MCID: WRN003
MIFTS: 47

Wernicke Encephalopathy

Categories: Metabolic diseases, Neuronal diseases

Aliases & Classifications for Wernicke Encephalopathy

MalaCards integrated aliases for Wernicke Encephalopathy:

Name: Wernicke Encephalopathy 12 36 54 43 15 17 71 32
Wernicke's Encephalopathy 12 74
Wernicke-Korsakoff Syndrome 71
Wernicke's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2384
KEGG 36 H01565
MeSH 43 D014899
SNOMED-CT 67 21007002
ICD10 32 E51.2
UMLS 71 C0043121 C0349464

Summaries for Wernicke Encephalopathy

KEGG : 36 Wernicke encephalopathy is a rare but serious neurological pathology due to a vitamin B1 deficiency. It is commonly associated with heavy alcohol consumption. Other clinical associations are with hyperemesis gravidarum, starvation, and prolonged intravenous feeding. Most patients present with the triad of ophthalmoplegia, ataxia, and confusion. It can be associated with life-threatening complication like central pontine myelinolysis. When Wernicke encephalopathy is suspected, treatment with high-dose parenteral thiamine (vitamin B1) should be given. If it is not treated promptly or if treatment is inadequate it can lead to death or to the chronic memory disorder, Korsakoff syndrome. Recent studies have suggested that an association exists between Wernicke encephalopathy and genetic polymorphisms in the thiamine transporter (SLC19A2).

MalaCards based summary : Wernicke Encephalopathy, also known as wernicke's encephalopathy, is related to wernicke-korsakoff syndrome and hepatic encephalopathy, and has symptoms including ataxia and ophthalmoplegia. An important gene associated with Wernicke Encephalopathy is TKT (Transketolase), and among its related pathways/superpathways are Vitamin digestion and absorption and Metabolism of water-soluble vitamins and cofactors. The drugs Magnesium Sulfate and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and bone, and related phenotypes are behavior/neurological and growth/size/body region

Disease Ontology : 12 A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).

Wikipedia : 74 Wernicke encephalopathy (WE), also Wernicke's encephalopathy is the presence of neurological symptoms... more...

Related Diseases for Wernicke Encephalopathy

Diseases related to Wernicke Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 320)
# Related Disease Score Top Affiliating Genes
1 wernicke-korsakoff syndrome 30.7 TPK1 TKT THTPA SLC19A3 SLC19A2 OGDH
2 hepatic encephalopathy 30.3 TSPO SLC1A2 GLUL
3 brain edema 30.2 SLC1A2 GLUL GFAP
4 status epilepticus 30.2 TSPO SLC1A2 GFAP
5 toxic encephalopathy 30.0 SLC1A3 SLC1A2 MAPT GFAP
6 aceruloplasminemia 29.9 SLC1A3 MAPT GLUL GFAP
7 alcoholic neuropathy 29.8 TKT THTPA
8 schizophrenia 29.2 TSPO SLC1A3 SLC1A2 MAPT GLUL GFAP
9 beriberi 29.0 TSPO TPK1 TKT THTPA SLC19A3 SLC19A2
10 cerebral beriberi 11.9
11 korsakoff's amnesic syndrome 11.5
12 encephalopathy 11.2
13 ataxia and polyneuropathy, adult-onset 10.8
14 pathologic nystagmus 10.6
15 alcohol dependence 10.6
16 kearns-sayre syndrome 10.6
17 subacute delirium 10.5
18 alcohol use disorder 10.5
19 leptin deficiency or dysfunction 10.4
20 ocular motor apraxia 10.4
21 human immunodeficiency virus type 1 10.3
22 medullomyoblastoma 10.3 INA GFAP
23 creutzfeldt-jakob disease 10.3
24 body mass index quantitative trait locus 11 10.3
25 body mass index quantitative trait locus 9 10.3
26 body mass index quantitative trait locus 8 10.3
27 body mass index quantitative trait locus 4 10.3
28 body mass index quantitative trait locus 10 10.3
29 body mass index quantitative trait locus 7 10.3
30 body mass index quantitative trait locus 12 10.3
31 body mass index quantitative trait locus 14 10.3
32 body mass index quantitative trait locus 18 10.3
33 body mass index quantitative trait locus 19 10.3
34 body mass index quantitative trait locus 20 10.3
35 amnestic disorder 10.3
36 acute pancreatitis 10.3
37 pancreatitis 10.3
38 neuropathy 10.3
39 lymphocytic leukemia 10.3
40 binswanger's disease 10.3 MAPT GFAP
41 yemenite deaf-blind hypopigmentation syndrome 10.3
42 leukemia, acute lymphoblastic 10.3
43 metabolic acidosis 10.3
44 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
45 polyneuropathy 10.3
46 peripheral nervous system disease 10.3
47 central pontine myelinolysis 10.3
48 myoclonus 10.3
49 tremor 10.3
50 autism 10.2

Graphical network of the top 20 diseases related to Wernicke Encephalopathy:



Diseases related to Wernicke Encephalopathy

Symptoms & Phenotypes for Wernicke Encephalopathy

UMLS symptoms related to Wernicke Encephalopathy:


ataxia, ophthalmoplegia

MGI Mouse Phenotypes related to Wernicke Encephalopathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 GAD1 GFAP GLUL JAK2 MAPT OGDH
2 growth/size/body region MP:0005378 10.1 GAD1 GFAP GLUL JAK2 KDM4C MAPT
3 cellular MP:0005384 10.07 GAD1 GFAP GLUL JAK2 KDM4C MAPT
4 homeostasis/metabolism MP:0005376 10 GAD1 GFAP GLUL JAK2 KDM4C MAPT
5 mortality/aging MP:0010768 10 GAD1 GFAP GLUL JAK2 KDM4C MAPT
6 nervous system MP:0003631 9.7 GAD1 GFAP GLUL INA MAPT SLC19A2
7 normal MP:0002873 9.28 GAD1 GFAP GLUL INA JAK2 MAPT

Drugs & Therapeutics for Wernicke Encephalopathy

Drugs for Wernicke Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
2
Ethanol Approved Phase 3 64-17-5 702
3
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
4
Histamine Approved, Investigational Phase 3 51-45-6 774
5
Promethazine Approved, Investigational Phase 3 60-87-7 4927
6
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
7
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
8
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 3 70-16-6, 59-43-8 1130
9 Analgesics Phase 2, Phase 3
10 Tocolytic Agents Phase 2, Phase 3
11 Anti-Arrhythmia Agents Phase 2, Phase 3
12 Anticonvulsants Phase 2, Phase 3
13 calcium channel blockers Phase 2, Phase 3
14 Calcium, Dietary Phase 2, Phase 3
15 Hormones Phase 2, Phase 3
16 Vitamins Phase 3
17 Trace Elements Phase 3
18 Vitamin B Complex Phase 3
19 Micronutrients Phase 3
20 Nutrients Phase 3
21 Anesthetics Phase 3
22 Vitamin B9 Phase 3
23 Folate Phase 3
24 Thiamin Phase 3
25 Central Nervous System Depressants Phase 3
26 Anesthetics, Local Phase 3
27 Antiemetics Phase 3
28 Gastrointestinal Agents Phase 3
29 Neurotransmitter Agents Phase 3
30 Hypnotics and Sedatives Phase 3
31 Dermatologic Agents Phase 3
32 Histamine H1 Antagonists Phase 3
33
Histamine Phosphate Phase 3 51-74-1 65513
34 Histamine Antagonists Phase 3
35 Antipruritics Phase 3
36 Autonomic Agents Phase 3
37 Anti-Allergic Agents Phase 3
38
Dopamine Approved 51-61-6, 62-31-7 681
39
Hydrocortisone acetate Approved, Vet_approved 50-03-3
40
Metoclopramide Approved, Investigational 364-62-5 4168
41
Hydrocortisone Approved, Vet_approved 50-23-7 5754
42 pyruvate
43 Emetics
44 Hydrocortisone hemisuccinate
45 Hydrocortisone-17-butyrate
46 Hydrocortisone 17-butyrate 21-propionate
47 Dopamine D2 Receptor Antagonists
48 Dopamine Agents
49 Dopamine Antagonists
50 Anti-Inflammatory Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpT In) for Treatment and Prevention of Wernicke-Korsakoff Syndrome (WKS): A Randomised Controlled Trial Completed NCT02788552 Phase 4 Thiamine Hydrochloride
2 A Prospective Randomised Controlled Trial of the Effect of Magnesium Sulphate Administration on Red Cell Transketolase Activity in Alcohol Dependent Patients at Risk of Wernicke Korsakoff Syndrome Treated With Thiamine Completed NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 Multicenter Randomized Placebo Controlled Trial Assessing the Efficacy of Oral Adjuvant Magnesium Supplementation in the Treatment of Alcohol Withdrawal Syndrome Recruiting NCT03033823 Phase 3 Magnesium;Placebo Oral Tablet
4 Comparison Between the Treatment of Thiamine and Promethazine for Improving Vomiting and Nausea in Pregnancy Terminated NCT00861523 Phase 3 thiamine & promethazine
5 From Uncomplicated Alcoholism to Korsakoff's Syndrome: Clinical, Genetic, Neuropsychological and Brain Examinations Unknown status NCT01455207
6 Efficacy of Thiamine Supplement for Improve Cardiovascular Function in Patients With Severe Hyperthyroidism Completed NCT02767245 Thiamine
7 Randomized Controlled Trial of Day Care Versus Inpatient Management of Nausea and Vomiting of Pregnancy Completed NCT00795561
8 Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study Recruiting NCT03724136
9 Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients: A Prospective Randomized Study Recruiting NCT03649009 Thiamine;Hydrocortisone

Search NIH Clinical Center for Wernicke Encephalopathy

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Thiamine hydrochloride
Thiamine Mononitrate

Cochrane evidence based reviews: wernicke encephalopathy

Genetic Tests for Wernicke Encephalopathy

Anatomical Context for Wernicke Encephalopathy

MalaCards organs/tissues related to Wernicke Encephalopathy:

40
Brain, Liver, Bone, Myeloid, Bone Marrow, Heart, Lung

Publications for Wernicke Encephalopathy

Articles related to Wernicke Encephalopathy:

(show top 50) (show all 1388)
# Title Authors PMID Year
1
Quantitative autoradiography using selective radioligands for central and peripheral-type benzodiazepine receptors in experimental Wernicke's encephalopathy: implications for positron emission tomography imaging. 54 61
8727262 1996
2
Cognitive impairment severity in relation to signs of subclinical Wernicke's encephalopathy in HIV and alcoholism comorbidity. 61
31725430 2020
3
Eye movements in demyelinating, autoimmune and metabolic disorders. 61
31770124 2020
4
Brain 18FDG-PET pattern in patients with alcohol-related cognitive impairment. 61
31428832 2020
5
Focal hyperemia in Wernicke's encephalopathy: a preliminary arterial spin labeling MRI study. 61
31732755 2020
6
Incidence of Adverse Reactions to Parenteral Thiamine in the Treatment of Wernicke's Encephalopathy, and Recommendations. 61
31565743 2019
7
Stability of high-dose thiamine in parenteral nutrition for treatment of patients with Wernicke's encephalopathy. 61
31866128 2019
8
Atypical presentation of a forgotten disease: refractory hypotension in beriberi. 61
31285553 2019
9
CLINICAL PRACTICE GUIDELINES FOR THE PERIOPERATIVE NUTRITION, METABOLIC, AND NONSURGICAL SUPPORT OF PATIENTS UNDERGOING BARIATRIC PROCEDURES - 2019 UPDATE: COSPONSORED BY AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/AMERICAN COLLEGE OF ENDOCRINOLOGY, THE OBESITY SOCIETY, AMERICAN SOCIETY FOR METABOLIC & BARIATRIC SURGERY, OBESITY MEDICINE ASSOCIATION, AND AMERICAN SOCIETY OF ANESTHESIOLOGISTS - EXECUTIVE SUMMARY. 61
31682518 2019
10
Nonalcoholic Wernicke's Encephalopathy Followed by Neuromyelitis Optica Spectrum Disorders: A Case Report. 61
31857564 2019
11
Case of non-alcoholic Wernicke's encephalopathy. 61
31732541 2019
12
Wernicke encephalopathy associated with hyperemesis gravidarum. 61
31784394 2019
13
Wernicke's encephalopathy. 61
31735353 2019
14
Nonalcoholic Wernicke's encephalopathy: a retrospective study of 17 cases. 61
31502510 2019
15
Wernicke encephalopathy following gastrojejunostomy: A case report and review of the literature. 61
31687617 2019
16
Malnutrition in the elderly and Wernicke encephalopathy. 61
28363380 2019
17
A Case of Ascending Sensory Neuropathy Due to Acute Onset Thiamine Deficiency After Intragastric Balloon Placement. 61
31134479 2019
18
Functional neurological symptoms masquerading as Wernicke encephalopathy following bariatric surgery. 61
31656438 2019
19
Subclinical thiamine deficiency identified by preoperative evaluation in an ovarian cancer patient: Diagnosis and the need for preoperative thiamine measurement. 61
30168403 2019
20
Thiamine Deficiency in a Child with Short Bowel Syndrome and Review. 61
31555575 2019
21
Rapid same-day resolution of internuclear ophthalmoplegia in Wernicke encephalopathy following parenteral high dose thiamine. 61
31712022 2019
22
Hyperemesis gravidarum causing Wernicke-Korsakoff syndrome: A rare complication. 61
31215137 2019
23
[Thiamin and alcohol use disorder: A national survey of practice]. 61
31587815 2019
24
Vertical nystagmus in Wernicke's encephalopathy: pathogenesis and role of central processing of information from the otoliths. 61
31028542 2019
25
[Gayet-Wernicke's encephalopathy after bariatric surgery]. 61
31473023 2019
26
Nausea and vomiting of pregnancy and hyperemesis gravidarum. 61
31515515 2019
27
Vision Loss As a Presenting Feature of Wernicke Encephalopathy. 61
30829946 2019
28
Suspected dietary-related Wernicke's encephalopathy. 61
31447924 2019
29
Infantile Thiamine Deficiency: New Insights into an Old Disease. 61
31477649 2019
30
Posterior reversible encephalopathy syndrome and Wernicke encephalopathy in patient with acute graft-versus-host disease. 61
31193981 2019
31
Ataxia. 61
31356292 2019
32
A case of Wernicke's encephalopathy following complicated laparoscopic pylorus-preserving pancreaticoduodenectomy. 61
31501822 2019
33
Pathophysiological Evaluation in a Case of Wernicke's Encephalopathy by Multimodal MRI. 61
31512648 2019
34
Cognitive and Motor Impairment Severity Related to Signs of Subclinical Wernicke's Encephalopathy in HIV Infection. 61
30958387 2019
35
Alcohol Induced Wernicke Encephalopathy with Atypical MRI Findings. 61
31565609 2019
36
Refeeding Syndrome and Non-Alcoholic Wernicke's Encephalopathy in a Middle-aged Male Initially Presenting with Gallstone Pancreatitis: A Clinical Challenge. 61
31538039 2019
37
Recurrent Wernicke's encephalopathy in pregnancy: A case report. 61
29272216 2019
38
Heavy Cannabis Use Associated with Wernicke's Encephalopathy. 61
31523540 2019
39
FDG PET/MRI Findings Pointing Toward a Gayet-Wernicke Encephalopathy. 61
31058688 2019
40
Hypothalamic sydrome as an initial presentation of Wernicke encephalopathy: A case report. 61
31261554 2019
41
Wernicke's Encephalopathy Accompanying Acute Axonal Polyneuropathy: A Case Report. 61
31223251 2019
42
Wernicke Encephalopathy-Clinical Pearls. 61
31171116 2019
43
Wernicke-Korsakoff syndrome: Focus on low-threshold diagnosis and prompt treatment in the primary care setting. 61
30823858 2019
44
Wernicke's encephalopathy in hyperemesis gravidarum: A systematic review. 61
30889425 2019
45
Using clinical decision support through the electronic medical record to increase prescribing of high-dose parenteral thiamine in hospitalized patients with alcohol use disorder. 61
30797383 2019
46
Wernicke's encephalopathy as a presentation of severe thiamine deficiency after cardiac valve surgery: A case report and narrative review. 61
31565206 2019
47
Non-alcoholic Wernicke encephalopathy presenting as bilateral hearing loss: a case report. 61
30729314 2019
48
Wernicke encephalopathy hearing loss and palinacousis. 61
30957373 2019
49
Visual loss and optic neuropathy associated with Wernicke's encephalopathy in hyperemesis gravidarum. 61
31041282 2019
50
Pellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India. 61
30721993 2019

Variations for Wernicke Encephalopathy

Expression for Wernicke Encephalopathy

Search GEO for disease gene expression data for Wernicke Encephalopathy.

Pathways for Wernicke Encephalopathy

Pathways related to Wernicke Encephalopathy according to KEGG:

36
# Name Kegg Source Accession
1 Vitamin digestion and absorption hsa04977

GO Terms for Wernicke Encephalopathy

Cellular components related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axolemma GO:0030673 9.16 SLC1A2 MAPT
2 cell body GO:0044297 9.13 MAPT GLUL GFAP
3 glial cell projection GO:0097386 8.8 MAPT GLUL GFAP

Biological processes related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.83 TSPO SLC1A3 SLC1A2 GAD1
2 response to wounding GO:0009611 9.69 SLC1A3 SLC1A2 GFAP
3 positive regulation of glial cell proliferation GO:0060252 9.55 TSPO GFAP
4 L-glutamate transmembrane transport GO:0015813 9.54 SLC1A3 SLC1A2
5 neurotransmitter uptake GO:0001504 9.49 SLC1A3 GLUL
6 vitamin transport GO:0051180 9.48 SLC19A3 SLC19A2
7 L-glutamate import across plasma membrane GO:0098712 9.46 SLC1A3 SLC1A2
8 vitamin transmembrane transport GO:0035461 9.43 SLC19A3 SLC19A2
9 D-aspartate import across plasma membrane GO:0070779 9.4 SLC1A3 SLC1A2
10 thiamine metabolic process GO:0006772 9.37 TPK1 THTPA
11 glutamate catabolic process GO:0006538 9.32 GLUL GAD1
12 thiamine transmembrane transport GO:0071934 9.26 SLC19A3 SLC19A2
13 thiamine transport GO:0015888 9.16 SLC19A3 SLC19A2
14 gamma-aminobutyric acid biosynthetic process GO:0009449 8.96 SLC1A3 GAD1
15 thiamine-containing compound metabolic process GO:0042723 8.92 TPK1 THTPA SLC19A3 SLC19A2

Molecular functions related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 L-glutamate transmembrane transporter activity GO:0005313 9.37 SLC1A3 SLC1A2
2 vitamin transmembrane transporter activity GO:0090482 9.32 SLC19A3 SLC19A2
3 high-affinity glutamate transmembrane transporter activity GO:0005314 9.26 SLC1A3 SLC1A2
4 glutamate:sodium symporter activity GO:0015501 9.16 SLC1A3 SLC1A2
5 thiamine transmembrane transporter activity GO:0015234 8.96 SLC19A3 SLC19A2
6 glutamate binding GO:0016595 8.8 SLC1A3 GLUL GAD1

Sources for Wernicke Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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