MCID: WST004
MIFTS: 44

West Nile Encephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for West Nile Encephalitis

MalaCards integrated aliases for West Nile Encephalitis:

Name: West Nile Encephalitis 12 15 17
West Nile Fever 44 71
West Nile Fever with Encephalitis 12
Encephalitis, West Nile Fever 71
West Nile Fever Encephalitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2365
ICD9CM 34 066.41
MeSH 44 D014901
SNOMED-CT 67 392662004
ICD10 32 A92.31
UMLS 71 C0043124 C0751583

Summaries for West Nile Encephalitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain, has material basis in West Nile virus, which is transmitted by Culex, transmitted by Aedes, and transmitted by Anopheles species of mosquitoes. The infection has symptom high fever, has symptom headache, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, has symptom muscle weakness, has symptom vision loss, has symptom numbness, and has symptom paralysis.

MalaCards based summary : West Nile Encephalitis, also known as west nile fever, is related to west nile virus and bell's palsy, and has symptoms including muscle weakness, headache and coma. An important gene associated with West Nile Encephalitis is CHKA (Choline Kinase Alpha), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include kidney, b cells and lymph node, and related phenotypes are hematopoietic system and mortality/aging

Related Diseases for West Nile Encephalitis

Diseases in the West Nile Encephalitis family:

West Nile Virus Encephalitis

Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
# Related Disease Score Top Affiliating Genes
1 west nile virus 32.5 OAS1 CLEC4M CCR5
2 bell's palsy 30.5 CD8A CD4
3 chikungunya 30.5 TLR7 OAS3 OAS1
4 orchitis 30.4 CD8A CD4
5 west nile virus infection 30.4 RNASEL OASL OAS1 CCR5
6 plague 30.2 CD8A CD4 CCR5
7 tick-borne encephalitis 30.1 OAS3 OAS1 CCR5
8 viral infectious disease 29.5 TLR9 TLR7 RNASEL OAS1 CLEC4M CD4
9 systemic lupus erythematosus 29.1 TLR9 TLR7 OASL OAS1 CD4 CCR5
10 west nile fever 29.1 RNASEL OASL OAS3 OAS1 CLEC4M CD8A
11 west nile virus encephalitis 11.6
12 kunjin encephalitis 11.3
13 encephalitis 11.0
14 meningoencephalitis 10.4
15 aseptic meningitis 10.4
16 japanese encephalitis 10.4
17 cork-handlers' disease 10.3 CD8A CD4
18 necrotic uveal melanoma 10.3 CD8A CD4
19 lymphopenia 10.3
20 early yaws 10.3 CD8A CD4
21 ventilation pneumonitis 10.3 CD8A CD4
22 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
23 latent syphilis 10.3 CD8A CD4
24 type 1 diabetes mellitus 23 10.3 CD8A CD4
25 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
26 parapsoriasis 10.3 CD8A CD4
27 gastroduodenitis 10.3 CD8A CD4
28 duodenitis 10.3 CD8A CD4
29 primary syphilis 10.3 CD8A CD4
30 norwegian scabies 10.3 CD8A CD4
31 bird fancier's lung 10.3 CD8A CD4
32 skin sarcoidosis 10.3 CD8A CD4
33 metal allergy 10.3 CD8A CD4
34 variola major 10.3 CD8A CD4
35 follicular mucinosis 10.3 CD8A CD4
36 tertiary syphilis 10.3 CD8A CD4
37 spongiotic dermatitis 10.3 CD8A CD4
38 acute retinal necrosis syndrome 10.3 CD8A CD4
39 cerebral lymphoma 10.3 CD8A CD4
40 oral tuberculosis 10.3 CD8A CD4
41 cerebritis 10.3 CD8A CD4
42 rift valley fever 10.3
43 coccidioidomycosis 10.3
44 invasive malignant thymoma 10.3 CD8A CD4
45 granulomatous hepatitis 10.3 CD8A CD4
46 exanthema subitum 10.3 CD8A CD4
47 immunodeficiency 36 10.3 CD8A CD4
48 viral exanthem 10.3 CD8A CD4
49 glanders 10.3 CD8A CD4
50 oral hairy leukoplakia 10.3 CD8A CD4

