Aliases & Classifications for Wells Syndrome

MalaCards integrated aliases for Wells Syndrome:

Name: Wells Syndrome 53 59 73
Eosinophilic Cellulitis 53 59
Bullous Cellulitis with Eosinophilia 53
Wells' Syndrome 53

Characteristics:

Orphanet epidemiological data:

59
wells syndrome
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA901
MESH via Orphanet 45 C536693
UMLS via Orphanet 74 C0343101
ICD10 via Orphanet 34 L98.3
ICD10 33 L98.3
UMLS 73 C0343101

Summaries for Wells Syndrome

NIH Rare Diseases : 53 Wells syndrome is a rare eosinophilic disorder that primarily affects the skin. Affected people typically develop a skin rash that is often preceded by itching or burning skin. The rash consists of raised, red, swollen areas that may be warm to the touch. The symptoms generally come on rapidly and may last four to eight weeks. In some cases, the rash may recur (occur frequently or repeatedly) for years. The exact underlying cause of Wells syndrome is currently unknown; however, some scientists believe that it may be an autoimmune reaction. Oral or topical corticosteroids are commonly used to treat Wells syndrome, although antifungal drugs, antibiotics, immunosuppressants, and/or antihistamines have also been used with varying degrees of success.

MalaCards based summary : Wells Syndrome, also known as eosinophilic cellulitis, is related to ankyloblepharon-ectodermal defects-cleft lip/palate and muckle-wells syndrome. An important gene associated with Wells Syndrome is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Vaccines and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and monocytes, and related phenotypes are pruritus and cellulitis

CDC : 3 Many people in the United States receive their water from private ground water wells. EPA regulations that protect public drinking water systems do not apply to privately owned wells. As a result, owners of private wells are responsible for ensuring that their water is safe from contaminants. Here you may find information on the basics of wells, proper methods of siting and location for wells, all about testing and how often to test a well, proper treatment of wells and maintenance of wells , information on well retirement, common diseases and contaminants associated with wells, emergency treatment of wells, and answers to frequently asked questions about wells.

Related Diseases for Wells Syndrome

Diseases related to Wells Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 ankyloblepharon-ectodermal defects-cleft lip/palate 33.8 FGFR2 TP63
2 muckle-wells syndrome 32.2 CRP IL1B IL1R1 MEFV NLRP3 TNFRSF1A
3 cryopyrin-associated periodic syndrome 31.3 CRP IL1R1 NLRP3
4 familial cold autoinflammatory syndrome 1 30.9 IL1B IL1R1 MEFV NLRP3 TNFRSF1A
5 amyloidosis 30.1 MEFV NLRP3 TNFRSF1A
6 hypereosinophilic syndrome 30.1 IL2RA IL5 RNASE3
7 cellulitis 29.7 CRP IL1R1 IL5 RNASE3
8 tetanus 29.6 IL2 IL2RA IL5
9 cold urticaria 29.4 IL1R1 IL1RAPL2 NLRP3 RNASE3
10 mycosis fungoides 29.3 IL2 IL2RA IL5
11 allergic asthma 29.2 CXCL8 IL5 RNASE3
12 multiple sclerosis 28.6 IL1B IL2 IL2RA IL5 TNFRSF1A
13 ulcerative colitis 28.2 CRP CXCL8 IL1B IL2
14 asthma 27.3 CXCL8 IL1B IL1R1 IL2RA IL5 NLRP3
15 psoriatic juvenile idiopathic arthritis 10.9 MEFV NLRP3
16 inflammatory myopathy with abundant macrophages 10.8 MEFV TNFRSF1A
17 intermittent hydrarthrosis 10.8 MEFV TNFRSF1A
18 systemic onset juvenile idiopathic arthritis 10.8 IL1B MEFV
19 loeffler endocarditis 10.7 IL5 RNASE3
20 cervical adenitis 10.7 IL1B MEFV NLRP3
21 idiopathic recurrent pericarditis 10.7 MEFV TNFRSF1A
22 blau syndrome 10.7 IL1B MEFV NLRP3
23 aphthous stomatitis 10.7 IL1B MEFV NLRP3
24 erysipeloid 10.6 MEFV NLRP3
25 autoimmune myocarditis 10.6 IL1B IL2
26 periodic fever, familial, autosomal dominant 10.6 MEFV NLRP3 TNFRSF1A
27 blepharoconjunctivitis 10.6 FGFR2 RNASE3
28 cough variant asthma 10.6 IL5 RNASE3
29 recurrent corneal erosion 10.5 CXCL8 IL1B
30 mycobacterium kansasii 10.5 CXCL8 NLRP3
31 vulvar vestibulitis syndrome 10.5 IL1B IL1R1 NLRP3
32 schnitzler syndrome 10.5 IL1B IL1R1 NLRP3
33 rapp-hodgkin syndrome 10.5
34 inflammatory bowel disease 4 10.4 IL5 RNASE3
35 joint disorders 10.4 IL1B IL1R1 IL1RAPL2
36 familial cold autoinflammatory syndrome 2 10.4 CRP NLRP3
37 vernal conjunctivitis 10.4 IL2 IL2RA RNASE3
38 cow milk allergy 10.4 IL5 RNASE3
39 atopic keratoconjunctivitis 10.4 IL2 IL5 RNASE3
40 toxicodendron dermatitis 10.3 CXCL8 IL2
41 silicosis 10.3 CXCL8 IL1B NLRP3
42 pneumoconiosis 10.3 CXCL8 IL1B NLRP3
43 pyoderma gangrenosum 10.3 CXCL8 MEFV NLRP3
44 onchocerciasis 10.3 IL2 IL5 RNASE3
45 paragonimiasis 10.3 IL5 RNASE3
46 peptic esophagitis 10.3 CXCL8 IL1B
47 extrinsic allergic alveolitis 10.3 CXCL8 IL1B IL2RA
48 schistosomiasis 10.3 IL2 IL5 RNASE3
49 conjunctival disease 10.3 IL5 NLRP3 RNASE3 TNFRSF1A
50 sezary's disease 10.3 IL2 IL2RA IL5

Graphical network of the top 20 diseases related to Wells Syndrome:



Diseases related to Wells Syndrome

Symptoms & Phenotypes for Wells Syndrome

Human phenotypes related to Wells Syndrome:

59 32 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 59 32 hallmark (90%) Very frequent (99-80%) HP:0000989
2 cellulitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100658
3 edema 59 32 frequent (33%) Frequent (79-30%) HP:0000969
4 eosinophilia 59 32 frequent (33%) Frequent (79-30%) HP:0001880
5 abnormal blistering of the skin 59 32 frequent (33%) Frequent (79-30%) HP:0008066
6 skin vesicle 59 32 frequent (33%) Frequent (79-30%) HP:0200037
7 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
8 arthralgia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002829
9 vasculitis 59 Excluded (0%)

GenomeRNAi Phenotypes related to Wells Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.72 NLRP3 TNFRSF1A CXCL8 IL1B IL2 IL2RA
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.72 NLRP3 TNFRSF1A TP63 CXCL8 IL1B IL2

MGI Mouse Phenotypes related to Wells Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 MEFV NLRP3 RACK1 TNFRSF1A TP63 CRP
2 growth/size/body region MP:0005378 10.14 MEFV NLRP3 RACK1 TNFRSF1A TP63 FGFR2
3 immune system MP:0005387 10.06 CRP FGFR2 IL1B IL1R1 IL2 IL2RA
4 digestive/alimentary MP:0005381 9.98 TP63 FGFR2 IL2 IL2RA IL5 NLRP3
5 integument MP:0010771 9.86 FGFR2 IL1B IL1R1 MEFV NLRP3 RACK1
6 liver/biliary system MP:0005370 9.7 TNFRSF1A FGFR2 IL1R1 IL2 IL5 MEFV
7 neoplasm MP:0002006 9.5 FGFR2 IL1B IL1R1 IL2 IL5 TNFRSF1A
8 respiratory system MP:0005388 9.17 FGFR2 IL1R1 IL2 IL2RA IL5 TNFRSF1A

Drugs & Therapeutics for Wells Syndrome

Drugs for Wells Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 3
2 Antibodies Phase 3,Phase 2
3 Immunoglobulins Phase 3,Phase 2
4 Antibodies, Monoclonal Phase 3,Phase 2
5 Interleukin 1 Receptor Antagonist Protein Phase 2

