West Nile Encephalitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for West Nile Encephalitis

MalaCards integrated aliases for West Nile Encephalitis:

Name: West Nile Encephalitis ¹¹ ¹⁴ ¹⁶

West-Nile Encephalitis ⁵⁸ ²⁸

West Nile Fever ⁴³ ⁷¹

West Nile Fever with Encephalitis ¹¹

Encephalitis, West Nile Fever ⁷¹

West Nile Fever Encephalitis ¹¹

West-Nile Fever ⁵⁸

Characteristics:

Prevelance:

West-Nile Encephalitis: 1-9/1000000 (United States, Croatia, Greece, Hungary, Romania) <1/1000000 (Europe, Austria, Italy) ⁵⁸

Age Of Onset:

West-Nile Encephalitis: All ages ⁵⁸

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Certain infectious and parasitic diseases

Arthropod-borne viral fevers and viral haemorrhagic fevers

Other mosquito-borne viral fevers

West Nile virus infection

Orphanet: ⁵⁸

Rare neurological diseases

Rare infectious diseases

External Ids:

Disease Ontology ¹¹ DOID:2365

ICD9CM ³⁴ 066.41

MeSH ⁴³ D014901

SNOMED-CT ⁶⁸ 392662004

ICD10 via Orphanet ³² A92.3

UMLS via Orphanet ⁷² C0043124 C0751583

Orphanet ⁵⁸ ORPHA83476

EFO ¹⁶ EFO_0007545

UMLS ⁷¹ C0043124 C0751583

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Summaries for West Nile Encephalitis

Disease Ontology: ¹¹ A viral infectious disease that results in inflammation located in brain, has material basis in West Nile virus, which is transmitted by Culex, Aedes, or Anopheles species of mosquitoes. The infection has symptom high fever, has symptom headache, has symptom neck stiffness, has symptom stupor, has symptom disorientation, has symptom coma, has symptom tremors, has symptom convulsions, has symptom muscle weakness, has symptom vision loss, has symptom numbness, and has symptom paralysis.

MalaCards based summary: West Nile Encephalitis, also known as west-nile encephalitis, is related to encephalitis and lymphopenia, and has symptoms including muscle weakness, headache and coma. An important gene associated with West Nile Encephalitis is MFSD6 (Major Facilitator Superfamily Domain Containing 6), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include brain, medulla oblongata and occipital lobe, and related phenotypes are immune system and cellular

Orphanet: ⁵⁸ An acute arboviral infection caused by a virus of the Flaviviridae family transmitted by an infected mosquito, that is asymptomatic in the majority of cases but that can present in rare occasions with mild flulike symptoms such as low-grade fever, arthralgia, myalgia, and/or rash, or with neurologic manifestations including meningitis, encephalitis with mental confusion or disorientation, tremors and acute flaccid paralysis/poliomyelitis.

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Related Diseases for West Nile Encephalitis

Diseases in the West Nile Encephalitis family:

West Nile Virus Encephalitis

Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 998)

