MCID: WST004
MIFTS: 39

West Nile Encephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for West Nile Encephalitis

MalaCards integrated aliases for West Nile Encephalitis:

Name: West Nile Encephalitis 12 54 15 17
West Nile Fever 45 74
West Nile Fever with Encephalitis 12
Encephalitis, West Nile Fever 74
West Nile Fever Encephalitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2365
ICD9CM 36 066.41
MeSH 45 D014901
ICD10 34 A92.31

Summaries for West Nile Encephalitis

NIH Rare Diseases : 54 West Nile encephalitis is a form of West Nile virus that affects the neurological system. Signs and symptoms may include headache, fever, neck stiffness, disorientation, tremors, seizures, paralysis, or coma. West Nile virus is generally spread to humans by infected mosquitos. West Nile encephalitis, specifically, occurs when the virus crosses the blood-brain barrier and infects the central nervous system. Although West Nile encephalitis can affect anyone, people who are over age 60, have received an organ transplant, or are affected by certain medical conditions such as cancer, diabetes, hypertension, and kidney disease have the highest risk of developing the condition. Treatment is supportive and hospitalization may be required to address the associated symptoms. Recovery may take several weeks or months and some of the neurologic effects may be permanent.

MalaCards based summary : West Nile Encephalitis, also known as west nile fever, is related to chikungunya and west nile virus. An important gene associated with West Nile Encephalitis is OAS1 (2'-5'-Oligoadenylate Synthetase 1), and among its related pathways/superpathways are Immune response IFN alpha/beta signaling pathway and Interferon gamma signaling. The drugs Ribavirin and Glycine have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and b cells.

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in West Nile virus, which is transmitted by Culex, transmitted by Aedes, and transmitted by Anopheles species of mosquitoes. The infection has symptom high fever, has symptom headache, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, has symptom muscle weakness, has symptom vision loss, has symptom numbness, and has symptom paralysis.

Related Diseases for West Nile Encephalitis

Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 chikungunya 29.4 BST2 OAS3
2 west nile virus 11.9
3 kunjin encephalitis 11.5
4 encephalitis 10.9
5 lymphopenia 10.2
6 meningitis 10.2
7 rift valley fever 10.1
8 coccidioidomycosis 10.1
9 west nile fever 10.1
10 leukemia, chronic lymphocytic 2 10.0
11 leukemia, chronic lymphocytic 10.0
12 malaria 10.0
13 polyglucosan body myopathy 1 with or without immunodeficiency 10.0
14 leukemia 10.0
15 lymphocytic leukemia 10.0
16 japanese encephalitis 10.0
17 status epilepticus 10.0
18 myelitis 10.0
19 movement disease 10.0
20 pneumonia 10.0
21 diabetes insipidus 10.0
22 leukemia, b-cell, chronic 10.0
23 opsoclonus-myoclonus syndrome 10.0
24 myoclonus 10.0
25 stiff-person syndrome 10.0
26 acute pancreatitis 10.0
27 newcastle disease 10.0
28 pancreatitis 10.0
29 tremor 10.0
30 microphthalmia with limb anomalies 9.9 OAS1 OAS3
31 tick-borne encephalitis 9.9 OAS1 OAS3
32 strabismus 9.6 INVS MID2

Graphical network of the top 20 diseases related to West Nile Encephalitis:



Diseases related to West Nile Encephalitis

Symptoms & Phenotypes for West Nile Encephalitis

Drugs & Therapeutics for West Nile Encephalitis

Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
3 Antimetabolites Phase 2
4 Antiviral Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Pharmaceutical Solutions Phase 1, Phase 2,Phase 2
7 Immunologic Factors Phase 1, Phase 2,Phase 2
8 Antibodies Phase 1, Phase 2,Phase 2
9 Immunoglobulin G Phase 1, Phase 2,Phase 2
10 Immunoglobulins, Intravenous Phase 1, Phase 2,Phase 2
11 Rho(D) Immune Globulin Phase 1, Phase 2,Phase 2
12 Immunoglobulins Phase 1, Phase 2,Phase 2
13 gamma-Globulins Phase 1, Phase 2,Phase 2
14 Vaccines Phase 2,Phase 1
15 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Treatment of Japanese Encephalitis Unknown status NCT00216268 Phase 2 Ribavirin
2 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
3 Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]
4 Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus Disease Completed NCT00069316 Phase 2 Omr-IgG-am
5 Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults Completed NCT00746798 Phase 2
6 Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
7 Treatment of West Nile Virus With MGAWN1 Terminated NCT00927953 Phase 2
8 Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of Age Completed NCT02186626 Phase 1
9 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults Completed NCT00094718 Phase 1
10 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Completed NCT00537147 Phase 1
11 Phase I Study of West Nile Virus Vaccine Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
12 Vaccine to Prevent West Nile Virus Disease Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
13 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
14 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
15 Natural History of West Nile Virus Infection Completed NCT00069303
16 West Nile Virus Natural History Completed NCT00138463
17 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
18 Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure No longer available NCT01206504

Search NIH Clinical Center for West Nile Encephalitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: west nile fever

Genetic Tests for West Nile Encephalitis

Anatomical Context for West Nile Encephalitis

MalaCards organs/tissues related to West Nile Encephalitis:

42
Brain, Kidney, B Cells, Lymph Node, T Cells, Occipital Lobe

Publications for West Nile Encephalitis

Articles related to West Nile Encephalitis:

(show top 50) (show all 139)
# Title Authors Year
1
Cognitive behavioural impairment with irreversible sensorineural deafness as a complication of West Nile encephalitis. ( 30903400 )
2019
2
Short Communication: West Nile fever imported from Austria to Germany. ( 30462884 )
2019
3
West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia Patient. ( 30405921 )
2018
4
Early start of the West Nile fever transmission season 2018 in Europe. ( 30107869 )
2018
5
West Nile Encephalitis in the Emergency Department: Prevalence and Recognition. ( 28712523 )
2017
6
Improved reliability of serological tools for the diagnosis of West Nile fever in horses within Europe. ( 28915240 )
2017
7
Emergence of Equine West Nile Encephalitis in Central Macedonia, Greece, 2010. ( 25660661 )
2016
8
A Case of West Nile Encephalitis That Develops into a Disease of Deep White Matter on MRI over a Two-Week Span. ( 27703823 )
2016
9
Outcomes of West Nile encephalitis patients after 1 year of West Nile encephalitis outbreak in Kerala, India: A follow-up study. ( 27061922 )
2016
10
Newcastle disease virus-vectored West Nile fever vaccine is immunogenic in mammals and poultry. ( 27342050 )
2016
11
Clinical Sentinel Surveillance of Equine West Nile Fever, Spain. ( 24899369 )
2016
12
Manifestation of West Nile Encephalitis in Infancy. ( 26501475 )
2015
13
Three Cases of West Nile Encephalitis over an Eight-Day Period at a Downtown Los Angeles Community Hospital. ( 26106493 )
2015
14
West Nile Encephalitis and Its Characteristics in Childhood. ( 26199702 )
2015
15
Outbreaks of West Nile fever in France. ( 26405120 )
2015
16
WEST NILE FEVER IN BRAZIL: SPORADIC CASE, SILENT ENDEMIC DISEASE OR EPIDEMIC IN ITS INITIAL STAGES? ( 26200972 )
2015
17
ECDC publishes new interactive online tool: West Nile fever maps for 2015. ( 26062647 )
2015
18
The first reported case of West Nile encephalitis in Korea. ( 25729260 )
2015
19
Mapping the serological prevalence rate of West Nile fever in equids, Tunisia. ( 23906318 )
2015
20
Human and entomological surveillance of West Nile fever, dengue and chikungunya in Veneto Region, Italy, 2010-2012. ( 24499011 )
2014
21
Opsoclonus-myoclonus syndrome attributable to West Nile encephalitis: a case report. ( 24968889 )
2014
22
Environmental predictors of West Nile fever risk in Europe. ( 24986363 )
2014
23
West Nile encephalitis outbreak in Kerala, India, 2011. ( 24985196 )
2014
24
West Nile fever in Israel: the reemergence of an endemic disease. ( 24183889 )
2014
25
An inactivated cell culture Japanese encephalitis vaccine (JE-ADVAX) formulated with delta inulin adjuvant provides robust heterologous protection against West Nile encephalitis via cross-protective memory B cells and neutralizing antibody. ( 23864620 )
2013
26
Environmental drivers of West Nile fever epidemiology in Europe and Western Asia--a review. ( 23939389 )
2013
27
The 2012 West Nile encephalitis epidemic in Dallas, Texas. ( 23860988 )
2013
28
Permissive summer temperatures of the 2010 European West Nile fever upsurge. ( 23431374 )
2013
29
Are ESR/CRP ratios helpful in differentiating West Nile encephalitis from non-West Nile virus meningitis/encephalitis? ( 23427877 )
2013
30
Can horses be clinically screened for West Nile Fever? ( 23292842 )
2013
31
IL-22 signaling contributes to West Nile encephalitis pathogenesis. ( 22952908 )
2012
32
Animal viral diseases and global change: bluetongue and West Nile fever as paradigms. ( 22707955 )
2012
33
Locally acquired West Nile encephalitis. ( 21865003 )
2012
34
Temporal distribution and spatial pattern of abundance of the Rift Valley fever and West Nile fever vectors in Barkedji, Senegal. ( 22129415 )
2011
35
West Nile encephalitis presenting with severe persistent chills mimicking malaria. ( 22297291 )
2011
36
West Nile fever outbreak in horses and humans, Spain, 2010. ( 22172565 )
2011
37
Clinical diagnosis of West Nile Fever in Equids by classification and regression tree (CART) analysis and comparative study of clinical appearance in three European countries. ( 21208395 )
2011
38
Primary causes of death in reported cases of fatal West Nile Fever, United States, 2002-2006. ( 20687860 )
2011
39
Differential West Nile fever ascertainment in the United States: a multilevel analysis. ( 20889867 )
2010
40
West Nile fever characteristics among viremic persons identified through blood donor screening. ( 20874087 )
2010
41
TLR9-targeted biodegradable nanoparticles as immunization vectors protect against West Nile encephalitis. ( 20660705 )
2010
42
Evaluation of the efficiency of bird-baited traps for sampling potential West Nile fever mosquito vectors (Diptera: Culicidae) in Senegal. ( 20597441 )
2010
43
Conjugation to nickel-chelating nanolipoprotein particles increases the potency and efficacy of subunit vaccines to prevent West Nile encephalitis. ( 20509624 )
2010
44
OAS1 polymorphisms are associated with susceptibility to West Nile encephalitis in horses. ( 20479874 )
2010
45
Where is West Nile fever? Lessons learnt from recent human cases in northern Italy. ( 19317987 )
2009
46
The host immunologic response to West Nile encephalitis virus. ( 19273254 )
2009
47
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. ( 19200759 )
2009
48
Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. ( 19141700 )
2009
49
Mosquito vectors of West Nile Fever in Israel. ( 18826039 )
2008
50
West Nile fever in a patient in Romania, August 2008: case report. ( 18822244 )
2008

Variations for West Nile Encephalitis

Expression for West Nile Encephalitis

Search GEO for disease gene expression data for West Nile Encephalitis.

Pathways for West Nile Encephalitis

Pathways related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.34 BST2 OAS1 OAS3
2
Show member pathways
11.29 BST2 OAS1 OAS3

GO Terms for West Nile Encephalitis

Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.62 BST2 MID2 OAS1 OAS3
2 defense response to virus GO:0051607 9.54 BST2 OAS1 OAS3
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.43 BST2 MID2
4 response to virus GO:0009615 9.43 BST2 OAS1 OAS3
5 interferon-gamma-mediated signaling pathway GO:0060333 9.4 OAS1 OAS3
6 regulation of ribonuclease activity GO:0060700 9.16 OAS1 OAS3
7 type I interferon signaling pathway GO:0060337 9.13 BST2 OAS1 OAS3
8 negative regulation of viral genome replication GO:0045071 8.8 BST2 OAS1 OAS3

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotidyltransferase activity GO:0016779 9.16 OAS1 OAS3
2 double-stranded RNA binding GO:0003725 8.96 OAS1 OAS3
3 2'-5'-oligoadenylate synthetase activity GO:0001730 8.62 OAS1 OAS3

Sources for West Nile Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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