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MCID: WST003
MIFTS: 40

West Nile Fever

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for West Nile Fever

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MalaCards integrated aliases for West Nile Fever:

Name: West Nile Fever 12 15 71

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:2366
ICD9CM 34 066.4
MeSH 43 D014901
SNOMED-CT 67 417093003
ICD10 32 A92.3
UMLS 71 C0043124
Sources

Summaries for West Nile Fever

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Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in West Nile virus, which is transmitted by Culex and transmitted by Aedes mosquitoes. The infection has symptom fever, has symptom sore throat, has symptom headache, has symptom body ache, has symptom nausea, has symptom maculopapular rash and has symptom vomiting.

MalaCards based summary : West Nile Fever is related to west nile virus and west nile encephalitis, and has symptoms including vomiting, fever and headache. An important gene associated with West Nile Fever is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Vaccines and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and lung.

Wikipedia : 74 West Nile fever is an infection by the West Nile virus, which is typically spread by mosquitoes. In... more...

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Related Diseases for West Nile Fever

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Diseases related to West Nile Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
# Related Disease Score Top Affiliating Genes
1 west nile virus 33.9 CLEC4M CD209 CCR5
2 west nile encephalitis 31.4 RNASEL PRNT OASL OAS3 OAS1 CLEC4M
3 west nile virus infection 31.4 OAS1 CCR5
4 meningoencephalitis 30.9 CD8A CD40LG CD4
5 phlebotomus fever 30.8 PRNT CD40LG
6 rift valley fever 30.8 PRNT CD40LG CD209
7 encephalitis 30.7 ERVW-1 CLEC4M CD40LG CD209 CCR5
8 exanthem 30.6 CD8A CD40LG CD4
9 poliomyelitis 30.6 CD8A CD40LG CD4
10 st. louis encephalitis 30.6 PRNT ERVW-1 CD40LG
11 optic papillitis 30.4 CD40LG CD4
12 chikungunya 30.4 OAS3 OAS1 CD209
13 viral encephalitis 30.4 CD8A CD40LG CD4
14 severe acute respiratory syndrome 30.2 CLEC4M CD40LG CD209
15 plague 30.0 CD8A CD4 CCR5
16 tick-borne encephalitis 30.0 OAS3 OAS1 CD209 CCR5
17 dengue disease 29.5 RNASEL PRNT ERVW-1 CD8A CD40LG CD209
18 viral infectious disease 29.0 RNASEL OAS1 ERVW-1 CLEC4M CD40LG CD4
19 asymptomatic dengue 10.5 PRNT CD40LG
20 la crosse encephalitis 10.5 RNASEL CD40LG
21 kyasanur forest disease 10.5 ERVW-1 CD40LG
22 ocular toxoplasmosis 10.4 CD40LG CCR5
23 marburg hemorrhagic fever 10.4 CLEC4M CD40LG
24 murray valley encephalitis 10.4 PRNT ERVW-1 CD40LG
25 western equine encephalitis 10.4 PRNT ERVW-1 CD40LG
26 american histoplasmosis 10.3 CD40LG CD4
27 syphilitic meningitis 10.3 CD40LG CD4
28 asymptomatic neurosyphilis 10.3 CD40LG CD4
29 latent syphilis 10.3 CD40LG CD4
30 gastroduodenitis 10.3 CD40LG CD4
31 primary syphilis 10.3 CD40LG CD4
32 transient arthritis 10.3 CD40LG CD4
33 necrotizing ulcerative gingivitis 10.3 CD40LG CD4
34 neuroretinitis 10.3 CD40LG CD4
35 tertiary neurosyphilis 10.3 CD40LG CD4
36 bacillary angiomatosis 10.3 CD40LG CD4
37 meningovascular neurosyphilis 10.3 CD40LG CD4
38 opportunistic bacterial infectious disease 10.3 CD40LG CD4
39 cerebral lymphoma 10.3 CD40LG CD4
40 gastrointestinal tuberculosis 10.3 CD40LG CD4
41 exanthema subitum 10.3 CD40LG CD4
42 ventilation pneumonitis 10.3 CD8A CD4
43 mikulicz disease 10.3 CD40LG CD4
44 yellow fever 10.3 PRNT OAS1 CCR5
45 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
46 diabetes mellitus, insulin-dependent, 23 10.3 CD8A CD4
47 autoimmune peripheral neuropathy 10.3 CD40LG CD4
48 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
49 congenital syphilis 10.3 CD40LG CD4
50 bird fancier's lung 10.3 CD8A CD4

Graphical network of the top 20 diseases related to West Nile Fever:



Diseases related to West Nile Fever
Sources

Symptoms & Phenotypes for West Nile Fever

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Symptoms:

12
  • • vomiting
  • • fever
  • • headache
  • • nausea
  • • sore throat
  • • maculopapular rash
  • • body ache
Sources

Drugs & Therapeutics for West Nile Fever

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Drugs for West Nile Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Immunologic Factors Phase 2
3 Pharmaceutical Solutions Phase 2
4 Immunoglobulins Phase 2
5 Antibodies Phase 2
6 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults. Completed NCT00746798 Phase 2
2 Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
3 Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus Terminated NCT00927953 Phase 2
4 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00537147 Phase 1
5 Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00094718 Phase 1
6 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
7 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
8 An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
9 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
10 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00138463
11 Prospective Investigation of Oxidative Stress in West Nile Virus Infection Not yet recruiting NCT04371003
12 Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus No longer available NCT01206504

Search NIH Clinical Center for West Nile Fever

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ribavirin
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Genetic Tests for West Nile Fever

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Anatomical Context for West Nile Fever

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MalaCards organs/tissues related to West Nile Fever:

40
Kidney, Testes, Lung, Lymph Node, Brain, Pancreas, T Cells
Sources

Publications for West Nile Fever

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Articles related to West Nile Fever:

(show top 50) (show all 393)
# Title Authors PMID Year
1
Biocontrol of mosquito vectors through herbal-derived silver nanoparticles: prospects and challenges. 61
32385820 2020
2
Investigation of Vector-Borne Viruses in Ticks, Mosquitos, and Ruminants in the Thrace District of Turkey. 61
32397953 2020
3
Arboviral diseases in pediatrics. 61
31605670 2020
4
The longitudinal health economic impact of viral encephalitis in the United States. 61
32040394 2020
5
Zoonotic Diseases in Oman: Successes, Challenges, and Future Directions. 61
31486732 2020
6
Retrospective review and current knowledge on the occurrence of West Nile virus in mosquito vectors, reservoirs and hosts in Slovakia (Central Europe). 61
32551787 2020
7
Development of an Internally Controlled Reverse Transcription Recombinase-aided Amplification Assay for the Rapid and Visual Detection of West Nile Virus. 61
31918798 2019
8
Ecological Niche Modeling of West Nile Virus Vector in Northwest of Iran. 61
31745415 2019
9
Emerging viruses in older population Chikungunya, West Nile fever and Dengue. 61
31741192 2019
10
Economic Burden of West Nile Virus Disease, Quebec, Canada, 2012-2013. 61
31538563 2019
11
West Nile fever in Europe in 2018: an emerging problem or just an anomaly? 61
31562277 2019
12
Evidence of West Nile Virus (WNV) Circulation in Wild Birds and WNV RNA Negativity in Mosquitoes of the Danube Delta Biosphere Reserve, Romania, 2016. 61
31438608 2019
13
Emergent Arboviruses and Renal Transplantation: A Global Challenge. 61
31080919 2019
14
Flaviviruses and Kidney Diseases. 61
31202392 2019
15
Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions. 61
30967466 2019
16
Short Communication: West Nile fever imported from Austria to Germany. 61
30462884 2019
17
The Potential of West Nile Virus Transmission Regarding the Environmental Factors Using Geographic Information System (GIS), West Azerbaijan Province, Iran. 61
31346533 2019
18
West Nile virus infections are here! Are we prepared to face another flavivirus epidemic? 61
30942263 2019
19
West Nile Virus Infection in Travelers Returning to United Kingdom from South Africa. 61
30666938 2019
20
West Nile virus (lineage 2) detected for the first time in mosquitoes in Southern Bohemia: new WNV endemic area? 61
31914781 2019
21
Phenotypic insecticide resistance in arbovirus mosquito vectors in Catalonia and its capital Barcelona (Spain). 61
31276554 2019
22
West Nile fever - autochthonous human cases in South Moravia in 2018 from the epidemiological perspective. 61
31914772 2019
23
Quantitative Inventory of Mosquito Larvae (Diptera: Culicidae) and Physicochemical Analysis of Aquatic Habitats in the Region of Fez, Morocco. 61
31478623 2019
24
Co-circulation dynamics and persistence of newly introduced clades of 2012 outbreak associated West Nile Virus in Texas, 2012-2015. 61
30153478 2018
25
Emergence and Associated Risk Factors of Vector Borne West Nile Virus Infection in Ilorin, Nigeria. 61
30918903 2018
26
[Mosquitoes and Ticks: The Influence of Global Warming in the Transmission of Infectious Diseases in Germany]. 61
30440075 2018
27
West Nile virus lineage 2 in Romania, 2015-2016: co-circulation and strain replacement. 61
30367671 2018
28
Increase in human West Nile and Usutu virus infections, Austria, 2018. 61
30376913 2018
29
Conglomeration of novel Culex quinquefasciatus salivary proteins to contrive multi-epitope subunit vaccine against infections caused by blood imbibing transmitter. 61
29953889 2018
30
Does intra-individual neurocognitive variability relate to neuroinvasive disease and quality of life in West Nile Virus? 61
29696579 2018
31
Early start of the West Nile fever transmission season 2018 in Europe. 61
30107869 2018
32
Epidemiology and ecology of West Nile virus in sub-Saharan Africa. 61
30005653 2018
33
Establishment and optimization of a liquid bead array for the simultaneous detection of ten insect-borne pathogens. 61
30064470 2018
34
microRNA profiles and functions in mosquitoes. 61
29718912 2018
35
Morbidity, mortality and long-term sequelae of West Nile virus disease in Québec. 61
29587891 2018
36
Predictive Modeling for West Nile Virus and Mosquito Surveillance in Lubbock, Texas. 61
31442123 2018
37
Integrated analysis of human-animal-vector surveillance: West Nile virus infections in Austria, 2015-2016. 61
29535293 2018
38
[Human Genetic Predisposition to Diseases Caused by Viruses from Flaviviridae Family]. 61
29695688 2018
39
Newer Vaccines against Mosquito-borne Diseases. 61
28560654 2018
40
Are we prepared for emerging flaviviruses in Europe? Challenges for vaccination. 61
29053401 2018
41
Vector-borne diseases and climate change: a European perspective. 61
29149298 2018
42
Surveillance and Diagnosis of West Nile Virus in the Face of Flavivirus Cross-Reactivity. 61
30369916 2018
43
West Nile virus (lineage 2) in mosquitoes in southern Moravia - awaiting the first autochthonous human cases. 61
30157657 2018
44
Zoonotic Viral Diseases of Equines and Their Impact on Human and Animal Health. 61
30288197 2018
45
West Nile virus in horses during the summer and autumn seasons of 2015 and 2016, Portugal. 61
29173592 2017
46
Potential impact of climate change on emerging vector-borne and other infections in the UK. 61
29219091 2017
47
Serosurvey Reveals Exposure to West Nile Virus in Asymptomatic Horse Populations in Central Spain Prior to Recent Disease Foci. 61
27156847 2017
48
Epidemiologic and clinical parameters of West Nile virus infections in humans: a scoping review. 61
28877682 2017
49
Genetic Profiling and Comorbidities of Zika Infection. 61
28934431 2017
50
Improved reliability of serological tools for the diagnosis of West Nile fever in horses within Europe. 61
28915240 2017
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Variations for West Nile Fever

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Expression for West Nile Fever

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Search GEO for disease gene expression data for West Nile Fever.
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Pathways for West Nile Fever

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Pathways related to West Nile Fever according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 12.99 RNASEL OASL OAS3 OAS1 HLA-DPA1 DEFB105B
2
Cytokine Signaling in Immune system 65
Show member pathways
 12.67 RNASEL OASL OAS3 OAS1 HLA-DPA1 CD40LG
3
T cell receptor signaling pathway 36
Show member pathways
 12.38 CD8A CD40LG CD4 CCR5
4
Measles 36
Show member pathways
 12.34 RNASEL OAS3 OAS1 HLA-DPA1 CLEC4M CD209
5
NF-kappaB Signaling 4
12.29 RNASEL OAS1 CD8A CD40LG
6
Interferon gamma signaling 65
Show member pathways
 12.15 RNASEL OASL OAS3 OAS1 HLA-DPA1
7
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.03 RNASEL OASL OAS3 OAS1
8
Cell adhesion molecules (CAMs) 36
11.84 HLA-DPA1 CD8A CD40LG CD4
9
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.75 CD8A CD4 CD209
10
IL12-mediated signaling events 1
Show member pathways
 11.72 CD8A CD4 CCR5
11
Hematopoietic cell lineage 36
11.63 HLA-DPA1 CD8A CD4
12
Dendritic Cells Developmental Lineage Pathway 64
11.48 CD8A CD4 CD209
13
CTLA4 Signaling 63
11.43 HLA-DPA1 CD8A CD4
14
Primary immunodeficiency 36
11.08 CD8A CD40LG CD4
Sources

GO Terms for West Nile Fever

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Cellular components related to West Nile Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 PRNT OAS1 DEFB105B DEFB105A CLEC4M CD8A
2 cell surface GO:0009986 9.55 HLA-DPA1 CD40LG CD4 CD209 CCR5
3 integral component of plasma membrane GO:0005887 9.5 HLA-DPA1 CLEC4M CD8A CD40LG CD4 CCR5
4 external side of plasma membrane GO:0009897 9.02 CD8A CD40LG CD4 CD209 CCR5

Biological processes related to West Nile Fever according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 9.95 HLA-DPA1 CLEC4M CD8A CD4 CD209
2 innate immune response GO:0045087 9.91 OASL OAS3 OAS1 DEFB105B DEFB105A CLEC4M
3 defense response to virus GO:0051607 9.84 RNASEL OASL OAS3 OAS1
4 response to virus GO:0009615 9.76 OASL OAS3 OAS1
5 interferon-gamma-mediated signaling pathway GO:0060333 9.76 OASL OAS3 OAS1 HLA-DPA1
6 immune system process GO:0002376 9.76 OASL OAS3 OAS1 HLA-DPA1 CLEC4M CD8A
7 type I interferon signaling pathway GO:0060337 9.73 RNASEL OASL OAS3 OAS1
8 positive regulation of T cell proliferation GO:0042102 9.71 HLA-DPA1 CD40LG CD4 CD209
9 leukocyte cell-cell adhesion GO:0007159 9.65 CLEC4M CD40LG CD209
10 antigen processing and presentation GO:0019882 9.62 HLA-DPA1 CLEC4M CD8A CD209
11 viral genome replication GO:0019079 9.58 CLEC4M CD209
12 fusion of virus membrane with host plasma membrane GO:0019064 9.57 CD4 CCR5
13 modulation by virus of host morphology or physiology GO:0019048 9.56 CLEC4M CD209
14 negative regulation of viral genome replication GO:0045071 9.56 RNASEL OASL OAS3 OAS1
15 cell-cell recognition GO:0009988 9.52 CLEC4M CD209
16 virion attachment to host cell GO:0019062 9.51 CLEC4M CD209
17 peptide antigen transport GO:0046968 9.49 CLEC4M CD209
18 immune response GO:0006955 9.23 OASL OAS3 OAS1 HLA-DPA1 CD8A CD40LG
19 regulation of ribonuclease activity GO:0060700 9.13 OASL OAS3 OAS1

Molecular functions related to West Nile Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded RNA binding GO:0003725 9.5 OASL OAS3 OAS1
2 coreceptor activity GO:0015026 9.43 CD8A CD4 CCR5
3 virion binding GO:0046790 9.37 CLEC4M CD209
4 peptide antigen binding GO:0042605 9.33 HLA-DPA1 CLEC4M CD209
5 virus receptor activity GO:0001618 9.26 CLEC4M CD4 CD209 CCR5
6 2'-5'-oligoadenylate synthetase activity GO:0001730 8.8 OASL OAS3 OAS1
Sources

Sources for West Nile Fever

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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