West Nile Virus disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

WNV MCID: WST005 MIFTS: 54	West Nile Virus (WNV) Categories: Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

Sources

Aliases & Classifications for West Nile Virus

MalaCards integrated aliases for West Nile Virus:

Name: West Nile Virus ⁵⁶ ⁷⁴ ⁴²

West Nile Virus, Susceptibility to ⁵⁶ ²⁹ ¹³ ⁶ ³⁹

Encephalitis, West Nile Fever ⁷¹

West Nile Viral Infection ⁷¹

Wnv, Susceptibility to ⁵⁶

West-Nile Encephalitis ⁵⁸

West Nile Fever ⁷¹

West-Nile Fever ⁵⁸

Wnv ⁵⁶

Characteristics:

Orphanet epidemiological data:

⁵⁸

west-nile encephalitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Genetic diseases Infectious diseases Rare diseases
Anatomical: Neuronal diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Certain infectious and parasitic diseases

Arthropod-borne viral fevers and viral haemorrhagic fevers

Other mosquito-borne viral fevers

West Nile virus infection

Orphanet: ⁵⁸

Rare neurological diseases

Rare infectious diseases

External Ids:

OMIM ⁵⁶ 610379

ICD10 via Orphanet ³³ A92.3

UMLS via Orphanet ⁷² C0043124 C0751583

Orphanet ⁵⁸ ORPHA83476

UMLS ⁷¹ C0043124 C0751583 C1096184

Sources

Summaries for West Nile Virus

MedlinePlus : ⁴² West Nile virus (WNV) is an infectious disease that first appeared in the United States in 1999. Infected mosquitoes spread the virus that causes it. People who get WNV usually have no symptoms or mild symptoms. The symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. They can last a few days to several weeks, and usually go away on their own. If West Nile virus enters the brain, however, it can be life-threatening. It may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. A physical exam, medical history, and laboratory tests can diagnose it. Older people and those with weakened immune systems are most at risk. There are no specific vaccines or treatments for human WNV disease. The best way to avoid WNV is to prevent mosquito bites: Use insect repellent Get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels Stay indoors between dusk and dawn, when mosquitoes are most active Use screens on windows to keep mosquitoes out

MalaCards based summary : West Nile Virus, also known as west nile virus, susceptibility to, is related to west nile virus infection and west nile fever, and has symptoms including seizures, fever and pruritus. An important gene associated with West Nile Virus is CCR5 (C-C Motif Chemokine Receptor 5), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Maraviroc and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related phenotype is Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection.

OMIM : ⁵⁶ WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle between avian hosts and mosquito vectors. The virus was first isolated from a Ugandan woman in 1937 and subsequently emerged in Europe and, in 1999, in New York, with eventual spread throughout North America. WNV causes a spectrum of disease ranging from acute fever to lethal encephalitis. Susceptibility to WNV is increased in the elderly and in immunocompromised individuals (summary by Diamond and Klein (2006) and Glass et al. (2005)). (610379)

Wikipedia : ⁷⁴ West Nile virus (WNV) is a single-stranded RNA virus that causes West Nile fever. It is a member of the... more...

Sources

Related Diseases for West Nile Virus

Diseases related to West Nile Virus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 290)

#	Related Disease	Score	Top Affiliating Genes
1	west nile virus infection	35.2	IRF3 CCR5
2	west nile fever	33.9	CLEC4M CD209 CCR5
3	west nile encephalitis	33.4	CLEC4M CCR5
4	yellow fever	31.2	SPCS1 RSAD2 CCR5
5	chikungunya	31.0	RSAD2 DDX58 CD209
6	rift valley fever	30.5	IFITM3 IFITM2 IFITM1 CD209
7	japanese encephalitis	30.4	SPCS1 RSAD2 IFNA1 CLEC4M CD209
8	avian influenza	30.2	IFNA1 DDX58 CCR5
9	encephalitis	30.0	SPCS1 RSAD2 IRF3 IFNA1 DDX58 CLEC4M
10	tick-borne encephalitis	30.0	RSAD2 IFNA1 DDX58 CD209 CCR5
11	newcastle disease	30.0	IRF3 IFNA1 DDX58
12	rabies	29.9	IRF3 IFNA1 DDX58
13	human immunodeficiency virus type 1	29.7	IRF3 CLEC4M CD209 CCR5AS CCR5
14	dengue shock syndrome	29.6	IFNA1 CLEC4M CD209
15	dengue virus	29.5	RSAD2 IFITM3 IFITM2 IFITM1 IFIH1 EXOC1
16	measles	29.4	IRF3 IFNA1 IFIH1 DDX58 CD209
17	viral infectious disease	29.3	IRF3 IFNA1 IFIH1 DDX58 CLEC4M CD209
18	stomatitis	29.2	RSAD2 IFNA1 IFITM3 IFITM2 DDX58
19	severe acute respiratory syndrome	29.2	IRF3 IFNA1 IFIH1 DDX58 CLEC4M CD209
20	mouth disease	29.0	ITGAV IRF3 IFNA1 IFIH1 DDX58
21	hepatitis c	28.9	RSAD2 IRF3 IFNA1 DDX58 CLEC4M CCR5
22	hepatitis c virus	28.8	SPCS1 RSAD2 IRF3 IFITM3 IFITM1 DDX58
23	thrombocytopenia	28.6	ITGB3 IFNA1 IFIH1 CFH CD209
24	herpes simplex	28.5	ITGAV IRF3 IFNA1 IFIH1 DDX58 CD209
25	influenza	27.6	RSAD2 IRF3 IFNA1 IFITM3 IFITM2 IFITM1
26	west nile virus encephalitis	13.0
27	kunjin encephalitis	11.6
28	acute flaccid myelitis	11.6
29	meningoencephalitis	11.0
30	st. louis encephalitis	10.9
31	viral encephalitis	10.9
32	poliomyelitis	10.8
33	exanthem	10.8
34	triiodothyronine receptor auxiliary protein	10.7
35	meningitis	10.7
36	tremor	10.7
37	ataxia and polyneuropathy, adult-onset	10.7
38	chorioretinitis	10.7
39	aseptic meningitis	10.7
40	myocarditis	10.7
41	meningitis and encephalitis	10.6
42	myelitis	10.6
43	multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	10.6
44	eastern equine encephalitis	10.6
45	pica disease	10.6
46	murray valley encephalitis	10.5
47	guillain-barre syndrome	10.5
48	vasculitis	10.5
49	myoclonus	10.5
50	neuritis	10.5

Graphical network of the top 20 diseases related to West Nile Virus:

Sources

Symptoms & Phenotypes for West Nile Virus

Clinical features from OMIM:

610379

UMLS symptoms related to West Nile Virus:

seizures, fever, pruritus, tremor, back pain, headache, syncope, pain, chronic pain, sciatica, vertigo/dizziness, sleeplessness

GenomeRNAi Phenotypes related to West Nile Virus according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection	GR00233-A-1	8.32	IFIH1

Sources

Drugs & Therapeutics for West Nile Virus

Drugs for West Nile Virus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Maraviroc

Approved, Investigational

Phase 4

376348-65-1

3002977

Synonyms:

376348-65-1

4,4-difluoro-N-((1S)-3-(exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide

4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide

4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide

674782-29-7

AC1MHEFQ

AC-558

Celsentri

Celsentri(TM)

CHEBI:537583

CHEMBL1201187

CHEMBL256907

CID3002977

DB04835

exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide

Isopropyl, 4,4-difluoro-N-((1S)-3-{(1R,3s,5S)-3-(3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)octan-8-yl}-1-phenylpropyl)cyclohexanecarboxamide

LS-182818

maraviroc

Maraviroc

Maraviroc [USAN]

Maravirocum

MVC

Pfizer brand OF maraviroc

PRO 140 & Maraviroc

PRO 140 (Anti-CCR5 monoclonal antibody) & exo-4,4-Difluoro-N-[3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1(S)-phenylpropyl]cyclohexanecarboxamide

Selzentry

Selzentry(TM)

UK 427857

UK-427,857

UK-427,857 maraviroc (MVC)

UK-427857

UNII-MD6P741W8A

Vaccines

Phase 4

Antiviral Agents

Phase 4

Anti-Infective Agents

Phase 4

Anti-HIV Agents

Phase 4

Anti-Retroviral Agents

Phase 4

Hydroxychloroquine

Approved

Phase 2, Phase 3

118-42-3

3652

Synonyms:

(+-)-Hydroxychloroquine

(±)-hydroxychloroquine

118-42-3

2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol

2-((4-((7-chloro-4-Quinolyl)amino)pentyl)ethylamino)ethanol

2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol

2-(N-(4-(7-chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol

2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol

2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol

2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol

5-22-10-00280 (Beilstein Handbook Reference)

747-36-4 (sulfate (1:1) salt)

7-chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline

7-chloro-4-(4-(Ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline

7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline

7-chloro-4-(4-(N-Ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline

7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline

7-chloro-4-(4-(N-Ethyl-N-b-hydroxyethylamino)-1-methylbutylamino)quinoline

7-chloro-4-(4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino)quinoline

7-chloro-4-(4-(N-Ethyl-N-β-hydroxyethylamino)-1-methylbutylamino)quinoline

7-Chloro-4-(5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl)aminoquinoline

7-chloro-4-[4-(N-Ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline

7-chloro-4-[4-(N-Ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline

7-chloro-4-[4-(N-ethyl-N-β-hydroxyethylamino)-1-methylbutylamino]quinoline

7-chloro-4-[4-(N-Ethyl-N-β-hydroxyethylamino)-1-methylbutylamino]quinoline

7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline

7-chloro-4-[5-(N-Ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline

AC1L1GEW

Axemal

BRN 0253894

C07043

C18H26ClN3O

CHEMBL1535

CID3652

D08050

DB01611

DivK1c_000942

Dolquine

EINECS 204-249-8

Ercoquin

Gen-Hydroxychloroquine 200mg Tablets

HCQ

Hidroxicloroquina

Hidroxicloroquina [inn-spanish]

Hidroxicloroquina [INN-Spanish]

HMS502P04

Hydroxychlorochin

Hydroxychloroguine

hydroxychloroquine

Hydroxychloroquine

Hydroxychloroquine (INN)

Hydroxychloroquine [INN:BAN]

Hydroxychloroquine sulfate

Hydroxychloroquine sulfate (1:1) salt

Hydroxychloroquine Sulfate (1:1) Salt

Hydroxychloroquinum

Hydroxychloroquinum [inn-latin]

Hydroxychloroquinum [INN-Latin]

IDI1_000942

Idrossiclorochina

Idrossiclorochina [dcit]

Idrossiclorochina [DCIT]

KBio1_000942

LS-66614

MolPort-003-847-792

NCGC00159483-02

NINDS_000942

NSC4375

Oxichlorochine

Oxichlorochinum

Oxichloroquine

Oxychlorochin

Oxychloroquine

PlaqueN/A

Plaquenil

Polirreumin

Polirreumin (TN)

Quensyl

SPBio_001116

Spectrum2_001238

Spectrum5_001697

ST072188

UNII-4QWG6N8QKH

WIN 1258

Nitazoxanide

Approved, Investigational, Vet_approved

Phase 2, Phase 3

55981-09-4

41684

Synonyms:

(2-((5-Nitro-2-thiazolyl)carbamoyl)phenyl)acetat

[2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl] acetate

2-(Acetolyloxy)-N-(5-nitro-2-thiazolyl)benzamide

2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate

2-Acetyloxy-N-[(5-nitro-2-thiazolyl)]benzamide

55981-09-4

AC-1302

AC1L26A1

AC1Q5NVY

Alinia

Alinia (TN)

AZT + Nitazoxanide

azt+ nitazoxanide

BRN 1225475

C12H9N3O5S

CHEMBL1401

CID41684

Colufase

Columbia brand 1 OF nitazoxanide

Columbia brand 2 OF nitazoxanide

Columbia brand 3 OF nitazoxanide

CPD000466367

Cryptaz

D02486

Daxon

Daxon, Dexidex, Kidonax, Pacovanton, Paramix, Nitax, Zox, Nitazoxanide

DB00507

EINECS 259-931-8

FT-0082459

Heliton

HMS2051L04

I14-6011

LS-144176

MLS000759492

MLS001424074

MolPort-002-042-244

N-(5-Nitro-2-thiazolyl)salicylamide acetate (ester)

N-(5-Nitrothiazol-2-yl)salicylamide acetate ester

NCGC00090774-01

NCI60_034935

NCIMech_000843

Nitaxozanid

Nitaxozanide

Nitazoxanid

Nitazoxanida

Nitazoxanida [INN-Spanish]

Nitazoxanide

NITAZOXANIDE

Nitazoxanide (USAN/INN)

Nitazoxanide [USAN:INN]

Nitazoxanidum

Nitazoxanidum [INN-Latin]

NSC 697855

NSC697855

NTZ

o-(N-(5-Nitrothiazol-2-yl)carbamoyl)phenyl acetate

Oprea1_263587

Phavic-1

Romark brand 1 OF nitazoxanide

Romark brand 2 OF nitazoxanide

S1627_Selleck

Salicylamide, N-(5-nitro-2-thiazolyl)- acetate (ester)

Salicylamide, N-(5-nitro-2-thiazolyl)-, acetate (ester)

SAM001246708

SBB068315

SMR000466367

STK395664

Taenitaz

Tizoxanide glucuronide

UNII-SOA12P041N

ZINC03956788

Ivermectin

Approved, Investigational, Vet_approved

Phase 2, Phase 3

70288-86-7

6474909

Synonyms:

(2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside

71827-03-7

AB00513813

AC1MJ4GR

AC1N7O27

BPBio1_000322

BRD-K24652731-001-02-7

BSPBio_000292

CHEMBL341047

CID11957587

CID4330618

CID6321424

CID6419971

CID6427057

EU-0100693

FT-0082656

HMS1568O14

HMS2089M09

I 8898

I8898_SIGMA

Ivermectin

IVERMECTIN

Ivermectina

Ivermectine

Ivermectinum

Lopac0_000693

MK-933

MLS001333247

MLS001333248

MLS002153248

MolPort-006-394-715

NCGC00094047-01

NCGC00094047-02

NCGC00094047-03

Prestwick_516

Prestwick2_000156

Prestwick3_000156

S1351_Selleck

SMR000857211

Antiprotozoal Agents

Phase 2, Phase 3

Antiparasitic Agents

Phase 2, Phase 3

Antimalarials

Phase 2, Phase 3

Antirheumatic Agents

Phase 2, Phase 3

Ribavirin

Approved

Phase 2

36791-04-5

37542

Synonyms:

1-.beta.-D-Ribofuranosyl-1,2,4-triazolo-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide

1-b-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

1-b-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

1-beta-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide

1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide

1-β-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide

36791-04-5

437710-49-1

66510-90-5

AA-504/07617051

AB00430481

AC1L1XXZ

AC1Q1IDC

AC1Q4ZGS

AKOS001715163

BB_NC-0567

BPBio1_001195

BRN 0892462

BSPBio_001085

BSPBio_003352

CHEMBL1643

CID37542

Copegus

Copegus (TN)

Cotronak

C-Virin

D00423

DB00811

Dermatech brand OF ribavirin

DivK1c_000782

DRG-0028

Drug: Ribavirin

Essex brand OF ribavirin

EU-0101063

FT-0082885

Grossman brand OF ribavirin

HMS2090L15

HMS2094O09

HMS502H04

HSDB 6513

ICN brand OF ribavirin

ICN-1229

IDI1_000782

KBio1_000782

KBio2_002328

KBio2_004896

KBio2_007464

KBio3_002854

KBioGR_001804

KBioSS_002331

KS-1104

Lopac0_001063

LS-1241

Merck brand OF ribavirin

MLS000028486

MLS002222317

MolPort-002-507-104

MolPort-002-885-856

NCGC00090726-01

NCGC00090726-03

NCGC00090726-04

NCGC00090726-05

NCGC00090726-06

NCGC00090726-07

NINDS_000782

NSC 163039

NSC163039

Pfizer brand OF ribavirin

Prestwick3_000993

R 9644

R-964

R9644_SIGMA

Ravanex

RBV

Rebetol

Rebetol (TN)

Rebetron

Rebretron

RG-964

Ribacine

Ribamide

Ribamidil

Ribamidyl

Ribasphere

Ribasphere (TN)

Ribav

RIBAV

ribavirin

Ribavirin

Ribavirin (JAN/USP/INN)

Ribavirin [USAN:INN]

Ribavirin Capsules

Ribavirin merck brand

Ribavirin Triphosphate

Ribavirina

Ribavirina [INN-Spanish]

Ribavirine

Ribavirine [INN-French]

Ribavirin-TP

Ribavirinum

Ribavirinum [INN-Latin]

Ribovirin

Ro 20-9963/000

Ro-20-9963

RTC

RTCA

RTP

S2504_Selleck

SCH 18908

SMP1_000261

SMR000058315

Spectrum_001826

SPECTRUM1503938

Spectrum3_001876

Spectrum4_001252

Spectrum5_002075

SR-01000076112-3

Three rivers pharmaceuticals brand OF ribavirin

Tribavirin

UNII-49717AWG6K

Varazid

Vilona

Viramid

Viramide

Virazid

Virazide

Virazole

Virazole (Ribavirin) Inhalation Solution

Virazole (TN)

Virazole 5'-triphosphate

ZINC01035331

Sargramostim

Approved, Investigational

Phase 2

83869-56-1, 123774-72-1

Synonyms:

123774-72-1

D05803

Leukine

Leukine (TN)

Recombinant human granulocyte-macrophage colony stimulating factor

rGM-CSF

rHu GM-CSF

Sargramostim

Sargramostim (genetical recombination)

Sargramostim (genetical recombination) (JAN)

Sargramostim (USAN/INN)

Glycine

Approved, Nutraceutical, Vet_approved

Phase 1, Phase 2

56-40-6

750

Synonyms:

(1-13c)glycinato

(15N)Glycine

15527_RIEDEL

15527_SIAL

15743-44-9 (mono-potassium salt)

17829-66-2 (cobalt salt)

18875-39-3

2,2-dialkylglycines

2311-65-1

25718-94-9

29728-27-6 (monoammonium salt)

2-Aminoacetate

2-Aminoacetic acid

32817-15-5 (copper salt)

33226_RIEDEL

33226_SIAL

33242-26-1 (calcium salt)

35947-07-0 (calcium salt (2:1))

410225_SIAL

50046_FLUKA

50046_SIGMA

513-29-1 (sulfate (3:1))

52955-63-2

56-40-6

57678-19-0

6000-43-7 (hydrochloride)

6000-44-8 (mono-hydrochloride salt)

63183-41-5 (hydrochloride hydrogen carbonate)

71295-98-2 (phosphate (1:1))

7490-95-1 (hydrochloride (2:1)

7490-95-1 (hydrochloride (2:1))

7575-55-5

848646-45-7

87867-94-5

AB1002628

AB-131/40217813

AC1L19XW

AC1Q28JW

AC1Q53O0

Acid, aminoacetic

Acide aminoacetique

Acide aminoacetique [INN-French]

Acido aminoacetico

Acido aminoacetico [INN-Spanish]

Acidum aminoaceticum

Acidum aminoaceticum [INN-Latin]

Aciport

AI3-04085

AKOS000119626

amino-Acetate

Aminoacetate

aminoacetic acid

amino-Acetic acid

Aminoacetic acid

AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER

Aminoazijnzuur

Aminoessigsaeure

Aminoessigsäure

Aminoethanoate

Aminoethanoic acid

Amitone

an alpha amino acid ester

AR-1A0345

AR-1A0532

B72BA06C-60E9-4A83-A24A-A2D7F465BB65

Biomol-NT_000195

bmse000089

BPBio1_001222

C00037

Calcium salt glycine

CCRIS 5915

CHEBI:15428

CHEBI:15705

CHEBI:16228

CHEMBL773

CID750

Cobalt salt glycine

Copper salt glycine

Corilin

CPD-8569

D00011

DB00145

EINECS 200-272-2

FEMA No. 3287

FT-0083159

G0099

G0317

G5417_SIGMA

G5523_SIGMA

G7126_SIGMA

G7403_SIGMA

G8790_SIGMA

G8898_SIGMA

Glicina

Glicina [INN-Spanish]

Glicoamin

gly

Gly

GLY (IUPAC abbrev)

Glycin

glycine

Glycine

Glycine (JP15/USP)

Glycine [INN]

GLYCINE 1.5% IN PLASTIC CONTAINER

Glycine carbonate (1:1), monosodium salt

Glycine carbonate (2:1), monolithium salt

Glycine carbonate (2:1), monopotassium salt

Glycine carbonate (2:1), monosodium salt

Glycine hydrochloride

Glycine hydrochloride (2:1)

Glycine iron sulphate (1:1)

Glycine phosphate

Glycine phosphate (1:1)

Glycine sulfate (3:1)

GLYCINE, ACS

Glycine, calcium salt

Glycine, calcium salt (2:1)

Glycine, cobalt salt

Glycine, copper salt

Glycine, homopolymer (VAN)

Glycine, labeled with carbon-14

Glycine, monoammonium salt

Glycine, monopotasssium salt

Glycine, monosodium salt

Glycine, non-medical

Glycine, sodium hydrogen carbonate

Glycine-UL-14C hydrochloride

Glycinum

Glycinum [INN-Latin]

Glycocoll

Glycolixir

Glycosthene

Glykokoll

Glyzin

Gyn-hydralin

H2N-CH2-COOH

Hampshire glycine

Hgly

H-Gly-OH

HSDB 495

Hydrochloride, glycine

InChI=1/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5

KST-1A2919

KST-1A8102

L001246

L-alpha-amino acids

Leimzucker

L-Glycine

LS-218

MolPort-000-871-607

Monoammonium salt glycine

Monopotasssium salt glycine

Monosodium salt glycine

NCGC00024503-01

NCGC00024503-02

nchem.554-comp2

nchembio.121-comp9

nchembio.145-comp33

nchembio.198-comp12

NChemBio.2007.13-comp1

nchembio.265-comp9

nchembio.266-comp30

NSC 25936

NSC25936

P8791_SIGMA

Padil

Phosphate, glycine

polyglycine

Polyglycine II

S04-0135

Salt glycine, monoammonium

Salt glycine, monosodium

Sucre de gelatine

Tocris-0219

UNII-TE7660XO1C

W328707_ALDRICH

WLN: Z1VQ

Molgramostim

Investigational

Phase 2

99283-10-0

Antimetabolites

Phase 2

Pharmaceutical Solutions

Phase 2

Rho(D) Immune Globulin

Phase 2

gamma-Globulins

Phase 2

Immunoglobulins, Intravenous

Phase 2

Immunoglobulin G

Phase 2

Immunoglobulins

Phase 2

Antibodies

Phase 2

Antibodies, Monoclonal

Phase 2

Immunologic Factors

Phase 2

Aluminum sulfate

Approved

Phase 1

10043-01-3

Aluminum hydroxide

Approved, Investigational

Phase 1

21645-51-2

Interventional clinical trials:

(show all 41)

#	Name	Status	NCT ID	Phase	Drugs
1	Randomised, Placebo Controlled, Phase IV, Safety and Exploratory Immunogenicity Study on Maraviroc, an Oral ART CCR5 Inhibitor, on the Intensification of Immune Function in HIV-1 Infected Subjects Receiving Immunisation With Novel Antigens	Terminated	NCT01049204	Phase 4	Maraviroc;placebo
2	Efficacy and Safety of Hydroxychloroquine and Ivermectin in Hospitalized no Critical Patients Secondary to COVID-19 Infection: Randomized Controlled Trial	Recruiting	NCT04391127	Phase 3	Hydroxychloroquine;Ivermectin;Placebo
3	Treatment of Covid-19 With Favipiravir Versus Hydroxychloroquine: a Randomized Comparator Trial	Not yet recruiting	NCT04387760	Phase 2, Phase 3	Hydroxychloroquine;Favipiravir
4	Clinical Trial Evaluating Safety and Efficacy of Ivermectin and Nitazoxanide Combination as Adjuvant Therapy in COVID-19 Newly Diagnosed Egyptian Patients: A Tanta University Hope	Not yet recruiting	NCT04360356	Phase 2, Phase 3
5	Treatment of Japanese Encephalitis - a Double Blind Placebo Controlled Trial	Unknown status	NCT00216268	Phase 2	Ribavirin
6	Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults.	Completed	NCT00746798	Phase 2
7	Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults	Completed	NCT00442169	Phase 2
8	A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (Omr-IgG-am) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus(WNV)	Completed	NCT00069316	Phase 2	Omr-IgG-am
9	A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (OMR-IGG-AM) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus (WNV) Encephalitis and/or Myelitis	Completed	NCT00068055	Phase 1, Phase 2	Omr-lgG-am;Polygam® S/D;Placebo
10	A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal	Completed	NCT01856205	Phase 2	Intravenous immunoglobulin [ImmunoRel™ (batch 20081217)]
11	Most Closely HLA Matched Allogeneic Virus Specific Cytotoxic T-Lymphocytes (CTL) to Treat Persistent Reactivation Or Infection With Adenovirus, CMV and EBV After Hemopoietic Stem Cell Transplantation (HSCT)	Completed	NCT00711035	Phase 1, Phase 2
12	Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus	Terminated	NCT00927953	Phase 2
13	Phase II Trial of ID-Specific Donor Vaccinated Lymphocyte Infusion for Patients With Myeloma Relapsing or Failing to Achieve a Complete Remission After an Allogenic Transplant	Terminated	NCT01174082	Phase 2	GM-CSF
14	Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis	Completed	NCT00537147	Phase 1
15	Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis	Completed	NCT00094718	Phase 1
16	A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects	Completed	NCT00300417	Phase 1	VRC-WNVDNA020-00-VP
17	A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers	Completed	NCT00106769	Phase 1	VRC-WNVDNA017-00-VP
18	Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3´Δ30 Chimeric Virus Vaccine (WN/DEN4Δ30), a Live Attenuated Vaccine for West Nile Encephalitis, in Flavivirus-naïve Adults 50-65 Years of Age	Completed	NCT02186626	Phase 1
19	A Double Blind, Randomized, Placebo-Controlled, Phase I Dose Escalation Trial to Evaluate the Safety and Immunogenicity of an Inactivated West Nile Virus Vaccine, HydroVax-001, in Healthy Adults	Completed	NCT02337868	Phase 1
20	Phase 1, Open-Label, Safety Study of HBV-002 (West Nile Recombinant Subunit Vaccine) in Healthy Adults	Completed	NCT00707642	Phase 1
21	Pharmacokinetic Study of AVI-4020 in Cerebral Spinal Fluid Among Healthy Adult Males Following Intravenous Administration	Completed	NCT00387283	Phase 1	AVI-4020 Injection
22	A Phase 1, Randomized, Double-Blind, Dose-Escalation Cohort Study to Evaluate the Safety, Tolerability and Pharmacokinetics of a Single Intravenous Infusion of MGAWN1, a Neutralizing, Humanized, Monoclonal Antibody (IgG1k) to West Nile Virus, in Healthy Adults	Completed	NCT00515385	Phase 1	MGAWN1;MGAWN1
23	Pharmacokinetic Study of AVI-4065 in Cerebral Spinal Fluid Among Healthy Adult Males Following Subcutaneous Administration	Completed	NCT00381433	Phase 1	AVI-4065 Injection
24	Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study in Healthy Volunteers to Evaluate the Safety and Immunogenicity of AGS-v, a Universal Mosquito-Borne Disease Vaccine	Completed	NCT03055000	Phase 1
25	An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease	Terminated	NCT00091845	Phase 1	AVI-4020 Injection
26	Assessment of the Impact of Notification of Blood Donors Testing Positive for Microbiology Markers: What is the Psychological Impact of Notification and Does the Method of Notification Influence the Outcome?	Unknown status	NCT01050881
27	Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease	Completed	NCT00069303
28	Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease	Completed	NCT00138463
29	Surveillance of Summer Febrile Syndromes of Viral Origin in South of France	Completed	NCT00842166
30	VRC 300: Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases	Completed	NCT00068926
31	Retrovirus Epidemiology Donor Study-II (REDS-II)	Completed	NCT00097006
32	Pilot Study to Detect DENGUE Virus in Sperm.	Completed	NCT03612609
33	Organ Transplant Infection Prevention and Detection Project 1.0; Cohort Study of Transplant Recipients at "Ultra-High" Risk for Invasive Fungal Infections	Completed	NCT00177801
34	Clinical Evaluation of the FilmArray® Global Fever (GF) Panel	Recruiting	NCT02968355
35	Descriptive and Prognostic Study of Arbovirus Infections in France, Based on a Hospital Cohort of Children and Adults With Suspected Arbovirose.r	Recruiting	NCT01099852
36	Autologous Ovarian Tissue Transplantation	Recruiting	NCT03496636
37	The Collection and Storage of Umbilical Cord Blood for Transplantation	Recruiting	NCT01728545
38	The Threat of Infectious Encephalitis in Southeast Asia: SouthEast Asia Encephalitis Project	Active, not recruiting	NCT04089436
39	Cell Harvest and Preparation for Surgery Branch Adoptive Cell Therapy Protocols	Enrolling by invitation	NCT00068003
40	Prospective Investigation of Oxidative Stress in West Nile Virus Infection	Not yet recruiting	NCT04371003
41	Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus	No longer available	NCT01206504

Search NIH Clinical Center for West Nile Virus

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Ribavirin

Sources

Genetic Tests for West Nile Virus

Genetic tests related to West Nile Virus:

#	Genetic test	Affiliating Genes
1	West Nile Virus, Susceptibility to ²⁹	CCR5

Sources

Anatomical Context for West Nile Virus

MalaCards organs/tissues related to West Nile Virus:

⁴⁰

Testes, Brain, T Cells, Spinal Cord, Skin, B Cells, Kidney

Sources

Publications for West Nile Virus

Articles related to West Nile Virus:

(show top 50) (show all 6349)

#	Title	Authors	PMID	Year
1	CCR5 deficiency increases risk of symptomatic West Nile virus infection. ⁶ ⁵⁶ ⁶¹	Glass WG...Murphy PM	16418398	2006
2	A complement-microglial axis drives synapse loss during virus-induced memory impairment. ⁶¹ ⁵⁶	Vasek MJ...Klein RS	27337340	2016
3	Host genetic risk factors for West Nile virus infection and disease progression. ⁶¹ ⁵⁶	Bigham AW...Bamshad M	21935451	2011
4	Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis. ⁶¹ ⁵⁶	Lim JK...Murphy PM	21131425	2011
5	Tregs control the development of symptomatic West Nile virus infection in humans and mice. ⁶¹ ⁵⁶	Lanteri MC...Norris PJ	19855131	2009
6	Key role of T cell defects in age-related vulnerability to West Nile virus. ⁶¹ ⁵⁶	Brien JD...Nikolich-Zugich J	19901080	2009
7	Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. ⁵⁶ ⁶¹	Lim JK...Murphy PM	19247438	2009
8	Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. ⁶¹ ⁵⁶	Town T...Fikrig E	19200759	2009
9	Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. ⁵⁶ ⁶¹	Arjona A...Bucala R	17909632	2007
10	A genetic basis for human susceptibility to West Nile virus. ⁶¹ ⁵⁶	Diamond MS...Klein RS	16750369	2006
11	Protective immune responses against West Nile virus are primed by distinct complement activation pathways. ⁶¹ ⁵⁶	Mehlhop E...Diamond MS	16651386	2006
12	Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. ⁵⁶ ⁶¹	Glass WG...Murphy PM	16230476	2005
13	Clinical Quandaries Posed by Concurrent Human Immunodeficiency Virus (HIV) and West Nile Virus (WNV) infections: Case Report. ⁴² ⁶¹	Momah T...Mbride N	32150640	2020
14	West Nile virus capsid protein inhibits autophagy by AMP-activated protein kinase degradation in neurological disease development. ⁶¹ ⁴²	Kobayashi S...Kariwa H	31971978	2020
15	Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. ⁶	Thio CL...Carrington M	19017985	2008
16	The geographic spread of the CCR5 Delta32 HIV-resistance allele. ⁶	Novembre J...Slatkin M	16216086	2005
17	The case for selection at CCR5-Delta32. ⁶	Sabeti PC...Lander ES	16248677	2005
18	The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. ⁶	Goulding C...Kelleher D	15863470	2005
19	Reappraisal of the historical selective pressures for the CCR5-Delta32 mutation. ⁶	Duncan SR...Duncan CJ	15744032	2005
20	A mutated CCR5 gene may have favorable prognostic implications in MS. ⁶	Kantor R...Achiron A	12874407	2003
21	Absence of the HIV-1 protective Delta ccr5 allele in most ethnic populations of India. ⁶	Majumder PP...Dey B	11781692	2001
22	The coreceptor mutation CCR5Delta32 influences the dynamics of HIV epidemics and is selected for by HIV. ⁶	Sullivan AD...Kirschner D	11517319	2001
23	Chemokine receptor polymorphism in transplantation immunology: no longer just important in AIDS. ⁶	Strieter RM...Belperio JA	11403804	2001
24	CC chemokine receptor 5 and renal-transplant survival. ⁶	Fischereder M...Schlondorff D	11403814	2001
25	Delta 32 deletion of CCR5 gene and association with asthma or atopy. ⁶	Mitchell TJ...Cookson WO	11081537	2000
26	CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group. ⁶	Barcellos LF...Oksenberg JR	10803840	2000
27	Prevalence of CCR5delta32 in allergic diseases. ⁶	Szalai C...Falus A	10615909	2000
28	Association of CCR5 delta32 with reduced risk of asthma. ⁶	Hall IP...Helms PJ	10520641	1999
29	Distribution of the CCR5 gene 32-bp deletion in Europe. ⁶	Lucotte G...Mercier G	9768627	1998
30	Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. ⁶	Stephens JC...Dean M	9585595	1998
31	Mutational analysis of the CCR5 and CXCR4 genes (HIV-1 co-receptors) in resistance to HIV-1 infection and AIDS development among intravenous drug users. ⁶	Alvarez V...Coto E	9600249	1998
32	The deltaccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe. ⁶	Libert F...Vassart G	9466996	1998
33	First report of a healthy Indian heterozygous for delta 32 mutant of HIV-1 co-receptor-CCR5 gene. ⁶	Husain S...Banerjea A	9511755	1998
34	The extent of genetic variation in the CCR5 gene. ⁶	Ansari-Lari MA...Gibbs RA	9207783	1997
35	Global distribution of the CCR5 gene 32-basepair deletion. ⁶	Martinson JJ...Clegg JB	9140404	1997
36	HIV-1 infection in an individual homozygous for the CCR5 deletion allele. ⁶	Biti R...Liang T	9055842	1997
37	Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. ⁶	Zimmerman PA...Murphy PM	9132277	1997
38	Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. ⁶	Liu R...Landau NR	8756719	1996
39	Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. ⁶	Samson M...Parmentier M	8751444	1996
40	Fatal case of West Nile encephalitis associated with acute anteroseptal ST elevation myocardial infarction (STEMI): a case report. ⁴²	Sabadi D...Vilibic-Cavlek T	32334492	2020
41	Evidence of West Nile virus infection in migratory and resident wild birds in west coast of peninsular Malaysia. ⁶¹	Ain-Najwa MY...Mohd-Kharip-Shah AK	32405525	2020
42	Personalized adapted locomotor training for an individual with sequelae of West Nile virus infection: a mixed-method case report. ⁶¹	Unger J...Musselman KE	30136877	2020
43	Nontransient third-degree heart block and persistent respiratory findings as sequelae of acute occupational exposure to pyrethroids insecticide. ⁶¹	Alexandri M...Spaeth KR	32297674	2020
44	Infectious and Autoimmune Causes of Encephalitis in Children. ⁶¹	Erickson TA...Murray KO	32358069	2020
45	Feeding Habits of Vector Mosquitoes in Harris County, TX, 2018. ⁶¹	Mann JG...Pitts RJ	32574364	2020
46	West Nile Virus-associated Hospitalizations, California, USA, 2004-2017. ⁶¹	Snyder RE...Vugia DJ	32525967	2020
47	A Molecular Determinant of West Nile Virus Secretion and Morphology as a Target for Viral Attenuation. ⁶¹	Basset J...Pardigon N	32269117	2020
48	West Nile virus lineage 2 in humans and mosquitoes in Bulgaria, 2018-2019. ⁶¹	Christova I...Mikov O	32305885	2020
49	An unusual case of unilateral chorioretinitis and blind spot enlargement associated with asymptomatic West Nile virus infection. ⁶¹	Sanz G...Oliver AL	32373759	2020
50	Landscape and demographic determinants of Culex infection with West Nile virus during the 2012 epidemic in Dallas County, TX. ⁶¹	Poh KC...Hamer GL	32370939	2020

Sources

Genes for West Nile Virus

Genes related to West Nile Virus (1 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	675.69	Molecular basis known ⁵⁶ Genetic Tests ²⁹ Susceptibility factor ⁵⁶ GeneCards inferred via : Publications Proteins Variants (show sections)
2	CLEC4M	C-Type Lectin Domain Family 4 Member M	Protein Coding	35.77	GeneCards inferred via : Publications Summaries Proteins Functions (show sections)
3	IFITM3	Interferon Induced Transmembrane Protein 3	Protein Coding	26.25	GeneCards inferred via : Publications Summaries Functions (show sections)
4	CD209	CD209 Molecule	Protein Coding	25.1	GeneCards inferred via : Publications Proteins Functions (show sections)
5	ITGB3	Integrin Subunit Beta 3	Protein Coding	25.1	GeneCards inferred via : Publications Proteins Functions (show sections)
6	ITGAV	Integrin Subunit Alpha V	Protein Coding	24.88	GeneCards inferred via : Publications Proteins Functions (show sections)
7	MKRN1	Makorin Ring Finger Protein 1	Protein Coding	16.79	GeneCards inferred via : Publications Summaries (show sections)
8	SPCS1	Signal Peptidase Complex Subunit 1	Protein Coding	16.16	GeneCards inferred via : Proteins Functions (show sections)
9	DDX58	DExD/H-Box Helicase 58	Protein Coding	15.94	GeneCards inferred via : Publications Functions (show sections)
10	IRF3	Interferon Regulatory Factor 3	Protein Coding	15.84	GeneCards inferred via : Publications Functions (show sections)
11	IFITM2	Interferon Induced Transmembrane Protein 2	Protein Coding	15.76	GeneCards inferred via : Publications Functions (show sections)
12	CFH	Complement Factor H	Protein Coding	15.58	GeneCards inferred via : Publications Proteins (show sections)
13	EXOC1	Exocyst Complex Component 1	Protein Coding	15.58	GeneCards inferred via : Publications Proteins (show sections)
14	IFIH1	Interferon Induced With Helicase C Domain 1	Protein Coding	15.51	GeneCards inferred via : Publications Functions (show sections)
15	IFITM1	Interferon Induced Transmembrane Protein 1	Protein Coding	15.51	GeneCards inferred via : Publications Functions (show sections)
16	RSAD2	Radical S-Adenosyl Methionine Domain Containing 2	Protein Coding	15.51	GeneCards inferred via : Publications Functions (show sections)
17	LY6E	Lymphocyte Antigen 6 Family Member E	Protein Coding	7.94	GeneCards inferred via : Functions (show sections)
18	CCR5AS	CCR5 Antisense RNA	RNA Gene	7.63	GeneCards inferred via : Variants (show sections)
19	IFNA1	Interferon Alpha 1	Protein Coding	7.44	GeneCards inferred via : Publications (show sections)
20	RTN3	Reticulon 3	Protein Coding	7.41	GeneCards inferred via : Proteins (show sections)

Sources

Variations for West Nile Virus

ClinVar genetic disease variations for West Nile Virus:

⁶ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	CCR5	NM_000579.3(CCR5):c.554_585del (p.Ser185fs)	deletion	Benign	8184	rs333	3:46414944-46414975	3:46373453-46373484

Sources

Expression for West Nile Virus

Search GEO for disease gene expression data for West Nile Virus.

Sources

Pathways for West Nile Virus

Pathways related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 15)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.39	RSAD2 MKRN1 ITGB3 ITGAV IRF3 IFNA1
2	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.08	RSAD2 ITGB3 IRF3 IFNA1 IFITM3 IFITM2
3	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.7	ITGB3 ITGAV IRF3 IFNA1 CCR5
4	Herpes simplex virus 1 infection ³⁶	12.52	ITGB3 IRF3 IFNA1 IFIH1 DDX58
5	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.41	RSAD2 IRF3 IFNA1 IFIH1 DDX58 CLEC4M
6	Cytosolic sensors of pathogen-associated DNA ⁶⁵ Show member pathways Cytosolic DNA-sensing pathway ³⁶ DEx/H-box helicases activate type I IFN and inflammatory cytokines production ⁶⁵ IkBA variant leads to EDA-ID ⁶⁵ IKBKB deficiency causes SCID ⁶⁵ IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) ⁶⁵ IRF3 mediated activation of type 1 IFN ⁶⁵ IRF3-mediated induction of type I IFN ⁶⁵ LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production ⁶⁵ Regulation by TREX1 ⁶⁵ Regulation of innate immune responses to cytosolic DNA ⁶⁵ RIP-mediated NFkB activation via ZBP1 ⁶⁵ STAT6-mediated induction of chemokines ⁶⁵ STING mediated induction of host immune responses ⁶⁵ TAK1 activates NFkB by phosphorylation and activation of IKKs complex ⁶⁵ TRAF6 mediated NF-kB activation ⁶⁵ ZBP1(DAI) mediated induction of type I IFNs ⁶⁵	12.33	IRF3 IFNA1 IFIH1 DDX58
7	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁵ Show member pathways Negative regulators of RIG-I/MDA5 signaling ⁶⁵ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁵ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁶ TRAF3-dependent IRF activation pathway ⁶⁵ TRAF6 mediated IRF7 activation ⁶⁵	12.29	IRF3 IFNA1 IFIH1 DDX58
8	NF-kappaB Signaling ⁴	12.28	RSAD2 IRF3 IFNA1 IFIH1 DDX58
9	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	11.94	RSAD2 IRF3 IFNA1 IFITM3 IFITM2 IFITM1
10	Phagosome ³⁶	11.89	ITGB3 ITGAV CLEC4M CD209
11	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	11.78	ITGB3 ITGAV CD209
12	Interferon gamma signaling ⁶⁵ Show member pathways Interferon Signaling ⁶⁵ Regulation of IFNG signaling ⁶⁵	11.66	RSAD2 IRF3 IFNA1 IFITM3 IFITM2 IFITM1
13	Signal transduction by L1 ⁶⁵	10.87	ITGB3 ITGAV
14	Osteoblast Signaling ¹	10.62	ITGB3 ITGAV
15	MFAP5-mediated ovarian cancer cell motility and invasiveness ¹	10.54	ITGB3 ITGAV

Sources

GO Terms for West Nile Virus

Cellular components related to West Nile Virus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:0005886	10.18	RTN3 LY6E ITGB3 ITGAV IFITM3 IFITM2
2	ruffle membrane	GO:0032587	9.5	ITGB3 ITGAV DDX58
3	lamellipodium membrane	GO:0031258	9.43	ITGB3 ITGAV
4	filopodium membrane	GO:0031527	9.37	ITGB3 ITGAV
5	alphav-beta3 integrin-IGF-1-IGF1R complex	GO:0035867	9.26	ITGB3 ITGAV
6	alphav-beta3 integrin-HMGB1 complex	GO:0035868	9.16	ITGB3 ITGAV
7	alphav-beta3 integrin-PKCalpha complex	GO:0035866	8.96	ITGB3 ITGAV
8	integrin alphav-beta3 complex	GO:0034683	8.62	ITGB3 ITGAV

Biological processes related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 38)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune system process	GO:0002376	10.02	RSAD2 IRF3 IFITM3 IFITM2 IFITM1 IFIH1
2	response to virus	GO:0009615	9.85	RSAD2 IFITM3 IFITM2 IFITM1 IFIH1 DDX58
3	innate immune response	GO:0045087	9.85	RSAD2 IRF3 IFITM3 IFITM2 IFITM1 IFIH1
4	viral entry into host cell	GO:0046718	9.83	ITGB3 ITGAV CLEC4M CD209
5	response to exogenous dsRNA	GO:0043330	9.77	IRF3 IFNA1 DDX58
6	negative regulation of type I interferon production	GO:0032480	9.76	IRF3 IFIH1 DDX58
7	positive regulation of interferon-beta production	GO:0032728	9.75	IRF3 IFIH1 DDX58
8	type I interferon signaling pathway	GO:0060337	9.73	RSAD2 IRF3 IFNA1 IFITM3 IFITM2 IFITM1
9	response to interferon-gamma	GO:0034341	9.71	IFITM3 IFITM2 IFITM1
10	negative regulation of viral genome replication	GO:0045071	9.71	RSAD2 IFITM3 IFITM2 IFITM1
11	cellular response to exogenous dsRNA	GO:0071360	9.69	IRF3 IFIH1 DDX58
12	apoptotic cell clearance	GO:0043277	9.68	ITGB3 ITGAV
13	cell adhesion mediated by integrin	GO:0033627	9.67	ITGB3 ITGAV
14	cell-substrate adhesion	GO:0031589	9.67	ITGB3 ITGAV
15	viral genome replication	GO:0019079	9.67	CLEC4M CD209
16	negative regulation of viral entry into host cell	GO:0046597	9.67	IFITM3 IFITM2 IFITM1
17	negative regulation of macrophage derived foam cell differentiation	GO:0010745	9.66	ITGB3 ITGAV
18	positive regulation of interferon-alpha secretion	GO:1902741	9.66	IFIH1 DDX58
19	negative regulation of lipid storage	GO:0010888	9.65	ITGB3 ITGAV
20	positive regulation of response to cytokine stimulus	GO:0060760	9.65	IFIH1 DDX58
21	modulation by virus of host morphology or physiology	GO:0019048	9.65	CLEC4M CD209
22	positive regulation of interferon-alpha production	GO:0032727	9.65	IRF3 IFIH1 DDX58
23	apolipoprotein A-I-mediated signaling pathway	GO:0038027	9.64	ITGB3 ITGAV
24	cell-cell recognition	GO:0009988	9.64	CLEC4M CD209
25	detection of virus	GO:0009597	9.63	IFIH1 DDX58
26	positive regulation of interferon-beta secretion	GO:0035549	9.63	IFIH1 DDX58
27	response to interferon-beta	GO:0035456	9.63	IFITM3 IFITM2 IFITM1
28	virion attachment to host cell	GO:0019062	9.62	CLEC4M CD209
29	negative regulation of lipid transport	GO:0032369	9.62	ITGB3 ITGAV
30	peptide antigen transport	GO:0046968	9.61	CLEC4M CD209
31	negative regulation of low-density lipoprotein particle receptor biosynthetic process	GO:0045715	9.61	ITGB3 ITGAV
32	response to interferon-alpha	GO:0035455	9.61	IFITM3 IFITM2 IFITM1
33	defense response to virus	GO:0051607	9.61	RSAD2 IRF3 IFNA1 IFITM3 IFITM2 IFITM1
34	MDA-5 signaling pathway	GO:0039530	9.6	IRF3 IFIH1
35	negative regulation of lipoprotein metabolic process	GO:0050748	9.57	ITGB3 ITGAV
36	cytoplasmic pattern recognition receptor signaling pathway in response to virus	GO:0039528	9.56	IFIH1 DDX58
37	regulation of type III interferon production	GO:0034344	9.55	IFIH1 DDX58
38	viral process	GO:0016032	9.4	RTN3 RSAD2 ITGB3 ITGAV IRF3 IFIH1

Molecular functions related to West Nile Virus according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mannose binding	GO:0005537	9.4	CLEC4M CD209
2	virion binding	GO:0046790	9.37	CLEC4M CD209
3	insulin-like growth factor I binding	GO:0031994	9.32	ITGB3 ITGAV
4	neuregulin binding	GO:0038132	9.26	ITGB3 ITGAV
5	C-X3-C chemokine binding	GO:0019960	9.16	ITGB3 ITGAV
6	coreceptor activity	GO:0015026	9.13	ITGB3 ITGAV CCR5
7	virus receptor activity	GO:0001618	9.02	ITGB3 ITGAV CLEC4M CD209 CCR5

Sources

Sources for West Nile Virus

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

West Nile Virus (WNV)

Aliases & Classifications for West Nile Virus

MalaCards integrated aliases for West Nile Virus:

Characteristics:

Orphanet epidemiological data:

Classifications:

External Ids:

Summaries for West Nile Virus

Related Diseases for West Nile Virus

Diseases related to West Nile Virus via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to West Nile Virus:

Symptoms & Phenotypes for West Nile Virus

Clinical features from OMIM:

UMLS symptoms related to West Nile Virus:

GenomeRNAi Phenotypes related to West Nile Virus according to GeneCards Suite gene sharing:

Drugs & Therapeutics for West Nile Virus

Drugs for West Nile Virus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Genetic Tests for West Nile Virus

Genetic tests related to West Nile Virus:

Anatomical Context for West Nile Virus

MalaCards organs/tissues related to West Nile Virus:

Publications for West Nile Virus

Articles related to West Nile Virus:

Genes for West Nile Virus

Genes related to West Nile Virus (1 elite genes):

Variations for West Nile Virus

ClinVar genetic disease variations for West Nile Virus:

Expression for West Nile Virus

Pathways for West Nile Virus

Pathways related to West Nile Virus according to GeneCards Suite gene sharing:

GO Terms for West Nile Virus

Cellular components related to West Nile Virus according to GeneCards Suite gene sharing:

Biological processes related to West Nile Virus according to GeneCards Suite gene sharing:

Molecular functions related to West Nile Virus according to GeneCards Suite gene sharing:

Sources for West Nile Virus

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :