MCID: WST005
MIFTS: 57

West Nile Virus

Categories: Genetic diseases, Rare diseases, Neuronal diseases, Infectious diseases

Aliases & Classifications for West Nile Virus

MalaCards integrated aliases for West Nile Virus:

Name: West Nile Virus 57 76 53 43
West Nile Virus, Susceptibility to 57 29 13 6 40
Encephalitis, West Nile Fever 73
West Nile Viral Infection 73
Wnv, Susceptibility to 57
West-Nile Encephalitis 59
West Nile Fever 73
West-Nile Fever 59
Wnv 57

Characteristics:

Orphanet epidemiological data:

59
west-nile encephalitis
Inheritance: Not applicable; Prevalence: 1-9/1000000 (United States),<1/1000000 (Europe); Age of onset: All ages; Age of death: any age;

Classifications:



External Ids:

OMIM 57 610379
Orphanet 59 ORPHA83476
UMLS via Orphanet 74 C0751583 C0043124
ICD10 via Orphanet 34 A92.3
UMLS 73 C1096184

Summaries for West Nile Virus

MedlinePlus : 43 West Nile virus (WNV) is an infectious disease that first appeared in the United States in 1999. Infected mosquitoes spread the virus that causes it. People who get WNV usually have no symptoms or mild symptoms. The symptoms include a fever, headache, body aches, skin rash, and swollen lymph glands. They can last a few days to several weeks, and usually go away on their own. If West Nile virus enters the brain, however, it can be life-threatening. It may cause inflammation of the brain, called encephalitis, or inflammation of the tissue that surrounds the brain and spinal cord, called meningitis. A physical exam, health history and laboratory tests can diagnose it. Older people and those with weakened immune systems are most at risk. There are no specific vaccines or treatments for human WNV disease. The best way to avoid WNV is to prevent mosquito bites: Use insect repellent Get rid of mosquito breeding sites by emptying standing water from flower pots, buckets or barrels Stay indoors between dusk and dawn, when mosquitoes are most active Use screens on windows to keep mosquitoes out NIH: National Institute of Allergy and Infectious Diseases

MalaCards based summary : West Nile Virus, also known as west nile virus, susceptibility to, is related to japanese encephalitis and rift valley fever, and has symptoms including back pain, fever and headache. An important gene associated with West Nile Virus is CCR5 (C-C Motif Chemokine Receptor 5 (Gene/Pseudogene)), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Glycine and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotype is immune system.

OMIM : 57 WNV is an enveloped, neurotropic, single-stranded sense RNA flavivirus that is naturally maintained in a zoonotic cycle between avian hosts and mosquito vectors. The virus was first isolated from a Ugandan woman in 1937 and subsequently emerged in Europe and, in 1999, in New York, with eventual spread throughout North America. WNV causes a spectrum of disease ranging from acute fever to lethal encephalitis. Susceptibility to WNV is increased in the elderly and in immunocompromised individuals (summary by Diamond and Klein (2006) and Glass et al. (2005)). (610379)

Wikipedia : 76 West Nile virus (WNV) is a... more...

Related Diseases for West Nile Virus

Diseases related to West Nile Virus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 japanese encephalitis 30.5 CD209 CLEC4M DDX58 TLR3
2 rift valley fever 29.8 CD209 IFITM3 MX1
3 tick-borne encephalitis 29.6 CCR5 CD209 OAS1 TLR3
4 severe acute respiratory syndrome 29.6 CD209 CLEC4M IFNA1 IRF3
5 encephalitis 29.4 CCR5 CD209 CLEC4M DDX58 IRF3 RSAD2
6 yellow fever 29.2 CCR5 OAS1 RSAD2
7 hepatitis c 28.8 CLEC4M DDX58 IFNA1 IRF3 TLR3
8 measles 28.7 CD209 DDX58 IFIH1 IFNA1 TLR3
9 dengue virus 28.4 CD209 DDX58 EXOC1 IFIH1 IFITM1 IFITM2
10 human immunodeficiency virus type 1 28.2 CCR5 CD209 CLEC4M IFNA1 IRF3 TLR3
11 hepatitis c virus 27.9 CCR5 CLEC4M DDX58 IFIH1 IFITM1 IRF3
12 influenza 25.0 DDX58 IFIH1 IFITM1 IFITM2 IFITM3 IFNA1
13 west nile encephalitis 11.8
14 west nile fever 11.8
15 kunjin encephalitis 11.3
16 st. louis encephalitis 10.4
17 meningoencephalitis 10.4
18 chorioretinitis 10.4
19 meningitis 10.3
20 retinitis 10.2
21 poliomyelitis 10.2
22 chikungunya 10.2
23 neuronitis 10.2
24 coccidioidomycosis 10.1
25 vasculitis 10.1
26 type i 10.1
27 singleton-merten syndrome 10.1 DDX58 IFIH1
28 aging 10.1
29 aceruloplasminemia 10.1
30 ataxia-oculomotor apraxia 3 10.1
31 hepatitis 10.1
32 eastern equine encephalitis 10.1
33 murray valley encephalitis 10.1
34 retinal vasculitis 10.1
35 aseptic meningitis 10.1
36 malaria 10.0
37 hepatitis b 10.0
38 leukemia 10.0
39 choroiditis 10.0
40 crimean-congo hemorrhagic fever 10.0
41 quadriplegia 10.0
42 spinal cord disease 10.0
43 kidney disease 10.0
44 hemorrhagic fever 10.0
45 myoclonus 10.0
46 newcastle disease 10.0 DDX58 IFNA1 IRF3
47 myositis 9.8
48 myasthenia gravis 9.8
49 neuroblastoma 9.8
50 leukemia, acute lymphoblastic 9.8

Graphical network of the top 20 diseases related to West Nile Virus:



Diseases related to West Nile Virus

Symptoms & Phenotypes for West Nile Virus

Clinical features from OMIM:

610379

UMLS symptoms related to West Nile Virus:


back pain, fever, headache, pain, pruritus, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

MGI Mouse Phenotypes related to West Nile Virus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.36 CCR5 CFH CLEC4M DDX58 IFIH1 IFITM3

Drugs & Therapeutics for West Nile Virus

Drugs for West Nile Virus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
2 Antibodies Phase 2,Phase 1
3 gamma-Globulins Phase 2,Phase 1
4 Immunoglobulin G Phase 2,Phase 1
5 Immunoglobulins Phase 2,Phase 1
6 Immunoglobulins, Intravenous Phase 2,Phase 1
7 Rho(D) Immune Globulin Phase 2,Phase 1
8 Pharmaceutical Solutions Phase 1, Phase 2,Phase 2
9 Vaccines Phase 2,Phase 1
10 Antibodies, Monoclonal Phase 2,Phase 1
11
Aluminum sulfate Approved Phase 1 10043-01-3
12
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
13 Adjuvants, Immunologic Phase 1
14 Antacids Phase 1
15 Anti-Ulcer Agents Phase 1
16 Gastrointestinal Agents Phase 1

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Omr-IgG-am(Trademark) for Treating Patients With or at High Risk for West Nile Virus Disease Completed NCT00069316 Phase 2 Omr-IgG-am
2 IVIG - West Nile Encephalitis: Safety and Efficacy Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
3 Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults Completed NCT00746798 Phase 2
4 Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults Completed NCT00442169 Phase 2
5 Treatment of West Nile Virus With MGAWN1 Terminated NCT00927953 Phase 2
6 Phase 1 Trial of Inactivated West Nile Virus Vaccine Completed NCT02337868 Phase 1
7 Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of Age Completed NCT02186626 Phase 1
8 Phase I Study of West Nile Virus Vaccine Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
9 A Trial to Evaluate the Safety of a Single Intravenous Infusion of MGAWN1 in Healthy Adults Completed NCT00515385 Phase 1 MGAWN1;MGAWN1
10 Vaccine to Prevent West Nile Virus Disease Completed NCT00106769 Phase 1 VRC-WNVDNA017-00-VP
11 Pharmacokinetic Study in Cerebral Spinal Fluid After a Single Dose of AVI-4020 Completed NCT00387283 Phase 1 AVI-4020 Injection
12 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults Completed NCT00537147 Phase 1
13 Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3'delta30) in Healthy Adults Completed NCT00094718 Phase 1
14 Safety Study of HBV-002 West Nile Vaccine in Healthy Adults Completed NCT00707642 Phase 1
15 Pharmacokinetic Study of a Single Dose of AVI-4065 in Cerebral Spinal Fluid Completed NCT00381433 Phase 1 AVI-4065 Injection
16 An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease Terminated NCT00091845 Phase 1 AVI-4020 Injection
17 West Nile Virus Natural History Completed NCT00138463
18 Natural History of West Nile Virus Infection Completed NCT00069303
19 Surveillance of Summer Febrile Syndromes of Viral Origin in South of France Completed NCT00842166 Not Applicable
20 VRC 300: Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases Completed NCT00068926
21 Organ Transplant Infection Prevention and Detection Project Completed NCT00177801
22 Retrovirus Epidemiology Donor Study-II (REDS-II) Completed NCT00097006
23 Cohort of Patients Infected by an Arbovirus Recruiting NCT01099852
24 Expanded Access to MGAWN1 in Subjects With Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection; or Substantial Accidental Exposure No longer available NCT01206504

Search NIH Clinical Center for West Nile Virus

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for West Nile Virus

Genetic tests related to West Nile Virus:

# Genetic test Affiliating Genes
1 West Nile Virus, Susceptibility to 29 CCR5

Anatomical Context for West Nile Virus

MalaCards organs/tissues related to West Nile Virus:

41
Brain, Testes, Spinal Cord, Skin, T Cells, B Cells, Kidney

Publications for West Nile Virus

Articles related to West Nile Virus:

(show top 50) (show all 847)
# Title Authors Year
1
Prevalence of Usutu and West Nile virus antibodies in human sera, Modena, Italy, 2012. ( 29797606 )
2018
2
First isolation of West Nile virus in Zambia from mosquitoes. ( 29722174 )
2018
3
Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge <i>Amphimedon chloros</i> with <i>In Vitro</i> Inhibitory Activity against the West Nile Virus NS3 Protease. ( 29912151 )
2018
4
Does intra-individual neurocognitive variability relate to neuroinvasive disease and quality of life in West Nile Virus? ( 29696579 )
2018
5
Selective constraint and adaptive potential of West Nile virus within and among naturally infected avian hosts and mosquito vectors. ( 29942654 )
2018
6
West Nile Virus and Usutu Virus Monitoring of Wild Birds in Germany. ( 29361762 )
2018
7
Ovicidal and Larvicidal Effects of Garlic and Asafoetida Essential Oils Against West Nile Virus Vectors. ( 29718505 )
2018
8
Experimental evaluation of infection, dissemination, and transmission rates for two West Nile virus strains in European Aedes japonicus under a fluctuating temperature regime. ( 29705877 )
2018
9
Evaluation of real-time reverse-transcription loop-mediated isothermal amplification assay for clinical diagnosis of West Nile virus in patients. ( 29923519 )
2018
10
Splenic macrophages are required for protective innate immunity against West Nile virus. ( 29408905 )
2018
11
West Nile Virus and Other Nationally Notifiable Arboviral Diseases - United States, 2016. ( 29324725 )
2018
12
A four-year survey (2011-2014) of West Nile virus infection in humans, mosquitoes and birds, including the 2012 meningoencephalitis outbreak in Tunisia. ( 29535295 )
2018
13
Increased Human Incidence of West Nile Virus Disease near Rice Fields in California but Not in Southern United States. ( 29714160 )
2018
14
Population genetic structure of the Culex pipiens (Diptera: Culicidae) complex, vectors of West Nile virus, in five habitats. ( 29301567 )
2018
15
Enhanced production and immunological characterization of recombinant West Nile virus envelope domain III protein. ( 29768182 )
2018
16
Absence of protection from West Nile virus disease and adverse effects in red legged partridges after non-structural NS1 protein administration. ( 29406280 )
2018
17
West Nile virus and other mosquito-borne viruses present in Eastern Europe. ( 29979950 )
2018
18
Attenuation of West Nile Virus NS2B/NS3 Protease by Amino Terminal Copper and Nickel Binding (ATCUN) Peptides. ( 29301071 )
2018
19
Serosurvey of West Nile virus in household-reared pigeons in Bauchi metropolis, Nigeria. ( 29788268 )
2018
20
Improving the prediction of arbovirus outbreaks: A comparison of climate-driven models for West Nile virus in an endemic region of the United States. ( 29727611 )
2018
21
Exposure to West Nile virus and tick-borne encephalitis virus in dogs in Spain. ( 29322674 )
2018
22
Correction: An ImmunoSignature test distinguishes Trypanosoma cruzi, hepatitis B, hepatitis C and West Nile virus seropositivity among asymptomatic blood donors. ( 29389963 )
2018
23
Antibodies to West Nile virus in Mexican pigs. ( 29916452 )
2018
24
Seroprevalence of Dengue Virus, West Nile Virus, Chikungunya Virus, and Zika Virus in International Travelers Attending a Travel and Migration Center in 2015-2017, Southern Italy. ( 29683399 )
2018
25
A monoclonal antibody to DIII E protein allowing the differentiation of West Nile virus from other flaviviruses by a Lateral Flow Assay. ( 29958922 )
2018
26
Ocular manifestations of emerging arboviruses: Dengue fever, Chikungunya, Zika virus, West Nile virus, and yellow fever. ( 29929827 )
2018
27
Identification of genetic variants associated with dengue or West Nile virus disease: a systematic review and meta-analysis. ( 29929468 )
2018
28
Mating behavior of the West Nile virus vector Culex pipiens - role of behavioral asymmetries. ( 29288628 )
2018
29
Phospholipase A2 activity during the replication cycle of the flavivirus West Nile virus. ( 29709018 )
2018
30
Mosquito community influences West Nile virus seroprevalence in wild birds: implications for the risk of spillover into human populations. ( 29422507 )
2018
31
Increases in the competitive fitness of West Nile virus isolates after introduction into California. ( 29195094 )
2018
32
Experimental transmission of West Nile Virus and Rift Valley Fever Virus by Culex pipiens from Lebanon. ( 29324834 )
2018
33
Understanding Knowledge, Attitudes, and Behaviors Toward West Nile Virus Prevention: A Survey of High-Risk Adults in Maryland. ( 29336697 )
2018
34
Inhibition of West Nile virus Replication by Bifunctional siRNA Targeting the NS2A and NS5 Conserved Region. ( 29874999 )
2018
35
Nucleic Acid Amplification Test For Detection Of West Nile Virus Infection In Pakistani Blood Donors. ( 29330974 )
2017
36
West Nile virus in Ontario, Canada: A twelve-year analysis of human case prevalence, mosquito surveillance, and climate data. ( 28829827 )
2017
37
Exploring vector-borne infection ecology in multi-host communities: A case study of West Nile virus. ( 27986465 )
2017
38
Epidemiologic and clinical parameters of West Nile virus infections in humans: a scoping review. ( 28877682 )
2017
39
First Serological Evidence of West Nile Virus in Horses and Dogs from Corsica Island, France. ( 28075236 )
2017
40
Valosin-containing protein (VCP/p97) plays a role in the replication of West Nile virus. ( 27914931 )
2017
41
Minocycline has anti-inflammatory effects and reduces cytotoxicity in an ex vivo spinal cord slice culture model of West Nile virus infection. ( 28878079 )
2017
42
Zika virus infection confers protection against West Nile virus challenge in mice. ( 28928416 )
2017
43
Transmission of West Nile Virus Through a Hematopoietic Stem Cell Transplant. ( 29309636 )
2017
44
Detection of West Nile virus in six mosquito species in synchrony with seroconversion among sentinel chickens in India. ( 28061903 )
2017
45
The impact of weather and storm water management ponds on the transmission of West Nile virus. ( 28878963 )
2017
46
Comparison of assays for the detection of West Nile virus antibodies in equine serum after natural infection or vaccination. ( 28063471 )
2017
47
West Nile virus meningitis in a patient with human immunodeficiency virus type 1 infection. ( 28831299 )
2017
48
MAVS is essential for primary CD4+ T cell immunity but not for recall T cell responses following an attenuated West Nile virus infection. ( 28077630 )
2017
49
A recombinant fusion protein consisting of West Nile virus envelope domain III fused in-frame with equine CD40 ligand induces antiviral immune responses in horses. ( 28062007 )
2017
50
Transcriptomic Analyses Reveal Differential Gene Expression of Immune and Cell Death Pathways in the Brains of Mice Infected with West Nile Virus and Chikungunya Virus. ( 28861067 )
2017

Variations for West Nile Virus

ClinVar genetic disease variations for West Nile Virus:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CCR5 NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs) deletion protective,risk factor rs333 GRCh37 Chromosome 3, 46414947: 46414978
2 CCR5 NM_000579.3(CCR5): c.554_585del32 (p.Ser185Ilefs) deletion protective,risk factor rs333 GRCh38 Chromosome 3, 46373456: 46373487

Expression for West Nile Virus

Search GEO for disease gene expression data for West Nile Virus.

Pathways for West Nile Virus

Pathways related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 CCR5 CD209 CFH DDX58 IFIH1 IFITM1
2
Show member pathways
13.17 CCR5 DDX58 IFITM1 IFITM2 IFITM3 IFNA1
3
Show member pathways
12.8 IFNA1 IRF3 ITGAV ITGB3 MX1 TLR3
4
Show member pathways
12.57 DDX58 IFIH1 IFNA1 IRF3 TLR3
5 12.46 DDX58 IFIH1 IFNA1 IRF3 OAS1 RSAD2
6
Show member pathways
12.45 CCR5 DDX58 IFIH1 IFNA1 IRF3 TLR3
7
Show member pathways
12.45 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 MX1
8
Show member pathways
12.34 CD209 CLEC4M DDX58 IFIH1 IFNA1 IRF3
9
Show member pathways
12.26 DDX58 IFIH1 IRF3 TLR3
10
Show member pathways
12.24 IRF3 ITGAV ITGB3 TLR3
11 11.96 CD209 CLEC4M ITGAV ITGB3
12 11.95 DDX58 IFNA1 IRF3 OAS1 TLR3
13 11.82 CD209 ITGAV ITGB3
14
Show member pathways
11.77 DDX58 IFITM1 IFITM2 IFITM3 IFNA1 IRF3
15 11.63 ITGAV ITGB3 TLR3
16
Show member pathways
11.03 DDX58 IRF3 MX1 OAS1
17 10.91 ITGAV ITGB3
18 10.7 ITGAV ITGB3
19 10.62 ITGAV ITGB3

GO Terms for West Nile Virus

Cellular components related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.83 CCR5 CD209 ITGAV ITGB3 TLR3
2 ruffle membrane GO:0032587 9.5 DDX58 ITGAV ITGB3
3 lamellipodium membrane GO:0031258 9.46 ITGAV ITGB3
4 filopodium membrane GO:0031527 9.37 ITGAV ITGB3
5 alphav-beta3 integrin-IGF-1-IGF1R complex GO:0035867 9.26 ITGAV ITGB3
6 alphav-beta3 integrin-HMGB1 complex GO:0035868 9.16 ITGAV ITGB3
7 alphav-beta3 integrin-PKCalpha complex GO:0035866 8.96 ITGAV ITGB3
8 integrin alphav-beta3 complex GO:0034683 8.62 ITGAV ITGB3
9 membrane GO:0016020 10.28 CCR5 CD209 CLEC4M DDX58 EXOC1 IFITM1