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Efficacy, Safety, and Tolerability of ACZ885 in Patients With Muckle-Wells Syndrome Completed NCT00465985 Phase 3 ACZ885;Placebo
2 Efficacy and Safety of ACZ885 in Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease Completed NCT00685373 Phase 3 Canakinumab (ACZ885)
3 Efficacy and Safety Study of Canakinumab Administered for 6 Months (24 Weeks) in Japanese Patients With Cryopyrin-associated Periodic Syndromes Followed by an Extension Phase Completed NCT00991146 Phase 3 canakinumab
4 Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease Completed NCT01576367 Phase 3
5 Efficacy, Safety and Tolerability of ACZ885 in Pediatric Patients With the Following Cryopyrin-associated Periodic Syndromes: Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, or Neonatal Onset Multisystem Inflammatory Disease Completed NCT01302860 Phase 3 ACZ885
6 Rilonacept for Treatment of Cryopyrin-Associated Periodic Syndromes (CAPS) Completed NCT00288704 Phase 3 rilonacept 160 mg;Placebo;rilonacept 160 mg
7 The Safety and Efficacy of Canakinumab in Patients Aged 4 Years or Older Diagnosed With Cryopyrin-associated Periodic Syndromes (CAPS) in Canada Completed NCT01105507 Phase 3 canakinumab (company code: ACZ885D)
8 A Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 Studies Active, not recruiting NCT02334748 Phase 3 canakinumab
9 Safety and Tolerability of Rilonacept in Muckle-Wells Syndrome (MWS) or Schnitzler Syndrome (SchS) Completed NCT01045772 Phase 2 rilonacept
10 Interleukin-1 Trap to Treat Autoinflammatory Diseases Completed NCT00094900 Phase 2 IL-1 Trap
11 Safety, Efficacy, Pharmacokinetics, Pharmacodynamics of ACZ885 in Patients With NALP3 Mutations and Clinical Symptoms Completed NCT00487708 Phase 2 canakinumab
12 HL2351 CAPS Phase II Study Terminated NCT02853084 Phase 2 HL2351
13 A Pilot Study of XOMA 052 in Familial Cold Autoinflammatory Syndrome / Muckle-Wells Syndrome and Behcet's Disease Withdrawn NCT01211977 Phase 1, Phase 2 XOMA 052
14 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
15 Clinical Outcomes and Safety: A Registry Study of Ilaris (Canakinumab) Patients Completed NCT01213641

Search NIH Clinical Center for Wells Syndrome

Genetic Tests for Wells Syndrome

Anatomical Context for Wells Syndrome

MalaCards organs/tissues related to Wells Syndrome:

41
Testes, Skin, Monocytes, T Cells, B Cells, Neutrophil, Myeloid

Publications for Wells Syndrome

Articles related to Wells Syndrome:

