MCID: WST005
MIFTS: 59

West Nile Virus

Categories: Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for West Nile Virus

MalaCards integrated aliases for West Nile Virus:

Name: West Nile Virus 58 77 54 44
West Nile Virus, Susceptibility to 58 30 13 6 41
Encephalitis, West Nile Fever 74
West Nile Viral Infection 74
Wnv, Susceptibility to 58
West-Nile Encephalitis 60
West Nile Fever 74
West-Nile Fever 60
Wnv 58

Characteristics:

Orphanet epidemiological data:

60
west-nile encephalitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

OMIM 58 610379
ICD10 via Orphanet 35 A92.3
UMLS via Orphanet 75 C0043124 C0751583
Orphanet 60 ORPHA83476

Summaries for West Nile Virus

MedlinePlus : 44 West Nile virus (WNV) is an infectious disease that first appeared in the United States in 1999. Infected mosquitoes spread the virus that causes it. People who get WNV usually have no symptoms or mild symptoms. The symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. They can last a few days to several weeks, and usually go away on their own. If West Nile virus enters the brain, however, it can be life-threatening. It may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. A physical exam, medical history, and laboratory tests can diagnose it. Older people and those with weakened immune systems are most at risk. There are no specific vaccines or treatments for human WNV disease. The best way to avoid WNV is to prevent mosquito bites: Use insect repellent Get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels Stay indoors between dusk and dawn, when mosquitoes are most active Use screens on windows to keep mosquitoes out NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : West Nile Virus, also known as west nile virus, susceptibility to, is related to japanese encephalitis and rift valley fever, and has symptoms including seizures, tremor and fever. An important gene associated with West Nile Virus is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Glycine and Immunoglobulins, Intravenous have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and t cells, and related phenotype is immune system.

OMIM : 58 WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle between avian hosts and mosquito vectors. The virus was first isolated from a Ugandan woman in 1937 and subsequently emerged in Europe and, in 1999, in New York, with eventual spread throughout North America. WNV causes a spectrum of disease ranging from acute fever to lethal encephalitis. Susceptibility to WNV is increased in the elderly and in immunocompromised individuals (summary by Diamond and Klein (2006) and Glass et al. (2005)). (610379)

Wikipedia : 77 West Nile virus (WNV) is a single-stranded RNA virus that causes West Nile fever. It is a member of the... more...

Related Diseases for West Nile Virus

Diseases related to West Nile Virus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 japanese encephalitis 30.6 CD209 CLEC4M DDX58 TLR3
2 rift valley fever 30.5 CD209 IFITM3
3 encephalitis 30.5 CCR5 CD209 CLEC4M DDX58 IRF3 RSAD2
4 severe acute respiratory syndrome 30.2 CD209 CLEC4M IFNA1 IRF3
5 noonan syndrome 3 30.2 DDX58 IFNA1 IRF3 RSAD2 TLR3
6 yellow fever 30.2 CCR5 OAS1 RSAD2
7 newcastle disease 30.0 DDX58 IFNA1 IRF3
8 tick-borne encephalitis 29.9 CCR5 CD209 OAS1 TLR3
9 dengue virus 29.9 CD209 DDX58 EXOC1 IFIH1 IFITM1 IFITM2
10 stomatitis 29.8 DDX58 IFITM2 IFITM3 RSAD2
11 hepatitis c 29.5 CLEC4M DDX58 IFNA1 IRF3 TLR3
12 hepatitis c virus 29.4 CCR5 CLEC4M DDX58 IFIH1 IFITM1 IRF3
13 measles 29.4 CD209 DDX58 IFIH1 IFNA1 TLR3
14 human immunodeficiency virus type 1 28.7 CCR5 CD209 CLEC4M IFNA1 IRF3 LOC102724297
15 herpes simplex 28.6 CD209 DDX58 IFIH1 IFNA1 IRF3 ITGAV
16 influenza 28.5 DDX58 IFIH1 IFITM1 IFITM2 IFITM3 IFNA1
17 viral infectious disease 28.3 CCR5 CD209 DDX58 IFIH1 IFNA1 IRF3
18 west nile fever 12.1
19 west nile encephalitis 12.0
20 kunjin encephalitis 11.4
21 acute flaccid myelitis 11.4
22 meningoencephalitis 10.7
23 st. louis encephalitis 10.6
24 meningitis 10.5
25 chorioretinitis 10.5
26 noonan syndrome 5 10.4
27 chikungunya 10.4
28 malaria 10.4
29 poliomyelitis 10.4
30 myoclonus 10.3
31 hepatitis 10.3
32 coccidioidomycosis 10.3
33 vasculitis 10.3
34 myasthenia gravis 10.2
35 retinal vasculitis 10.2
36 pica disease 10.2
37 myasthenia gravis congenital 10.2
38 opsoclonus-myoclonus syndrome 10.2
39 lymphopenia 10.2
40 aceruloplasminemia 10.2
41 ichthyosis prematurity syndrome 10.2
42 arthritis 10.2
43 hepatitis b 10.2
44 eastern equine encephalitis 10.2
45 murray valley encephalitis 10.2
46 optic neuritis 10.2
47 aseptic meningitis 10.2
48 quadriplegia 10.2
49 neuritis 10.2
50 myelitis 10.2

Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to West Nile Virus

Symptoms & Phenotypes for West Nile Virus

Clinical features from OMIM:

610379

UMLS symptoms related to West Nile Virus:


seizures, tremor, fever, pruritus, back pain, pain, headache, syncope, chronic pain, sciatica, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to West Nile Virus:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 CCR5 CFH CLEC4M DDX58 IFIH1 IFITM3

Drugs & Therapeutics for West Nile Virus

Drugs for West Nile Virus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
2 Immunoglobulins, Intravenous Phase 2,Phase 1
3 Antibodies Phase 2,Phase 1
4 Immunoglobulin G Phase 2,Phase 1
5 gamma-Globulins Phase 2,Phase 1
6 Rho(D) Immune Globulin Phase 2,Phase 1
7 Immunoglobulins Phase 2,Phase 1
8 Pharmaceutical Solutions Phase 1, Phase 2,Phase 2
9 Immunologic Factors Phase 1, Phase 2,Phase 2
10 Vaccines Phase 2,Phase 1
11 Antibodies, Monoclonal Phase 2,Phase 1
12
Aluminum sulfate Approved Phase 1 10043-01-3
13
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
14 Gastrointestinal Agents Phase 1
15 Antacids Phase 1
16 Adjuvants, Immunologic Phase 1
17 Anti-Ulcer Agents Phase 1

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus Disease Completed NCT00069316 Phase 2 Omr-IgG-am
2 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
3 Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults Completed NCT00746798 Phase 2
4 Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
5 Treatment of West Nile Virus With MGAWN1 Terminated NCT00927953 Phase 2
6 Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of Age Completed NCT02186626 Phase 1
7 Phase 1 Trial of Inactivated West Nile Virus Vaccine Completed NCT02337868 Phase 1
8 Phase I Study of West Nile Virus Vaccine Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
9 A Trial to Evaluate the Safety of a Single Intravenous Infusion of MGAWN1 in Healthy Adults Completed NCT00515385 Phase 1 MGAWN1;MGAWN1
10 Vaccine to Prevent West Nile Virus Disease Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
11 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
12 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Completed NCT00537147 Phase 1
13 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults Completed NCT00094718 Phase 1
14 Safety Study of HBV-002 West Nile Vaccine in Healthy Adults Completed NCT00707642 Phase 1
15 Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal Fluid Completed NCT00381433 Phase 1 AVI-4065 Injection
16 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
17 West Nile Virus Natural History Completed NCT00138463
18 Natural History of West Nile Virus Infection Completed NCT00069303
19 Surveillance of Summer Febrile Syndromes of Viral Origin in South of France Completed NCT00842166 Not Applicable
20 VRC 300: Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases Completed NCT00068926
21 Organ Transplant Infection Prevention and Detection Project Completed NCT00177801
22 Retrovirus Epidemiology Donor Study-II (REDS-II) Completed NCT00097006
23 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
24 Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure No longer available NCT01206504

Search NIH Clinical Center for West Nile Virus

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for West Nile Virus

Genetic tests related to West Nile Virus:

# Genetic test Affiliating Genes
1 West Nile Virus, Susceptibility to 30 CCR5

Anatomical Context for West Nile Virus

MalaCards organs/tissues related to West Nile Virus:

42
Brain, Testes, T Cells, Spinal Cord, Skin, Kidney, B Cells

Publications for West Nile Virus

Articles related to West Nile Virus:

(show top 50) (show all 3102)
# Title Authors Year
1
Fatal West Nile Virus Infection in a Virginia Opossum (Didelphis virginiana) with Pulmonary Lepidic-Predominant Adenocarcinoma. ( 31008678 )
2019
2
Serological Evidence of Tick-Borne Encephalitis and West Nile Virus Infections Among Children with Arthritis in Turkey. ( 30688547 )
2019
3
Simultaneous detection of Dengue virus, Chikungunya virus, Zika virus, Yellow fever virus and West Nile virus. ( 30930286 )
2019
4
Lazarus Effect of High Dose Corticosteroids in a Patient With West Nile Virus Encephalitis: A Coincidence or a Clue? ( 31106205 )
2019
5
Specific detection and differentiation of tick-borne encephalitis and West Nile virus induced IgG antibodies in humans and horses. ( 30985075 )
2019
6
Clinical and epidemiological features of West Nile virus equine encephalitis in New South Wales, Australia, 2011. ( 31025323 )
2019
7
A case of West Nile virus encephalitis accompanied by diabetic ketoacidosis and rhabdomyolysis. ( 30815360 )
2019
8
Sinus Bradycardia and QT Interval Prolongation in West Nile Virus Encephalitis: A Case Report. ( 30868034 )
2019
9
West Nile virus encephalitis in a young immunocompetent female in Omaha Nebraska. ( 30881858 )
2019
10
Vector Competence for West Nile Virus and St. Louis Encephalitis Virus (Flavivirus) of Three Tick Species of the Genus Amblyomma (Acari: Ixodidae). ( 30887949 )
2019
11
Microbiota variations in Culex nigripalpus disease vector mosquito of West Nile virus and Saint Louis Encephalitis from different geographic origins. ( 30643680 )
2019
12
West Nile virus encephalitis in GATA2 deficiency. ( 30697248 )
2019
13
West Nile virus associated with equid encephalitis in Brazil, 2018. ( 30318735 )
2019
14
Detection of West Nile Virus Infection in Viral Encephalitis Cases, China. ( 29985780 )
2019
15
Longitudinally extensive transverse myelitis in a patient infected with West Nile virus. ( 31005826 )
2019
16
Resource-Effective Serosurveillance for the Detection of West Nile Virus in Switzerland Using Abattoir Samples of Free-Range Laying Hens. ( 30457933 )
2019
17
West Nile virus in Algeria: a comprehensive overview. ( 30519477 )
2019
18
Reemergence of West Nile Virus Infections in Southern Greece, 2017. ( 30526732 )
2019
19
Forecasting the West-Nile virus in the USA: a Google Trends-based time series analysis. ( 30601755 )
2019
20
Influence of Demography, Land Use, and Urban Form on West Nile Virus Risk and Human West Nile Virus Incidence in Ottawa, Canada. ( 30615572 )
2019
21
Epidemiologic and phylogenetic analysis of the 2018 West Nile virus (WNV) outbreak in Israel demonstrates human infection of WNV lineage I. ( 30621816 )
2019
22
Surveillance of animal diseases through implementation of a Bayesian spatio-temporal model: A simulation example with neurological syndromes in horses and West Nile Virus. ( 30621904 )
2019
23
West Nile virus-inclusive single-cell RNA sequencing reveals heterogeneity in the type I interferon response within single cells. ( 30626670 )
2019
24
GENETIC DIVERSITY OF YELLOW-BILLED MAGPIES ( PICA NUTALLI) BEFORE AND AFTER A WEST NILE VIRUS EPIDEMIC. ( 30628856 )
2019
25
West Nile virus outbreak in the South of France: Implications for travel medicine. ( 30630052 )
2019
26
Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection. ( 30642926 )
2019
27
An observer blinded, randomized, placebo-controlled, phase I dose escalation trial to evaluate the safety and immunogenicity of an inactivated West Nile virus Vaccine, HydroVax-001, in healthy adults. ( 30661836 )
2019
28
Detection of West Nile virus lineage 1 sequences in blood donors, Punjab Province, Pakistan. ( 30664985 )
2019
29
West Nile Virus Infection in Travelers Returning to United Kingdom from South Africa. ( 30666938 )
2019
30
Cumulative Incidence of West Nile Virus Infection, Continental United States, 1999-2016. ( 30666940 )
2019
31
Acute and Delayed Deaths after West Nile Virus Infection, Texas, USA, 2002-2012. ( 30667356 )
2019
32
First isolation of West Nile virus in Brazil. ( 30672980 )
2019
33
Linking Bird and Mosquito Data to Assess Spatiotemporal West Nile Virus Risk in Humans. ( 30673905 )
2019
34
Epidemiology of West Nile Virus in the Eastern Mediterranean region: A systematic review. ( 30695031 )
2019
35
Comparative fitness of West Nile virus isolated during California epidemics. ( 30716113 )
2019
36
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection. ( 30721061 )
2019
37
Effects of host blood meal source on reproductive output, nutrient reserves and gut microbiome of West Nile virus vector Culex quinquefasciatus. ( 30735684 )
2019
38
Short-term Forecasting of Daily Abundance of West Nile Virus Vectors Culex pipiens-restuans (Diptera: Culicidae) and Aedes vexans Based on Weather Conditions in Southern Québec (Canada). ( 30753555 )
2019
39
Utility of examining fallen stock data to monitor health-related events in equids: application to an outbreak of West Nile Virus in France in 2015. ( 30773844 )
2019
40
West Nile Virus Capsid Protein Interacts With Biologically Relevant Host Lipid Systems. ( 30788291 )
2019
41
Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice. ( 30814992 )
2019
42
Assessment of West Nile virus transmission risk from a weather-dependent epidemiological model and a global sensitivity analysis framework. ( 30844376 )
2019
43
Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals. ( 30845250 )
2019
44
A spatio-temporal individual-based network framework for West Nile virus in the USA: Spreading pattern of West Nile virus. ( 30865618 )
2019
45
Sex differences in cytokine production following West Nile virus infection: Implications for symptom manifestation. ( 30915442 )
2019
46
Effect of overwintering on survival and vector competence of the West Nile virus vector Culex pipiens. ( 30917854 )
2019
47
Stability of West Nile Virus (Flaviviridae: Flavivirus) RNA in Mosquito Excreta. ( 30937448 )
2019
48
The West Nile virus epidemic-occupational insight. ( 30938316 )
2019
49
West Nile virus infections are here! Are we prepared to face another flavivirus epidemic? ( 30942263 )
2019
50
JC virus identified in a patient with persistent and severe West Nile virus disease. ( 30949974 )
2019

Variations for West Nile Virus

ClinVar genetic disease variations for West Nile Virus:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CCR5 NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs) deletion protective,risk factor rs333 GRCh37 Chromosome 3, 46414947: 46414978
2 CCR5 NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs) deletion protective,risk factor rs333 GRCh38 Chromosome 3, 46373456: 46373487

Expression for West Nile Virus

Search GEO for disease gene expression data for West Nile Virus.

Pathways for West Nile Virus

Pathways related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 CCR5 CD209 CFH DDX58 IFIH1 IFITM1
2
Show member pathways
13.13 CCR5 DDX58 IFITM1 IFITM2 IFITM3 IFNA1
3
Show member pathways
12.76 CCR5 DDX58 IFIH1 IFNA1 IRF3 ITGAV
4
Show member pathways
12.52 DDX58 IFIH1 IFNA1 IRF3 TLR3
5
Show member pathways
12.22 DDX58 IFIH1 IRF3 TLR3
6
Show member pathways
12.21 IRF3 ITGAV ITGB3 TLR3
7 12.21 DDX58 IFIH1 IFNA1 IRF3 OAS1 RSAD2
8
Show member pathways
12.01 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 OAS1
9 11.92 CD209 CLEC4M ITGAV ITGB3
10 11.79 CD209 ITGAV ITGB3
11
Show member pathways
11.72 DDX58 IFITM1 IFITM2 IFITM3 IFNA1 IRF3
12 11.58 ITGAV ITGB3 TLR3
13
Show member pathways
10.94 DDX58 IRF3 OAS1
14 10.88 ITGAV ITGB3
15 10.67 ITGAV ITGB3
16 10.57 ITGAV ITGB3

GO Terms for West Nile Virus

Cellular components related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.83 CCR5 CD209 ITGAV ITGB3 TLR3
2 ruffle membrane GO:0032587 9.5 DDX58 ITGAV ITGB3
3 lamellipodium membrane GO:0031258 9.46 ITGAV ITGB3
4 filopodium membrane GO:0031527 9.4 ITGAV ITGB3
5 host cell GO:0043657 9.37 CD209 CLEC4M
6 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 9.26 ITGAV ITGB3
7 alphav-beta3 integrin-HMGB1 complex GO:0035868 9.16 ITGAV ITGB3
8 alphav-beta3 integrin-PKCalpha complex GO:0035866 8.96 ITGAV ITGB3
9 integrin alphav-beta3 complex GO:0034683 8.62 ITGAV ITGB3

