ALT
MCID: WLL039
MIFTS: 44

Well-Differentiated Liposarcoma (ALT)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Well-Differentiated Liposarcoma

MalaCards integrated aliases for Well-Differentiated Liposarcoma:

Name: Well-Differentiated Liposarcoma 12 58 15 17
Atypical Lipomatous Tumor 12 58 17
Atypical Lipoma 58 70
Liposarcoma, Well Differentiated 70
Pleomorphic Lipoma 70
Wdls 58
Alt 58

Characteristics:

Orphanet epidemiological data:

58
well-differentiated liposarcoma
Inheritance: Not applicable; Prevalence: 1-9/1000000 (Europe); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

Disease Ontology 12 DOID:5690
MeSH 44 D008080
NCIt 50 C4250
SNOMED-CT 67 28655007
ICD10 via Orphanet 33 C49.9
UMLS via Orphanet 71 C1370889
Orphanet 58 ORPHA99971
SNOMED-CT via HPO 68 39539005 95325000
UMLS 70 C0205823 C1266129 C1370889

Summaries for Well-Differentiated Liposarcoma

Disease Ontology : 12 A liposarcoma that is characterized as a slow growing, painless tumor usually located in the retroperitoneum or the limbs and derives from proliferating mature adipocytes.

MalaCards based summary : Well-Differentiated Liposarcoma, also known as atypical lipomatous tumor, is related to pleomorphic lipoma and soft tissue sarcoma. An important gene associated with Well-Differentiated Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are MicroRNAs in cancer and DNA Damage Response. The drugs Palbociclib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include tongue, smooth muscle and colon, and related phenotypes are subcutaneous nodule and gastrointestinal dysmotility

Related Diseases for Well-Differentiated Liposarcoma

Diseases related to Well-Differentiated Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 375)
# Related Disease Score Top Affiliating Genes
1 pleomorphic lipoma 31.7 TSPAN31 SERPINA3 MDM2 HMGA2 CDK4 CD34
2 soft tissue sarcoma 31.4 TP53 MDM2
3 liposarcoma 31.3 TSPAN31 TP53 MDM2 HMGA2 FUS FRS2
4 lipomatosis, multiple 31.2 TSPAN31 SERPINA3 MDM2 HMGA2 FUS EWSR1
5 inflammatory liposarcoma 31.1 MDM2 CDKN2A CD34
6 infiltrating lipoma 31.1 MDM2 HMGA2 CDK4 CD34
7 lipoblastoma 31.1 MDM2 CDK4
8 osteogenic sarcoma 31.1 TP53 MDM2 CDKN2A CDK4
9 spindle cell lipoma 31.0 MDM2 CDK4 CD34
10 fibrous histiocytoma 30.9 SERPINA3 FUS EWSR1 CD34
11 juxtacortical osteosarcoma 30.9 MDM2 CDK4
12 spindle cell liposarcoma 30.9 MDM2 DDIT3 CDK4 CD34
13 sclerosing liposarcoma 30.9 MDM2 FUS CD34
14 spindle cell sarcoma 30.8 SERPINA3 MUC1 MDM2 KRT7 EWSR1 CD34
15 mediastinum liposarcoma 30.8 MDM2 CDKN2A CDK4
16 malignant fibrous histiocytoma 30.7 TP53 SERPINA3 MUC1 MDM2 EWSR1 DDIT3
17 myxoid liposarcoma 30.6 TP53 MDM2 HMGA2 FUS EWSR1 DDIT3
18 embryonal sarcoma 30.6 TP53 SERPINA3 MDM2 CDK4
19 li-fraumeni syndrome 30.6 TP53 MDM2 CDKN2A CDK4
20 mesenchymal cell neoplasm 30.6 TP53 SERPINA3 HMGA2 EWSR1 CD34
21 familial retinoblastoma 30.5 TSPAN31 TP53 MDM2 CDKN2A CDK4
22 glomus tumor 30.5 TP53 MUC1 CDKN2A CD34
23 pleomorphic liposarcoma 30.5 SERPINA3 MUC1 MDM2 FUS EWSR1 DDIT3
24 neurofibroma 30.5 TP53 MUC1 CDKN2A CD34
25 sarcoma 30.5 TP53 MUC1 MDM2 FUS EWSR1 DDIT3
26 inflammatory myofibroblastic tumor 30.4 TP53 MUC1 MDM2 CDK4 CD34
27 hemangioma 30.4 TP53 MUC1 KRT7 CD34
28 angiosarcoma 30.4 TP53 MUC1 MDM2 KRT7 CD34
29 ring chromosome 30.4 TP53 MDM2 HMGA2 EWSR1 CDK4
30 mixed liposarcoma 30.4 MDM2 FUS DDIT3 CDK4 CD34
31 chondrosarcoma 30.4 SERPINA3 MUC1 MDM2 EWSR1 CDK4
32 leiomyosarcoma 30.3 TP53 SERPINA3 MUC1 MDM2 HMGA2 CDKN2A
33 cellular myxoid liposarcoma 30.2 SERPINA3 MDM2 FUS EWSR1 DDIT3 CDK4
34 dedifferentiated liposarcoma 30.2 TSPAN31 TP53 SERPINA3 MUC1 MIR100 MDM2
35 connective tissue benign neoplasm 30.2 TP53 SERPINA3 MDM2 EWSR1 CDK4 CD34
36 myxofibrosarcoma 30.2 TP53 SERPINA3 MUC1 MDM2 FUS EWSR1
37 rhabdomyosarcoma 30.1 TP53 MDM2 KRT7 HMGA2 FUS EWSR1
38 cervical basaloid squamous cell carcinoma 10.5 KRT7 CDKN2A
39 actinic cheilitis 10.5 TP53 MDM2
40 vulvar intraepithelial neoplasia 10.5 TP53 CDKN2A
41 inverted transitional papilloma 10.5 KRT7 CDKN2A
42 diffuse lipomatosis 10.5 MDM2 CDK4
43 ring chromosome 7 10.5 TP53 MDM2 CDK4
44 anal canal paget's disease 10.5 KRT7 CDKN2A
45 aortic malignant tumor 10.5 MDM2 CD34
46 cervical mucinous adenocarcinoma 10.5 KRT7 HMGA2
47 scrotum paget's disease 10.5 MUC1 KRT7
48 esophagus verrucous carcinoma 10.5 TP53 MDM2 CDKN2A
49 pancreatic signet ring cell adenocarcinoma 10.5 TP53 MUC1
50 verrucous carcinoma 10.5 TP53 MDM2 CDKN2A

