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WNV
MCID: WST005
MIFTS: 55

West Nile Virus (WNV)

Categories: Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for West Nile Virus

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MalaCards integrated aliases for West Nile Virus:

Name: West Nile Virus 57 73 42
West Nile Virus, Susceptibility to 57 29 13 6
West-Nile Encephalitis 58 29
Virus, West Nile, Susceptibility to 39
Encephalitis, West Nile Fever 70
West Nile Viral Infection 70
Wnv, Susceptibility to 57
West Nile Fever 70
West-Nile Fever 58
Wnv 57

Characteristics:

Orphanet epidemiological data:

58
west-nile encephalitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:

MalaCards categories:
Global: Genetic diseases Infectious diseases Rare diseases
Anatomical: Neuronal diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare neurological diseases
Rare infectious diseases


External Ids:

OMIM® 57 610379
ICD10 via Orphanet 33 A92.3
UMLS via Orphanet 71 C0043124 C0751583
Orphanet 58 ORPHA83476
UMLS 70 C0043124 C0751583 C1096184
Sources

Summaries for West Nile Virus

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MedlinePlus : 42 West Nile virus (WNV) is an infectious disease that first appeared in the United States in 1999. Infected mosquitoes spread the virus that causes it. People who get WNV usually have no symptoms or mild symptoms. The symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. They can last a few days to several weeks, and usually go away on their own. If West Nile virus enters the brain, however, it can be life-threatening. It may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. A physical exam, medical history, and laboratory tests can diagnose it. Older people and those with weakened immune systems are most at risk. There are no specific vaccines or treatments for human WNV disease. The best way to avoid WNV is to prevent mosquito bites: Use insect repellent Get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels Stay indoors between dusk and dawn, when mosquitoes are most active Use screens on windows to keep mosquitoes out

MalaCards based summary : West Nile Virus, also known as west nile virus, susceptibility to, is related to west nile virus infection and west nile encephalitis, and has symptoms including seizures, tremor and fever. An important gene associated with West Nile Virus is CCR5 (C-C Motif Chemokine Receptor 5), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Glycine and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related phenotypes are Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection and hematopoietic system

OMIM® : 57 WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle between avian hosts and mosquito vectors. The virus was first isolated from a Ugandan woman in 1937 and subsequently emerged in Europe and, in 1999, in New York, with eventual spread throughout North America. WNV causes a spectrum of disease ranging from acute fever to lethal encephalitis. Susceptibility to WNV is increased in the elderly and in immunocompromised individuals (summary by Diamond and Klein (2006) and Glass et al. (2005)). (610379) (Updated 05-Apr-2021)

Wikipedia : 73 West Nile virus (WNV) is a single-stranded RNA virus that causes West Nile fever. It is a member of the... more...

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Related Diseases for West Nile Virus