Graphical network of the top 20 diseases related to West Nile Encephalitis:



Diseases related to West Nile Encephalitis

Symptoms & Phenotypes for West Nile Encephalitis

Symptoms:

12 (show all 12)
  • muscle weakness
  • headache
  • coma
  • paralysis
  • numbness
  • vision loss
  • tremors
  • disorientation
  • convulsions
  • neck stiffness
  • high fever
  • stupor

MGI Mouse Phenotypes related to West Nile Encephalitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.61 CCR5 CD4 CD8A CLEC4M ITPA OASL
2 mortality/aging MP:0010768 9.32 CCR5 CD4 CD8A CHKA CLEC4M ITPA

Drugs & Therapeutics for West Nile Encephalitis

Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Pharmaceutical Solutions Phase 2
3 Immunologic Factors Phase 2
4 Immunoglobulins Phase 2
5 Antibodies Phase 2
6 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
2 Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults. Completed NCT00746798 Phase 2
3 Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus Terminated NCT00927953 Phase 2
4 Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00094718 Phase 1
5 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00537147 Phase 1
6 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
7 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
8 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3´Δ30 Chimeric Virus Vaccine (WN/DEN4Δ30), a Live Attenuated Vaccine for West Nile Encephalitis, in Flavivirus-naïve Adults 50-65 Years of Age Completed NCT02186626 Phase 1
9 An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
10 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
11 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00138463
12 Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus No longer available NCT01206504
13 Prospective Investigation of Oxidative Stress in West Nile Virus Infection Withdrawn NCT04371003

Search NIH Clinical Center for West Nile Encephalitis

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Ribavirin

Cochrane evidence based reviews: west nile fever

Genetic Tests for West Nile Encephalitis

Anatomical Context for West Nile Encephalitis

MalaCards organs/tissues related to West Nile Encephalitis:

40
Kidney, B Cells, Lymph Node, Pancreas, Skin, T Cells, Occipital Lobe

Publications for West Nile Encephalitis

Articles related to West Nile Encephalitis:

(show top 50) (show all 560)
# Title Authors PMID Year
1
Arboviruses in the Astrakhan region of Russia for 2018 season: The development of multiplex PCR assays and analysis of mosquitoes, ticks, and human blood sera. 61
33421655 2021
2
Current Status and a Perspective of Mosquito-Borne Diseases in the Republic of Korea. 61
33136531 2021
3
Predicting the spatio-temporal spread of West Nile virus in Europe. 61
33411739 2021
4
Sero-prevalence of West Nile virus and Rift Valley fever virus infections among cattle under extensive production system in South Omo area, southern Ethiopia. 61
33415465 2021
5
Environmental drivers, climate change and emergent diseases transmitted by mosquitoes and their vectors in southern Europe: A systematic review. 61
32810503 2020
6
West Nile Fever - Clinical and Epidemiological Characteristics. Review of the Literature and Contribution with Three Clinical Cases. 61
33415935 2020
7
The Roles of Osteopontin in the Pathogenesis of West Nile Encephalitis. 61
33317005 2020
8
[Emerging vectorial diseases: West Nile fever, Bluetongue and Schmallenberg]. 61
33012789 2020
9
Molecular Characterisation of Cytochrome Oxidase I and Internal Transcribed Spacer 2 Fragments of Culiseta longiareolata. 61
33269558 2020
10
Dengue Virus Strikes Back: Increased Future Risk of Severe Dengue Disease in Humans as a Result of Previous Exposure to Zika Virus. 61
33339098 2020
11
Autochthonous West Nile virus infection outbreak in humans, Leipzig, Germany, August to September 2020. 61
33213686 2020
12
Modeling the West Nile virus transfusion transmission risk in a nonoutbreak country associated with traveling donors. 61
32869276 2020
13
New onset of Bell's palsy in a patient with West Nile Encephalitis. 61
33088514 2020
14
Emerging Natural Focal Infectious Diseases in Russia: A Medical-Geographical Study. 61
33143199 2020
15
Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses. 61
32763313 2020
16
Investigation of Vector-Borne Viruses in Ticks, Mosquitos, and Ruminants in the Thrace District of Turkey. 61
32397953 2020
17
Pathogenicity of West Nile Virus Lineage 1 to German Poultry. 61
32899581 2020
18
West Nile Virus in Slovenia. 61
32635155 2020
19
Biocontrol of mosquito vectors through herbal-derived silver nanoparticles: prospects and challenges. 61
32385820 2020
20
Identification and characterization of long noncoding RNAs and their association with acquisition of blood meal in Culex quinquefasciatus. 61
32621332 2020
21
Synopsis of the mosquitoes (Diptera: Culicidae) of Romania. 61
33055623 2020
22
Arboviral diseases in pediatrics. 61
31605670 2020
23
The longitudinal health economic impact of viral encephalitis in the United States. 61
32040394 2020
24
Seroprevalence of Rift Valley Fever and West Nile Fever in Cattle in Gambella Region, South West Ethiopia. 61
33244452 2020
25
Chromatin Structure and Function in Mosquitoes. 61
33365050 2020
26
Viral Emerging Diseases: Challenges in Developing Vaccination Strategies. 61
33013898 2020
27
Retrospective review and current knowledge on the occurrence of West Nile virus in mosquito vectors, reservoirs and hosts in Slovakia (Central Europe). 61
32551787 2020
28
Zoonotic Diseases in Oman: Successes, Challenges, and Future Directions. 61
31486732 2020
29
Fatal case of West Nile encephalitis associated with acute anteroseptal ST elevation myocardial infarction (STEMI): a case report. 61
32334492 2020
30
A first clinical case report of west nile viral encephalitis in poltava region of Ukraine. 61
32731727 2020
31
Development of an Internally Controlled Reverse Transcription Recombinase-aided Amplification Assay for the Rapid and Visual Detection of West Nile Virus. 61
31918798 2019
32
Baseline Susceptibility of Culiseta longiareolata (Diptera: Culicidae) to Different Imagicides, in Eastern Azerbaijan, Iran. 61
32368558 2019
33
Emerging viruses in older population Chikungunya, West Nile fever and Dengue. 61
31741192 2019
34
Ecological Niche Modeling of West Nile Virus Vector in Northwest of Iran. 61
31745415 2019
35
Economic Burden of West Nile Virus Disease, Quebec, Canada, 2012-2013. 61
31538563 2019
36
West Nile fever in Europe in 2018: an emerging problem or just an anomaly? 61
31562277 2019
37
Evidence of West Nile Virus (WNV) Circulation in Wild Birds and WNV RNA Negativity in Mosquitoes of the Danube Delta Biosphere Reserve, Romania, 2016. 61
31438608 2019
38
Spectrum of Movement Disorders in Patients With Neuroinvasive West Nile Virus Infection. 61
31392241 2019
39
West Nile encephalitis mimicking neuropsychiatric lupus in a patient with systemic lupus erythematosus. 61
31345830 2019
40
Cognitive behavioural impairment with irreversible sensorineural deafness as a complication of West Nile encephalitis. 61
30903400 2019
41
Flaviviruses and Kidney Diseases. 61
31202392 2019
42
Emergent Arboviruses and Renal Transplantation: A Global Challenge. 61
31080919 2019
43
Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions. 61
30967466 2019
44
Short Communication: West Nile fever imported from Austria to Germany. 61
30462884 2019
45
The Potential of West Nile Virus Transmission Regarding the Environmental Factors Using Geographic Information System (GIS), West Azerbaijan Province, Iran. 61
31346533 2019
46
West Nile virus infections are here! Are we prepared to face another flavivirus epidemic? 61
30942263 2019
47
West Nile Virus Infection in Travelers Returning to United Kingdom from South Africa. 61
30666938 2019
48
Effect of Serratia AS1 (Enterobacteriaceae: Enterobacteriales) on the Fitness of Culex pipiens (Diptera: Culicidae) for Paratransgenic and RNAi Approaches. 61
30388221 2019
49
Quantitative Inventory of Mosquito Larvae (Diptera: Culicidae) and Physicochemical Analysis of Aquatic Habitats in the Region of Fez, Morocco. 61
31478623 2019
50
West Nile virus (lineage 2) detected for the first time in mosquitoes in Southern Bohemia: new WNV endemic area? 61
31914781 2019

