MCID: WRN003
MIFTS: 47

Wernicke Encephalopathy

Categories: Metabolic diseases, Neuronal diseases

Aliases & Classifications for Wernicke Encephalopathy

MalaCards integrated aliases for Wernicke Encephalopathy:

Name: Wernicke Encephalopathy 12 36 54 43 15 17 71 32
Wernicke's Encephalopathy 12 74
Wernicke-Korsakoff Syndrome 71
Wernicke's Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2384
KEGG 36 H01565
MeSH 43 D014899
SNOMED-CT 67 21007002
ICD10 32 E51.2
UMLS 71 C0043121 C0349464

Summaries for Wernicke Encephalopathy

KEGG : 36 Wernicke encephalopathy is a rare but serious neurological pathology due to a vitamin B1 deficiency. It is commonly associated with heavy alcohol consumption. Other clinical associations are with hyperemesis gravidarum, starvation, and prolonged intravenous feeding. Most patients present with the triad of ophthalmoplegia, ataxia, and confusion. It can be associated with life-threatening complication like central pontine myelinolysis. When Wernicke encephalopathy is suspected, treatment with high-dose parenteral thiamine (vitamin B1) should be given. If it is not treated promptly or if treatment is inadequate it can lead to death or to the chronic memory disorder, Korsakoff syndrome. Recent studies have suggested that an association exists between Wernicke encephalopathy and genetic polymorphisms in the thiamine transporter (SLC19A2).

MalaCards based summary : Wernicke Encephalopathy, also known as wernicke's encephalopathy, is related to wernicke-korsakoff syndrome and amnestic disorder, and has symptoms including ataxia and ophthalmoplegia. An important gene associated with Wernicke Encephalopathy is TKT (Transketolase), and among its related pathways/superpathways are Vitamin digestion and absorption and Glucose / Energy Metabolism. The drugs Magnesium Sulfate and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and eye, and related phenotypes are behavior/neurological and growth/size/body region

Disease Ontology : 12 A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1).

Wikipedia : 74 Wernicke encephalopathy (WE), also Wernicke's encephalopathy is the presence of neurological symptoms... more...

Related Diseases for Wernicke Encephalopathy

Diseases related to Wernicke Encephalopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 314)
# Related Disease Score Top Affiliating Genes
1 wernicke-korsakoff syndrome 31.5 TPK1 TKT THTPA SLC19A3 SLC19A2 OGDH
2 amnestic disorder 30.6 TSPO MAPT GAD1
3 wet beriberi 30.5 TKT SLC19A3 SLC19A2
4 status epilepticus 30.3 TSPO SLC1A2 GFAP
5 alcoholic neuropathy 30.2 TKT THTPA
6 toxic encephalopathy 30.1 SLC1A3 SLC1A2 MAPT GFAP
7 beriberi 29.9 TSPO TPK1 TKT THTPA SLC19A3 SLC19A2
8 neuromyelitis optica 29.8 SLC1A2 GFAP AQP4
9 neuritis 29.6 MAPT GFAP AQP4
10 dry beriberi 29.6 TKT THTPA SLC19A3 SLC19A2
11 hepatic encephalopathy 29.5 TSPO SLC1A2 GLUL AQP4
12 brain edema 29.4 SLC1A2 GLUL GFAP AQP4
13 stroke, ischemic 28.9 TSPO SLC1A2 MAPT AQP4
14 schizophrenia 28.5 TSPO SLC1A3 SLC1A2 MAPT GLUL GFAP
15 cerebral beriberi 11.9
16 korsakoff's amnesic syndrome 11.5
17 encephalopathy 11.2
18 ataxia and polyneuropathy, adult-onset 10.8
19 pathologic nystagmus 10.6
20 alcohol dependence 10.6
21 kearns-sayre syndrome 10.6
22 subacute delirium 10.5
23 alcohol use disorder 10.5
24 leptin deficiency or dysfunction 10.4
25 neuropathy 10.4
26 ocular motor apraxia 10.4
27 human immunodeficiency virus type 1 10.3
28 creutzfeldt-jakob disease 10.3
29 body mass index quantitative trait locus 11 10.3
30 body mass index quantitative trait locus 9 10.3
31 body mass index quantitative trait locus 8 10.3
32 body mass index quantitative trait locus 4 10.3
33 body mass index quantitative trait locus 10 10.3
34 body mass index quantitative trait locus 7 10.3
35 body mass index quantitative trait locus 12 10.3
36 body mass index quantitative trait locus 14 10.3
37 body mass index quantitative trait locus 18 10.3
38 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
39 body mass index quantitative trait locus 19 10.3
40 body mass index quantitative trait locus 20 10.3
41 acute pancreatitis 10.3
42 pancreatitis 10.3
43 peripheral nervous system disease 10.3
44 binswanger's disease 10.3 MAPT GFAP
45 yemenite deaf-blind hypopigmentation syndrome 10.3
46 leukemia, acute lymphoblastic 10.3
47 metabolic acidosis 10.3
48 polyneuropathy 10.3
49 optic nerve disease 10.3
50 central pontine myelinolysis 10.3

