MCID: WHT017
MIFTS: 31

Wheat Allergy

Categories: Immune diseases

Aliases & Classifications for Wheat Allergy

MalaCards integrated aliases for Wheat Allergy:

Name: Wheat Allergy 12 15
Wheat Hypersensitivity 44 73
Wheat Allergic Reaction 12
Allergy to Wheat 12
Allergy Wheat 55

Classifications:



External Ids:

Disease Ontology 12 DOID:3660
MeSH 44 D021182
UMLS 73 C0949570

Summaries for Wheat Allergy

MalaCards based summary : Wheat Allergy, also known as wheat hypersensitivity, is related to celiac disease 1 and food allergy. An important gene associated with Wheat Allergy is SCP2 (Sterol Carrier Protein 2), and among its related pathways/superpathways is PPAR signaling pathway. The drugs Barley and Micronutrients have been mentioned in the context of this disorder. Affiliated tissues include testes and skin, and related phenotype is homeostasis/metabolism.

Wikipedia : 76 Wheat allergy is an allergy to wheat which typically presents itself as a food allergy, but can also be... more...

Related Diseases for Wheat Allergy

Graphical network of the top 20 diseases related to Wheat Allergy:



Diseases related to Wheat Allergy

Symptoms & Phenotypes for Wheat Allergy

MGI Mouse Phenotypes related to Wheat Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.02 FABP2 SCP2 SLC25A3 TGM2 TOR1A

Drugs & Therapeutics for Wheat Allergy

Drugs for Wheat Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Barley Approved Not Applicable
2 Micronutrients
3 Trace Elements
4
Nickel 7440-02-0 934
5 Immunologic Factors
6 Antibodies, Antinuclear
7 Immunoglobulins
8 Antibodies
9 Caseins
10 Chelating Agents
11 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Oral Immunotherapy for Wheat Allergy Completed NCT01980992 Phase 1, Phase 2 Wheat OIT
2 Prevalence of Gluten Sensitivity in Irritable Bowel Syndrome: The First Study in Paediatrics. Unknown status NCT02431585 Not Applicable
3 Prevalence of Non Celiac Gluten Sensitivity Among Patients Spontaneously Adherent to Gluten Free Diet Unknown status NCT01827566 Not Applicable
4 Gluten Ingestion Biomarkers in Patients w Gluten Sensitivity and Healthy Controls Peptides in Patients With Non-celiac Gluten Sensitivity and Healthy Patients: A Placebo-controlled Study Unknown status NCT02936297 Not Applicable
5 Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study Completed NCT01070368 Not Applicable
6 The Natural History of Wheat Hypersensitivity in Thai Children Completed NCT01801748 Not Applicable
7 Oral Desensitization to Wheat in School Aged Children Completed NCT01755884 Not Applicable
8 Use of Hypoallergenic (H.A.) Cereals in Children With Diagnosed Allergy to Wheat Completed NCT01332084 Not Applicable
9 Major Allergen in Wheat Anaphylaxis in Thai Population Completed NCT03487315 Not Applicable
10 Abdominal Ultrasound Examination in Non-celiac Wheat Sensitivity Completed NCT03017274
11 Duodenal and Rectal Histology in Non-celiac Wheat Sensitivity and Irritable Bowel Syndrome Patients Completed NCT03022994
12 Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity Completed NCT02750735
13 Effects of Ancient Grains-based Diet in a Closed Community Completed NCT03020511 Not Applicable
14 Self-reported Gluten Sensitivity in High-school Students Completed NCT03021148
15 Non-Celiac Wheat Sensitivity: Permanent or Transient Condition? Completed NCT02823522
16 Non Coeliac Gluten Sensitivity in Children Completed NCT02895438 Not Applicable
17 Autoimmune Diseases And Serum Anti-Nuclear Antibodies Positivity In Non-Celiac Wheat Sensitivity Patients Completed NCT02248545
18 Bioelectrical Impedance Analysis of Not-celiac Wheat Sensitivity Patients Completed NCT01762566 Not Applicable
19 Gluten-free Oats and Gastrointestinal Health in Coeliac Disease, Part 2 Completed NCT02761785
20 Specific Oral Tolerance Induction (SOTI) to Children With IgE-mediated Wheat Allergy Recruiting NCT03352193
21 Gluten-related Disorders in Familial Mediterranean Fever Patients Recruiting NCT03563300 Not Applicable
22 Gynaecological Disorders in Not-celiac Wheat Sensitivity Recruiting NCT03027492 Not Applicable
23 Fibromyalgia-like Joint/Muscle Pain and Synovitis in Non-celiac Wheat Sensitivity Patients Recruiting NCT03022513 Not Applicable
24 Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients Recruiting NCT03008252
25 Response to Different Wheat Genotypes in Not-celiac Wheat Sensitivity Recruiting NCT03024775 Not Applicable
26 Diagnostic Significance of Positive EmA Antibodies in the Duodenal Culture Medium of Not-Celiac Wheat Sensitivity (NCWS) Recruiting NCT02203201
27 Bio-markers of Not-celiac Wheat Sensitivity Recruiting NCT01762579 Not Applicable
28 Changes in Intestinal Permeability 4 Hours After Gluten Challenge Recruiting NCT03288831 Not Applicable
29 The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk, and Nut Allergy in Adults Active, not recruiting NCT01822353 Not Applicable
30 Inflammatory Back Pain and Gluten Free Diet Not yet recruiting NCT03017716 Not Applicable
31 Food Challenge With Barley Starch as Active Comparator Suspended NCT03352856 Not Applicable
32 Evaluation of Potential Allergenicity of New Wheat Varieties Terminated NCT02341040

Search NIH Clinical Center for Wheat Allergy

Cochrane evidence based reviews: wheat hypersensitivity

Genetic Tests for Wheat Allergy

Anatomical Context for Wheat Allergy

MalaCards organs/tissues related to Wheat Allergy:

41
Testes, Skin

Publications for Wheat Allergy

Articles related to Wheat Allergy:

(show top 50) (show all 71)
# Title Authors Year
1
Celiac Disease and Wheat Allergy: A Growing Association? ( 29847816 )
2018
2
Predictors of Persistent Wheat Allergy in Children: A Retrospective Cohort Study. ( 29870996 )
2018
3
In extremis diagnosis of celiac disease and concomitant wheat allergy. ( 30249570 )
2018
4
Accuracy of in-house alcohol-dissolved wheat extract for diagnosing IgE-mediated wheat allergy. ( 30447656 )
2018
5
An Animal Model for Wheat Allergy Skin Sensitisation: A Comparative Study in Naive versus Tolerant Brown Norway Rats. ( 30517928 )
2018
6
Immunotherapy for IgE-mediated wheat allergy. ( 28895784 )
2017
7
Classification of cutaneous manifestations in patients with non-celiac gluten sensitivity (NCGS) and wheat allergy (WA). ( 29246823 )
2017
8
Antibody reactivity in patients with IgE-mediated wheat allergy to various subunits and fractions of gluten and non-gluten proteins from I8-gliadin-free wheat genotypes. ( 28664699 )
2017
9
Systematic review: Early infant feeding practices and the risk of wheat allergy. ( 28514046 )
2017
10
A three-level stepwise oral food challenge for egg, milk, and wheat allergy. ( 28847653 )
2017
11
Development of a prediction model for severe wheat allergy. ( 28892577 )
2017
12
What Do We Know Now about IgE-Mediated Wheat Allergy in Children? ( 28054973 )
2017
13
Wheat Allergy and Intolerence; Recent Updates and Perspectives. ( 24915366 )
2016
14
Celiac Disease, Wheat Allergy, and Non-Celiac Gluten Sensitivity: What's the Difference? ( 27363231 )
2016
15
Food IgG4 antibodies are elevated not only in children with wheat allergy but also in children with gastrointestinal diseases. ( 27004959 )
2016
16
Better management of wheat allergy using a very low-dose food challenge: A retrospective study. ( 26666490 )
2016
17
Age of Resolution from IgE-Mediated Wheat Allergy. ( 27543738 )
2016
18
Very low prevalence of IgE mediated wheat allergy and high levels of cross-sensitisation between grass and wheat in a UK birth cohort. ( 27335632 )
2016
19
Remission rate of patients with wheat allergy sensitized to hydrolyzed wheat protein in facial soap. ( 26666491 )
2016
20
Wheat allergy: diagnosis and management. ( 26889090 )
2016
21
Clinical presentation, allergens, and management of wheat allergy. ( 26800201 )
2016
22
THE COMPARISON OF EFFECTIVENESS OF SLOW SPECIFIC ORAL IMMUNOTHERAPY FOR WHEAT ALLERGY USING TWO DIFFERENT INTAKE FREQUENCY. ( 27616175 )
2016
23
Wheat allergy in celiac children. ( 26360318 )
2016
24
INCIDENCE OF APNEA ATTACK AS ALLERGIC REACTION AFTER ORAL FOOD CHALLENGE IN PATIENT WITH IgE-MEDIATED WHEAT ALLERGY. ( 27616176 )
2016
25
Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity. ( 26109797 )
2015
26
Current Trends and Investigative Developments in Wheat Allergy. ( 26241163 )
2015
27
Wheat allergy in a pediatric population from the Mediterranean area. ( 26177963 )
2015
28
Current trends and investigative developments in wheat allergy. ( 26288112 )
2015
29
Wheat allergy in children evaluated with challenge and IgE antibodies to wheat components. ( 25601168 )
2015
30
Eighteen cases of wheat allergy and wheat-dependent exercise-induced urticaria/anaphylaxis sensitized by hydrolyzed wheat protein in soap. ( 26096789 )
2015
31
IgE reactivity to carbohydrate moieties of glycoproteins in wheat allergy. ( 25976436 )
2015
32
Wheat allergy in children - new tools for diagnostics. ( 25146380 )
2014
33
Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap. ( 25040662 )
2014
34
A curious case of exercise-induced wheat allergy in adulthood. ( 24765886 )
2014
35
Oral immunotherapy in children with IgE-mediated wheat allergy: outcome and molecular changes. ( 25219106 )
2014
36
The natural history of IgE mediated wheat allergy in children with dominant gastrointestinal symptoms. ( 24572171 )
2014
37
A new reliable method for detecting specific IgE antibodies in the patients with immediate type wheat allergy due to hydrolyzed wheat protein: correlation of its titer and clinical severity. ( 24759554 )
2014
38
Chronic headaches and sleepiness caused by facial soap (containing hydrolyzed wheat proteins)-induced wheat allergy. ( 24429457 )
2014
39
Comparison of specific IgE antibodies to wheat component allergens in two phenotypes of wheat allergy. ( 24265539 )
2013
40
Patient-dependent differentiation of gluten protein IgE-binding epitopes in wheat allergy. ( 24720124 )
2013
41
Prevalence of wheat allergy in Al-Kharj, Saudi Arabia. ( 25098054 )
2013
42
Clinical utility of IgE antibodies to ω-5 gliadin in the diagnosis of wheat allergy: a pediatric multicenter challenge study. ( 22212744 )
2012
43
Celiac disease, wheat allergy, and gluten sensitivity: when gluten free is not a fad. ( 22237879 )
2012
44
Prevalence of wheat allergy in Japanese adults. ( 22377522 )
2012
45
Follow-up of the wheat allergy in children; consequences and outgrowing the allergy. ( 22761189 )
2012
46
The role of omega-5 gliadin-specific IgE test in diagnosing exercise-induced wheat allergy. ( 21109753 )
2011
47
Utility of the peripheral blood basophil histamine release test in the diagnosis of hen's egg, cow's milk, and wheat allergy in children. ( 21646803 )
2011
48
Usefulness of specific IgE antibodies to ω-5 gliadin in the diagnosis and follow-up of Japanese children with wheat allergy. ( 21962094 )
2011
49
The effect of wheat allergy on the course of atopic eczema in patients over 14 years of age. ( 22283110 )
2011
50
The prognosis of wheat hypersensitivity in children. ( 19793064 )
2010

Variations for Wheat Allergy

Expression for Wheat Allergy

Search GEO for disease gene expression data for Wheat Allergy.

Pathways for Wheat Allergy

Pathways related to Wheat Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.49 FABP2 SCP2

GO Terms for Wheat Allergy

Cellular components related to Wheat Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 8.92 FANCG SCP2 SLC25A3 TGM2

Molecular functions related to Wheat Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring acyl groups GO:0016746 8.62 SCP2 TGM2

Sources for Wheat Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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