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MCID: WST004
MIFTS: 38

West Nile Encephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for West Nile Encephalitis

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MalaCards integrated aliases for West Nile Encephalitis:

Name: West Nile Encephalitis 12 53 15 17
West Nile Fever 44 72
West Nile Fever with Encephalitis 12
Encephalitis, West Nile Fever 72
West Nile Fever Encephalitis 12

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2365
ICD9CM 35 066.41
MeSH 44 D014901
ICD10 33 A92.31
UMLS 72 C0043124 C0751583
Sources

Summaries for West Nile Encephalitis

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NIH Rare Diseases : 53 West Nile encephalitis is a form of West Nile virus that affects the neurological system. Signs and symptoms may include headache, fever, neck stiffness, disorientation, tremors, seizures, paralysis, or coma. West Nile virus is generally spread to humans by infected mosquitos. West Nile encephalitis, specifically, occurs when the virus crosses the blood-brain barrier and infects the central nervous system. Although West Nile encephalitis can affect anyone, people who are over age 60, have received an organ transplant, or are affected by certain medical conditions such as cancer, diabetes, hypertension, and kidney disease have the highest risk of developing the condition. Treatment is supportive and hospitalization may be required to address the associated symptoms. Recovery may take several weeks or months and some of the neurologic effects may be permanent.

MalaCards based summary : West Nile Encephalitis, also known as west nile fever, is related to viral infectious disease and tick-borne encephalitis. An important gene associated with West Nile Encephalitis is OAS1 (2'-5'-Oligoadenylate Synthetase 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Toll-like Receptor Signaling Pathway. The drugs Ribavirin and Glycine have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and testes.

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in West Nile virus, which is transmitted by Culex, transmitted by Aedes, and transmitted by Anopheles species of mosquitoes. The infection has symptom high fever, has symptom headache, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, has symptom muscle weakness, has symptom vision loss, has symptom numbness, and has symptom paralysis.

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Related Diseases for West Nile Encephalitis

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Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 viral infectious disease 30.2 RNASEL OAS1
2 tick-borne encephalitis 30.0 OAS3 OAS1
3 chikungunya 29.8 OAS3 BST2
4 west nile virus 12.0
5 kunjin encephalitis 11.6
6 encephalitis 11.0
7 meningoencephalitis 10.4
8 aseptic meningitis 10.4
9 west nile fever 10.4
10 japanese encephalitis 10.4
11 lymphopenia 10.3
12 meningitis 10.3
13 rift valley fever 10.2
14 coccidioidomycosis 10.2
15 ataxia and polyneuropathy, adult-onset 10.2
16 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.2
17 exanthem 10.2
18 viral meningitis 10.2
19 myelitis 10.2
20 poliomyelitis 10.2
21 yellow fever 10.2
22 opsoclonus-myoclonus syndrome 10.2
23 encephalopathy 10.2
24 meningitis and encephalitis 10.2
25 myoclonus 10.2
26 tremor 10.2
27 myocarditis 10.1
28 optic papillitis 10.1
29 arbovirosis 10.1
30 leukemia, chronic lymphocytic 10.0
31 systemic lupus erythematosus 10.0
32 neutrophil migration 10.0
33 spinal arachnoiditis 10.0
34 triiodothyronine receptor auxiliary protein 10.0
35 stroke, ischemic 10.0
36 branchiootic syndrome 1 10.0
37 malaria 10.0
38 angiosarcoma 10.0
39 lymphocytic leukemia 10.0
40 st. louis encephalitis 10.0
41 hydrocephalus 10.0
42 visual epilepsy 10.0
43 arachnoiditis 10.0
44 neutropenia 10.0
45 communicating hydrocephalus 10.0
46 thrombocytopenia 10.0
47 status epilepticus 10.0
48 orchitis 10.0
49 acute pancreatitis 10.0
50 central nervous system disease 10.0

Graphical network of the top 20 diseases related to West Nile Encephalitis:



Diseases related to West Nile Encephalitis
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Symptoms & Phenotypes for West Nile Encephalitis

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Drugs & Therapeutics for West Nile Encephalitis