Variations for West Nile Encephalitis

Expression for West Nile Encephalitis

Search GEO for disease gene expression data for West Nile Encephalitis.

Pathways for West Nile Encephalitis

Pathways related to West Nile Encephalitis according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 TLR9 TLR7 RNASEL OASL OAS3 OAS1
2
Show member pathways
13.02 RNASEL OASL OAS3 OAS1 CD4 CCR5
3
Show member pathways
12.8 TLR9 TLR7 RNASEL OAS3 OAS1
4 12.52 TLR9 RNASEL OAS3 OAS1
5
Show member pathways
12.32 TLR9 CD8A CD4 CCR5
6
Show member pathways
12.16 RNASEL OASL OAS3 OAS1
7
Show member pathways
12.14 TLR9 TLR7 RNASEL OAS3 OAS1 CLEC4M
8 12.07 TLR9 TLR7 RNASEL OAS1 CD8A
9 11.97 RNASEL OAS3 OAS1
10
Show member pathways
11.97 RNASEL OASL OAS3 OAS1
11
Show member pathways
11.72 CD8A CD4 CCR5
12
Show member pathways
11.46 TLR9 TLR7 CD4
13
Show member pathways
11.31 TLR9 TLR7 CD4
14 10.79 TLR9 TLR7 CD8A CD4

GO Terms for West Nile Encephalitis

Cellular components related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endolysosome membrane GO:0036020 8.96 TLR9 TLR7
2 early phagosome GO:0032009 8.62 TLR9 TLR7

Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.85 TLR9 TLR7 OASL OAS3 OAS1 CLEC4M
2 immune response GO:0006955 9.8 TLR9 TLR7 CD8A CD4 CCR5
3 response to virus GO:0009615 9.67 OASL OAS3 OAS1
4 type I interferon signaling pathway GO:0060337 9.62 RNASEL OASL OAS3 OAS1
5 interferon-gamma-mediated signaling pathway GO:0060333 9.61 OASL OAS3 OAS1
6 negative regulation of viral genome replication GO:0045071 9.56 RNASEL OASL OAS3 OAS1
7 immune system process GO:0002376 9.56 TLR9 TLR7 OASL OAS3 OAS1 CLEC4M
8 positive regulation of interferon-alpha production GO:0032727 9.52 TLR9 TLR7
9 toll-like receptor 9 signaling pathway GO:0034162 9.51 TLR9 TLR7
10 I-kappaB phosphorylation GO:0007252 9.48 TLR9 TLR7
11 fusion of virus membrane with host plasma membrane GO:0019064 9.46 CD4 CCR5
12 regulation of ribonuclease activity GO:0060700 9.33 OASL OAS3 OAS1
13 defense response to virus GO:0051607 9.1 TLR9 TLR7 RNASEL OASL OAS3 OAS1

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotidyltransferase activity GO:0016779 9.5 OASL OAS3 OAS1
2 drug binding GO:0008144 9.43 TLR7 CHKA
3 virus receptor activity GO:0001618 9.43 CLEC4M CD4 CCR5
4 pattern recognition receptor activity GO:0038187 9.4 TLR9 TLR7
5 siRNA binding GO:0035197 9.37 TLR9 TLR7
6 coreceptor activity GO:0015026 9.33 CD8A CD4 CCR5
7 double-stranded RNA binding GO:0003725 9.26 TLR7 OASL OAS3 OAS1
8 2'-5'-oligoadenylate synthetase activity GO:0001730 8.8 OASL OAS3 OAS1

Sources for West Nile Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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