MCID: WHT017
MIFTS: 30

Wheat Allergy

Categories: Immune diseases

Aliases & Classifications for Wheat Allergy

MalaCards integrated aliases for Wheat Allergy:

Name: Wheat Allergy 12 15
Wheat Allergic Reaction 12 17
Wheat Hypersensitivity 44 70
Allergy to Wheat 12
Allergy Wheat 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3660
MeSH 44 D021182
SNOMED-CT 67 420174000
UMLS 70 C0949570

Summaries for Wheat Allergy

Disease Ontology : 12 A food allergy that develops from exposure to and particularly consumption of wheat, and has symptom that are both gastrointestinal and nongastrointestinal in nature, such as diarrhea, mouth and throat irritation, headache, hives, skin rashes, and anaphylaxis.

MalaCards based summary : Wheat Allergy, also known as wheat allergic reaction, is related to gluten allergy and exercise-induced anaphylaxis. An important gene associated with Wheat Allergy is SCP2 (Sterol Carrier Protein 2). The drugs Pharmaceutical Solutions and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, and related phenotypes are homeostasis/metabolism and renal/urinary system

Wikipedia : 73 Wheat allergy is an allergy to wheat which typically presents itself as a food allergy, but can also be... more...

Related Diseases for Wheat Allergy

Diseases related to Wheat Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 gluten allergy 32.1 TOR1A TGM2
2 exercise-induced anaphylaxis 31.2 IGHE ENPP3
3 food allergy 30.6 TLR4 SCP2 IGHE ENPP3
4 peanut allergy 29.9 PDCL IGHE HLA-DQB1
5 celiac disease 1 29.7 TOR1A TLR4 TGM2 HP HLA-DQB1 FABP2
6 egg allergy 29.6 PDCL IGHE ENPP3 COPS7A
7 pollen allergy 29.0 SCP2 PDCL IGHE GHITM ENPP3
8 respiratory allergy 28.9 SCP2 PDCL IGHE GHITM ENPP3 COPS7A
9 cherry allergy 10.3 SCP2 IGHE
10 urticaria 10.3
11 amoxicillin allergy 10.3 IGHE ENPP3
12 occupational asthma 10.3 IGHE HLA-DQB1
13 dermatographia 10.3 IGHE ENPP3
14 torticollis 10.3 TOR1A SCP2
15 beta-lactam allergy 10.3 IGHE ENPP3
16 idiopathic nephrotic syndrome 10.3 IGHE HLA-DQB1
17 dermatitis, atopic 10.2
18 dermatitis 10.2
19 drug allergy 10.2 IGHE ENPP3
20 jejunoileitis 10.2 TOR1A TGM2
21 tropical sprue 10.2 TOR1A TGM2
22 torsion dystonia 2 10.2 TOR1A TGM2
23 shrimp allergy 10.2 HLA-DQB1 COPS7A
24 whipple disease 10.2 TOR1A TGM2
25 immunoglobulin a deficiency 1 10.2 TOR1A TGM2
26 refractory celiac disease 10.2 HLA-DQB1 FABP2
27 duodenitis 10.2 TOR1A TGM2
28 latex allergy 10.2 IGHE HLA-DQB1
29 lymphocytic colitis 10.2 TOR1A TGM2
30 torsion dystonia 4 10.2 TOR1A TGM2
31 dystonia 25 10.2 TOR1A TGM2
32 orange allergy 10.2 SCP2 PDCL
33 allergic bronchopulmonary aspergillosis 10.2 IGHE HLA-DQB1 ENPP3
34 giardiasis 10.2 TOR1A TGM2
35 fish allergy 10.1 PDCL IGHE
36 rhinitis 10.1
37 lactose intolerance 10.1 TOR1A TGM2
38 metal allergy 10.1 TLR4 HLA-DQB1
39 microscopic colitis 10.1 TOR1A TGM2 HLA-DQB1
40 cervical dystonia 10.1 TOR1A HLA-DQB1
41 corticosteroid allergy 10.1 PDCL COPS7A
42 tomato allergy 10.1 PDCL COPS7A
43 vulvar benign neoplasm 10.1 TOR1A HP
44 urinary schistosomiasis 10.1 IGHE HP
45 type 1 diabetes mellitus 2 10.1 TOR1A HLA-DQB1
46 melon allergy 10.1 PDCL COPS7A
47 apple allergy 10.1 SCP2 PDCL HLA-DQB1
48 alveolar echinococcosis 10.0 TLR4 HLA-DQB1
49 immunoglobulin e concentration, serum 10.0
50 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0

Graphical network of the top 20 diseases related to Wheat Allergy:



Diseases related to Wheat Allergy

Symptoms & Phenotypes for Wheat Allergy

MGI Mouse Phenotypes related to Wheat Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.65 COPS7A FABP2 HLA-DQB1 HP PDCL RBFOX1
2 renal/urinary system MP:0005367 9.1 COPS7A FABP2 HLA-DQB1 HP TGM2 TLR4

Drugs & Therapeutics for Wheat Allergy

Drugs for Wheat Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions
2 Immunoglobulins
3 Immunoglobulins, Intravenous
4 Immunoglobulin E
5 Antibodies

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Oral Immunotherapy for Wheat Allergy Completed NCT01980992 Phase 1, Phase 2 Wheat OIT
2 The Natural History of Wheat Hypersensitivity in Thai Children Completed NCT01801748
3 Prevalence of Self-reported Non-celiac Wheat Sensitivity (NCWS) in Patients Undergoing Digestive Endoscopy Completed NCT04154137
4 Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study Completed NCT01070368
5 Major Allergen in Wheat Anaphylaxis in Thai Population Completed NCT03487315
6 Oral Desensitization to Wheat in Children Over 6 Years of Age With Wheat Allergy Completed NCT01755884
7 Assessment of the Feasibility of a SOTI With Hypoallergenic (H.A.) Cereals in Children With Diagnosed IgE-mediated Allergy to Wheat Completed NCT01332084
8 The Innate Response to and Changes in Intestinal Permeability 4 Hours After a Gluten Challenge in Subjects With Celiac Disease and Non Celiac Gluten Sensitivity Completed NCT03288831
9 Specific Oral Tolerance Induction (SOTI) to Children With IgE-mediated Wheat Allergy Recruiting NCT03352193
10 Luminex-based Assay to Identify Major IgE-binding Episode Among IgE-mediated Wheat-allergic Patient Enrolling by invitation NCT04100122
11 Evaluation of Potential Allergenicity of New Wheat Varieties Terminated NCT02341040
12 Outcome of Specific IgE Level in Children With IgE-mediated Wheat Allergy After Stop Using Wheat Containing Skin Care Terminated NCT04013763

Search NIH Clinical Center for Wheat Allergy

Cochrane evidence based reviews: wheat hypersensitivity

Genetic Tests for Wheat Allergy

Anatomical Context for Wheat Allergy

MalaCards organs/tissues related to Wheat Allergy:

40
Skin

Publications for Wheat Allergy

Articles related to Wheat Allergy:

(show top 50) (show all 359)
# Title Authors PMID Year
1
The natural history of wheat allergy. 61 54
19492663 2009
2
IgE antibodies to omega-5 gliadin associate with immediate symptoms on oral wheat challenge in Japanese children. 54 61
18925890 2008
3
A novel wheat gliadin as a cause of exercise-induced anaphylaxis. 61 54
10329828 1999
4
Wheat alpha-amylase inhibitor: a second route of allergic sensitization. 54 61
9042052 1997
5
Immunologic cross-reactivity among cereal grains and grasses in children with food hypersensitivity. 54 61
7560636 1995
6
[Effect of hypoallergenic wheat (HAW-A1) on atopic dermatitis (AD) with wheat allergy, and its antigenic analysis using sera from patients with AD]. 54 61
8067902 1994
7
Extraction of total wheat (Triticum aestivum) protein fractions and cross-reactivity of wheat allergens with other cereals. 61
33486358 2021
8
Identification of peroxidase-1 and beta-glucosidase as cross-reactive wheat allergens in grass pollen-related wheat allergy. 61
33616048 2021
9
Treatment-requiring accidental ingestion and risk factors among nursery children with food allergy. 61
33748998 2021
10
All Things Gluten: A Review. 61
33518167 2021
11
Characterization of 150 Wheat Cultivars by LC-MS-Based Label-Free Quantitative Proteomics Unravels Possibilities to Design Wheat Better for Baking Quality and Human Health. 61
33668233 2021
12
Prevalence of Wheat/Gluten-Related Disorders and Gluten-Free Diet in Paraguay: An Online Survey-Based Study. 61
33513886 2021
13
The Gluten Gene: Unlocking the Understanding of Gluten Sensitivity and Intolerance. 61
33603437 2021
14
Symptoms of gluten ingestion in patients with non-celiac gluten sensitivity: A randomized clinical trial. 61
33053456 2021
15
Non-celiac wheat sensitivity: rationality and irrationality of a gluten-free diet in individuals affected with non-celiac disease: a review. 61
33407153 2021
16
Assessment of Immune Responses in an Animal Model of Wheat Food Allergy via Epicutaneous Sensitization. 61
33226585 2021
17
Profiling serum antibodies with a pan allergen phage library identifies key wheat allergy epitopes. 61
33483508 2021
18
Temporary wheat allergy in the postpartum period. 61
32565176 2021
19
Exercise-food challenge test in patients with wheat-dependent exercise-induced anaphylaxis. 61
33386792 2021
20
Current applications of gluten-free grains - a review. 61
31965815 2021
21
Celiac Disease and Sensitization to Wheat, Rye, and Barley: Should We Be Concerned? 61
33321512 2020
22
Is Gluten the Only Culprit for Non-Celiac Gluten/Wheat Sensitivity? 61
33321805 2020
23
Serum zonulin and its diagnostic performance in non-coeliac gluten sensitivity. 61
32060130 2020
24
Localized abdominal urticaria: A distinct clinical phenotype of wheat allergy in young children. 61
32569753 2020
25
Clinical and in vitro cross-reactivity of cereal grains in children with IgE-mediated wheat allergy. 61
32327208 2020
26
Feasibility of a 3-step protocol of wheat oral immunotherapy in children with severe wheat allergy. 61
33178563 2020
27
Noncoeliac wheat sensitivity and diet. 61
32452869 2020
28
Wheat-induced food allergy in childhood: ancient grains seem no way out. 61
31654113 2020
29
Pilot study on non-celiac gluten sensitivity: effects of Bifidobacterium longum ES1 co-administered with a gluten-free diet. 61
32397695 2020
30
Autoimmunity Features in Patients With Non-Celiac Wheat Sensitivity. 61
33009065 2020
31
Nonceliac Gluten and Wheat Sensitivity. 61
30978535 2020
32
An updated overview of spectrum of gluten-related disorders: clinical and diagnostic aspects. 61
32762724 2020
33
Comparative Characterization of Gluten and Hydrolyzed Wheat Proteins. 61
32846879 2020
34
Validation and Reliability of the Thai version of the Food Allergy Quality of Life Questionnaire-Parent Form (FAQLQ-PF). 61
32828118 2020
35
Accuracy of in-house alcohol-dissolved wheat extract for diagnosing IgE-mediated wheat allergy. 61
30447656 2020
36
Pitfalls in the Diagnosis of Coeliac Disease and Gluten-Related Disorders. 61
32517378 2020
37
Exercise-induced allergic reactions on desensitization to wheat after rush oral immunotherapy. 61
31953936 2020
38
Mechanisms of Wheat Allergenicity in Mice: Comparison of Adjuvant-Free vs. Alum-Adjuvant Models. 61
32369940 2020
39
A potential role of gliadin extract skin prick test in IgE-mediated wheat allergy. 61
32416667 2020
40
Prevalence of Adverse Reactions to Gluten and People Going on a Gluten-Free Diet: A Survey Study Conducted in Brazil. 61
32260408 2020
41
Characterization of children with IgE-mediated wheat allergy and risk factors that predict wheat anaphylaxis. 61
32247307 2020
42
Long-term dynamics of omega-5 gliadin-specific IgE levels in patients with adult-onset wheat allergy. 61
31678299 2020
43
Prevalence of Non-Celiac Gluten Sensitivity in Patients with Refractory Functional Dyspepsia: a Randomized Double-blind Placebo Controlled Trial. 61
32051513 2020
44
[Non-celiac Gluten Sensitivity]. 61
31986568 2020
45
The Two Faces of Wheat. 61
33195360 2020
46
Celiac Disease and Non-celiac Wheat Sensitivity: State of Art of Non-dietary Therapies. 61
33015123 2020
47
Pathogenesis of Celiac Disease and Other Gluten Related Disorders in Wheat and Strategies for Mitigating Them. 61
32118025 2020
48
Gluten-related disorders: Celiac disease, wheat allergy, and nonceliac gluten sensitivity. 61
31402697 2020
49
Celiac Disease. 61
31905394 2020
50
The potentials of probiotics on gluten hydrolysis; a review study. 61
33584998 2020

Variations for Wheat Allergy

Expression for Wheat Allergy

Search GEO for disease gene expression data for Wheat Allergy.

Pathways for Wheat Allergy

GO Terms for Wheat Allergy

Cellular components related to Wheat Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intrinsic component of plasma membrane GO:0031226 8.62 TLR4 TGM2

Biological processes related to Wheat Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein deneddylation GO:0000338 8.62 TOR1A COPS7A

Sources for Wheat Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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