MCID: WLL006
MIFTS: 55

Wells Syndrome

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Wells Syndrome

MalaCards integrated aliases for Wells Syndrome:

Name: Wells Syndrome 54 60 74
Eosinophilic Cellulitis 54 60
Bullous Cellulitis with Eosinophilia 54
Wells' Syndrome 54

Characteristics:

Orphanet epidemiological data:

60
wells syndrome
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

ICD10 34 L98.3
MESH via Orphanet 46 C536693
ICD10 via Orphanet 35 L98.3
UMLS via Orphanet 75 C0343101
Orphanet 60 ORPHA901
UMLS 74 C0343101

Summaries for Wells Syndrome

NIH Rare Diseases : 54 Wells syndrome is a rare eosinophilic disorder that primarily affects the skin. Affected people typically develop a skin rash that is often preceded by itching or burning skin. The rash consists of raised, red, swollen areas that may be warm to the touch. The symptoms generally come on rapidly and may last four to eight weeks. In some cases, the rash may recur (occur frequently or repeatedly) for years. The exact underlying cause of Wells syndrome is currently unknown; however, some scientists believe that it may be an autoimmune reaction. Oral or topical corticosteroids are commonly used to treat Wells syndrome, although antifungal drugs, antibiotics, immunosuppressants, and/or antihistamines have also been used with varying degrees of success.

MalaCards based summary : Wells Syndrome, also known as eosinophilic cellulitis, is related to muckle-wells syndrome and cryopyrin-associated periodic syndrome. An important gene associated with Wells Syndrome is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Rilonacept and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells, and related phenotypes are pruritus and cellulitis

CDC : 3 Many people in the United States receive their water from private ground water wells. EPA regulations that protect public drinking water systems do not apply to privately owned wells. As a result, owners of private wells are responsible for ensuring that their water is safe from contaminants. Here you may find information on the basics of wells, proper methods of siting and location for wells, all about testing and how often to test a well, proper treatment of wells and maintenance of wells , information on well retirement, common diseases and contaminants associated with wells, emergency treatment of wells, and answers to frequently asked questions about wells.

Related Diseases for Wells Syndrome

Diseases related to Wells Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 muckle-wells syndrome 33.2 CRP IL1B IL1R1 MEFV NLRP3 TNFRSF1A
2 cryopyrin-associated periodic syndrome 31.9 CRP IL1R1 NLRP3
3 familial cold autoinflammatory syndrome 1 31.1 IL1B IL1R1 MEFV NLRP3 TNFRSF1A
4 cellulitis 30.7 IL1R1 IL5 RNASE3
5 onchocerciasis 30.2 IL2 IL5 RNASE3
6 hypereosinophilic syndrome 29.8 IL2RA IL5 RNASE3
7 joint disorders 29.6 IL1B IL1R1 IL1RAPL2
8 amyloidosis 29.6 MEFV NLRP3 TNFRSF1A
9 cold urticaria 29.5 IL1R1 IL1RAPL2 NLRP3 RNASE3
10 tetanus 29.4 IL2 IL2RA IL5
11 ulcerative colitis 29.4 CRP CXCL8 IL1B IL2
12 cinca syndrome 29.4 IL1B IL1R1 MEFV NLRP3
13 mycosis fungoides 29.2 IL2 IL2RA IL5
14 multiple sclerosis 28.8 IL1B IL2 IL2RA TNFRSF1A
15 asthma 28.5 CXCL8 IL1B IL1R1 IL2RA IL5 NLRP3
16 ankyloblepharon-ectodermal defects-cleft lip/palate 12.0
17 rapp-hodgkin syndrome 10.6
18 exudative glomerulonephritis 10.4 CXCL8 IL1B
19 mycobacterium kansasii 10.4 CXCL8 NLRP3
20 recurrent corneal erosion 10.4 CXCL8 IL1B
21 myasthenic syndrome, congenital, 1a, slow-channel 10.4 CRP CXCL8
22 psoriatic juvenile idiopathic arthritis 10.4 MEFV NLRP3
23 toxicodendron dermatitis 10.4 CXCL8 IL2
24 bacterial infectious disease 10.3 CRP CXCL8 IL1B
25 streptococcal toxic-shock syndrome 10.3 CXCL8 IL2
26 silicosis 10.3 CXCL8 IL1B NLRP3
27 pyuria 10.3 CRP CXCL8
28 autoimmune vasculitis 10.3 IL1B IL2
29 pneumoconiosis 10.3 CXCL8 IL1B NLRP3
30 vulvar vestibulitis syndrome 10.3 IL1B IL1R1 NLRP3
31 loeffler endocarditis 10.3 IL5 RNASE3
32 stomatitis 10.3 IL1B MEFV TP63
33 perinatal necrotizing enterocolitis 10.3 CRP CXCL8 IL1B
34 cervical adenitis 10.3 IL1B MEFV NLRP3
35 exanthem 10.3 CRP IL2 NLRP3
36 pyelonephritis 10.3 CRP CXCL8 IL1B
37 leptospirosis 10.3 CRP CXCL8 IL1B
38 crohn's colitis 10.3 CXCL8 IL1B IL2
39 preterm premature rupture of the membranes 10.3 CRP CXCL8 IL1B
40 blau syndrome 10.3 IL1B MEFV NLRP3
41 appendicitis 10.3 CRP CXCL8 IL1B
42 uremic pruritus 10.3 CRP IL1B IL2
43 otitis media 10.3 CXCL8 IL1B RNASE3
44 pulmonary edema 10.2 CRP CXCL8 IL1B
45 pyoderma gangrenosum 10.2 CXCL8 MEFV NLRP3
46 bacterial meningitis 10.2 CRP CXCL8 IL1B
47 prostatitis 10.2 CXCL8 IL1B IL2
48 chlamydia 10.2 CRP CXCL8 IL1B
49 sleep apnea 10.2 CRP CXCL8 IL1B
50 tonsillitis 10.2 CXCL8 IL1B IL2

