WEE
MCID: WST002
MIFTS: 39

Western Equine Encephalitis (WEE)

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Western Equine Encephalitis

MalaCards integrated aliases for Western Equine Encephalitis:

Name: Western Equine Encephalitis 12 73 20 58 15 17 32
Encephalomyelitis, Western Equine 44 70
Western Equine Encephalomyelitis 20 58
Wee 12 20

Characteristics:

Orphanet epidemiological data:

58
western equine encephalitis
Inheritance: Not applicable; Prevalence: <1/1000000 (United States); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:10843
ICD9CM 34 062.1
MeSH 44 D020241
NCIt 50 C85227
SNOMED-CT 67 47523006
ICD10 32 A83.1
ICD10 via Orphanet 33 A83.1
UMLS via Orphanet 71 C0153064
Orphanet 58 ORPHA83593
UMLS 70 C0153064

Summaries for Western Equine Encephalitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Western equine encephalomyelitis virus, which is transmitted by Culex and transmitted by Aedes species of mosquitoes. The infection has symptom fever, has symptom headache, has symptom nausea, has symptom vomiting, has symptom anorexia, has symptom malaise, has symptom altered mental status, and has symptom weakness.

MalaCards based summary : Western Equine Encephalitis, also known as encephalomyelitis, western equine, is related to eastern equine encephalitis and encephalitis, and has symptoms including vomiting, fever and anorexia. An important gene associated with Western Equine Encephalitis is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are Cellular senescence (KEGG) and Cell cycle Cell cycle (generic schema). The drugs Vaccines and Aluminum hydroxide have been mentioned in the context of this disorder. Affiliated tissues include brain of horses, salivary gland and spleen.

Wikipedia : 73 The Western equine encephalomyelitis virus is the causative agent of relatively uncommon viral disease... more...

Related Diseases for Western Equine Encephalitis

Diseases related to Western Equine Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 eastern equine encephalitis 30.4 SH2D3C SH2D3A PRSS57 ERVW-1 ERF
2 encephalitis 11.2
3 venezuelan equine encephalitis 10.4
4 st. louis encephalitis 10.4
5 rabies 10.3
6 vaccinia 10.3
7 poliomyelitis 10.3
8 viral infectious disease 10.3
9 blue toe syndrome 10.2 SH2D3C SH2D3A
10 tenosynovitis 10.2 SH2D3A PRSS57
11 west nile virus 10.1
12 la crosse encephalitis 10.1
13 exanthem 10.1
14 japanese encephalitis 10.1
15 hydrocephalus 10.1
16 viral encephalitis 10.1
17 acute diarrhea 10.1 SH2D3A PRSS57
18 noonan syndrome 2 10.1 SH2D3C SH2D3A
19 beriberi 10.0
20 stomatitis 10.0
21 yellow fever 10.0
22 severe combined immunodeficiency with sensitivity to ionizing radiation 10.0 RAG1 H2AC18
23 triiodothyronine receptor auxiliary protein 10.0
24 immune deficiency disease 10.0
25 ocular motor apraxia 10.0
26 human immunodeficiency virus type 1 10.0
27 chikungunya 10.0
28 tick-borne encephalitis 10.0
29 sleep apnea 10.0
30 parkinsonism 10.0
31 sleeping sickness 10.0
32 mumps 10.0
33 meningoencephalitis 10.0
34 microcephaly 10.0
35 newcastle disease 10.0
36 myelitis 10.0
37 aortic aneurysm 10.0
38 myocarditis 10.0
39 herpes simplex 10.0
40 herpes simplex encephalitis 10.0
41 tremor 10.0
42 posttransplant acute limbic encephalitis 10.0
43 zika fever 10.0 SH2D3C ERVW-1
44 immunodeficiency with hyper-igm, type 2 9.8 RAG1 H2AC18
45 coronavirus infectious disease 9.8 SH2D3C SH2D3A H2AC18 ERVW-1

Graphical network of the top 20 diseases related to Western Equine Encephalitis:



Diseases related to Western Equine Encephalitis

Symptoms & Phenotypes for Western Equine Encephalitis

Symptoms:

12
  • vomiting
  • fever
  • anorexia
  • headache
  • nausea
  • weakness
  • malaise
  • altered mental status

Drugs & Therapeutics for Western Equine Encephalitis

Drugs for Western Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 2
2
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
3
Aluminum sulfate Approved Phase 1 10043-01-3
4 Gastrointestinal Agents Phase 1
5 Adjuvants, Immunologic Phase 1
6 Antacids Phase 1
7 Immunologic Factors Phase 1
8 Anti-Ulcer Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 2 Open-Label Safety and Immunogenicity Study of the Western Equine Encephalitis (WEE) Vaccine, Inactivated, Dried, TSI-GSD 210, Lot 3-1-92, in Healthy Adult Subjects at Risk of Exposure to Western Equine Encephalitis Virus Recruiting NCT02466750 Phase 2
2 Phase 1 Study to Evaluate the Safety and Immunogenicity of the Western Equine Encephalitis (WEE) Vaccine, Inactivated, TSI-GSD 210, Lot 3-1-92, In Healthy Adults Completed NCT01159561 Phase 1
3 A Phase 1 Open Label, Dose-Escalation Clinical Trial to Evaluate the Safety and Immunogenicity of a Trivalent Virus-Like Particle (VLP) Encephalitis Vaccine, VRC-WEVVLP073-00-VP, in Healthy Adults Completed NCT03879603 Phase 1

Search NIH Clinical Center for Western Equine Encephalitis

Cochrane evidence based reviews: encephalomyelitis, western equine

Genetic Tests for Western Equine Encephalitis

Anatomical Context for Western Equine Encephalitis

The Foundational Model of Anatomy Ontology organs/tissues related to Western Equine Encephalitis:

19
Brain Of Horses

MalaCards organs/tissues related to Western Equine Encephalitis:

40
Salivary Gland, Spleen, Brain, Skin, Kidney

Publications for Western Equine Encephalitis

Articles related to Western Equine Encephalitis:

(show top 50) (show all 709)
# Title Authors PMID Year
1
Impact of alphavirus 3'UTR plasticity on mosquito transmission. 61
32665176 2021
2
Beat the heat: Culex quinquefasciatus regulates its body temperature during blood feeding. 61
33627266 2021
3
A Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins. 61
33644063 2021
4
Stabilization of a Broadly Neutralizing Anti-Chikungunya Virus Single Domain Antibody. 61
33585527 2021
5
First Record of Mosquito-Borne Kyzylagach Virus in Central Europe. 61
33339099 2020
6
Serosurvey of Eastern, Western, and Venezuelan Equine Encephalitis Viruses in Wild Boars (Sus scrofa), Hunting Dogs, and Hunters of Brazil. 61
32644885 2020
7
Comparative pathology study of Venezuelan, eastern, and western equine encephalitis viruses in non-human primates. 61
32755661 2020
8
Transmission of West Nile and five other temperate mosquito-borne viruses peaks at temperatures between 23°C and 26°C. 61
32930091 2020
9
How virus size and attachment parameters affect the temperature sensitivity of virus binding to host cells: Predictions of a thermodynamic model for arboviruses and HIV. 61
32292808 2020
10
Vaccine Advances against Venezuelan, Eastern, and Western Equine Encephalitis Viruses. 61
32503232 2020
11
Mosquito Iridescent Virus: New Records from Nature and Infections Using Strelkovimermis spiculatus (Mermithidae) as a Vector Under Laboratory Conditions. 61
31903519 2020
12
"Submergence" of Western equine encephalitis virus: Evidence of positive selection argues against genetic drift and fitness reductions. 61
32027727 2020
13
Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry. 61
32047126 2020
14
A Monovalent and Trivalent MVA-Based Vaccine Completely Protects Mice Against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenge. 61
33542715 2020
15
The Capsid Protein of Semliki Forest Virus Antagonizes RNA Interference in Mammalian Cells. 61
31694940 2020
16
Immunopathogenesis of alphaviruses. 61
32711733 2020
17
SEROLOGICAL SURVEY FOR SELECT INFECTIOUS AGENTS IN WILD MAGELLANIC PENGUINS (SPHENISCUS MAGELLANICUS) IN ARGENTINA, 1994-2008. 61
31237822 2020
18
Agua Salud alphavirus defines a novel lineage of insect-specific alphaviruses discovered in the New World. 61
31674898 2020
19
Complete Coding Sequence of Western Equine Encephalitis Virus Strain Fleming, Isolated from a Human Case. 61
31896634 2020
20
The Western Equine Encephalitis Lyophilized, Inactivated Vaccine: An Update on Safety and Immunogenicity. 61
33240257 2020
21
The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection. 61
31494195 2019
22
Cooperativity between the 3' untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus. 61
31658290 2019
23
New World alphavirus protein interactomes from a therapeutic perspective. 61
30695702 2019
24
Continued Evidence of Decline in the Enzootic Activity of Western Equine Encephalitis Virus in Colorado. 61
30535264 2019
25
Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation. 61
31531390 2019
26
Selection of Single-Domain Antibodies towards Western Equine Encephalitis Virus. 61
31544894 2018
27
Repurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses. 61
29981794 2018
28
Serological evidence of widespread exposure of Grenada fruit bats to chikungunya virus. 61
29575672 2018
29
Genetic control of alphavirus pathogenesis. 61
30151711 2018
30
Genomic Characterization and Seroprevalence Studies on Alphaviruses in Uruguay. 61
29633690 2018
31
First Record of Aedes albifasciatus in Magallanes Region, Chile. 61
31442155 2018
32
Wing morphometrics of Aedes (Ochlerotatus) albifasciatus (Macquart, 1838) (Diptera: Culicidae) from different climatic regions of Argentina. 61
29769098 2018
33
Human-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus. 61
29587363 2018
34
Zoonotic Viral Diseases of Equines and Their Impact on Human and Animal Health. 61
30288197 2018
35
Broad-spectrum monoclonal antibodies against chikungunya virus structural proteins: Promising candidates for antibody-based rapid diagnostic test development. 61
30557365 2018
36
Host-Feeding Patterns of Culex stigmatosoma (Diptera: Culicidae) in Southern California. 61
28968822 2017
37
Potential Sympatric Vectors and Mammalian Hosts of Venezuelan Equine Encephalitis Virus in Southern Mexico. 61
28384059 2017
38
Susceptibility and Lethality of Western Equine Encephalitis Virus in Balb/c Mice When Infected by the Aerosol Route. 61
28654007 2017
39
Exploring genetic variation in haplotypes of the filariasis vector Culex quinquefasciatus (Diptera: Culicidae) through DNA barcoding. 61
28126462 2017
40
Ablation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity. 61
27852852 2017
41
The role of birds in arboviral disease surveillance in Harris County and the City of Houston, Texas. 61
28511269 2017
42
Discovery of a novel alphavirus related to Eilat virus. 61
28206905 2017
43
Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses. 61
27632563 2016
44
Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells. 61
27902702 2016
45
Notice to Readers: Final 2015 Reports of Nationally Notifiable Infectious Diseases and Conditions. 61
27880744 2016
46
Alphavirus protease inhibitors from natural sources: A homology modeling and molecular docking investigation. 61
27387412 2016
47
Virus-specific thermostability and heat inactivation profiles of alphaviruses. 61
27079828 2016
48
Culex Tarsalis Mosquitoes as Vectors of Highlands J Virus. 61
27248005 2016
49
Hospitalized Children With Encephalitis in the United States: A Pediatric Health Information System Database Study. 61
27353693 2016
50
Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection. 61
27053560 2016

Variations for Western Equine Encephalitis

Expression for Western Equine Encephalitis

Search GEO for disease gene expression data for Western Equine Encephalitis.

Pathways for Western Equine Encephalitis

Pathways related to Western Equine Encephalitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.63 LIN37 CDK1 CCNB3
2
Show member pathways
11.06 LIN37 CDK1 CCNB3
3
Show member pathways
10.45 WEE1 CDK1 CCNB3
4 10.43 CDK1 CCNB3

GO Terms for Western Equine Encephalitis

Biological processes related to Western Equine Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitotic cell cycle phase transition GO:0044772 8.62 CDK1 CCNB3

Sources for Western Equine Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....