MCID: WST003
MIFTS: 44

West Nile Fever

Categories: Infectious diseases
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Aliases & Classifications for West Nile Fever

MalaCards integrated aliases for West Nile Fever:

Name: West Nile Fever 11 28 14 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:2366
ICD9CM 34 066.4
MeSH 43 D014901
SNOMED-CT 68 12381007
ICD10 31 A92.3
UMLS 71 C0043124

Summaries for West Nile Fever

Disease Ontology: 11 A viral infectious disease that results in infection, has material basis in West Nile virus, which is transmitted by Culex and transmitted by Aedes mosquitoes. The infection has symptom fever, has symptom sore throat, has symptom headache, has symptom body ache, has symptom nausea, has symptom maculopapular rash and has symptom vomiting.

MalaCards based summary: West Nile Fever is related to west nile virus and west nile encephalitis, and has symptoms including vomiting, fever and headache. An important gene associated with West Nile Fever is ERVW-1 (Endogenous Retrovirus Group W Member 1, Envelope), and among its related pathways/superpathways are Innate Immune System and Disease. The drugs Vaccines and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include lymph node, kidney and bone marrow, and related phenotypes are immune system and cellular

Wikipedia: 75 West Nile fever is an infection by the West Nile virus, which is typically spread by mosquitoes. In... more...

Related Diseases for West Nile Fever

Diseases related to West Nile Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 278)
# Related Disease Score Top Affiliating Genes
1 west nile virus 31.3 RIGI OAS1 IRF3 IFNA1 CLEC4M CD209
2 west nile encephalitis 31.2 TLR3 RIGI IFNB1 IFNAR1 IFNA1 ERVW-1
3 meningoencephalitis 30.8 CXCL10 CD8A CD4
4 st. louis encephalitis 30.6 IFNA1 ERVW-1
5 exanthem 30.5 IFNA1 CD8A CD4
6 eastern equine encephalitis 30.4 FURIN ERVW-1
7 glanders 30.4 CD8A CD4
8 western equine encephalitis 30.4 FURIN ERVW-1
9 aseptic meningitis 30.2 IFNA1 CD8A CD4
10 crimean-congo hemorrhagic fever 30.1 IFNB1 IFNAR1 IFNA1 ERVW-1
11 phlebotomus fever 30.0 IRF3 IFNB1
12 myocarditis 30.0 TLR3 IFNA1 CD4 CCR5
13 chikungunya 29.8 TLR3 RIGI FURIN CD209
14 plague 29.7 RIGI CD8A CD4 CCR5
15 encephalitis 29.0 TLR3 RIGI IFNB1 IFNA1 ERVW-1 CXCL10
16 dengue disease 28.8 RNASEL RIGI IFNB1 IFNAR1 IFNA1 FURIN
17 poliomyelitis 28.7 TLR3 RIGI IRF3 IFNB1 IFNA1 CD8A
18 tick-borne encephalitis 28.4 TLR3 IFNAR1 IFNA1 FURIN ERVW-1 CXCL10
19 newcastle disease 28.4 TLR3 RIGI IRF3 IFNB1 IFNA1 CXCL10
20 viral encephalitis 28.3 TLR3 RIGI IRF3 IFNB1 IFNAR1 IFNA1
21 avian influenza 27.6 TLR3 RIGI IRF3 IFNB1 IFNA1 FURIN
22 viral infectious disease 27.6 TLR3 RNASEL RIGI OAS1 IRF3 IFNB1
23 japanese encephalitis 27.6 TLR3 RIGI IRF3 IFNB1 IFNAR1 IFNA1
24 rift valley fever 10.3
25 coccidioidomycosis 10.3
26 hilar lung neoplasm 10.3 CD8A CD4
27 oral tuberculosis 10.3 CD8A CD4
28 early yaws 10.3 CD8A CD4
29 alkhurma hemorrhagic fever 10.3 IFNAR1 ERVW-1
30 ventilation pneumonitis 10.3 CD8A CD4
31 diffuse infiltrative lymphocytosis syndrome 10.3 CD8A CD4
32 wissler-fanconi syndrome 10.3 CD8A CD4
33 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
34 encephalitozoonosis 10.3 CD8A CD4
35 type 1 diabetes mellitus 23 10.3 CD8A CD4
36 cork-handlers' disease 10.3 CD8A CD4
37 follicular mucinosis 10.3 CD8A CD4
38 suppurative lymphadenitis 10.3 CD8A CD4
39 bird fancier's lung 10.3 CD8A CD4
40 parapsoriasis 10.3 CD8A CD4
41 primary syphilis 10.3 CD8A CD4
42 granulomatous angiitis 10.3 CD8A CD4
43 primary cutaneous gamma-delta t-cell lymphoma 10.3 CD8A CD4
44 gastroduodenitis 10.3 CD8A CD4
45 thymic dysplasia 10.3 CD8A CD4
46 splenic abscess 10.3 CD8A CD4
47 mooren's ulcer 10.3 CD8A CD4
48 granulomatous dermatitis 10.3 CD8A CD4
49 acute retinal necrosis syndrome 10.3 CD8A CD4
50 granulomatous hepatitis 10.3 CD8A CD4

Graphical network of the top 20 diseases related to West Nile Fever:



Diseases related to West Nile Fever

Symptoms & Phenotypes for West Nile Fever

Symptoms:

11
  • vomiting
  • fever
  • headache
  • nausea
  • sore throat
  • maculopapular rash
  • body ache

GenomeRNAi Phenotypes related to West Nile Fever according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.11 CCR5 CD209 CD4 CD8A CLEC4M CXCL10
2 no effect GR00402-S-2 10.11 CCR5 CD209 CD4 CLEC4M CXCL10 DUSP23

MGI Mouse Phenotypes related to West Nile Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.06 CCR5 CD209 CD4 CD8A CLEC4M CXCL10
2 cellular MP:0005384 10.03 CCR5 CD209 CD4 CD8A CLEC4M CXCL10
3 digestive/alimentary MP:0005381 9.87 CCR5 CD209 CD4 CLEC4M FURIN IFNAR1
4 hematopoietic system MP:0005397 9.8 CCR5 CD209 CD4 CD8A CLEC4M CXCL10
5 mortality/aging MP:0010768 9.44 CCR5 CD209 CD4 CD8A CLEC4M CXCL10

Drugs & Therapeutics for West Nile Fever

Drugs for West Nile Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2 Pharmaceutical Solutions Phase 2
3 Immunologic Factors Phase 2
4 Immunoglobulins Phase 2
5 Antibodies Phase 2
6 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
2 Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults. Completed NCT00746798 Phase 2
3 Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus Terminated NCT00927953 Phase 2
4 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00537147 Phase 1
5 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
6 Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00094718 Phase 1
7 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
8 An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
9 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
10 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00138463
11 Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus No longer available NCT01206504
12 Prospective Investigation of Oxidative Stress in West Nile Virus Infection Withdrawn NCT04371003

Search NIH Clinical Center for West Nile Fever

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ribavirin

Genetic Tests for West Nile Fever

Genetic tests related to West Nile Fever:

# Genetic test Affiliating Genes
1 West Nile Fever 28

Anatomical Context for West Nile Fever

Organs/tissues related to West Nile Fever:

MalaCards : Lymph Node, Kidney, Bone Marrow, Lung, Pancreas, Bone, Brain

Publications for West Nile Fever

Articles related to West Nile Fever:

(show top 50) (show all 441)
# Title Authors PMID Year
1
Visualization of the Linear and Spatial Organization of Chromosomes in Mosquitoes. 62
35960626 2022
2
Benefits, companion animal zoonotic disease prevalence and public perceptions of pet ownership among people experiencing homelessness in northern California. 62
35603643 2022
3
Modelling the temperature suitability for the risk of West Nile Virus establishment in European Culex pipiens populations. 62
35304820 2022
4
Monitoring human arboviral diseases through wastewater surveillance: Challenges, progress and future opportunities. 62
36007397 2022
5
Susceptibility of Culiseta longiareolata to insecticides in West Azerbaijan province, northwestern Iran. 62
36320294 2022
6
West Nile Virus in Germany: An Emerging Infection and Its Relevance for Transfusion Safety. 62
36159956 2022
7
Tick-borne encephalitis virus and West-Nile fever virus as causes of serous meningitis of unknown origin in Kazakhstan. 62
35322572 2022
8
Text mining in mosquito-borne disease: A systematic review. 62
35430265 2022
9
The Fauna, Diversity, and Bionomics of Culicinae (Diptera: Culicidae) in Hormozgan Province, Southern Iran. 62
35134206 2022
10
The Importance of CXCL1 in Physiology and Noncancerous Diseases of Bone, Bone Marrow, Muscle and the Nervous System. 62
35457023 2022
11
Mosquito species associated with horses in Madagascar: a review of their vector status with regard to the epidemiology of West Nile fever. 62
34427959 2022
12
[West Nile virus unexpectedly in the Netherlands]. 62
35499516 2022
13
Anti-dengue Potential of Mangiferin: Intricate Network of Dengue to Human Genes. 62
35572718 2022
14
Detection and persistence of environmental DNA (eDNA) of the different developmental stages of a vector mosquito, Culex pipiens pallens. 62
35947597 2022
15
Emergence of West Nile Virus Lineage-2 in Resident Corvids in Istanbul, Turkey. 62
34748405 2021
16
Spatiotemporal Analysis of West Nile Virus Epidemic in South Banat District, Serbia, 2017-2019. 62
34679972 2021
17
Climate change and infectious disease in Europe: Impact, projection and adaptation. 62
34664039 2021
18
West Nile fever upsurge in a Greek regional unit, 2020. 62
34129841 2021
19
Phylogenetic analysis of West Nile virus: first report of lineage 1 in donkey in Turkey. 62
34536145 2021
20
[Confirmed case of a West Nile virus infection in a horse with minimal neurological signs and a favorable clinical outcome]. 62
34425618 2021
21
Seroprevalence and risk factors of West Nile virus infection in veterinarians and horses in Northern Palestine. 62
34220126 2021
22
Mosquito surveillance of West Nile and Usutu viruses in four territorial units of Slovakia and description of a confirmed autochthonous human case of West Nile fever, 2018 to 2019. 62
33988125 2021
23
Serological evidence of equine infectious anaemia, West Nile fever, surra and equine piroplasmosis in a herd of horses in northern Argentina. 62
34024382 2021
24
Emerging viruses in older population Chikungunya, West Nile fever and Dengue. 62
31741192 2021
25
Arboviruses in the Astrakhan region of Russia for 2018 season: The development of multiplex PCR assays and analysis of mosquitoes, ticks, and human blood sera. 62
33421655 2021
26
Current Status and a Perspective of Mosquito-Borne Diseases in the Republic of Korea. 62
33136531 2021
27
Emerging and Re-emerging Vector-Borne Infectious Diseases and the Challenges for Control: A Review. 62
34676194 2021
28
Sero-prevalence of West Nile virus and Rift Valley fever virus infections among cattle under extensive production system in South Omo area, southern Ethiopia. 62
33415465 2021
29
Predicting the spatio-temporal spread of West Nile virus in Europe. 62
33411739 2021
30
Assessing the introduction risk of vector-borne animal diseases for the Netherlands using MINTRISK: A Model for INTegrated RISK assessment. 62
34727138 2021
31
Molecular Characterisation of Cytochrome Oxidase I and Internal Transcribed Spacer 2 Fragments of Culiseta longiareolata. 62
33269558 2020
32
Dengue Virus Strikes Back: Increased Future Risk of Severe Dengue Disease in Humans as a Result of Previous Exposure to Zika Virus. 62
33339098 2020
33
[Emerging vectorial diseases: West Nile fever, Bluetongue and Schmallenberg]. 62
33012789 2020
34
West Nile Fever - Clinical and Epidemiological Characteristics. Review of the Literature and Contribution with Three Clinical Cases. 62
33415935 2020
35
Environmental drivers, climate change and emergent diseases transmitted by mosquitoes and their vectors in southern Europe: A systematic review. 62
32810503 2020
36
Autochthonous West Nile virus infection outbreak in humans, Leipzig, Germany, August to September 2020. 62
33213686 2020
37
Modeling the West Nile virus transfusion transmission risk in a nonoutbreak country associated with traveling donors. 62
32869276 2020
38
Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses. 62
32763313 2020
39
Emerging Natural Focal Infectious Diseases in Russia: A Medical-Geographical Study. 62
33143199 2020
40
Investigation of Vector-Borne Viruses in Ticks, Mosquitos, and Ruminants in the Thrace District of Turkey. 62
32397953 2020
41
Pathogenicity of West Nile Virus Lineage 1 to German Poultry. 62
32899581 2020
42
West Nile Virus in Slovenia. 62
32635155 2020
43
Biocontrol of mosquito vectors through herbal-derived silver nanoparticles: prospects and challenges. 62
32385820 2020
44
Synopsis of the mosquitoes (Diptera: Culicidae) of Romania. 62
33055623 2020
45
Arboviral diseases in pediatrics. 62
31605670 2020
46
The longitudinal health economic impact of viral encephalitis in the United States. 62
32040394 2020
47
Retrospective review and current knowledge on the occurrence of West Nile virus in mosquito vectors, reservoirs and hosts in Slovakia (Central Europe). 62
32551787 2020
48
Development and Evaluation of Real-Time Reverse Transcription Recombinase Polymerase Amplification Assay for Rapid and Sensitive Detection of West Nile Virus in Human Clinical Samples. 62
33708642 2020
49
Viral Emerging Diseases: Challenges in Developing Vaccination Strategies. 62
33013898 2020
50
Zoonotic Diseases in Oman: Successes, Challenges, and Future Directions. 62
31486732 2020

Variations for West Nile Fever

Expression for West Nile Fever

Search GEO for disease gene expression data for West Nile Fever.

Pathways for West Nile Fever

Pathways related to West Nile Fever according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 TLR3 RNASEL RIGI OASL OAS1 IRF3
2
Show member pathways
13.67 TLR3 RIGI IRF3 IFNB1 IFNAR1 IFNA1
3
Show member pathways
13.14 CCR5 CD4 CXCL10 IFNA1 IFNAR1 IFNB1
4
Show member pathways
13.11 RIGI IRF3 IFNB1 IFNAR1 IFNA1 FURIN
5
Show member pathways
12.54 RNASEL OASL OAS1 IRF3 IFNB1 IFNAR1
6
Show member pathways
12.39 TLR3 IRF3 IFNB1 IFNA1
7
Show member pathways
12.38 TLR3 RIGI IRF3 IFNB1 IFNA1 CXCL10
8 12.37 TLR3 RNASEL RIGI OAS1 IRF3 IFNA1
9
Show member pathways
12.33 CXCL10 IFNA1 IFNB1 IRF3 RIGI TLR3
10
Show member pathways
12.24 RNASEL RIGI OASL OAS1 IRF3 IFNB1
11
Show member pathways
12.13 RNASEL RIGI OASL OAS1 IRF3
12
Show member pathways
12.05 IFNB1 IFNAR1 CD8A CD4
13
Show member pathways
12.05 TLR3 RIGI OAS1 IRF3 IFNB1 IFNAR1
14 11.96 RIGI IRF3 CLEC4M CD209
15 11.87 CD8A CD4 CD209
16
Show member pathways
11.85 CD8A CD4 CCR5
17
Show member pathways
11.82 TLR3 RIGI OAS1 IRF3 IFNB1 IFNAR1
18 11.75 IFNB1 IFNAR1 IFNA1
19 11.71 IFNB1 CD8A CD4 CD209
20
Show member pathways
11.67 IFNB1 CD8A CD4
21 11.65 TLR3 CD4 CCR5
22 11.46 IFNB1 IRF3 RIGI
23 11.43 TLR3 IRF3 IFNB1 CXCL10
24 11.3 OAS1 IFNB1 CXCL10
25 10.8 CD4 CCR5
26 10.69 TLR3 RIGI IRF3
27 10.56 RNASEL RIGI OAS1 IRF3 IFNB1

GO Terms for West Nile Fever

Cellular components related to West Nile Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.4 CXCL10 CLEC4M CD8A CD4 CD209 CCR5
2 host cell GO:0043657 9.26 CLEC4M CD209

Biological processes related to West Nile Fever according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 adaptive immune response GO:0002250 10.35 CD209 CD4 CD8A CLEC4M IFNA1 IFNB1
2 cell surface receptor signaling pathway GO:0007166 10.32 IFNB1 CXCL10 CD8A CD4 CCR5
3 innate immune response GO:0045087 10.3 TLR3 RIGI OASL OAS1 IRF3 CLEC4M
4 viral entry into host cell GO:0046718 10.15 CLEC4M CD4 CD209 CCR5
5 negative regulation of viral genome replication GO:0045071 10.08 RNASEL OASL OAS1 IFNB1
6 antigen processing and presentation GO:0019882 10.06 CLEC4M CD8A CD209
7 type I interferon-mediated signaling pathway GO:0060337 10.03 IRF3 IFNB1 IFNAR1 IFNA1
8 immune system process GO:0002376 10.02 TLR3 RIGI OASL OAS1 IRF3 CLEC4M
9 cellular response to interferon-beta GO:0035458 10.01 IFNB1 OAS1 TLR3
10 positive regulation of interferon-beta production GO:0032728 10.01 IRF3 OAS1 RIGI TLR3
11 positive regulation of interferon-alpha production GO:0032727 9.99 TLR3 RIGI IRF3
12 antiviral innate immune response GO:0140374 9.97 CXCL10 OAS1 RIGI
13 cellular response to exogenous dsRNA GO:0071360 9.97 TLR3 RIGI IRF3 IFNB1
14 toll-like receptor 3 signaling pathway GO:0034138 9.94 TLR3 OAS1
15 response to virus GO:0009615 9.93 TLR3 RIGI OASL OAS1 IFNB1 IFNAR1
16 interleukin-27-mediated signaling pathway GO:0070106 9.92 OASL OAS1
17 detection of virus GO:0009597 9.91 RIGI TLR3
18 cell-cell recognition GO:0009988 9.91 CD209 CLEC4M
19 response to exogenous dsRNA GO:0043330 9.91 IFNA1 IFNB1 IRF3 RIGI TLR3
20 regulation of ribonuclease activity GO:0060700 9.9 OASL OAS1
21 virion attachment to host cell GO:0019062 9.89 CLEC4M CD209
22 intracellular transport of virus GO:0075733 9.87 CLEC4M CD209
23 peptide antigen transport GO:0046968 9.86 CLEC4M CD209
24 defense response GO:0006952 9.85 TLR3 IFNB1 IFNA1 CXCL10 CCR5
25 positive regulation of cellular respiration GO:1901857 9.81 OAS1 IFNAR1
26 cellular response to virus GO:0098586 9.8 CXCL10 IFNA1 IFNAR1 IFNB1 IRF3 OAS1
27 biological process involved in interspecies interaction between organisms GO:0044419 9.63 CLEC4M CD209
28 defense response to virus GO:0051607 9.55 TLR3 RNASEL RIGI OASL OAS1 IRF3

Molecular functions related to West Nile Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 9.73 CD8A CD4 CCR5
2 virus receptor activity GO:0001618 9.56 CLEC4M CD4 CD209 CCR5
3 2'-5'-oligoadenylate synthetase activity GO:0001730 9.46 OASL OAS1
4 double-stranded RNA binding GO:0003725 9.23 TLR3 RIGI OASL OAS1

Sources for West Nile Fever

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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