Graphical network of the top 20 diseases related to Wells Syndrome:



Diseases related to Wells Syndrome

Symptoms & Phenotypes for Wells Syndrome

Human phenotypes related to Wells Syndrome:

60 33 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 60 33 hallmark (90%) Very frequent (99-80%) HP:0000989
2 cellulitis 60 33 hallmark (90%) Very frequent (99-80%) HP:0100658
3 abnormal blistering of the skin 60 33 frequent (33%) Frequent (79-30%) HP:0008066
4 edema 60 33 frequent (33%) Frequent (79-30%) HP:0000969
5 skin vesicle 60 33 frequent (33%) Frequent (79-30%) HP:0200037
6 eosinophilia 60 33 frequent (33%) Frequent (79-30%) HP:0001880
7 fever 60 33 occasional (7.5%) Occasional (29-5%) HP:0001945
8 arthralgia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002829
9 vasculitis 60 Excluded (0%)

GenomeRNAi Phenotypes related to Wells Syndrome according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.72 CXCL8 IL1B IL2 IL2RA NLRP3 TNFRSF1A
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.72 CXCL8 IL1B IL2 IL2RA NLRP3 TNFRSF1A

MGI Mouse Phenotypes related to Wells Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 CRP FGFR2 HNRNPAB IL1B IL1R1 IL2
2 growth/size/body region MP:0005378 10.14 FGFR2 IL1B IL1R1 IL2 IL2RA IL5
3 immune system MP:0005387 10.06 CRP FGFR2 IL1B IL1R1 IL2 IL2RA
4 digestive/alimentary MP:0005381 9.98 FGFR2 IL2 IL2RA IL5 NLRP3 TNFRSF1A
5 integument MP:0010771 9.86 FGFR2 IL1B IL1R1 MEFV NLRP3 RACK1
6 liver/biliary system MP:0005370 9.7 FGFR2 IL1R1 IL2 IL5 MEFV NLRP3
7 neoplasm MP:0002006 9.5 FGFR2 IL1B IL1R1 IL2 IL5 TNFRSF1A
8 respiratory system MP:0005388 9.17 FGFR2 IL1R1 IL2 IL2RA IL5 TNFRSF1A

Drugs & Therapeutics for Wells Syndrome

Drugs for Wells Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rilonacept Approved, Investigational Phase 3,Phase 2 501081-76-1 104924
2 Antibodies Phase 3,Phase 2
3 Immunoglobulins Phase 3,Phase 2
4 Antibodies, Monoclonal Phase 3,Phase 2
5 Immunologic Factors Phase 3
6 Vaccines Phase 3
7 Anti-Inflammatory Agents Phase 3,Phase 2
8 Interleukin 1 Receptor Antagonist Protein Phase 2

