MCID: WTB001
MIFTS: 30

Wet Beriberi

Categories: Cardiovascular diseases, Metabolic diseases, Respiratory diseases

Aliases & Classifications for Wet Beriberi

MalaCards integrated aliases for Wet Beriberi:

Name: Wet Beriberi 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0070317
SNOMED-CT 67 67360000
ICD10 32 E51.12

Summaries for Wet Beriberi

Disease Ontology : 12 A beriberi that is located in the cardiovascular system and has symptom increased heart rate, swelling of lower legs, and shortness of breath.

MalaCards based summary : Wet Beriberi is related to dry beriberi and beriberi, and has symptoms including increased heart rate An important gene associated with Wet Beriberi is SLC35F3 (Solute Carrier Family 35 Member F3), and among its related pathways/superpathways is Vitamin digestion and absorption. The drugs Folic acid and Thiamine have been mentioned in the context of this disorder. Affiliated tissues include cardiovascular system, heart and endothelial, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 74 Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B1). A severe and chronic... more...

Related Diseases for Wet Beriberi

Graphical network of the top 20 diseases related to Wet Beriberi:



Diseases related to Wet Beriberi

Symptoms & Phenotypes for Wet Beriberi

Symptoms:

12
  • increased heart rate

GenomeRNAi Phenotypes related to Wet Beriberi according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-100 9.23 TOPORS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.23 SLC19A2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-113 9.23 TOPORS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-122 9.23 TOPORS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-176 9.23 HACL1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 9.23 TOPORS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-69 9.23 HACL1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.23 HACL1
9 Decreased cell–culture–derived Hepatitis C virus (HCVcc; Luc–Jc1) infection GR00234-A-2 9.16 BMX EPHA3
10 Decreased Hepatitis C Virus pseudoparticles (HCVpp; H77; genotype 1a) infection GR00234-A-1 8.96 BMX EPHA3

Drugs & Therapeutics for Wet Beriberi

Drugs for Wet Beriberi (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
2
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 2 59-43-8, 70-16-6 1130
3 Trace Elements Phase 2
4 Vitamins Phase 2
5 Vitamin B Complex Phase 2
6 Thiamin Phase 2
7 Nutrients Phase 2
8 Folate Phase 2
9 Vitamin B9 Phase 2
10 Micronutrients Phase 2
11 diuretics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effect of Thiamine vs. Placebo on VO2 in Critical Illness Completed NCT01985685 Phase 2 Thiamine
2 Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure on Long-term Treatment With Diuretic Drugs Completed NCT00770107 Thiamine;Placebo
3 The Effect of Thiamine on VO2 Levels in Critically Ill Patients Completed NCT01462279 Thiamine

Search NIH Clinical Center for Wet Beriberi

Genetic Tests for Wet Beriberi

Anatomical Context for Wet Beriberi

The Foundational Model of Anatomy Ontology organs/tissues related to Wet Beriberi:

19
Cardiovascular System

MalaCards organs/tissues related to Wet Beriberi:

40
Heart, Endothelial

Publications for Wet Beriberi

Articles related to Wet Beriberi:

(show all 42)
# Title Authors PMID Year
1
Wernicke's encephalopathy, refeeding syndrome and wet beriberi after laparoscopic sleeve gastrectomy: the importance of thiamine evaluation. 61
32047291 2020
2
A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. Moore (Fen Fang Ji). 61
32336965 2020
3
Role of Thiamin in Health and Disease. 61
30644592 2019
4
Dry Beriberi Due to Thiamine Deficiency Associated with Peripheral Neuropathy and Wernicke's Encephalopathy Mimicking Guillain-Barré syndrome: A Case Report and Review of the Literature. 61
30862772 2019
5
Beriberi disease in an 11-year-old girl with total colectomy. 61
30397502 2018
6
Thiamine and Cardiovascular Disease: A Literature Review. 61
29360523 2018
7
Wet beriberi with multiple organ failure remarkably reversed by thiamine administration: A case report and literature review. 61
29489643 2018
8
Wet Beriberi Associated with Hikikomori Syndrome. 61
29188542 2018
9
Case report: pericardial effusion with constrictive physiology in a patient with wet beriberi. 61
27059308 2016
10
High-Output Heart Failure Caused by Thyrotoxicosis and Beriberi. 61
26567494 2015
11
Wernicke's Encephalopathy, Wet Beriberi, and Polyneuropathy in a Patient with Folate and Thiamine Deficiency Related to Gastric Phytobezoar. 61
26697247 2015
12
[Thiamine deficiency in infants: a case report]. 61
24636593 2014
13
Shoshin beriberi induced by long-term administration of diuretics: a case report. 61
25105030 2014
14
Total parenteral nutrition caused Wernicke's encephalopathy accompanied by wet beriberi. 61
24516692 2014
15
"Dry" and "wet" beriberi mimicking critical illness polyneuropathy. 61
24339610 2013
16
Altered and unstable: wet beriberi, a clinical review. 61
23849362 2013
17
An eating disorder leading to wet beriberi heart failure in a 30-year-old woman. 61
23158607 2013
18
Increase of serum vascular endothelial growth factors in wet beriberi: two case reports. 61
22504253 2012
19
Cardiovascular magnetic resonance in wet beriberi. 61
21838901 2011
20
Outbreak of beriberi among African Union troops in Mogadishu, Somalia. 61
22205947 2011
21
A new crystal form of mouse thiamin pyrophosphokinase. 61
21552434 2011
22
Cardiac beriberi: often a missed diagnosis. 61
19934228 2010
23
Characteristics of thiamin and its relevance to the management of heart failure. 61
18849553 2008
24
Thiamin deficiency as a cause of reversible cor pulmonale. 61
18660937 2008
25
Loop diuretic therapy, thiamine balance, and heart failure. 61
17673878 2007
26
[A man with the combination of dry and wet beriberi]. 61
16808367 2006
27
Increased troponin I in "wet" beriberi. 61
16644891 2006
28
Pyrithiamine as a substrate for thiamine pyrophosphokinase. 61
16365036 2006
29
Thiamine deficiency and beriberi features in a patient with hyperemesis gravidarum. 61
15979284 2005
30
Gene-environment interactions in wet beriberi: effects of thiamine depletion in CD36-defect rats. 61
12969879 2003
31
Molecular mechanisms of thiamine utilization. 61
11899071 2001
32
[Cardiac beriberi]. 61
10816808 2000
33
Diuretic use: a risk for subclinical thiamine deficiency in elderly patients. 61
10842416 2000
34
Severe acidosis and hyperdynamic circulation in a 39-year-old alcoholic. 61
9696175 1998
35
Beriberi in a well-nourished Amazonian population. 61
9698265 1998
36
[Scurvy with simultaneous wet beriberi in 2 patients]. 61
7809869 1994
37
[A case of wet beriberi]. 61
2623323 1989
38
Carbonated drinks, thiamine deficiency and right ventricular failure. 61
3441782 1987
39
Chronic cardiac beriberi in a former prisoner of the Japanese. 61
7437412 1980
40
Wet beriberi in an alcoholic. 61
1139239 1975
41
John Blackall's observations on the relation between nutritional deprivation and wet beriberi. 61
13348836 1956
42
[Wet beriberi]. 61
13122862 1953

Variations for Wet Beriberi

Expression for Wet Beriberi

Search GEO for disease gene expression data for Wet Beriberi.

Pathways for Wet Beriberi

Pathways related to Wet Beriberi according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10 SLC19A3 SLC19A2

GO Terms for Wet Beriberi

Biological processes related to Wet Beriberi according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vitamin transport GO:0051180 9.32 SLC19A3 SLC19A2
2 vitamin transmembrane transport GO:0035461 9.26 SLC19A3 SLC19A2
3 thiamine-containing compound metabolic process GO:0042723 9.16 SLC19A3 SLC19A2
4 thiamine transmembrane transport GO:0071934 8.96 SLC19A3 SLC19A2
5 thiamine transport GO:0015888 8.8 SLC35F3 SLC19A3 SLC19A2

Molecular functions related to Wet Beriberi according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cofactor binding GO:0048037 9.26 TKT HACL1
2 thiamine pyrophosphate binding GO:0030976 9.16 TKT HACL1
3 vitamin transmembrane transporter activity GO:0090482 8.96 SLC19A3 SLC19A2
4 thiamine transmembrane transporter activity GO:0015234 8.62 SLC19A3 SLC19A2

Sources for Wet Beriberi

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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