#	Related Disease	Score	Top Affiliating Genes
1	encephalitis	31.6	TNF TLR3 RIGI MOG IL6 IL10
2	lymphopenia	31.0	IL6 IL2 IL10 CCR6
3	west nile fever	30.9	TLR3 RIGI IFNAR1 IFNA1 CD8A CD4
4	japanese encephalitis	30.8	TLR3 RIGI IFNAR1 IFNA1 CD8A CD4
5	chikungunya	30.7	TNF TLR3 RIGI IL6 CRP
6	optic papillitis	30.7	TNF MOG CRP CD4
7	yellow fever	30.7	RIGI IL6 IFNAR1 CRP
8	myelitis	30.7	TNF MOG IL6 IL10 CCR6 ACE2
9	crimean-congo hemorrhagic fever	30.7	IL6 IL10 IFNAR1 IFNA1
10	arachnoiditis	30.7	TNF CRP CD4
11	otitis media	30.7	TNF IL6 IL2 IL10 CRP ALB
12	vasculitis	30.6	TNF IL6 IL10 CRP
13	meningitis	30.6	TNF IL6 IL2 IL10 CRP ALB
14	q fever	30.5	TNF IL6 IL10
15	aseptic meningitis	30.5	TNF MOG IL6 IL10 IFNA1 CRP
16	viral meningitis	30.5	TNF IL6 CRP CD8A CD4 CCR6
17	acute pancreatitis	30.5	TNF IL6 IL10 CRP
18	meningoencephalitis	30.5	TNF MOG IL6 IL10 CRP CD8A
19	newcastle disease	30.5	TNF TLR3 RIGI IFNA1
20	pancreatitis	30.4	TNF IL6 IL10 CRP ALB
21	babesiosis	30.4	TNF IL10 CRP CD4 ALB
22	tick-borne encephalitis	30.4	TLR3 IFNAR1 IFNA1 CD8A CD4
23	central nervous system disease	30.3	MOG ICOSLG H2AC18 CRYAA CCR6
24	agnosia	30.3	TNF IL6 IL10 H2AC18 CRP ALB
25	myocarditis	30.3	TNF TLR3 IL6 IL2 IL10 IFNA1
26	bell's palsy	30.1	TNF TLR3 IL6 CRP CD8A CD4
27	pneumonia	30.1	TNF TLR3 IL6 IL10 CRP CD8A
28	viral infectious disease	30.0	TNF TLR3 RIGI IL6 IL2 IL10
29	dengue disease	29.9	TNF RIGI IL6 IL10 IFNAR1 IFNA1
30	poliomyelitis	29.9	TNF TLR3 RIGI IL6 IL2 IL10
31	viral encephalitis	29.9	TNF TLR3 RIGI MOG IL6 IL10
32	autoimmune disease	29.9	TNF MOG IL6 IL2 IL10 IFNA1
33	orchitis	29.9	TNF MFSD6 IL6 IL2 IL10 H2AC18
34	leukemia, chronic lymphocytic	29.9	TNF IL6 IL2 IL10 IFNA1 ICOSLG
35	exanthem	29.8	TNF IL6 IL2 IL10 IFNA1 ICOSLG
36	plague	29.7	TNF RIGI IL6 IL2 IL10 H2AC18
37	avian influenza	29.7	TNF TLR3 RIGI IL6 IL10 IFNA1
38	deficiency anemia	29.6	TNF IL6 IL2 IL10 IFNA1 ICOSLG
39	systemic lupus erythematosus	29.3	TNF TLR3 IL6 IL2 IL10 IFNAR1
40	peripheral nervous system disease	29.2	TNF RNU4ATAC MOG IL6 IL2 IL10
41	nervous system disease	28.7	TNF TLR3 RNU4ATAC RIGI MOG IL6
42	west nile virus encephalitis	11.6
43	kunjin encephalitis	11.3
44	west nile virus	10.9
45	hilar lung neoplasm	10.5	CD8A CD4
46	external pathological resorption	10.5	TNF IL6
47	oral tuberculosis	10.5	CD8A CD4
48	early yaws	10.5	CD8A CD4
49	adult acute lymphocytic leukemia	10.4	CD8A CD4 CCR6
50	ventilation pneumonitis	10.4	CRP CD8A CD4

Graphical network of the top 20 diseases related to West Nile Encephalitis:

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Symptoms & Phenotypes for West Nile Encephalitis

Symptoms:

¹¹ (show all 12)

• muscle weakness
• headache
• coma
• paralysis
• numbness
• tremors

• disorientation
• convulsions
• high fever
• stupor
• neck stiffness
• vision loss

MGI Mouse Phenotypes related to West Nile Encephalitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	10.06	ACE2 ALB CCR6 CD4 CD8A CRP
2	cellular	MP:0005384	10.03	ACE2 ALB CD4 CD8A CRYAA IFNAR1
3	neoplasm	MP:0002006	9.97	ALB IFNAR1 IL10 IL2 IL6 RIGI
4	digestive/alimentary	MP:0005381	9.97	ACE2 ALB CD4 IFNAR1 IL10 IL2
5	respiratory system	MP:0005388	9.56	ACE2 IFNA1 IFNAR1 IL10 IL2 IL6
6	hematopoietic system	MP:0005397	9.47	ACE2 CCR6 CD4 CD8A ICOSLG IFNA1

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Drugs & Therapeutics for West Nile Encephalitis

Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Vaccines		Phase 2
2	Pharmaceutical Solutions		Phase 2
3	Immunologic Factors		Phase 2
4	Immunoglobulins		Phase 2
5	Antibodies		Phase 2
6	Antibodies, Monoclonal		Phase 2

Interventional clinical trials:

(show all 13)

#	Name	Status	NCT ID	Phase	Drugs
1	Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults	Completed	NCT00442169	Phase 2
2	Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults.	Completed	NCT00746798	Phase 2
3	Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus	Terminated	NCT00927953	Phase 2
4	Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis	Completed	NCT00537147	Phase 1
5	Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis	Completed	NCT00094718	Phase 1
6	Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3´Δ30 Chimeric Virus Vaccine (WN/DEN4Δ30), a Live Attenuated Vaccine for West Nile Encephalitis, in Flavivirus-naïve Adults 50-65 Years of Age	Completed	NCT02186626	Phase 1
7	A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers	Completed	NCT00106769	Phase 1	VRC-WNVDNA017-00-VP
8	A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects	Completed	NCT00300417	Phase 1	VRC-WNVDNA020-00-VP
9	An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease	Terminated	NCT00091845	Phase 1	AVI-4020 Injection
10	Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease	Completed	NCT00069303
11	Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease	Completed	NCT00138463
12	Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus	No longer available	NCT01206504
13	Prospective Investigation of Oxidative Stress in West Nile Virus Infection	Withdrawn	NCT04371003

Search NIH Clinical Center for West Nile Encephalitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Ribavirin

Cochrane evidence based reviews: west nile fever

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Genetic Tests for West Nile Encephalitis

Genetic tests related to West Nile Encephalitis:

#	Genetic test	Affiliating Genes
1	West-Nile Encephalitis ²⁸

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Anatomical Context for West Nile Encephalitis

Organs/tissues related to West Nile Encephalitis:

MalaCards : Brain, Medulla Oblongata, Occipital Lobe, Lymph Node, B Cells, Kidney, Bone Marrow

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Publications for West Nile Encephalitis

Articles related to West Nile Encephalitis:

(show top 50) (show all 597)

#	Title	Authors	PMID	Year
1	Simple and field amenable loop-mediated isothermal amplification-lateral flow dipstick assay for detection of west Nile virus in human clinical samples. ⁶²	Tomar PS...Kumar JS	36007965	2022
2	Visualization of the Linear and Spatial Organization of Chromosomes in Mosquitoes. ⁶²	Liang J...Sharakhova MV	35960626	2022
3	Benefits, companion animal zoonotic disease prevalence and public perceptions of pet ownership among people experiencing homelessness in northern California. ⁶²	Conway KL...Foley JE	35603643	2022
4	Susceptibility of Culiseta longiareolata to insecticides in West Azerbaijan province, northwestern Iran. ⁶²	Soltanbeiglu S...Chavshin AR	36320294	2022
5	Monitoring human arboviral diseases through wastewater surveillance: Challenges, progress and future opportunities. ⁶²	Lee WL...Thompson J	36007397	2022
6	Multiple Sclerosis in a Patient With Prior West Nile Encephalitis. ⁶²	Bui B...Liu AK	36105902	2022
7	Modelling the temperature suitability for the risk of West Nile Virus establishment in European Culex pipiens populations. ⁶²	Di Pol G...Taylor RA	35304820	2022
8	West Nile Virus in Germany: An Emerging Infection and Its Relevance for Transfusion Safety. ⁶²	Frank C...Offergeld R	36159956	2022
9	Tick-borne encephalitis virus and West-Nile fever virus as causes of serous meningitis of unknown origin in Kazakhstan. ⁶²	Shin A...Essbauer S	35322572	2022
10	Text mining in mosquito-borne disease: A systematic review. ⁶²	Ong SQ...Gan KH	35430265	2022
11	Acute Fever of Unknown Origin: A Presentation of West Nile Encephalitis. ⁶²	Kamalia MA...Jha P	35857697	2022
12	Comorbid conditions as risk factors for West Nile neuroinvasive disease in Ontario, Canada: a population-based cohort study. ⁶²	Sutinen J...Kulkarni MA	35543409	2022
13	The Fauna, Diversity, and Bionomics of Culicinae (Diptera: Culicidae) in Hormozgan Province, Southern Iran. ⁶²	Jaberhashemi SA...Daghighi E	35134206	2022
14	Changing Spectrum of Acute Encephalitis Syndrome in India and a Syndromic Approach. ⁶²	Misra UK...Kalita J	35936627	2022
15	The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System. ⁶²	Korbecki J...Baranowska-Bosiacka I	35457023	2022
16	The Lack of the Association of the CCR5 Genotype with the Clinical Presentation and Frequency of Tick-Borne Encephalitis in the Polish Population. ⁶²	Grygorczuk S...Parczewski M	35335642	2022
17	Mosquito species associated with horses in Madagascar: a review of their vector status with regard to the epidemiology of West Nile fever. ⁶²	Tantely ML...Girod R	34427959	2022
18	[West Nile virus unexpectedly in the Netherlands]. ⁶²	Braks MAH...Stroo CAJ	35499516	2022
19	Anti-dengue Potential of Mangiferin: Intricate Network of Dengue to Human Genes. ⁶²	Kalaimathi K...Varatharaju G	35572718	2022
20	Detection and persistence of environmental DNA (eDNA) of the different developmental stages of a vector mosquito, Culex pipiens pallens. ⁶²	Sakata MK...Minamoto T	35947597	2022
21	Emergence of West Nile Virus Lineage-2 in Resident Corvids in Istanbul, Turkey. ⁶²	Erdogan Bamac O...Yilmaz H	34748405	2021
22	Spatiotemporal Analysis of West Nile Virus Epidemic in South Banat District, Serbia, 2017-2019. ⁶²	Radojicic S...Stanojevic S	34679972	2021
23	Primary, secondary or less frequent causes of immune thrombocytopenia: A case report. ⁶²	Onisai M...Alexandru A	34504550	2021
24	Climate change and infectious disease in Europe: Impact, projection and adaptation. ⁶²	Semenza JC...Paz S	34664039	2021
25	Phylogenetic analysis of West Nile virus: first report of lineage 1 in donkey in Turkey. ⁶²	Yildirim Y...Cagirgan AA	34536145	2021
26	West Nile fever upsurge in a Greek regional unit, 2020. ⁶²	Papa A...Mourelatos S	34129841	2021
27	[Confirmed case of a West Nile virus infection in a horse with minimal neurological signs and a favorable clinical outcome]. ⁶²	Trachsel DS...Gehlen H	34425618	2021
28	Identification and characterization of long noncoding RNAs and their association with acquisition of blood meal in Culex quinquefasciatus. ⁶²	Azlan A...Azzam G	32621332	2021
29	Unusual Movement Disorders and Atypical Magnetic Resonance Imaging (MRI) Findings in Patients with West Nile Encephalitis: Case Reports of 2 Patients with Evidence of Clinical and Imaging Resolution with IVIG. ⁶²	Sheikh IS...Sheikh A	34290220	2021
30	Seroprevalence and risk factors of West Nile virus infection in veterinarians and horses in Northern Palestine. ⁶²	Alzuheir I...Helal BA	34220126	2021
31	Mosquito surveillance of West Nile and Usutu viruses in four territorial units of Slovakia and description of a confirmed autochthonous human case of West Nile fever, 2018 to 2019. ⁶²	Cabanova V...Rudolf I	33988125	2021
32	Serological evidence of equine infectious anaemia, West Nile fever, surra and equine piroplasmosis in a herd of horses in northern Argentina. ⁶²	Hebert L...Becu T	34024382	2021
33	Emerging viruses in older population Chikungunya, West Nile fever and Dengue. ⁶²	Godaert L...Roubaud-Baudron C	31741192	2021
34	Arboviruses in the Astrakhan region of Russia for 2018 season: The development of multiplex PCR assays and analysis of mosquitoes, ticks, and human blood sera. ⁶²	Nikiforova MA...Gintsburg AL	33421655	2021
35	Current Status and a Perspective of Mosquito-Borne Diseases in the Republic of Korea. ⁶²	Im JH...Lee JS	33136531	2021
36	Management of West Nile Encephalitis: An Uncommon Complication of West Nile Virus. ⁶²	Alli A...Millhouse PW	33717727	2021
37	Sero-prevalence of West Nile virus and Rift Valley fever virus infections among cattle under extensive production system in South Omo area, southern Ethiopia. ⁶²	Endale A...Legesse M	33415465	2021
38	Predicting the spatio-temporal spread of West Nile virus in Europe. ⁶²	Garcia-Carrasco JM...Real R	33411739	2021
39	[Elucidation of neuropathogenesis of West Nile Encephalitis]. ⁶²	Kobayashi S	35526998	2021
40	Emerging and Re-emerging Vector-Borne Infectious Diseases and the Challenges for Control: A Review. ⁶²	Chala B...Hamde F	34676194	2021
41	Assessing the introduction risk of vector-borne animal diseases for the Netherlands using MINTRISK: A Model for INTegrated RISK assessment. ⁶²	de Vos CJ...de Koeijer AA	34727138	2021
42	West Nile Fever - Clinical and Epidemiological Characteristics. Review of the Literature and Contribution with Three Clinical Cases. ⁶²	Kotsev S...Pishmisheva-Peleva M	33415935	2020
43	Dengue Virus Strikes Back: Increased Future Risk of Severe Dengue Disease in Humans as a Result of Previous Exposure to Zika Virus. ⁶²	Martin-Acebes MA...Jimenez de Oya N	33339098	2020
44	Molecular Characterisation of Cytochrome Oxidase I and Internal Transcribed Spacer 2 Fragments of Culiseta longiareolata. ⁶²	Soltanbeiglu S...Chavshin AR	33269558	2020
45	[Emerging vectorial diseases: West Nile fever, Bluetongue and Schmallenberg]. ⁶²	Zientara S...Lecollinet S	33012789	2020
46	The Roles of Osteopontin in the Pathogenesis of West Nile Encephalitis. ⁶²	Nazneen F...Bai F	33317005	2020
47	Environmental drivers, climate change and emergent diseases transmitted by mosquitoes and their vectors in southern Europe: A systematic review. ⁶²	Brugueras S...Gomez-Barroso D	32810503	2020
48	Modeling the West Nile virus transfusion transmission risk in a nonoutbreak country associated with traveling donors. ⁶²	Kiely P...Wood EM	32869276	2020
49	Autochthonous West Nile virus infection outbreak in humans, Leipzig, Germany, August to September 2020. ⁶²	Pietsch C...Liebert UG	33213686	2020
50	New onset of Bell's palsy in a patient with West Nile Encephalitis. ⁶²	Vaysman T...Liu A	33088514	2020

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Genes for West Nile Encephalitis

Genes related to West Nile Encephalitis (0 elite genes):

(show all 35)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MFSD6	Major Facilitator Superfamily Domain Containing 6	Protein Coding	8.17	DISEASES inferred ¹⁴
2	CRYAA	Crystallin Alpha A	Protein Coding	8.01	DISEASES inferred ¹⁴ ¹⁴
3	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	7.34	DISEASES inferred ¹⁴ ¹⁴
4	RNU4ATAC	RNA, U4atac Small Nuclear	RNA Gene	7.27	DISEASES inferred ¹⁴ ¹⁴
5	CD4	CD4 Molecule	Protein Coding	7.23	DISEASES inferred ¹⁴
6	CD8A	CD8a Molecule	Protein Coding	7.06	DISEASES inferred ¹⁴
7	CRP	C-Reactive Protein	Protein Coding	6.53	DISEASES inferred ¹⁴
8	IL6	Interleukin 6	Protein Coding	6.43	DISEASES inferred ¹⁴
9	TNF	Tumor Necrosis Factor	Protein Coding	6.38	DISEASES inferred ¹⁴
10	H2AC18	H2A Clustered Histone 18	Protein Coding	6.38	DISEASES inferred ¹⁴ ¹⁴
11	ACE2	Angiotensin Converting Enzyme 2	Protein Coding	6.33	DISEASES inferred ¹⁴
12	IL2	Interleukin 2	Protein Coding	6.31	DISEASES inferred ¹⁴
13	IL10	Interleukin 10	Protein Coding	6.3	DISEASES inferred ¹⁴
14	TLR3	Toll Like Receptor 3	Protein Coding	6.28	DISEASES inferred ¹⁴
15	IFNA1	Interferon Alpha 1	Protein Coding	6.28	DISEASES inferred ¹⁴
16	RIGI	RNA Sensor RIG-I	Protein Coding	6.26	DISEASES inferred ¹⁴
17	ALB	Albumin	Protein Coding	6.22	DISEASES inferred ¹⁴
18	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	6.18	DISEASES inferred ¹⁴
19	MOG	Myelin Oligodendrocyte Glycoprotein	Protein Coding	6.16	DISEASES inferred ¹⁴
20	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	6.14	DISEASES inferred ¹⁴ ¹⁴
21	IL4	Interleukin 4	Protein Coding	6.13	DISEASES inferred ¹⁴
22	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	6.07	DISEASES inferred ¹⁴
23	TLR7	Toll Like Receptor 7	Protein Coding	6.02	DISEASES inferred ¹⁴
24	IFNG	Interferon Gamma	Protein Coding	6.02	DISEASES inferred ¹⁴
25	CD19	CD19 Molecule	Protein Coding	6.02	DISEASES inferred ¹⁴
26	IFNB1	Interferon Beta 1	Protein Coding	6.01	DISEASES inferred ¹⁴
27	HLA-DPB1	Major Histocompatibility Complex, Class II, DP Beta 1	Protein Coding	5.97	DISEASES inferred ¹⁴
28	IFNAR2	Interferon Alpha And Beta Receptor Subunit 2	Protein Coding	5.96	DISEASES inferred ¹⁴
29	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	5.94	DISEASES inferred ¹⁴
30	IL1B	Interleukin 1 Beta	Protein Coding	5.94	DISEASES inferred ¹⁴
31	MBP	Myelin Basic Protein	Protein Coding	5.86	DISEASES inferred ¹⁴
32	CD46	CD46 Molecule	Protein Coding	5.85	DISEASES inferred ¹⁴
33	IRF9	Interferon Regulatory Factor 9	Protein Coding	5.83	DISEASES inferred ¹⁴
34	TLR9	Toll Like Receptor 9	Protein Coding	5.79	DISEASES inferred ¹⁴
35	ERVW-1	Endogenous Retrovirus Group W Member 1, Envelope	Protein Coding	5.77	DISEASES inferred ¹⁴

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Variations for West Nile Encephalitis

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Expression for West Nile Encephalitis

Search GEO for disease gene expression data for West Nile Encephalitis.

