MCID: WRN003
MIFTS: 48

Wernicke Encephalopathy

Categories: Metabolic diseases, Neuronal diseases

Aliases & Classifications for Wernicke Encephalopathy

MalaCards integrated aliases for Wernicke Encephalopathy:

Name: Wernicke Encephalopathy 12 37 55 44 15 73
Wernicke's Encephalopathy 12 76
Wernicke-Korsakoff Syndrome 73
Wernicke's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2384
ICD10 33 E51.2
MeSH 44 D014899
SNOMED-CT 68 21007002
KEGG 37 H01565

Summaries for Wernicke Encephalopathy

Disease Ontology : 12 A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).

MalaCards based summary : Wernicke Encephalopathy, also known as wernicke's encephalopathy, is related to beriberi and cerebral beriberi, and has symptoms including ataxia and ophthalmoplegia. An important gene associated with Wernicke Encephalopathy is SLC1A3 (Solute Carrier Family 1 Member 3), and among its related pathways/superpathways are Vitamin digestion and absorption and Neuroscience. The drugs Thiamine and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 76 Wernicke encephalopathy (WE), also Wernicke''s encephalopathy is the presence of neurological symptoms... more...

Related Diseases for Wernicke Encephalopathy

Diseases related to Wernicke Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 beriberi 30.6 TKT SLC19A3
2 cerebral beriberi 11.8
3 wernicke-korsakoff syndrome 11.5
4 encephalopathy 11.1
5 creutzfeldt-jakob disease 10.2
6 lymphoma 10.2
7 acute pancreatitis 10.1
8 pancreatitis 10.1
9 dicarboxylic aminoaciduria 10.1 SLC1A3 SLC1A2
10 lung cancer 10.1
11 infantile liver failure syndrome 1 10.1
12 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
13 liver cirrhosis 10.1
14 morbid obesity 10.1
15 central pontine myelinolysis 10.1
16 neuropathy 10.1
17 medulloepithelioma 10.0 INA GFAP
18 gliomatosis cerebri 10.0 INA GFAP
19 neuromyelitis optica 10.0 SLC1A2 GFAP
20 medullomyoblastoma 10.0 INA GFAP
21 toxic encephalopathy 10.0 SLC1A2 GFAP
22 neuronal ceroid-lipofuscinoses 10.0 SLC1A3 GFAP
23 hepatic encephalopathy 9.9 SLC1A2 GLUL
24 hepatocellular carcinoma 9.9
25 multiple sclerosis 9.9
26 scleroderma, familial progressive 9.9
27 neuroblastoma 9.9
28 pancreatic cancer 9.9
29 graves disease 1 9.9
30 cyclic vomiting syndrome 9.9
31 anorexia nervosa 9.9
32 diabetes mellitus, ketosis-prone 9.9
33 gastric cancer 9.9
34 acute liver failure 9.9
35 crohn's disease 9.9
36 leukemia 9.9
37 abdominal tuberculosis 9.9
38 sensorineural hearing loss 9.9
39 polyneuropathy 9.9
40 optic nerve disease 9.9
41 human immunodeficiency virus infectious disease 9.9
42 peripheral nervous system disease 9.9
43 leber hereditary optic neuropathy 9.9
44 t-cell leukemia 9.9
45 pellagra 9.9
46 encephalitis 9.9
47 pathologic nystagmus 9.9
48 degos 'en cocarde' erythrokeratoderma 9.9
49 hhv-6 encephalitis 9.9
50 tremor 9.9

Graphical network of the top 20 diseases related to Wernicke Encephalopathy:



Diseases related to Wernicke Encephalopathy

Symptoms & Phenotypes for Wernicke Encephalopathy

UMLS symptoms related to Wernicke Encephalopathy:


ataxia, ophthalmoplegia

MGI Mouse Phenotypes related to Wernicke Encephalopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 GFAP GLUL MAPT SLC19A3 SLC1A2 SLC1A3
2 growth/size/body region MP:0005378 9.73 GFAP GLUL MAPT SLC19A3 SLC1A2 TKT
3 mortality/aging MP:0010768 9.7 GFAP GLUL MAPT SLC19A3 SLC1A2 SLC1A3
4 nervous system MP:0003631 9.56 GFAP GLUL INA MAPT SLC19A3 SLC1A2
5 normal MP:0002873 9.02 GFAP GLUL INA MAPT SLC1A2

Drugs & Therapeutics for Wernicke Encephalopathy

Drugs for Wernicke Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 59-43-8, 70-16-6 1130
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 59-30-3 6037
3 Vitamins Phase 4,Phase 2,Phase 3,Not Applicable
4 Thiamin Phase 4,Phase 2,Phase 3,Not Applicable
5 Vitamin B Complex Phase 4,Phase 2,Phase 3
6 Trace Elements Phase 4,Phase 2,Phase 3
7 Micronutrients Phase 4,Phase 2,Phase 3
8 Vitamin B9 Phase 4,Phase 2,Phase 3
9 Folate Phase 4,Phase 2,Phase 3
10
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
11
Ethanol Approved Phase 2, Phase 3 64-17-5 702
12
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
13
Promethazine Approved, Investigational Phase 3 60-87-7 4927
14
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
15 Analgesics Phase 2, Phase 3
16 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
17 Gastrointestinal Agents Phase 3
18 Anticonvulsants Phase 2, Phase 3
19 Calcium, Dietary Phase 2, Phase 3
20 Anesthetics Phase 2, Phase 3,Phase 3
21 calcium channel blockers Phase 2, Phase 3
22 Anti-Arrhythmia Agents Phase 2, Phase 3
23 Central Nervous System Depressants Phase 2, Phase 3,Phase 3
24 Tocolytic Agents Phase 2, Phase 3
25 Anti-Allergic Agents Phase 3
26
Histamine Phosphate Phase 3 51-74-1 65513
27 Autonomic Agents Phase 3
28 Neurotransmitter Agents Phase 3
29 Histamine H1 Antagonists Phase 3
30 Anesthetics, Local Phase 3
31 Antiemetics Phase 3
32 Antipruritics Phase 3
33 Dermatologic Agents Phase 3
34 Histamine Antagonists Phase 3
35 Hypnotics and Sedatives Phase 3
36
Etanercept Approved, Investigational 185243-69-0
37
Adalimumab Approved 331731-18-1 16219006
38
Tofacitinib Approved, Investigational 477600-75-2
39 pyruvate Not Applicable
40 Anti-Inflammatory Agents
41 Immunosuppressive Agents
42 Anti-Inflammatory Agents, Non-Steroidal
43 Immunologic Factors
44 Analgesics, Non-Narcotic
45 Antirheumatic Agents
46 Protein Kinase Inhibitors

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpTIn) Trial Recruiting NCT02788552 Phase 4 Thiamine Hydrochloride
2 Alcohol: Thiamine and or Magnesium 1 Recruiting NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 An Efficacy and Safety Trial of Fedratinib in Subjects With DIPSS, Intermediate or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib Not yet recruiting NCT03755518 Phase 3 FEDRATINIB
4 Does Thiamine Help Vomiting and Nausea in Pregnancy? Terminated NCT00861523 Phase 3 thiamine & promethazine
5 Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Unknown status NCT00567281 Phase 2
6 Transcranial Magnetic Stimulation for "Voices" Completed NCT00308997 Phase 2
7 From Uncomplicated Alcoholism to Korsakoff's Syndrome Unknown status NCT01455207 Not Applicable
8 Study of the Effect of Transcranial Stimulations in Aphasic Subject Within a Year of Their Stroke Unknown status NCT02101398 Not Applicable
9 Models of Disordered Knowledge and Memory Systems in Dementia and Related Disorders Completed NCT00004557
10 A Study To Evaluate The Efficacy Of Enbrel (REGISTERED) Etanercept Over A Period Of 12 Months In The Routine Treatment Of Patients With Rheumatoid Arthritis, Axial Spondyloarthritis, Psoriatic Arthritis, Or Plaque Psoriasis. Completed NCT02486302 Etanercept
11 Safety and Effect on Quality of Life/Work Productivity of Humira in Patients With Rheumatoid Arthritis Completed NCT01076205
12 MRI and Diffusion Imaging of Eloquent Brain Areas to Optimize Brain Tumor Resection Planning Recruiting NCT01534104 Not Applicable
13 Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study Recruiting NCT03724136 Not Applicable
14 Modeling Treated Recovery From Aphasia Recruiting NCT03416738 Not Applicable
15 Observational Study to Determine How Physicians Make Treatment Decisions in Patients Treated With Tofacitinib for Moderate to Severe Active Rheumatoid Arthritis Recruiting NCT03387423 Tofacitinib
16 Repetitive Transcranial Magnetic Stimulation in Patients With Alzheimer Disease Active, not recruiting NCT03270137 Not Applicable
17 The Effect of tDCS on Subcortical Brain Functioning Terminated NCT01602276 Not Applicable

Search NIH Clinical Center for Wernicke Encephalopathy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: wernicke encephalopathy

Genetic Tests for Wernicke Encephalopathy

Anatomical Context for Wernicke Encephalopathy

MalaCards organs/tissues related to Wernicke Encephalopathy:

41
Brain, Liver, Lung, T Cells, Occipital Lobe, Temporal Lobe, Thalamus

Publications for Wernicke Encephalopathy

Articles related to Wernicke Encephalopathy:

(show top 50) (show all 668)
# Title Authors Year
1
A Case of Wernicke Encephalopathy Developing After Ileal Bypass Surgery. ( 29596284 )
2018
2
Wernicke Encephalopathy Following Laparoscopic Sleeve Gastrectomy-a Call to Evaluate Thiamine Deficiencies After Restrictive Bariatric Procedures. ( 29307105 )
2018
3
Preventing Wernicke Encephalopathy After Bariatric Surgery. ( 29693218 )
2018
4
Wernicke encephalopathy without delirium that appeared as agitation in a patient with lung cancer. ( 29747720 )
2018
5
Convergence Spasm in Wernicke Encephalopathy. ( 29276567 )
2018
6
Wernicke's encephalopathy in a child with autism during chemotherapy for T-cell acute leukemia. ( 30160032 )
2018
7
Preventing Wernicke's encephalopathy in anorexia nervosa: A systematic review. ( 29984541 )
2018
8
Postseizure aphasia in Wernicke's encephalopathy: a case report and review of literature. ( 30349257 )
2018
9
Gastrointestinal beriberi: a forme fruste of Wernicke's encephalopathy? ( 29982183 )
2018
10
An autopsied case of MM1-type sporadic Creutzfeldt-Jakob disease with pathology of Wernicke encephalopathy. ( 30409087 )
2018
11
Thiamine Prescribing and Wernicke's Encephalopathy Risk Factors in Patients With Alcohol Use Disorders at a Psychiatric Hospital. ( 30427818 )
2018
12
Dracula teeth-like image on MRI of a patient with non alcoholic Wernicke encephalopathy. ( 30453205 )
2018
13
Wernicke's encephalopathy in a patient with non-Hodgkin's lymphoma post-Autologous HSCT. ( 30517233 )
2018
14
Wernicke Encephalopathy with Atypical Findings on Magnetic Resonance Imaging. ( 30532369 )
2018
15
Review of thiamine deficiency disorders: Wernicke encephalopathy and Korsakoff psychosis. ( 30281514 )
2018
16
Conversion of upbeat to downbeat nystagmus in Wernicke encephalopathy. ( 30348852 )
2018
17
Wernicke's Encephalopathy. ( 30364782 )
2018
18
Wernicke encephalopathy in a lung cancer patient during treatment with nivolumab. ( 30073944 )
2018
19
B Minus: Wernicke's Encephalopathy. ( 30102912 )
2018
20
Optic Discs Swelling Procrastinates Wernicke's Encephalopathy Associated with Hyperemesis Gravidarum: A Case Report and Review of Literature. ( 30112269 )
2018
21
Progressive supranuclear palsy responding to intravenous thiamine: superimposed Wernicke's encephalopathy? ( 30131406 )
2018
22
Wernicke Encephalopathy Due to Hyperemesis Gravidarum in Pregnancy: A Case Report. ( 30237950 )
2018
23
Wernicke encephalopathy: (MRI) picture worth a thousand words. ( 29868178 )
2018
24
Wernicke's Encephalopathy as a Rare Complication of Hyperemesis Gravidarum: A Case Report and Review of Literature. ( 30013861 )
2018
25
Wernicke's encephalopathy after cardiac surgery. ( 29667898 )
2018
26
Case Report of Wernicke's Encephalopathy After Sleeve Gastrectomy. ( 29730896 )
2018
27
Early detection and successful treatment of Wernicke's encephalopathy in outpatients without the complete classic triad of symptoms who attended a psycho-oncology clinic. ( 29478423 )
2018
28
Ocular manifestations in a case of Wernicke's encephalopathy due to hyperemesis gravidarum. ( 29563707 )
2018
29
Vestibular Dysfunction in Wernicke's Encephalopathy: Predominant Impairment of the Horizontal Semicircular Canals. ( 29593640 )
2018
30
Wernicke's Encephalopathy 5 Years After a Whipple Procedure. ( 29623164 )
2018
31
Impairment of Thiamine Transport at the GUT-BBB-AXIS Contributes to Wernicke's Encephalopathy. ( 29128903 )
2018
32
Antecedent diffuse cerebellar lesions on diffusion-weighted MRI in nonalcoholic Wernicke's encephalopathy. ( 29143148 )
2018
33
Wernicke's encephalopathy following reduced food intake due to depressive disorders. ( 28410563 )
2018
34
Prolonged hypotension associated with Wernicke's encephalopathy. ( 28901332 )
2018
35
Wernicke encephalopathy in a patient after liver transplantation: A case report. ( 29308003 )
2017
36
A rare complication of vomiting in pregnancy: Wernicke encephalopathy. ( 28456382 )
2017
37
Wernicke Encephalopathy ( 29261914 )
2017
38
A case report: Non-alcoholic Wernicke encephalopathy associated with polyneuropathy. ( 28367669 )
2017
39
Differences Between Alcoholic and Nonalcoholic Patients With Wernicke Encephalopathy: A Multicenter Observational Study. ( 28578781 )
2017
40
Malnutrition in the elderly and Wernicke encephalopathy. ( 28363380 )
2017
41
Hypomagnesaemia as a trigger of relapsing non-alcoholic Wernicke encephalopathy: a case report. ( 28730572 )
2017
42
Wernicke Encephalopathy in a Patient with Pulmonary and Abdominal Tuberculosis. ( 29133769 )
2017
43
Wernicke encephalopathy without delirium in patients with cancer. ( 28464962 )
2017
44
Optic Chiasm Involvement With Concurrent Typical Wernicke Encephalopathy Magnetic Resonance Findings: A Case Report. ( 29029866 )
2017
45
More than a Case Report? Should Wernicke Encephalopathy After Sleeve Gastrectomy be a Concern? ( 28733807 )
2017
46
A patient with a 'typical presentation' of Wernicke encephalopathy was found to have sporadic Creutzfeldt-Jakob disease. ( 28653943 )
2017
47
Fundus Findings in Wernicke Encephalopathy. ( 28924437 )
2017
48
Wernicke's Encephalopathy in a Patient Without Chronic Alcohol Abuse. ( 29849420 )
2017
49
Recurrent Wernicke's encephalopathy in pregnancy: A case report. ( 29272216 )
2017
50
Are Psychiatric Inpatients at Risk of Developing Wernicke's Encephalopathy Being Identified and Adequately Treated? ( 29286589 )
2017

