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MCID: WST004
MIFTS: 41

West Nile Encephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for West Nile Encephalitis

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MalaCards integrated aliases for West Nile Encephalitis:

Name: West Nile Encephalitis 12 52 15 17
West Nile Fever 43 71
West Nile Fever with Encephalitis 12
Encephalitis, West Nile Fever 71
West Nile Fever Encephalitis 12

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2365
ICD9CM 34 066.41
MeSH 43 D014901
ICD10 32 A92.31
UMLS 71 C0043124 C0751583
Sources

Summaries for West Nile Encephalitis

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NIH Rare Diseases : 52 West Nile encephalitis is a form of West Nile virus that affects the neurological system . Signs and symptoms may include headache, fever, neck stiffness, disorientation, tremors, seizures , paralysis, or coma. West Nile virus is generally spread to humans by infected mosquitos. West Nile encephalitis, specifically, occurs when the virus crosses the blood-brain barrier and infects the central nervous system . Although West Nile encephalitis can affect anyone, people who are over age 60, have received an organ transplant, or are affected by certain medical conditions such as cancer , diabetes, hypertension , and kidney disease have the highest risk of developing the condition. Treatment is supportive and hospitalization may be required to address the associated symptoms. Recovery may take several weeks or months and some of the neurologic effects may be permanent.

MalaCards based summary : West Nile Encephalitis, also known as west nile fever, is related to west nile virus and encephalitis. An important gene associated with West Nile Encephalitis is CHKA (Choline Kinase Alpha), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Ribavirin and Glycine have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and b cells, and related phenotype is immune system.

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in West Nile virus, which is transmitted by Culex, transmitted by Aedes, and transmitted by Anopheles species of mosquitoes. The infection has symptom high fever, has symptom headache, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, has symptom muscle weakness, has symptom vision loss, has symptom numbness, and has symptom paralysis.

Sources

Related Diseases for West Nile Encephalitis

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Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 314)
# Related Disease Score Top Affiliating Genes
1 west nile virus 33.2 OAS1 CLEC4M CCR5
2 encephalitis 31.7 CLEC4M CD40LG CCR5
3 meningoencephalitis 31.0 CD8A CD40LG CD4
4 optic papillitis 30.8 CD40LG CD4
5 poliomyelitis 30.6 CD8A CD40LG CD4
6 exanthem 30.6 CD8A CD40LG CD4
7 coccidioidomycosis 30.6 CD40LG CD4
8 orchitis 30.4 CD8A CD40LG CD4
9 viral encephalitis 30.4 CD8A CD40LG CD4
10 yellow fever 30.3 OAS1 CD8A CD40LG CCR5
11 chikungunya 30.2 TLR7 OAS3 OAS1
12 tick-borne encephalitis 30.2 OAS3 OAS1 CCR5
13 severe acute respiratory syndrome 30.2 CLEC4M CD40LG CCR5
14 dengue disease 29.9 RNASEL CLEC4M CD8A CD40LG
15 plague 29.7 INVS CD8A CD4 CCR5
16 leukemia, chronic lymphocytic 29.2 TLR7 CD8A CD40LG CD4 CCR5
17 west nile fever 29.0 RNASEL OASL OAS3 OAS1 CLEC4M CD8A
18 viral infectious disease 29.0 TLR7 RNASEL OAS1 CLEC4M CD40LG CD4
19 systemic lupus erythematosus 28.8 TLR7 OAS1 CD8A CD40LG CD4 CCR5
20 kunjin encephalitis 11.6
21 riedel's fibrosing thyroiditis 10.5 CD40LG CD4
22 ventilation pneumonitis 10.4 CD8A CD4
23 latent syphilis 10.4 CD40LG CD4
24 gastroduodenitis 10.4 CD40LG CD4
25 primary syphilis 10.4 CD40LG CD4
26 asymptomatic neurosyphilis 10.4 CD40LG CD4
27 tertiary neurosyphilis 10.4 CD40LG CD4
28 diffuse infiltrative lymphocytosis syndrome 10.4 CD8A CD4
29 transient arthritis 10.4 CD40LG CD4
30 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
31 neuroretinitis 10.4 CD40LG CD4
32 meningovascular neurosyphilis 10.4 CD40LG CD4
33 la crosse encephalitis 10.4 RNASEL CD40LG
34 chromosome 14q11-q22 deletion syndrome 10.4 CD8A CD4
35 diabetes mellitus, insulin-dependent, 23 10.4 CD8A CD4
36 bird fancier's lung 10.4 CD8A CD4
37 viral exanthem 10.4 CD40LG CD4
38 parapsoriasis 10.4 CD8A CD4
39 aseptic meningitis 10.4
40 cerebral lymphoma 10.4 CD40LG CD4
41 gastrointestinal tuberculosis 10.4 CD40LG CD4
42 metal allergy 10.4 CD8A CD4
43 ocular toxoplasmosis 10.4 CD40LG CCR5
44 variola major 10.4 CD8A CD4
45 selective immunoglobulin deficiency disease 10.4 CD8A CD40LG
46 follicular mucinosis 10.4 CD8A CD4
47 spongiotic dermatitis 10.4 CD8A CD4
48 nickel allergic contact dermatitis 10.4 CD8A CD4
49 congenital syphilis 10.4 CD40LG CD4
50 mononeuritis of upper limb and mononeuritis multiplex 10.4 CD40LG CD4

Graphical network of the top 20 diseases related to West Nile Encephalitis:



Diseases related to West Nile Encephalitis
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Symptoms & Phenotypes for West Nile Encephalitis

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MGI Mouse Phenotypes related to West Nile Encephalitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 CCR5 CD4 CD40LG CD8A CLEC4M INVS
Sources

Drugs & Therapeutics for West Nile Encephalitis

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Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
3 Antiviral Agents Phase 2
4 Antimetabolites Phase 2
5 Anti-Infective Agents Phase 2
6 Vaccines Phase 2
7 Immunologic Factors Phase 2
8 Pharmaceutical Solutions Phase 2
9 Immunoglobulin G Phase 2
10 Rho(D) Immune Globulin Phase 2
11 Immunoglobulins, Intravenous Phase 2
12 gamma-Globulins Phase 2
13 Antibodies, Monoclonal Phase 2
14 Immunoglobulins Phase 2
15 Antibodies Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Treatment of Japanese Encephalitis - a Double Blind Placebo Controlled Trial Unknown status NCT00216268 Phase 2 Ribavirin
2 Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults. Completed NCT00746798 Phase 2
3 Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
4 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (Omr-IgG-am) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus(WNV) Completed NCT00069316 Phase 2 Omr-IgG-am
5 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (OMR-IGG-AM) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus (WNV) Encephalitis and/or Myelitis Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
6 A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRelâ„¢ (batch 20081217)]
7 Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus Terminated NCT00927953 Phase 2
8 Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00094718 Phase 1
9 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00537147 Phase 1
10 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3´Î”30 Chimeric Virus Vaccine (WN/DEN4Δ30), a Live Attenuated Vaccine for West Nile Encephalitis, in Flavivirus-naïve Adults 50-65 Years of Age Completed NCT02186626 Phase 1
11 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
12 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
13 An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
14 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
15 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00138463
16 Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus No longer available NCT01206504

Search NIH Clinical Center for West Nile Encephalitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ribavirin

Cochrane evidence based reviews: west nile fever

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Genetic Tests for West Nile Encephalitis

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Anatomical Context for West Nile Encephalitis

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MalaCards organs/tissues related to West Nile Encephalitis:

40
Brain, Kidney, B Cells, Lung, T Cells, Lymph Node, Bone
Sources

Publications for West Nile Encephalitis

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Articles related to West Nile Encephalitis:

(show top 50) (show all 527)
# Title Authors PMID Year
1
Zoonotic Diseases in Oman: Successes, Challenges, and Future Directions. 61
31486732 2020
2
Development of an Internally Controlled Reverse Transcription Recombinase-aided Amplification Assay for the Rapid and Visual Detection of West Nile Virus. 61
31918798 2019
3
Emerging viruses in older population Chikungunya, West Nile fever and Dengue. 61
31741192 2019
4
Ecological Niche Modeling of West Nile Virus Vector in Northwest of Iran. 61
31745415 2019
5
Economic Burden of West Nile Virus Disease, Quebec, Canada, 2012-2013. 61
31538563 2019
6
Arboviral diseases in pediatrics. 61
31605670 2019
7
West Nile fever in Europe in 2018: an emerging problem or just an anomaly? 61
31562277 2019
8
Evidence of West Nile Virus (WNV) Circulation in Wild Birds and WNV RNA Negativity in Mosquitoes of the Danube Delta Biosphere Reserve, Romania, 2016. 61
31438608 2019
9
West Nile encephalitis mimicking neuropsychiatric lupus in a patient with systemic lupus erythematosus. 61
31345830 2019
10
Spectrum of Movement Disorders in Patients With Neuroinvasive West Nile Virus Infection. 61
31392241 2019
11
Cognitive behavioural impairment with irreversible sensorineural deafness as a complication of West Nile encephalitis. 61
30903400 2019
12
Emergent Arboviruses and Renal Transplantation: A Global Challenge. 61
31080919 2019
13
Flaviviruses and Kidney Diseases. 61
31202392 2019
14
Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions. 61
30967466 2019
15
Short Communication: West Nile fever imported from Austria to Germany. 61
30462884 2019
16
West Nile virus infections are here! Are we prepared to face another flavivirus epidemic? 61
30942263 2019
17
The Potential of West Nile Virus Transmission Regarding the Environmental Factors Using Geographic Information System (GIS), West Azerbaijan Province, Iran. 61
31346533 2019
18
West Nile Virus Infection in Travelers Returning to United Kingdom from South Africa. 61
30666938 2019
19
Effect of Serratia AS1 (Enterobacteriaceae: Enterobacteriales) on the Fitness of Culex pipiens (Diptera: Culicidae) for Paratransgenic and RNAi Approaches. 61
30388221 2019
20
Quantitative Inventory of Mosquito Larvae (Diptera: Culicidae) and Physicochemical Analysis of Aquatic Habitats in the Region of Fez, Morocco. 61
31478623 2019
21
West Nile virus (lineage 2) detected for the first time in mosquitoes in Southern Bohemia: new WNV endemic area? 61
31914781 2019
22
West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature. 61
31205637 2019
23
Phenotypic insecticide resistance in arbovirus mosquito vectors in Catalonia and its capital Barcelona (Spain). 61
31276554 2019
24
West Nile fever - autochthonous human cases in South Moravia in 2018 from the epidemiological perspective. 61
31914772 2019
25
Emergence and Associated Risk Factors of Vector Borne West Nile Virus Infection in Ilorin, Nigeria. 61
30918903 2018
26
Co-circulation dynamics and persistence of newly introduced clades of 2012 outbreak associated West Nile Virus in Texas, 2012-2015. 61
30153478 2018
27
[Mosquitoes and Ticks: The Influence of Global Warming in the Transmission of Infectious Diseases in Germany]. 61
30440075 2018
28
West Nile virus lineage 2 in Romania, 2015-2016: co-circulation and strain replacement. 61
30367671 2018
29
Increase in human West Nile and Usutu virus infections, Austria, 2018. 61
30376913 2018
30
Conglomeration of novel Culex quinquefasciatus salivary proteins to contrive multi-epitope subunit vaccine against infections caused by blood imbibing transmitter. 61
29953889 2018
31
Early start of the West Nile fever transmission season 2018 in Europe. 61
30107869 2018
32
Does intra-individual neurocognitive variability relate to neuroinvasive disease and quality of life in West Nile Virus? 61
29696579 2018
33
Epidemiology and ecology of West Nile virus in sub-Saharan Africa. 61
30005653 2018
34
Establishment and optimization of a liquid bead array for the simultaneous detection of ten insect-borne pathogens. 61
30064470 2018
35
Lethal disseminated dysembryoplastic neuroepithelial tumor following West Nile virus: Report of a very unusual combination. 61
29988761 2018
36
Morbidity, mortality and long-term sequelae of West Nile virus disease in Québec. 61
29587891 2018
37
microRNA profiles and functions in mosquitoes. 61
29718912 2018
38
[Human Genetic Predisposition to Diseases Caused by Viruses from Flaviviridae Family]. 61
29695688 2018
39
Integrated analysis of human-animal-vector surveillance: West Nile virus infections in Austria, 2015-2016. 61
29535293 2018
40
Predictive Modeling for West Nile Virus and Mosquito Surveillance in Lubbock, Texas. 61
31442123 2018
41
Vector-borne diseases and climate change: a European perspective. 61
29149298 2018
42
Newer Vaccines against Mosquito-borne Diseases. 61
28560654 2018
43
Are we prepared for emerging flaviviruses in Europe? Challenges for vaccination. 61
29053401 2018
44
The Dengue Virus Replication Complex: From RNA Replication to Protein-Protein Interactions to Evasion of Innate Immunity. 61
29845529 2018
45
West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia Patient. 61
30405921 2018
46
West Nile virus (lineage 2) in mosquitoes in southern Moravia - awaiting the first autochthonous human cases. 61
30157657 2018
47
Surveillance and Diagnosis of West Nile Virus in the Face of Flavivirus Cross-Reactivity. 61
30369916 2018
48
Zoonotic Viral Diseases of Equines and Their Impact on Human and Animal Health. 61
30288197 2018
49
West Nile virus in horses during the summer and autumn seasons of 2015 and 2016, Portugal. 61
29173592 2017
50
Potential impact of climate change on emerging vector-borne and other infections in the UK. 61
29219091 2017
Sources

Variations for West Nile Encephalitis

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Expression for West Nile Encephalitis

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Search GEO for disease gene expression data for West Nile Encephalitis.
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Pathways for West Nile Encephalitis

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Pathways related to West Nile Encephalitis according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.72 TLR7 RNASEL OASL OAS3 OAS1 CD8A
2
Cytokine Signaling in Immune system 65
Show member pathways
 12.81 RNASEL OASL OAS3 OAS1 CD40LG CD4
3
Measles 36
Show member pathways
 12.36 TLR7 RNASEL OAS3 OAS1 CLEC4M
4
T cell receptor signaling pathway 36
Show member pathways
 12.3 CD8A CD40LG CD4 CCR5
5
Interferon gamma signaling 65
Show member pathways
 12.16 RNASEL OASL OAS3 OAS1
6
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.91 RNASEL OASL OAS3 OAS1
7
Cell adhesion molecules (CAMs) 36
11.84 CD8A CD40LG CD4
8
IL12-mediated signaling events 1
Show member pathways
 11.66 CD8A CD4 CCR5
9
NF-kappaB Signaling 4
11.54 TLR7 RNASEL OAS1 CD8A CD40LG
10
Dendritic Cells Developmental Lineage Pathway 64
11.37 TLR7 CD8A CD4
11
Primary immunodeficiency 36
10.71 CD8A CD40LG CD4
Sources

GO Terms for West Nile Encephalitis

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Cellular components related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CD8A CD40LG CD4 CCR5

Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.85 TLR7 OASL OAS3 OAS1 CLEC4M
2 immune system process GO:0002376 9.85 TLR7 OAS3 OAS1 CLEC4M CD8A CD4
3 defense response to virus GO:0051607 9.72 TLR7 RNASEL OASL OAS3 OAS1
4 response to virus GO:0009615 9.67 OASL OAS3 OAS1
5 interferon-gamma-mediated signaling pathway GO:0060333 9.65 OASL OAS3 OAS1
6 type I interferon signaling pathway GO:0060337 9.56 RNASEL OASL OAS3 OAS1
7 negative regulation of viral genome replication GO:0045071 9.46 RNASEL OASL OAS3 OAS1
8 fusion of virus membrane with host plasma membrane GO:0019064 9.43 CD4 CCR5
9 entry into host cell GO:0030260 9.4 CD4 CCR5
10 immune response GO:0006955 9.23 TLR7 OASL OAS3 OAS1 CD8A CD40LG
11 regulation of ribonuclease activity GO:0060700 9.13 OASL OAS3 OAS1

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.43 CLEC4M CD4 CCR5
2 coreceptor activity GO:0015026 9.33 CD8A CD4 CCR5
3 double-stranded RNA binding GO:0003725 9.26 TLR7 OASL OAS3 OAS1
4 2'-5'-oligoadenylate synthetase activity GO:0001730 8.8 OASL OAS3 OAS1
Sources

Sources for West Nile Encephalitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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