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Efficacy, Safety, and Tolerability of ACZ885 in Patients With Muckle-Wells Syndrome Completed NCT00465985 Phase 3 ACZ885;Placebo
2 Efficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease Completed NCT00685373 Phase 3 Canakinumab (ACZ885)
3 Efficacy and Safety Study of Canakinumab Administered for 6 Months (24 Weeks) in Japanese Patients With Cryopyrin-associated Periodic Syndromes Followed by an Extension Phase Completed NCT00991146 Phase 3 canakinumab
4 Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease Completed NCT01576367 Phase 3
5 Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease Completed NCT01302860 Phase 3 ACZ885
6 Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS) Completed NCT00288704 Phase 3 rilonacept 160 mg;Placebo;rilonacept 160 mg
7 A Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 Studies Completed NCT02334748 Phase 3 canakinumab
8 The Safety and Efficacy of Canakinumab in Patients Aged 4 Years or Older Diagnosed With Cryopyrin-associated Periodic Syndromes (CAPS) in Canada Completed NCT01105507 Phase 3 canakinumab (company code: ACZ885D)
9 Safety and Tolerability of Rilonacept in Muckle-Wells Syndrome (MWS) or Schnitzler Syndrome (SchS) Completed NCT01045772 Phase 2 rilonacept
10 Interleukin-1 Trap to Treat Autoinflammatory Diseases Completed NCT00094900 Phase 2 IL-1 Trap
11 Safety, Efficacy, Pharmacokinetics, Pharmacodynamics of ACZ885 in Patients With NALP3 Mutations and Clinical Symptoms Completed NCT00487708 Phase 2 canakinumab
12 HL2351 CAPS Phase II Study Terminated NCT02853084 Phase 2 HL2351
13 A Pilot Study of XOMA 052 in Familial Cold Autoinflammatory Syndrome / Muckle-Wells Syndrome and Behcet's Disease Withdrawn NCT01211977 Phase 1, Phase 2 XOMA 052
14 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
15 Clinical Outcomes and Safety: A Registry Study of Ilaris (Canakinumab) Patients Completed NCT01213641

Search NIH Clinical Center for Wells Syndrome

Genetic Tests for Wells Syndrome

Anatomical Context for Wells Syndrome

MalaCards organs/tissues related to Wells Syndrome:

42
Skin, Testes, T Cells, Brain, Kidney, Colon, Thyroid

Publications for Wells Syndrome

Articles related to Wells Syndrome:

(show top 50) (show all 304)
# Title Authors Year
1
Is chemotherapy the best option for chronic lymphocytic leukemia associated Wells' syndrome? Reply to "Case of Wells' syndrome: A rare association with the clinical course of chronic lymphocytic leukemia". ( 30362593 )
2019
2
Case of Wells' syndrome: A rare association with the clinical course of chronic lymphocytic leukemia. ( 30063068 )
2019
3
Early canakinumab therapy for the sensorineural deafness in a family with Muckle-Wells syndrome due to a novel mutation of NLRP3 gene. ( 30338413 )
2019
4
Muckle-Wells Syndrome Across Four Generations in One Czech Family: Natural Course of the Disease. ( 31057541 )
2019
5
Wells syndrome and Chronic Spontaneous Urticaria: report of four cases successfully treated with omalizumab. ( 31106467 )
2019
6
Wells' Syndrome Induced by Ustekinumab. ( 30685913 )
2019
7
A Case of Amyloidosis Caused by Sporadic Muckle-Wells Syndrome: Response to Treatment With Anakinra. ( 29239931 )
2018
8
De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome. ( 29922587 )
2018
9
Pediatric Wells syndrome (eosinophilic cellulitis) after vaccination: A case report and review of the literature. ( 29998475 )
2018
10
Wells syndrome (eosinophilic cellulitis) caused by adrenal insufficiency and relieved by cortisone supplementation. ( 29398098 )
2018
11
Eosinophilic infiltrate resembling eosinophilic cellulitis (Wells syndrome) in a patient with mycosis fungoides. ( 29469767 )
2018
12
Eosinophilic cellulitis (Wells syndrome) successfully treated with mepolizumab. ( 29892672 )
2018
13
Resolution of unilateral sensorineural hearing loss in a pediatric patient with a severe phenotype of Muckle-Wells syndrome treated with Anakinra: a case report and review of the literature. ( 29382382 )
2018
14
A Case of Muckle-Wells Syndrome due to novel NLRP3 mutation. ( 30157308 )
2018
15
Ocular Involvement in Muckle-Wells Syndrome. ( 30556770 )
2018
16
Wells' syndrome associated with eosinophilic panniculitis presenting with multiple subcutaneous nodules. ( 30325316 )
2018
17
A rare form of ankyloblepharon filiforme adnatum associated with the Hay-Wells syndrome and a c.1709T>C mutation on the TP63 gene. ( 29140732 )
2018
18
Wells syndrome secondary to influenza vaccination: A case report and review of the literature. ( 29240526 )
2018
19
Expanding the genetic profile of Hay-Wells syndrome. ( 29329681 )
2018
20
Wells' syndrome-like reaction following Argas reflexus bites. ( 29400289 )
2018
21
Wells syndrome: a case of successful treatment with omalizumab. ( 29707773 )
2018
22
Wells' Syndrome Associated with Coxsackievirus A6 Infection. ( 29972218 )
2018
23
Wells syndrome in a patient receiving adalimumab biosimilar: A case report and review of literature. ( 30058563 )
2018
24
Muckle-Wells syndrome in the setting of basal cell nevus syndrome. ( 28686751 )
2017
25
Clinical Course of Eosinophilic Cellulitis. ( 29228410 )
2017
26
Eosinophilic Cellulitis Possibly Due to Mosquito Bite With High IL-5 Production. ( 28398209 )
2017
27
Bullous Pesentation of Idiopathic Wells Syndrome (Eosinophilic Cellulitis). ( 28920134 )
2017
28
Muckle-Wells syndrome: a rare hereditary cryopyrin-associated periodic syndrome. ( 26218404 )
2017
29
Endometriosis in the setting of Muckle-Wells syndrome treated with an IL-1β antagonist. ( 28508753 )
2017
30
Muckle-Wells syndrome in Chinese patients: a single center case series. ( 28028683 )
2017
31
A Novel Mutation in the Pyrin Domain of the NOD-like Receptor Family Pyrin Domain Containing Protein 3 in Muckle-Wells Syndrome. ( 28229991 )
2017
32
Placental Transfer of Canakinumab in a Patient with Muckle-Wells Syndrome. ( 28386702 )
2017
33
Periodic fever: From Still's disease to Muckle-Wells syndrome. ( 28583784 )
2017
34
Muckle-Wells syndrome: clinical perspectives. ( 28744167 )
2017
35
Wells Syndrome with Bullous Lesions. ( 28351790 )
2017
36
Wells' Syndrome Successfully Treated with Colchicine. ( 28868003 )
2017
37
Wells syndrome associated with lung cancer. ( 28951508 )
2017
38
Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review. ( 27357601 )
2016
39
Successful treatment of eosinophilic cellulitis with dapsone. ( 27617724 )
2016
40
Chronic relapsing eosinophilic cellulitis associated, although independent in severity, with chronic lymphocytic leukemia. ( 25080091 )
2016
41
Wells' syndrome with a clinicopathological correlation associated with mantle-cell lymphoma. ( 26999270 )
2016
42
Muckle-Wells Syndrome: A Case Report with an NLRP3 T348M Mutation. ( 27435956 )
2016
43
Wells syndrome. ( 27767278 )
2016
44
Renal involvement in secondary amyloidosis of Muckle-Wells syndrome: marked improvement of renal function and reduction of proteinuria after therapy with human anti-interleukin-1β monoclonal antibody canakinumab. ( 24510061 )
2015
45
Bullous eosinophilic cellulitis with subcorneal pustules. ( 25851759 )
2015
46
Eosinophilic cellulitis. ( 25946678 )
2015
47
Wells' Syndrome Mimicking Facial Cellulitis: A Report of Two Cases. ( 26120307 )
2015
48
Life of lesions in eosinophilic cellulitis (Wells' syndrome)-a condition that may be missed at first sight. ( 25238447 )
2015
49
Idiopathic Hypereosinophilic Syndrome With Cutaneous Manifestations and Flame Figures: A Spectrum of Eosinophilic Dermatoses Whose Features Overlap With Wells' Syndrome. ( 25839890 )
2015
50
Wells syndrome associated with chronic lymphocytic leukemia. ( 26375230 )
2015

Variations for Wells Syndrome

Expression for Wells Syndrome

Search GEO for disease gene expression data for Wells Syndrome.

Pathways for Wells Syndrome

Pathways related to Wells Syndrome according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 CRP CXCL8 FGFR2 IL1B IL1R1 IL2
2
Show member pathways
13.8 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
3
Show member pathways
13.61 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
4
Show member pathways
13.47 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
5
Show member pathways
13.34 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
6
Show member pathways
13.27 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
7
Show member pathways
13.16 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
8
Show member pathways
13.03 CXCL8 IL1B IL2 MEFV NLRP3 TNFRSF1A
9 12.77 CXCL8 FGFR2 IL2 IL2RA IL5
10
Show member pathways
12.72 CXCL8 IL1B IL2 IL2RA IL5 RNASE3
11
Show member pathways
12.64 FGFR2 IL1B IL1R1 IL2 TNFRSF1A
12
Show member pathways
12.53 IL1B IL1R1 IL2 IL2RA IL5
13 12.49 IL1B IL2 IL2RA TNFRSF1A
14 12.29 IL1R1 IL2 IL2RA TNFRSF1A
15
Show member pathways
12.16 FGFR2 IL1B IL1R1 IL2 IL2RA IL5
16
Show member pathways
12.09 CXCL8 FGFR2 IL1B IL2 IL2RA IL5
17 11.97 IL1B IL1R1 TNFRSF1A
18 11.96 CXCL8 IL1B IL1R1 IL2
19 11.92 IL2 IL2RA IL5
20
Show member pathways
11.92 IL1B IL1R1 IL2 IL2RA
21
Show member pathways
11.89 HNRNPAB IL2 IL2RA
22 11.82 CXCL8 IL1B IL1R1
23 11.82 IL1B IL1R1 IL2RA IL5
24 11.81 CXCL8 IL1B IL1R1 TNFRSF1A
25
Show member pathways
11.81 IL1B IL1R1 IL2 IL2RA IL5
26 11.74 CXCL8 IL2 IL5
27 11.7 CXCL8 IL1B NLRP3
28
Show member pathways
11.66 CXCL8 IL2 IL2RA IL5
29 11.61 CXCL8 IL1B IL5
30
Show member pathways
11.56 CXCL8 IL1B IL2 TNFRSF1A
31 11.45 IL2 IL2RA IL5
32 11.39 IL1B MEFV NLRP3
33 11.36 CXCL8 IL1B IL1R1 TNFRSF1A
34 11.26 IL1B IL1R1 IL2 IL2RA IL5
35
Show member pathways
11.24 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
36 11.21 IL1B IL2 IL5
37
Show member pathways
11.16 HNRNPAB IL2 IL2RA
38 11.16 CXCL8 IL1B IL2 IL5
39 11.12 IL1B IL1R1 NLRP3
40 10.98 IL2 IL2RA IL5 TNFRSF1A
41 10.96 CRP CXCL8
42 10.96 CXCL8 FGFR2 IL1B IL2 IL5

GO Terms for Wells Syndrome

Cellular components related to Wells Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.32 CRP CXCL8 FGFR2 IL1B IL1R1 IL2

Biological processes related to Wells Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.85 CXCL8 IL1B IL1R1 IL2 IL2RA IL5
2 apoptotic process GO:0006915 9.8 FGFR2 IL1B IL2RA NLRP3 RACK1 TNFRSF1A
3 defense response to Gram-positive bacterium GO:0050830 9.75 CRP NLRP3 RNASE3
4 MAPK cascade GO:0000165 9.72 FGFR2 IL1B IL2 IL2RA IL5
5 positive regulation of T cell proliferation GO:0042102 9.7 IL1B IL2 IL2RA
6 positive regulation of interferon-gamma production GO:0032729 9.63 IL1B IL1R1 IL2
7 response to ethanol GO:0045471 9.6 FGFR2 IL2
8 regulation of regulatory T cell differentiation GO:0045589 9.58 IL2 IL2RA
9 positive regulation of immunoglobulin secretion GO:0051024 9.57 IL2 IL5
10 interleukin-2-mediated signaling pathway GO:0038110 9.56 IL2 IL2RA
11 inflammatory response GO:0006954 9.56 CRP CXCL8 IL1B IL1R1 IL5 MEFV
12 positive regulation of ceramide biosynthetic process GO:2000304 9.55 RACK1 TNFRSF1A
13 negative regulation of inflammatory response GO:0050728 9.55 IL2 IL2RA MEFV NLRP3 TNFRSF1A
14 regulation of establishment of endothelial barrier GO:1903140 9.54 IL1B TNFRSF1A
15 negative regulation of lymphocyte proliferation GO:0050672 9.51 IL2 IL2RA
16 interleukin-1 beta production GO:0032611 9.49 IL1B NLRP3
17 positive regulation of T-helper 1 cell cytokine production GO:2000556 9.48 IL1B IL1R1
18 regulation of T cell homeostatic proliferation GO:0046013 9.43 IL2 IL2RA
19 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development GO:0060529 9.4 FGFR2 TP63
20 cytokine-mediated signaling pathway GO:0019221 9.23 CXCL8 IL1B IL1R1 IL1RAPL2 IL2 IL2RA
21 positive regulation of transcription by RNA polymerase II GO:0045944 10.07 FGFR2 IL1B IL2 NLRP3 TNFRSF1A TP63

Molecular functions related to Wells Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor activity GO:0004908 8.96 IL1R1 IL1RAPL2
2 cytokine activity GO:0005125 8.92 CXCL8 IL1B IL2 IL5

Sources for Wells Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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