Graphical network of the top 20 diseases related to Well-Differentiated Liposarcoma:



Diseases related to Well-Differentiated Liposarcoma

Symptoms & Phenotypes for Well-Differentiated Liposarcoma

Human phenotypes related to Well-Differentiated Liposarcoma:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482
2 gastrointestinal dysmotility 58 31 occasional (7.5%) Occasional (29-5%) HP:0002579
3 abnormal renal physiology 58 31 occasional (7.5%) Occasional (29-5%) HP:0012211

MGI Mouse Phenotypes related to Well-Differentiated Liposarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.17 CD34 CDK4 CDKN2A DDIT3 DDR2 MDM2

Drugs & Therapeutics for Well-Differentiated Liposarcoma

Drugs for Well-Differentiated Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Palbociclib Approved, Investigational Phase 2 571190-30-2 5005498 5330286 11431660
2 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of CDK4/6 Inhibition (Palbociclib) Combined With PD-1 Blockade (INCMGA00012) in Patients With Advanced Well-differentiated and/or Dedifferentiated Liposarcoma Recruiting NCT04438824 Phase 2 INCMGA00012;Palbociclib

Search NIH Clinical Center for Well-Differentiated Liposarcoma

Genetic Tests for Well-Differentiated Liposarcoma

Anatomical Context for Well-Differentiated Liposarcoma

MalaCards organs/tissues related to Well-Differentiated Liposarcoma:

40
Tongue, Smooth Muscle, Colon, Adipocyte, Pancreas, Breast, Skin

Publications for Well-Differentiated Liposarcoma

Articles related to Well-Differentiated Liposarcoma:

(show top 50) (show all 933)
# Title Authors PMID Year
1
Well-differentiated liposarcoma of the spermatic cord: A case report. 61
33643848 2021
2
Dermoid cyst in the subcutaneous tissues of the back: A rare case with multimodal imaging and pathologic correlation. 61
33732406 2021
3
Primary Sarcomas of the Larynx: A Clinicopathologic Study of 27 Cases. 61
33686585 2021
4
MDM2 Amplified Sarcomas: A Literature Review. 61
33799733 2021
5
Liposarcoma in children and young adults: a clinicopathologic and molecular study of 23 cases in one of the largest institutions of China. 61
33738541 2021
6
Clinical Application of Chromosome Microarray Analysis in the Diagnosis of Lipomatous Tumors. 61
33734108 2021
7
Establishment and characterization of NCC-DDLPS3-C1: a novel patient-derived cell line of dedifferentiated liposarcoma. 61
33677797 2021
8
A Rapid and Cost-Effective Gene Expression Assay for the Diagnosis of Well-Differentiated and Dedifferentiated Liposarcomas. 61
33346147 2021
9
Multiple well-differentiated retroperitoneal liposarcomas with different patterns of appearance on computed tomography: A case report. 61
33728310 2021
10
Atypical Pleomorphic Lipomatous Tumor: Expanding Our Current Understanding in a Clinicopathologic Analysis of 64 Cases. 61
33782225 2021
11
Nuclear expression of MDM2 in hibernoma: a potential diagnostic pitfall. 61
32815035 2021
12
Establishment and characterization of a novel cell line, NCC-DDLPS2-C1, derived from a patient with dedifferentiated liposarcoma. 61
33555519 2021
13
Limb Salvage Resection of Massive Dedifferentiated Thigh Liposarcoma in a Patient Lost to Follow-Up. 61
33754090 2021
14
Preoperative Biopsy in Patients with Retroperitoneal Sarcoma: Usage and Outcomes in a National Cohort. 61
33591480 2021
15
The recurrence of well-differentiated liposarcoma from benign giant intramuscular lipoma: A case (CARE-compliant) report. 61
33578611 2021
16
The Utility of Perilipin in Liposarcomas: PLIN1 Differentiates Round Cell Liposarcoma From Other Round Cell Sarcomas. 61
32205741 2021
17
Recent Advancement in Atypical Lipomatous Tumor Research. 61
33498189 2021
18
Surgical management of a large retroperitoneal liposarcoma: A case study. 61
33318934 2021
19
Resection of a giant retroperitoneal lipoma herniating through the inguinal canal. 61
33500309 2021
20
Prediction of Histologic Subtype and FNCLCC Grade by SUVmax Measured on 18F-FDG PET/CT in Patients with Retroperitoneal Liposarcoma. 61
33505228 2021
21
Prognostic significance of the MDM2/HMGA2 ratio and histological tumor grade in dedifferentiated liposarcoma. 61
33111425 2021
22
Recent advances in the understanding and management of liposarcoma. 61
33659920 2021
23
Clinical features of multiply recurrent retroperitoneal liposarcoma: A single-center experience. 61
33191070 2021
24
Parosteal osteosarcoma associated with a low-grade component mimicking well-differentiated liposarcoma: a case report. 61
32564106 2021
25
Testicular, Spermatic Cord, and Scrotal Soft Tissue Sarcomas: Treatment Outcomes and Patterns of Failure. 61
33746565 2021
26
Recent developments in gastroesophageal mesenchymal tumours. 61
33382494 2021
27
Resection of a giant mediastinal atypical lipomatous tumor involving the esophagus. 61
33505654 2021
28
Evaluating the Impact of Surveillance Follow-Up Intervals in Patients Following Resection of Primary Well-Differentiated Liposarcoma of the Retroperitoneum. 61
32409969 2021
29
The MDM2 inducible promoter folds into four-tetrad antiparallel G-quadruplexes targetable to fight malignant liposarcoma. 61
33410915 2021
30
ASO Author Reflections: Surveillance After Resection of Retroperitoneal Well-Differentiated Liposarcoma: A Balancing Act Between Earlier Recurrence Detection, Patient Anxiety, and Health Care Resource Expenditure. 61
32409970 2020
31
Synchronous Renal Dedifferentiated Liposarcoma and Retroperitoneal Well-Differentiated Liposarcoma: A Case Report With Literature Review. 61
33355009 2020
32
[A Case of Lipoma Arising from the Mesentery Proper That Had Difficulty in Differential Diagnosis with Well-Differentiated Liposarcoma]. 61
33468834 2020
33
Pilot study to differentiate lipoma from atypical lipomatous tumour/well-differentiated liposarcoma using MR radiomics-based texture analysis. 61
32424704 2020
34
What Are the Results of Resection of Localized Dedifferentiated Liposarcomas in the Extremities? 61
33112583 2020
35
A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study. 61
32701199 2020
36
A rare case of liposarcoma of the spermatic cord. 61
33102038 2020
37
Rare MDM2 amplification in a fat-predominant angiomyolipoma. 61
32409886 2020
38
Giant retroperitoneal liposarcoma with a maximum diameter of 37 cm: a case report and review of literature. 61
33178780 2020
39
Inflammatory Variant of Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Buccal Mucosa: An Overview and Case Report with a 10-Year Follow-Up. 61
33091145 2020
40
Dedifferentiated liposarcoma with heterologous spindle cell rhabdomyoblastic de-differentiation: An unusual pattern expanding the morphological spectrum. 61
33154322 2020
41
Dedifferentiated Liposarcoma With Meningothelial-Like Whorls: Five Additional Cases and Review of the Literature. 61
32419561 2020
42
Discrimination of well-differentiated liposarcoma from benign lipoma on sonography: an uncontrolled retrospective study. 61
32960385 2020
43
Well-differentiated liposarcoma primary from thymic stroma: Case report and literature review. 61
32791064 2020
44
[Video-assisted Thoracic Surgery of an Hourglass Transmural Lipoma;Report of a Case]. 61
32879280 2020
45
Atypical Spindle Cell Lipomatous Lesion Resected From Patient With History of CLL. 61
32683914 2020
46
Primary Sarcomas of the Larynx: A Single Institutional Experience with Ten Cases. 61
31813100 2020
47
Recurrent retroperitoneal sarcomas: Clinical outcomes of surgical treatment and prognostic factors. 61
32950313 2020
48
Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma of the Orbit: Three Cases and Review of the Literature. 61
32991496 2020
49
An extremely rare case of rapidly growing mediastinal well-differentiated liposarcoma with a sclerosing variant: a case report. 61
32621145 2020
50
A Rare Case of Vulvar Hibernoma Treated With Resection. 61
32789056 2020

Variations for Well-Differentiated Liposarcoma

Expression for Well-Differentiated Liposarcoma

Search GEO for disease gene expression data for Well-Differentiated Liposarcoma.

Pathways for Well-Differentiated Liposarcoma

GO Terms for Well-Differentiated Liposarcoma

Cellular components related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 HMGA2 CDKN2A

Biological processes related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.88 TP53 MDM2 HMGA2 CDKN2A CD34
2 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.54 TP53 MUC1 MDM2
3 chondrocyte proliferation GO:0035988 9.52 HMGA2 DDR2
4 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990440 9.51 TP53 DDIT3
5 amyloid fibril formation GO:1990000 9.49 MDM2 CDKN2A
6 ER overload response GO:0006983 9.46 TP53 DDIT3
7 cellular response to UV-C GO:0071494 9.43 TP53 MDM2
8 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.4 TP53 MUC1
9 regulation of tissue remodeling GO:0034103 9.32 TP53 DDR2
10 cellular response to actinomycin D GO:0072717 9.26 TP53 MDM2
11 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043618 9.16 MUC1 DDIT3
12 senescence-associated heterochromatin focus assembly GO:0035986 8.96 HMGA2 CDKN2A
13 positive regulation of cell cycle arrest GO:0071158 8.8 TP53 HMGA2 CDKN2A

Molecular functions related to Well-Differentiated Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.65 TP53 HMGA2 DDIT3 CDKN2A CD34
2 disordered domain specific binding GO:0097718 9.33 TP53 MDM2 CDKN2A
3 MDM2/MDM4 family protein binding GO:0097371 9.32 TP53 CDKN2A
4 transcription coregulator activity GO:0003712 9.26 MUC1 HMGA2 FUS EWSR1
5 p53 binding GO:0002039 8.92 TP53 MUC1 MDM2 CDKN2A

Sources for Well-Differentiated Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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