MCID: WHP001
MIFTS: 50

Whipple Disease

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Whipple Disease

MalaCards integrated aliases for Whipple Disease:

Name: Whipple Disease 12 76 53 59 44 15 73
Intestinal Lipodystrophy 12 76 53 54 59
Intestinal Lipophagic Granulomatosis 53 59 73
Secondary Non-Tropical Sprue 53 59
Whipple's Disease 12 54
Tropheryma Whippelii Infection 53
Whipples Disease 55

Characteristics:

Orphanet epidemiological data:

59
whipple disease
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Italy); Age of onset: All ages;

Classifications:



Summaries for Whipple Disease

NINDS : 54 Whipple's disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. Caused by the bacterium Tropheryma whipplei, the disorder can affect any system in the body, including the brain, eyes, heart, joints, and lungs, but usually occurs in the gastrointestinal system. Neurological symptoms occur in up to 40 percent of individuals and may include dementia, abnormalities of eye and facial muscle movements, headaches, seizures, loss of muscle control, memory loss, weakness, and vision problems. Gastrointestinal symptoms may include diarrhea, weight loss, fatigue, weakness, and abdominal bleeding and pain. Fever, cough, anemia, heart and lung damage, darkening of the skin, and joint soreness may also be present. The disease is more common in men and neurological symptoms are more common in individuals who have severe abdominal disease. Rarely, neurological symptoms may appear without gastrointestinal symptoms and can mimic symptoms of almost any neurologic disease.

MalaCards based summary : Whipple Disease, also known as intestinal lipodystrophy, is related to hypersomnia and panuveitis. An important gene associated with Whipple Disease is IL16 (Interleukin 16), and among its related pathways/superpathways are Epstein-Barr virus infection and Tuberculosis. Affiliated tissues include brain, lung and heart, and related phenotypes are hydrocephalus and depressivity

NIH Rare Diseases : 53 Whipple disease is an infectious bacterial disease that affects many different organ systems and interferes with the body's ability to process (metabolize) fats. The disease usually occurs in the gastrointestinal system, but may affect any part of the body including the heart, lungs, brain, joints, and eyes. In the gastrointestinal system, it interferes with the body's ability to absorb certain nutrients. This leads to a condition known as malabsorption. Whipple disease causes weight loss, incomplete breakdown of carbohydrates or fats, and problems with the immune system. It is caused by infection from bacteria called Tropheryma whipplei. When recognized and treated, Whipple disease can usually be cured. Untreated, the disease may be fatal.

Wikipedia : 76 Whipple''s disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei.... more...

Related Diseases for Whipple Disease

Diseases related to Whipple Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 hypersomnia 29.8 HLA-DQB1 HLA-DRB1
2 panuveitis 29.5 HLA-DQB1 HLA-DRB1 MRAP
3 limbic encephalitis with lgi1 antibodies 10.1 HLA-DQB1 HLA-DRB1
4 narcolepsy 2 10.1 HLA-DQB1 HLA-DRB1
5 autoimmune polyglandular syndrome type 3 10.1 HLA-DQB1 HLA-DRB1
6 metal allergy 10.1 HLA-DQB1 HLA-DRB1
7 lichen planopilaris 10.1 HLA-DQB1 HLA-DRB1
8 type ii mixed cryoglobulinemia 10.1 HLA-DQB1 HLA-DRB1
9 actinic prurigo 10.1 CD58 HLA-DRB1
10 beryllium disease 10.1 HLA-DQB1 HLA-DRB1
11 recurrent respiratory papillomatosis 10.1 HLA-DQB1 HLA-DRB1
12 narcolepsy 1 10.1 HLA-DQB1 HLA-DRB1
13 chronic beryllium disease 10.1 HLA-DQB1 HLA-DRB1
14 lichen sclerosus 10.1 HLA-DQB1 HLA-DRB1
15 pityriasis rosea 10.1 HLA-DQB1 HLA-DRB1
16 pediatric multiple sclerosis 10.1 HLA-DQB1 HLA-DRB1
17 microscopic colitis 10.1 HLA-DQB1 HLA-DRB1
18 osteonecrosis of the jaw 10.1 HLA-DQB1 HLA-DRB1
19 idiopathic bronchiectasis 10.1 HLA-DQB1 HLA-DRB1
20 peanut allergy 10.1 HLA-DQB1 HLA-DRB1
21 oligoarticular juvenile idiopathic arthritis 10.1 HLA-DQB1 HLA-DRB1
22 inclusion conjunctivitis 10.1 IL16 MRAP
23 geographic tongue 10.1 HLA-DQB1 HLA-DRB1
24 ocular cicatricial pemphigoid 10.1 HLA-DQB1 HLA-DRB1
25 focal epithelial hyperplasia 10.1 HLA-DQB1 HLA-DRB1
26 paraneoplastic pemphigus 10.0 HLA-DQB1 HLA-DRB1
27 palindromic rheumatism 10.0 HLA-DRB1 MRAP
28 vogt-koyanagi-harada disease 10.0 HLA-DQB1 HLA-DRB1
29 rubella 10.0 HLA-DQB1 HLA-DRB1
30 urethritis 10.0 HSPD1 MRAP
31 oral lichen planus 10.0 CD58 HSPD1
32 cervicitis 10.0 HSPD1 MRAP
33 mesenteric lymphadenitis 10.0 HSPD1 MRAP
34 pulmonary hypertension 10.0
35 arthritis 10.0
36 mixed connective tissue disease 10.0 HLA-DRB1 HSPD1
37 graft-versus-host disease 10.0 HLA-DQB1 HLA-DRB1
38 leprosy 3 10.0 HLA-DRB1 HSPD1
39 bone inflammation disease 10.0 HLA-DRB1 MRAP
40 glaucomatocyclitic crisis 9.9 HLA-DQB1 HLA-DRB1 MRAP
41 autoimmune hepatitis 9.9 HLA-DQB1 HLA-DRB1
42 acute disseminated encephalomyelitis 9.9 HLA-DQB1 HLA-DRB1 HSPD1
43 uveitis 9.9
44 diabetes mellitus, insulin-dependent 9.9 HLA-DQB1 HLA-DRB1 HSPD1
45 bullous pemphigoid 9.9 HLA-DQB1 HLA-DRB1
46 autoimmune disease 9.8 HLA-DQB1 HLA-DRB1 HSPD1
47 aceruloplasminemia 9.7
48 keratopathy 9.7
49 thrombosis 9.7
50 endocarditis 9.7

Graphical network of the top 20 diseases related to Whipple Disease:



Diseases related to Whipple Disease

Symptoms & Phenotypes for Whipple Disease

Human phenotypes related to Whipple Disease:

59 32 (show all 48)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hydrocephalus 59 32 occasional (7.5%) Occasional (29-5%) HP:0000238
2 depressivity 59 32 hallmark (90%) Very frequent (99-80%) HP:0000716
3 hypothyroidism 59 32 occasional (7.5%) Occasional (29-5%) HP:0000821
4 seizures 59 32 occasional (7.5%) Occasional (29-5%) HP:0001250
5 ataxia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001251
6 muscle weakness 59 32 occasional (7.5%) Occasional (29-5%) HP:0001324
7 respiratory insufficiency 59 32 occasional (7.5%) Occasional (29-5%) HP:0002093
8 sleep disturbance 59 32 frequent (33%) Frequent (79-30%) HP:0002360
9 developmental regression 59 32 hallmark (90%) Very frequent (99-80%) HP:0002376
10 encephalitis 59 32 occasional (7.5%) Occasional (29-5%) HP:0002383
11 hypotension 59 32 frequent (33%) Frequent (79-30%) HP:0002615
12 arthritis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001369
13 splenomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0001744
14 hepatomegaly 59 32 frequent (33%) Frequent (79-30%) HP:0002240
15 increased intracranial pressure 59 32 occasional (7.5%) Occasional (29-5%) HP:0002516
16 malabsorption 59 32 hallmark (90%) Very frequent (99-80%) HP:0002024
17 fever 59 32 hallmark (90%) Very frequent (99-80%) HP:0001945
18 polydipsia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001959
19 cranial nerve paralysis 59 32 occasional (7.5%) Occasional (29-5%) HP:0006824
20 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
21 arthralgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002829
22 anemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0001903
23 myocardial infarction 59 32 occasional (7.5%) Occasional (29-5%) HP:0001658
24 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0002027
25 peripheral neuropathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0009830
26 myoclonus 59 32 hallmark (90%) Very frequent (99-80%) HP:0001336
27 anorexia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002039
28 myalgia 59 32 frequent (33%) Frequent (79-30%) HP:0003326
29 cachexia 59 32 hallmark (90%) Very frequent (99-80%) HP:0004326
30 gastrointestinal hemorrhage 59 32 occasional (7.5%) Occasional (29-5%) HP:0002239
31 chest pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0100749
32 hyponatremia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002902
33 diarrhea 59 32 hallmark (90%) Very frequent (99-80%) HP:0002014
34 pericarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0001701
35 myocarditis 59 32 occasional (7.5%) Occasional (29-5%) HP:0012819
36 cough 59 32 occasional (7.5%) Occasional (29-5%) HP:0012735
37 erectile abnormalities 59 32 occasional (7.5%) Occasional (29-5%) HP:0100639
38 proptosis 59 32 occasional (7.5%) Occasional (29-5%) HP:0000520
39 mediastinal lymphadenopathy 59 32 hallmark (90%) Very frequent (99-80%) HP:0100721
40 generalized hyperpigmentation 59 32 occasional (7.5%) Occasional (29-5%) HP:0007440
41 myositis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100614
42 edema of the lower limbs 59 32 occasional (7.5%) Occasional (29-5%) HP:0010741
43 uveitis 59 32 frequent (33%) Frequent (79-30%) HP:0000554
44 galactorrhea 59 32 occasional (7.5%) Occasional (29-5%) HP:0100829
45 insulin resistance 59 32 occasional (7.5%) Occasional (29-5%) HP:0000855
46 pleuritis 59 32 frequent (33%) Frequent (79-30%) HP:0002102
47 abnormal pyramidal signs 59 Occasional (29-5%)
48 abnormal pyramidal sign 32 occasional (7.5%) HP:0007256

Drugs & Therapeutics for Whipple Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Detection and Characteristic of Whipple Diseases in the Great Britany Completed NCT03350685
2 Chronic Infection With Tropheryma Whipplei: Risk Factors Related to the Host Recruiting NCT02868450 Not Applicable

Search NIH Clinical Center for Whipple Disease

Cochrane evidence based reviews: whipple disease

Genetic Tests for Whipple Disease

Anatomical Context for Whipple Disease

MalaCards organs/tissues related to Whipple Disease:

41
Brain, Lung, Heart, Eye, Skin, Bone, Tongue

Publications for Whipple Disease

Articles related to Whipple Disease:

(show top 50) (show all 152)
# Title Authors Year
1
Whipple Disease Presenting as Cystic Brain Tumor: Case Report and Review of the Literature. ( 29707758 )
2018
2
Tropheryma whipplei Infection (Whipple Disease) in the USA. ( 29572616 )
2018
3
IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease. ( 29769372 )
2018
4
Diagnostic Approach for Classic Compared With Localized Whipple Disease. ( 29992176 )
2018
5
Ocular Whipple Disease: Report of Three Cases. ( 30192690 )
2018
6
From Whipple Disease to Tropheryma whipplei Infection. ( 30351351 )
2018
7
Cytology of cerebrospinal fluid in CNS Whipple disease. ( 28770535 )
2017
8
Genotypic analysis of Tropheryma whipplei from patients with Whipple disease in the Americas. ( 28385924 )
2017
9
Ultrastructural changes of small intestine in Whipple disease patient. ( 28230475 )
2017
10
A case of rapidly progressive dementia: Whipple disease of CNS. ( 29079886 )
2017
11
Pseudo-Whipple Disease Cutaneous Lesions. ( 27097339 )
2016
12
Prosopagnosia as the Presenting Symptom of Whipple Disease. ( 27336807 )
2016
13
Deep Vein Thrombosis as Initial Manifestation of Whipple Disease. ( 27920655 )
2016
14
Whipple disease confined to the central nervous system presenting as a cystic tumor: Case report and review of literature. ( 27593833 )
2016
15
Primary Whipple disease of the brain: case report with long-term clinical and MRI follow-up. ( 26445540 )
2015
16
Gastrointestinal diagnosis of classical whipple disease: clinical, endoscopic, and histopathologic features in 191 patients. ( 25881849 )
2015
17
Atypical presentation of Whipple disease with no diarrhea. ( 26275278 )
2015
18
Specific cutaneous involvement in Whipple disease. ( 24562051 )
2014
19
Bilateral panuveitis associated with Whipple disease - case report. ( 27625936 )
2014
20
Primary Whipple disease of the CNS presenting with chorea and dystonia: A video case report. ( 29443151 )
2014
21
Pulmonary hypertension associated with Whipple disease. ( 25445953 )
2014
22
Neurocognitive impairment in Whipple disease with central nervous system involvement. ( 24674966 )
2014
23
Resolution of whipple disease-induced pulmonary hypertension following antibiotic therapy. ( 23344104 )
2014
24
Monoclonal B-cell lymphocyte proliferation in a patient presenting with historical Whipple disease. ( 23441662 )
2013
25
Rheumatic and musculoskeletal features of Whipple disease: a report of 29 cases. ( 24187107 )
2013
26
Oculomasticatory myorhythmia and agrypnia excitata guide the diagnosis of Whipple disease. ( 24210608 )
2013
27
Central nervous system involvement in Whipple disease: clinical study of 18 patients and long-term follow-up. ( 24145700 )
2013
28
A severe Whipple disease with an immune reconstitution inflammatory syndrome: An additional case of thalidomide efficiency. ( 24289960 )
2013
29
Whipple disease diagnosed with PCR using formalin-fixed paraffin-embedded specimens of the intestinal mucosa. ( 23318851 )
2013
30
Whipple disease revealed by lung involvement: a case report and literature review. ( 22670021 )
2012
31
Whipple disease mimicking adult-onset Still's disease and treated by anakinra: diagnosis using PCR. ( 22639877 )
2012
32
A unique posterior segment manifestation of whipple disease. ( 25390964 )
2012
33
Whipple disease a century after the initial description: increased recognition of unusual presentations, autoimmune comorbidities, and therapy effects. ( 22743287 )
2012
34
Isolated CNS Whipple disease with normal brain MRI and false-positive CSF 14-3-3 protein: a case report and review of the literature. ( 23170246 )
2012
35
Whipple disease with crystalline keratopathy and chronic uveitis. ( 22965603 )
2012
36
Connecting the dots: the many systemic manifestations of whipple disease. ( 22347837 )
2012
37
Treated Whipple disease with erythema nodosum leprosum-like lesions: cutaneous PAS-positive macrophages slowly decrease with time and are associated with lymphangiectases: a case report. ( 22123268 )
2012
38
Whipple disease research accelerates. ( 21628651 )
2011
39
Infection: How should classic Whipple disease be managed? ( 20442732 )
2010
40
The immune reconstitution inflammatory syndrome in whipple disease: a cohort study. ( 21135294 )
2010
41
Whipple disease. ( 20224490 )
2010
42
Intestinal Mycobacterium avium complex infection initially misdiagnosed and mistreated as Whipple disease. ( 20138615 )
2010
43
Whipple disease of the central nervous system: an unusual occurrence in association with acquired immune deficiency syndrome. ( 19612977 )
2010
44
MR imaging of central nervous system Whipple disease: a 15-year review. ( 20395395 )
2010
45
The amnesic syndrome of primary Whipple disease of the brain. ( 20299864 )
2010
46
Isolated Whipple disease of the brain resembling a tumour. ( 19194653 )
2009
47
Renal amyloidosis in Whipple disease: a case report. ( 19918433 )
2009
48
Primary cerebral Whipple disease presenting as KlA1ver-Bucy syndrome. ( 19139312 )
2009
49
Whipple disease: unusual presentation of a protean and sometimes confusing disease. ( 18538828 )
2009
50
A paradoxical Tropheryma whipplei western blot differentiates patients with whipple disease from asymptomatic carriers. ( 19635029 )
2009

Variations for Whipple Disease

Expression for Whipple Disease

Search GEO for disease gene expression data for Whipple Disease.

Pathways for Whipple Disease

Pathways related to Whipple Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.64 CD58 HLA-DQB1 HLA-DRB1
2 11.38 HLA-DQB1 HLA-DRB1 HSPD1
3 11.22 HLA-DQB1 HLA-DRB1
4 11.11 GRPEL1 HSPD1
5 11 HLA-DQB1 HLA-DRB1
6 10.96 CD58 HLA-DQB1 HLA-DRB1

GO Terms for Whipple Disease

Cellular components related to Whipple Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle membrane GO:0030666 9.37 HLA-DQB1 HLA-DRB1
2 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQB1 HLA-DRB1
3 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DRB1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
6 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Whipple Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.54 HLA-DRB1 HSPD1 IL16
2 interferon-gamma-mediated signaling pathway GO:0060333 9.32 HLA-DQB1 HLA-DRB1
3 antigen processing and presentation GO:0019882 9.26 HLA-DQB1 HLA-DRB1
4 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.16 HLA-DQB1 HLA-DRB1
5 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
6 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Whipple Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Whipple Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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