Aliases & Classifications for Widow's Peak

MalaCards integrated aliases for Widow's Peak:

Name: Widow's Peak 58 30
Widow's Peak Syndrome 58 74
Widow's Peak, Ptosis, and Skeletal Anomalies 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
widow's peak:
Inheritance autosomal dominant inheritance

widow's peak syndrome:
Inheritance x-linked dominant inheritance


Classifications:



Summaries for Widow's Peak

MalaCards based summary : Widow's Peak, also known as widow's peak syndrome, is related to acromelic frontonasal dysostosis and frontonasal dysplasia 1. An important gene associated with Widow's Peak is ALX1 (ALX Homeobox 1). Related phenotypes are hypertelorism and low-set ears

Wikipedia : 77 A widow''s peak is a V-shaped point in the hairline in the center of the forehead. Hair growth on the... more...

Description from OMIM: 194000 314570

Related Diseases for Widow's Peak

Diseases related to Widow's Peak via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 acromelic frontonasal dysostosis 31.5 ALX3 ZSWIM6
2 frontonasal dysplasia 1 11.5
3 acrofacial dysostosis, catania type 11.4
4 hypertelorism, teebi type 11.4
5 aarskog-scott syndrome 11.4
6 cyprus facial neuromusculoskeletal syndrome 11.2
7 donnai-barrow syndrome 11.2
8 frontofacionasal dysplasia 11.2
9 frontonasal dysplasia 2 11.2
10 frontonasal dysplasia 3 11.2
11 hypertelorism 10.2
12 alopecia 10.2
13 ptosis 10.2
14 basal encephalocele 9.6 ALX3 ALX4
15 dysostosis 9.5 ALX4 ZSWIM6

Graphical network of the top 20 diseases related to Widow's Peak:



Diseases related to Widow's Peak

Symptoms & Phenotypes for Widow's Peak

Human phenotypes related to Widow's Peak:

33 (show all 19)
# Description HPO Frequency HPO Source Accession
1 hypertelorism 33 HP:0000316
2 low-set ears 33 HP:0000369
3 ptosis 33 HP:0000508
4 kyphosis 33 HP:0002808
5 inguinal hernia 33 HP:0000023
6 short stature 33 HP:0004322
7 cryptorchidism 33 HP:0000028
8 arthralgia/arthritis 33 HP:0005059
9 abnormality of the hand 33 HP:0001155
10 narrow iliac wings 33 HP:0002868
11 shawl scrotum 33 HP:0000049
12 recurrent patellar dislocation 33 HP:0005001
13 posteriorly rotated ears 33 HP:0000358
14 mild short stature 33 HP:0003502
15 widow's peak 33 HP:0000349
16 high iliac wings 33 HP:0008808
17 arthralgia of the hip 33 HP:0003365
18 hip osteoarthritis 33 HP:0008843
19 pointed frontal hairline 33 HP:0004544

Symptoms via clinical synopsis from OMIM:

58
Head And Neck Eyes:
hypertelorism

Skin Nails Hair Hair:
pointed frontal hairline

Clinical features from OMIM:

194000 314570

MGI Mouse Phenotypes related to Widow's Peak:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.71 ALX1 ALX3 ALX4 ZSWIM6
2 growth/size/body region MP:0005378 9.56 ALX1 ALX3 ALX4 ZSWIM6
3 craniofacial MP:0005382 9.54 ALX1 ALX3 ALX4
4 digestive/alimentary MP:0005381 9.5 ALX1 ALX3 ALX4
5 limbs/digits/tail MP:0005371 9.33 ALX1 ALX3 ALX4
6 nervous system MP:0003631 9.26 ALX1 ALX3 ALX4 ZSWIM6
7 respiratory system MP:0005388 8.8 ALX1 ALX3 ALX4

Drugs & Therapeutics for Widow's Peak

Search Clinical Trials , NIH Clinical Center for Widow's Peak

Genetic Tests for Widow's Peak

Genetic tests related to Widow's Peak:

# Genetic test Affiliating Genes
1 Widow's Peak 30

Anatomical Context for Widow's Peak

Publications for Widow's Peak

Articles related to Widow's Peak:

# Title Authors Year
1
Syndrome of short stature, widow's peak, ptosis, posteriorly angulated ears, and joint problems: exclusion of the Aarskog (FGD1) gene as a candidate gene. ( 11241498 )
2001
2
Widow's peak anomaly with alopecia. ( 3628586 )
1987
3
Widow's peak scalp-hair anomaly and its relation to ocular hypertelorism. ( 4128017 )
1973

Variations for Widow's Peak

Expression for Widow's Peak

Search GEO for disease gene expression data for Widow's Peak.

Pathways for Widow's Peak

GO Terms for Widow's Peak

Cellular components related to Widow's Peak according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.62 ALX1 ALX4

Biological processes related to Widow's Peak according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.63 ALX1 ALX3 ALX4
2 multicellular organism development GO:0007275 9.58 ALX1 ALX3 ALX4
3 regulation of apoptotic process GO:0042981 9.43 ALX3 ALX4
4 anterior/posterior pattern specification GO:0009952 9.37 ALX1 ALX4
5 roof of mouth development GO:0060021 9.32 ALX1 ALX4
6 pattern specification process GO:0007389 9.26 ALX3 ALX4
7 embryonic forelimb morphogenesis GO:0035115 9.16 ALX3 ALX4
8 embryonic hindlimb morphogenesis GO:0035116 8.96 ALX3 ALX4
9 embryonic skeletal system morphogenesis GO:0048704 8.8 ALX1 ALX3 ALX4

Molecular functions related to Widow's Peak according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.43 ALX1 ALX3 ALX4
2 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.16 ALX1 ALX4
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.96 ALX1 ALX4
4 sequence-specific DNA binding GO:0043565 8.8 ALX1 ALX3 ALX4

Sources for Widow's Peak

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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