MCID: WST010
MIFTS: 32

West Nile Virus Infection

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for West Nile Virus Infection

MalaCards integrated aliases for West Nile Virus Infection:

Name: West Nile Virus Infection 52 3 32

Classifications:



External Ids:

ICD10 32 A92.3

Summaries for West Nile Virus Infection

CDC : 3 West Nile virus (WNV) is the leading cause of mosquito-borne disease in the continental United States. It is most commonly spread to people by the bite of an infected mosquito. Cases of WNV occur during mosquito season, which starts in the summer and continues through fall. There are no vaccines to prevent or medications to treat WNV in people. Fortunately, most people infected with WNV do not feel sick. About 1 in 5 people who are infected develop a fever and other symptoms. About 1 out of 150 infected people develop a serious, sometimes fatal, illness. You can reduce your risk of WNV by using insect repellent and wearing long-sleeved shirts and long pants to prevent mosquito bites.

MalaCards based summary : West Nile Virus Infection is related to west nile virus and west nile fever. An important gene associated with West Nile Virus Infection is CCR5 (C-C Motif Chemokine Receptor 5), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Human cytomegalovirus infection. The drugs Rho(D) Immune Globulin and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and spinal cord.

Related Diseases for West Nile Virus Infection

Diseases related to West Nile Virus Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 west nile virus 32.9 IRF3 CCR5
2 west nile fever 32.1 OAS1 CCR5
3 west nile encephalitis 31.2 OAS1 CCR5
4 encephalitis 31.1 IRF3 CCR5 CCL5
5 tick-borne encephalitis 30.6 OAS1 CCR5
6 neuritis 30.3 CCR5 CCL5
7 chikungunya 30.3 OAS1 CCL5
8 yellow fever 30.1 OAS1 CCR5 CCL5
9 rabies 29.9 IRF3 CCL5
10 viral infectious disease 29.8 OAS1 IRF3 CCR5 CCL5
11 human immunodeficiency virus type 1 29.8 IRF3 CCR5 CCL5
12 measles 29.5 OAS1 IRF3 CCL5
13 meningoencephalitis 10.9
14 japanese encephalitis 10.7
15 poliomyelitis 10.7
16 viral encephalitis 10.7
17 exanthem 10.7
18 guillain-barre syndrome 10.6
19 tremor 10.6
20 dengue virus 10.6
21 st. louis encephalitis 10.6
22 ataxia and polyneuropathy, adult-onset 10.5
23 chorioretinitis 10.5
24 myelitis 10.5
25 myocarditis 10.5
26 respiratory failure 10.4
27 vasculitis 10.4
28 myasthenia gravis 10.4
29 polyneuropathy 10.4
30 meningitis 10.4
31 myoclonus 10.4
32 autoimmune disease 10.3
33 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
34 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
35 quadriplegia 10.3
36 cytokine deficiency 10.3
37 meningitis and encephalitis 10.3
38 pars planitis 10.3
39 microvascular complications of diabetes 5 10.3
40 optic neuritis 10.3
41 aseptic meningitis 10.3
42 uveitis 10.3
43 neuromuscular disease 10.3
44 movement disease 10.3
45 47,xyy 10.3
46 stiff-person syndrome 10.2
47 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
48 murray valley encephalitis 10.2
49 choroiditis 10.2
50 retinal vasculitis 10.2

Graphical network of the top 20 diseases related to West Nile Virus Infection:



Diseases related to West Nile Virus Infection

Symptoms & Phenotypes for West Nile Virus Infection

Drugs & Therapeutics for West Nile Virus Infection

Drugs for West Nile Virus Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Rho(D) Immune Globulin Phase 2
2 gamma-Globulins Phase 2
3 Immunoglobulins, Intravenous Phase 2
4 Immunologic Factors Phase 2
5 Immunoglobulins Phase 2
6 Antibodies Phase 2
7 Antibodies, Monoclonal Phase 2
8 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Double Blind Placebo Controlled Trial to Assess the Safety and Efficacy of Intravenous Immunoglobulin (IVIG) in Children With Japanese Encephalitis in Nepal Completed NCT01856205 Phase 2 Intravenous immunoglobulin [ImmunoRelâ„¢ (batch 20081217)]
2 Phase 2, Stratified, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Safety and Efficacy of MGAWN1 in Subjects With Laboratory-documented West Nile Fever or Suspected Central Nervous System Infection Due to West Nile Virus Terminated NCT00927953 Phase 2
3 A Phase I Study of the Safety and Immunogenicity of a West Nile Virus Recombinant DNA Plasmid Vaccine, VRC-WNVDNA020-00-VP, in Healthy Adult Subjects Completed NCT00300417 Phase 1 VRC-WNVDNA020-00-VP
4 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00069303
5 Investigation of the Natural History of West Nile Virus Infection in Patients With Recently Acquired West Nile Fever or Neuroinvasive Disease Completed NCT00138463
6 Descriptive and Prognostic Study of Arbovirus Infections in France, Based on a Hospital Cohort of Children and Adults With Suspected Arbovirose.r Recruiting NCT01099852
7 Prospective Investigation of Oxidative Stress in West Nile Virus Infection Not yet recruiting NCT04371003
8 Expanded Access to MGAWN1 in Subjects With: Suspected West Nile Neuroinvasive Disease; Suspected West Nile Virus Infection and a Compromised Immune System; or Substantial Accidental Exposure to West Nile Virus No longer available NCT01206504

Search NIH Clinical Center for West Nile Virus Infection

Genetic Tests for West Nile Virus Infection

Anatomical Context for West Nile Virus Infection

MalaCards organs/tissues related to West Nile Virus Infection:

40
T Cells, Brain, Spinal Cord, Testes, B Cells, Bone Marrow, Bone

Publications for West Nile Virus Infection

Articles related to West Nile Virus Infection:

(show top 50) (show all 762)
# Title Authors PMID Year
1
Evidence of West Nile virus infection in migratory and resident wild birds in west coast of peninsular Malaysia. 61
32405525 2020
2
Personalized adapted locomotor training for an individual with sequelae of West Nile virus infection: a mixed-method case report. 61
30136877 2020
3
An unusual case of unilateral chorioretinitis and blind spot enlargement associated with asymptomatic West Nile virus infection. 61
32373759 2020
4
Delayed Diagnosis of West Nile Virus Infection in a Kidney Transplant Patient Due to Inaccuracies in Commonly Available Diagnostic Tests. 61
30602362 2020
5
Epidemic West Nile Virus Infection Rates and Endemic Population Dynamics Among South Dakota Mosquitoes: A 15-yr Study from the United States Northern Great Plains. 61
31799615 2020
6
Can local risk of West Nile virus infection be predicted from previous cases? A descriptive study in Quebec, 2011-2016. 61
32020540 2020
7
First serological evidence of West Nile virus infection in wild birds in Northern Algeria. 61
31945717 2020
8
Horizontal and Vertical Transmission of West Nile Virus by Aedes vexans (Diptera: Culicidae). 61
32188992 2020
9
Antibody-free rapid diagnosis of malaria in whole blood with surface-enhanced Raman Spectroscopy using Nanostructured Gold Substrate. 61
31923771 2020
10
Comparison of a human neuronal model proteome upon Japanese encephalitis or West Nile Virus infection and potential role of mosquito saliva in neuropathogenesis. 61
32374750 2020
11
Imported Human West Nile Virus Lineage 2 Infection in Spain: Neurological and Gastrointestinal Complications. 61
32013149 2020
12
Two case reports of neuroinvasive West Nile virus infection in the Almaty region, Kazakhstan. 61
32577401 2020
13
Comparative Pathology of West Nile Virus in Humans and Non-Human Animals. 61
31935992 2020
14
VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection. 61
31694946 2020
15
Cellular microRNA-155 Regulates Virus-Induced Inflammatory Response and Protects against Lethal West Nile Virus Infection. 61
31861621 2019
16
Cochlear-Vestibular Impairment due to West Nile Virus Infection. 61
31366220 2019
17
A Molecular Screening of Mosquitoes (Diptera: Culicidae) for Flaviviruses in a Focus of West Nile Virus Infection in Northern Iran. 61
32368556 2019
18
West Nile Virus Infection Blocks Inflammatory Response and T Cell Costimulatory Capacity of Human Monocyte-Derived Dendritic Cells. 61
31534040 2019
19
Microglia in Memory Decline from Zika Virus and West Nile Virus Infection. 61
31495452 2019
20
West Nile Virus infection triggering autoimmune encephalitis: Pathophysiological and therapeutic implications. 61
31454696 2019
21
Fatal West Nile Virus Infection in a Virginia Opossum (Didelphis virginiana) with Pulmonary Lepidic-Predominant Adenocarcinoma. 61
31008678 2019
22
Plasmodium vivax Malaria Presenting with Acute Systemic Capillary Leak Syndrome. 61
31571465 2019
23
WEST NILE VIRUS INFECTION WITH NEUROLOGICAL DISORDERS: A CASE REPORT AND A BRIEF REVIEW OF THE SITUATION IN BULGARIA. 61
31969770 2019
24
JC virus identified in a patient with persistent and severe West Nile virus disease. 61
30949974 2019
25
RIG-I-like receptors direct inflammatory macrophage polarization against West Nile virus infection. 61
31409781 2019
26
STING is required for host defense against neuropathological West Nile virus infection. 61
31415679 2019
27
Associations between the presence of specific antibodies to the West Nile Virus infection and candidate genes in Romanian horses from the Danube delta. 61
31175514 2019
28
Neuroinvasive West Nile Virus Disease in an Elderly Patient with Diffuse Large B-Cell Lymphoma Treated with R-CHOP Therapy: A Case Report 61
31218878 2019
29
Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis. 61
31273220 2019
30
Facial Diplegia in Neuroinvasive West Nile Virus Infection. 61
31060643 2019
31
Spectrum of Movement Disorders in Patients With Neuroinvasive West Nile Virus Infection. 61
31392241 2019
32
Genetic susceptibility to West Nile virus infection in Camargue horses. 61
31005660 2019
33
West Nile virus infection and interferon alpha treatment alter the spectrum and the levels of coding and noncoding host RNAs secreted in extracellular vesicles. 61
31182021 2019
34
West Nile virus infection in Brazil. 61
31166492 2019
35
West Nile virus infection in individuals with pre-existing Usutu virus immunity, northern Italy, 2018. 61
31138361 2019
36
Sex differences in cytokine production following West Nile virus infection: Implications for symptom manifestation. 61
30915442 2019
37
West Nile virus infection in horses in Saudi Arabia (in 2013-2015). 61
30402969 2019
38
Emergence of human West Nile Virus infection among pediatric population in Madhya Pradesh, India. 61
30257043 2019
39
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection. 61
30721061 2019
40
Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection. 61
30642926 2019
41
West Nile Virus Infection in Travelers Returning to United Kingdom from South Africa. 61
30666938 2019
42
Cumulative Incidence of West Nile Virus Infection, Continental United States, 1999-2016. 61
30666940 2019
43
Acute and Delayed Deaths after West Nile Virus Infection, Texas, USA, 2002-2012. 61
30667356 2019
44
IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection. 61
30457675 2019
45
Detection of West Nile Virus Infection in Viral Encephalitis Cases, China. 61
29985780 2019
46
AgBR1 antibodies delay lethal Aedes aegypti-borne West Nile virus infection in mice. 61
31312526 2019
47
A Recombinant Subviral Particle-Based Vaccine Protects Magpie (Pica pica) Against West Nile Virus Infection. 61
31231320 2019
48
Deletion of Pregnancy Zone Protein and Murinoglobulin-1 Restricts the Pathogenesis of West Nile Virus Infection in Mice. 61
30814992 2019
49
West Nile virus infection in Europe: need for an integration of occupational health practice and public health activities. Commentary. 61
30968829 2019
50
West Nile Virus infection in a renal transplant recipient resulting in polioencephalomylelitis, quadriplegia, and global brain atrophy. 61
31193054 2019

Variations for West Nile Virus Infection

Expression for West Nile Virus Infection

Search GEO for disease gene expression data for West Nile Virus Infection.

Pathways for West Nile Virus Infection

GO Terms for West Nile Virus Infection

Biological processes related to West Nile Virus Infection according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.65 IRF3 CCR5 ANPEP
2 immune response GO:0006955 9.61 OAS1 CCR5 CCL5
3 response to virus GO:0009615 9.49 OAS1 CCL5
4 cell chemotaxis GO:0060326 9.46 CCR5 CCL5
5 chemokine-mediated signaling pathway GO:0070098 9.4 CCR5 CCL5
6 interferon-gamma-mediated signaling pathway GO:0060333 9.37 OAS1 IRF3
7 type I interferon signaling pathway GO:0060337 9.32 OAS1 IRF3
8 negative regulation of viral genome replication GO:0045071 9.26 OAS1 CCL5
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.16 IRF3 CCL5
10 dendritic cell chemotaxis GO:0002407 8.96 CCR5 CCL5
11 negative regulation of macrophage apoptotic process GO:2000110 8.62 CCR5 CCL5

Molecular functions related to West Nile Virus Infection according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.26 IRF3 CCR5 CCL5 ATF6
2 virus receptor activity GO:0001618 9.16 CCR5 ANPEP
3 phosphatidylinositol phospholipase C activity GO:0004435 8.62 CCR5 CCL5

Sources for West Nile Virus Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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