MCID: WRN003
MIFTS: 45

Wernicke Encephalopathy

Categories: Metabolic diseases, Neuronal diseases

Aliases & Classifications for Wernicke Encephalopathy

MalaCards integrated aliases for Wernicke Encephalopathy:

Name: Wernicke Encephalopathy 12 37 55 44 15 73
Wernicke's Encephalopathy 12 76
Wernicke-Korsakoff Syndrome 73
Wernicke's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2384
ICD10 33 E51.2
MeSH 44 D014899
KEGG 37 H01565
UMLS 73 C0043121

Summaries for Wernicke Encephalopathy

Disease Ontology : 12 A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).

MalaCards based summary : Wernicke Encephalopathy, also known as wernicke's encephalopathy, is related to beriberi and cerebral beriberi, and has symptoms including ataxia and ophthalmoplegia. An important gene associated with Wernicke Encephalopathy is SLC1A3 (Solute Carrier Family 1 Member 3), and among its related pathways/superpathways are Vitamin digestion and absorption and Neuroscience. The drugs Thiamine and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and occipital lobe, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Wernicke encephalopathy (WE) also Wernicke\'s encephalopathy is the presence of neurological symptoms... more...

Related Diseases for Wernicke Encephalopathy

Diseases related to Wernicke Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 beriberi 30.8 SLC19A3 TKT
2 cerebral beriberi 11.6
3 wernicke-korsakoff syndrome 11.3
4 encephalopathy 10.9
5 dicarboxylic aminoaciduria 10.4 SLC1A2 SLC1A3
6 medulloepithelioma 10.1 GFAP INA
7 neuromyelitis optica 10.1 GFAP SLC1A2
8 gliomatosis cerebri 10.1 GFAP INA
9 lymphoma 10.1
10 pancreatitis 10.1
11 medullomyoblastoma 10.1 GFAP INA
12 creutzfeldt-jakob disease 10.0
13 acute pancreatitis 10.0
14 neuronal ceroid-lipofuscinoses 10.0 GFAP SLC1A3
15 gastric cancer 9.9
16 infantile liver failure syndrome 1 9.9
17 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
18 liver cirrhosis 9.9
19 morbid obesity 9.9
20 cerebritis 9.9
21 central pontine myelinolysis 9.9
22 neuropathy 9.9
23 toxic encephalopathy 9.9 GFAP SLC1A2
24 hepatocellular carcinoma 9.8
25 multiple sclerosis 9.8
26 scleroderma, familial progressive 9.8
27 lung cancer 9.8
28 neuroblastoma 9.8
29 pancreatic cancer 9.8
30 cyclic vomiting syndrome 9.8
31 anorexia nervosa 9.8
32 diabetes mellitus, ketosis-prone 9.8
33 acute liver failure 9.8
34 crohn's disease 9.8
35 leukemia 9.8
36 abdominal tuberculosis 9.8
37 sensorineural hearing loss 9.8
38 polyneuropathy 9.8
39 optic nerve disease 9.8
40 retinitis 9.8
41 peripheral nervous system disease 9.8
42 leber hereditary optic neuropathy 9.8
43 t-cell leukemia 9.8
44 neuronitis 9.8
45 pellagra 9.8
46 duodenitis 9.8
47 encephalitis 9.8
48 hhv-6 encephalitis 9.8
49 tremor 9.8
50 hepatic encephalopathy 9.7 GLUL SLC1A2

Graphical network of the top 20 diseases related to Wernicke Encephalopathy:



Diseases related to Wernicke Encephalopathy

Symptoms & Phenotypes for Wernicke Encephalopathy

UMLS symptoms related to Wernicke Encephalopathy:


ataxia, ophthalmoplegia

MGI Mouse Phenotypes related to Wernicke Encephalopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 SLC1A3 TKT GFAP GLUL MAPT SLC19A3
2 growth/size/body region MP:0005378 9.73 SLC1A2 TKT GFAP GLUL MAPT SLC19A3
3 mortality/aging MP:0010768 9.7 SLC1A3 TKT GFAP GLUL MAPT SLC19A3
4 nervous system MP:0003631 9.5 SLC1A3 TKT GFAP GLUL INA MAPT
5 normal MP:0002873 9.02 SLC1A2 GFAP GLUL INA MAPT