(show top 50) (show all 224)
# Title Authors Year
1
<i>De novo ATP1A3</i> and compound heterozygous <i>NLRP3</i> mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome. ( 29922587 )
2018
2
Wells' Syndrome Associated with Coxsackievirus A6 Infection. ( 29972218 )
2018
3
Wells syndrome: a case of successful treatment with omalizumab. ( 29707773 )
2018
4
Wells syndrome (eosinophilic cellulitis) caused by adrenal insufficiency and relieved by cortisone supplementation. ( 29398098 )
2018
5
Eosinophilic infiltrate resembling eosinophilic cellulitis (Wells syndrome) in a patient with mycosis fungoides. ( 29469767 )
2018
6
Wells' syndrome-like reaction following Argas reflexus bites. ( 29400289 )
2018
7
Expanding the genetic profile of Hay-Wells syndrome. ( 29329681 )
2018
8
Eosinophilic cellulitis (Wells syndrome) successfully treated with mepolizumab. ( 29892672 )
2018
9
Resolution of unilateral sensorineural hearing loss in a pediatric patient with a severe phenotype of Muckle-Wells syndrome treated with Anakinra: a case report and review of the literature. ( 29382382 )
2018
10
Wells syndrome associated with lung cancer. ( 28951508 )
2017
11
Muckle-Wells syndrome: clinical perspectives. ( 28744167 )
2017
12
A Novel Mutation in the Pyrin Domain of the NOD-like Receptor Family Pyrin Domain Containing Protein 3 in Muckle-Wells Syndrome. ( 28229991 )
2017
13
Wells Syndrome with Bullous Lesions. ( 28351790 )
2017
14
Bullous Pesentation of Idiopathic Wells Syndrome (Eosinophilic Cellulitis). ( 28920134 )
2017
15
Muckle-Wells syndrome in the setting of basal cell nevus syndrome. ( 28686751 )
2017
16
Wells syndrome secondary to influenza vaccination: A case report and review of the literature. ( 29240526 )
2017
17
Periodic fever: From Still's disease to Muckle-Wells syndrome. ( 28583784 )
2017
18
A Case of Amyloidosis Caused by Sporadic Muckle-Wells Syndrome: Response to Treatment With Anakinra. ( 29239931 )
2017
19
Placental Transfer of Canakinumab in a Patient with Muckle-Wells Syndrome. ( 28386702 )
2017
20
Wells' Syndrome Successfully Treated with Colchicine. ( 28868003 )
2017
21
Endometriosis in the setting of Muckle-Wells syndrome treated with an IL-1I^ antagonist. ( 28508753 )
2017
22
A rare form of ankyloblepharon filiforme adnatum associated with the Hay-Wells syndrome and a c.1709T&amp;gt;C mutation on the TP63 gene. ( 29140732 )
2017
23
Wells' syndrome with a clinicopathological correlation associated with mantle-cell lymphoma. ( 26999270 )
2016
24
Muckle-Wells Syndrome: A Case Report with an NLRP3 T348M Mutation. ( 27435956 )
2016
25
Wells syndrome. ( 27767278 )
2016
26
Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review. ( 27357601 )
2016
27
Muckle-Wells syndrome in Chinese patients: a single center case series. ( 28028683 )
2016
28
Budget Impact Analysis of Canacinumab In The Treatment of Patients With Muckle-Wells Syndrome In The Russian Federation. ( 26533715 )
2015
29
Early detection of sensorineural hearing loss in Muckle-Wells-syndrome. ( 26531310 )
2015
30
Wells' Syndrome Mimicking Facial Cellulitis: A Report of Two Cases. ( 26120307 )
2015
31
Muckle-Wells syndrome in an Indian family associated with NLRP3 mutation. ( 25766347 )
2015
32
Influenza Vaccination as a Novel Trigger of Wells Syndrome in a Child. ( 25894853 )
2015
33
Muckle-Wells syndrome: a rare hereditary cryopyrin-associated periodic syndrome. ( 26218404 )
2015
34
Idiopathic Hypereosinophilic Syndrome With Cutaneous Manifestations and Flame Figures: A Spectrum of Eosinophilic Dermatoses Whose Features Overlap With Wells' Syndrome. ( 25839890 )
2015
35
Wells syndrome associated with chronic lymphocytic leukemia. ( 26375230 )
2015
36
Recurrent paraneoplastic wells syndrome in a patient with metastatic renal cell cancer. ( 24945651 )
2014
37
Eosinophilic leukocytoclastic vasculitis - a spectrum ranging from Wells' syndrome to Churg-Strauss syndrome? ( 25115356 )
2014
38
Renal involvement in secondary amyloidosis of Muckle-Wells syndrome: marked improvement of renal function and reduction of proteinuria after therapy with human anti-interleukin-1I^ monoclonal antibody canakinumab. ( 24510061 )
2014
39
Life of Lesions in Eosinophilic Cellulitis (Wells' Syndrome)-A Condition That May Be Missed at First Sight. ( 25238447 )
2014
40
Muckle wells syndrome associated with multifocal clinically isolated syndrome. ( 24618190 )
2014
41
Wells syndrome. ( 24505587 )
2014
42
Eosinophilic cellulitis (Wells' syndrome) caused by a temporary henna tattoo. ( 25395929 )
2014
43
Wells syndrome: response to dapsone therapy. ( 25143695 )
2014
44
Syndrome in question. Hay-Wells syndrome. ( 24770526 )
2014
45
IgG4-related disease of the paratestis in a patient with Wells syndrome: a case report. ( 25487870 )
2014
46
Wells syndrome (eosinophilic cellulitis): Proposed diagnostic criteria and a literature review of the drug-induced variant. ( 24421864 )
2013
47
Hearing loss in Muckle-Wells syndrome. ( 23440695 )
2013
48
Persistent hypereosinophilia with Wells syndrome. ( 22607377 )
2013
49
Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes. ( 24326009 )
2013
50
Gigantic erythematous plaques with violaceous oedematous borders: a quiz. Wells' syndrome. ( 23572063 )
2013

Variations for Wells Syndrome

Expression for Wells Syndrome

Search GEO for disease gene expression data for Wells Syndrome.

Pathways for Wells Syndrome

Pathways related to Wells Syndrome according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CRP CXCL8 FGFR2 IL1B IL1R1 IL2
2
Show member pathways
13.79 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
3
Show member pathways
13.61 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
4
Show member pathways
13.45 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
5
Show member pathways
13.35 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
6
Show member pathways
13.28 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
7
Show member pathways
13.16 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
8
Show member pathways
12.96 CXCL8 IL1B IL2 MEFV NLRP3 TNFRSF1A
9 12.77 CXCL8 FGFR2 IL2 IL2RA IL5
10
Show member pathways
12.74 IL1B IL1R1 IL2 IL2RA TNFRSF1A
11
Show member pathways
12.74 CXCL8 IL1B IL2 IL2RA IL5 RNASE3
12
Show member pathways
12.65 FGFR2 IL1B IL1R1 IL2 TNFRSF1A
13
Show member pathways
12.6 CXCL8 IL1B IL2 IL2RA NLRP3 RACK1
14
Show member pathways
12.59 CXCL8 IL1B IL2 IL2RA IL5
15 12.49 IL1B IL2 IL2RA TNFRSF1A
16
Show member pathways
12.38 IL1B IL1R1 IL2 IL2RA IL5
17 12.36 IL1R1 IL2 IL2RA TNFRSF1A
18
Show member pathways
12.16 FGFR2 IL1B IL1R1 IL2 IL2RA IL5
19 11.97 CXCL8 IL1B IL1R1 IL2
20
Show member pathways
11.93 IL1B IL1R1 IL2 IL2RA
21 11.92 IL2 IL2RA IL5
22
Show member pathways
11.88 HNRNPAB IL2 IL2RA
23 11.82 CXCL8 IL1B IL1R1
24 11.81 IL1B IL1R1 IL2RA IL5
25
Show member pathways
11.81 IL1B IL1R1 IL2 IL2RA IL5
26 11.79 CXCL8 IL1B IL1R1 TNFRSF1A
27 11.74 CXCL8 IL2 IL5
28 11.7 CXCL8 IL1B NLRP3
29
Show member pathways
11.66 CXCL8 IL2 IL2RA IL5
30 11.61 CXCL8 IL1B IL5
31
Show member pathways
11.53 CXCL8 IL1B IL2 TNFRSF1A
32 11.46 IL2 IL2RA IL5
33 11.41 IL1B MEFV NLRP3
34 11.4 CXCL8 IL1B IL1R1 TNFRSF1A
35 11.26 IL1B IL1R1 IL2 IL2RA IL5
36 11.24 IL1B IL2 IL5
37
Show member pathways
11.24 CXCL8 FGFR2 IL1B IL1R1 IL2 IL2RA
38 11.12 IL1B IL1R1 NLRP3
39 10.98 IL2 IL2RA IL5 TNFRSF1A
40 10.96 CRP CXCL8

GO Terms for Wells Syndrome

Cellular components related to Wells Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.32 CRP CXCL8 FGFR2 IL1B IL1R1 IL2

Biological processes related to Wells Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.87 FGFR2 IL1B IL2RA NLRP3 RACK1 TNFRSF1A
2 response to lipopolysaccharide GO:0032496 9.8 CXCL8 FGFR2 IL1B TNFRSF1A
3 immune response GO:0006955 9.8 CXCL8 IL1B IL1R1 IL2 IL2RA IL5
4 MAPK cascade GO:0000165 9.77 FGFR2 IL1B IL2 IL2RA IL5
5 defense response to Gram-positive bacterium GO:0050830 9.75 CRP NLRP3 RNASE3
6 positive regulation of T cell proliferation GO:0042102 9.69 IL1B IL2 IL2RA
7 positive regulation of T cell differentiation GO:0045582 9.6 IL2 IL2RA
8 regulation of regulatory T cell differentiation GO:0045589 9.58 IL2 IL2RA
9 inflammatory response to antigenic stimulus GO:0002437 9.57 IL1B IL2RA
10 positive regulation of immunoglobulin secretion GO:0051024 9.56 IL2 IL5
11 inflammatory response GO:0006954 9.56 CRP CXCL8 IL1B IL2RA IL5 MEFV
12 interleukin-2-mediated signaling pathway GO:0038110 9.55 IL2 IL2RA
13 negative regulation of inflammatory response GO:0050728 9.55 IL2 IL2RA MEFV NLRP3 TNFRSF1A
14 positive regulation of ceramide biosynthetic process GO:2000304 9.54 RACK1 TNFRSF1A
15 regulation of establishment of endothelial barrier GO:1903140 9.52 IL1B TNFRSF1A
16 negative regulation of lymphocyte proliferation GO:0050672 9.48 IL2 IL2RA
17 interleukin-1 beta production GO:0032611 9.46 IL1B NLRP3
18 regulation of T cell homeostatic proliferation GO:0046013 9.43 IL2 IL2RA
19 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development GO:0060529 9.4 FGFR2 TP63
20 cytokine-mediated signaling pathway GO:0019221 9.23 CXCL8 IL1B IL1R1 IL1RAPL2 IL2 IL2RA
21 positive regulation of transcription by RNA polymerase II GO:0045944 10.07 FGFR2 IL1B IL2 NLRP3 TNFRSF1A TP63

Molecular functions related to Wells Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 CXCL8 IL1B IL2 IL5
2 interleukin-1 receptor activity GO:0004908 8.96 IL1R1 IL1RAPL2
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.92 FGFR2 IL2 IL2RA IL5

Sources for Wells Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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