MCID: WHT017
MIFTS: 34

Wheat Allergy

Categories: Immune diseases

Aliases & Classifications for Wheat Allergy

MalaCards integrated aliases for Wheat Allergy:

Name: Wheat Allergy 12 15
Wheat Allergic Reaction 12 17
Wheat Hypersensitivity 45 74
Allergy to Wheat 12
Allergy Wheat 56

Classifications:



External Ids:

Disease Ontology 12 DOID:3660
MeSH 45 D021182
UMLS 74 C0949570

Summaries for Wheat Allergy

Disease Ontology : 12 A food allergy that develops_from exposure to and particularly consumption of wheat, and has symptom that are both gastrointestinal and nongastrointestinal in nature, such as diarrhea, mouth and throat irritation, headache, hives, skin rashes, and anaphylaxis.

MalaCards based summary : Wheat Allergy, also known as wheat allergic reaction, is related to celiac disease 1 and gluten allergy. An important gene associated with Wheat Allergy is SCP2 (Sterol Carrier Protein 2), and among its related pathways/superpathways are DNA Damage Response (only ATM dependent) and PPAR signaling pathway. The drugs Barley and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin and testes, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 77 Wheat allergy is an allergy to wheat which typically presents itself as a food allergy, but can also be... more...

Related Diseases for Wheat Allergy

Diseases related to Wheat Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 celiac disease 1 30.2 TGM2 TOR1A
2 gluten allergy 11.2
3 food allergy 10.4
4 dermatitis 10.2
5 dermatitis, atopic 10.1
6 torticollis 10.0 SCP2 TOR1A
7 asthma 9.9
8 allergic hypersensitivity disease 9.9
9 urticaria 9.9
10 gastrointestinal system disease 9.9
11 exercise-induced anaphylaxis 9.9
12 autoimmune disease of skin and connective tissue 9.9 TGM2 TOR1A
13 immunoglobulin alpha deficiency 9.9 TGM2 TOR1A
14 autoimmune disease of gastrointestinal tract 9.8 TGM2 TOR1A
15 immune system disease 9.7 TGM2 TOR1A
16 extratemporal epilepsy 9.6 TGM2 TOR1A WNT10A

Graphical network of the top 20 diseases related to Wheat Allergy:



Diseases related to Wheat Allergy

Symptoms & Phenotypes for Wheat Allergy

MGI Mouse Phenotypes related to Wheat Allergy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.35 FABP2 SCP2 TGM2 TOR1A WNT10A
2 homeostasis/metabolism MP:0005376 9.02 FABP2 SCP2 SLC25A3 TGM2 TOR1A

Drugs & Therapeutics for Wheat Allergy

Drugs for Wheat Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Barley Approved Not Applicable
2 Immunologic Factors Not Applicable
3 Micronutrients
4
Nickel 7440-02-0 934
5 Nutrients
6 Trace Elements
7 Immunoglobulins
8 Antibodies
9 Antibodies, Antinuclear
10 Chelating Agents
11 Caseins
12 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Oral Immunotherapy for Wheat Allergy Completed NCT01980992 Phase 1, Phase 2 Wheat OIT
2 Prevalence of Gluten Sensitivity in Irritable Bowel Syndrome: The First Study in Paediatrics. Unknown status NCT02431585 Not Applicable
3 Prevalence of Non Celiac Gluten Sensitivity Among Patients Spontaneously Adherent to Gluten Free Diet Unknown status NCT01827566 Not Applicable
4 Gluten Ingestion Biomarkers in Patients w Gluten Sensitivity and Healthy Controls Peptides in Patients With Non-celiac Gluten Sensitivity and Healthy Patients: A Placebo-controlled Study Unknown status NCT02936297 Not Applicable
5 Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study Completed NCT01070368 Not Applicable
6 The Natural History of Wheat Hypersensitivity in Thai Children Completed NCT01801748 Not Applicable
7 Oral Desensitization to Wheat in School Aged Children Completed NCT01755884 Not Applicable
8 Use of Hypoallergenic (H.A.) Cereals in Children With Diagnosed Allergy to Wheat Completed NCT01332084 Not Applicable
9 Major Allergen in Wheat Anaphylaxis in Thai Population Completed NCT03487315 Not Applicable
10 Abdominal Ultrasound Examination in Non-celiac Wheat Sensitivity Completed NCT03017274
11 Duodenal and Rectal Histology in Non-celiac Wheat Sensitivity and Irritable Bowel Syndrome Patients Completed NCT03022994
12 Nickel Allergy and Systemic Nickel Allergy Syndrome in Non Celiac Wheat Sensitivity Completed NCT02750735
13 Effects of Ancient Grains-based Diet in a Closed Community Completed NCT03020511 Not Applicable
14 Self-reported Gluten Sensitivity in High-school Students Completed NCT03021148
15 Non-Celiac Wheat Sensitivity: Permanent or Transient Condition? Completed NCT02823522
16 Non Coeliac Gluten Sensitivity in Children Completed NCT02895438 Not Applicable
17 Autoimmune Diseases And Serum Anti-Nuclear Antibodies Positivity In Non-Celiac Wheat Sensitivity Patients Completed NCT02248545
18 Bioelectrical Impedance Analysis of Not-celiac Wheat Sensitivity Patients Completed NCT01762566 Not Applicable
19 Gluten-free Oats and Gastrointestinal Health in Coeliac Disease, Part 2 Completed NCT02761785
20 Specific Oral Tolerance Induction (SOTI) to Children With IgE-mediated Wheat Allergy Recruiting NCT03352193
21 Gluten-related Disorders in Familial Mediterranean Fever Patients Recruiting NCT03563300 Not Applicable
22 Gynaecological Disorders in Not-celiac Wheat Sensitivity Recruiting NCT03027492 Not Applicable
23 Fibromyalgia-like Joint/Muscle Pain and Synovitis in Non-celiac Wheat Sensitivity Patients Recruiting NCT03022513 Not Applicable
24 Lactose Intolerance and Cow's Milk Protein Allergy in Non-celiac Wheat Sensitivity Patients Recruiting NCT03008252
25 Response to Different Wheat Genotypes in Not-celiac Wheat Sensitivity Recruiting NCT03024775 Not Applicable
26 Diagnostic Significance of Positive EmA Antibodies in the Duodenal Culture Medium of Not-Celiac Wheat Sensitivity (NCWS) Recruiting NCT02203201
27 Bio-markers of Not-celiac Wheat Sensitivity Recruiting NCT01762579 Not Applicable
28 The Effect of Per Oral Immunotherapy in Severe IgE Mediated Egg, Milk, and Nut Allergy in Adults Active, not recruiting NCT01822353 Not Applicable
29 Changes in Intestinal Permeability 4 Hours After Gluten Challenge Enrolling by invitation NCT03288831 Not Applicable
30 Inflammatory Back Pain and Gluten Free Diet Not yet recruiting NCT03017716 Not Applicable
31 Food Challenge With Barley Starch as Active Comparator Suspended NCT03352856 Not Applicable
32 Evaluation of Potential Allergenicity of New Wheat Varieties Terminated NCT02341040

Search NIH Clinical Center for Wheat Allergy

Cochrane evidence based reviews: wheat hypersensitivity

Genetic Tests for Wheat Allergy

Anatomical Context for Wheat Allergy

MalaCards organs/tissues related to Wheat Allergy:

42
Skin, Testes

Publications for Wheat Allergy

Articles related to Wheat Allergy:

(show top 50) (show all 69)
# Title Authors Year
1
Identifying True Celiac Disease and Wheat Allergy in the Era of Fashion Driven Gluten-Free Diets. ( 30897589 )
2019
2
Celiac Disease and Wheat Allergy: A Growing Association? ( 29847816 )
2018
3
Predictors of Persistent Wheat Allergy in Children: A Retrospective Cohort Study. ( 29870996 )
2018
4
In extremis diagnosis of celiac disease and concomitant wheat allergy. ( 30249570 )
2018
5
Accuracy of in-house alcohol-dissolved wheat extract for diagnosing IgE-mediated wheat allergy. ( 30447656 )
2018
6
An Animal Model for Wheat Allergy Skin Sensitisation: A Comparative Study in Naive versus Tolerant Brown Norway Rats. ( 30517928 )
2018
7
Immunotherapy for IgE-mediated wheat allergy. ( 28895784 )
2017
8
Classification of cutaneous manifestations in patients with non-celiac gluten sensitivity (NCGS) and wheat allergy (WA). ( 29246823 )
2017
9
Antibody reactivity in patients with IgE-mediated wheat allergy to various subunits and fractions of gluten and non-gluten proteins from I8-gliadin-free wheat genotypes. ( 28664699 )
2017
10
Systematic review: Early infant feeding practices and the risk of wheat allergy. ( 28514046 )
2017
11
A three-level stepwise oral food challenge for egg, milk, and wheat allergy. ( 28847653 )
2017
12
Development of a prediction model for severe wheat allergy. ( 28892577 )
2017
13
What Do We Know Now about IgE-Mediated Wheat Allergy in Children? ( 28054973 )
2017
14
Wheat Allergy and Intolerence; Recent Updates and Perspectives. ( 24915366 )
2016
15
Celiac Disease, Wheat Allergy, and Non-Celiac Gluten Sensitivity: What's the Difference? ( 27363231 )
2016
16
Food IgG4 antibodies are elevated not only in children with wheat allergy but also in children with gastrointestinal diseases. ( 27004959 )
2016
17
Better management of wheat allergy using a very low-dose food challenge: A retrospective study. ( 26666490 )
2016
18
Age of Resolution from IgE-Mediated Wheat Allergy. ( 27543738 )
2016
19
Very low prevalence of IgE mediated wheat allergy and high levels of cross-sensitisation between grass and wheat in a UK birth cohort. ( 27335632 )
2016
20
Remission rate of patients with wheat allergy sensitized to hydrolyzed wheat protein in facial soap. ( 26666491 )
2016
21
Wheat allergy: diagnosis and management. ( 26889090 )
2016
22
Clinical presentation, allergens, and management of wheat allergy. ( 26800201 )
2016
23
THE COMPARISON OF EFFECTIVENESS OF SLOW SPECIFIC ORAL IMMUNOTHERAPY FOR WHEAT ALLERGY USING TWO DIFFERENT INTAKE FREQUENCY. ( 27616175 )
2016
24
Wheat allergy in celiac children. ( 26360318 )
2016
25
INCIDENCE OF APNEA ATTACK AS ALLERGIC REACTION AFTER ORAL FOOD CHALLENGE IN PATIENT WITH IgE-MEDIATED WHEAT ALLERGY. ( 27616176 )
2016
26
Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity. ( 26109797 )
2015
27
Current Trends and Investigative Developments in Wheat Allergy. ( 26241163 )
2015
28
Wheat allergy in a pediatric population from the Mediterranean area. ( 26177963 )
2015
29
Current trends and investigative developments in wheat allergy. ( 26288112 )
2015
30
Wheat allergy in children evaluated with challenge and IgE antibodies to wheat components. ( 25601168 )
2015
31
Eighteen cases of wheat allergy and wheat-dependent exercise-induced urticaria/anaphylaxis sensitized by hydrolyzed wheat protein in soap. ( 26096789 )
2015
32
IgE reactivity to carbohydrate moieties of glycoproteins in wheat allergy. ( 25976436 )
2015
33
Wheat allergy in children - new tools for diagnostics. ( 25146380 )
2014
34
Epidemiological link between wheat allergy and exposure to hydrolyzed wheat protein in facial soap. ( 25040662 )
2014
35
A curious case of exercise-induced wheat allergy in adulthood. ( 24765886 )
2014
36
Oral immunotherapy in children with IgE-mediated wheat allergy: outcome and molecular changes. ( 25219106 )
2014
37
The natural history of IgE mediated wheat allergy in children with dominant gastrointestinal symptoms. ( 24572171 )
2014
38
A new reliable method for detecting specific IgE antibodies in the patients with immediate type wheat allergy due to hydrolyzed wheat protein: correlation of its titer and clinical severity. ( 24759554 )
2014
39
Chronic headaches and sleepiness caused by facial soap (containing hydrolyzed wheat proteins)-induced wheat allergy. ( 24429457 )
2014
40
Comparison of specific IgE antibodies to wheat component allergens in two phenotypes of wheat allergy. ( 24265539 )
2013
41
Patient-dependent differentiation of gluten protein IgE-binding epitopes in wheat allergy. ( 24720124 )
2013
42
Prevalence of wheat allergy in Al-Kharj, Saudi Arabia. ( 25098054 )
2013
43
Clinical utility of IgE antibodies to ω-5 gliadin in the diagnosis of wheat allergy: a pediatric multicenter challenge study. ( 22212744 )
2012
44
Celiac disease, wheat allergy, and gluten sensitivity: when gluten free is not a fad. ( 22237879 )
2012
45
Prevalence of wheat allergy in Japanese adults. ( 22377522 )
2012
46
Follow-up of the wheat allergy in children; consequences and outgrowing the allergy. ( 22761189 )
2012
47
The role of omega-5 gliadin-specific IgE test in diagnosing exercise-induced wheat allergy. ( 21109753 )
2011
48
Utility of the peripheral blood basophil histamine release test in the diagnosis of hen's egg, cow's milk, and wheat allergy in children. ( 21646803 )
2011
49
Usefulness of specific IgE antibodies to ω-5 gliadin in the diagnosis and follow-up of Japanese children with wheat allergy. ( 21962094 )
2011
50
The effect of wheat allergy on the course of atopic eczema in patients over 14 years of age. ( 22283110 )
2011

Variations for Wheat Allergy

Expression for Wheat Allergy

Search GEO for disease gene expression data for Wheat Allergy.

Pathways for Wheat Allergy

Pathways related to Wheat Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 SCP2 WNT10A
2 10.49 FABP2 SCP2

GO Terms for Wheat Allergy

Biological processes related to Wheat Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homooligomerization GO:0051260 8.62 TGM2 TOR1A

Molecular functions related to Wheat Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring acyl groups GO:0016746 8.62 SCP2 TGM2

Sources for Wheat Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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