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Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ribavirin Approved Phase 2 36791-04-5 37542
2
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
3 Antiviral Agents Phase 2
4 Antimetabolites Phase 2
5 Anti-Infective Agents Phase 2
6 Immunologic Factors Phase 2
7 Vaccines Phase 2
8 Pharmaceutical Solutions Phase 2
9 Immunoglobulin G Phase 2
10 gamma-Globulins Phase 2
11 Immunoglobulins, Intravenous Phase 2
12 Rho(D) Immune Globulin Phase 2
13 Antibodies Phase 2
14 Immunoglobulins Phase 2
15 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Treatment of Japanese Encephalitis - a Double Blind Placebo Controlled Trial Unknown status NCT00216268 Phase 2 Ribavirin
2 Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults. Completed NCT00746798 Phase 2
3 Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
4 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (Omr-IgG-am) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus(WNV) Completed NCT00069316 Phase 2 Omr-IgG-am
5 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (OMR-IGG-AM) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus (WNV) Encephalitis and/or Myelitis Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
6 A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]
7 Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus Terminated NCT00927953 Phase 2
8 Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00094718 Phase 1
9 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00537147 Phase 1
10 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3´Δ30 Chimeric Virus Vaccine (WN/DEN4Δ30), a Live Attenuated Vaccine for West Nile Encephalitis, in Flavivirus-naïve Adults 50-65 Years of Age Completed NCT02186626 Phase 1
11 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
12 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
13 An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
14 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
15 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00138463
16 Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus No longer available NCT01206504

Search NIH Clinical Center for West Nile Encephalitis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Ribavirin

Cochrane evidence based reviews: west nile fever

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Genetic Tests for West Nile Encephalitis

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Anatomical Context for West Nile Encephalitis

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MalaCards organs/tissues related to West Nile Encephalitis:

41
Brain, Kidney, Testes, B Cells, Lung, T Cells, Lymph Node
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Publications for West Nile Encephalitis

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Articles related to West Nile Encephalitis:

(show top 50) (show all 515)
# Title Authors PMID Year
1
West Nile encephalitis mimicking neuropsychiatric lupus in a patient with systemic lupus erythematosus. 38
31345830 2019
2
Spectrum of Movement Disorders in Patients With Neuroinvasive West Nile Virus Infection. 38
31392241 2019
3
Cognitive behavioural impairment with irreversible sensorineural deafness as a complication of West Nile encephalitis. 38
30903400 2019
4
Flaviviruses and Kidney Diseases. 38
31202392 2019
5
Emergent Arboviruses and Renal Transplantation: A Global Challenge. 38
31080919 2019
6
Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions. 38
30967466 2019
7
Short Communication: West Nile fever imported from Austria to Germany. 38
30462884 2019
8
West Nile virus infections are here! Are we prepared to face another flavivirus epidemic? 38
30942263 2019
9
The Potential of West Nile Virus Transmission Regarding the Environmental Factors Using Geographic Information System (GIS), West Azerbaijan Province, Iran. 38
31346533 2019
10
West Nile Virus Infection in Travelers Returning to United Kingdom from South Africa. 38
30666938 2019
11
Effect of Serratia AS1 (Enterobacteriaceae: Enterobacteriales) on the Fitness of Culex pipiens (Diptera: Culicidae) for Paratransgenic and RNAi Approaches. 38
30388221 2019
12
West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature. 38
31205637 2019
13
Phenotypic insecticide resistance in arbovirus mosquito vectors in Catalonia and its capital Barcelona (Spain). 38
31276554 2019
14
Co-circulation dynamics and persistence of newly introduced clades of 2012 outbreak associated West Nile Virus in Texas, 2012-2015. 38
30153478 2018
15
Emergence and Associated Risk Factors of Vector Borne West Nile Virus Infection in Ilorin, Nigeria. 38
30918903 2018
16
[Mosquitoes and Ticks: The Influence of Global Warming in the Transmission of Infectious Diseases in Germany]. 38
30440075 2018
17
West Nile virus lineage 2 in Romania, 2015-2016: co-circulation and strain replacement. 38
30367671 2018
18
Increase in human West Nile and Usutu virus infections, Austria, 2018. 38
30376913 2018
19
Conglomeration of novel Culex quinquefasciatus salivary proteins to contrive multi-epitope subunit vaccine against infections caused by blood imbibing transmitter. 38
29953889 2018
20
Early start of the West Nile fever transmission season 2018 in Europe. 38
30107869 2018
21
Does intra-individual neurocognitive variability relate to neuroinvasive disease and quality of life in West Nile Virus? 38
29696579 2018
22
Epidemiology and ecology of West Nile virus in sub-Saharan Africa. 38
30005653 2018
23
Establishment and optimization of a liquid bead array for the simultaneous detection of ten insect-borne pathogens. 38
30064470 2018
24
Lethal disseminated dysembryoplastic neuroepithelial tumor following West Nile virus: Report of a very unusual combination. 38
29988761 2018
25
Morbidity, mortality and long-term sequelae of West Nile virus disease in Québec. 38
29587891 2018
26
microRNA profiles and functions in mosquitoes. 38
29718912 2018
27
[Human Genetic Predisposition to Diseases Caused by Viruses from Flaviviridae Family]. 38
29695688 2018
28
Integrated analysis of human-animal-vector surveillance: West Nile virus infections in Austria, 2015-2016. 38
29535293 2018
29
Vector-borne diseases and climate change: a European perspective. 38
29149298 2018
30
Newer Vaccines against Mosquito-borne Diseases. 38
28560654 2018
31
Are we prepared for emerging flaviviruses in Europe? Challenges for vaccination. 38
29053401 2018
32
The Dengue Virus Replication Complex: From RNA Replication to Protein-Protein Interactions to Evasion of Innate Immunity. 38
29845529 2018
33
West Nile Encephalitis, an Unusual Infection in a Chronic Lymphocytic Leukemia Patient. 38
30405921 2018
34
West Nile virus (lineage 2) in mosquitoes in southern Moravia - awaiting the first autochthonous human cases. 38
30157657 2018
35
Surveillance and Diagnosis of West Nile Virus in the Face of Flavivirus Cross-Reactivity. 38
30369916 2018
36
Zoonotic Viral Diseases of Equines and Their Impact on Human and Animal Health. 38
30288197 2018
37
West Nile virus in horses during the summer and autumn seasons of 2015 and 2016, Portugal. 38
29173592 2017
38
Potential impact of climate change on emerging vector-borne and other infections in the UK. 38
29219091 2017
39
West Nile Encephalitis in the Emergency Department: Prevalence and Recognition. 38
28712523 2017
40
Serosurvey Reveals Exposure to West Nile Virus in Asymptomatic Horse Populations in Central Spain Prior to Recent Disease Foci. 38
27156847 2017
41
Epidemiologic and clinical parameters of West Nile virus infections in humans: a scoping review. 38
28877682 2017
42
Genetic Profiling and Comorbidities of Zika Infection. 38
28934431 2017
43
Improved reliability of serological tools for the diagnosis of West Nile fever in horses within Europe. 38
28915240 2017
44
Emerging arboviral human diseases in Southern Europe. 38
28252204 2017
45
Microbiological Zoonotic Emerging Risks, Transmitted Between Livestock Animals and Humans (2007-2015). 38
28670863 2017
46
Mosquito Biting Modulates Skin Response to Virus Infection. 38
28495485 2017
47
West Nile Virus: Seroprevalence in Animals in Palestine and Israel. 38
28628400 2017
48
Vertebrate Reservoirs of Arboviruses: Myth, Synonym of Amplifier, or Reality? 38
28703771 2017
49
A New Clade of Insect-Specific Flaviviruses from Australian Anopheles Mosquitoes Displays Species-Specific Host Restriction. 38
28713857 2017
50
Risk mapping of West Nile virus circulation in Spain, 2015. 38
28212847 2017
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Variations for West Nile Encephalitis

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Expression for West Nile Encephalitis

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Search GEO for disease gene expression data for West Nile Encephalitis.
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Pathways for West Nile Encephalitis

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Pathways related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 66
Show member pathways
 12.57 RNASEL OAS3 OAS1 BST2
2
Toll-like Receptor Signaling Pathway 37 1
Show member pathways
 12.37 RNASEL OAS3 OAS1
3
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 11.47 RNASEL OAS3 OAS1 BST2
4
Interferon gamma signaling 66
Show member pathways
 11.42 RNASEL OAS3 OAS1 BST2
Sources

GO Terms for West Nile Encephalitis

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Cellular components related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.1 RNASEL OAS3 OAS1 MID2 INVS BST2

Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.67 OAS3 OAS1 MID2 BST2
2 response to virus GO:0009615 9.5 OAS3 OAS1 BST2
3 defense response to virus GO:0051607 9.46 RNASEL OAS3 OAS1 BST2
4 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.43 MID2 BST2
5 interferon-gamma-mediated signaling pathway GO:0060333 9.4 OAS3 OAS1
6 regulation of ribonuclease activity GO:0060700 9.26 OAS3 OAS1
7 type I interferon signaling pathway GO:0060337 9.26 RNASEL OAS3 OAS1 BST2
8 negative regulation of viral genome replication GO:0045071 8.92 RNASEL OAS3 OAS1 BST2

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.46 RNASEL OAS3 OAS1 BST2
2 nucleotidyltransferase activity GO:0016779 9.26 OAS3 OAS1
3 double-stranded RNA binding GO:0003725 8.96 OAS3 OAS1
4 2'-5'-oligoadenylate synthetase activity GO:0001730 8.62 OAS3 OAS1
Sources

Sources for West Nile Encephalitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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