Biological processes related to West Nile Virus according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 defense response GO:0006952 9.94 CCR5 IFNA1 MX1 TLR3
2 type I interferon signaling pathway GO:0060337 9.92 IFITM1 IFITM2 IFITM3 IFNA1 IRF3 MX1
3 viral entry into host cell GO:0046718 9.87 CD209 CLEC4M ITGAV ITGB3
4 negative regulation of viral genome replication GO:0045071 9.85 IFITM1 IFITM2 IFITM3 MX1 OAS1 RSAD2
5 response to virus GO:0009615 9.81 DDX58 IFIH1 IFITM1 IFITM2 IFITM3 MX1
6 negative regulation of type I interferon production GO:0032480 9.8 DDX58 IFIH1 IRF3
7 innate immune response GO:0045087 9.8 CD209 CFH CLEC4M DDX58 IFIH1 IFITM1
8 response to exogenous dsRNA GO:0043330 9.78 DDX58 IFNA1 IRF3 TLR3
9 response to interferon-gamma GO:0034341 9.75 IFITM1 IFITM2 IFITM3
10 negative regulation of viral entry into host cell GO:0046597 9.73 IFITM1 IFITM2 IFITM3
11 positive regulation of interferon-beta production GO:0032728 9.73 DDX58 IFIH1 IRF3 TLR3
12 cellular response to exogenous dsRNA GO:0071360 9.72 DDX58 IFIH1 TLR3
13 response to biotic stimulus GO:0009607 9.71 IFITM1 IFITM2 IFITM3
14 positive regulation of interferon-alpha production GO:0032727 9.7 DDX58 IFIH1 IRF3
15 heterotypic cell-cell adhesion GO:0034113 9.69 ITGAV ITGB3
16 apoptotic cell clearance GO:0043277 9.69 ITGAV ITGB3
17 response to interferon-alpha GO:0035455 9.69 IFITM1 IFITM2 IFITM3
18 cell-substrate adhesion GO:0031589 9.68 ITGAV ITGB3
19 cell adhesion mediated by integrin GO:0033627 9.68 ITGAV ITGB3
20 viral genome replication GO:0019079 9.68 CD209 CLEC4M
21 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.68 ITGAV ITGB3
22 positive regulation of tumor necrosis factor secretion GO:1904469 9.67 DDX58 IFIH1
23 negative regulation of lipid storage GO:0010888 9.67 ITGAV ITGB3
24 positive regulation of interferon-alpha secretion GO:1902741 9.67 DDX58 IFIH1
25 response to interferon-beta GO:0035456 9.67 IFITM1 IFITM2 IFITM3
26 modulation by virus of host morphology or physiology GO:0019048 9.66 CD209 CLEC4M
27 cellular response to dsRNA GO:0071359 9.66 IRF3 TLR3
28 cell-cell recognition GO:0009988 9.65 CD209 CLEC4M
29 positive regulation of response to cytokine stimulus GO:0060760 9.65 DDX58 IFIH1
30 apolipoprotein A-I-mediated signaling pathway GO:0038027 9.65 ITGAV ITGB3
31 positive regulation of interferon-beta secretion GO:0035549 9.64 DDX58 IFIH1
32 negative regulation of lipid transport GO:0032369 9.63 ITGAV ITGB3
33 virion attachment to host cell GO:0019062 9.63 CD209 CLEC4M
34 detection of virus GO:0009597 9.63 DDX58 IFIH1 TLR3
35 negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715 9.62 ITGAV ITGB3
36 peptide antigen transport GO:0046968 9.61 CD209 CLEC4M
37 MDA-5 signaling pathway GO:0039530 9.61 IFIH1 IRF3
38 negative regulation of lipoprotein metabolic process GO:0050748 9.6 ITGAV ITGB3
39 regulation of type III interferon production GO:0034344 9.59 DDX58 IFIH1
40 cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039528 9.58 DDX58 IFIH1
41 defense response to virus GO:0051607 9.4 DDX58 EXOC1 IFIH1 IFITM1 IFITM2 IFITM3
42 immune system process GO:0002376 10.1 CD209 CLEC4M DDX58 IFIH1 IFITM1 IRF3
43 viral process GO:0016032 10.03 CCR5 CD209 CFH CLEC4M DDX58 EXOC1

Molecular functions related to West Nile Virus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.95 DDX58 IFIH1 IRF3 ITGB3 MX1 TLR3
2 mannose binding GO:0005537 9.46 CD209 CLEC4M
3 insulin-like growth factor I binding GO:0031994 9.43 ITGAV ITGB3
4 virion binding GO:0046790 9.4 CD209 CLEC4M
5 coreceptor activity GO:0015026 9.33 CCR5 ITGAV ITGB3
6 C-X3-C chemokine binding GO:0019960 9.32 ITGAV ITGB3
7 neuregulin binding GO:0038132 9.26 ITGAV ITGB3
8 double-stranded RNA binding GO:0003725 9.26 DDX58 IFIH1 OAS1 TLR3
9 virus receptor activity GO:0001618 9.02 CCR5 CD209 CLEC4M ITGAV ITGB3
10 protein binding GO:0005515 10.32 CCR5 CD209 CFH CLEC4M DDX58 EXOC1

Sources for West Nile Virus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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