Biological processes related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.93 CD209 CFH CLEC4M DDX58 IFIH1 IFITM1
2 type I interferon signaling pathway GO:0060337 9.87 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 OAS1
3 viral entry into host cell GO:0046718 9.86 CD209 CLEC4M ITGAV ITGB3
4 response to virus GO:0009615 9.86 DDX58 IFIH1 IFITM1 IFITM2 IFITM3 OAS1
5 negative regulation of type I interferon production GO:0032480 9.77 DDX58 IFIH1 IRF3
6 negative regulation of viral genome replication GO:0045071 9.77 IFITM1 IFITM2 IFITM3 OAS1 RSAD2
7 response to interferon-gamma GO:0034341 9.74 IFITM1 IFITM2 IFITM3
8 positive regulation of interferon-beta production GO:0032728 9.73 DDX58 IFIH1 IRF3 TLR3
9 viral process GO:0016032 9.73 CCR5 CD209 CFH CLEC4M DDX58 EXOC1
10 negative regulation of viral entry into host cell GO:0046597 9.72 IFITM1 IFITM2 IFITM3
11 cellular response to exogenous dsRNA GO:0071360 9.71 DDX58 IFIH1 TLR3
12 positive regulation of interferon-alpha production GO:0032727 9.7 DDX58 IFIH1 IRF3
13 response to interferon-alpha GO:0035455 9.69 IFITM1 IFITM2 IFITM3
14 cell adhesion mediated by integrin GO:0033627 9.68 ITGAV ITGB3
15 apoptotic cell clearance GO:0043277 9.68 ITGAV ITGB3
16 cell-substrate adhesion GO:0031589 9.68 ITGAV ITGB3
17 positive regulation of tumor necrosis factor secretion GO:1904469 9.67 DDX58 IFIH1
18 viral genome replication GO:0019079 9.67 CD209 CLEC4M
19 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.67 ITGAV ITGB3
20 response to interferon-beta GO:0035456 9.67 IFITM1 IFITM2 IFITM3
21 intracellular transport of virus GO:0075733 9.66 CD209 CLEC4M
22 positive regulation of interferon-alpha secretion GO:1902741 9.66 DDX58 IFIH1
23 negative regulation of lipid storage GO:0010888 9.65 ITGAV ITGB3
24 modulation by virus of host morphology or physiology GO:0019048 9.65 CD209 CLEC4M
25 apolipoprotein A-I-mediated signaling pathway GO:0038027 9.65 ITGAV ITGB3
26 response to exogenous dsRNA GO:0043330 9.65 DDX58 IFNA1 TLR3
27 cell-cell recognition GO:0009988 9.64 CD209 CLEC4M
28 positive regulation of response to cytokine stimulus GO:0060760 9.64 DDX58 IFIH1
29 positive regulation of interferon-beta secretion GO:0035549 9.63 DDX58 IFIH1
30 virion attachment to host cell GO:0019062 9.63 CD209 CLEC4M
31 detection of virus GO:0009597 9.63 DDX58 IFIH1 TLR3
32 negative regulation of lipid transport GO:0032369 9.62 ITGAV ITGB3
33 MDA-5 signaling pathway GO:0039530 9.62 IFIH1 IRF3
34 negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715 9.61 ITGAV ITGB3
35 peptide antigen transport GO:0046968 9.61 CD209 CLEC4M
36 cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 9.59 DDX58 IFIH1
37 negative regulation of lipoprotein metabolic process GO:0050748 9.58 ITGAV ITGB3
38 regulation of type III interferon production GO:0034344 9.58 DDX58 IFIH1
39 defense response to virus GO:0051607 9.36 DDX58 EXOC1 IFIH1 IFITM1 IFITM2 IFITM3
40 immune system process GO:0002376 10.06 CD209 CLEC4M DDX58 IFIH1 IFITM1 IRF3

Molecular functions related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor I binding GO:0031994 9.4 ITGAV ITGB3
2 virion binding GO:0046790 9.37 CD209 CLEC4M
3 coreceptor activity GO:0015026 9.33 CCR5 ITGAV ITGB3
4 C-X3-C chemokine binding GO:0019960 9.32 ITGAV ITGB3
5 neuregulin binding GO:0038132 9.26 ITGAV ITGB3
6 double-stranded RNA binding GO:0003725 9.26 DDX58 IFIH1 OAS1 TLR3
7 virus receptor activity GO:0001618 9.02 CCR5 CD209 CLEC4M ITGAV ITGB3
8 protein binding GO:0005515 10.34 CCR5 CD209 CFH DDX58 EXOC1 IFIH1

Sources for West Nile Virus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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