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Diseases related to West Nile Virus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 311)
# Related Disease Score Top Affiliating Genes
1 west nile virus infection 33.4 IRF3 CCR5
2 west nile encephalitis 32.6 CLEC4M CCR5
3 west nile fever 32.0 IRF3 IFNA1 CLEC4M CD209 CCR5
4 encephalitis 31.2 SPCS1 RSAD2 IRF3 DDX58 CLEC4M CD209
5 chikungunya 31.0 RSAD2 DDX58 CD209
6 yellow fever 30.9 SPCS1 RSAD2 IL17A DDX58 CCR5
7 rift valley fever 30.9 IFITM3 IFITM2 IFITM1 CD209
8 eastern equine encephalitis 30.8 IFNA1 CLEC4M CD209
9 disease by infectious agent 30.8 IL17A IFNA1 CLEC4M CD209 CCR5
10 poliomyelitis 30.8 IFNA1 IFIH1 DDX58
11 zika fever 30.6 DDX58 CD209
12 avian influenza 30.4 IFNA1 DDX58 CCR5
13 tick-borne encephalitis 30.4 RSAD2 IFNA1 DDX58 CD209 CCR5
14 japanese encephalitis 30.3 SPCS1 RSAD2 IRF3 IFNA1 DDX58 CLEC4M
15 syphilis 30.3 IL17A CD209 CCR5
16 rabies 30.2 IRF3 IFNA1 DDX58
17 newcastle disease 30.2 IRF3 IFNA1 DDX58
18 lymphocytic choriomeningitis 30.2 IRF3 DDX58 CD209
19 human immunodeficiency virus type 1 30.2 IRF3 CLEC4M CD209 CCR5AS CCR5
20 viral infectious disease 29.9 IRF3 IFNA1 IFIH1 DDX58 CLEC4M CD209
21 parainfluenza virus type 3 29.9 IFNA1 DDX58
22 lyme disease 29.8 IL17A IFNA1 CFH
23 dengue shock syndrome 29.8 IFNA1 CLEC4M CD209
24 measles 29.8 IRF3 IFNA1 IFIH1 DDX58 CD209
25 dengue virus 29.8 SPCS1 RSAD2 IFITM3 IFITM2 IFITM1 IFIH1
26 immune deficiency disease 29.8 IRF3 IL17A IFNA1 CLEC4M CD209 CCR5
27 stomatitis 29.6 RSAD2 IFNA1 IFITM3 IFITM2 DDX58
28 severe acute respiratory syndrome 29.6 IRF3 IFNA1 IFIH1 DDX58 CLEC4M CD209
29 monkeypox 29.4 IRF3 IFNA1
30 hepatitis c 29.4 RSAD2 IRF3 IFNA1 DDX58 CLEC4M CCR5
31 herpes simplex 29.4 ITGAV IRF3 IFNA1 IFIH1 DDX58 CD209
32 mouth disease 29.2 ITGAV IRF3 IFNA1 IFIH1 DDX58 CD209
33 hemorrhagic disease 29.0 ITGB3 IRF3 IFNA1 IFIH1 DDX58 CFH
34 hepatitis 29.0 RSAD2 IRF3 IFNA1 IFIH1 DDX58 CLEC4M
35 thrombocytopenia 28.9 ITGB3 IL17A IFNA1 IFIH1 CFH CD209
36 hepatitis c virus 28.8 SPCS1 RSAD2 IRF3 IFITM1 IFIH1 DDX58
37 influenza 28.6 RSAD2 IRF3 IFNA1 IFITM3 IFITM2 IFITM1
38 west nile virus encephalitis 11.8
39 kunjin encephalitis 11.3
40 meningoencephalitis 11.1
41 st. louis encephalitis 10.9
42 viral encephalitis 10.9
43 exanthem 10.8
44 triiodothyronine receptor auxiliary protein 10.7
45 ataxia and polyneuropathy, adult-onset 10.7
46 tremor 10.7
47 chorioretinitis 10.7
48 aseptic meningitis 10.7
49 myocarditis 10.7
50 meningitis and encephalitis 10.7

Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to West Nile Virus
Sources

Symptoms & Phenotypes for West Nile Virus

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Clinical features from OMIM®:

610379 (Updated 05-Apr-2021)

UMLS symptoms related to West Nile Virus:


seizures; tremor; fever; back pain; headache; pruritus; syncope; pain; chronic pain; sciatica; vertigo/dizziness; sleeplessness

GenomeRNAi Phenotypes related to West Nile Virus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection GR00233-A-1 8.32 IFIH1

MGI Mouse Phenotypes related to West Nile Virus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.73 CCR5 CD209 CFH CLEC4M DDX58 IFIH1
2 immune system MP:0005387 9.4 CCR5 CFH CLEC4M DDX58 IFIH1 IFITM3
Sources

