MCID: WHP001
MIFTS: 50

Whipple Disease

Categories: Gastrointestinal diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Whipple Disease

MalaCards integrated aliases for Whipple Disease:

Name: Whipple Disease 12 77 54 60 45 15 74
Intestinal Lipodystrophy 12 77 54 55 60
Intestinal Lipophagic Granulomatosis 54 60 74
Whipple's Disease 12 55 17
Secondary Non-Tropical Sprue 54 60
Tropheryma Whippelii Infection 54
Whipples Disease 56

Characteristics:

Orphanet epidemiological data:

60
whipple disease
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe),1-9/1000000 (Italy); Age of onset: All ages;

Classifications:



Summaries for Whipple Disease

NINDS : 55 Whipple's disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. Caused by the bacterium Tropheryma whipplei, the disorder can affect any system in the body, including the brain, eyes, heart, joints, and lungs, but usually occurs in the gastrointestinal system. Neurological symptoms occur in up to 40 percent of individuals and may include dementia, abnormalities of eye and facial muscle movements, headaches, seizures, loss of muscle control, memory loss, weakness, and vision problems. Gastrointestinal symptoms may include diarrhea, weight loss, fatigue, weakness, and abdominal bleeding and pain. Fever, cough, anemia, heart and lung damage, darkening of the skin, and joint soreness may also be present. The disease is more common in men and neurological symptoms are more common in individuals who have severe abdominal disease. Rarely, neurological symptoms may appear without gastrointestinal symptoms and can mimic symptoms of almost any neurologic disease.

MalaCards based summary : Whipple Disease, also known as intestinal lipodystrophy, is related to hypersomnia and mesenteric lymphadenitis. An important gene associated with Whipple Disease is IL16 (Interleukin 16), and among its related pathways/superpathways are Tuberculosis and CTLA4 Signaling. Affiliated tissues include brain, eye and skin, and related phenotypes are depressivity and developmental regression

NIH Rare Diseases : 54 Whipple disease is an infectious bacterial disease that affects many different organ systems and interferes with the body's ability to process (metabolize) fats. The disease usually occurs in the gastrointestinal system, but may affect any part of the body including the heart, lungs, brain, joints, and eyes. In the gastrointestinal system, it interferes with the body's ability to absorb certain nutrients. This leads to a condition known as malabsorption. Whipple disease causes weight loss, incomplete breakdown of carbohydrates or fats, and problems with the immune system. It is caused by infection from bacteria called Tropheryma whipplei. When recognized and treated, Whipple disease can usually be cured. Untreated, the disease may be fatal.

Wikipedia : 77 Whipple''s disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei.... more...

Related Diseases for Whipple Disease

Diseases related to Whipple Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 hypersomnia 30.1 HLA-DQB1 HLA-DRB1
2 mesenteric lymphadenitis 29.8 HSPD1 MRAP
3 palindromic rheumatism 29.6 HLA-DRB1 MRAP
4 panuveitis 29.5 HLA-DQB1 HLA-DRB1 MRAP
5 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.6
6 limbic encephalitis with lgi1 antibodies 10.2 HLA-DQB1 HLA-DRB1
7 narcolepsy 2 10.2 HLA-DQB1 HLA-DRB1
8 narcolepsy 10.2 HLA-DQB1 HLA-DRB1
9 autoimmune polyglandular syndrome type 3 10.2 HLA-DQB1 HLA-DRB1
10 metal allergy 10.2 HLA-DQB1 HLA-DRB1
11 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
12 type ii mixed cryoglobulinemia 10.2 HLA-DQB1 HLA-DRB1
13 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
14 recurrent respiratory papillomatosis 10.2 HLA-DQB1 HLA-DRB1
15 narcolepsy 1 10.2 HLA-DQB1 HLA-DRB1
16 actinic prurigo 10.2 CD58 HLA-DRB1
17 chronic beryllium disease 10.2 HLA-DQB1 HLA-DRB1
18 lichen sclerosus 10.2 HLA-DQB1 HLA-DRB1
19 pityriasis rosea 10.2 HLA-DQB1 HLA-DRB1
20 pediatric multiple sclerosis 10.2 HLA-DQB1 HLA-DRB1
21 microscopic colitis 10.2 HLA-DQB1 HLA-DRB1
22 osteonecrosis of the jaw 10.1 HLA-DQB1 HLA-DRB1
23 idiopathic bronchiectasis 10.1 HLA-DQB1 HLA-DRB1
24 peanut allergy 10.1 HLA-DQB1 HLA-DRB1
25 pure red-cell aplasia 10.1 HLA-DQB1 HLA-DRB1
26 oligoarticular juvenile idiopathic arthritis 10.1 HLA-DQB1 HLA-DRB1
27 geographic tongue 10.1 HLA-DQB1 HLA-DRB1
28 ocular cicatricial pemphigoid 10.1 HLA-DQB1 HLA-DRB1
29 focal epithelial hyperplasia 10.1 HLA-DQB1 HLA-DRB1
30 pulmonary hypertension 10.1
31 arthritis 10.1
32 myoclonus 10.1
33 pelvic inflammatory disease 10.1 HLA-DQB1 HSPD1
34 inclusion conjunctivitis 10.1 IL16 MRAP
35 paraneoplastic pemphigus 10.0 HLA-DQB1 HLA-DRB1
36 oral lichen planus 10.0 CD58 HSPD1
37 vogt-koyanagi-harada disease 10.0 HLA-DQB1 HLA-DRB1
38 rubella 10.0 HLA-DQB1 HLA-DRB1
39 mixed connective tissue disease 10.0 HLA-DRB1 HSPD1
40 familial mediterranean fever 10.0
41 supranuclear palsy, progressive, 1 10.0
42 colitis 10.0
43 spondyloarthropathy 10.0
44 urethritis 10.0 HSPD1 MRAP
45 uveitis 10.0
46 cervicitis 10.0 HSPD1 MRAP
47 graft-versus-host disease 9.9 HLA-DQB1 HLA-DRB1
48 myositis 9.9
49 celiac disease 1 9.9
50 ulcerative colitis 9.9

Graphical network of the top 20 diseases related to Whipple Disease:



Diseases related to Whipple Disease

Symptoms & Phenotypes for Whipple Disease

Human phenotypes related to Whipple Disease:

60 33 (show all 49)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 depressivity 60 33 hallmark (90%) Very frequent (99-80%) HP:0000716
2 developmental regression 60 33 hallmark (90%) Very frequent (99-80%) HP:0002376
3 arthritis 60 33 hallmark (90%) Very frequent (99-80%) HP:0001369
4 malabsorption 60 33 hallmark (90%) Very frequent (99-80%) HP:0002024
5 fever 60 33 hallmark (90%) Very frequent (99-80%) HP:0001945
6 fatigue 60 33 hallmark (90%) Very frequent (99-80%) HP:0012378
7 arthralgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002829
8 abdominal pain 60 33 hallmark (90%) Very frequent (99-80%) HP:0002027
9 myoclonus 60 33 hallmark (90%) Very frequent (99-80%) HP:0001336
10 anorexia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002039
11 cachexia 60 33 hallmark (90%) Very frequent (99-80%) HP:0004326
12 diarrhea 60 33 hallmark (90%) Very frequent (99-80%) HP:0002014
13 mediastinal lymphadenopathy 60 33 hallmark (90%) Very frequent (99-80%) HP:0100721
14 sleep disturbance 60 33 frequent (33%) Frequent (79-30%) HP:0002360
15 hypotension 60 33 frequent (33%) Frequent (79-30%) HP:0002615
16 splenomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0001744
17 hepatomegaly 60 33 frequent (33%) Frequent (79-30%) HP:0002240
18 myalgia 60 33 frequent (33%) Frequent (79-30%) HP:0003326
19 uveitis 60 33 frequent (33%) Frequent (79-30%) HP:0000554
20 pleuritis 60 33 frequent (33%) Frequent (79-30%) HP:0002102
21 hydrocephalus 60 33 occasional (7.5%) Occasional (29-5%) HP:0000238
22 hypothyroidism 60 33 occasional (7.5%) Occasional (29-5%) HP:0000821
23 seizures 60 33 occasional (7.5%) Occasional (29-5%) HP:0001250
24 ataxia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001251
25 muscle weakness 60 33 occasional (7.5%) Occasional (29-5%) HP:0001324
26 respiratory insufficiency 60 33 occasional (7.5%) Occasional (29-5%) HP:0002093
27 encephalitis 60 33 occasional (7.5%) Occasional (29-5%) HP:0002383
28 increased intracranial pressure 60 33 occasional (7.5%) Occasional (29-5%) HP:0002516
29 polydipsia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001959
30 cranial nerve paralysis 60 33 occasional (7.5%) Occasional (29-5%) HP:0006824
31 anemia 60 33 occasional (7.5%) Occasional (29-5%) HP:0001903
32 myocardial infarction 60 33 occasional (7.5%) Occasional (29-5%) HP:0001658
33 peripheral neuropathy 60 33 occasional (7.5%) Occasional (29-5%) HP:0009830
34 gastrointestinal hemorrhage 60 33 occasional (7.5%) Occasional (29-5%) HP:0002239
35 chest pain 60 33 occasional (7.5%) Occasional (29-5%) HP:0100749
36 hyponatremia 60 33 occasional (7.5%) Occasional (29-5%) HP:0002902
37 pericarditis 60 33 occasional (7.5%) Occasional (29-5%) HP:0001701
38 myocarditis 60 33 occasional (7.5%) Occasional (29-5%) HP:0012819
39 cough 60 33 occasional (7.5%) Occasional (29-5%) HP:0012735
40 erectile abnormalities 60 33 occasional (7.5%) Occasional (29-5%) HP:0100639
41 proptosis 60 33 occasional (7.5%) Occasional (29-5%) HP:0000520
42 generalized hyperpigmentation 60 33 occasional (7.5%) Occasional (29-5%) HP:0007440
43 myositis 60 33 occasional (7.5%) Occasional (29-5%) HP:0100614
44 galactorrhea 60 33 occasional (7.5%) Occasional (29-5%) HP:0100829
45 insulin resistance 60 33 occasional (7.5%) Occasional (29-5%) HP:0000855
46 abnormal pyramidal sign 33 occasional (7.5%) HP:0007256
47 pedal edema 33 occasional (7.5%) HP:0010741
48 abnormal pyramidal signs 60 Occasional (29-5%)
49 edema of the lower limbs 60 Occasional (29-5%)

Drugs & Therapeutics for Whipple Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Detection and Characteristic of Whipple Diseases in the Great Britany Completed NCT03350685
2 Chronic Infection With Tropheryma Whipplei: Risk Factors Related to the Host Recruiting NCT02868450 Not Applicable

Search NIH Clinical Center for Whipple Disease

Cochrane evidence based reviews: whipple disease

Genetic Tests for Whipple Disease

Anatomical Context for Whipple Disease

MalaCards organs/tissues related to Whipple Disease:

42
Brain, Eye, Skin, Lung, Heart, Small Intestine, Spinal Cord

Publications for Whipple Disease

Articles related to Whipple Disease:

(show top 50) (show all 157)
# Title Authors Year
1
Editors' note: IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease. ( 30858246 )
2019
2
Reader response: IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease. ( 30858247 )
2019
3
Author response: IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease. ( 30858248 )
2019
4
Whipple Disease Presenting as Cystic Brain Tumor: Case Report and Review of the Literature. ( 29707758 )
2018
5
Tropheryma whipplei Infection (Whipple Disease) in the USA. ( 29572616 )
2018
6
IgLON5-mediated neurodegeneration is a differential diagnosis of CNS Whipple disease. ( 29769372 )
2018
7
Diagnostic Approach for Classic Compared With Localized Whipple Disease. ( 29992176 )
2018
8
Ocular Whipple Disease: Report of Three Cases. ( 30192690 )
2018
9
From Whipple Disease to Tropheryma whipplei Infection. ( 30351351 )
2018
10
Whipple disease after bariatric surgery: from malabsorption to malnutrition status. ( 30834767 )
2018
11
Cytology of cerebrospinal fluid in CNS Whipple disease. ( 28770535 )
2017
12
Genotypic analysis of Tropheryma whipplei from patients with Whipple disease in the Americas. ( 28385924 )
2017
13
Ultrastructural changes of small intestine in Whipple disease patient. ( 28230475 )
2017
14
A case of rapidly progressive dementia: Whipple disease of CNS. ( 29079886 )
2017
15
Whipple Disease ( 28722966 )
2017
16
Pseudo-Whipple Disease Cutaneous Lesions. ( 27097339 )
2016
17
Prosopagnosia as the Presenting Symptom of Whipple Disease. ( 27336807 )
2016
18
Deep Vein Thrombosis as Initial Manifestation of Whipple Disease. ( 27920655 )
2016
19
Whipple disease confined to the central nervous system presenting as a cystic tumor: Case report and review of literature. ( 27593833 )
2016
20
Primary Whipple disease of the brain: case report with long-term clinical and MRI follow-up. ( 26445540 )
2015
21
Gastrointestinal diagnosis of classical whipple disease: clinical, endoscopic, and histopathologic features in 191 patients. ( 25881849 )
2015
22
Atypical presentation of Whipple disease with no diarrhea. ( 26275278 )
2015
23
Specific cutaneous involvement in Whipple disease. ( 24562051 )
2014
24
Bilateral panuveitis associated with Whipple disease - case report. ( 27625936 )
2014
25
Primary Whipple disease of the CNS presenting with chorea and dystonia: A video case report. ( 29443151 )
2014
26
Pulmonary hypertension associated with Whipple disease. ( 25445953 )
2014
27
Neurocognitive impairment in Whipple disease with central nervous system involvement. ( 24674966 )
2014
28
Monoclonal B-cell lymphocyte proliferation in a patient presenting with historical Whipple disease. ( 23441662 )
2013
29
Rheumatic and musculoskeletal features of Whipple disease: a report of 29 cases. ( 24187107 )
2013
30
Oculomasticatory myorhythmia and agrypnia excitata guide the diagnosis of Whipple disease. ( 24210608 )
2013
31
Central nervous system involvement in Whipple disease: clinical study of 18 patients and long-term follow-up. ( 24145700 )
2013
32
A severe Whipple disease with an immune reconstitution inflammatory syndrome: An additional case of thalidomide efficiency. ( 24289960 )
2013
33
Whipple disease diagnosed with PCR using formalin-fixed paraffin-embedded specimens of the intestinal mucosa. ( 23318851 )
2013
34
Resolution of Whipple Disease-Induced Pulmonary Hypertension Following Antibiotic Therapy. ( 23344104 )
2013
35
Whipple disease revealed by lung involvement: a case report and literature review. ( 22670021 )
2012
36
Whipple disease mimicking adult-onset Still's disease and treated by anakinra: diagnosis using PCR. ( 22639877 )
2012
37
A unique posterior segment manifestation of whipple disease. ( 25390964 )
2012
38
Whipple disease a century after the initial description: increased recognition of unusual presentations, autoimmune comorbidities, and therapy effects. ( 22743287 )
2012
39
Isolated CNS Whipple disease with normal brain MRI and false-positive CSF 14-3-3 protein: a case report and review of the literature. ( 23170246 )
2012
40
Whipple disease with crystalline keratopathy and chronic uveitis. ( 22965603 )
2012
41
Connecting the dots: the many systemic manifestations of whipple disease. ( 22347837 )
2012
42
Treated Whipple disease with erythema nodosum leprosum-like lesions: cutaneous PAS-positive macrophages slowly decrease with time and are associated with lymphangiectases: a case report. ( 22123268 )
2012
43
Whipple disease research accelerates. ( 21628651 )
2011
44
Infection: How should classic Whipple disease be managed? ( 20442732 )
2010
45
The immune reconstitution inflammatory syndrome in whipple disease: a cohort study. ( 21135294 )
2010
46
Whipple disease. ( 20224490 )
2010
47
Intestinal Mycobacterium avium complex infection initially misdiagnosed and mistreated as Whipple disease. ( 20138615 )
2010
48
Whipple disease of the central nervous system: an unusual occurrence in association with acquired immune deficiency syndrome. ( 19612977 )
2010
49
MR imaging of central nervous system Whipple disease: a 15-year review. ( 20395395 )
2010
50
The amnesic syndrome of primary Whipple disease of the brain. ( 20299864 )
2010

Variations for Whipple Disease

Expression for Whipple Disease

Search GEO for disease gene expression data for Whipple Disease.

Pathways for Whipple Disease

Pathways related to Whipple Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.38 HLA-DQB1 HLA-DRB1 HSPD1
2 11.17 HLA-DQB1 HLA-DRB1
3 11.05 GRPEL1 HSPD1
4 10.99 HLA-DQB1 HLA-DRB1
5 10.96 CD58 HLA-DQB1 HLA-DRB1

GO Terms for Whipple Disease

Cellular components related to Whipple Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endocytic vesicle membrane GO:0030666 9.37 HLA-DQB1 HLA-DRB1
2 ER to Golgi transport vesicle membrane GO:0012507 9.32 HLA-DQB1 HLA-DRB1
3 transport vesicle membrane GO:0030658 9.26 HLA-DQB1 HLA-DRB1
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.16 HLA-DQB1 HLA-DRB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQB1 HLA-DRB1
6 MHC class II protein complex GO:0042613 8.62 HLA-DQB1 HLA-DRB1

Biological processes related to Whipple Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.54 HLA-DRB1 HSPD1 IL16
2 interferon-gamma-mediated signaling pathway GO:0060333 9.32 HLA-DQB1 HLA-DRB1
3 antigen processing and presentation GO:0019882 9.26 HLA-DQB1 HLA-DRB1
4 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.16 HLA-DQB1 HLA-DRB1
5 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
6 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Whipple Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Whipple Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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