West Nile Encephalitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: WST004 MIFTS: 44	West Nile Encephalitis Categories: Infectious diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for West Nile Encephalitis

MalaCards integrated aliases for West Nile Encephalitis:

Name: West Nile Encephalitis ¹² ¹⁵ ¹⁷

West Nile Fever ⁴⁴ ⁷¹

West Nile Fever with Encephalitis ¹²

Encephalitis, West Nile Fever ⁷¹

West Nile Fever Encephalitis ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2365

ICD9CM ³⁴ 066.41

MeSH ⁴⁴ D014901

SNOMED-CT ⁶⁷ 392662004

ICD10 ³² A92.31

EFO ¹⁷ EFO_0007545

UMLS ⁷¹ C0043124 C0751583

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Summaries for West Nile Encephalitis

Disease Ontology : ¹² A viral infectious disease that results in inflammation located in brain, has material basis in West Nile virus, which is transmitted by Culex, transmitted by Aedes, and transmitted by Anopheles species of mosquitoes. The infection has symptom high fever, has symptom headache, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, has symptom muscle weakness, has symptom vision loss, has symptom numbness, and has symptom paralysis.

MalaCards based summary : West Nile Encephalitis, also known as west nile fever, is related to west nile virus and bell's palsy, and has symptoms including muscle weakness, headache and coma. An important gene associated with West Nile Encephalitis is CHKA (Choline Kinase Alpha), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include kidney, b cells and lymph node, and related phenotypes are hematopoietic system and mortality/aging

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Related Diseases for West Nile Encephalitis

Diseases in the West Nile Encephalitis family:

West Nile Virus Encephalitis

Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)

#	Related Disease	Score	Top Affiliating Genes
1	west nile virus	32.5	OAS1 CLEC4M CCR5
2	bell's palsy	30.5	CD8A CD4
3	chikungunya	30.5	TLR7 OAS3 OAS1
4	orchitis	30.4	CD8A CD4
5	west nile virus infection	30.4	RNASEL OASL OAS1 CCR5
6	plague	30.2	CD8A CD4 CCR5
7	tick-borne encephalitis	30.1	OAS3 OAS1 CCR5
8	viral infectious disease	29.5	TLR9 TLR7 RNASEL OAS1 CLEC4M CD4
9	systemic lupus erythematosus	29.1	TLR9 TLR7 OASL OAS1 CD4 CCR5
10	west nile fever	29.1	RNASEL OASL OAS3 OAS1 CLEC4M CD8A
11	west nile virus encephalitis	11.6
12	kunjin encephalitis	11.3
13	encephalitis	11.0
14	meningoencephalitis	10.4
15	aseptic meningitis	10.4
16	japanese encephalitis	10.4
17	cork-handlers' disease	10.3	CD8A CD4
18	necrotic uveal melanoma	10.3	CD8A CD4
19	lymphopenia	10.3
20	early yaws	10.3	CD8A CD4
21	ventilation pneumonitis	10.3	CD8A CD4
22	diffuse infiltrative lymphocytosis syndrome	10.3	CD8A CD4
23	latent syphilis	10.3	CD8A CD4
24	type 1 diabetes mellitus 23	10.3	CD8A CD4
25	autoimmune lymphoproliferative syndrome, type iia	10.3	CD8A CD4
26	parapsoriasis	10.3	CD8A CD4
27	gastroduodenitis	10.3	CD8A CD4
28	duodenitis	10.3	CD8A CD4
29	primary syphilis	10.3	CD8A CD4
30	norwegian scabies	10.3	CD8A CD4
31	bird fancier's lung	10.3	CD8A CD4
32	skin sarcoidosis	10.3	CD8A CD4
33	metal allergy	10.3	CD8A CD4
34	variola major	10.3	CD8A CD4
35	follicular mucinosis	10.3	CD8A CD4
36	tertiary syphilis	10.3	CD8A CD4
37	spongiotic dermatitis	10.3	CD8A CD4
38	acute retinal necrosis syndrome	10.3	CD8A CD4
39	cerebral lymphoma	10.3	CD8A CD4
40	oral tuberculosis	10.3	CD8A CD4
41	cerebritis	10.3	CD8A CD4
42	rift valley fever	10.3
43	coccidioidomycosis	10.3
44	invasive malignant thymoma	10.3	CD8A CD4
45	granulomatous hepatitis	10.3	CD8A CD4
46	exanthema subitum	10.3	CD8A CD4
47	immunodeficiency 36	10.3	CD8A CD4
48	viral exanthem	10.3	CD8A CD4
49	glanders	10.3	CD8A CD4
50	oral hairy leukoplakia	10.3	CD8A CD4

Graphical network of the top 20 diseases related to West Nile Encephalitis:

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Symptoms & Phenotypes for West Nile Encephalitis

Symptoms:

¹² (show all 12)

• muscle weakness
• headache
• coma
• paralysis
• numbness
• vision loss

• tremors
• disorientation
• convulsions
• neck stiffness
• high fever
• stupor

MGI Mouse Phenotypes related to West Nile Encephalitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.61	CCR5 CD4 CD8A CLEC4M ITPA OASL
2	mortality/aging	MP:0010768	9.32	CCR5 CD4 CD8A CHKA CLEC4M ITPA

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Drugs & Therapeutics for West Nile Encephalitis

Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Vaccines		Phase 2
2	Pharmaceutical Solutions		Phase 2
3	Immunologic Factors		Phase 2
4	Immunoglobulins		Phase 2
5	Antibodies		Phase 2
6	Antibodies, Monoclonal		Phase 2

Interventional clinical trials:

(show all 13)

#	Name	Status	NCT ID	Phase	Drugs
1	Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults	Completed	NCT00442169	Phase 2
2	Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults.	Completed	NCT00746798	Phase 2
3	Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus	Terminated	NCT00927953	Phase 2
4	Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis	Completed	NCT00094718	Phase 1
5	Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis	Completed	NCT00537147	Phase 1
6	A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects	Completed	NCT00300417	Phase 1	VRC-WNVDNA020-00-VP
7	A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers	Completed	NCT00106769	Phase 1	VRC-WNVDNA017-00-VP
8	Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3´Δ30 Chimeric Virus Vaccine (WN/DEN4Δ30), a Live Attenuated Vaccine for West Nile Encephalitis, in Flavivirus-naïve Adults 50-65 Years of Age	Completed	NCT02186626	Phase 1
9	An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease	Terminated	NCT00091845	Phase 1	AVI-4020 Injection
10	Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease	Completed	NCT00069303
11	Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease	Completed	NCT00138463
12	Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus	No longer available	NCT01206504
13	Prospective Investigation of Oxidative Stress in West Nile Virus Infection	Withdrawn	NCT04371003

Search NIH Clinical Center for West Nile Encephalitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵¹ :

Ribavirin

Cochrane evidence based reviews: west nile fever

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Genetic Tests for West Nile Encephalitis

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Anatomical Context for West Nile Encephalitis

MalaCards organs/tissues related to West Nile Encephalitis:

⁴⁰

Kidney, B Cells, Lymph Node, Pancreas, Skin, T Cells, Occipital Lobe

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Publications for West Nile Encephalitis

Articles related to West Nile Encephalitis:

(show top 50) (show all 560)

#	Title	Authors	PMID	Year
1	Arboviruses in the Astrakhan region of Russia for 2018 season: The development of multiplex PCR assays and analysis of mosquitoes, ticks, and human blood sera. ⁶¹	Nikiforova MA...Gintsburg AL	33421655	2021
2	Current Status and a Perspective of Mosquito-Borne Diseases in the Republic of Korea. ⁶¹	Im JH...Lee JS	33136531	2021
3	Predicting the spatio-temporal spread of West Nile virus in Europe. ⁶¹	Garcia-Carrasco JM...Real R	33411739	2021
4	Sero-prevalence of West Nile virus and Rift Valley fever virus infections among cattle under extensive production system in South Omo area, southern Ethiopia. ⁶¹	Endale A...Legesse M	33415465	2021
5	Environmental drivers, climate change and emergent diseases transmitted by mosquitoes and their vectors in southern Europe: A systematic review. ⁶¹	Brugueras S...Gomez-Barroso D	32810503	2020
6	West Nile Fever - Clinical and Epidemiological Characteristics. Review of the Literature and Contribution with Three Clinical Cases. ⁶¹	Kotsev S...Pishmisheva-Peleva M	33415935	2020
7	The Roles of Osteopontin in the Pathogenesis of West Nile Encephalitis. ⁶¹	Nazneen F...Bai F	33317005	2020
8	[Emerging vectorial diseases: West Nile fever, Bluetongue and Schmallenberg]. ⁶¹	Zientara S...Lecollinet S	33012789	2020
9	Molecular Characterisation of Cytochrome Oxidase I and Internal Transcribed Spacer 2 Fragments of Culiseta longiareolata. ⁶¹	Soltanbeiglu S...Chavshin AR	33269558	2020
10	Dengue Virus Strikes Back: Increased Future Risk of Severe Dengue Disease in Humans as a Result of Previous Exposure to Zika Virus. ⁶¹	Martin-Acebes MA...Jimenez de Oya N	33339098	2020
11	Autochthonous West Nile virus infection outbreak in humans, Leipzig, Germany, August to September 2020. ⁶¹	Pietsch C...Liebert UG	33213686	2020
12	Modeling the West Nile virus transfusion transmission risk in a nonoutbreak country associated with traveling donors. ⁶¹	Kiely P...Wood EM	32869276	2020
13	New onset of Bell's palsy in a patient with West Nile Encephalitis. ⁶¹	Vaysman T...Liu A	33088514	2020
14	Emerging Natural Focal Infectious Diseases in Russia: A Medical-Geographical Study. ⁶¹	Malkhazova S...Orlov D	33143199	2020
15	Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses. ⁶¹	Konkolova E...Boura E	32763313	2020
16	Investigation of Vector-Borne Viruses in Ticks, Mosquitos, and Ruminants in the Thrace District of Turkey. ⁶¹	Bilgin Z...Yilmaz H	32397953	2020
17	Pathogenicity of West Nile Virus Lineage 1 to German Poultry. ⁶¹	Holicki CM...Ziegler U	32899581	2020
18	West Nile Virus in Slovenia. ⁶¹	Knap N...Avsic-Zupanc T	32635155	2020
19	Biocontrol of mosquito vectors through herbal-derived silver nanoparticles: prospects and challenges. ⁶¹	Kumar D...Agrawal V	32385820	2020
20	Identification and characterization of long noncoding RNAs and their association with acquisition of blood meal in Culex quinquefasciatus. ⁶¹	Azlan A...Azzam G	32621332	2020
21	Synopsis of the mosquitoes (Diptera: Culicidae) of Romania. ⁶¹	PAstrav IR...Mihalca AD	33055623	2020
22	Arboviral diseases in pediatrics. ⁶¹	Martins MM...Cunha AJLAD	31605670	2020
23	The longitudinal health economic impact of viral encephalitis in the United States. ⁶¹	Kiyani M...Lad SP	32040394	2020
24	Seroprevalence of Rift Valley Fever and West Nile Fever in Cattle in Gambella Region, South West Ethiopia. ⁶¹	Asebe G...Legesse M	33244452	2020
25	Chromatin Structure and Function in Mosquitoes. ⁶¹	Lezcano OM...Gomez-Diaz E	33365050	2020
26	Viral Emerging Diseases: Challenges in Developing Vaccination Strategies. ⁶¹	Trovato M...De Berardinis P	33013898	2020
27	Retrospective review and current knowledge on the occurrence of West Nile virus in mosquito vectors, reservoirs and hosts in Slovakia (Central Europe). ⁶¹	Korytar L...Csank T	32551787	2020
28	Zoonotic Diseases in Oman: Successes, Challenges, and Future Directions. ⁶¹	Awaidy SA...Al Hashami H	31486732	2020
29	Fatal case of West Nile encephalitis associated with acute anteroseptal ST elevation myocardial infarction (STEMI): a case report. ⁶¹	Sabadi D...Vilibic-Cavlek T	32334492	2020
30	A first clinical case report of west nile viral encephalitis in poltava region of Ukraine. ⁶¹	Kotelevska TM...Purdenko TY	32731727	2020
31	Development of an Internally Controlled Reverse Transcription Recombinase-aided Amplification Assay for the Rapid and Visual Detection of West Nile Virus. ⁶¹	Fan GH...Wu GZ	31918798	2019
32	Baseline Susceptibility of Culiseta longiareolata (Diptera: Culicidae) to Different Imagicides, in Eastern Azerbaijan, Iran. ⁶¹	Hazratian T...Oshaghi MA	32368558	2019
33	Emerging viruses in older population Chikungunya, West Nile fever and Dengue. ⁶¹	Godaert L...Roubaud-Baudron C	31741192	2019
34	Ecological Niche Modeling of West Nile Virus Vector in Northwest of Iran. ⁶¹	Adham D...Saghafipour A	31745415	2019
35	Economic Burden of West Nile Virus Disease, Quebec, Canada, 2012-2013. ⁶¹	Ouhoummane N...Milord F	31538563	2019
36	West Nile fever in Europe in 2018: an emerging problem or just an anomaly? ⁶¹	Browne C...Medlock JM	31562277	2019
37	Evidence of West Nile Virus (WNV) Circulation in Wild Birds and WNV RNA Negativity in Mosquitoes of the Danube Delta Biosphere Reserve, Romania, 2016. ⁶¹	Vasic A...SCOPES AMSAR training group	31438608	2019
38	Spectrum of Movement Disorders in Patients With Neuroinvasive West Nile Virus Infection. ⁶¹	Lenka A...Mittal SO	31392241	2019
39	West Nile encephalitis mimicking neuropsychiatric lupus in a patient with systemic lupus erythematosus. ⁶¹	Iyer NR...Wallace BI	31345830	2019
40	Cognitive behavioural impairment with irreversible sensorineural deafness as a complication of West Nile encephalitis. ⁶¹	Pradhan S...Choudhury SS	30903400	2019
41	Flaviviruses and Kidney Diseases. ⁶¹	Burdmann EA	31202392	2019
42	Emergent Arboviruses and Renal Transplantation: A Global Challenge. ⁶¹	Moura-Neto JA...Rocco Suassuna JH	31080919	2019
43	Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions. ⁶¹	Song Y...Wimmer E	30967466	2019
44	Short Communication: West Nile fever imported from Austria to Germany. ⁶¹	Pietsch C...Liebert UG	30462884	2019
45	The Potential of West Nile Virus Transmission Regarding the Environmental Factors Using Geographic Information System (GIS), West Azerbaijan Province, Iran. ⁶¹	Amini M...Chavshin AR	31346533	2019
46	West Nile virus infections are here! Are we prepared to face another flavivirus epidemic? ⁶¹	Castro-Jorge LA...Fonseca BALD	30942263	2019
47	West Nile Virus Infection in Travelers Returning to United Kingdom from South Africa. ⁶¹	Parkash V...Cartwright K	30666938	2019
48	Effect of Serratia AS1 (Enterobacteriaceae: Enterobacteriales) on the Fitness of Culex pipiens (Diptera: Culicidae) for Paratransgenic and RNAi Approaches. ⁶¹	Koosha M...Oshaghi MA	30388221	2019
49	Quantitative Inventory of Mosquito Larvae (Diptera: Culicidae) and Physicochemical Analysis of Aquatic Habitats in the Region of Fez, Morocco. ⁶¹	Mouatassem TF...Lalami AEO	31478623	2019
50	West Nile virus (lineage 2) detected for the first time in mosquitoes in Southern Bohemia: new WNV endemic area? ⁶¹	Rudolf I...Sikutova S	31914781	2019

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Genes for West Nile Encephalitis

Genes related to West Nile Encephalitis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CHKA	Choline Kinase Alpha	Protein Coding	7.15	GeneCards inferred via : Publications (show sections)
2	OAS1	2'-5'-Oligoadenylate Synthetase 1	Protein Coding	5.63	DISEASES inferred ¹⁵
3	CD8A	CD8a Molecule	Protein Coding	5.5	DISEASES inferred ¹⁵
4	TLR7	Toll Like Receptor 7	Protein Coding	5.36	DISEASES inferred ¹⁵
5	CD4	CD4 Molecule	Protein Coding	5.26	DISEASES inferred ¹⁵
6	RNASEL	Ribonuclease L	Protein Coding	5.14	DISEASES inferred ¹⁵
7	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	5.07	DISEASES inferred ¹⁵
8	CLEC4M	C-Type Lectin Domain Family 4 Member M	Protein Coding	5.06	DISEASES inferred ¹⁵
9	TLR9	Toll Like Receptor 9	Protein Coding	5.06	DISEASES inferred ¹⁵
10	ITPA	Inosine Triphosphatase	Protein Coding	5.03	DISEASES inferred ¹⁵
11	OASL	2'-5'-Oligoadenylate Synthetase Like	Protein Coding	4.96	DISEASES inferred ¹⁵
12	TMEM214	Transmembrane Protein 214	Protein Coding	4.92	DISEASES inferred ¹⁵
13	OAS3	2'-5'-Oligoadenylate Synthetase 3	Protein Coding	4.84	DISEASES inferred ¹⁵

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Variations for West Nile Encephalitis

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Expression for West Nile Encephalitis

Search GEO for disease gene expression data for West Nile Encephalitis.

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Pathways for West Nile Encephalitis

Pathways related to West Nile Encephalitis according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.65	TLR9 TLR7 RNASEL OASL OAS3 OAS1
2	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.02	RNASEL OASL OAS3 OAS1 CD4 CCR5
3	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.8	TLR9 TLR7 RNASEL OAS3 OAS1
4	Herpes simplex virus 1 infection ³⁶	12.52	TLR9 RNASEL OAS3 OAS1
5	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.32	TLR9 CD8A CD4 CCR5
6	Interferon gamma signaling ⁶⁵ Show member pathways Interferon Signaling ⁶⁵ Regulation of IFNG signaling ⁶⁵	12.16	RNASEL OASL OAS3 OAS1
7	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.14	TLR9 TLR7 RNASEL OAS3 OAS1 CLEC4M
8	NF-kappaB Signaling ⁴	12.07	TLR9 TLR7 RNASEL OAS1 CD8A
9	NOD-like receptor signaling pathway ³⁶	11.97	RNASEL OAS3 OAS1
10	Immune response IFN alpha/beta signaling pathway ²³ Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	11.97	RNASEL OASL OAS3 OAS1
11	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²³	11.72	CD8A CD4 CCR5
12	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.46	TLR9 TLR7 CD4
13	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.31	TLR9 TLR7 CD4
14	Dendritic Cells Developmental Lineage Pathway ⁶⁴	10.79	TLR9 TLR7 CD8A CD4

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GO Terms for West Nile Encephalitis

Cellular components related to West Nile Encephalitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endolysosome membrane	GO:0036020	8.96	TLR9 TLR7
2	early phagosome	GO:0032009	8.62	TLR9 TLR7

Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	innate immune response	GO:0045087	9.85	TLR9 TLR7 OASL OAS3 OAS1 CLEC4M
2	immune response	GO:0006955	9.8	TLR9 TLR7 CD8A CD4 CCR5
3	response to virus	GO:0009615	9.67	OASL OAS3 OAS1
4	type I interferon signaling pathway	GO:0060337	9.62	RNASEL OASL OAS3 OAS1
5	interferon-gamma-mediated signaling pathway	GO:0060333	9.61	OASL OAS3 OAS1
6	negative regulation of viral genome replication	GO:0045071	9.56	RNASEL OASL OAS3 OAS1
7	immune system process	GO:0002376	9.56	TLR9 TLR7 OASL OAS3 OAS1 CLEC4M
8	positive regulation of interferon-alpha production	GO:0032727	9.52	TLR9 TLR7
9	toll-like receptor 9 signaling pathway	GO:0034162	9.51	TLR9 TLR7
10	I-kappaB phosphorylation	GO:0007252	9.48	TLR9 TLR7
11	fusion of virus membrane with host plasma membrane	GO:0019064	9.46	CD4 CCR5
12	regulation of ribonuclease activity	GO:0060700	9.33	OASL OAS3 OAS1
13	defense response to virus	GO:0051607	9.1	TLR9 TLR7 RNASEL OASL OAS3 OAS1

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleotidyltransferase activity	GO:0016779	9.5	OASL OAS3 OAS1
2	drug binding	GO:0008144	9.43	TLR7 CHKA
3	virus receptor activity	GO:0001618	9.43	CLEC4M CD4 CCR5
4	pattern recognition receptor activity	GO:0038187	9.4	TLR9 TLR7
5	siRNA binding	GO:0035197	9.37	TLR9 TLR7
6	coreceptor activity	GO:0015026	9.33	CD8A CD4 CCR5
7	double-stranded RNA binding	GO:0003725	9.26	TLR7 OASL OAS3 OAS1
8	2'-5'-oligoadenylate synthetase activity	GO:0001730	8.8	OASL OAS3 OAS1

Sources

Sources for West Nile Encephalitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

West Nile Encephalitis

Aliases & Classifications for West Nile Encephalitis

MalaCards integrated aliases for West Nile Encephalitis:

Classifications:

External Ids:

Summaries for West Nile Encephalitis

Related Diseases for West Nile Encephalitis

Diseases in the West Nile Encephalitis family:

Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to West Nile Encephalitis:

Symptoms & Phenotypes for West Nile Encephalitis

Symptoms:

MGI Mouse Phenotypes related to West Nile Encephalitis:

Drugs & Therapeutics for West Nile Encephalitis

Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 51 :

Cochrane evidence based reviews: west nile fever

Genetic Tests for West Nile Encephalitis

Anatomical Context for West Nile Encephalitis

MalaCards organs/tissues related to West Nile Encephalitis:

Publications for West Nile Encephalitis

Articles related to West Nile Encephalitis:

Genes for West Nile Encephalitis

Genes related to West Nile Encephalitis (0 elite genes):

Variations for West Nile Encephalitis

Expression for West Nile Encephalitis

Pathways for West Nile Encephalitis

Pathways related to West Nile Encephalitis according to GeneCards Suite gene sharing:

GO Terms for West Nile Encephalitis

Cellular components related to West Nile Encephalitis according to GeneCards Suite gene sharing:

Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

Sources for West Nile Encephalitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵¹ :