CDKN2A
40 cervical basaloid squamous cell carcinoma 10.6 KRT7 CDKN2A
41 inverted transitional papilloma 10.6 KRT7 CDKN2A
42 endometrial transitional cell carcinoma 10.6 KRT7 CDKN2A
43 anal canal paget's disease 10.6 KRT7 CDKN2A
44 adult liposarcoma 10.6 MDM2 CDK4
45 anus basaloid carcinoma 10.6 KRT7 CDKN2A
46 cervical adenoid cystic carcinoma 10.6 KRT7 CDKN2A
47 atrophic vulva 10.6 KRT7 CDKN2A
48 malignant peritoneal mesothelioma 10.6 MUC1 CDKN2A
49 vulvar eccrine porocarcinoma 10.6 MUC1 CDKN2A
50 ovarian seromucinous carcinoma 10.6 KRT7 CDKN2A

Graphical network of the top 20 diseases related to Well-Differentiated Liposarcoma:



Diseases related to Well-Differentiated Liposarcoma

Symptoms & Phenotypes for Well-Differentiated Liposarcoma

Human phenotypes related to Well-Differentiated Liposarcoma:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482
2 abnormal renal physiology 58 31 occasional (7.5%) Occasional (29-5%) HP:0012211
3 gastrointestinal dysmotility 58 31 occasional (7.5%) Occasional (29-5%) HP:0002579

Drugs & Therapeutics for Well-Differentiated Liposarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Single Arm Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well-Differentiated or Dedifferentiated Liposarcoma Unknown status NCT02571829 Phase 2 ribociclib
2 Phase II Clinical Trial of Pazopanib to Evaluate the Activity and Tolerability in Patients With Advanced and/or Metastatic Liposarcoma Who Have Relapsed Following Standard Therapies or for Whom no Standard Therapy Exists Completed NCT01692496 Phase 2 Pazopanib
3 A Phase II Single Arm Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well-Differentiated or Dedifferentiated Liposarcoma Recruiting NCT03096912 Phase 2 Ribociclib
4 Efficacy and Safety of Plitidepsin in Patients With Advanced Unresectable or Metastatic, Relapsed/Refractory, Dedifferentiated Liposarcoma (DLPS): an Exploratory Phase II Multicenter Trial Terminated NCT01876043 Phase 2 plitidepsin
5 The FGF/FGFR Signalling Pathway: a Novel Therapeutic Target in Liposarcomas Recruiting NCT03303885
6 REtroperitoneal SArcoma Registry (RESAR): Prospective Collection of Primary Retroperitoneal Sarcoma Patient's Data, Radiological and Pathological Material for the TransAtlantic Retroperitoneal Sarcoma Working Group Recruiting NCT03838718

Search NIH Clinical Center for Well-Differentiated Liposarcoma

Genetic Tests for Well-Differentiated Liposarcoma

Anatomical Context for Well-Differentiated Liposarcoma

MalaCards organs/tissues related to Well-Differentiated Liposarcoma:

40
Adipocyte, Breast, Bone, Tongue, Heart, Ovary, Colon

Publications for Well-Differentiated Liposarcoma

Articles related to Well-Differentiated Liposarcoma:

(show top 50) (show all 862)
# Title Authors PMID Year
1
Oral liposarcoma in elderly: Case report and literature analysis. 61
32028409 2020
2
From head and neck lipoma to liposarcoma: a wide spectrum of differential diagnoses and their therapeutic implications. 61
32011399 2020
3
Qualitative evaluation of MRI features of lipoma and atypical lipomatous tumor: results from a multicenter study. 61
31965239 2020
4
Lipomatous Tumors in Pediatric Patients: A Retrospective Analysis of 50 cases. 61
31282548 2020
5
What's new in adipocytic neoplasia? 61
31501988 2020
6
[Resection of soft tissue tumours : Pitfalls, typical complications and prevention strategies]. 61
31974631 2020
7
Expanding the Differential of Cutaneous Epithelioid Tumors: A Case of Dedifferentiated Liposarcoma with Epithelioid Features Involving the Skin and Review of the Literature. 61
31995237 2020
8
MicroRNA expression and DNA methylation profiles do not distinguish between primary and recurrent well-differentiated liposarcoma. 61
31971976 2020
9
Gluteal liposarcoma presenting as sciatic hernia: A case report and review of literature. 61
32006905 2020
10
Surgical management of truncal and extremities atypical lipomatous tumors/well-differentiated liposarcoma: A systematic review of the literature. 61
32029218 2020
11
ASO Author Reflections: Recurrent Retroperitoneal Well-Differentiated Liposarcoma. 61
30556116 2019
12
Deep-seated Hibernoma of Thigh: A Rare Benign Adipocytic Tumor. 61
31779762 2019
13
Molecular Characterization of a Rare Dedifferentiated Liposarcoma With Rhabdomyosarcomatous Differentiation in a 24 Year Old. 61
31801397 2019
14
Primary gastrointestinal Liposarcoma - a Clinicopathologic study of 8 cases of a rare entity. 61
31884085 2019
15
Atypical lipomatous tumour/well-differentiated liposarcoma and de-differentiated liposarcoma in patients aged ≤ 40 years: a study of 116 patients. 61
31471922 2019
16
Primary Sarcomas of the Larynx: A Single Institutional Experience with Ten Cases. 61
31813100 2019
17
Para-anal lipoma as a rare consequence to perineal trauma. Case-report and review of the literature. 61
29734868 2019
18
Radiomics approach to distinguish between well differentiated liposarcomas and lipomas on MRI. 61
31747074 2019
19
Low-grade Osteosarcomatous Dedifferentiation of an Atypical Lipomatous Tumor in a Pediatric Patient. 61
31739757 2019
20
Concurrent bariatric surgery and surgical resection of massive localized lymphedema of the thigh. A case report. 61
31687133 2019
21
Coexistance of a well differentiated liposarcoma and dedifferentiated low grade myxofibrosarcoma of the scrotum. A rare case and review of the literature. 61
32007114 2019
22
Diagnostic Utility and Limitations of Immunohistochemistry of p16, CDK4, and MDM2 and Automated Dual-color In Situ Hybridization of MDM2 for the Diagnosis of Challenging Cases of Dedifferentiated Liposarcoma. 61
31145104 2019
23
Surgical treatment for giant retroperitoneal well-differentiated liposarcoma (WDLPS): case report and literature review. 61
32007117 2019
24
Giant atypical lipomatous tumor/well-differentiated liposarcoma affects lower limb activity: A case report. 61
31626141 2019
25
Primary Atypical Lipomatous Tumor of the Orbit. 61
31875115 2019
26
Case of atypical lipomatous tumor: Possible usefulness of ultrasonography for diagnosis. 61
31062420 2019
27
Advances in soft-tissue sarcoma - There are no mistakes, only lessons to learn! 61
31807494 2019
28
The transition of tissue inhibitor of metalloproteinases from -4 to -1 induces aggressive behavior and poor patient survival in dedifferentiated liposarcoma via YAP/TAZ activation. 61
31074490 2019
29
Retroperitoneal Well-Differentiated Liposarcoma With Uterine-Type Leiomyomatous Differentiation: A First Case Report With Literature Analysis of Soft Tissue Sarcomas With Dual Lipomatous and Low-Grade Smooth Muscle Differentiation. 61
31131653 2019
30
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma With Features Mimicking Spindle Cell Lipoma. 61
31672072 2019
31
[A Case of Spermatic Cord Liposarcoma Difficult to Distinguish from Inguinal Hernia]. 61
31697883 2019
32
Double minute chromosomes harboring MDM2 amplification in a pediatric atypical lipomatous tumor. 61
30887579 2019
33
Retroperitoneal Liposarcoma with Multilocular Cysts. 61
31911764 2019
34
Co-expression of MDM2 and CDK4 in transformed human mesenchymal stem cells causes high-grade sarcoma with a dedifferentiated liposarcoma-like morphology. 61
31160689 2019
35
Dedifferentiated liposarcoma of the thyroid gland: A case report. 61
31384458 2019
36
Sonographic Appearances of Liposarcoma: Correlations with Pathologic Subtypes. 61
31202456 2019
37
The degree of sclerosis is associated with prognosis in well-differentiated liposarcoma of the retroperitoneum. 61
31206726 2019
38
Well-Differentiated Liposarcoma (Atypical Lipomatous Tumor) Presenting as an Esophageal Polyp. 61
29349606 2019
39
Adipogenesis induces growth inhibition of dedifferentiated liposarcoma. 61
31069877 2019
40
Genomic Evolutionary Patterns of Leiomyosarcoma and Liposarcoma. 61
31164371 2019
41
A huge pancreatic lipoma mimicking a well-differentiated liposarcoma: A case report and systematic literature review. 61
31531331 2019
42
Chest wall lipoma mimicking intrathoracic mass: Imaging with surgical correlation. 61
31193853 2019
43
Resection of a huge mediastinal well-differentiated liposarcoma involving left thoracic cavity. 61
31387607 2019
44
Developing a clinical scoring system to differentiate deep-seated atypical lipomatous tumor from lipoma of soft tissue. 61
30711441 2019
45
Hibernoma: A missed diagnosis!! 61
31361241 2019
46
Personalizing surgical margins in retroperitoneal sarcomas: an update. 61
31159625 2019
47
[Oesophagus polyps: Giant fibrovascular polyp of the oesophagus disappears!] 61
31003707 2019
48
Vocal cord inflammatory myofibroblastic tumor with mucoid deposits harboring TIMP3-ALK fusion: A potential diagnostic pitfall. 61
31215130 2019
49
Lipomas of the Oral Cavity: Utility of MDM2 and CDK4 in Avoiding Overdiagnosis as Atypical Lipomatous Tumor. 61
29748845 2019
50
Natural history of well-differentiated liposarcoma of the extremity compared to patients treated with surgery. 61
31196499 2019

Variations for Well-Differentiated Liposarcoma

Expression for Well-Differentiated Liposarcoma

Search GEO for disease gene expression data for Well-Differentiated Liposarcoma.

Pathways for Well-Differentiated Liposarcoma

Pathways related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.96 SS18 HMGA2 FUS EWSR1
2 11.37 SS18 MDM2 HMGA2 FUS EWSR1 DDIT3
3 11.2 MDM2 CDKN2A CDK4
4 10.64 MDM2 CDKN2A CDK4

GO Terms for Well-Differentiated Liposarcoma

Cellular components related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.83 SYT1 PPIAL4G PPIAL4F MUC1 MDM2 KRT7
2 senescence-associated heterochromatin focus GO:0035985 8.62 HMGA2 CDKN2A

Biological processes related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amyloid fibril formation GO:1990000 9.16 MDM2 CDKN2A
2 chondrocyte proliferation GO:0035988 8.96 HMGA2 DDR2
3 senescence-associated heterochromatin focus assembly GO:0035986 8.62 HMGA2 CDKN2A

Sources for Well-Differentiated Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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