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Pathways for West Nile Encephalitis

Pathways related to West Nile Encephalitis according to GeneCards Suite gene sharing:

(show all 39)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.91	TNF TLR3 RIGI IL6 IL2 IL10
2	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.37	TNF TLR3 IL6 IL2 IL10 CD4
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.27	CD4 IFNA1 IFNAR1 IL10 IL2 IL6
4	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.8	IFNA1 IFNAR1 IL2 IL6 RIGI TLR3
5	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.6	TNF IL6 IL2 IL10 IFNAR1 IFNA1
6	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ⁶¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ⁶¹ Immune response IL-10 signaling pathway ²² RAC1/PAK1/p38/MMP2 pathway ⁷⁴	12.56	CD4 IL10 IL2 IL6 TNF
7	NF-kappaB Signaling ³	12.49	CD8A IFNA1 IL10 IL2 RIGI TLR3
8	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.47	TNF TLR3 IL6 IFNA1
9	Cytosolic sensors of pathogen-associated DNA ⁶⁶ Show member pathways Cytosolic DNA-sensing pathway ⁷⁴ DEx/H-box helicases activate type I IFN and inflammatory cytokines production ⁶⁶ IkBA variant leads to EDA-ID ⁶⁶ IRF3 mediated activation of type 1 IFN ⁶⁶ IRF3-mediated induction of type I IFN ⁶⁶ LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production ⁶⁶ Regulation by TREX1 ⁶⁶ Regulation of innate immune responses to cytosolic DNA ⁶⁶ RIP-mediated NFkB activation via ZBP1 ⁶⁶ Selenium micronutrient network ⁷⁴ STAT6-mediated induction of chemokines ⁶⁶ STING mediated induction of host immune responses ⁶⁶ ZBP1(DAI) mediated induction of type I IFNs ⁶⁶	12.37	TLR3 RIGI IL6 IFNA1
10	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.06	TNF IL2 IL10 IFNAR1 CD8A CD4
11	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.91	TNF IL6 IL2 IL10 CD8A CD4
12	Host-pathogen interaction of human coronaviruses - interferon induction ⁷⁴ Show member pathways Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics ⁶⁰ SARS coronavirus and innate immunity ⁷⁴ Type I interferon induction and signaling during SARS-CoV-2 infection ⁷⁴	11.86	TLR3 RIGI IFNAR1 ACE2
13	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.8	TNF TLR3 IL6 IL2 IL10 CD4
14	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.76	IL6 CRP CD8A CD4 ACE2
15	Acute viral myocarditis ⁷⁴	11.73	TLR3 IL6 IL2 IL10 CD4
16	AP-1 transcription factor network ⁶¹	11.68	IL10 IL2 IL6
17	Th17 cell differentiation pathway ⁷⁴	11.68	CD4 IL2 IL6
18	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.64	TNF IL6 IL2 IL10
19	Innate Lymphoid Cells Differentiation ⁶⁵	11.64	CCR6 CD4 CD8A IL10 IL2 TNF
20	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.63	TNF IL6 IL2
21	miRNAs involvement in the immune response in sepsis ⁷⁴	11.62	TNF IL6 IL10
22	IL 10 signaling pathway ⁶⁷	11.62	TNF IL6 IL10
23	SARS-CoV-2 innate immunity evasion and cell-specific immune response ⁷⁴	11.54	TNF RIGI IL10 ACE2
24	THC Differentiation Pathway ⁶⁴	11.51	TNF IL2 IL10 IFNAR1 CD4
25	Interleukin-10 signaling ⁶⁶	11.49	TNF IL6 IL10
26	Th2 Differentiation ⁶⁵	11.48	IL2 IL10 CD4
27	Fibrin complement receptor 3 signaling pathway ⁷⁴	11.44	TNF TLR3 IL6
28	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵ Show member pathways IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	11.36	TNF IL2 IL10
29	IL-10 Pathway ⁶⁴	11.33	TNF IL6 IL10
30	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.3	TNF IL6 IL2 IL10 CD8A CD4
31	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.26	TNF IL6 ACE2
32	Immune infiltration in pancreatic cancer ⁷⁴	11.23	TNF IL6 IL2 IL10
33	Prostaglandin signaling ⁷⁴	11.22	TNF IL6 IFNA1
34	Overview of nanoparticle effects ⁷⁴	11.03	TNF IL6 CRP
35	Cytokines and inflammatory response ⁷⁴	11.02	TNF IL6 IL2 IL10 CD4
36	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	10.95	TNF IL6 IL2 IL10 ICOSLG CRP
37	COVID-19 adverse outcome pathway ⁷⁴	10.73	ACE2 IL2 IL6
38	mRNA vaccine activation of dendritic cell and induction of IFN-1 ⁷⁴	10.67	TLR3 RIGI
39	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.35	TNF IL6