Graphical network of the top 20 diseases related to Wernicke Encephalopathy:



Diseases related to Wernicke Encephalopathy

Symptoms & Phenotypes for Wernicke Encephalopathy

UMLS symptoms related to Wernicke Encephalopathy:


ataxia, ophthalmoplegia

MGI Mouse Phenotypes related to Wernicke Encephalopathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.24 AQP4 GAD1 GFAP GLUL JAK1 JAK2
2 growth/size/body region MP:0005378 10.13 AQP4 GAD1 GFAP GLUL JAK1 JAK2
3 homeostasis/metabolism MP:0005376 10.03 AQP4 GAD1 GFAP GLUL JAK1 JAK2
4 mortality/aging MP:0010768 10.03 AQP4 GAD1 GFAP GLUL JAK1 JAK2
5 nervous system MP:0003631 9.73 AQP4 GAD1 GFAP GLUL INA MAPT
6 normal MP:0002873 9.32 GAD1 GFAP GLUL INA JAK1 JAK2

Drugs & Therapeutics for Wernicke Encephalopathy

Drugs for Wernicke Encephalopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 2, Phase 3 7487-88-9 24083
2
Ethanol Approved Phase 3 64-17-5 702
3
Promethazine Approved, Investigational Phase 3 60-87-7 4927
4
Histamine Approved, Investigational Phase 3 51-45-6 774
5
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
6
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 3 59-43-8, 70-16-6 1130
8 Hormones Phase 2, Phase 3
9 Anti-Arrhythmia Agents Phase 2, Phase 3
10 Tocolytic Agents Phase 2, Phase 3
11 Anticonvulsants Phase 2, Phase 3
12 Analgesics Phase 2, Phase 3
13 Calcium, Dietary Phase 2, Phase 3
14 calcium channel blockers Phase 2, Phase 3
15 Trace Elements Phase 3
16 Micronutrients Phase 3
17 Vitamins Phase 3
18 Anesthetics Phase 3
19 Vitamin B Complex Phase 3
20 Thiamin Phase 3
21 Nutrients Phase 3
22 Folate Phase 3
23 Vitamin B9 Phase 3
24 Neurotransmitter Agents Phase 3
25 Gastrointestinal Agents Phase 3
26 Hypnotics and Sedatives Phase 3
27 Anti-Allergic Agents Phase 3
28 Histamine Antagonists Phase 3
29 Histamine H1 Antagonists Phase 3
30 Antiemetics Phase 3
31 Dermatologic Agents Phase 3
32
Histamine Phosphate Phase 3 51-74-1 65513
33 Anesthetics, Local Phase 3
34
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
35
Hydrocortisone Approved, Vet_approved 50-23-7 5754
36
Hydrocortisone acetate Approved, Vet_approved 50-03-3
37
Metoclopramide Approved, Investigational 364-62-5 4168
38
Dopamine Approved 51-61-6, 62-31-7 681
39 pyruvate
40 Emetics
41 Dopamine Antagonists
42 Hydrocortisone 17-butyrate 21-propionate
43 Hydrocortisone hemisuccinate
44 Dopamine Agents
45 Anti-Inflammatory Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optimum Thiamine Intervention (OpT In) for Treatment and Prevention of Wernicke-Korsakoff Syndrome (WKS): A Randomised Controlled Trial Completed NCT02788552 Phase 4 Thiamine Hydrochloride
2 A Prospective Randomised Controlled Trial of the Effect of Magnesium Sulphate Administration on Red Cell Transketolase Activity in Alcohol Dependent Patients at Risk of Wernicke Korsakoff Syndrome Treated With Thiamine Completed NCT03466528 Phase 2, Phase 3 Magnesium Sulfate;Pabrinex
3 Multicenter Randomized Placebo Controlled Trial Assessing the Efficacy of Oral Adjuvant Magnesium Supplementation in the Treatment of Alcohol Withdrawal Syndrome Recruiting NCT03033823 Phase 3 Magnesium;Placebo Oral Tablet
4 Comparison Between the Treatment of Thiamine and Promethazine for Improving Vomiting and Nausea in Pregnancy Terminated NCT00861523 Phase 3 thiamine & promethazine
5 From Uncomplicated Alcoholism to Korsakoff's Syndrome: Clinical, Genetic, Neuropsychological and Brain Examinations Unknown status NCT01455207
6 Efficacy of Thiamine Supplement for Improve Cardiovascular Function in Patients With Severe Hyperthyroidism Completed NCT02767245 Thiamine
7 Randomized Controlled Trial of Day Care Versus Inpatient Management of Nausea and Vomiting of Pregnancy Completed NCT00795561
8 Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study Recruiting NCT03724136
9 Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients: A Prospective Randomized Study Recruiting NCT03649009 Thiamine;Hydrocortisone

