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MCID: WST003
MIFTS: 40

West Nile Fever

Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for West Nile Fever

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MalaCards integrated aliases for West Nile Fever:

Name: West Nile Fever 12 29 15 71

Classifications:

MalaCards categories:
Global: Infectious diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:2366
ICD9CM 34 066.4
MeSH 44 D014901
SNOMED-CT 67 12381007
ICD10 32 A92.3
UMLS 71 C0043124
Sources

Summaries for West Nile Fever

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Disease Ontology : 12 A viral infectious disease that results in infection, has material basis in West Nile virus, which is transmitted by Culex and transmitted by Aedes mosquitoes. The infection has symptom fever, has symptom sore throat, has symptom headache, has symptom body ache, has symptom nausea, has symptom maculopapular rash and has symptom vomiting.

MalaCards based summary : West Nile Fever is related to west nile encephalitis and west nile virus, and has symptoms including vomiting, fever and headache. An important gene associated with West Nile Fever is OASL (2'-5'-Oligoadenylate Synthetase Like), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include kidney, lymph node and pancreas.

Wikipedia : 74 West Nile fever is an infection by the West Nile virus, which is typically spread by mosquitoes. In... more...

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Related Diseases for West Nile Fever

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Diseases related to West Nile Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 west nile encephalitis 31.9 RNASEL OASL OAS3 OAS1 CLEC4M CD8A
2 west nile virus 31.9 OAS1 IRF3 IFNA1 CLEC4M CD209 CCR5
3 chikungunya 30.6 OAS3 OAS1 CD209
4 west nile virus infection 30.5 RNASEL OASL OAS1 IRF3 CCR5
5 meningoencephalitis 30.5 CXCL10 CD8A CD4
6 poliomyelitis 30.3 IFNA1 CD8A CD4
7 exanthem 30.3 IFNA1 CD8A CD4
8 plague 30.2 CD8A CD4 CCR5
9 st. louis encephalitis 30.1 IFNA1 ERVW-1
10 encephalitis 29.9 IRF3 ERVW-1 CXCL10 CLEC4M CD209 CCR5
11 dengue disease 29.7 RNASEL IFNA1 ERVW-1 CD209
12 avian influenza 29.6 IFNA1 CXCL10 CCR5
13 viral encephalitis 29.5 IFNA1 CXCL10 CD8A CD4
14 herpes simplex 29.4 RNASEL OAS1 IRF3 IFNA1 CD209
15 newcastle disease 29.4 IRF3 IFNA1 CXCL10
16 japanese encephalitis 29.3 IRF3 IFNA1 CXCL10 CLEC4M CD209
17 tick-borne encephalitis 29.1 OAS3 OAS1 IFNA1 CXCL10 CD209 CCR5
18 severe acute respiratory syndrome 29.0 IRF3 IFNA1 CXCL10 CLEC4M CD209
19 viral infectious disease 28.2 RNASEL OAS1 IRF3 IFNA1 ERVW-1 CXCL10
20 rift valley fever 10.3
21 coccidioidomycosis 10.3
22 cork-handlers' disease 10.3 CD8A CD4
23 necrotic uveal melanoma 10.3 CD8A CD4
24 early yaws 10.3 CD8A CD4
25 ventilation pneumonitis 10.3 CD8A CD4
26 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
27 latent syphilis 10.3 CD8A CD4
28 type 1 diabetes mellitus 23 10.3 CD8A CD4
29 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
30 parapsoriasis 10.3 CD8A CD4
31 gastroduodenitis 10.3 CD8A CD4
32 duodenitis 10.3 CD8A CD4
33 primary syphilis 10.3 CD8A CD4
34 norwegian scabies 10.3 CD8A CD4
35 bird fancier's lung 10.3 CD8A CD4
36 metal allergy 10.3 CD8A CD4
37 variola major 10.3 CD8A CD4
38 follicular mucinosis 10.3 CD8A CD4
39 tertiary syphilis 10.3 CD8A CD4
40 abacavir allergy 10.3 CD4 CCR5
41 spongiotic dermatitis 10.3 CD8A CD4
42 acute retinal necrosis syndrome 10.3 CD8A CD4
43 cerebral lymphoma 10.3 CD8A CD4
44 oral tuberculosis 10.3 CD8A CD4
45 cerebritis 10.3 CD8A CD4
46 invasive malignant thymoma 10.3 CD8A CD4
47 granulomatous hepatitis 10.3 CD8A CD4
48 exanthema subitum 10.3 CD8A CD4
49 immunodeficiency 36 10.3 CD8A CD4
50 viral exanthem 10.3 CD8A CD4

Graphical network of the top 20 diseases related to West Nile Fever:



Diseases related to West Nile Fever
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Symptoms & Phenotypes for West Nile Fever

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Symptoms:

12
  • • vomiting
  • • fever
  • • headache
  • • nausea
  • • sore throat
  • • maculopapular rash
  • • body ache
Sources

Drugs & Therapeutics for West Nile Fever

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Drugs for West Nile Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Pharmaceutical Solutions Phase 2
3 Immunologic Factors Phase 2
4 Immunoglobulins Phase 2
5 Antibodies Phase 2
6 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
2 Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults. Completed NCT00746798 Phase 2
3 Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus Terminated NCT00927953 Phase 2
4 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
5 Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00094718 Phase 1
6 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00537147 Phase 1
7 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
8 An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
9 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
10 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00138463
11 Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus No longer available NCT01206504
12 Prospective Investigation of Oxidative Stress in West Nile Virus Infection Withdrawn NCT04371003

Search NIH Clinical Center for West Nile Fever

Inferred drug relations via UMLS 71 / NDF-RT 51 :


Ribavirin
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Genetic Tests for West Nile Fever

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Genetic tests related to West Nile Fever:

# Genetic test Affiliating Genes
1 West Nile Fever 29
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Anatomical Context for West Nile Fever

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MalaCards organs/tissues related to West Nile Fever:

40
Kidney, Lymph Node, Pancreas
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Publications for West Nile Fever

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Articles related to West Nile Fever:

(show top 50) (show all 414)
# Title Authors PMID Year
1
Arboviruses in the Astrakhan region of Russia for 2018 season: The development of multiplex PCR assays and analysis of mosquitoes, ticks, and human blood sera. 61
33421655 2021
2
Current Status and a Perspective of Mosquito-Borne Diseases in the Republic of Korea. 61
33136531 2021
3
Predicting the spatio-temporal spread of West Nile virus in Europe. 61
33411739 2021
4
Sero-prevalence of West Nile virus and Rift Valley fever virus infections among cattle under extensive production system in South Omo area, southern Ethiopia. 61
33415465 2021
5
Environmental drivers, climate change and emergent diseases transmitted by mosquitoes and their vectors in southern Europe: A systematic review. 61
32810503 2020
6
West Nile Fever - Clinical and Epidemiological Characteristics. Review of the Literature and Contribution with Three Clinical Cases. 61
33415935 2020
7
[Emerging vectorial diseases: West Nile fever, Bluetongue and Schmallenberg]. 61
33012789 2020
8
Dengue Virus Strikes Back: Increased Future Risk of Severe Dengue Disease in Humans as a Result of Previous Exposure to Zika Virus. 61
33339098 2020
9
Molecular Characterisation of Cytochrome Oxidase I and Internal Transcribed Spacer 2 Fragments of Culiseta longiareolata. 61
33269558 2020
10
Autochthonous West Nile virus infection outbreak in humans, Leipzig, Germany, August to September 2020. 61
33213686 2020
11
Modeling the West Nile virus transfusion transmission risk in a nonoutbreak country associated with traveling donors. 61
32869276 2020
12
Emerging Natural Focal Infectious Diseases in Russia: A Medical-Geographical Study. 61
33143199 2020
13
Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses. 61
32763313 2020
14
Investigation of Vector-Borne Viruses in Ticks, Mosquitos, and Ruminants in the Thrace District of Turkey. 61
32397953 2020
15
Pathogenicity of West Nile Virus Lineage 1 to German Poultry. 61
32899581 2020
16
West Nile Virus in Slovenia. 61
32635155 2020
17
Biocontrol of mosquito vectors through herbal-derived silver nanoparticles: prospects and challenges. 61
32385820 2020
18
Synopsis of the mosquitoes (Diptera: Culicidae) of Romania. 61
33055623 2020
19
Arboviral diseases in pediatrics. 61
31605670 2020
20
The longitudinal health economic impact of viral encephalitis in the United States. 61
32040394 2020
21
Seroprevalence of Rift Valley Fever and West Nile Fever in Cattle in Gambella Region, South West Ethiopia. 61
33244452 2020
22
Chromatin Structure and Function in Mosquitoes. 61
33365050 2020
23
Viral Emerging Diseases: Challenges in Developing Vaccination Strategies. 61
33013898 2020
24
A first clinical case report of west nile viral encephalitis in poltava region of Ukraine. 61
32731727 2020
25
Retrospective review and current knowledge on the occurrence of West Nile virus in mosquito vectors, reservoirs and hosts in Slovakia (Central Europe). 61
32551787 2020
26
Zoonotic Diseases in Oman: Successes, Challenges, and Future Directions. 61
31486732 2020
27
Development of an Internally Controlled Reverse Transcription Recombinase-aided Amplification Assay for the Rapid and Visual Detection of West Nile Virus. 61
31918798 2019
28
Ecological Niche Modeling of West Nile Virus Vector in Northwest of Iran. 61
31745415 2019
29
Emerging viruses in older population Chikungunya, West Nile fever and Dengue. 61
31741192 2019
30
Economic Burden of West Nile Virus Disease, Quebec, Canada, 2012-2013. 61
31538563 2019
31
West Nile fever in Europe in 2018: an emerging problem or just an anomaly? 61
31562277 2019
32
Evidence of West Nile Virus (WNV) Circulation in Wild Birds and WNV RNA Negativity in Mosquitoes of the Danube Delta Biosphere Reserve, Romania, 2016. 61
31438608 2019
33
Emergent Arboviruses and Renal Transplantation: A Global Challenge. 61
31080919 2019
34
Flaviviruses and Kidney Diseases. 61
31202392 2019
35
Dengue and Zika Virus 5' Untranslated Regions Harbor Internal Ribosomal Entry Site Functions. 61
30967466 2019
36
Short Communication: West Nile fever imported from Austria to Germany. 61
30462884 2019
37
The Potential of West Nile Virus Transmission Regarding the Environmental Factors Using Geographic Information System (GIS), West Azerbaijan Province, Iran. 61
31346533 2019
38
West Nile virus infections are here! Are we prepared to face another flavivirus epidemic? 61
30942263 2019
39
West Nile Virus Infection in Travelers Returning to United Kingdom from South Africa. 61
30666938 2019
40
West Nile virus (lineage 2) detected for the first time in mosquitoes in Southern Bohemia: new WNV endemic area? 61
31914781 2019
41
Phenotypic insecticide resistance in arbovirus mosquito vectors in Catalonia and its capital Barcelona (Spain). 61
31276554 2019
42
West Nile fever - autochthonous human cases in South Moravia in 2018 from the epidemiological perspective. 61
31914772 2019
43
Quantitative Inventory of Mosquito Larvae (Diptera: Culicidae) and Physicochemical Analysis of Aquatic Habitats in the Region of Fez, Morocco. 61
31478623 2019
44
Emergence and Associated Risk Factors of Vector Borne West Nile Virus Infection in Ilorin, Nigeria. 61
30918903 2018
45
Co-circulation dynamics and persistence of newly introduced clades of 2012 outbreak associated West Nile Virus in Texas, 2012-2015. 61
30153478 2018
46
[Mosquitoes and Ticks: The Influence of Global Warming in the Transmission of Infectious Diseases in Germany]. 61
30440075 2018
47
West Nile virus lineage 2 in Romania, 2015-2016: co-circulation and strain replacement. 61
30367671 2018
48
Increase in human West Nile and Usutu virus infections, Austria, 2018. 61
30376913 2018
49
Conglomeration of novel Culex quinquefasciatus salivary proteins to contrive multi-epitope subunit vaccine against infections caused by blood imbibing transmitter. 61
29953889 2018
50
Does intra-individual neurocognitive variability relate to neuroinvasive disease and quality of life in West Nile Virus? 61
29696579 2018
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Variations for West Nile Fever

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Expression for West Nile Fever

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Search GEO for disease gene expression data for West Nile Fever.
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Pathways for West Nile Fever

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Pathways related to West Nile Fever according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.39 RNASEL OASL OAS3 OAS1 IRF3 IFNA1
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.07 RNASEL OASL OAS3 OAS1 IRF3 IFNA1
3
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.84 RNASEL OAS3 OAS1 IRF3 IFNA1 CXCL10
4
Herpes simplex virus 1 infection 36
12.61 RNASEL OAS3 OAS1 IRF3 IFNA1 HLA-DPA1
5
NF-kappaB Signaling 4
12.31 RNASEL OAS1 IRF3 IFNA1 CXCL10 CD8A
6
Interferon gamma signaling 65
Show member pathways
 12.19 RNASEL OASL OAS3 OAS1 IRF3 IFNA1
7
NOD-like receptor signaling pathway 36
12.06 RNASEL OAS3 OAS1 IRF3 IFNA1
8
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.05 RNASEL OASL OAS3 OAS1 IRF3 IFNA1
9
Tuberculosis 36
12.01 IFNA1 HLA-DPA1 CLEC4M CD209
10
Measles 36
Show member pathways
 11.99 RNASEL OAS3 OAS1 IRF3 IFNA1 HLA-DPA1
11
Yersinia infection 36
11.87 IRF3 CD8A CD4
12
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.79 CD8A CD4 CD209
13
IL12-mediated signaling events 1
Show member pathways
 11.77 CD8A CD4 CCR5
14
Hematopoietic cell lineage 36
11.7 HLA-DPA1 CD8A CD4
15
Dendritic Cells Developmental Lineage Pathway 64
11.56 CD8A CD4 CD209
16
CTLA4 Signaling 63
11.52 HLA-DPA1 CD8A CD4
Sources

GO Terms for West Nile Fever

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Cellular components related to West Nile Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 OAS1 IFNA1 DEFB105B DEFB105A CXCL10 CLEC4M
2 external side of plasma membrane GO:0009897 9.02 CXCL10 CD8A CD4 CD209 CCR5

Biological processes related to West Nile Fever according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.98 IRF3 CLEC4M CD4 CD209 CCR5
2 immune response GO:0006955 9.96 HLA-DPA1 CXCL10 CD8A CD4 CCR5
3 adaptive immune response GO:0002250 9.93 IFNA1 HLA-DPA1 CLEC4M CD8A CD4 CD209
4 innate immune response GO:0045087 9.92 OASL OAS3 OAS1 IRF3 DEFB105B DEFB105A
5 cell surface receptor signaling pathway GO:0007166 9.91 CXCL10 CD8A CD4 CCR5
6 cytokine-mediated signaling pathway GO:0019221 9.89 IFNA1 CXCL10 CD4 CCR5
7 defense response GO:0006952 9.81 IFNA1 DEFB105B DEFB105A CXCL10
8 immune system process GO:0002376 9.81 OASL OAS3 OAS1 IRF3 HLA-DPA1 CLEC4M
9 response to virus GO:0009615 9.78 OASL OAS3 OAS1 CXCL10
10 antigen processing and presentation GO:0019882 9.73 HLA-DPA1 CLEC4M CD8A CD209
11 positive regulation of T cell proliferation GO:0042102 9.72 HLA-DPA1 CD4 CD209
12 negative regulation of viral genome replication GO:0045071 9.71 RNASEL OASL OAS3 OAS1
13 interferon-gamma-mediated signaling pathway GO:0060333 9.65 OASL OAS3 OAS1 IRF3 HLA-DPA1
14 response to vitamin D GO:0033280 9.61 CXCL10 CD4
15 viral genome replication GO:0019079 9.6 CLEC4M CD209
16 fusion of virus membrane with host plasma membrane GO:0019064 9.58 CD4 CCR5
17 modulation by virus of host morphology or physiology GO:0019048 9.57 CLEC4M CD209
18 cell-cell recognition GO:0009988 9.54 CLEC4M CD209
19 regulation of ribonuclease activity GO:0060700 9.54 OASL OAS3 OAS1
20 virion attachment to host cell GO:0019062 9.52 CLEC4M CD209
21 defense response to virus GO:0051607 9.5 RNASEL OASL OAS3 OAS1 IRF3 IFNA1
22 peptide antigen transport GO:0046968 9.49 CLEC4M CD209
23 type I interferon signaling pathway GO:0060337 9.1 RNASEL OASL OAS3 OAS1 IRF3 IFNA1

Molecular functions related to West Nile Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotidyltransferase activity GO:0016779 9.54 OASL OAS3 OAS1
2 double-stranded RNA binding GO:0003725 9.5 OASL OAS3 OAS1
3 mannose binding GO:0005537 9.43 CLEC4M CD209
4 coreceptor activity GO:0015026 9.43 CD8A CD4 CCR5
5 virion binding GO:0046790 9.4 CLEC4M CD209
6 peptide antigen binding GO:0042605 9.33 HLA-DPA1 CLEC4M CD209
7 virus receptor activity GO:0001618 9.26 CLEC4M CD4 CD209 CCR5
8 2'-5'-oligoadenylate synthetase activity GO:0001730 8.8 OASL OAS3 OAS1
Sources

Sources for West Nile Fever

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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