WNV
MCID: WST005
MIFTS: 59

West Nile Virus (WNV)

Categories: Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for West Nile Virus

MalaCards integrated aliases for West Nile Virus:

Name: West Nile Virus 57 76 53 43
West Nile Virus, Susceptibility to 57 29 13 6 40
Encephalitis, West Nile Fever 73
West Nile Viral Infection 73
Wnv, Susceptibility to 57
West-Nile Encephalitis 59
West Nile Fever 73
West-Nile Fever 59
Wnv 57

Characteristics:

Orphanet epidemiological data:

59
west-nile encephalitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

OMIM 57 610379
Orphanet 59 ORPHA83476
UMLS via Orphanet 74 C0751583 C0043124
ICD10 via Orphanet 34 A92.3

Summaries for West Nile Virus

MedlinePlus : 43 West Nile virus (WNV) is an infectious disease that first appeared in the United States in 1999. Infected mosquitoes spread the virus that causes it. People who get WNV usually have no symptoms or mild symptoms. The symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. They can last a few days to several weeks, and usually go away on their own. If West Nile virus enters the brain, however, it can be life-threatening. It may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. A physical exam, health history and laboratory tests can diagnose it. Older people and those with weakened immune systems are most at risk. There are no specific vaccines or treatments for human WNV disease. The best way to avoid WNV is to prevent mosquito bites: Use insect repellent Get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels Stay indoors between dusk and dawn, when mosquitoes are most active Use screens on windows to keep mosquitoes out NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : West Nile Virus, also known as west nile virus, susceptibility to, is related to encephalitis and japanese encephalitis, and has symptoms including seizures, tremor and fever. An important gene associated with West Nile Virus is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Glycine and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotype is immune system.

OMIM : 57 WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle between avian hosts and mosquito vectors. The virus was first isolated from a Ugandan woman in 1937 and subsequently emerged in Europe and, in 1999, in New York, with eventual spread throughout North America. WNV causes a spectrum of disease ranging from acute fever to lethal encephalitis. Susceptibility to WNV is increased in the elderly and in immunocompromised individuals (summary by Diamond and Klein (2006) and Glass et al. (2005)). (610379)

Wikipedia : 76 West Nile virus (WNV) is a single-stranded�RNA virus�that causes�West Nile fever. It is a member of the... more...

Related Diseases for West Nile Virus

Diseases related to West Nile Virus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 encephalitis 30.8 CCR5 CD209 CLEC4M DDX58 IRF3 RSAD2
2 japanese encephalitis 30.8 CD209 CLEC4M DDX58 TLR3
3 viral infectious disease 30.7 CCR5 CD209 DDX58 IFIH1 IFNA1 IRF3
4 rift valley fever 30.5 CD209 IFITM3
5 noonan syndrome 3 30.4 DDX58 IFNA1 IRF3 RSAD2 TLR3
6 tick-borne encephalitis 30.2 CCR5 CD209 OAS1 TLR3
7 dengue virus 30.2 CD209 DDX58 EXOC1 IFIH1 IFITM1 IFITM2
8 severe acute respiratory syndrome 30.1 CD209 CLEC4M IFNA1 IRF3
9 yellow fever 30.1 CCR5 OAS1 RSAD2
10 newcastle disease 29.8 DDX58 IFNA1 IRF3
11 hepatitis c 29.8 CLEC4M DDX58 IFNA1 IRF3 TLR3
12 measles 29.6 CD209 DDX58 IFIH1 IFNA1 TLR3
13 human immunodeficiency virus type 1 29.4 CCR5 CD209 CLEC4M IRF3 LOC102724297 TLR3
14 hepatitis c virus 29.4 CCR5 CLEC4M DDX58 IFIH1 IFITM1 IRF3
15 herpes simplex 29.1 CD209 DDX58 IFIH1 IFNA1 IRF3 ITGAV
16 influenza 28.9 DDX58 IFIH1 IFITM1 IFITM2 IFITM3 IFNA1
17 west nile encephalitis 11.9
18 west nile fever 11.9
19 acute flaccid myelitis 11.6
20 kunjin encephalitis 11.4
21 meningoencephalitis 10.7
22 st. louis encephalitis 10.5
23 chorioretinitis 10.5
24 meningitis 10.5
25 noonan syndrome 5 10.4
26 poliomyelitis 10.4
27 chikungunya 10.3
28 myoclonus 10.3
29 coccidioidomycosis 10.3
30 vasculitis 10.3
31 myasthenia gravis 10.2
32 retinal vasculitis 10.2
33 myasthenia gravis congenital 10.2
34 opsoclonus-myoclonus syndrome 10.2
35 aceruloplasminemia 10.2
36 malaria 10.2
37 hepatitis 10.2
38 eastern equine encephalitis 10.2
39 murray valley encephalitis 10.2
40 pica disease 10.2
41 aseptic meningitis 10.2
42 quadriplegia 10.2
43 xanthogranulomatous cholecystitis 10.2
44 singleton-merten syndrome 10.1 DDX58 IFIH1
45 ichthyosis prematurity syndrome 10.1
46 dengue disease 10.1
47 hepatitis b 10.1
48 exanthem 10.1
49 lymphocytic leukemia 10.1
50 filariasis 10.1

Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to West Nile Virus

Symptoms & Phenotypes for West Nile Virus

Clinical features from OMIM:

610379

UMLS symptoms related to West Nile Virus:


seizures, tremor, fever, pruritus, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to West Nile Virus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 CCR5 CFH CLEC4M DDX58 IFIH1 IFITM3

Drugs & Therapeutics for West Nile Virus

Drugs for West Nile Virus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
2 Antibodies Phase 2,Phase 1
3 Immunoglobulins, Intravenous Phase 2,Phase 1
4 Immunoglobulin G Phase 2,Phase 1
5 gamma-Globulins Phase 2,Phase 1
6 Rho(D) Immune Globulin Phase 2,Phase 1
7 Immunoglobulins Phase 2,Phase 1
8 Pharmaceutical Solutions Phase 1, Phase 2,Phase 2
9 Immunologic Factors Phase 1, Phase 2,Phase 2
10 Antibodies, Monoclonal Phase 2,Phase 1
11 Vaccines Phase 2,Phase 1
12
Aluminum sulfate Approved Phase 1 10043-01-3
13
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
14 Gastrointestinal Agents Phase 1
15 Anti-Ulcer Agents Phase 1
16 Antacids Phase 1
17 Adjuvants, Immunologic Phase 1

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus Disease Completed NCT00069316 Phase 2 Omr-IgG-am
2 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
3 Treatment of West Nile Virus With MGAWN1 Terminated NCT00927953 Phase 2
4 Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults Completed NCT00746798 Phase 2
5 Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
6 Phase 1 Trial of Inactivated West Nile Virus Vaccine Completed NCT02337868 Phase 1
7 Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of Age Completed NCT02186626 Phase 1
8 Phase I Study of West Nile Virus Vaccine Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
9 A Trial to Evaluate the Safety of a Single Intravenous Infusion of MGAWN1 in Healthy Adults Completed NCT00515385 Phase 1 MGAWN1;MGAWN1
10 Vaccine to Prevent West Nile Virus Disease Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
11 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
12 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
13 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Completed NCT00537147 Phase 1
14 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults Completed NCT00094718 Phase 1
15 Safety Study of HBV-002 West Nile Vaccine in Healthy Adults Completed NCT00707642 Phase 1
16 Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal Fluid Completed NCT00381433 Phase 1 AVI-4065 Injection
17 West Nile Virus Natural History Completed NCT00138463
18 Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure No longer available NCT01206504
19 Natural History of West Nile Virus Infection Completed NCT00069303
20 Surveillance of Summer Febrile Syndromes of Viral Origin in South of France Completed NCT00842166 Not Applicable
21 VRC 300: Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases Completed NCT00068926
22 Organ Transplant Infection Prevention and Detection Project Completed NCT00177801
23 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
24 Retrovirus Epidemiology Donor Study-II (REDS-II) Completed NCT00097006

Search NIH Clinical Center for West Nile Virus

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for West Nile Virus

Genetic tests related to West Nile Virus:

# Genetic test Affiliating Genes
1 West Nile Virus, Susceptibility to 29 CCR5

Anatomical Context for West Nile Virus

MalaCards organs/tissues related to West Nile Virus:

41
Brain, Testes, Spinal Cord, T Cells, Skin, B Cells, Kidney

Publications for West Nile Virus

Articles related to West Nile Virus:

(show top 50) (show all 1528)
# Title Authors Year
1
Phosphonate inhibitors of West Nile virus NS2B/NS3 protease. ( 30362835 )
2019
2
Spatiotemporal Bayesian modeling of West Nile virus: Identifying risk of infection in mosquitoes with local-scale predictors. ( 30373059 )
2019
3
A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions. ( 30455471 )
2019
4
West Nile virus in Algeria: a comprehensive overview. ( 30519477 )
2019
5
Prevalence of Usutu and West Nile virus antibodies in human sera, Modena, Italy, 2012. ( 29797606 )
2018
6
First isolation of West Nile virus in Zambia from mosquitoes. ( 29722174 )
2018
7
Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge <i>Amphimedon chloros</i> with <i>In Vitro</i> Inhibitory Activity against the West Nile Virus NS3 Protease. ( 29912151 )
2018
8
Does intra-individual neurocognitive variability relate to neuroinvasive disease and quality of life in West Nile Virus? ( 29696579 )
2018
9
Selective constraint and adaptive potential of West Nile virus within and among naturally infected avian hosts and mosquito vectors. ( 29942654 )
2018
10
West Nile Virus and Usutu Virus Monitoring of Wild Birds in Germany. ( 29361762 )
2018
11
Ovicidal and Larvicidal Effects of Garlic and Asafoetida Essential Oils Against West Nile Virus Vectors. ( 29718505 )
2018
12
Experimental evaluation of infection, dissemination, and transmission rates for two West Nile virus strains in European Aedes japonicus under a fluctuating temperature regime. ( 29705877 )
2018
13
Evaluation of real-time reverse-transcription loop-mediated isothermal amplification assay for clinical diagnosis of West Nile virus in patients. ( 29923519 )
2018
14
Splenic macrophages are required for protective innate immunity against West Nile virus. ( 29408905 )
2018
15
West Nile Virus and Other Nationally Notifiable Arboviral Diseases - United States, 2016. ( 29324725 )
2018
16
A four-year survey (2011-2014) of West Nile virus infection in humans, mosquitoes and birds, including the 2012 meningoencephalitis outbreak in Tunisia. ( 29535295 )
2018
17
Increased Human Incidence of West Nile Virus Disease near Rice Fields in California but Not in Southern United States. ( 29714160 )
2018
18
Population genetic structure of the Culex pipiens (Diptera: Culicidae) complex, vectors of West Nile virus, in five habitats. ( 29301567 )
2018
19
Enhanced production and immunological characterization of recombinant West Nile virus envelope domain III protein. ( 29768182 )
2018
20
Absence of protection from West Nile virus disease and adverse effects in red legged partridges after non-structural NS1 protein administration. ( 29406280 )
2018
21
West Nile virus and other mosquito-borne viruses present in Eastern Europe. ( 29979950 )
2018
22
Attenuation of West Nile Virus NS2B/NS3 Protease by Amino Terminal Copper and Nickel Binding (ATCUN) Peptides. ( 29301071 )
2018
23
Serosurvey of West Nile virus in household-reared pigeons in Bauchi metropolis, Nigeria. ( 29788268 )
2018
24
Improving the prediction of arbovirus outbreaks: A comparison of climate-driven models for West Nile virus in an endemic region of the United States. ( 29727611 )
2018
25
Exposure to West Nile virus and tick-borne encephalitis virus in dogs in Spain. ( 29322674 )
2018
26
Correction: An ImmunoSignature test distinguishes Trypanosoma cruzi, hepatitis B, hepatitis C and West Nile virus seropositivity among asymptomatic blood donors. ( 29389963 )
2018
27
Antibodies to West Nile virus in Mexican pigs. ( 29916452 )
2018
28
Seroprevalence of Dengue Virus, West Nile Virus, Chikungunya Virus, and Zika Virus in International Travelers Attending a Travel and Migration Center in 2015-2017, Southern Italy. ( 29683399 )
2018
29
A monoclonal antibody to DIII E protein allowing the differentiation of West Nile virus from other flaviviruses by a Lateral Flow Assay. ( 29958922 )
2018
30
Ocular manifestations of emerging arboviruses: Dengue fever, Chikungunya, Zika virus, West Nile virus, and yellow fever. ( 29929827 )
2018
31
Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis. ( 29929468 )
2018
32
Mating behavior of the West Nile virus vector Culex pipiens - role of behavioral asymmetries. ( 29288628 )
2018
33
Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus. ( 29709018 )
2018
34
Mosquito community influences West Nile virus seroprevalence in wild birds: implications for the risk of spillover into human populations. ( 29422507 )
2018
35
Increases in the competitive fitness of West Nile virus isolates after introduction into California. ( 29195094 )
2018
36
Experimental transmission of West Nile Virus and Rift Valley Fever Virus by Culex pipiens from Lebanon. ( 29324834 )
2018
37
Surveillance for Flaviviruses Near the Mexico-U.S. Border: Co-circulation of Dengue Virus Serotypes 1, 2, and 3 and West Nile Virus in Tamaulipas, Northern Mexico, 2014-2016. ( 30226141 )
2018
38
A plant-produced vaccine protects mice against lethal West Nile virus infection without enhancing Zika or dengue virus infectivity. ( 29490880 )
2018
39
Lethal disseminated dysembryoplastic neuroepithelial tumor following West Nile virus: Report of a very unusual combination. ( 29988761 )
2018
40
West-Nile virus encephalitis in an immunocompetent pediatric patient: successful recovery. ( 30458831 )
2018
41
West Nile virus associated with equid encephalitis in Brazil, 2018. ( 30318735 )
2018
42
Correction for Kumar et al., "Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis". ( 30018145 )
2018
43
Myelopathy in West Nile virus encephalitis: Report of a case and review of literature. ( 30124385 )
2018
44
Human monoclonal antibodies against West Nile virus from Japanese encephalitis-vaccinated volunteers. ( 29665373 )
2018
45
Detection of West Nile Virus Infection in Viral Encephalitis Cases, China. ( 29985780 )
2018
46
Brought Down by a Mosquito? West Nile Virus Encephalitis. ( 29571980 )
2018
47
West Nile virus induces a post-infectious pro-inflammatory state that explains transformation of stable ocular myasthenia gravis to myasthenic crises. ( 30267806 )
2018
48
Opsoclonus-Myoclonus Syndrome Associated With West-Nile Virus Infection: Case Report and Review of the Literature. ( 30386288 )
2018
49
The First Case Report of West Nile Virus-Induced Acute Flaccid Quadriplegia in Canada. ( 30123588 )
2018
50
Breathing new life into West Nile virus therapeutics; discovery and study of zafirlukast as an NS2B-NS3 protease inhibitor. ( 30193218 )
2018

Variations for West Nile Virus

ClinVar genetic disease variations for West Nile Virus:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CCR5 NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs) deletion protective,risk factor rs333 GRCh37 Chromosome 3, 46414947: 46414978
2 CCR5 NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs) deletion protective,risk factor rs333 GRCh38 Chromosome 3, 46373456: 46373487

Expression for West Nile Virus

Search GEO for disease gene expression data for West Nile Virus.

Pathways for West Nile Virus

Pathways related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 CCR5 CD209 CFH DDX58 IFIH1 IFITM1
2
Show member pathways
13.18 CCR5 DDX58 IFITM1 IFITM2 IFITM3 IFNA1
3
Show member pathways
12.92 CCR5 DDX58 IFIH1 IFNA1 IRF3 ITGAV
4
Show member pathways
12.57 DDX58 IFIH1 IFNA1 IRF3 TLR3
5 12.32 DDX58 IFIH1 IFNA1 IRF3 OAS1 RSAD2
6
Show member pathways
12.26 DDX58 IFIH1 IRF3 TLR3
7
Show member pathways
12.24 IRF3 ITGAV ITGB3 TLR3
8 12.1 DDX58 IFNA1 IRF3 OAS1
9
Show member pathways
12.08 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 OAS1
10
Show member pathways
12.05 DDX58 IFITM1 IFITM2 IFITM3 IFNA1 IRF3
11 11.96 CD209 CLEC4M ITGAV ITGB3
12
Show member pathways
11.96 CD209 CLEC4M DDX58 IFIH1 IFNA1 IRF3
13 11.92 DDX58 IFNA1 IRF3 OAS1 TLR3
14 11.82 CD209 ITGAV ITGB3
15 11.63 ITGAV ITGB3 TLR3
16
Show member pathways
10.99 DDX58 IRF3 OAS1
17 10.91 ITGAV ITGB3
18 10.7 ITGAV ITGB3
19 10.62 ITGAV ITGB3

GO Terms for West Nile Virus

Cellular components related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.83 CCR5 CD209 ITGAV ITGB3 TLR3
2 ruffle membrane GO:0032587 9.5 DDX58 ITGAV ITGB3
3 lamellipodium membrane GO:0031258 9.46 ITGAV ITGB3
4 filopodium membrane GO:0031527 9.4 ITGAV ITGB3
5 host cell GO:0043657 9.37 CD209 CLEC4M
6 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 9.26 ITGAV ITGB3
7 alphav-beta3 integrin-HMGB1 complex GO:0035868 9.16 ITGAV ITGB3
8 alphav-beta3 integrin-PKCalpha complex GO:0035866 8.96 ITGAV ITGB3
9 integrin alphav-beta3 complex GO:0034683 8.62 ITGAV ITGB3

Biological processes related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.93 CD209 CFH CLEC4M DDX58 IFIH1 IFITM1
2 type I interferon signaling pathway GO:0060337 9.87 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 OAS1
3 viral entry into host cell GO:0046718 9.86 CD209 CLEC4M ITGAV ITGB3
4 response to virus GO:0009615 9.86 DDX58 IFIH1 IFITM1 IFITM2 IFITM3 OAS1
5 response to exogenous dsRNA GO:0043330 9.78 DDX58 IFNA1 IRF3 TLR3
6 negative regulation of type I interferon production GO:0032480 9.77 DDX58 IFIH1 IRF3
7 negative regulation of viral genome replication GO:0045071 9.77 IFITM1 IFITM2 IFITM3 OAS1 RSAD2
8 response to interferon-gamma GO:0034341 9.74 IFITM1 IFITM2 IFITM3
9 positive regulation of interferon-beta production GO:0032728 9.73 DDX58 IFIH1 IRF3 TLR3
10 viral process GO:0016032 9.73 CCR5 CD209 CFH CLEC4M DDX58 EXOC1
11 negative regulation of viral entry into host cell GO:0046597 9.72 IFITM1 IFITM2 IFITM3
12 cellular response to exogenous dsRNA GO:0071360 9.71 DDX58 IFIH1 TLR3
13 positive regulation of interferon-alpha production GO:0032727 9.7 DDX58 IFIH1 IRF3
14 response to interferon-alpha GO:0035455 9.69 IFITM1 IFITM2 IFITM3
15 cell adhesion mediated by integrin GO:0033627 9.68 ITGAV ITGB3
16 apoptotic cell clearance GO:0043277 9.68 ITGAV ITGB3
17 cell-substrate adhesion GO:0031589 9.68 ITGAV ITGB3
18 positive regulation of tumor necrosis factor secretion GO:1904469 9.68 DDX58 IFIH1
19 viral genome replication GO:0019079 9.67 CD209 CLEC4M
20 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.67 ITGAV ITGB3
21 intracellular transport of virus GO:0075733 9.67 CD209 CLEC4M
22 response to interferon-beta GO:0035456 9.67 IFITM1 IFITM2 IFITM3
23 positive regulation of interferon-alpha secretion GO:1902741 9.66 DDX58 IFIH1
24 negative regulation of lipid storage GO:0010888 9.66 ITGAV ITGB3
25 modulation by virus of host morphology or physiology GO:0019048 9.65 CD209 CLEC4M
26 apolipoprotein A-I-mediated signaling pathway GO:0038027 9.65 ITGAV ITGB3
27 cell-cell recognition GO:0009988 9.65 CD209 CLEC4M
28 cellular response to dsRNA GO:0071359 9.64 IRF3 TLR3
29 positive regulation of response to cytokine stimulus GO:0060760 9.64 DDX58 IFIH1
30 positive regulation of interferon-beta secretion GO:0035549 9.63 DDX58 IFIH1
31 virion attachment to host cell GO:0019062 9.63 CD209 CLEC4M
32 detection of virus GO:0009597 9.63 DDX58 IFIH1 TLR3
33 negative regulation of lipid transport GO:0032369 9.62 ITGAV ITGB3
34 MDA-5 signaling pathway GO:0039530 9.62 IFIH1 IRF3
35 negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715 9.61 ITGAV ITGB3
36 peptide antigen transport GO:0046968 9.61 CD209 CLEC4M
37 cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 9.59 DDX58 IFIH1
38 negative regulation of lipoprotein metabolic process GO:0050748 9.58 ITGAV ITGB3
39 regulation of type III interferon production GO:0034344 9.58 DDX58 IFIH1
40 defense response to virus GO:0051607 9.36 DDX58 EXOC1 IFIH1 IFITM1 IFITM2 IFITM3
41 immune system process GO:0002376 10.06 CD209 CLEC4M DDX58 IFIH1 IFITM1 IRF3

Molecular functions related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor I binding GO:0031994 9.4 ITGAV ITGB3
2 virion binding GO:0046790 9.37 CD209 CLEC4M
3 coreceptor activity GO:0015026 9.33 CCR5 ITGAV ITGB3
4 C-X3-C chemokine binding GO:0019960 9.32 ITGAV ITGB3
5 neuregulin binding GO:0038132 9.26 ITGAV ITGB3
6 double-stranded RNA binding GO:0003725 9.26 DDX58 IFIH1 OAS1 TLR3
7 virus receptor activity GO:0001618 9.02 CCR5 CD209 CLEC4M ITGAV ITGB3
8 protein binding GO:0005515 10.34 CCR5 CD209 CFH DDX58 EXOC1 IFIH1

Sources for West Nile Virus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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