Sources

GO Terms for West Nile Encephalitis

Cellular components related to West Nile Encephalitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.4	TNF MOG ICOSLG CD8A CD4 CCR6

Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

(show all 18)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.16	TNF RIGI IL6 IL10
2	positive regulation of interleukin-6 production	GO:0032755	10.1	TNF TLR3 RIGI IL6
3	response to virus	GO:0009615	10.09	TNF TLR3 RIGI IFNAR1
4	immune system process	GO:0002376	10.04	TLR3 RIGI IL2 ICOSLG CD8A CD4
5	cellular response to virus	GO:0098586	10.01	TLR3 IL6 IFNAR1 IFNA1
6	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10	TNF IL6 IL10
7	response to exogenous dsRNA	GO:0043330	9.99	TLR3 RIGI IFNA1
8	liver regeneration	GO:0097421	9.95	TNF IL6 IL10
9	defense response	GO:0006952	9.93	ICOSLG IFNA1 TLR3 TNF
10	positive regulation of interleukin-8 production	GO:0032757	9.92	TNF TLR3 RIGI IL6
11	positive regulation of immunoglobulin production	GO:0002639	9.91	IL6 IL2 IL10
12	negative regulation of cytokine production involved in immune response	GO:0002719	9.88	TNF IL10
13	humoral immune response	GO:0006959	9.86	CCR6 IFNA1 IL6 TNF
14	positive regulation of plasma cell differentiation	GO:1900100	9.76	IL10 IL2
15	regulation of cytokine production	GO:0001817	9.7	MOG IL10 ICOSLG ACE2
16	chronic inflammatory response to antigenic stimulus	GO:0002439	9.67	TNF IL10
17	negative regulation of lipid storage	GO:0010888	9.43	TNF IL6 CRP
18	immune response	GO:0006955	9.4	TNF TLR3 IL6 IL2 IL10 CD8A

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.32	TNF IL6 IL2 IL10 IFNA1

Sources

Sources for West Nile Encephalitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: WST004 MIFTS: 51	West Nile Encephalitis Categories: Infectious diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

West Nile Encephalitis

Aliases & Classifications for West Nile Encephalitis

MalaCards integrated aliases for West Nile Encephalitis:

Characteristics:

Prevelance:

Age Of Onset:

Classifications:

External Ids:

Summaries for West Nile Encephalitis

Related Diseases for West Nile Encephalitis

Diseases in the West Nile Encephalitis family:

Diseases related to West Nile Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to West Nile Encephalitis:

Symptoms & Phenotypes for West Nile Encephalitis

Symptoms:

MGI Mouse Phenotypes related to West Nile Encephalitis:

Drugs & Therapeutics for West Nile Encephalitis

Drugs for West Nile Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: west nile fever

Genetic Tests for West Nile Encephalitis

Genetic tests related to West Nile Encephalitis:

Anatomical Context for West Nile Encephalitis

Organs/tissues related to West Nile Encephalitis:

Publications for West Nile Encephalitis

Articles related to West Nile Encephalitis:

Genes for West Nile Encephalitis

Genes related to West Nile Encephalitis (0 elite genes):

Variations for West Nile Encephalitis

Expression for West Nile Encephalitis

Pathways for West Nile Encephalitis

Pathways related to West Nile Encephalitis according to GeneCards Suite gene sharing:

GO Terms for West Nile Encephalitis

Cellular components related to West Nile Encephalitis according to GeneCards Suite gene sharing:

Biological processes related to West Nile Encephalitis according to GeneCards Suite gene sharing:

Molecular functions related to West Nile Encephalitis according to GeneCards Suite gene sharing:

Sources for West Nile Encephalitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :