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MCID: WHP002
MIFTS: 35

Whiplash

Categories: Muscle diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Whiplash

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MalaCards integrated aliases for Whiplash:

Name: Whiplash 53

Classifications:

MalaCards categories:
Anatomical: Muscle diseases
See all MalaCards categories (disease lists)


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Summaries for Whiplash

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NINDS : 53 Whiplash-a soft tissue injury to the neck-is also called neck sprain or neck strain. It is characterized by a collection of symptoms that occur following damage to the neck, usually because of sudden extension and flexion. The disorder commonly occurs as the result of an automobile accident and may include injury to intervertebral joints, discs, and ligaments, cervical muscles, and nerve roots. Symptoms such as neck pain may be present directly after the injury or may be delayed for several days. In addition to neck pain, other symptoms may include neck stiffness, injuries to the muscles and ligaments (myofascial injuries), headache, dizziness, abnormal sensations such as burning or prickling (paresthesias), or shoulder or back pain. In addition, some people experience cognitive, somatic, or psychological conditions such as memory loss, concentration impairment, nervousness/irritability, sleep disturbances, fatigue, or depression.

MalaCards based summary : Whiplash is related to radiculopathy and paine syndrome. An important gene associated with Whiplash is CCL3 (C-C Motif Chemokine Ligand 3), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drugs Hydrocortisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include eye, spinal cord and brain.

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Related Diseases for Whiplash

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Diseases related to Whiplash via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 radiculopathy 30.3 CCL5 CCL4 CCL3
2 paine syndrome 29.7 KNG1 COMT
3 pain agnosia 29.7 KNG1 COMT
4 disease by infectious agent 29.5 CCR5 CCL4 CCL3
5 multiple sclerosis 28.7 IL16 CCR5 CCL5 CCL4 CCL3
6 disease of mental health 28.1 KNG1 COMT CCR5 CCL5 CCL4 CCL3
7 chronic pain 10.7
8 headache 10.6
9 post-traumatic stress disorder 10.5
10 head injury 10.5
11 fibromyalgia 10.4
12 allergic disease 10.4
13 back pain 10.4
14 acute stress disorder 10.3
15 traumatic brain injury 10.2
16 allergic encephalomyelitis 10.2 CCL5 CCL3
17 respiratory syncytial virus infectious disease 10.2 CCL5 CCL3
18 latex allergy 10.2 CCL4 CCL3
19 african tick-bite fever 10.2 CCL5 CCL3
20 chronic eosinophilic pneumonia 10.2 CCL5 CCL3
21 migraine with or without aura 1 10.2
22 amnestic disorder 10.2
23 spondylosis 10.2
24 thoracic outlet syndrome 10.2
25 chronic fatigue syndrome 10.2
26 brain injury 10.2
27 submandibular gland cancer 10.2 CCR5 CCL3
28 polyradiculoneuropathy 10.1 CCL5 CCL4
29 duodenum adenoma 10.1 CCR5 CCL4
30 complex regional pain syndrome 10.1 CCL4 CCL3
31 chronic inflammatory demyelinating polyradiculoneuropathy 10.1 CCL5 CCL4
32 neurotic disorder 10.1
33 chronic graft versus host disease 10.1 CCR5 CCL5
34 mesangial proliferative glomerulonephritis 10.1 CCR5 CCL3
35 proliferative glomerulonephritis 10.1 CCR5 CCL3
36 pulmonary eosinophilia 10.1 CCL5 CCL3
37 mast-cell leukemia 10.1 CCL5 CCL3
38 oral lichen planus 10.1 CCR5 CCL5
39 temporomandibular joint anomaly 10.1
40 vaginal disease 10.1 CCR5 CCL5
41 mycetoma 10.1 COMT CCL5
42 tick-borne encephalitis 10.1 CCR5 CCL3
43 somatization disorder 10.0
44 poliomyelitis 10.0
45 pathologic nystagmus 10.0
46 spinal cord injury 10.0
47 autoimmune uveitis 10.0 CCR5 CCL3
48 stachybotrys chartarum 10.0 CCL5 CCL4 CCL3
49 tropical spastic paraparesis 10.0 CCL5 CCL3
50 periapical granuloma 10.0 CCL5 CCL4 CCL3

Graphical network of the top 20 diseases related to Whiplash:



Diseases related to Whiplash
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Symptoms & Phenotypes for Whiplash

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Drugs & Therapeutics for Whiplash

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Drugs for Whiplash (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
2
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
3
Amitriptyline Approved Phase 2 50-48-6 2160
4
Ibuprofen Approved Phase 2 15687-27-1 3672
5
Cyclobenzaprine Approved Phase 2 303-53-7 2895
6 Hydrocortisone hemisuccinate Phase 2
7 Hydrocortisone 17-butyrate 21-propionate Phase 2
8 Psychotropic Drugs Phase 2
9 Amitriptyline, perphenazine drug combination Phase 2
10 Antirheumatic Agents Phase 2
11 Neurotransmitter Agents Phase 2
12 Antidepressive Agents, Tricyclic Phase 2
13 Cyclooxygenase Inhibitors Phase 2
14 Anti-Inflammatory Agents Phase 2
15 Adrenergic Agents Phase 2
16 Antidepressive Agents Phase 2
17 Anti-Inflammatory Agents, Non-Steroidal Phase 2
18
Mannitol Approved, Investigational 69-65-8 453 6251
19
Triamcinolone Approved, Vet_approved 124-94-7 31307
20
Levobupivacaine Approved, Investigational 27262-47-1 92253
21
Citalopram Approved 59729-33-8 2771
22
Norepinephrine Approved 51-41-2 439260
23
tannic acid Approved 1401-55-4
24
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
25
Ethanol Approved 64-17-5 702
26
Nicotine Approved 54-11-5 942 89594
27
Caffeine Approved 58-08-2 2519
28
Imidacloprid Vet_approved 105827-78-9 86418
29
Dexetimide Withdrawn 21888-98-2
30 Pharmaceutical Solutions
31 Immunologic Factors Early Phase 1
32 Vaccines Early Phase 1
33 Pyranoprofen
34 Triamcinolone hexacetonide
35 Triamcinolone diacetate
36 triamcinolone acetonide
37 Cholinergic Agents
38 Cholinergic Antagonists
39 Parasympatholytics
40 Serotonin Uptake Inhibitors
41 Muscarinic Antagonists
42 Antiparkinson Agents
43 Atomoxetine Hydrochloride
44 Anti-Infective Agents, Local
45 Analgesics, Non-Narcotic
46 Analgesics
47
Serotonin Investigational, Nutraceutical 50-67-9 5202

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Lidocaine Injection Versus Sham Needling in Treating Whiplash Associated disorder-a Randomized Controlled Trial Withdrawn NCT02060734 Phase 4
2 The University Health Network Whiplash Intervention Trial: A Randomized Controlled Trial of the Effectiveness and Cost-effectiveness of Three Programs of Care for the Treatment of Whiplash-associated Disorders Completed NCT00546806 Phase 3
3 A Randomized Early Intervention Study Comparing the Effect of Stiff Neck Collar, "Act-as-Usual" and Active Mobilisation on the One Year Outcome Following Whiplash Injury. Completed NCT00206271 Phase 3
4 Preventing Chronic Whiplash Pain: Biobehavioral Approach Completed NCT00021476 Phase 3
5 Manual Therapy Dosage Factorial Study Withdrawn NCT00560807 Phase 2, Phase 3
6 The Association Between Low Cortisol Level and Whiplash Syndrome and the Effect of a Single Hydrocortisone Injection on Neck Symptoms Among Motor Vehicle Accident Victims: a Randomized Placebo Controlled Double Blinded Study Unknown status NCT02090309 Phase 2 Hydrocortisone;normal saline 0.9%
7 Comparison of Ibuprofen, Cyclobenzaprine, or Both for Acute Cervical Strain: A Randomized Clinical Trial Completed NCT00790270 Phase 2 Cyclobenzaprine;Ibuprofen;Ibuprofen plus Cyclobenzaprine
8 Does Acupuncture Activate Endogenous Pain Inhibition in Chronic Whiplash Associated Disorders? A Randomized Cross-over Trial Completed NCT01512576 Phase 2
9 Acupuncture for Whiplash Associated Disorder: a Randomised, Waiting-list Controlled, Open-label, Parallel-group Pilot Trial Completed NCT01395511 Phase 2
10 Central Sensitization in Chronic Whiplash Patients: Metabolite Concentrations in the Anterior Cingulate Cortex and Periacueductal Gray Matter Unknown status NCT03005691
11 A Pilot Case Randomized Control Study Analysing the Effectiveness of 3 Needling Techniques: Intramuscular Stimulation, Neural Prolotherapy, and Myofascial Release in the Treatment of Chronic Whiplash Associated Disorder. Unknown status NCT01824810
12 A Randomized Controlled Trial Evaluating the Effect of an Information Video in a Acute Whiplash Population Unknown status NCT02570659
13 Why Does Acute Post Whiplash Injury Pain Transform Into Chronic Pain? Multi-modal Assessment of Risk Factors and Predictors of Pain Chronification Unknown status NCT02560675
14 Efficacy of Pain Neurophysiology Education in Combination With Psychologic Inoculation in Chronic Whiplash Associated Disorders : a Double-blind Randomised Controlled Trial Unknown status NCT01544075 Early Phase 1
15 Clinical Research on the Efficacy of East-West Collaborative Medicine Using Bee-Venom Acupuncture Therapy on Whiplash-Associated Disorders After Traffic Collisions; A Randomized, Controlled, Parallel Trial Unknown status NCT01369238 zaltoprofen
16 A Randomized Controlled Trial Which Compare the Effectiveness of an APOS Kit With Short Waves Therapy for Treating Whiplash Associated Disorders Unknown status NCT00266981
17 Effectiveness of Conservative Multimodal Physiotherapy in Chronic Whiplash-associated Disorders With Facet-mediated Pain Undergoing Platelet Rich Plasma (PRP) Treatment: a Series of Single Case Experimental Designs (SCEDs). Unknown status NCT03949959
18 Diffuse Noxious Inhibitory Controls (DNIC): Nociceptive Modulation and Interaction With Neurocognitive Performance in Chronic Pain Unknown status NCT01172795
19 Advantages of the Paramedian Approach for Cervical Epidural Steroid Injections: A Clinical Comparison in Cervical Epidural Pressure Changes Between Midline and Paramedian Approaches Unknown status NCT01360138
20 Whiplash Associated Disorders - Sensory Changes During Rehabilitation Completed NCT03784196
21 Neuromuscular Mechanisms Underlying Poor Recovery From Whiplash Injuries Completed NCT02157038
22 Clinical and Biological Responses of People With Neck Pain Being Treated With Varying Doses of Manual Therapy: A Pilot Study Completed NCT01957033
23 Effectiveness of an Educational Video Following Acute Whiplash Trauma: A Randomized Controlled Trial Completed NCT01699334
24 The Effect of TheraBand® Kinesiology Tape on Post-manipulation Pain and Range of Motion Completed NCT02691143
25 Value-based Cognitive Behavioural Therapy for the Prevention of Chronic Whiplash Associated Disorders: A Randomized Controlled Trial Completed NCT02251028
26 Neck Exercises, Physical and Cognitive Behavioural Graded Activity as a Treatment for Adult Whiplash Patients With Chronic Neck Pain Completed NCT01431261
27 Unraveling the Nature of Impaired Pain Inhibition in Patients With Chronic Whiplash-associated Disorders: a Randomized Controlled Clinical Trial for the Treatment of Central Sensitization Completed NCT01601912 Atomoxetine;Citalopram
28 Evaluation of a Novel Intervention to Promote Engagement in Physical Activity for Individuals With Whiplash Associated Disorder: a Multiple-baseline, Single Case Experimental Study Completed NCT03729856
29 Is Chronic Whiplash-associated Pain of Neurogenic Origin? A Study Protocol of a Randomized Controlled Trial Comparing Neurolysis of Peripheral Nerves With Traditional Neck-specific Exercise Completed NCT02692937
30 Efficacy of the Use of Dry Needling in Conventional Non-invasive Treatment of Acute and Subacute Whiplash Completed NCT03502928
31 Neck Muscle Activation in Patients With Long Standing Problems After a Whiplash Trauma Registered With Ultrasound With Speckle Tracking Completed NCT01547624
32 Effects of Different Exercise Programs for People With Chronic Whiplash Associated Disorders: a Prospective Randomized Study Completed NCT01528579
33 Is E-health a Way to Increase Ability and Health and Make Health Care More Effective in Chronic Whiplash? A Prospective Randomized Controlled Multicenter Trial Completed NCT03022812
34 The Efficacy and Safety of Trapezius MSAT on Inpatients With Acute Whiplash Injury Caused by Traffic Accidents: A Randomized Controlled Trials Completed NCT04113824
35 Measuring the Impact of the French Version of the Whiplash Book on Both Treatment Approach and Fears and Beliefs Among Emergency Physicians Completed NCT03040245
36 Effects of a Single Dry Needling Session of the Obliquus Capitis Inferior on the Altered Sensorimotor Function in People With Neck Pain: a Random Control Trial Completed NCT03838224
37 Treating Selected Chronic WAD Patients: Cervical Fusion or Multidimensional Rehabilitation. A Randomized Study Completed NCT01994044
38 Short-Term Effects of a Manual Therapy Protocol Completed NCT01825460
39 Free Fall Acrobatics to Reduce Neck Loads During Parachute Opening Shock: Evaluation of an Intervention. Completed NCT02625896
40 The Analysis for Factors Affecting Termination of Treatment and Treatment Satisfaction of Korean Medicine in Traffic Accident Injury Patients: A Retrospective Study With Survey Completed NCT04167930
41 Pathophysiological Mechanism Behind Prolonged Whiplash Associated Disorders Recruiting NCT03664934
42 Evidence for Central Sensitization in Patients With Chronic Whiplash Associated Disorders Based on Self-reported Outcomes of Pain (Beliefs), Disability, Central Sensitization, Quantitative Sensory Testing, and Electro-encephalography. Recruiting NCT04204525
43 Effectiveness of Ultrasound Guided Intermediate Cervical Plexus Block (iCPB) in Patients With Refractory Chronic Neck Pain From Whiplash Associated Disorder (WAD): an Observational Study Recruiting NCT04622020
44 Shifting Away From Pain: Neurocognitive Approach to Explain and Predict the Response to the Modern Neuroscience Approach for Treating Patients With Whiplash Associated Disorders Recruiting NCT04077619
45 The Effect of Non-resistance Technique for Inpatients With Acute Neck Pain Due to a Whiplash Injury: A Randomized Controlled Trial Recruiting NCT04660175 Korean herbal medicine
46 Contemporary Pain Neuroscience Compared to Usual Care Evidence-based Physiotherapy Applied to Chronic Pain in Patients With Chronic Whiplash Associated Disorders: Can we Decrease Central Sensitization? Recruiting NCT03239938
47 Cervico-vestibular Rehabilitation for Mild Traumatic Brain Injury - A Randomized Clinical Trial Recruiting NCT03677661
48 Effects of Virtual Reality Motor Control Rehabilitation in Neck Pain Subjects Recruiting NCT03987334
49 MaNeS (Maastricht Neck Study): Development of Chronic Disability in Neck Pain Patients After a Motor Vehicle Accident Terminated NCT00952510

Search NIH Clinical Center for Whiplash

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Genetic Tests for Whiplash

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Anatomical Context for Whiplash

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MalaCards organs/tissues related to Whiplash:

40
Eye, Spinal Cord, Brain, Cortex, Cingulate Cortex, Dorsal Root Ganglion, Pituitary
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Publications for Whiplash

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Articles related to Whiplash:

(show top 50) (show all 3098)
# Title Authors PMID Year
1
Trauma-focused cognitive behavioural therapy and exercise for chronic whiplash with comorbid posttraumatic stress disorder: a randomised controlled trial. 61
33086286 2021
2
Whiplash-Associated Dysphagia and Dysphonia: A Scoping Review. 61
32445061 2021
3
A model to differentiate WAD patients and people with abnormal pain behaviour based on biomechanical and self-reported tests. 61
33774707 2021
4
Enhanced amygdala-frontal operculum functional connectivity during rest in women with chronic neck pain: Associations with impaired conditioned pain modulation. 61
33812304 2021
5
Efficacy and Long-term Effect of Radiofrequency Denervation in Patients with Clinically Diagnosed Cervical Facet Joint Pain: A Double-blind Randomized Controlled Trial. 61
33534439 2021
6
Cervical Muscle Activation Due to an Applied Force in Response to Different Types of Acoustic Warnings. 61
33768412 2021
7
Combining Stress Management With Pain Neuroscience Education and Exercise Therapy in People With Whiplash-Associated Disorders: A Clinical Perspective. 61
33764474 2021
8
Head- and neck-related symptoms post-motor vehicle collision (MVC): Separate entities or two-sides of the same coin? 61
33731289 2021
9
An updated brief overview on post-traumatic headache and a systematic review of the non-pharmacological interventions for its management. 61
33682560 2021
10
A Diagnosis of Multiple Sclerosis Following Whiplash Injury: Is There a True Association? 61
33758706 2021
11
Cues for feigning screening in whiplash associated disorders. 61
33254095 2021
12
Comparing the Accuracy of WhipPredict and a Modified Version of the Short Form Örebro Musculoskeletal Pain Screening Questionnaire: Which Tool Is Better for Predicting Poor Recovery After Whiplash Injury? 61
33607916 2021
13
Retrospective evaluation of vehicle whiplash-reducing head restraint systems to prevent whiplash injury in Victoria, Australia. 61
33341682 2021
14
Optimization of Female Head-Neck Model with Active Reflexive Cervical Muscles in Low Severity Rear Impact Collisions. 61
32333133 2021
15
Adoption of a research-based program for neck disorders implemented in primary care physiotherapy: a short- and long-term follow-up survey study. 61
31030585 2021
16
Self-efficacy beliefs mediate the association between pain intensity and pain interference in acute/subacute whiplash-associated disorders. 61
33502610 2021
17
Prevalence of whiplash injury and its association with quality of life in local residents in Japan: A cross sectional study. 61
33422390 2021
18
Video-nystagmographic evidence in more than 700 consecutive cases of road traffic whiplash injury. 61
33476974 2021
19
Self-reported Dysphagia and Pharyngeal Volume Following Whiplash Injury. 61
33386482 2021
20
Magnetic Resonance Spectroscopy Assessment of Brain Metabolite Concentrations in Individuals With Chronic Whiplash-associated Disorder: A Cross-sectional Study. 61
33093341 2021
21
Prescription of exercises for the treatment of chronic pain along the continuum of nociplastic pain: A systematic review with meta-analysis. 61
32976664 2021
22
How similar are whiplash and mild traumatic brain injury? A systematic review. 61
33529694 2021
23
Analysis of neurological symptoms and mechanisms in dislocation, sprains and strains of joints and ligaments at neck level. 61
33387428 2020
24
Retrospective analysis of trauma incidence in patients with temporomandibular disorders. 61
32575165 2020
25
The Research Trends of Pharmacopuncture Therapy on Cervical Pain Caused by Traffic Accidents. 61
33408896 2020
26
Changes in Muscle Morphology in Female Chronic Neck Pain Patients Using Magnetic Resonance Imaging. 61
33290364 2020
27
Physiotherapists' lived experiences of decision making in therapeutic encounters with persons suffering from whiplash-associated disorder: A hermeneutic phenomenological study. 61
32677355 2020
28
Laterality judgment performance between people with chronic pain and pain-free individuals. A systematic review and meta-analysis. 61
30686110 2020
29
The Long-Term Impact of Whiplash Injuries on Patient Symptoms and the Associated Degenerative Changes Detected Using MRI: A Prospective 20-Year follow-up Study Comparing Patients with Whiplash-Associated Disorders with Asymptomatic Subjects. 61
33394988 2020
30
Macromolecular changes in spinal cord white matter characterize whiplash outcome at 1-year post motor vehicle collision. 61
33335188 2020
31
Convergent Validity of the Central Sensitization Inventory in Chronic Whiplash-Associated Disorders; Associations with Quantitative Sensory Testing, Pain Intensity, Fatigue, and Psychosocial Factors. 61
32935129 2020
32
A Comparison of Perceptions of Reassurance in Patients with Nontraumatic Neck Pain and Whiplash-Associated Disorders in Consultations with Primary Care Practitioners-An Online Survey. 61
33036025 2020
33
[Whiplash in insurance medicine: lessons for physicians]. 61
33332055 2020
34
Revisiting Risk-stratified Whiplash-exposed Patients 12 to 14 Years After Injury. 61
32826406 2020
35
The Analysis of Korean Clinical Studies on the Effect of Pharmacopuncture for Whiplash Injury after Traffic Accidents. 61
33408902 2020
36
Management of Acute Pain From Non-Low Back, Musculoskeletal Injuries : A Systematic Review and Network Meta-analysis of Randomized Trials. 61
32805127 2020
37
Correction: Do measures of physical function enhance the prediction of persistent pain and disability following a whiplash injury? Protocol for a prospective observational study in Spain. 61
33444220 2020
38
Preventable fatal injury during rally race: a multidisciplinary approach. 61
33237457 2020
39
Cross-cultural adaptation and validation of the Dutch language version of the Pictorial Fear of Activity Scale - Cervical. 61
33115471 2020
40
Study of the Emergency Braking Test with an Autonomous Bus and the sEMG Neck Response by Means of a Low-Cost System. 61
33066252 2020
41
Do measures of physical function enhance the prediction of persistent pain and disability following a whiplash injury? Protocol for a prospective observational study in Spain. 61
33033010 2020
42
Whiplash Injuries. Current State of Knowledge. 61
33568566 2020
43
Contribution of the neuropsychological assessment in concussion. 61
33049285 2020
44
A contemporary neuroscience approach compared to biomedically focused education combined with symptom-contingent exercise therapy in people with chronic whiplash associated disorders: a randomized controlled trial protocol. 61
33109480 2020
45
Systemic inflammatory markers in neck pain: A systematic review with meta-analysis. 61
32621397 2020
46
Processing of Laser-Evoked Potentials in Patients with Chronic Whiplash-Associated Disorders, Chronic Fatigue Syndrome, and Healthy Controls: A Case-Control Study. 61
32289826 2020
47
Clinical effectiveness of manipulation and mobilisation interventions for the treatment of non-specific neck pain: protocol for a systematic review and meta-analysis. 61
33040001 2020
48
Can measuring passive neck muscle stiffness in whiplash injury patients help detect false whiplash claims? 61
32189119 2020
49
The mechanisms of effect of a physiotherapist-delivered integrated psychological and exercise intervention for acute whiplash-associated disorders: secondary mediation analysis of a randomized controlled trial. 61
33490837 2020
50
Whiplash injury successfully treated with prolotherapy: a case report with long-term follow up. 61
33259262 2020
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Variations for Whiplash

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Expression for Whiplash

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Search GEO for disease gene expression data for Whiplash.
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Pathways for Whiplash

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Pathways related to Whiplash according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
PEDF Induced Signaling 63
Show member pathways
 13.26 IL16 CCR5 CCL5 CCL4 CCL3
2
Akt Signaling 63
Show member pathways
 13 IL16 CCR5 CCL5 CCL4 CCL3
3
Cytokine Signaling in Immune system 65
Show member pathways
 12.91 IL16 CCR5 CCL5 CCL4 CCL3
4
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.81 KNG1 CCL5 CCL4 CCL3
5
PAK Pathway 63
Show member pathways
 12.79 IL16 CCR5 CCL5 CCL4 CCL3
6
Human cytomegalovirus infection 36
Show member pathways
 12.58 CCR5 CCL5 CCL4 CCL3
7
CCR5 Pathway in Macrophages 63
Show member pathways
 12.49 CCR5 CCL5 CCL4 CCL3
8
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 11.59 CCR5 CCL5 CCL4 CCL3
9
IL12-mediated signaling events 1
Show member pathways
 11.49 CCR5 CCL4 CCL3
10
Lung fibrosis 1
11.13 CCL5 CCL4 CCL3
11
IL-15 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
Show member pathways
 11.05 CCL4 CCL3
12
Interleukin-10 signaling 65
10.61 CCR5 CCL5 CCL4 CCL3
13
G-protein signaling_Rap2B regulation pathway 23
10.57 IL16 CCL5 CCL4 CCL3
Sources

GO Terms for Whiplash

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Cellular components related to Whiplash according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 KNG1 IL16 CCL5 CCL4 CCL3

Biological processes related to Whiplash according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.06 IL16 CCR5 CCL5 CCL4 CCL3
2 G protein-coupled receptor signaling pathway GO:0007186 10.02 KNG1 CCR5 CCL5 CCL4 CCL3
3 immune response GO:0006955 9.88 IL16 CCR5 CCL5 CCL4 CCL3
4 positive regulation of GTPase activity GO:0043547 9.83 CCL5 CCL4 CCL3
5 MAPK cascade GO:0000165 9.83 CCR5 CCL5 CCL3
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.81 CCL5 CCL4 CCL3
7 cell-cell signaling GO:0007267 9.81 CCR5 CCL5 CCL4 CCL3
8 inflammatory response GO:0006954 9.8 KNG1 CCR5 CCL5 CCL4 CCL3
9 calcium ion transport GO:0006816 9.79 CCR5 CCL5 CCL3
10 cellular response to tumor necrosis factor GO:0071356 9.78 CCL5 CCL4 CCL3
11 cellular response to interferon-gamma GO:0071346 9.75 CCL5 CCL4 CCL3
12 response to toxic substance GO:0009636 9.73 CCL5 CCL4 CCL3
13 cell chemotaxis GO:0060326 9.72 CCR5 CCL5 CCL3
14 cytokine-mediated signaling pathway GO:0019221 9.72 IL16 CCR5 CCL5 CCL4 CCL3
15 cellular response to interleukin-1 GO:0071347 9.71 CCL5 CCL4 CCL3
16 neutrophil chemotaxis GO:0030593 9.7 CCL5 CCL4 CCL3
17 cellular response to organic cyclic compound GO:0071407 9.67 CCL5 CCL3
18 monocyte chemotaxis GO:0002548 9.67 CCL5 CCL4 CCL3
19 positive chemotaxis GO:0050918 9.65 CCL5 CCL3
20 protein kinase B signaling GO:0043491 9.65 CCL5 CCL3
21 regulation of sensory perception of pain GO:0051930 9.64 COMT CCL3
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.64 CCL5 CCL3
23 dendritic cell chemotaxis GO:0002407 9.63 CCR5 CCL5
24 lymphocyte chemotaxis GO:0048247 9.63 CCL5 CCL4 CCL3
25 positive regulation of calcium-mediated signaling GO:0050850 9.62 CCL4 CCL3
26 positive regulation of calcium ion transport GO:0051928 9.61 CCL5 CCL4 CCL3
27 macrophage chemotaxis GO:0048246 9.6 CCL5 CCL3
28 response to cholesterol GO:0070723 9.59 CCR5 CCL3
29 signaling GO:0023052 9.58 CCR5 CCL3
30 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.57 CCR5 CCL3
31 eosinophil chemotaxis GO:0048245 9.54 CCL5 CCL4 CCL3
32 chemokine-mediated signaling pathway GO:0070098 9.46 CCR5 CCL5 CCL4 CCL3
33 negative regulation by host of viral transcription GO:0043922 9.43 CCL5 CCL4 CCL3
34 positive regulation of natural killer cell chemotaxis GO:2000503 9.13 CCL5 CCL4 CCL3
35 chemotaxis GO:0006935 9.02 IL16 CCR5 CCL5 CCL4 CCL3

Molecular functions related to Whiplash according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.62 IL16 CCL5 CCL4 CCL3
2 chemoattractant activity GO:0042056 9.43 CCL5 CCL3
3 chemokine activity GO:0008009 9.43 CCL5 CCL4 CCL3
4 phosphatidylinositol phospholipase C activity GO:0004435 9.4 CCR5 CCL5
5 phospholipase activator activity GO:0016004 9.37 CCL5 CCL3
6 CCR chemokine receptor binding GO:0048020 9.33 CCL5 CCL4 CCL3
7 CCR5 chemokine receptor binding GO:0031730 9.13 CCL5 CCL4 CCL3
8 CCR1 chemokine receptor binding GO:0031726 8.8 CCL5 CCL4 CCL3
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Sources for Whiplash

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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