Variations for Wernicke Encephalopathy

Expression for Wernicke Encephalopathy

Search GEO for disease gene expression data for Wernicke Encephalopathy.

Pathways for Wernicke Encephalopathy

Pathways related to Wernicke Encephalopathy according to KEGG:

37
# Name Kegg Source Accession
1 Vitamin digestion and absorption hsa04977

Pathways related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 GFAP MAPT SLC1A2 SLC1A3
2 11.05 GFAP SLC1A3
3
Show member pathways
9.7 GLUL SLC1A2 SLC1A3

GO Terms for Wernicke Encephalopathy

Cellular components related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.67 GFAP GLUL MAPT SLC1A3
2 neuron projection GO:0043005 9.63 GLUL MAPT SLC1A3
3 cytoplasmic ribonucleoprotein granule GO:0036464 9.43 INA MAPT
4 intermediate filament cytoskeleton GO:0045111 9.4 GFAP INA
5 cell body GO:0044297 9.33 GFAP GLUL MAPT
6 axolemma GO:0030673 9.32 MAPT SLC1A2
7 neurofilament GO:0005883 9.26 GFAP INA
8 myelin sheath GO:0043209 9.26 GFAP GLUL INA TKT
9 glial cell projection GO:0097386 8.8 GFAP GLUL MAPT

Biological processes related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transport GO:0006865 9.48 SLC1A2 SLC1A3
2 response to light stimulus GO:0009416 9.46 SLC1A2 SLC1A3
3 glutamate metabolic process GO:0006536 9.43 GLUL SLC1A3
4 glutamate secretion GO:0014047 9.4 SLC1A2 SLC1A3
5 axon development GO:0061564 9.37 GFAP MAPT
6 L-glutamate transmembrane transport GO:0015813 9.32 SLC1A2 SLC1A3
7 neurotransmitter uptake GO:0001504 9.26 GLUL SLC1A3
8 L-glutamate import across plasma membrane GO:0098712 9.16 SLC1A2 SLC1A3
9 response to wounding GO:0009611 9.13 GFAP SLC1A2 SLC1A3
10 D-aspartate import across plasma membrane GO:0070779 8.62 SLC1A2 SLC1A3

Molecular functions related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid transmembrane transporter activity GO:0015171 9.32 SLC1A2 SLC1A3
2 L-glutamate transmembrane transporter activity GO:0005313 9.26 SLC1A2 SLC1A3
3 glutamate binding GO:0016595 9.16 GLUL SLC1A3
4 high-affinity glutamate transmembrane transporter activity GO:0005314 8.96 SLC1A2 SLC1A3
5 glutamate:sodium symporter activity GO:0015501 8.62 SLC1A2 SLC1A3

Sources for Wernicke Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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