MCID: WRN003
MIFTS: 49

Wernicke Encephalopathy

Categories: Metabolic diseases, Neuronal diseases

Aliases & Classifications for Wernicke Encephalopathy

MalaCards integrated aliases for Wernicke Encephalopathy:

Name: Wernicke Encephalopathy 12 38 56 45 15 17 74
Wernicke's Encephalopathy 12 77
Wernicke-Korsakoff Syndrome 74
Wernicke's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2384
KEGG 38 H01565
MeSH 45 D014899
SNOMED-CT 69 21007002
ICD10 34 E51.2

Summaries for Wernicke Encephalopathy

Disease Ontology : 12 A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).

MalaCards based summary : Wernicke Encephalopathy, also known as wernicke's encephalopathy, is related to beriberi and neuromyelitis optica, and has symptoms including ataxia and ophthalmoplegia. An important gene associated with Wernicke Encephalopathy is TKT (Transketolase), and among its related pathways/superpathways are Vitamin digestion and absorption and Neuroscience. The drugs Thiamine and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, thalamus and t cells, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 77 Wernicke encephalopathy (WE), also Wernicke''s encephalopathy is the presence of neurological symptoms... more...

Related Diseases for Wernicke Encephalopathy

Diseases related to Wernicke Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 beriberi 30.8 SLC19A3 TKT
2 neuromyelitis optica 29.9 GFAP SLC1A2
3 cerebral beriberi 11.8
4 korsakoff's amnesic syndrome 11.4
5 wernicke-korsakoff syndrome 11.2
6 encephalopathy 11.1
7 lymphocytic leukemia 10.3
8 schizophrenia 10.3
9 ocular motor apraxia 10.3
10 leukemia, acute lymphoblastic 10.3
11 creutzfeldt-jakob disease 10.3
12 lymphoma 10.3
13 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
14 acute pancreatitis 10.2
15 pancreatitis 10.2
16 autism 10.2
17 acute lymphocytic leukemia 10.2
18 hematopoietic stem cell transplantation 10.2
19 diarrhea 10.2
20 acquired immunodeficiency syndrome 10.2
21 dicarboxylic aminoaciduria 10.2 SLC1A2 SLC1A3
22 lung cancer 10.1
23 infantile liver failure syndrome 1 10.1
24 liver cirrhosis 10.1
25 morbid obesity 10.1
26 central pontine myelinolysis 10.1
27 neuropathy 10.1
28 systemic lupus erythematosus 10.1
29 yemenite deaf-blind hypopigmentation syndrome 10.1
30 alcohol abuse 10.1
31 metabolic acidosis 10.1
32 hyperthyroidism 10.1
33 lupus erythematosus 10.1
34 achalasia 10.1
35 seizure disorder 10.1
36 medulloepithelioma 10.0 GFAP INA
37 gliomatosis cerebri 10.0 GFAP INA
38 medullomyoblastoma 10.0 GFAP INA
39 neuronal ceroid-lipofuscinoses 10.0 GFAP SLC1A3
40 hepatocellular carcinoma 10.0
41 multiple sclerosis 10.0
42 scleroderma, familial progressive 10.0
43 neuroblastoma 10.0
44 pancreatic cancer 10.0
45 cyclic vomiting syndrome 10.0
46 anorexia nervosa 10.0
47 diabetes mellitus, ketosis-prone 10.0
48 gastric cancer 10.0
49 acute liver failure 10.0
50 crohn's disease 10.0

Graphical network of the top 20 diseases related to Wernicke Encephalopathy:



Diseases related to Wernicke Encephalopathy

Symptoms & Phenotypes for Wernicke Encephalopathy

UMLS symptoms related to Wernicke Encephalopathy:


ataxia, ophthalmoplegia

MGI Mouse Phenotypes related to Wernicke Encephalopathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 GFAP GLUL MAPT SLC19A3 SLC1A2 SLC1A3
2 growth/size/body region MP:0005378 9.73 GFAP GLUL MAPT SLC19A3 SLC1A2 TKT
3 mortality/aging MP:0010768 9.7 GFAP GLUL MAPT SLC19A3 SLC1A2 SLC1A3
4 nervous system MP:0003631 9.56 GFAP GLUL INA MAPT SLC19A3 SLC1A2
5 normal MP:0002873 9.02 GFAP GLUL INA MAPT SLC1A2

Drugs & Therapeutics for Wernicke Encephalopathy

Drugs for Wernicke Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 59-43-8, 70-16-6 1130
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
3 Vitamins Phase 4,Phase 2,Phase 3,Not Applicable
4 Thiamin Phase 4,Phase 2,Phase 3,Not Applicable
5 Nutrients Phase 4,Phase 2,Phase 3
6 Vitamin B Complex Phase 4,Phase 2,Phase 3
7 Trace Elements Phase 4,Phase 2,Phase 3
8 Micronutrients Phase 4,Phase 2,Phase 3
9 Vitamin B9 Phase 4,Phase 2,Phase 3
10 Folate Phase 4,Phase 2,Phase 3
11
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
12
Ethanol Approved Phase 2, Phase 3 64-17-5 702
13
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
14
Promethazine Approved, Investigational Phase 3 60-87-7 4927
15
Histamine Approved, Investigational Phase 3 51-45-6 774
16
Calcium Approved, Nutraceutical Phase 2, Phase 3 7440-70-2 271
17 Analgesics Phase 2, Phase 3
18 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
19 Gastrointestinal Agents Phase 3
20 Anticonvulsants Phase 2, Phase 3
21 Calcium, Dietary Phase 2, Phase 3
22 Anesthetics Phase 2, Phase 3,Phase 3
23 calcium channel blockers Phase 2, Phase 3
24 Anti-Arrhythmia Agents Phase 2, Phase 3
25 Hormones Phase 2, Phase 3
26 Central Nervous System Depressants Phase 2, Phase 3,Phase 3
27 Tocolytic Agents Phase 2, Phase 3
28 Anti-Allergic Agents Phase 3
29
Histamine Phosphate Phase 3 51-74-1 65513
30 Autonomic Agents Phase 3
31 Neurotransmitter Agents Phase 3
32 Histamine H1 Antagonists Phase 3
33 Anesthetics, Local Phase 3
34 Antiemetics Phase 3
35 Antipruritics Phase 3
36 Dermatologic Agents Phase 3
37 Histamine Antagonists Phase 3
38 Hypnotics and Sedatives Phase 3
39
Etanercept Approved, Investigational 185243-69-0
40
Tofacitinib Approved, Investigational 477600-75-2
41 pyruvate Not Applicable
42 Anti-Inflammatory Agents
43 Immunosuppressive Agents
44 Anti-Inflammatory Agents, Non-Steroidal
45 Immunologic Factors
46 Analgesics, Non-Narcotic
47 Antirheumatic Agents
48 Protein Kinase Inhibitors

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4 Thiamine Hydrochloride
2 Alcohol: Thiamine and or Magnesium 1 Recruiting NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 An Efficacy and Safety Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib Recruiting NCT03755518 Phase 3 FEDRATINIB
4 Does Thiamine Help Vomiting and Nausea in Pregnancy? Terminated NCT00861523 Phase 3 thiamine & promethazine
5 Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Unknown status NCT00567281 Phase 2
6 Transcranial Magnetic Stimulation for "Voices" Completed NCT00308997 Phase 2
7 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207 Not Applicable
8 Study of the Effect of Transcranial Stimulations in Aphasic Subject Within a Year of Their Stroke Unknown status NCT02101398 Not Applicable
9 Models of Disordered Knowledge and Memory Systems in Dementia and Related Disorders Completed NCT00004557
10 A Study To Evaluate The Efficacy Of Enbrel (REGISTERED) Etanercept Over A Period Of 12 Months In The Routine Treatment Of Patients With Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis, Or Plaque Psoriasis. Completed NCT02486302 Etanercept
11 MRI and Diffusion Imaging of Eloquent Brain Areas to Optimize Brain Tumor Resection Planning Recruiting NCT01534104 Not Applicable
12 Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study Recruiting NCT03724136 Not Applicable
13 Modeling Treated Recovery From Aphasia Recruiting NCT03416738 Not Applicable
14 Observational Study to Determine How Physicians Make Treatment Decisions in Patients Treated With Tofacitinib for Moderate to Severe Active Rheumatoid Arthritis Recruiting NCT03387423 Tofacitinib
15 Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer Disease Active, not recruiting NCT03270137 Not Applicable
16 The Effect of tDCS on Subcortical Brain Functioning Terminated NCT01602276 Not Applicable

Search NIH Clinical Center for Wernicke Encephalopathy

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: wernicke encephalopathy

Genetic Tests for Wernicke Encephalopathy

Anatomical Context for Wernicke Encephalopathy

MalaCards organs/tissues related to Wernicke Encephalopathy:

42
Brain, Thalamus, T Cells, Cerebellum, Bone, Bone Marrow, Cortex

Publications for Wernicke Encephalopathy

Articles related to Wernicke Encephalopathy:

(show top 50) (show all 674)
# Title Authors Year
1
Starvation-induced diplopia and weakness: a case of beriberi and Wernicke's encephalopathy. ( 30610031 )
2019
2
Dry Beriberi Due to Thiamine Deficiency Associated with Peripheral Neuropathy and Wernicke's Encephalopathy Mimicking Guillain-Barré syndrome: A Case Report and Review of the Literature. ( 30862772 )
2019
3
An autopsied case of MM1-type sporadic Creutzfeldt-Jakob disease with pathology of Wernicke encephalopathy. ( 30409087 )
2019
4
Vision Loss As a Presenting Feature of Wernicke Encephalopathy. ( 30829946 )
2019
5
Wernicke encephalopathy concurrent with polyradiculoneuropathy in a young man after bariatric surgery: A case report. ( 30855500 )
2019
6
Wernicke's encephalopathy in hyperemesis gravidarum: A systematic review. ( 30889425 )
2019
7
Non-alcoholic Wernicke encephalopathy presenting as bilateral hearing loss: a case report. ( 30729314 )
2019
8
Complete recovery in Wernicke's encephalopathy complicating hyperemesis gravidarum. ( 30737323 )
2019
9
A Case of Wernicke Encephalopathy Developing After Ileal Bypass Surgery. ( 29596284 )
2018
10
Wernicke Encephalopathy Following Laparoscopic Sleeve Gastrectomy-a Call to Evaluate Thiamine Deficiencies After Restrictive Bariatric Procedures. ( 29307105 )
2018
11
Preventing Wernicke Encephalopathy After Bariatric Surgery. ( 29693218 )
2018
12
Wernicke encephalopathy without delirium that appeared as agitation in a patient with lung cancer. ( 29747720 )
2018
13
Convergence Spasm in Wernicke Encephalopathy. ( 29276567 )
2018
14
Wernicke encephalopathy: (MRI) picture worth a thousand words. ( 29868178 )
2018
15
Wernicke's encephalopathy in a child with autism during chemotherapy for T-cell acute leukemia. ( 30160032 )
2018
16
Preventing Wernicke's encephalopathy in anorexia nervosa: A systematic review. ( 29984541 )
2018
17
Postseizure aphasia in Wernicke's encephalopathy: a case report and review of literature. ( 30349257 )
2018
18
Gastrointestinal beriberi: a forme fruste of Wernicke's encephalopathy? ( 29982183 )
2018
19
Wernicke's Encephalopathy due to Non-Alcoholic Gastrointestinal Tract Disease. ( 30622385 )
2018
20
Dracula teeth-like image on MRI of a patient with non alcoholic Wernicke encephalopathy. ( 30453205 )
2018
21
Wernicke's encephalopathy in a patient with non-Hodgkin's lymphoma post-Autologous HSCT. ( 30517233 )
2018
22
Wernicke Encephalopathy with Atypical Findings on Magnetic Resonance Imaging. ( 30532369 )
2018
23
Non-alcoholic Wernicke encephalopathy: great masquerader. ( 30593527 )
2018
24
Conversion of upbeat to downbeat nystagmus in Wernicke encephalopathy. ( 30348852 )
2018
25
Wernicke's Encephalopathy. ( 30364782 )
2018
26
Thiamine Prescribing and Wernicke's Encephalopathy Risk Factors in Patients With Alcohol Use Disorders at a Psychiatric Hospital. ( 30427818 )
2018
27
Optic Discs Swelling Procrastinates Wernicke's Encephalopathy Associated with Hyperemesis Gravidarum: A Case Report and Review of Literature. ( 30112269 )
2018
28
Progressive supranuclear palsy responding to intravenous thiamine: superimposed Wernicke's encephalopathy? ( 30131406 )
2018
29
Wernicke Encephalopathy Due to Hyperemesis Gravidarum in Pregnancy: A Case Report. ( 30237950 )
2018
30
Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. ( 30281514 )
2018
31
Wernicke's Encephalopathy as a Rare Complication of Hyperemesis Gravidarum: A Case Report and Review of Literature. ( 30013861 )
2018
32
Wernicke encephalopathy in a lung cancer patient during treatment with nivolumab. ( 30073944 )
2018
33
B Minus: Wernicke's Encephalopathy. ( 30102912 )
2018
34
Wernicke's encephalopathy after cardiac surgery. ( 29667898 )
2018
35
Case Report of Wernicke's Encephalopathy After Sleeve Gastrectomy. ( 29730896 )
2018
36
Early detection and successful treatment of Wernicke's encephalopathy in outpatients without the complete classic triad of symptoms who attended a psycho-oncology clinic. ( 29478423 )
2018
37
Ocular manifestations in a case of Wernicke's encephalopathy due to hyperemesis gravidarum. ( 29563707 )
2018
38
Vestibular Dysfunction in Wernicke's Encephalopathy: Predominant Impairment of the Horizontal Semicircular Canals. ( 29593640 )
2018
39
Wernicke's Encephalopathy 5 Years After a Whipple Procedure. ( 29623164 )
2018
40
Impairment of Thiamine Transport at the GUT-BBB-AXIS Contributes to Wernicke's Encephalopathy. ( 29128903 )
2018
41
Antecedent diffuse cerebellar lesions on diffusion-weighted MRI in nonalcoholic Wernicke's encephalopathy. ( 29143148 )
2018
42
Prolonged hypotension associated with Wernicke's encephalopathy. ( 28901332 )
2018
43
Wernicke's encephalopathy following reduced food intake due to depressive disorders. ( 28410563 )
2018
44
Wernicke encephalopathy in a patient after liver transplantation: A case report. ( 29308003 )
2017
45
A rare complication of vomiting in pregnancy: Wernicke encephalopathy. ( 28456382 )
2017
46
Wernicke Encephalopathy ( 29261914 )
2017
47
A case report: Non-alcoholic Wernicke encephalopathy associated with polyneuropathy. ( 28367669 )
2017
48
Differences Between Alcoholic and Nonalcoholic Patients With Wernicke Encephalopathy: A Multicenter Observational Study. ( 28578781 )
2017
49
Malnutrition in the elderly and Wernicke encephalopathy. ( 28363380 )
2017
50
Hypomagnesaemia as a trigger of relapsing non-alcoholic Wernicke encephalopathy: a case report. ( 28730572 )
2017

Variations for Wernicke Encephalopathy

Expression for Wernicke Encephalopathy

Search GEO for disease gene expression data for Wernicke Encephalopathy.

Pathways for Wernicke Encephalopathy

Pathways related to Wernicke Encephalopathy according to KEGG:

38
# Name Kegg Source Accession
1 Vitamin digestion and absorption hsa04977

Pathways related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 GFAP MAPT SLC1A2 SLC1A3
2 11.05 GFAP SLC1A3
3
Show member pathways
9.7 GLUL SLC1A2 SLC1A3

GO Terms for Wernicke Encephalopathy

Cellular components related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.67 GFAP GLUL MAPT SLC1A3
2 neuron projection GO:0043005 9.63 GLUL MAPT SLC1A3
3 cytoplasmic ribonucleoprotein granule GO:0036464 9.43 INA MAPT
4 intermediate filament cytoskeleton GO:0045111 9.4 GFAP INA
5 cell body GO:0044297 9.33 GFAP GLUL MAPT
6 axolemma GO:0030673 9.32 MAPT SLC1A2
7 neurofilament GO:0005883 9.26 GFAP INA
8 myelin sheath GO:0043209 9.26 GFAP GLUL INA TKT
9 glial cell projection GO:0097386 8.8 GFAP GLUL MAPT

Biological processes related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transport GO:0006865 9.48 SLC1A2 SLC1A3
2 response to light stimulus GO:0009416 9.46 SLC1A2 SLC1A3
3 glutamate metabolic process GO:0006536 9.43 GLUL SLC1A3
4 glutamate secretion GO:0014047 9.4 SLC1A2 SLC1A3
5 axon development GO:0061564 9.37 GFAP MAPT
6 L-glutamate transmembrane transport GO:0015813 9.32 SLC1A2 SLC1A3
7 neurotransmitter uptake GO:0001504 9.26 GLUL SLC1A3
8 L-glutamate import across plasma membrane GO:0098712 9.16 SLC1A2 SLC1A3
9 response to wounding GO:0009611 9.13 GFAP SLC1A2 SLC1A3
10 D-aspartate import across plasma membrane GO:0070779 8.62 SLC1A2 SLC1A3

Molecular functions related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transmembrane transporter activity GO:0015171 9.32 SLC1A2 SLC1A3
2 L-glutamate transmembrane transporter activity GO:0005313 9.26 SLC1A2 SLC1A3
3 glutamate binding GO:0016595 9.16 GLUL SLC1A3
4 high-affinity glutamate transmembrane transporter activity GO:0005314 8.96 SLC1A2 SLC1A3
5 glutamate:sodium symporter activity GO:0015501 8.62 SLC1A2 SLC1A3

Sources for Wernicke Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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