MCID: WST004
MIFTS: 42

West Nile Encephalitis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for West Nile Encephalitis

MalaCards integrated aliases for West Nile Encephalitis:

Name: West Nile Encephalitis 12 53 15
West Nile Fever 44 73
West Nile Fever with Encephalitis 12
Encephalitis, West Nile Fever 73
West Nile Fever Encephalitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2365
ICD10 33 A92.31
ICD9CM 35 066.41
MeSH 44 D014901
SNOMED-CT 68 392662004
UMLS 73 C0751583

Summaries for West Nile Encephalitis

NIH Rare Diseases : 53 West Nile encephalitis is a form of West Nile virus that affects the neurological system. Signs and symptoms may include headache, fever, neck stiffness, disorientation, tremors, seizures, paralysis, or coma. West Nile virus is generally spread to humans by infected mosquitos. West Nile encephalitis, specifically, occurs when the virus crosses the blood-brain barrier and infects the central nervous system. Although West Nile encephalitis can affect anyone, people who are over age 60, have received an organ transplant, or are affected by certain medical conditions such as cancer, diabetes, hypertension, and kidney disease have the highest risk of developing the condition. Treatment is supportive and hospitalization may be required to address the associated symptoms. Recovery may take several weeks or months and some of the neurologic effects may be permanent.

MalaCards based summary : West Nile Encephalitis, also known as west nile fever, is related to west nile fever and west nile virus, and has symptoms including high fever, headache and neck stiffness. An important gene associated with West Nile Encephalitis is TLR9 (Toll Like Receptor 9), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Influenza A. The drugs Ribavirin and Glycine have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and kidney.

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in West Nile virus, which is transmitted by Culex, transmitted by Aedes, and transmitted by Anopheles species of mosquitoes. The infection has symptom high fever, has symptom headache, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, has symptom muscle weakness, has symptom vision loss, has symptom numbness, and has symptom paralysis.

Related Diseases for West Nile Encephalitis

Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 west nile fever 12.7
2 west nile virus 11.7
3 kunjin encephalitis 11.3
4 encephalitis 10.8
5 neuronitis 10.0
6 meningitis 10.0
7 malaria 9.9
8 polyglucosan body myopathy 1 with or without immunodeficiency 9.9
9 japanese encephalitis 9.9
10 status epilepticus 9.9
11 myelitis 9.9
12 movement disease 9.9
13 pneumonia 9.9
14 lymphopenia 9.9
15 diabetes insipidus 9.9
16 opsoclonus-myoclonus syndrome 9.9
17 myoclonus 9.9
18 tick-borne encephalitis 9.8 OAS1 OAS3
19 yellow fever 9.7 OAS1 TLR9
20 microphthalmia with limb anomalies 9.7 OAS1 OAS3
21 chikungunya 9.3 BST2 OAS3
22 human immunodeficiency virus infectious disease 9.3 BST2 TLR9
23 viral infectious disease 9.3 OAS1 TLR9

Graphical network of the top 20 diseases related to West Nile Encephalitis:



Diseases related to West Nile Encephalitis

Symptoms & Phenotypes for West Nile Encephalitis

Symptoms:

12 (show all 12)
  • high fever
  • headache
  • neck stiffness
  • stupor
  • disorientation
  • coma
  • tremors
  • convulsions
  • muscle weakness
  • vision loss
  • numbness
  • paralysis

Drugs & Therapeutics for West Nile Encephalitis

Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
3 Anti-Infective Agents Phase 2
4 Antimetabolites Phase 2
5 Antiviral Agents Phase 2
6 Antibodies Phase 1, Phase 2,Phase 2
7 gamma-Globulins Phase 1, Phase 2,Phase 2
8 Immunoglobulin G Phase 1, Phase 2,Phase 2
9 Immunoglobulins Phase 1, Phase 2,Phase 2
10 Immunoglobulins, Intravenous Phase 1, Phase 2,Phase 2
11 Pharmaceutical Solutions Phase 1, Phase 2
12 Rho(D) Immune Globulin Phase 1, Phase 2,Phase 2
13 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Japanese Encephalitis Unknown status NCT00216268 Phase 2 Ribavirin
2 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
3 Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]
4 Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus Disease Completed NCT00069316 Phase 2 Omr-IgG-am
5 Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of Age Completed NCT02186626 Phase 1
6 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults Completed NCT00094718 Phase 1
7 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Completed NCT00537147 Phase 1
8 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection

Search NIH Clinical Center for West Nile Encephalitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: west nile fever

Genetic Tests for West Nile Encephalitis

Anatomical Context for West Nile Encephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to West Nile Encephalitis:

19
Brain

MalaCards organs/tissues related to West Nile Encephalitis:

41
Brain, Kidney, B Cells, Occipital Lobe, T Cells

Publications for West Nile Encephalitis

Articles related to West Nile Encephalitis:

(show top 50) (show all 64)
# Title Authors Year
1
West Nile Encephalitis in the Emergency Department: Prevalence and Recognition. ( 28712523 )
2017
2
A Case of West Nile Encephalitis That Develops into a Disease of Deep White Matter on MRI over a Two-Week Span. ( 27703823 )
2016
3
Outcomes of West Nile encephalitis patients after one year of West Nile encephalitis outbreak in Kerala, India: A follow-up study. ( 27061922 )
2016
4
West Nile Encephalitis and Its Characteristics in Childhood. ( 26199702 )
2015
5
The first reported case of West Nile encephalitis in Korea. ( 25729260 )
2015
6
Emergence of Equine West Nile Encephalitis in Central Macedonia, Greece, 2010. ( 25660661 )
2015
7
Manifestation of West Nile Encephalitis in Infancy. ( 26501475 )
2015
8
Three Cases of West Nile Encephalitis over an Eight-Day Period at a Downtown Los Angeles Community Hospital. ( 26106493 )
2015
9
C-65Neurocognitive Rehabilitation of a West Nile Encephalitis Survivor. ( 25176908 )
2014
10
Opsoclonus-myoclonus syndrome attributable to West Nile encephalitis: a case report. ( 24968889 )
2014
11
West Nile encephalitis outbreak in Kerala, India, 2011. ( 24985196 )
2014
12
The 2012 West Nile encephalitis epidemic in Dallas, Texas. ( 23860988 )
2013
13
An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibody. ( 23864620 )
2013
14
Are ESR/CRP ratios helpful in differentiating West Nile encephalitis from non-West Nile virus meningitis/encephalitis? ( 23427877 )
2013
15
Locally acquired West Nile encephalitis. ( 21865003 )
2012
16
IL-22 signaling contributes to West Nile encephalitis pathogenesis. ( 22952908 )
2012
17
West Nile encephalitis presenting with severe persistent chills mimicking malaria. ( 22297291 )
2011
18
OAS1 polymorphisms are associated with susceptibility to West Nile encephalitis in horses. ( 20479874 )
2010
19
Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent West Nile encephalitis. ( 20509624 )
2010
20
TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. ( 20660705 )
2010
21
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. ( 19200759 )
2009
22
The host immunologic response to West Nile encephalitis virus. ( 19273254 )
2009
23
Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. ( 19141700 )
2009
24
The relative contribution of antibody and CD8+ T cells to vaccine immunity against West Nile encephalitis virus. ( 18339459 )
2008
25
Rhabdomyolysis in a patient with West Nile encephalitis and flaccid paralysis. ( 18488686 )
2008
26
Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population. ( 18453596 )
2008
27
Efficacy and durability of a recombinant subunit West Nile vaccine candidate in protecting hamsters from West Nile encephalitis. ( 17067727 )
2007
28
West Nile encephalitis, status epilepticus and West Nile pneumonia in a renal transplant patient. ( 17630998 )
2007
29
West Nile encephalitis relapse presenting with abducens and facial nerve palsies. ( 16750946 )
2006
30
West Nile encephalitis mimicking herpes encephalitis. ( 16814089 )
2006
31
Opsoclonus persisting during sleep in West Nile encephalitis. ( 16966514 )
2006
32
Potentiation of West Nile encephalitis by mosquito feeding. ( 16553552 )
2006
33
Use of interferon-alpha in patients with West Nile encephalitis: report of 2 cases. ( 15714427 )
2005
34
Rhabdomyolysis in patients with west nile encephalitis and meningitis. ( 16187894 )
2005
35
Serum ferritin levels in West Nile encephalitis. ( 14759247 )
2004
36
West Nile encephalitis and myelitis. ( 15167070 )
2004
37
Differential diagnosis of West Nile encephalitis. ( 15353960 )
2004
38
The Israeli strain IS-98-ST1 of West Nile virus as viral model for West Nile encephalitis in the Old World. ( 15550172 )
2004
39
An occipital lobe epileptogenic focus in a patient with West Nile encephalitis. ( 14748771 )
2004
40
Central diabetes insipidus complicating West Nile encephalitis. ( 15034844 )
2004
41
Prognostic importance of lymphopenia in West Nile encephalitis. ( 15501215 )
2004
42
Listeria monocytogenes encephalitis mimicking West Nile encephalitis. ( 14983142 )
2004
43
Muscle weakness in West Nile encephalitis is due to destruction of motor neurons. ( 12827621 )
2003
44
Natural and nosocomial infection in a patient with West Nile encephalitis and extrapyramidal movement disorders. ( 12766856 )
2003
45
Innate and adaptive immune responses determine protection against disseminated infection by West Nile encephalitis virus. ( 14583143 )
2003
46
Infection and injury of neurons by West Nile encephalitis virus. ( 14645577 )
2003
47
West Nile encephalitis presenting as a stroke. ( 12572565 )
2003
48
B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus. ( 12551996 )
2003
49
West Nile encephalitis in Massachusetts. ( 11919319 )
2002
50
West Nile encephalitis. ( 12436096 )
2002

Variations for West Nile Encephalitis

Expression for West Nile Encephalitis

Search GEO for disease gene expression data for West Nile Encephalitis.

Pathways for West Nile Encephalitis

GO Terms for West Nile Encephalitis

Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.62 BST2 OAS1 OAS3 TLR9
2 immune system process GO:0002376 9.61 OAS1 OAS3 TLR9
3 defense response to virus GO:0051607 9.54 BST2 OAS1 OAS3
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.46 BST2 TLR9
5 response to virus GO:0009615 9.43 BST2 OAS1 OAS3
6 interferon-gamma-mediated signaling pathway GO:0060333 9.4 OAS1 OAS3
7 regulation of ribonuclease activity GO:0060700 9.16 OAS1 OAS3
8 type I interferon signaling pathway GO:0060337 9.13 BST2 OAS1 OAS3
9 negative regulation of viral genome replication GO:0045071 8.8 BST2 OAS1 OAS3

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotidyltransferase activity GO:0016779 9.16 OAS1 OAS3
2 double-stranded RNA binding GO:0003725 8.96 OAS1 OAS3
3 2-5-oligoadenylate synthetase activity GO:0001730 8.62 OAS1 OAS3

Sources for West Nile Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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