MCID: WST002
MIFTS: 38

Western Equine Encephalitis

Categories: Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Western Equine Encephalitis

MalaCards integrated aliases for Western Equine Encephalitis:

Name: Western Equine Encephalitis 12 77 54 60 15 17
Encephalomyelitis, Western Equine 45 74
Western Equine Encephalomyelitis 54 60
Wee 12 54

Characteristics:

Orphanet epidemiological data:

60
western equine encephalitis
Inheritance: Not applicable; Prevalence: <1/1000000 (United States); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:10843
ICD9CM 36 062.1
MeSH 45 D020241
NCIt 51 C85227
SNOMED-CT 69 47523006
ICD10 34 A83.1
ICD10 via Orphanet 35 A83.1
UMLS via Orphanet 75 C0153064
Orphanet 60 ORPHA83593
UMLS 74 C0153064

Summaries for Western Equine Encephalitis

Disease Ontology : 12 A viral infectious disease that results in inflammation located in brain of horses and humans, has material basis in Western equine encephalomyelitis virus, which is transmitted by Culex and transmitted by Aedes species of mosquitoes. The infection has symptom fever, has symptom headache, has symptom nausea, has symptom vomiting, has symptom anorexia, has symptom malaise, has symptom altered mental status, and has symptom weakness.

MalaCards based summary : Western Equine Encephalitis, also known as encephalomyelitis, western equine, is related to encephalitis and eastern equine encephalitis, and has symptoms including fever, vomiting and anorexia. An important gene associated with Western Equine Encephalitis is KLHL41 (Kelch Like Family Member 41). The drugs Immunologic Factors and Vaccines have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related phenotype is growth/size/body region.

Wikipedia : 77 The Western equine encephalomyelitis virus is the causative agent of relatively uncommon viral disease... more...

Related Diseases for Western Equine Encephalitis

Diseases related to Western Equine Encephalitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 encephalitis 11.1
2 eastern equine encephalitis 10.3
3 st. louis encephalitis 10.1
4 poliomyelitis 10.1
5 tick-borne encephalitis 10.0
6 beriberi 10.0
7 human immunodeficiency virus type 1 10.0
8 sleep apnea 10.0
9 mumps 10.0
10 japanese encephalitis 10.0
11 rabies 10.0
12 myocarditis 10.0
13 influenza 10.0
14 herpes simplex 10.0
15 venezuelan equine encephalitis 10.0
16 herpes simplex encephalitis 10.0

Graphical network of the top 20 diseases related to Western Equine Encephalitis:



Diseases related to Western Equine Encephalitis

Symptoms & Phenotypes for Western Equine Encephalitis

Symptoms:

12
  • fever
  • vomiting
  • anorexia
  • headache
  • nausea
  • weakness
  • malaise
  • altered mental status

MGI Mouse Phenotypes related to Western Equine Encephalitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.1 CRY2 EDIL3 ERF FANCL KLHL41 TMPRSS15

Drugs & Therapeutics for Western Equine Encephalitis

Drugs for Western Equine Encephalitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2,Phase 1
2 Vaccines Phase 2,Phase 1
3
Aluminum sulfate Approved Phase 1 10043-01-3
4
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
5 Gastrointestinal Agents Phase 1
6 Anti-Ulcer Agents Phase 1
7 Antacids Phase 1
8 Adjuvants, Immunologic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Immunogenicity Study of the Western Equine Encephalitis (WEE) Vaccine Recruiting NCT02466750 Phase 2
2 Western Equine Encephalitis Vaccine, Inactivated Completed NCT01159561 Phase 1
3 VRC 313: A Trivalent Virus-like Particle (VLP) Encephalitis Vaccine (WEVEE) in Healthy Adults Recruiting NCT03879603 Phase 1

Search NIH Clinical Center for Western Equine Encephalitis

Cochrane evidence based reviews: encephalomyelitis, western equine

Genetic Tests for Western Equine Encephalitis

Anatomical Context for Western Equine Encephalitis

MalaCards organs/tissues related to Western Equine Encephalitis:

42
Brain, Testes, Skin, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Western Equine Encephalitis:

20
Brain Of Horses

Publications for Western Equine Encephalitis

Articles related to Western Equine Encephalitis:

(show top 50) (show all 200)
# Title Authors Year
1
Continued Evidence of Decline in the Enzootic Activity of Western Equine Encephalitis Virus in Colorado. ( 30535264 )
2019
2
Human-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus. ( 29587363 )
2018
3
Susceptibility and Lethality of Western Equine Encephalitis Virus in Balb/c Mice When Infected by the Aerosol Route. ( 28654007 )
2017
4
Surveillance for Western Equine Encephalitis, St. Louis Encephalitis, and West Nile Viruses Using Reverse Transcription Loop-Mediated Isothermal Amplification. ( 26807734 )
2016
5
Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection. ( 27053560 )
2016
6
Venezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses. ( 27632563 )
2016
7
Evolutionary genetics and vector adaptation of recombinant viruses of the western equine encephalitis antigenic complex provides new insights into alphavirus diversity and host switching. ( 25463613 )
2015
8
Manipulation of host factors optimizes the pathogenesis of western equine encephalitis virus infections in mice for antiviral drug development. ( 25361697 )
2015
9
Human-like antibodies neutralizing Western equine encephalitis virus. ( 24518197 )
2014
10
Novel indole-2-carboxamide compounds are potent broad-spectrum antivirals active against western equine encephalitis virus in vivo. ( 25031353 )
2014
11
Western equine encephalitis virus: evolutionary analysis of a declining alphavirus based on complete genome sequences. ( 24899192 )
2014
12
Molecular determinants of mouse neurovirulence and mosquito infection for Western equine encephalitis virus. ( 23544138 )
2013
13
Neurotropic arboviruses induce interferon regulatory factor 3-mediated neuronal responses that are cytoprotective, interferon independent, and inhibited by Western equine encephalitis virus capsid. ( 23192868 )
2013
14
Immune interference in the setting of same-day administration of two similar inactivated alphavirus vaccines: eastern equine and western equine encephalitis. ( 23031498 )
2012
15
Vector competence of five common mosquito species in the People's Republic of China for Western equine encephalitis virus. ( 22276651 )
2012
16
Evaluation of antiviral activity of aqueous extracts from Achyrocline satureioides against Western equine encephalitis virus. ( 20623427 )
2012
17
Factors affecting recombinant Western equine encephalitis virus glycoprotein production in the baculovirus system. ( 21864686 )
2011
18
Fatal human case of Western equine encephalitis, Uruguay. ( 21529429 )
2011
19
Envelope protein E1 as vaccine target for western equine encephalitis virus. ( 21084062 )
2011
20
Structure of the recombinant alphavirus Western equine encephalitis virus revealed by cryoelectron microscopy. ( 20631130 )
2010
21
Treatment with cationic liposome-DNA complexes (CLDCs) protects mice from lethal Western equine encephalitis virus (WEEV) challenge. ( 20452378 )
2010
22
Transmission potential of two chimeric western equine encephalitis vaccine candidates in Culex tarsalis. ( 20134017 )
2010
23
Identification of Western equine encephalitis virus structural proteins that confer protection after DNA vaccination. ( 19923571 )
2010
24
Chimeric alphavirus vaccine candidates protect mice from intranasal challenge with western equine encephalitis virus. ( 19446595 )
2009
25
Effect of T-705 treatment on western equine encephalitis in a mouse model. ( 19428608 )
2009
26
Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model. ( 19403754 )
2009
27
Western Equine Encephalitis submergence: lack of evidence for a decline in virus virulence. ( 18801549 )
2008
28
Cloning, expression and purification of envelope proteins E1 and E2 of western equine encephalitis virus and potential use of them as antigens in immunoassays. ( 18054449 )
2008
29
Maturation-dependent responses of human neuronal cells to western equine encephalitis virus infection and type I interferons. ( 18022665 )
2008
30
Functional pseudotyping of human immunodeficiency virus type 1 vectors by Western equine encephalitis virus envelope glycoprotein. ( 18842711 )
2008
31
Pre- and post-exposure protection against Western equine encephalitis virus after single inoculation with adenovirus vector expressing interferon alpha. ( 17761207 )
2007
32
Single-dose, fast-acting vaccine candidate against western equine encephalitis virus completely protects mice from intranasal challenge with different strains of the virus. ( 17630056 )
2007
33
Immunological evaluation of Escherichia coli expressed E2 protein of Western equine encephalitis virus. ( 17499379 )
2007
34
Complete protection of mice against a lethal dose challenge of western equine encephalitis virus after immunization with an adenovirus-vectored vaccine. ( 17467858 )
2007
35
Effect of exogenous interferon and an interferon inducer on western equine encephalitis virus disease in a hamster model. ( 17118420 )
2007
36
Infectivity variation and genetic diversity among strains of Western equine encephalitis virus. ( 16847131 )
2006
37
Aerosol exposure to western equine encephalitis virus causes fever and encephalitis in cynomolgus macaques. ( 16136459 )
2005
38
Efficacy of DNA vaccination against western equine encephalitis virus infection. ( 15755611 )
2005
39
Evaluation of a Western Equine Encephalitis recombinant E1 protein for protective immunity and diagnostics. ( 15498603 )
2004
40
Development of a biotin mimic tagged ScFv antibody against western equine encephalitis virus: bacterial expression and refolding. ( 15041214 )
2004
41
Sensitivity of the VecTest antigen assay for eastern equine encephalitis and western equine encephalitis viruses. ( 14710752 )
2003
42
Detection of antibodies to alphaviruses and discrimination between antibodies to eastern and western equine encephalitis viruses in rabbit sera using a recombinant antigen and virus-specific monoclonal antibodies. ( 14628996 )
2003
43
Limited potential for mosquito transmission of genetically engineered, live-attenuated western equine encephalitis virus vaccine candidates. ( 12641414 )
2003
44
Detection of North American eastern and western equine encephalitis viruses by nucleic acid amplification assays. ( 12517876 )
2003
45
Inhibition by Agaricus blazei Murill fractions of cytopathic effect induced by western equine encephalitis (WEE) virus on VERO cells in vitro. ( 11515550 )
2001
46
Pharmacokinetics study of a novel chimeric single-chain variable fragment antibody against western equine encephalitis virus. ( 11289221 )
2001
47
Construction and characterization of monoclonal antibodies against western equine encephalitis virus. ( 10868791 )
2000
48
Construction and characterization of a novel recombinant single-chain variable fragment antibody against Western equine encephalitis virus. ( 10768836 )
2000
49
Complete genomic RNA sequence of western equine encephalitis virus and expression of the structural genes. ( 10640553 )
2000
50
A single chain Fv specific against Western equine encephalitis virus. ( 10571261 )
1999

Variations for Western Equine Encephalitis

Expression for Western Equine Encephalitis

Search GEO for disease gene expression data for Western Equine Encephalitis.

Pathways for Western Equine Encephalitis

GO Terms for Western Equine Encephalitis

Biological processes related to Western Equine Encephalitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitotic cell cycle GO:0000278 8.62 ERF WEE2

Sources for Western Equine Encephalitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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