MCID: WST009
MIFTS: 20

West Nile Virus Encephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for West Nile Virus Encephalitis

MalaCards integrated aliases for West Nile Virus Encephalitis:

Name: West Nile Virus Encephalitis 52

Classifications:



Summaries for West Nile Virus Encephalitis

NIH Rare Diseases : 52 West Nile encephalitis is a form of West Nile virus that affects the neurological system . Signs and symptoms may include headache, fever, neck stiffness, disorientation, tremors, seizures , paralysis, or coma. West Nile virus is generally spread to humans by infected mosquitos. West Nile encephalitis, specifically, occurs when the virus crosses the blood-brain barrier and infects the central nervous system . Although West Nile encephalitis can affect anyone, people who are over age 60, have received an organ transplant, or are affected by certain medical conditions such as cancer , diabetes, hypertension , and kidney disease have the highest risk of developing the condition. Treatment is supportive and hospitalization may be required to address the associated symptoms. Recovery may take several weeks or months and some of the neurologic effects may be permanent.

MalaCards based summary : West Nile Virus Encephalitis is related to west nile virus and encephalitis. An important gene associated with West Nile Virus Encephalitis is MIF (Macrophage Migration Inhibitory Factor). The drugs Glycine and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and t cells.

Related Diseases for West Nile Virus Encephalitis

Diseases in the West Nile Encephalitis family:

West Nile Virus Encephalitis

Diseases related to West Nile Virus Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 west nile virus 11.1
2 encephalitis 11.1
3 meningoencephalitis 10.6
4 west nile encephalitis 10.5
5 viral encephalitis 10.5
6 west nile virus infection 10.5
7 west nile fever 10.4
8 poliomyelitis 10.3
9 tremor 10.3
10 aseptic meningitis 10.2
11 status epilepticus 10.2
12 subacute delirium 10.2
13 opsoclonus-myoclonus syndrome 10.2
14 meningitis and encephalitis 10.2
15 myoclonus 10.2
16 leukemia, chronic lymphocytic 10.1
17 myositis 10.1
18 small cell cancer of the lung 10.1
19 ocular motor apraxia 10.1
20 ataxia and polyneuropathy, adult-onset 10.1
21 endometrial cancer 10.1
22 diabetes mellitus, ketosis-prone 10.1
23 dengue virus 10.1
24 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.1
25 chikungunya 10.1
26 exanthem 10.1
27 purpura fulminans 10.1
28 st. louis encephalitis 10.1
29 microcephaly 10.1
30 disseminated intravascular coagulation 10.1
31 choroiditis 10.1
32 quadriplegia 10.1
33 dilated cardiomyopathy 10.1
34 neuroendocrine carcinoma 10.1
35 orchitis 10.1
36 myelitis 10.1
37 purpura 10.1
38 paraplegia 10.1
39 conjunctivitis 10.1
40 myocarditis 10.1
41 measles 10.1
42 viral infectious disease 10.1
43 meningitis 10.1
44 yellow fever 10.1
45 multifocal choroiditis 10.1
46 transverse myelitis 10.1
47 autonomic dysfunction 10.1
48 dysphagia 10.1
49 encephalopathy 10.1
50 posttransplant acute limbic encephalitis 10.1

Graphical network of the top 20 diseases related to West Nile Virus Encephalitis:



Diseases related to West Nile Virus Encephalitis

Symptoms & Phenotypes for West Nile Virus Encephalitis

Drugs & Therapeutics for West Nile Virus Encephalitis

Drugs for West Nile Virus Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycine Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 56-40-6 750
2 Immunoglobulins Phase 2
3 Antibodies Phase 2
4 Rho(D) Immune Globulin Phase 2
5 gamma-Globulins Phase 2
6 Immunoglobulins, Intravenous Phase 2
7 Immunoglobulin G Phase 2
8 Pharmaceutical Solutions Phase 1, Phase 2
9 Immunologic Factors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (Omr-IgG-am) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus(WNV) Completed NCT00069316 Phase 2 Omr-IgG-am
2 A Phase I/II Randomized, Placebo-Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin G (OMR-IGG-AM) Containing High Anti-West Nile Virus Antibody Titers in Patients With, or at High Risk for Progression to West Nile Virus (WNV) Encephalitis and/or Myelitis Completed NCT00068055 Phase 1, Phase 2 Omr-lgG-am;Polygam® S/D;Placebo
3 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303

Search NIH Clinical Center for West Nile Virus Encephalitis

Genetic Tests for West Nile Virus Encephalitis

Anatomical Context for West Nile Virus Encephalitis

MalaCards organs/tissues related to West Nile Virus Encephalitis:

40
Brain, Kidney, T Cells, Heart, Eye, Lung, Monocytes

Publications for West Nile Virus Encephalitis

Articles related to West Nile Virus Encephalitis:

(show top 50) (show all 127)
# Title Authors PMID Year
1
Dancing eyes syndrome from West Nile virus encephalitis. 61
32371410 2020
2
Epidemiology, management, and graft outcomes after West Nile virus encephalitis in kidney transplant recipients. 61
32386074 2020
3
Diagnosis of West Nile virus encephalitis in a returned traveller. 61
31736076 2019
4
West Nile virus encephalitis in a young immunocompetent female in Omaha Nebraska. 61
30881858 2019
5
A case of West Nile virus encephalitis accompanied by diabetic ketoacidosis and rhabdomyolysis. 61
30815360 2019
6
Sinus Bradycardia and QT Interval Prolongation in West Nile Virus Encephalitis: A Case Report. 61
30868034 2019
7
West Nile Virus Encephalitis in Haematological Setting: Report of Two Cases and a Brief Review of the Literature. 61
31205637 2019
8
West Nile virus encephalitis in GATA2 deficiency. 61
30697248 2019
9
Z-DNA-Binding Protein 1 Is Critical for Controlling Virus Replication and Survival in West Nile Virus Encephalitis. 61
31572318 2019
10
Lazarus Effect of High Dose Corticosteroids in a Patient With West Nile Virus Encephalitis: A Coincidence or a Clue? 61
31106205 2019
11
West-Nile virus encephalitis in an immunocompetent pediatric patient: successful recovery. 61
30458831 2018
12
Rapidly progressive neurologic decline and morbilliform rash presenting in a patient with lymphoma. 61
30613373 2018
13
Brought Down by a Mosquito? West Nile Virus Encephalitis. 61
29571980 2018
14
Myelopathy in West Nile virus encephalitis: Report of a case and review of literature. 61
30124385 2018
15
Correction for Kumar et al., "Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis". 61
30018145 2018
16
Turning Up Your Nose for a Flaviviral Encephalitis Cure. 61
29649437 2018
17
Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis. 61
28356527 2017
18
Identification of host genes leading to West Nile virus encephalitis in mice brain using RNA-seq analysis. 61
27211830 2016
19
Purpura fulminans associated with acute West Nile virus encephalitis. 61
26686320 2016
20
Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis. 61
26638028 2016
21
West Nile Virus Encephalitis in a Patient with Neuroendocrine Carcinoma. 61
27516915 2016
22
A Security Guard With West Nile Virus Encephalitis. 61
26245464 2016
23
West Nile Virus Encephalitis 16 Years Later. 61
26276026 2015
24
Fatal West Nile Virus Encephalitis in a Heart Transplant Recipient. 61
25994169 2015
25
West Nile Virus Encephalitis: The First Human Case Recorded in Brazil. 61
26055749 2015
26
Anti-inflammatory activity of intravenous immunoglobulins protects against West Nile virus encephalitis. 61
25667322 2015
27
Delayed-onset flaccid paralysis related to west Nile virus reactivation following treatment with rituximab: a case report. 61
25427863 2014
28
IL-1R1 signaling regulates CXCL12-mediated T cell localization and fate within the central nervous system during West Nile Virus encephalitis. 61
25200953 2014
29
Review of West Nile virus epidemiology in Italy and report of a case of West Nile virus encephalitis. 61
25139182 2014
30
Pearls & oy-sters: bilateral thalamic involvement in West Nile virus encephalitis. 61
25002571 2014
31
Dancing eyes dancing feet syndrome-a report of two cases. 61
24995204 2014
32
Opsoclonus myoclonus syndrome: an unusual presentation for West Nile virus encephalitis. 61
24688189 2014
33
West nile virus encephalitis induced opsoclonus-myoclonus syndrome. 61
24987503 2014
34
The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west Nile virus encephalitis. 61
24173226 2014
35
ELF4 is critical for induction of type I interferon and the host antiviral response. 61
24185615 2013
36
Fatal transplant-associated west nile virus encephalitis and public health investigation-california, 2010. 61
23823653 2013
37
Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis. 61
23302887 2013
38
IL-1R1 is required for dendritic cell-mediated T cell reactivation within the CNS during West Nile virus encephalitis. 61
23460727 2013
39
Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages. 61
23111065 2012
40
[A fatal case of West Nile virus encephalitis]. 61
22951662 2012
41
West Nile virus presenting as flaccid paralysis: Case report and literature review. 61
27326299 2012
42
Impaired virus clearance, compromised immune response and increased mortality in type 2 diabetic mice infected with West Nile virus. 61
22953001 2012
43
West Nile Virus encephalitis in intensive care: a small mosquito, a tremendous danger. 61
21597448 2011
44
Novel strategies to improve DNA vaccine immunogenicity. 61
22023477 2011
45
West Nile virus encephalitis acquired via liver transplantation and clinical response to intravenous immunoglobulin: case report and review of the literature. 61
21235711 2011
46
Repeated in vivo stimulation of T and B cell responses in old mice generates protective immunity against lethal West Nile virus encephalitis. 61
21339368 2011
47
Chemokine receptor Ccr2 is critical for monocyte accumulation and survival in West Nile virus encephalitis. 61
21131425 2011
48
Seronegative naturally acquired West Nile virus encephalitis in a renal and pancreas transplant recipient. 61
20576021 2010
49
TNF-alpha-dependent regulation of CXCR3 expression modulates neuronal survival during West Nile virus encephalitis. 61
20579746 2010
50
High titer human immunoglobulin as a specific therapy against West Nile virus encephalitis. 61
19946208 2010

Variations for West Nile Virus Encephalitis

Expression for West Nile Virus Encephalitis

Search GEO for disease gene expression data for West Nile Virus Encephalitis.

Pathways for West Nile Virus Encephalitis

GO Terms for West Nile Virus Encephalitis

Sources for West Nile Virus Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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