Drugs & Therapeutics for Wernicke Encephalopathy

Drugs for Wernicke Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 3,Not Applicable 59-43-8, 70-16-6 1130
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-30-3 6037
3 Vitamins Phase 4,Phase 3,Not Applicable
4 Micronutrients Phase 4,Phase 3
5 Trace Elements Phase 4,Phase 3
6 Vitamin B Complex Phase 4,Phase 3
7 Thiamin Nutraceutical Phase 4,Phase 3,Not Applicable
8 Folate Nutraceutical Phase 4,Phase 3
9 Vitamin B9 Nutraceutical Phase 4,Phase 3
10
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
11
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
12
Promethazine Approved, Investigational Phase 3 60-87-7 4927
13 Gastrointestinal Agents Phase 3
14 Peripheral Nervous System Agents Phase 3
15 Anesthetics Phase 3
16 Anesthetics, Local Phase 3
17 Anti-Allergic Agents Phase 3
18 Antiemetics Phase 3
19 Antipruritics Phase 3
20 Autonomic Agents Phase 3
21 Central Nervous System Depressants Phase 3
22 Dermatologic Agents Phase 3
23 Histamine Antagonists Phase 3
24 Histamine H1 Antagonists Phase 3
25
Histamine Phosphate Phase 3 51-74-1 65513
26 Hypnotics and Sedatives Phase 3
27 Neurotransmitter Agents Phase 3
28
Etanercept Approved, Investigational 185243-69-0
29
Adalimumab Approved 331731-18-1 16219006
30 Analgesics
31 Analgesics, Non-Narcotic
32 Anti-Inflammatory Agents
33 Anti-Inflammatory Agents, Non-Steroidal
34 Antirheumatic Agents
35 Immunosuppressive Agents
36 pyruvate Nutraceutical Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4 Thiamine Hydrochloride
2 Alcohol: Thiamine and or Magnesium 1 Recruiting NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 Does Thiamine Help Vomiting and Nausea in Pregnancy? Terminated NCT00861523 Phase 3 thiamine & promethazine
4 Transcranial Magnetic Stimulation for "Voices" Completed NCT00308997 Phase 2
5 Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Recruiting NCT00567281 Phase 2
6 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207 Not Applicable
7 Study of the Effect of Transcranial Stimulations in Aphasic Subject Within a Year of Their Stroke Unknown status NCT02101398 Not Applicable
8 Models of Disordered Knowledge and Memory Systems in Dementia and Related Disorders Completed NCT00004557
9 A Study To Evaluate The Efficacy Of Enbrel (REGISTERED) Etanercept Over A Period Of 12 Months In The Routine Treatment Of Patients With Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis, Or Plaque Psoriasis. Completed NCT02486302 Etanercept
10 Safety and Effect on Quality of Life/Work Productivity of Humira in Patients With Rheumatoid Arthritis Completed NCT01076205
11 MRI and Diffusion Imaging of Eloquent Brain Areas to Optimize Brain Tumor Resection Planning Recruiting NCT01534104 Not Applicable
12 Modeling Treated Recovery From Aphasia Recruiting NCT03416738 Not Applicable
13 Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer Disease Active, not recruiting NCT03270137 Not Applicable
14 The Effect of tDCS on Subcortical Brain Functioning Enrolling by invitation NCT01602276 Not Applicable

Search NIH Clinical Center for Wernicke Encephalopathy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: wernicke encephalopathy

Genetic Tests for Wernicke Encephalopathy

Anatomical Context for Wernicke Encephalopathy

MalaCards organs/tissues related to Wernicke Encephalopathy:

41
Brain, Liver, Occipital Lobe, Lung, T Cells

Publications for Wernicke Encephalopathy

Articles related to Wernicke Encephalopathy:

(show top 50) (show all 194)
# Title Authors Year
1
A Case of Wernicke Encephalopathy Developing After Ileal Bypass Surgery. ( 29596284 )
2018
2
Wernicke Encephalopathy Following Laparoscopic Sleeve Gastrectomy-a Call to Evaluate Thiamine Deficiencies After Restrictive Bariatric Procedures. ( 29307105 )
2018
3
Preventing Wernicke Encephalopathy After Bariatric Surgery. ( 29693218 )
2018
4
Wernicke encephalopathy without delirium that appeared as agitation in a patient with lung cancer. ( 29747720 )
2018
5
Convergence Spasm in Wernicke Encephalopathy. ( 29276567 )
2018
6
Wernicke encephalopathy: (MRI) picture worth a thousand words. ( 29868178 )
2018
7
Wernicke encephalopathy in a patient after liver transplantation: A case report. ( 29308003 )
2017
8
A rare complication of vomiting in pregnancy: Wernicke encephalopathy. ( 28456382 )
2017
9
Wernicke Encephalopathy ( 29261914 )
2017
10
A case report: Non-alcoholic Wernicke encephalopathy associated with polyneuropathy. ( 28367669 )
2017
11
Differences Between Alcoholic and Nonalcoholic Patients With Wernicke Encephalopathy: A Multicenter Observational Study. ( 28578781 )
2017
12
Malnutrition in the elderly and Wernicke encephalopathy. ( 28363380 )
2017
13
Hypomagnesaemia as a trigger of relapsing non-alcoholic Wernicke encephalopathy: a case report. ( 28730572 )
2017
14
Wernicke Encephalopathy in a Patient with Pulmonary and Abdominal Tuberculosis. ( 29133769 )
2017
15
Wernicke encephalopathy without delirium in patients with cancer. ( 28464962 )
2017
16
Optic Chiasm Involvement With Concurrent Typical Wernicke Encephalopathy Magnetic Resonance Findings: A Case Report. ( 29029866 )
2017
17
More than a Case Report? Should Wernicke Encephalopathy After Sleeve Gastrectomy be a Concern? ( 28733807 )
2017
18
A patient with a 'typical presentation' of Wernicke encephalopathy was found to have sporadic Creutzfeldt-Jakob disease. ( 28653943 )
2017
19
Fundus Findings in Wernicke Encephalopathy. ( 28924437 )
2017
20
Hypothermia Presenting in Wernicke Encephalopathy: A Case Report. ( 28289649 )
2017
21
Challenges in Diagnosis and Treatment of Wernicke Encephalopathy: Report of 2 Cases. ( 26869612 )
2016
22
Wernicke encephalopathy and systemic sclerosis: rare association of rare conditions. ( 27590483 )
2016
23
Magnetic Resonance Imaging and H-proton Spectroscopy assessment of maternal and foetal brains in a case of pregnancy-associated Wernicke encephalopathy. ( 27624910 )
2016
24
Gayet-Wernicke encephalopathy: A rare and serious complication of gastrointestinal involvement in HIV infection. ( 27079166 )
2016
25
Wernicke encephalopathy: SWI detects petechial hemorrhages in mammillary bodies in vivo. ( 27799475 )
2016
26
Wernicke Encephalopathy after Restrictive Bariatric Surgery: A Significant Increase of a Rare Complication. ( 28234175 )
2016
27
Wernicke Encephalopathy in Adolescents After Bariatric Surgery: Case Report and Review. ( 27940680 )
2016
28
Early detection and successful treatment of Wernicke encephalopathy in a patient with advanced carcinoma of the external genitalia during chemotherapy. ( 26653343 )
2016
29
Cerebral salt-wasting syndrome in a child with Wernicke encephalopathy treated with fludrocortisone therapy: A case report. ( 27603336 )
2016
30
Non-alcoholic Wernicke Encephalopathy. ( 26787276 )
2016
31
Sleeve Gastrectomy and Wernicke Encephalopathy. ( 27415978 )
2016
32
Wernicke Encephalopathy after Restrictive Bariatric Surgery. ( 27097609 )
2016
33
Wernicke encephalopathy as initial presentation of lymphoma. ( 26805632 )
2016
34
Delayed diagnosis of Wernicke encephalopathy with irreversible neural damage after subtotal gastrectomy for gastric cancer: A case of medical liability? ( 27988455 )
2016
35
Cerebral vasospasm and wernicke encephalopathy secondary to adult cyclic vomiting syndrome: the role of magnesium. ( 27515947 )
2016
36
Nonalcoholic Wernicke Encephalopathy: An Entity Not to Be Missed! ( 27670213 )
2016
37
Wernicke encephalopathy in a patient with liver failure: Clinical case report. ( 27399058 )
2016
38
Complex ophthalmoplaegia denoting Wernicke encephalopathy in a non-alcoholic individual. ( 25828145 )
2015
39
Wernicke Encephalopathy. ( 26564935 )
2015
40
Wernicke encephalopathy and pellagra in an alcoholic and malnourished patient. ( 26490997 )
2015
41
Wernicke Encephalopathy and Sleeve Gastrectomy: A Case Report and Literature Review. ( 26539904 )
2015
42
Wernicke encephalopathy as rare complication of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. ( 26410803 )
2015
43
Iatrogenic Wernicke Encephalopathy in a Patient With Severe Hyperemesis Gravidarum. ( 25774927 )
2015
44
Wernicke Encephalopathy: a Future Problem Even After Sleeve Gastrectomy? A Systematic Literature Review. ( 26476834 )
2015
45
Diagnostic Clues to Human Herpesvirus 6 Encephalitis and Wernicke Encephalopathy After Pediatric Hematopoietic Cell Transplantation. ( 25564483 )
2015
46
Wernicke encephalopathy in a patient with severe acute pancreatitis. ( 26118580 )
2015
47
Wernicke Encephalopathy: A "Complication" of Acute Liver Failure. ( 26538061 )
2015
48
Putamina involvement in Wernicke encephalopathy induced by Janus Kinase 2 inhibitor. ( 25970282 )
2015
49
A Therapeutic Fast for Lymphoma Resulting in Wernicke Encephalopathy. ( 26104844 )
2015
50
Stem Cell Transplant-Associated Wernicke Encephalopathy in a Patient with High-Risk Neuroblastoma. ( 26174546 )
2015

Variations for Wernicke Encephalopathy

Expression for Wernicke Encephalopathy

Search GEO for disease gene expression data for Wernicke Encephalopathy.

Pathways for Wernicke Encephalopathy

Pathways related to Wernicke Encephalopathy according to KEGG:

37
# Name Kegg Source Accession
1 Vitamin digestion and absorption hsa04977

Pathways related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 GFAP MAPT SLC1A2 SLC1A3
2 11.05 GFAP SLC1A3
3
Show member pathways
9.7 GLUL SLC1A2 SLC1A3

GO Terms for Wernicke Encephalopathy

Cellular components related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.67 GFAP GLUL MAPT SLC1A3
2 neuron projection GO:0043005 9.63 GLUL MAPT SLC1A3
3 cytoplasmic ribonucleoprotein granule GO:0036464 9.43 INA MAPT
4 intermediate filament cytoskeleton GO:0045111 9.4 GFAP INA
5 cell body GO:0044297 9.33 GFAP GLUL MAPT
6 axolemma GO:0030673 9.32 MAPT SLC1A2
7 neurofilament GO:0005883 9.26 GFAP INA
8 glial cell projection GO:0097386 8.96 GFAP GLUL
9 myelin sheath GO:0043209 8.92 GFAP GLUL INA TKT

Biological processes related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transport GO:0006865 9.48 SLC1A2 SLC1A3
2 response to light stimulus GO:0009416 9.46 SLC1A2 SLC1A3
3 glutamate secretion GO:0014047 9.43 SLC1A2 SLC1A3
4 response to wounding GO:0009611 9.43 GFAP SLC1A2 SLC1A3
5 L-glutamate transmembrane transport GO:0015813 9.4 SLC1A2 SLC1A3
6 glutamate metabolic process GO:0006536 9.37 GLUL SLC1A3
7 axon development GO:0061564 9.32 GFAP MAPT
8 neurotransmitter uptake GO:0001504 9.16 GLUL SLC1A3
9 L-glutamate import across plasma membrane GO:0098712 8.96 SLC1A2 SLC1A3
10 D-aspartate import across plasma membrane GO:0070779 8.62 SLC1A2 SLC1A3

Molecular functions related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transmembrane transporter activity GO:0015171 9.32 SLC1A2 SLC1A3
2 L-glutamate transmembrane transporter activity GO:0005313 9.26 SLC1A2 SLC1A3
3 glutamate binding GO:0016595 9.16 GLUL SLC1A3
4 high-affinity glutamate transmembrane transporter activity GO:0005314 8.96 SLC1A2 SLC1A3
5 glutamate:sodium symporter activity GO:0015501 8.62 SLC1A2 SLC1A3

Sources for Wernicke Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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