Drugs & Therapeutics for West Nile Virus

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Drugs for West Nile Virus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
2 Vaccines Phase 2
3 Pharmaceutical Solutions Phase 2
4 Immunologic Factors Phase 2
5 Immunoglobulins, Intravenous Phase 2
6 Immunoglobulin G Phase 2
7 gamma-Globulins Phase 2
8 Rho(D) Immune Globulin Phase 2
9 Immunoglobulins Phase 2
10 Antibodies, Monoclonal Phase 2
11 Antibodies Phase 2
12
Aluminum sulfate Approved Phase 1 10043-01-3
13
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Randomized, Double-blind, Placebo Controlled Phase II Trial of the Safety, Tolerability and Immunogenicity of Lyophilized ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
2 Randomized, Modified, Double-blind, Placebo-controlled, Phase II, Dose-ranging Study of the Safety and Immunogenicity of Single Dose ChimeriVax-WN02 Vaccine in Healthy Adults. Completed NCT00746798 Phase 2
3 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (Omr-IgG-am) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus(WNV) Completed NCT00069316 Phase 2 Omr-IgG-am
4 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (OMR-IGG-AM) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus (WNV) Encephalitis and/or Myelitis Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
5 Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus Terminated NCT00927953 Phase 2
6 Phase 1 Study of the Safety and Immunogenicity of West Nile/Dengue-4 3'delta30 Chimeric Virus Vaccine (WN/DEN4-3'delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00094718 Phase 1
7 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3'delta30 Chimeric Virus Vaccine (WN/DEN4delta30), a Live Attenuated Vaccine for West Nile Encephalitis Completed NCT00537147 Phase 1
8 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
9 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA017-00 VP, in Healthy Adult Volunteers Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
10 A Double Blind, Randomized, Placebo-Controlled, Phase I Dose Escalation Trial to Evaluate the Safety and Immunogenicity of an Inactivated West Nile Virus Vaccine, HydroVax-001, in Healthy Adults Completed NCT02337868 Phase 1
11 Phase 1 Study of the Safety and Immunogenicity of a 2-Dose Regimen of West Nile/Dengue 4-3´Î”30 Chimeric Virus Vaccine (WN/DEN4Δ30), a Live Attenuated Vaccine for West Nile Encephalitis, in Flavivirus-naïve Adults 50-65 Years of Age Completed NCT02186626 Phase 1
12 Pharmacokinetic Study of AVI-4020 in Cerebral Spinal Fluid Among Healthy Adult Males Following Intravenous Administration Completed NCT00387283 Phase 1 AVI-4020 Injection
13 Phase 1, Open-Label, Safety Study of HBV-002 (West Nile Recombinant Subunit Vaccine) in Healthy Adults Completed NCT00707642 Phase 1
14 A Phase 1, Randomized, Double-Blind, Dose-Escalation Cohort Study to Evaluate the Safety, Tolerability and Pharmacokinetics of a Single Intravenous Infusion of MGAWN1, a Neutralizing, Humanized, Monoclonal Antibody (IgG1k) to West Nile Virus, in Healthy Adults Completed NCT00515385 Phase 1 MGAWN1;MGAWN1
15 An Exploratory Study of the Safety, Tolerability, Pharmacokinetics and Potential Effectiveness of AVI-4020 Injection in Patients Presenting With Presumptive Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
16 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
17 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00138463
18 Validation of Laboratory Techniques, Strategies, and Types of Samples for Epidemiological Control in the Covid-19 Pandemic, Tarija-Bolivia Completed NCT04581083
19 Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus No longer available NCT01206504
20 Prospective Investigation of Oxidative Stress in West Nile Virus Infection Withdrawn NCT04371003

Search NIH Clinical Center for West Nile Virus

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Ribavirin
Sources

Genetic Tests for West Nile Virus

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Genetic tests related to West Nile Virus:

# Genetic test Affiliating Genes
1 West Nile Virus, Susceptibility to 29 CCR5
2 West-Nile Encephalitis 29
Sources

Anatomical Context for West Nile Virus

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MalaCards organs/tissues related to West Nile Virus:

40
Brain, Spinal Cord, T Cells, Kidney, Endothelial, B Cells, Skin
Sources

Publications for West Nile Virus

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Articles related to West Nile Virus:

(show top 50) (show all 6601)
# Title Authors PMID Year
1
CCR5 deficiency increases risk of symptomatic West Nile virus infection. 61 6 57
16418398 2006
2
A complement-microglial axis drives synapse loss during virus-induced memory impairment. 61 57
27337340 2016
3
Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis. 61 57
21131425 2011
4
Host genetic risk factors for West Nile virus infection and disease progression. 57 61
21935451 2011
5
Key role of T cell defects in age-related vulnerability to West Nile virus. 61 57
19901080 2009
6
Tregs control the development of symptomatic West Nile virus infection in humans and mice. 61 57
19855131 2009
7
Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. 57 61
19200759 2009
8
Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. 61 57
19247438 2009
9
Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. 61 57
17909632 2007
10
A genetic basis for human susceptibility to West Nile virus. 57 61
16750369 2006
11
Protective immune responses against West Nile virus are primed by distinct complement activation pathways. 61 57
16651386 2006
12
Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. 61 57
16230476 2005
13
Surveillance for West Nile Virus Disease - United States, 2009-2018. 61 42
33661868 2021
14
Notes from the Field: An Outbreak of West Nile Virus - Arizona, 2019. 61 42
33507888 2021
15
Potential Dual Role of West Nile Virus NS2B in Orchestrating NS3 Enzymatic Activity in Viral Replication. 42 61
33572517 2021
16
Interaction between RANTES promoter variant and CCR5Delta32 favors recovery from hepatitis B. 6
19017985 2008
17
Shared and distinct genetic variants in type 1 diabetes and celiac disease. 6
19073967 2008
18
The case for selection at CCR5-Delta32. 6
16248677 2005
19
The geographic spread of the CCR5 Delta32 HIV-resistance allele. 6
16216086 2005
20
The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source. 6
15863470 2005
21
Reappraisal of the historical selective pressures for the CCR5-Delta32 mutation. 6
15744032 2005
22
A mutated CCR5 gene may have favorable prognostic implications in MS. 6
12874407 2003
23
Absence of the HIV-1 protective Delta ccr5 allele in most ethnic populations of India. 6
11781692 2001
24
The coreceptor mutation CCR5Delta32 influences the dynamics of HIV epidemics and is selected for by HIV. 6
11517319 2001
25
CC chemokine receptor 5 and renal-transplant survival. 6
11403814 2001
26
Chemokine receptor polymorphism in transplantation immunology: no longer just important in AIDS. 6
11403804 2001
27
Delta 32 deletion of CCR5 gene and association with asthma or atopy. 6
11081537 2000
28
CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group. 6
10803840 2000
29
Prevalence of CCR5delta32 in allergic diseases. 6
10615909 2000
30
Association of CCR5 delta32 with reduced risk of asthma. 6
10520641 1999
31
Distribution of the CCR5 gene 32-bp deletion in Europe. 6
9768627 1998
32
Dating the origin of the CCR5-Delta32 AIDS-resistance allele by the coalescence of haplotypes. 6
9585595 1998
33
Mutational analysis of the CCR5 and CXCR4 genes (HIV-1 co-receptors) in resistance to HIV-1 infection and AIDS development among intravenous drug users. 6
9600249 1998
34
The deltaccr5 mutation conferring protection against HIV-1 in Caucasian populations has a single and recent origin in Northeastern Europe. 6
9466996 1998
35
First report of a healthy Indian heterozygous for delta 32 mutant of HIV-1 co-receptor-CCR5 gene. 6
9511755 1998
36
The extent of genetic variation in the CCR5 gene. 6
9207783 1997
37
Global distribution of the CCR5 gene 32-basepair deletion. 6
9140404 1997
38
HIV-1 infection in an individual homozygous for the CCR5 deletion allele. 6
9055842 1997
39
Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background, and quantified risk. 6
9132277 1997
40
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. 6
8756719 1996
41
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. 6
8751444 1996
42
Molecular cloning and functional expression of a new human CC-chemokine receptor gene. 6
8639485 1996
43
[West-Nile-Virus Infection acquired in Germany in a Kidney Transplant Recipient]. 61
33780997 2021
44
Mechanistic Modeling of SARS-CoV-2 and Other Infectious Diseases and the Effects of Therapeutics. 61
33410134 2021
45
Serologic evidence of West Nile virus and Saint Louis encephalitis virus in horses from Southern Brazil. 61
33797731 2021
46
Simultaneous circulation of two West Nile virus lineage 2 clades and Bagaza virus in the Zambezi region, Namibia. 61
33798192 2021
47
West Nile and Usutu virus infections in wild birds admitted to rehabilitation centres in Extremadura, western Spain, 2017-2019. 61
33677369 2021
48
Cerebrospinal Fluid Analysis for Viruses by Metagenomic Next-Generation Sequencing in Pediatric Encephalitis: Not Yet Ready for Prime Time? 61
33206020 2021
49
West Nile Virus Seroprevalence in an Outdoor Nonhuman Primate Breeding Colony in South Florida. 61
33441221 2021
50
Meteorological patterns and the evolution of West Nile virus in an environmentally stressed Mediterranean area. 61
33772423 2021
Sources

Variations for West Nile Virus

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ClinVar genetic disease variations for West Nile Virus:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CCR5 , CCR5AS NM_000579.3(CCR5):c.554_585del (p.Ser185fs) Deletion risk factor 8184 rs333 GRCh37: 3:46414944-46414975
GRCh38: 3:46373453-46373484
2 CCR5 , CCR5AS NM_000579.4(CCR5):c.187A>T (p.Ser63Cys) SNV Uncertain significance 992556 GRCh37: 3:46414580-46414580
GRCh38: 3:46373089-46373089
Sources

Expression for West Nile Virus

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Search GEO for disease gene expression data for West Nile Virus.
Sources

Pathways for West Nile Virus

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Pathways related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.42 RSAD2 MKRN1 ITGB3 ITGAV IRF3 IL17A
2
Cytokine Signaling in Immune system 65
Show member pathways
 13.07 RSAD2 ITGB3 IRF3 IL17A IFNA1 IFITM3
3
Human cytomegalovirus infection 36
Show member pathways
 12.71 ITGB3 ITGAV IRF3 IFNA1 CCR5
4
Measles 36
Show member pathways
 12.58 RSAD2 IRF3 IFNA1 IFIH1 DDX58 CLEC4M
5
Herpes simplex virus 1 infection 36
12.53 ITGB3 IRF3 IFNA1 IFIH1 DDX58
6
NF-kappaB Signaling 4
12.36 RSAD2 IRF3 IL17A IFNA1 IFIH1 DDX58
7
Cytosolic sensors of pathogen-associated DNA 65
Show member pathways
 12.33 IRF3 IFNA1 IFIH1 DDX58
8
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 65
Show member pathways
 12.29 IRF3 IFNA1 IFIH1 DDX58
9
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 11.91 RSAD2 IRF3 IL17A IFNA1 IFITM3 IFITM2
10
Phagosome 36
11.89 ITGB3 ITGAV CLEC4M CD209
11
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.78 ITGB3 ITGAV CD209
12
Interferon gamma signaling 65
Show member pathways
 11.66 RSAD2 IRF3 IFNA1 IFITM3 IFITM2 IFITM1
13
Osteoblast Signaling 1
10.62 ITGB3 ITGAV
14
MFAP5-mediated ovarian cancer cell motility and invasiveness 1
10.54 ITGB3 ITGAV
Sources

GO Terms for West Nile Virus

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Cellular components related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ruffle membrane GO:0032587 9.5 ITGB3 ITGAV DDX58
2 filopodium membrane GO:0031527 9.37 ITGB3 ITGAV
3 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 9.26 ITGB3 ITGAV
4 alphav-beta3 integrin-HMGB1 complex GO:0035868 9.16 ITGB3 ITGAV
5 alphav-beta3 integrin-PKCalpha complex GO:0035866 8.96 ITGB3 ITGAV
6 integrin alphav-beta3 complex GO:0034683 8.62 ITGB3 ITGAV

Biological processes related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10 RSAD2 IRF3 IL17A IFITM3 IFITM2 IFITM1
2 innate immune response GO:0045087 9.9 RSAD2 IRF3 IL17A IFITM3 IFITM2 IFITM1
3 response to virus GO:0009615 9.85 RSAD2 IFITM3 IFITM2 IFITM1 IFIH1 DDX58
4 positive regulation of interleukin-6 production GO:0032755 9.83 IL17A IFIH1 DDX58
5 positive regulation of tumor necrosis factor production GO:0032760 9.83 IL17A IFIH1 DDX58
6 viral entry into host cell GO:0046718 9.81 ITGB3 ITGAV CLEC4M CD209
7 type I interferon signaling pathway GO:0060337 9.8 RSAD2 IRF3 IFNA1 IFITM3 IFITM2 IFITM1
8 positive regulation of interferon-beta production GO:0032728 9.78 IRF3 IFIH1 DDX58
9 response to exogenous dsRNA GO:0043330 9.77 IRF3 IFNA1 DDX58
10 negative regulation of type I interferon production GO:0032480 9.75 IRF3 IFIH1 DDX58
11 negative regulation of viral genome replication GO:0045071 9.73 RSAD2 IFITM3 IFITM2 IFITM1
12 response to interferon-gamma GO:0034341 9.71 IFITM3 IFITM2 IFITM1
13 negative regulation of viral entry into host cell GO:0046597 9.71 LY6E IFITM3 IFITM2 IFITM1
14 positive regulation of interferon-alpha production GO:0032727 9.7 IRF3 IFIH1 DDX58
15 viral process GO:0016032 9.7 RSAD2 ITGB3 ITGAV IRF3 IFIH1 EXOC1
16 cell-substrate adhesion GO:0031589 9.67 ITGB3 ITGAV
17 viral genome replication GO:0019079 9.67 CLEC4M CD209
18 cellular response to exogenous dsRNA GO:0071360 9.67 IRF3 IFIH1 DDX58
19 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.66 ITGB3 ITGAV
20 negative regulation of low-density lipoprotein receptor activity GO:1905598 9.65 ITGB3 ITGAV
21 negative regulation of lipid storage GO:0010888 9.65 ITGB3 ITGAV
22 response to interferon-beta GO:0035456 9.65 IFITM3 IFITM2 IFITM1
23 modulation by virus of host morphology or physiology GO:0019048 9.64 CLEC4M CD209
24 positive regulation of response to cytokine stimulus GO:0060760 9.64 IFIH1 DDX58
25 apolipoprotein A-I-mediated signaling pathway GO:0038027 9.63 ITGB3 ITGAV
26 cell-cell recognition GO:0009988 9.63 CLEC4M CD209
27 response to interferon-alpha GO:0035455 9.63 IFITM3 IFITM2 IFITM1
28 detection of virus GO:0009597 9.62 IFIH1 DDX58
29 virion attachment to host cell GO:0019062 9.62 CLEC4M CD209
30 negative regulation of lipid transport GO:0032369 9.61 ITGB3 ITGAV
31 peptide antigen transport GO:0046968 9.59 CLEC4M CD209
32 MDA-5 signaling pathway GO:0039530 9.58 IRF3 IFIH1
33 negative regulation of lipoprotein metabolic process GO:0050748 9.57 ITGB3 ITGAV
34 cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 9.56 IFIH1 DDX58
35 regulation of type III interferon production GO:0034344 9.55 IFIH1 DDX58
36 defense response to virus GO:0051607 9.28 RSAD2 IRF3 IFNA1 IFITM3 IFITM2 IFITM1

Molecular functions related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virion binding GO:0046790 9.37 CLEC4M CD209
2 insulin-like growth factor I binding GO:0031994 9.32 ITGB3 ITGAV
3 neuregulin binding GO:0038132 9.26 ITGB3 ITGAV
4 C-X3-C chemokine binding GO:0019960 9.16 ITGB3 ITGAV
5 coreceptor activity GO:0015026 9.13 ITGB3 ITGAV CCR5
6 virus receptor activity GO:0001618 9.02 ITGB3 ITGAV CLEC4M CD209 CCR5
Sources

Sources for West Nile Virus

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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