Search NIH Clinical Center for Wernicke Encephalopathy

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Thiamine hydrochloride
Thiamine Mononitrate

Cochrane evidence based reviews: wernicke encephalopathy

Genetic Tests for Wernicke Encephalopathy

Anatomical Context for Wernicke Encephalopathy

MalaCards organs/tissues related to Wernicke Encephalopathy:

40
Brain, Liver, Eye, Thalamus, Cerebellum, Bone Marrow, Bone

Publications for Wernicke Encephalopathy

Articles related to Wernicke Encephalopathy:

(show top 50) (show all 1407)
# Title Authors PMID Year
1
Quantitative autoradiography using selective radioligands for central and peripheral-type benzodiazepine receptors in experimental Wernicke's encephalopathy: implications for positron emission tomography imaging. 61 54
8727262 1996
2
ANNALS EXPRESS: Don't seek, don't find: the diagnostic challenge of Wernicke's encephalopathy. 61
32551830 2020
3
Sensorineural Hearing Loss and Wernicke Encephalopathy: A Case Report and Literature Review. 61
32521993 2020
4
A Case Report of Nonalcoholic Gayet-Wernicke Encephalopathy: Don't Miss Thiamine. 61
32496424 2020
5
Wernicke's Encephalopathy: Similar and Different Aspects of the Three Cases. 61
32550785 2020
6
Missing the early signs of thiamine deficiency. A case associated with a liquid-only diet. 61
30092713 2020
7
Comprehensive review of Wernicke encephalopathy: pathophysiology, clinical symptoms and imaging findings. 61
32390125 2020
8
Wernicke-Korsakoff Syndrome: A Case Series in Liaison Psychiatry. 61
32391987 2020
9
Wernicke's encephalopathy in a patient with late-onset enterocolic fistula after bariatric surgery. 61
32338021 2020
10
[Thiamin and alcohol use disorder: A national survey of practice]. 61
31587815 2020
11
Wernicke's encephalopathy due to malnutrition and parenteral nutrition in a patient with cerebral infarction: A case report. 61
32311995 2020
12
Optic neuropathy in Wernicke encephalopathy: More than meets the eye? 61
32392503 2020
13
Wernicke Encephalopathy and Lactic Acidosis in Thiamine Deficiency. 61
32284483 2020
14
Wernicke encephalopathy-a rare complication of hyperemesis gravidarum. 61
32123344 2020
15
Fedratinib in myelofibrosis. 61
32343799 2020
16
Rapid same-day resolution of internuclear ophthalmoplegia in Wernicke encephalopathy following parenteral high dose thiamine. 61
31712022 2020
17
Vision loss, gaze palsy, and nystagmus in a patient with leukemia. 61
32360161 2020
18
Wernicke's encephalopathy, refeeding syndrome and wet beriberi after laparoscopic sleeve gastrectomy: the importance of thiamine evaluation. 61
32047291 2020
19
Cognitive impairment severity in relation to signs of subclinical Wernicke's encephalopathy in HIV and alcoholism comorbidity. 61
31725430 2020
20
Non-alcoholic beriberi, Wernicke encephalopathy and long-term eating disorder: case report and a mini-review. 61
32130681 2020
21
Wernicke's Encephalopathy Presenting as Sensorineural Hearing Loss. 61
32328388 2020
22
Wernicke encephalopathy associated with hyperemesis gravidarum. 61
31784394 2020
23
Wernicke encephalopathy. 61
32041699 2020
24
Brain 18FDG-PET pattern in patients with alcohol-related cognitive impairment. 61
31428832 2020
25
Alcohol use disorders and the brain. 61
32112474 2020
26
Eye movements in demyelinating, autoimmune and metabolic disorders. 61
31770124 2020
27
Focal hyperemia in Wernicke's encephalopathy: a preliminary arterial spin labeling MRI study. 61
31732755 2020
28
Scurvy and Wernicke's encephalopathy: An underdiagnosed association? 61
28720337 2020
29
Incidence of Adverse Reactions to Parenteral Thiamine in the Treatment of Wernicke's Encephalopathy, and Recommendations. 61
31565743 2019
30
Stability of high-dose thiamine in parenteral nutrition for treatment of patients with Wernicke's encephalopathy. 61
31866128 2019
31
CLINICAL PRACTICE GUIDELINES FOR THE PERIOPERATIVE NUTRITION, METABOLIC, AND NONSURGICAL SUPPORT OF PATIENTS UNDERGOING BARIATRIC PROCEDURES - 2019 UPDATE: COSPONSORED BY AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/AMERICAN COLLEGE OF ENDOCRINOLOGY, THE OBESITY SOCIETY, AMERICAN SOCIETY FOR METABOLIC & BARIATRIC SURGERY, OBESITY MEDICINE ASSOCIATION, AND AMERICAN SOCIETY OF ANESTHESIOLOGISTS - EXECUTIVE SUMMARY. 61
31682518 2019
32
Atypical presentation of a forgotten disease: refractory hypotension in beriberi. 61
31285553 2019
33
Nonalcoholic Wernicke's Encephalopathy Followed by Neuromyelitis Optica Spectrum Disorders: A Case Report. 61
31857564 2019
34
Wernicke's encephalopathy. 61
31735353 2019
35
Case of non-alcoholic Wernicke's encephalopathy. 61
31732541 2019
36
Nonalcoholic Wernicke's encephalopathy: a retrospective study of 17 cases. 61
31502510 2019
37
Functional neurological symptoms masquerading as Wernicke encephalopathy following bariatric surgery. 61
31656438 2019
38
Subclinical thiamine deficiency identified by preoperative evaluation in an ovarian cancer patient: Diagnosis and the need for preoperative thiamine measurement. 61
30168403 2019
39
Malnutrition in the elderly and Wernicke encephalopathy. 61
28363380 2019
40
A Case of Ascending Sensory Neuropathy Due to Acute Onset Thiamine Deficiency After Intragastric Balloon Placement. 61
31134479 2019
41
Wernicke encephalopathy following gastrojejunostomy: A case report and review of the literature. 61
31687617 2019
42
Metronidazole induced encephalopathy: case report and discussion on the differential diagnoses, in particular, Wernicke's encephalopathy. 61
32184926 2019
43
Vertical nystagmus in Wernicke's encephalopathy: pathogenesis and role of central processing of information from the otoliths. 61
31028542 2019
44
Vision Loss As a Presenting Feature of Wernicke Encephalopathy. 61
30829946 2019
45
Nausea and vomiting of pregnancy and hyperemesis gravidarum. 61
31515515 2019
46
[Gayet-Wernicke's encephalopathy after bariatric surgery]. 61
31473023 2019
47
Thiamine Deficiency in a Child with Short Bowel Syndrome and Review. 61
31555575 2019
48
Hyperemesis gravidarum causing Wernicke-Korsakoff syndrome: A rare complication. 61
31215137 2019
49
Posterior reversible encephalopathy syndrome and Wernicke encephalopathy in patient with acute graft-versus-host disease. 61
31193981 2019
50
Ataxia. 61
31356292 2019

Variations for Wernicke Encephalopathy

Expression for Wernicke Encephalopathy

Search GEO for disease gene expression data for Wernicke Encephalopathy.

Pathways for Wernicke Encephalopathy

Pathways related to Wernicke Encephalopathy according to KEGG:

36
# Name Kegg Source Accession
1 Vitamin digestion and absorption hsa04977

GO Terms for Wernicke Encephalopathy

Cellular components related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell projection GO:0042995 9.88 SLC1A3 MRI1 MAPT GLUL GFAP AQP4
2 axolemma GO:0030673 9.37 SLC1A2 MAPT
3 astrocyte projection GO:0097449 9.32 SLC1A2 GFAP
4 astrocyte end-foot GO:0097450 9.26 GFAP AQP4
5 cell body GO:0044297 9.26 SLC1A2 MAPT GLUL GFAP
6 membrane protein complex GO:0098796 9.16 SLC1A3 SLC1A2
7 glial cell projection GO:0097386 8.8 MAPT GLUL GFAP

Biological processes related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 10 SLC1A3 SLC1A2 SLC19A3 SLC19A2 AQP4
2 response to drug GO:0042493 9.88 TSPO SLC1A3 SLC1A2 GAD1
3 response to wounding GO:0009611 9.69 SLC1A3 SLC1A2 GFAP
4 positive regulation of glial cell proliferation GO:0060252 9.61 TSPO GFAP
5 interleukin-6-mediated signaling pathway GO:0070102 9.59 JAK2 JAK1
6 L-glutamate transmembrane transport GO:0015813 9.58 SLC1A3 SLC1A2
7 neurotransmitter uptake GO:0001504 9.57 SLC1A3 GLUL
8 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.56 JAK2 JAK1
9 interleukin-35-mediated signaling pathway GO:0070757 9.55 JAK2 JAK1
10 interleukin-27-mediated signaling pathway GO:0070106 9.54 JAK2 JAK1
11 transepithelial transport GO:0070633 9.52 SLC1A3 SLC1A2
12 vitamin transport GO:0051180 9.49 SLC19A3 SLC19A2
13 L-glutamate import across plasma membrane GO:0098712 9.48 SLC1A3 SLC1A2
14 vitamin transmembrane transport GO:0035461 9.46 SLC19A3 SLC19A2
15 D-aspartate import across plasma membrane GO:0070779 9.43 SLC1A3 SLC1A2
16 thiamine metabolic process GO:0006772 9.4 TPK1 THTPA
17 glutamate catabolic process GO:0006538 9.37 GLUL GAD1
18 thiamine transmembrane transport GO:0071934 9.32 SLC19A3 SLC19A2
19 thiamine transport GO:0015888 9.26 SLC19A3 SLC19A2
20 gamma-aminobutyric acid biosynthetic process GO:0009449 9.16 SLC1A3 GAD1
21 response to antibiotic GO:0046677 9.13 SLC1A3 JAK2 JAK1
22 thiamine-containing compound metabolic process GO:0042723 8.92 TPK1 THTPA SLC19A3 SLC19A2

Molecular functions related to Wernicke Encephalopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 L-glutamate transmembrane transporter activity GO:0005313 9.43 SLC1A3 SLC1A2
2 growth hormone receptor binding GO:0005131 9.4 JAK2 JAK1
3 thiamine pyrophosphate binding GO:0030976 9.37 TKT OGDH
4 vitamin transmembrane transporter activity GO:0090482 9.32 SLC19A3 SLC19A2
5 high-affinity glutamate transmembrane transporter activity GO:0005314 9.26 SLC1A3 SLC1A2
6 glutamate:sodium symporter activity GO:0015501 9.16 SLC1A3 SLC1A2
7 thiamine transmembrane transporter activity GO:0015234 8.96 SLC19A3 SLC19A2
8 glutamate binding GO:0016595 8.8 SLC1A3 GLUL GAD1

Sources for Wernicke Encephalopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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