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WNV
MCID: WST005
MIFTS: 55

West Nile Virus (WNV)

Categories: Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for West Nile Virus

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MalaCards integrated aliases for West Nile Virus:

Name: West Nile Virus 56 74 52 42
West Nile Virus, Susceptibility to 56 29 13 6 39
Encephalitis, West Nile Fever 71
West Nile Viral Infection 71
Wnv, Susceptibility to 56
West-Nile Encephalitis 58
West Nile Fever 71
West-Nile Fever 58
Wnv 56

Characteristics:

Orphanet epidemiological data:

58
west-nile encephalitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Infectious diseases
Anatomical: Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare neurological diseases
Rare infectious diseases


External Ids:

OMIM 56 610379
ICD10 via Orphanet 33 A92.3
UMLS via Orphanet 72 C0043124 C0751583
Orphanet 58 ORPHA83476
UMLS 71 C0043124 C0751583 C1096184
Sources

Summaries for West Nile Virus

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MedlinePlus : 42 West Nile virus (WNV) is an infectious disease that first appeared in the United States in 1999. Infected mosquitoes spread the virus that causes it. People who get WNV usually have no symptoms or mild symptoms. The symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. They can last a few days to several weeks, and usually go away on their own. If West Nile virus enters the brain, however, it can be life-threatening. It may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. A physical exam, medical history, and laboratory tests can diagnose it. Older people and those with weakened immune systems are most at risk. There are no specific vaccines or treatments for human WNV disease. The best way to avoid WNV is to prevent mosquito bites: Use insect repellent Get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels Stay indoors between dusk and dawn, when mosquitoes are most active Use screens on windows to keep mosquitoes out

MalaCards based summary : West Nile Virus, also known as west nile virus, susceptibility to, is related to west nile fever and west nile encephalitis, and has symptoms including seizures, tremor and fever. An important gene associated with West Nile Virus is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Maraviroc and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related phenotypes are Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection and immune system

OMIM : 56 WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle between avian hosts and mosquito vectors. The virus was first isolated from a Ugandan woman in 1937 and subsequently emerged in Europe and, in 1999, in New York, with eventual spread throughout North America. WNV causes a spectrum of disease ranging from acute fever to lethal encephalitis. Susceptibility to WNV is increased in the elderly and in immunocompromised individuals (summary by Diamond and Klein (2006) and Glass et al. (2005)). (610379)

Wikipedia : 74 West Nile virus (WNV) is a single-stranded RNA virus that causes West Nile fever. It is a member of the... more...

Sources

Related Diseases for West Nile Virus

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Diseases related to West Nile Virus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 294)
# Related Disease Score Top Affiliating Genes
1 west nile fever 33.0 OAS1 CLEC4M CD209 CCR5
2 west nile encephalitis 33.0 OAS1 CLEC4M CCR5
3 japanese encephalitis 30.8 TLR3 SPCS1 RSAD2 CLEC4M CD209
4 rift valley fever 30.5 IFITM3 IFITM2 IFITM1 CD209
5 avian influenza 30.5 IFNA1 DDX58 CCR5
6 encephalitis 30.4 TLR3 SPCS1 RSAD2 IRF3 DDX58 CLEC4M
7 yellow fever 30.4 SPCS1 RSAD2 OAS1 CCR5
8 chikungunya 30.2 RSAD2 OAS1 DDX58 CD209
9 rabies 29.8 TLR3 IRF3 IFNA1 DDX58
10 newcastle disease 29.8 TLR3 IRF3 IFNA1 DDX58
11 dengue virus 29.8 RSAD2 IFITM3 IFITM2 IFITM1 IFIH1 EXOC1
12 severe acute respiratory syndrome 29.7 IRF3 IFNA1 DDX58 CLEC4M CD209 CCR5
13 immune deficiency disease 29.7 IFNA1 CLEC4M CD209 CCR5
14 stomatitis 29.6 RSAD2 IFNA1 IFITM3 IFITM2 DDX58
15 tick-borne encephalitis 29.5 TLR3 RSAD2 OAS1 DDX58 CD209 CCR5
16 thrombocytopenia 29.0 ITGB3 IFNA1 IFIH1 CFH CD209
17 hepatitis c virus 28.7 SPCS1 RSAD2 IRF3 IFITM1 IFIH1 DDX58
18 hepatitis c 28.7 TLR3 RSAD2 IRF3 IFNA1 DDX58 CLEC4M
19 human immunodeficiency virus type 1 28.5 TLR3 IRF3 IFNA1 CLEC4M CD209 CCR5AS
20 measles 28.3 TLR3 OAS1 IRF3 IFNA1 IFIH1 DDX58
21 viral infectious disease 28.2 TLR3 OAS1 IRF3 IFNA1 IFIH1 DDX58
22 mouth disease 27.9 TLR3 OAS1 ITGAV IRF3 IFNA1 IFIH1
23 influenza 27.6 TLR3 RSAD2 IRF3 IFNA1 IFITM3 IFITM2
24 herpes simplex 27.4 TLR3 OAS1 ITGAV IRF3 IFNA1 IFIH1
25 systemic lupus erythematosus 27.4 TLR3 OAS1 IRF3 IFNA1 IFIH1 DDX58
26 kunjin encephalitis 11.6
27 acute flaccid myelitis 11.6
28 meningoencephalitis 11.0
29 st. louis encephalitis 10.9
30 viral encephalitis 10.9
31 poliomyelitis 10.8
32 exanthem 10.7
33 triiodothyronine receptor auxiliary protein 10.7
34 meningitis 10.7
35 tremor 10.7
36 ataxia and polyneuropathy, adult-onset 10.7
37 myocarditis 10.6
38 chorioretinitis 10.6
39 meningitis and encephalitis 10.6
40 aseptic meningitis 10.6
41 myelitis 10.6
42 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.6
43 eastern equine encephalitis 10.6
44 pica disease 10.6
45 murray valley encephalitis 10.5
46 guillain-barre syndrome 10.5
47 vasculitis 10.5
48 myoclonus 10.5
49 neuritis 10.5
50 optic neuritis 10.5

Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to West Nile Virus
Sources

Symptoms & Phenotypes for West Nile Virus

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Clinical features from OMIM:

610379

UMLS symptoms related to West Nile Virus:


seizures, tremor, fever, pruritus, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness

GenomeRNAi Phenotypes related to West Nile Virus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection GR00233-A-1 9.02 IFIH1 IFITM2 IFITM3 IRF3 SPCS1

MGI Mouse Phenotypes related to West Nile Virus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 CCR5 CFH CLEC4M DDX58 IFIH1 IFITM3
Sources

Drugs & Therapeutics for West Nile Virus

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Drugs for West Nile Virus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Maraviroc Approved, Investigational Phase 4 376348-65-1 3002977
2 Vaccines Phase 4
3 Immunologic Factors Phase 4
4 Antiviral Agents Phase 4
5 Anti-Infective Agents Phase 4
6 Anti-Retroviral Agents Phase 4
7 Anti-HIV Agents Phase 4
8
Ribavirin Approved Phase 2 36791-04-5 37542
9
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
10
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
11 Antimetabolites Phase 2
12 Pharmaceutical Solutions Phase 2
13 Immunoglobulin G Phase 2
14 Rho(D) Immune Globulin Phase 2
15 Immunoglobulins, Intravenous Phase 2
16 gamma-Globulins Phase 2
17 Antibodies, Monoclonal Phase 2
18 Immunoglobulins Phase 2
19 Antibodies Phase 2
20
Aluminum sulfate Approved Phase 1 10043-01-3
21
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
22 Gastrointestinal Agents Phase 1
23 Adjuvants, Immunologic Phase 1
24 Anti-Ulcer Agents Phase 1
25 Antacids Phase 1

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Randomised, Placebo Controlled, Phase IV, Safety and Exploratory Immunogenicity Study on Maraviroc, an Oral ART CCR5 Inhibitor, on the Intensification of Immune Function in HIV-1 Infected Subjects Receiving Immunisation With Novel Antigens Terminated NCT01049204 Phase 4 Maraviroc;placebo
2 Treatment of Japanese Encephalitis - a Double Blind Placebo Controlled Trial Unknown status NCT00216268 Phase 2 Ribavirin
3 Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults. Completed NCT00746798 Phase 2
4 Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
5 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (Omr-IgG-am) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus(WNV) Completed NCT00069316 Phase 2 Omr-IgG-am
6 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (OMR-IGG-AM) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus (WNV) Encephalitis and/or Myelitis Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
7 A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRelâ„¢ (batch 20081217)]
8 Most Closely HLA Matched Allogeneic Virus Specific Cytotoxic T-Lymphocytes (CTL) to Treat Persistent Reactivation Or Infection With Adenovirus, CMV and EBV After Hemopoietic Stem Cell Transplantation (HSCT) Completed NCT00711035 Phase 1, Phase 2
9 Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus Terminated NCT00927953 Phase 2
10 Phase II Trial of ID-Specific Donor Vaccinated Lymphocyte Infusion for Patients With Myeloma Relapsing or Failing to Achieve a Complete Remission After an Allogenic Transplant Terminated NCT01174082 Phase 2 GM-CSF
11 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00537147 Phase 1
12 Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00094718 Phase 1
13 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
14 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
15 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3´Î”30 Chimeric Virus Vaccine (WN/DEN4Δ30), a Live Attenuated Vaccine for West Nile Encephalitis, in Flavivirus-naïve Adults 50-65 Years of Age Completed NCT02186626 Phase 1
16 A Double Blind, Randomized, Placebo-Controlled, Phase I Dose Escalation Trial to Evaluate the Safety and Immunogenicity of an Inactivated West Nile Virus Vaccine, HydroVax-001, in Healthy Adults Completed NCT02337868 Phase 1
17 Phase 1, Open-Label, Safety Study of HBV-002 (West Nile Recombinant Subunit Vaccine) in Healthy Adults Completed NCT00707642 Phase 1
18 Pharmacokinetic Study of AVI-4020 in Cerebral Spinal Fluid Among Healthy Adult Males Following Intravenous Administration Completed NCT00387283 Phase 1 AVI-4020 Injection
19 A Phase 1, Randomized, Double-Blind, Dose-Escalation Cohort Study to Evaluate the Safety, Tolerability and Pharmacokinetics of a Single Intravenous Infusion of MGAWN1, a Neutralizing, Humanized, Monoclonal Antibody (IgG1k) to West Nile Virus, in Healthy Adults Completed NCT00515385 Phase 1 MGAWN1;MGAWN1
20 Pharmacokinetic Study of AVI-4065 in Cerebral Spinal Fluid Among Healthy Adult Males Following Subcutaneous Administration Completed NCT00381433 Phase 1 AVI-4065 Injection
21 Randomized, Double-Blind, Placebo-Controlled, Phase 1 Study in Healthy Volunteers to Evaluate the Safety and Immunogenicity of AGS-v, a Universal Mosquito-Borne Disease Vaccine Completed NCT03055000 Phase 1
22 An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
23 Assessment of the Impact of Notification of Blood Donors Testing Positive for Microbiology Markers: What is the Psychological Impact of Notification and Does the Method of Notification Influence the Outcome? Unknown status NCT01050881
24 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
25 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00138463
26 Surveillance of Summer Febrile Syndromes of Viral Origin in South of France Completed NCT00842166
27 VRC 300: Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases Completed NCT00068926
28 Retrovirus Epidemiology Donor Study-II (REDS-II) Completed NCT00097006
29 Pilot Study to Detect DENGUE Virus in Sperm. Completed NCT03612609
30 Organ Transplant Infection Prevention and Detection Project 1.0; Cohort Study of Transplant Recipients at "Ultra-High" Risk for Invasive Fungal Infections Completed NCT00177801
31 Clinical Evaluation of the FilmArray® Global Fever (GF) Panel Recruiting NCT02968355
32 Descriptive and Prognostic Study of Arbovirus Infections in France, Based on a Hospital Cohort of Children and Adults With Suspected Arbovirose.r Recruiting NCT01099852
33 Autologous Ovarian Tissue Transplantation Recruiting NCT03496636
34 The Collection and Storage of Umbilical Cord Blood for Transplantation Recruiting NCT01728545
35 The Threat of Infectious Encephalitis in Southeast Asia: SouthEast Asia Encephalitis Project Active, not recruiting NCT04089436
36 Cell Harvest and Preparation for Surgery Branch Adoptive Cell Therapy Protocols Enrolling by invitation NCT00068003
37 Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus No longer available NCT01206504

Search NIH Clinical Center for West Nile Virus

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ribavirin
Sources

Genetic Tests for West Nile Virus

About this section

Genetic tests related to West Nile Virus:

# Genetic test Affiliating Genes
1 West Nile Virus, Susceptibility to 29 CCR5
Sources

Anatomical Context for West Nile Virus

About this section

MalaCards organs/tissues related to West Nile Virus:

40
Testes, Brain, T Cells, Spinal Cord, B Cells, Skin, Kidney
Sources

Publications for West Nile Virus

About this section

Articles related to West Nile Virus:

(show top 50) (show all 6228)
# Title Authors PMID Year
1
CCR5 deficiency increases risk of symptomatic West Nile virus infection. 61 56 6
16418398 2006
2
A complement-microglial axis drives synapse loss during virus-induced memory impairment. 61 56
27337340 2016
3
Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis. 61 56
21131425 2011
4
Host genetic risk factors for West Nile virus infection and disease progression. 61 56
21935451 2011
5
Tregs control the development of symptomatic West Nile virus infection in humans and mice. 61 56
19855131 2009
6
Key role of T cell defects in age-related vulnerability to West Nile virus. 61 56
19901080 2009
7
Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. 61 56
19247438 2009
8
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. 61 56
19200759 2009
9
Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. 61 56
17909632 2007
10
A genetic basis for human susceptibility to West Nile virus. 61 56
16750369 2006
11
Protective immune responses against West Nile virus are primed by distinct complement activation pathways. 61 56
16651386 2006
12
Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. 61 56
16230476 2005
13
Cochlear-Vestibular Impairment due to West Nile Virus Infection. 61 42
31366220 2019
14
West Nile Virus and Other Domestic Nationally Notifiable Arboviral Diseases - United States, 2018. 61 42
31393865 2019
15
Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. 6
19017985 2008
16
The geographic spread of the CCR5 Delta32 HIV-resistance allele. 6
16216086 2005
17
The case for selection at CCR5-Delta32. 6
16248677 2005
18
The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. 6
15863470 2005
19
Reappraisal of the historical selective pressures for the CCR5-Delta32 mutation. 6
15744032 2005
20
A mutated CCR5 gene may have favorable prognostic implications in MS. 6
12874407 2003
21
Absence of the HIV-1 protective Delta ccr5 allele in most ethnic populations of India. 6
11781692 2001
22
The coreceptor mutation CCR5Delta32 influences the dynamics of HIV epidemics and is selected for by HIV. 6
11517319 2001
23
Chemokine receptor polymorphism in transplantation immunology: no longer just important in AIDS. 6
11403804 2001
24
CC chemokine receptor 5 and renal-transplant survival. 6
11403814 2001
25
Delta 32 deletion of CCR5 gene and association with asthma or atopy. 6
11081537 2000
26
CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group. 6
10803840 2000
27
Prevalence of CCR5delta32 in allergic diseases. 6
10615909 2000
28
Association of CCR5 delta32 with reduced risk of asthma. 6
10520641 1999
29
Distribution of the CCR5 gene 32-bp deletion in Europe. 6
9768627 1998
30
Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. 6
9585595 1998
31
Mutational analysis of the CCR5 and CXCR4 genes (HIV-1 co-receptors) in resistance to HIV-1 infection and AIDS development among intravenous drug users. 6
9600249 1998
32
The deltaccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe. 6
9466996 1998
33
First report of a healthy Indian heterozygous for delta 32 mutant of HIV-1 co-receptor-CCR5 gene. 6
9511755 1998
34
The extent of genetic variation in the CCR5 gene. 6
9207783 1997
35
Global distribution of the CCR5 gene 32-basepair deletion. 6
9140404 1997
36
HIV-1 infection in an individual homozygous for the CCR5 deletion allele. 6
9055842 1997
37
Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. 6
9132277 1997
38
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. 6
8756719 1996
39
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. 6
8751444 1996
40
A Disturbing Decline. 42
31167056 2019
41
Vector derived artificial miRNA mediated inhibition of West Nile virus replication and protein expression. 61
31884102 2020
42
Locally temperature - driven mathematical model of West Nile virus spread in Germany. 61
31866397 2020
43
Genetic diversity and population structure of Culex modestus across Europe: does recent appearance in the United Kingdom reveal a tendency for geographical spread? 61
31603254 2020
44
Can local risk of West Nile virus infection be predicted from previous cases? A descriptive study in Quebec, 2011-2016. 61
32020540 2020
45
The knowns and unknowns of West Nile virus in Europe: what did we learn from the 2018 outbreak? 61
31914833 2020
46
BAFF Produced by Neutrophils and Dendritic Cells Is Regulated Differently and Has Distinct Roles in Antibody Responses and Protective Immunity against West Nile Virus. 61
32034064 2020
47
Probable transfusion transmission of West Nile virus from an apheresis platelet that screened non-reactive by individual donor-nucleic acid testing. 61
31633814 2020
48
Detection of enzootic circulation of a new strain of West Nile virus lineage 1 in sentinel chickens in the north of Tunisia. 61
31647898 2020
49
Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection. 61
31810760 2020
50
Recent rapid changes in the spatio-temporal distribution of West Nile Neuro-invasive Disease in Italy. 61
31612606 2020
Sources

Variations for West Nile Virus

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ClinVar genetic disease variations for West Nile Virus:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CCR5 NM_000579.3(CCR5):c.554_585del (p.Ser185fs)deletion Benign 8184 rs333 3:46414944-46414975 3:46373453-46373484
Sources

Expression for West Nile Virus

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Search GEO for disease gene expression data for West Nile Virus.
Sources

Pathways for West Nile Virus

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Pathways related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.65 TLR3 RSAD2 OAS1 MKRN1 ITGB3 ITGAV
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.18 RSAD2 OAS1 ITGB3 IRF3 IFNA1 IFITM3
3
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 12.94 TLR3 RSAD2 OAS1 IRF3 IFNA1 IFIH1
4
Human cytomegalovirus infection 36
Show member pathways
 12.77 TLR3 ITGB3 ITGAV IRF3 IFNA1 CCR5
5
Herpes simplex virus 1 infection 36
12.64 TLR3 OAS1 ITGB3 IRF3 IFNA1 IFIH1
6
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 65
Show member pathways
 12.57 TLR3 IRF3 IFNA1 IFIH1 DDX58
7
NF-kappaB Signaling 4
12.32 TLR3 RSAD2 OAS1 IRF3 IFNA1 IFIH1
8
Measles 36
Show member pathways
 12.32 TLR3 RSAD2 OAS1 IRF3 IFNA1 IFIH1
9
Cytosolic sensors of pathogen-associated DNA 65
Show member pathways
 12.26 TLR3 IRF3 IFIH1 DDX58
10
VEGF Pathway (Qiagen) 63
Show member pathways
 12.24 TLR3 ITGB3 ITGAV IRF3
11
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.08 RSAD2 OAS1 IRF3 IFNA1 IFITM3 IFITM2
12
Phagosome 36
11.96 ITGB3 ITGAV CLEC4M CD209
13
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.82 ITGB3 ITGAV CD209
14
Interferon gamma signaling 65
Show member pathways
 11.72 RSAD2 OAS1 IRF3 IFNA1 IFITM3 IFITM2
15
Phagocytosis of Microbes 63
11.63 TLR3 ITGB3 ITGAV
16
Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics 60
Show member pathways
 10.97 OAS1 IRF3 DDX58
17
Signal transduction by L1 65
10.91 ITGB3 ITGAV
18
Osteoblast Signaling 1
10.7 ITGB3 ITGAV
19
MFAP5-mediated ovarian cancer cell motility and invasiveness 1
10.62 ITGB3 ITGAV
Sources

GO Terms for West Nile Virus

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Cellular components related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 TLR3 ITGB3 ITGAV CD209 CCR5
2 ruffle membrane GO:0032587 9.5 ITGB3 ITGAV DDX58
3 filopodium membrane GO:0031527 9.37 ITGB3 ITGAV
4 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 9.26 ITGB3 ITGAV
5 alphav-beta3 integrin-HMGB1 complex GO:0035868 9.16 ITGB3 ITGAV
6 alphav-beta3 integrin-PKCalpha complex GO:0035866 8.96 ITGB3 ITGAV
7 integrin alphav-beta3 complex GO:0034683 8.62 ITGB3 ITGAV

Biological processes related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.06 TLR3 RSAD2 OAS1 IRF3 IFITM1 IFIH1
2 viral process GO:0016032 10 RSAD2 ITGB3 ITGAV IRF3 IFIH1 EXOC1
3 type I interferon signaling pathway GO:0060337 9.87 RSAD2 OAS1 IRF3 IFNA1 IFITM3 IFITM2
4 viral entry into host cell GO:0046718 9.86 ITGB3 ITGAV CLEC4M CD209
5 response to exogenous dsRNA GO:0043330 9.8 TLR3 IRF3 IFNA1 DDX58
6 negative regulation of type I interferon production GO:0032480 9.77 IRF3 IFIH1 DDX58
7 negative regulation of viral genome replication GO:0045071 9.77 RSAD2 OAS1 IFITM3 IFITM2 IFITM1
8 positive regulation of interferon-beta production GO:0032728 9.76 TLR3 IRF3 IFIH1 DDX58
9 response to virus GO:0009615 9.76 TLR3 RSAD2 OAS1 IFITM3 IFITM2 IFITM1
10 response to interferon-gamma GO:0034341 9.74 IFITM3 IFITM2 IFITM1
11 cellular response to exogenous dsRNA GO:0071360 9.73 TLR3 IRF3 IFIH1 DDX58
12 innate immune response GO:0045087 9.73 TLR3 RSAD2 OAS1 IRF3 IFITM3 IFITM2
13 negative regulation of viral entry into host cell GO:0046597 9.72 IFITM3 IFITM2 IFITM1
14 positive regulation of interferon-alpha production GO:0032727 9.71 IRF3 IFIH1 DDX58
15 response to interferon-beta GO:0035456 9.7 IFITM3 IFITM2 IFITM1
16 response to interferon-alpha GO:0035455 9.69 IFITM3 IFITM2 IFITM1
17 positive regulation of tumor necrosis factor secretion GO:1904469 9.67 IFIH1 DDX58
18 cell-substrate adhesion GO:0031589 9.67 ITGB3 ITGAV
19 viral genome replication GO:0019079 9.67 CLEC4M CD209
20 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.66 ITGB3 ITGAV
21 positive regulation of interferon-alpha secretion GO:1902741 9.66 IFIH1 DDX58
22 negative regulation of lipid storage GO:0010888 9.65 ITGB3 ITGAV
23 positive regulation of response to cytokine stimulus GO:0060760 9.65 IFIH1 DDX58
24 modulation by virus of host morphology or physiology GO:0019048 9.65 CLEC4M CD209
25 detection of virus GO:0009597 9.65 TLR3 IFIH1 DDX58
26 apolipoprotein A-I-mediated signaling pathway GO:0038027 9.64 ITGB3 ITGAV
27 cell-cell recognition GO:0009988 9.64 CLEC4M CD209
28 positive regulation of interferon-beta secretion GO:0035549 9.63 IFIH1 DDX58
29 virion attachment to host cell GO:0019062 9.63 CLEC4M CD209
30 negative regulation of lipid transport GO:0032369 9.62 ITGB3 ITGAV
31 peptide antigen transport GO:0046968 9.62 CLEC4M CD209
32 negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715 9.61 ITGB3 ITGAV
33 MDA-5 signaling pathway GO:0039530 9.61 IRF3 IFIH1
34 cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 9.6 IFIH1 DDX58
35 negative regulation of lipoprotein metabolic process GO:0050748 9.58 ITGB3 ITGAV
36 regulation of type III interferon production GO:0034344 9.58 IFIH1 DDX58
37 defense response to virus GO:0051607 9.36 TLR3 RSAD2 OAS1 IRF3 IFNA1 IFITM3

Molecular functions related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mannose binding GO:0005537 9.43 CLEC4M CD209
2 insulin-like growth factor I binding GO:0031994 9.4 ITGB3 ITGAV
3 virion binding GO:0046790 9.37 CLEC4M CD209
4 coreceptor activity GO:0015026 9.33 ITGB3 ITGAV CCR5
5 neuregulin binding GO:0038132 9.32 ITGB3 ITGAV
6 C-X3-C chemokine binding GO:0019960 9.26 ITGB3 ITGAV
7 double-stranded RNA binding GO:0003725 9.26 TLR3 OAS1 IFIH1 DDX58
8 virus receptor activity GO:0001618 9.02 ITGB3 ITGAV CLEC4M CD209 CCR5
Sources

Sources for West Nile Virus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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