West Nile Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ A viral infectious disease that results in infection, has material basis in West Nile virus, which is transmitted by Culex and transmitted by Aedes mosquitoes. The infection has symptom fever, has symptom sore throat, has symptom headache, has symptom body ache, has symptom nausea, has symptom maculopapular rash and has symptom vomiting.

MalaCards based summary: West Nile Fever is related to west nile virus and west nile encephalitis, and has symptoms including vomiting, fever and headache. An important gene associated with West Nile Fever is ERVW-1 (Endogenous Retrovirus Group W Member 1, Envelope), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include lymph node, kidney and bone marrow, and related phenotypes are immune system and cellular

Wikipedia: ⁷⁵ West Nile fever is an infection by the West Nile virus, which is typically spread by mosquitoes. In... more...

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Related Diseases for West Nile Fever

Diseases related to West Nile Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 278)

#	Related Disease	Score	Top Affiliating Genes
1	west nile virus	31.3	RIGI OAS1 IRF3 IFNA1 CLEC4M CD209
2	west nile encephalitis	31.2	TLR3 RIGI IFNB1 IFNAR1 IFNA1 ERVW-1
3	meningoencephalitis	30.8	CXCL10 CD8A CD4
4	st. louis encephalitis	30.6	IFNA1 ERVW-1
5	exanthem	30.5	IFNA1 CD8A CD4
6	eastern equine encephalitis	30.4	FURIN ERVW-1
7	glanders	30.4	CD8A CD4
8	western equine encephalitis	30.4	FURIN ERVW-1
9	aseptic meningitis	30.2	IFNA1 CD8A CD4
10	crimean-congo hemorrhagic fever	30.1	IFNB1 IFNAR1 IFNA1 ERVW-1
11	phlebotomus fever	30.0	IRF3 IFNB1
12	myocarditis	30.0	TLR3 IFNA1 CD4 CCR5
13	chikungunya	29.8	TLR3 RIGI FURIN CD209
14	plague	29.7	RIGI CD8A CD4 CCR5
15	encephalitis	29.0	TLR3 RIGI IFNB1 IFNA1 ERVW-1 CXCL10
16	dengue disease	28.8	RNASEL RIGI IFNB1 IFNAR1 IFNA1 FURIN
17	poliomyelitis	28.7	TLR3 RIGI IRF3 IFNB1 IFNA1 CD8A
18	tick-borne encephalitis	28.4	TLR3 IFNAR1 IFNA1 FURIN ERVW-1 CXCL10
19	newcastle disease	28.4	TLR3 RIGI IRF3 IFNB1 IFNA1 CXCL10
20	viral encephalitis	28.3	TLR3 RIGI IRF3 IFNB1 IFNAR1 IFNA1
21	avian influenza	27.6	TLR3 RIGI IRF3 IFNB1 IFNA1 FURIN
22	viral infectious disease	27.6	TLR3 RNASEL RIGI OAS1 IRF3 IFNB1
23	japanese encephalitis	27.6	TLR3 RIGI IRF3 IFNB1 IFNAR1 IFNA1
24	rift valley fever	10.3
25	coccidioidomycosis	10.3
26	hilar lung neoplasm	10.3	CD8A CD4
27	oral tuberculosis	10.3	CD8A CD4
28	early yaws	10.3	CD8A CD4
29	alkhurma hemorrhagic fever	10.3	IFNAR1 ERVW-1
30	ventilation pneumonitis	10.3	CD8A CD4
31	diffuse infiltrative lymphocytosis syndrome	10.3	CD8A CD4
32	wissler-fanconi syndrome	10.3	CD8A CD4
33	autoimmune lymphoproliferative syndrome, type iia	10.3	CD8A CD4
34	encephalitozoonosis	10.3	CD8A CD4
35	type 1 diabetes mellitus 23	10.3	CD8A CD4
36	cork-handlers' disease	10.3	CD8A CD4
37	follicular mucinosis	10.3	CD8A CD4
38	suppurative lymphadenitis	10.3	CD8A CD4
39	bird fancier's lung	10.3	CD8A CD4
40	parapsoriasis	10.3	CD8A CD4
41	primary syphilis	10.3	CD8A CD4
42	granulomatous angiitis	10.3	CD8A CD4
43	primary cutaneous gamma-delta t-cell lymphoma	10.3	CD8A CD4
44	gastroduodenitis	10.3	CD8A CD4
45	thymic dysplasia	10.3	CD8A CD4
46	splenic abscess	10.3	CD8A CD4
47	mooren's ulcer	10.3	CD8A CD4
48	granulomatous dermatitis	10.3	CD8A CD4
49	acute retinal necrosis syndrome	10.3	CD8A CD4
50	granulomatous hepatitis	10.3	CD8A CD4

Graphical network of the top 20 diseases related to West Nile Fever:

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Symptoms & Phenotypes for West Nile Fever

Symptoms:

¹¹

• vomiting
• fever
• headache
• nausea

• sore throat
• maculopapular rash
• body ache

GenomeRNAi Phenotypes related to West Nile Fever according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.11	CCR5 CD209 CD4 CD8A CLEC4M CXCL10
2	no effect	GR00402-S-2	10.11	CCR5 CD209 CD4 CLEC4M CXCL10 DUSP23

MGI Mouse Phenotypes related to West Nile Fever:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	10.06	CCR5 CD209 CD4 CD8A CLEC4M CXCL10
2	cellular	MP:0005384	10.03	CCR5 CD209 CD4 CD8A CLEC4M CXCL10
3	digestive/alimentary	MP:0005381	9.87	CCR5 CD209 CD4 CLEC4M FURIN IFNAR1
4	hematopoietic system	MP:0005397	9.8	CCR5 CD209 CD4 CD8A CLEC4M CXCL10
5	mortality/aging	MP:0010768	9.44	CCR5 CD209 CD4 CD8A CLEC4M CXCL10

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Drugs & Therapeutics for West Nile Fever

Drugs for West Nile Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Vaccines		Phase 2
2	Pharmaceutical Solutions		Phase 2
3	Immunologic Factors		Phase 2
4	Immunoglobulins		Phase 2
5	Antibodies		Phase 2
6	Antibodies, Monoclonal		Phase 2

Interventional clinical trials:

(show all 12)

#	Name	Status	NCT ID	Phase	Drugs
1	Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults	Completed	NCT00442169	Phase 2
2	Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults.	Completed	NCT00746798	Phase 2
3	Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus	Terminated	NCT00927953	Phase 2
4	Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis	Completed	NCT00537147	Phase 1
5	A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers	Completed	NCT00106769	Phase 1	VRC-WNVDNA017-00-VP
6	Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis	Completed	NCT00094718	Phase 1
7	A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects	Completed	NCT00300417	Phase 1	VRC-WNVDNA020-00-VP
8	An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease	Terminated	NCT00091845	Phase 1	AVI-4020 Injection
9	Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease	Completed	NCT00069303
10	Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease	Completed	NCT00138463
11	Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus	No longer available	NCT01206504
12	Prospective Investigation of Oxidative Stress in West Nile Virus Infection	Withdrawn	NCT04371003

Search NIH Clinical Center for West Nile Fever

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Ribavirin

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Genetic Tests for West Nile Fever

Genetic tests related to West Nile Fever:

#	Genetic test	Affiliating Genes
1	West Nile Fever ²⁸

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Anatomical Context for West Nile Fever

Organs/tissues related to West Nile Fever:

MalaCards : Lymph Node, Kidney, Bone Marrow, Lung, Pancreas, Bone, Brain

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Publications for West Nile Fever

Articles related to West Nile Fever:

(show top 50) (show all 441)

#	Title	Authors	PMID	Year
1	Visualization of the Linear and Spatial Organization of Chromosomes in Mosquitoes. ⁶²	Liang J...Sharakhova MV	35960626	2022
2	Benefits, companion animal zoonotic disease prevalence and public perceptions of pet ownership among people experiencing homelessness in northern California. ⁶²	Conway KL...Foley JE	35603643	2022
3	Modelling the temperature suitability for the risk of West Nile Virus establishment in European Culex pipiens populations. ⁶²	Di Pol G...Taylor RA	35304820	2022
4	Monitoring human arboviral diseases through wastewater surveillance: Challenges, progress and future opportunities. ⁶²	Lee WL...Thompson J	36007397	2022
5	Susceptibility of Culiseta longiareolata to insecticides in West Azerbaijan province, northwestern Iran. ⁶²	Soltanbeiglu S...Chavshin AR	36320294	2022
6	West Nile Virus in Germany: An Emerging Infection and Its Relevance for Transfusion Safety. ⁶²	Frank C...Offergeld R	36159956	2022
7	Tick-borne encephalitis virus and West-Nile fever virus as causes of serous meningitis of unknown origin in Kazakhstan. ⁶²	Shin A...Essbauer S	35322572	2022
8	Text mining in mosquito-borne disease: A systematic review. ⁶²	Ong SQ...Gan KH	35430265	2022
9	The Fauna, Diversity, and Bionomics of Culicinae (Diptera: Culicidae) in Hormozgan Province, Southern Iran. ⁶²	Jaberhashemi SA...Daghighi E	35134206	2022
10	The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System. ⁶²	Korbecki J...Baranowska-Bosiacka I	35457023	2022
11	Mosquito species associated with horses in Madagascar: a review of their vector status with regard to the epidemiology of West Nile fever. ⁶²	Tantely ML...Girod R	34427959	2022
12	[West Nile virus unexpectedly in the Netherlands]. ⁶²	Braks MAH...Stroo CAJ	35499516	2022
13	Anti-dengue Potential of Mangiferin: Intricate Network of Dengue to Human Genes. ⁶²	Kalaimathi K...Varatharaju G	35572718	2022
14	Detection and persistence of environmental DNA (eDNA) of the different developmental stages of a vector mosquito, Culex pipiens pallens. ⁶²	Sakata MK...Minamoto T	35947597	2022
15	Emergence of West Nile Virus Lineage-2 in Resident Corvids in Istanbul, Turkey. ⁶²	Erdogan Bamac O...Yilmaz H	34748405	2021
16	Spatiotemporal Analysis of West Nile Virus Epidemic in South Banat District, Serbia, 2017-2019. ⁶²	Radojicic S...Stanojevic S	34679972	2021
17	Climate change and infectious disease in Europe: Impact, projection and adaptation. ⁶²	Semenza JC...Paz S	34664039	2021
18	West Nile fever upsurge in a Greek regional unit, 2020. ⁶²	Papa A...Mourelatos S	34129841	2021
19	Phylogenetic analysis of West Nile virus: first report of lineage 1 in donkey in Turkey. ⁶²	Yildirim Y...Cagirgan AA	34536145	2021
20	[Confirmed case of a West Nile virus infection in a horse with minimal neurological signs and a favorable clinical outcome]. ⁶²	Trachsel DS...Gehlen H	34425618	2021
21	Seroprevalence and risk factors of West Nile virus infection in veterinarians and horses in Northern Palestine. ⁶²	Alzuheir I...Helal BA	34220126	2021
22	Mosquito surveillance of West Nile and Usutu viruses in four territorial units of Slovakia and description of a confirmed autochthonous human case of West Nile fever, 2018 to 2019. ⁶²	Cabanova V...Rudolf I	33988125	2021
23	Serological evidence of equine infectious anaemia, West Nile fever, surra and equine piroplasmosis in a herd of horses in northern Argentina. ⁶²	Hebert L...Becu T	34024382	2021
24	Emerging viruses in older population Chikungunya, West Nile fever and Dengue. ⁶²	Godaert L...Roubaud-Baudron C	31741192	2021
25	Arboviruses in the Astrakhan region of Russia for 2018 season: The development of multiplex PCR assays and analysis of mosquitoes, ticks, and human blood sera. ⁶²	Nikiforova MA...Gintsburg AL	33421655	2021
26	Current Status and a Perspective of Mosquito-Borne Diseases in the Republic of Korea. ⁶²	Im JH...Lee JS	33136531	2021
27	Emerging and Re-emerging Vector-Borne Infectious Diseases and the Challenges for Control: A Review. ⁶²	Chala B...Hamde F	34676194	2021
28	Sero-prevalence of West Nile virus and Rift Valley fever virus infections among cattle under extensive production system in South Omo area, southern Ethiopia. ⁶²	Endale A...Legesse M	33415465	2021
29	Predicting the spatio-temporal spread of West Nile virus in Europe. ⁶²	Garcia-Carrasco JM...Real R	33411739	2021
30	Assessing the introduction risk of vector-borne animal diseases for the Netherlands using MINTRISK: A Model for INTegrated RISK assessment. ⁶²	de Vos CJ...de Koeijer AA	34727138	2021
31	Molecular Characterisation of Cytochrome Oxidase I and Internal Transcribed Spacer 2 Fragments of Culiseta longiareolata. ⁶²	Soltanbeiglu S...Chavshin AR	33269558	2020
32	Dengue Virus Strikes Back: Increased Future Risk of Severe Dengue Disease in Humans as a Result of Previous Exposure to Zika Virus. ⁶²	Martin-Acebes MA...Jimenez de Oya N	33339098	2020
33	[Emerging vectorial diseases: West Nile fever, Bluetongue and Schmallenberg]. ⁶²	Zientara S...Lecollinet S	33012789	2020
34	West Nile Fever - Clinical and Epidemiological Characteristics. Review of the Literature and Contribution with Three Clinical Cases. ⁶²	Kotsev S...Pishmisheva-Peleva M	33415935	2020
35	Environmental drivers, climate change and emergent diseases transmitted by mosquitoes and their vectors in southern Europe: A systematic review. ⁶²	Brugueras S...Gomez-Barroso D	32810503	2020
36	Autochthonous West Nile virus infection outbreak in humans, Leipzig, Germany, August to September 2020. ⁶²	Pietsch C...Liebert UG	33213686	2020
37	Modeling the West Nile virus transfusion transmission risk in a nonoutbreak country associated with traveling donors. ⁶²	Kiely P...Wood EM	32869276	2020
38	Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses. ⁶²	Konkolova E...Boura E	32763313	2020
39	Emerging Natural Focal Infectious Diseases in Russia: A Medical-Geographical Study. ⁶²	Malkhazova S...Orlov D	33143199	2020
40	Investigation of Vector-Borne Viruses in Ticks, Mosquitos, and Ruminants in the Thrace District of Turkey. ⁶²	Bilgin Z...Yilmaz H	32397953	2020
41	Pathogenicity of West Nile Virus Lineage 1 to German Poultry. ⁶²	Holicki CM...Ziegler U	32899581	2020
42	West Nile Virus in Slovenia. ⁶²	Knap N...Avsic-Zupanc T	32635155	2020
43	Biocontrol of mosquito vectors through herbal-derived silver nanoparticles: prospects and challenges. ⁶²	Kumar D...Agrawal V	32385820	2020
44	Synopsis of the mosquitoes (Diptera: Culicidae) of Romania. ⁶²	PAstrav IR...Mihalca AD	33055623	2020
45	Arboviral diseases in pediatrics. ⁶²	Martins MM...Cunha AJLAD	31605670	2020
46	The longitudinal health economic impact of viral encephalitis in the United States. ⁶²	Kiyani M...Lad SP	32040394	2020
47	Retrospective review and current knowledge on the occurrence of West Nile virus in mosquito vectors, reservoirs and hosts in Slovakia (Central Europe). ⁶²	Korytar L...Csank T	32551787	2020
48	Development and Evaluation of Real-Time Reverse Transcription Recombinase Polymerase Amplification Assay for Rapid and Sensitive Detection of West Nile Virus in Human Clinical Samples. ⁶²	Tomar PS...Kumar JS	33708642	2020
49	Viral Emerging Diseases: Challenges in Developing Vaccination Strategies. ⁶²	Trovato M...De Berardinis P	33013898	2020
50	Zoonotic Diseases in Oman: Successes, Challenges, and Future Directions. ⁶²	Awaidy SA...Al Hashami H	31486732	2020

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Genes for West Nile Fever

Genes related to West Nile Fever (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ERVW-1	Endogenous Retrovirus Group W Member 1, Envelope	Protein Coding	5.26	DISEASES inferred ¹⁴
2	OAS1	2'-5'-Oligoadenylate Synthetase 1	Protein Coding	5.24	DISEASES inferred ¹⁴
3	RNASEL	Ribonuclease L	Protein Coding	5.19	DISEASES inferred ¹⁴
4	CD8A	CD8a Molecule	Protein Coding	5.1	DISEASES inferred ¹⁴
5	OASL	2'-5'-Oligoadenylate Synthetase Like	Protein Coding	5.09	DISEASES inferred ¹⁴
6	DUSP23	Dual Specificity Phosphatase 23	Protein Coding	5.01	DISEASES inferred ¹⁴
7	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	4.9	DISEASES inferred ¹⁴
8	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	4.88	DISEASES inferred ¹⁴
9	IFNAR1	Interferon Alpha And Beta Receptor Subunit 1	Protein Coding	4.86	DISEASES inferred ¹⁴
10	CLEC4M	C-Type Lectin Domain Family 4 Member M	Protein Coding	4.84	DISEASES inferred ¹⁴
11	CD4	CD4 Molecule	Protein Coding	4.84	DISEASES inferred ¹⁴
12	CD209	CD209 Molecule	Protein Coding	4.84	DISEASES inferred ¹⁴
13	IFNA1	Interferon Alpha 1	Protein Coding	4.82	DISEASES inferred ¹⁴
14	IFNB1	Interferon Beta 1	Protein Coding	4.77	DISEASES inferred ¹⁴
15	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	4.72	DISEASES inferred ¹⁴
16	IRF3	Interferon Regulatory Factor 3	Protein Coding	4.66	DISEASES inferred ¹⁴
17	RIGI	RNA Sensor RIG-I	Protein Coding	4.63	DISEASES inferred ¹⁴
18	TLR3	Toll Like Receptor 3	Protein Coding	4.57	DISEASES inferred ¹⁴

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Variations for West Nile Fever

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Expression for West Nile Fever

Search GEO for disease gene expression data for West Nile Fever.

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Pathways for West Nile Fever

Pathways related to West Nile Fever according to GeneCards Suite gene sharing:

(show all 27)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.8	TLR3 RNASEL RIGI OASL OAS1 IRF3
2	Disease ⁶⁶ Show member pathways Infectious disease ⁶⁶	13.67	TLR3 RIGI IRF3 IFNB1 IFNAR1 IFNA1
3	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.14	CCR5 CD4 CXCL10 IFNA1 IFNAR1 IFNB1
4	SARS-CoV-2 Infection ⁶⁶ Show member pathways SARS-CoV Infections ⁶⁶ SARS-CoV-2 activates/modulates innate and adaptive immune responses ⁶⁶ SARS-CoV-2-host interactions ⁶⁶	13.11	RIGI IRF3 IFNB1 IFNAR1 IFNA1 FURIN
5	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.54	RNASEL OASL OAS1 IRF3 IFNB1 IFNAR1
6	Toll-Like receptor Signaling Pathways ⁶⁵ Show member pathways Inflammasome Activation Pathways ⁶⁵ Nanomaterial-induced inflammasome activation ⁷⁴ NOD-like Receptor Signaling Pathways ⁶⁵ TLR4 signaling and tolerance ⁷⁴ Toll-Like Receptors Pathway ⁶⁴	12.39	TLR3 IRF3 IFNB1 IFNA1
7	DDX58/IFIH1-mediated induction of interferon-alpha/beta ⁶⁶ Show member pathways Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Negative regulators of DDX58/IFIH1 signaling ⁶⁶ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁶ Novel intracellular components of RIG-I-like receptor pathway ⁷⁴ SARS-CoV-2 B.1.1.7 variant antagonises innate immune activation ⁷⁴ TRAF3-dependent IRF activation pathway ⁶⁶ TRAF6 mediated IRF7 activation ⁶⁶	12.38	TLR3 RIGI IRF3 IFNB1 IFNA1 CXCL10
8	NF-kappaB Signaling ³	12.37	TLR3 RNASEL RIGI OAS1 IRF3 IFNA1
9	Cytosolic sensors of pathogen-associated DNA ⁶⁶ Show member pathways Cytosolic DNA-sensing pathway ⁷⁴ DEx/H-box helicases activate type I IFN and inflammatory cytokines production ⁶⁶ IkBA variant leads to EDA-ID ⁶⁶ IRF3 mediated activation of type 1 IFN ⁶⁶ IRF3-mediated induction of type I IFN ⁶⁶ LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production ⁶⁶ Regulation by TREX1 ⁶⁶ Regulation of innate immune responses to cytosolic DNA ⁶⁶ RIP-mediated NFkB activation via ZBP1 ⁶⁶ Selenium micronutrient network ⁷⁴ STAT6-mediated induction of chemokines ⁶⁶ STING mediated induction of host immune responses ⁶⁶ ZBP1(DAI) mediated induction of type I IFNs ⁶⁶	12.33	CXCL10 IFNA1 IFNB1 IRF3 RIGI TLR3
10	Interferon gamma signaling ⁶⁶ Show member pathways Interferon Signaling ⁶⁶ Regulation of IFNG signaling ⁶⁶	12.24	RNASEL RIGI OASL OAS1 IRF3 IFNB1
11	Antiviral mechanism by IFN-stimulated genes ⁶⁶ Show member pathways ISG15 antiviral mechanism ⁶⁶ OAS antiviral response ⁶⁶	12.13	RNASEL RIGI OASL OAS1 IRF3
12	T-cell activation SARS-CoV-2 ⁷⁴ Show member pathways T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection ⁷⁴	12.05	IFNB1 IFNAR1 CD8A CD4
13	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.05	TLR3 RIGI OAS1 IRF3 IFNB1 IFNAR1
14	Ebola virus infection in host ⁷⁴	11.96	RIGI IRF3 CLEC4M CD209
15	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁵	11.87	CD8A CD4 CD209
16	IL12-mediated signaling events ⁶¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.85	CD8A CD4 CCR5
17	Host-pathogen interaction of human coronaviruses - interferon induction ⁷⁴ Show member pathways Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics ⁶⁰ SARS coronavirus and innate immunity ⁷⁴ Type I interferon induction and signaling during SARS-CoV-2 infection ⁷⁴	11.82	TLR3 RIGI OAS1 IRF3 IFNB1 IFNAR1
18	Interferon Pathway ⁶⁴	11.75	IFNB1 IFNAR1 IFNA1
19	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.71	IFNB1 CD8A CD4 CD209
20	Network map of SARS-CoV-2 signaling pathway ⁷⁴ Show member pathways Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex ⁷⁴	11.67	IFNB1 CD8A CD4
21	Acute viral myocarditis ⁷⁴	11.65	TLR3 CD4 CCR5
22	SARS-CoV-2 innate immunity evasion and cell-specific immune response ⁷⁴	11.46	IFNB1 IRF3 RIGI
23	Fibrin complement receptor 3 signaling pathway ⁷⁴	11.43	TLR3 IRF3 IFNB1 CXCL10
24	Type II interferon signaling ⁷⁴	11.3	OAS1 IFNB1 CXCL10
25	Selective expression of chemokine receptors during T-cell polarization ⁷⁴	10.8	CD4 CCR5
26	mRNA vaccine activation of dendritic cell and induction of IFN-1 ⁷⁴	10.69	TLR3 RIGI IRF3
27	Pathways of nucleic acid metabolism and innate immune sensing ⁷⁴	10.56	RNASEL RIGI OAS1 IRF3 IFNB1

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GO Terms for West Nile Fever

Cellular components related to West Nile Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.4	CXCL10 CLEC4M CD8A CD4 CD209 CCR5
2	host cell	GO:0043657	9.26	CLEC4M CD209

Biological processes related to West Nile Fever according to GeneCards Suite gene sharing:

(show all 28)

#	Name	GO ID	Score	Top Affiliating Genes
1	adaptive immune response	GO:0002250	10.35	CD209 CD4 CD8A CLEC4M IFNA1 IFNB1
2	cell surface receptor signaling pathway	GO:0007166	10.32	IFNB1 CXCL10 CD8A CD4 CCR5
3	innate immune response	GO:0045087	10.3	TLR3 RIGI OASL OAS1 IRF3 CLEC4M
4	viral entry into host cell	GO:0046718	10.15	CLEC4M CD4 CD209 CCR5
5	negative regulation of viral genome replication	GO:0045071	10.08	RNASEL OASL OAS1 IFNB1
6	antigen processing and presentation	GO:0019882	10.06	CLEC4M CD8A CD209
7	type I interferon-mediated signaling pathway	GO:0060337	10.03	IRF3 IFNB1 IFNAR1 IFNA1
8	immune system process	GO:0002376	10.02	TLR3 RIGI OASL OAS1 IRF3 CLEC4M
9	cellular response to interferon-beta	GO:0035458	10.01	IFNB1 OAS1 TLR3
10	positive regulation of interferon-beta production	GO:0032728	10.01	IRF3 OAS1 RIGI TLR3
11	positive regulation of interferon-alpha production	GO:0032727	9.99	TLR3 RIGI IRF3
12	antiviral innate immune response	GO:0140374	9.97	CXCL10 OAS1 RIGI
13	cellular response to exogenous dsRNA	GO:0071360	9.97	TLR3 RIGI IRF3 IFNB1
14	toll-like receptor 3 signaling pathway	GO:0034138	9.94	TLR3 OAS1
15	response to virus	GO:0009615	9.93	TLR3 RIGI OASL OAS1 IFNB1 IFNAR1
16	interleukin-27-mediated signaling pathway	GO:0070106	9.92	OASL OAS1
17	detection of virus	GO:0009597	9.91	RIGI TLR3
18	cell-cell recognition	GO:0009988	9.91	CD209 CLEC4M
19	response to exogenous dsRNA	GO:0043330	9.91	IFNA1 IFNB1 IRF3 RIGI TLR3
20	regulation of ribonuclease activity	GO:0060700	9.9	OASL OAS1
21	virion attachment to host cell	GO:0019062	9.89	CLEC4M CD209
22	intracellular transport of virus	GO:0075733	9.87	CLEC4M CD209
23	peptide antigen transport	GO:0046968	9.86	CLEC4M CD209
24	defense response	GO:0006952	9.85	TLR3 IFNB1 IFNA1 CXCL10 CCR5
25	positive regulation of cellular respiration	GO:1901857	9.81	OAS1 IFNAR1
26	cellular response to virus	GO:0098586	9.8	CXCL10 IFNA1 IFNAR1 IFNB1 IRF3 OAS1
27	biological process involved in interspecies interaction between organisms	GO:0044419	9.63	CLEC4M CD209
28	defense response to virus	GO:0051607	9.55	TLR3 RNASEL RIGI OASL OAS1 IRF3

Molecular functions related to West Nile Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:0015026	9.73	CD8A CD4 CCR5
2	virus receptor activity	GO:0001618	9.56	CLEC4M CD4 CD209 CCR5
3	2'-5'-oligoadenylate synthetase activity	GO:0001730	9.46	OASL OAS1
4	double-stranded RNA binding	GO:0003725	9.23	TLR3 RIGI OASL OAS1

Sources

Sources for West Nile Fever

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: WST003 MIFTS: 44	West Nile Fever Categories: Infectious diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

West Nile Fever

Aliases & Classifications for West Nile Fever

MalaCards integrated aliases for West Nile Fever:

Classifications:

External Ids:

Summaries for West Nile Fever

Related Diseases for West Nile Fever

Diseases related to West Nile Fever via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to West Nile Fever:

Symptoms & Phenotypes for West Nile Fever

Symptoms:

GenomeRNAi Phenotypes related to West Nile Fever according to GeneCards Suite gene sharing:

MGI Mouse Phenotypes related to West Nile Fever:

Drugs & Therapeutics for West Nile Fever

Drugs for West Nile Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Genetic Tests for West Nile Fever

Genetic tests related to West Nile Fever:

Anatomical Context for West Nile Fever

Organs/tissues related to West Nile Fever:

Publications for West Nile Fever

Articles related to West Nile Fever:

Genes for West Nile Fever

Genes related to West Nile Fever (0 elite genes):

Variations for West Nile Fever

Expression for West Nile Fever

Pathways for West Nile Fever

Pathways related to West Nile Fever according to GeneCards Suite gene sharing:

GO Terms for West Nile Fever

Cellular components related to West Nile Fever according to GeneCards Suite gene sharing:

Biological processes related to West Nile Fever according to GeneCards Suite gene sharing:

Molecular functions related to West Nile Fever according to GeneCards Suite gene sharing:

Sources for West Nile Fever

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :