SSA
MCID: WLD005
MIFTS: 32

Wild Type Attr Amyloidosis (SSA)

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Wild Type Attr Amyloidosis

MalaCards integrated aliases for Wild Type Attr Amyloidosis:

Name: Wild Type Attr Amyloidosis 58
Senile Systemic Amyloidosis 58 71
Wild Type Attr-Related Amyloidosis 58
Attrwt-Related Amyloidosis 58
Attrwt Amyloidosis 58
Ssa 58

Characteristics:

Orphanet epidemiological data:

58
wild type attr amyloidosis
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases


Summaries for Wild Type Attr Amyloidosis

MalaCards based summary : Wild Type Attr Amyloidosis, also known as senile systemic amyloidosis, is related to sessile serrated polyposis cancer syndrome and heart block, congenital. The drugs Doxycycline and Antiparasitic Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and liver, and related phenotypes are hypertrophic cardiomyopathy and congestive heart failure

Related Diseases for Wild Type Attr Amyloidosis

Diseases related to Wild Type Attr Amyloidosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 sessile serrated polyposis cancer syndrome 11.6
2 heart block, congenital 10.8
3 connective tissue disease 10.6
4 lupus erythematosus 10.6
5 systemic lupus erythematosus 10.6
6 atrioventricular block 10.6
7 cutaneous lupus erythematosus 10.5
8 neonatal lupus erythematosus 10.5
9 amyloidosis 10.5
10 subacute cutaneous lupus erythematosus 10.4
11 sjogren syndrome 10.4
12 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.4
13 endocardial fibroelastosis 10.4
14 exanthem 10.3
15 purpura 10.3
16 al amyloidosis 10.3
17 hereditary transthyretin amyloidosis 10.3
18 scleroderma, familial progressive 10.3
19 dermatomyositis 10.3
20 dilated cardiomyopathy 10.2
21 interstitial lung disease 10.2
22 vasculitis 10.2
23 annular erythema 10.2
24 mixed connective tissue disease 10.2
25 skin disease 10.2
26 polymyositis 10.2
27 undifferentiated connective tissue disease 10.2
28 discoid lupus erythematosus 10.2
29 congestive heart failure 10.2
30 amyloidosis, hereditary, transthyretin-related 10.2
31 atrial standstill 1 10.2
32 autoimmune disease 10.2
33 carpal tunnel syndrome 10.2
34 hydronephrosis 10.2
35 pyelonephritis 10.2
36 polyneuropathy 10.2
37 acute pyelonephritis 10.2
38 primary biliary cirrhosis 10.2
39 keratoconjunctivitis sicca 10.2
40 antiphospholipid syndrome 10.2
41 systemic scleroderma 10.2
42 adenoma 10.2
43 second-degree atrioventricular block 10.1
44 lymphopenia 10.1
45 myocarditis 10.1
46 lung disease 10.1
47 48,xyyy 10.1
48 raynaud phenomenon 10.1
49 hereditary amyloidosis 10.1
50 cardiogenic shock 10.1

Graphical network of the top 20 diseases related to Wild Type Attr Amyloidosis:



Diseases related to Wild Type Attr Amyloidosis

Symptoms & Phenotypes for Wild Type Attr Amyloidosis

Human phenotypes related to Wild Type Attr Amyloidosis:

58 31 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypertrophic cardiomyopathy 58 31 hallmark (90%) Very frequent (99-80%) HP:0001639
2 congestive heart failure 58 31 hallmark (90%) Very frequent (99-80%) HP:0001635
3 myocardial infarction 58 31 hallmark (90%) Very frequent (99-80%) HP:0001658
4 pedal edema 58 31 hallmark (90%) Very frequent (99-80%) HP:0010741
5 pleural effusion 58 31 hallmark (90%) Very frequent (99-80%) HP:0002202
6 interstitial pulmonary abnormality 58 31 hallmark (90%) Very frequent (99-80%) HP:0006530
7 pulmonary edema 58 31 hallmark (90%) Very frequent (99-80%) HP:0100598
8 abnormal ekg 58 31 hallmark (90%) Very frequent (99-80%) HP:0003115
9 hepatomegaly 58 31 frequent (33%) Frequent (79-30%) HP:0002240
10 bowel incontinence 58 31 frequent (33%) Frequent (79-30%) HP:0002607
11 chronic diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002028
12 intermittent diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002254
13 orthostatic hypotension due to autonomic dysfunction 58 31 frequent (33%) Frequent (79-30%) HP:0004926
14 gastrointestinal dysmotility 58 31 frequent (33%) Frequent (79-30%) HP:0002579
15 elevated alkaline phosphatase 58 31 frequent (33%) Frequent (79-30%) HP:0003155
16 autonomic bladder dysfunction 58 31 frequent (33%) Frequent (79-30%) HP:0005341
17 proteinuria 58 31 occasional (7.5%) Occasional (29-5%) HP:0000093
18 nephropathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0000112
19 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
20 weight loss 58 31 occasional (7.5%) Occasional (29-5%) HP:0001824
21 nephrotic syndrome 58 31 occasional (7.5%) Occasional (29-5%) HP:0000100
22 bradycardia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001662
23 arrhythmia 58 Frequent (79-30%)
24 autonomic dysregulation 58 Frequent (79-30%)

Drugs & Therapeutics for Wild Type Attr Amyloidosis

Drugs for Wild Type Attr Amyloidosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
2 Antiparasitic Agents Phase 2
3 Antiprotozoal Agents Phase 2
4 Anti-Bacterial Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Antimalarials Phase 2
7 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Doxycycline in Patients With Amyloidosis Completed NCT01677286 Phase 2 Doxycycline 100 mg po bid x 12 months
2 An 18 Month Open Label Study Of The Tolerability And Efficacy Of An Antisense Oligonucleotide In Patients With Wild-Type Transthyretin Amyloid Cardiomyopathy (Senile Systemic Amyloidosis) Withdrawn NCT02627820 Phase 2 Isis 420915/GSK 299872
3 A sTudy invesTigating the Role of Occult cArdiaC Amyloid in The Elderly With Aortic Stenosis Unknown status NCT03029026
4 Transthyretin Amyloidosis Outcomes Survey (THAOS): A Global, Multi-Center, Longitudinal, Observational Survey of Patients With Documented Transthyretin (TTR)Gene Mutations or Wild-Type ATTR Amyloidosis. Recruiting NCT00628745

Search NIH Clinical Center for Wild Type Attr Amyloidosis

Genetic Tests for Wild Type Attr Amyloidosis

Anatomical Context for Wild Type Attr Amyloidosis

MalaCards organs/tissues related to Wild Type Attr Amyloidosis:

40
Heart, Bone, Liver, Thyroid, Pituitary, Skin, Placenta

Publications for Wild Type Attr Amyloidosis

Articles related to Wild Type Attr Amyloidosis:

(show top 50) (show all 219)
# Title Authors PMID Year
1
Senile Systemic Amyloidosis Presenting as Hematuria: A Rare Presentation and Review of Literature. 61
31983923 2020
2
Lacrimal Gland Amyloidosis in an Elderly Patient. 61
32308610 2020
3
When and how do patients with cardiac amyloidosis die? 61
31134330 2020
4
Amyloidosis in Heart Failure. 61
31782077 2019
5
Tafamidis: a selective transthyretin stabilizer to treat wild-type ATTR amyloidosis and hereditary ATTR amyloidosis with cardiomyopathy. 61
31942875 2019
6
Wild-type ATTR amyloidosis may be associated with unexpected death among the elderly. 61
31731233 2019
7
Kinetic Transition in Amyloid Assembly as a Screening Assay for Oligomer-Selective Dyes. 61
31569739 2019
8
Diagnosis and treatment of heart failure in hereditary transthyretin amyloidosis. 61
31452023 2019
9
Transthyretin Amyloid Cardiomyopathy: JACC State-of-the-Art Review. 61
31171094 2019
10
Ultrastructure in Transthyretin Amyloidosis: From Pathophysiology to Therapeutic Insights. 61
30764529 2019
11
Echocardiographic and pathologic findings of wild-type transthyretin senile systemic amyloidosis developed in early 50s. 61
29700757 2018
12
Accelerated pre-senile systemic amyloidosis in PACAP knockout mice - a protective role of PACAP in age-related degenerative processes. 61
29774542 2018
13
A FTIR microspectroscopy study of the structural and biochemical perturbations induced by natively folded and aggregated transthyretin in HL-1 cardiomyocytes. 61
30131519 2018
14
First nationwide survey on systemic wild-type ATTR amyloidosis in Japan. 61
29182024 2018
15
Cardiac amyloidosis: An update on pathophysiology, diagnosis, and treatment. 61
28739313 2018
16
Safety and efficacy of a TTR specific antisense oligonucleotide in patients with transthyretin amyloid cardiomyopathy. 61
28906150 2017
17
Characterization of isolated amyloid myopathy. 61
28888072 2017
18
FRET studies of various conformational states adopted by transthyretin. 61
28478513 2017
19
Undiagnosed senile systemic amyloidosis with mesenteric angiopathy leading to fatal outcomes: Two case series with a review of literature. 61
28937388 2017
20
Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules. 61
28485623 2017
21
Senile Systemic Amyloidosis: An Underdiagnosed Disease. 61
30755970 2017
22
An Isolated Case of Late-onset Amyloidogenic Transthyretin Type Familial Amyloid Polyneuropathy Associated with a Mutant Transthyretin Substituting Methionine for Valine at Position 30 Showing Latent Progressive Cardiac Involvement Confirmed by Serial Annual Electrocardiograms. 61
28090046 2017
23
Acute cardiac failure secondary to senile systemic amyloidosis. 61
27103598 2016
24
Biochemical and Electrophysiological Modification of Amyloid Transthyretin on Cardiomyocytes. 61
27806283 2016
25
Rapid detection of wild-type and mutated transthyretins. 61
26342004 2016
26
The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies. 61
27012632 2016
27
Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer. 61
27093678 2016
28
Synthesis and structural analysis of halogen substituted fibril formation inhibitors of Human Transthyretin (TTR). 61
27067161 2016
29
Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity. 61
27050398 2016
30
(99m)Tc-DPD uptake reflects amyloid fibril composition in hereditary transthyretin amyloidosis. 61
26849806 2016
31
Transthyretin (ATTR) amyloidosis: clinical spectrum, molecular pathogenesis and disease-modifying treatments. 61
25604431 2015
32
Imaging of cardiac amyloidosis by (99m)Tc-PYP scintigraphy. 61
26665211 2015
33
The transthyretin amyloidoses: advances in therapy. 61
26048914 2015
34
A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model. 61
25694367 2015
35
Cardiac amyloidosis in a heart transplant patient - A case report and retrospective analysis of amyloidosis evolution. 61
25674390 2015
36
Wild-type ATTR amyloidosis of the ureter in a 56-year-old woman with rheumatoid arthritis and Sjögren's syndrome. 61
26339445 2015
37
[Amyloidosis and neurological disorders: Treatable amyloidosis]. 61
26458571 2015
38
The flavonoid luteolin, but not luteolin-7-O-glucoside, prevents a transthyretin mediated toxic response. 61
26020516 2015
39
Cooperative stabilization of transthyretin by clusterin and diflunisal. 61
25478940 2015
40
Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein. 61
25485123 2014
41
Inhibitory activities of propolis and its promising component, caffeic acid phenethyl ester, against amyloidogenesis of human transthyretin. 61
25314129 2014
42
The importance of a gatekeeper residue on the aggregation of transthyretin: implications for transthyretin-related amyloidoses. 61
25086037 2014
43
Novel styrylbenzene derivatives for detecting amyloid deposits. 61
24815035 2014
44
[Answer to the letter from Mrs Aurélie Daumas about our article "senile systemic amyloidosis: definition, diagnosis, why thinking about?"]. 61
24997877 2014
45
Transthyretin-derived amyloidosis: probably a common cause of lumbar spinal stenosis. 61
24620715 2014
46
Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation. 61
24023270 2014
47
[Familial amyloid polyneuropathy: clinicopathological aspects]. 61
24998820 2014
48
[Senile systemic amyloidosis]. 61
24998826 2014
49
Recent progress in the understanding and treatment of transthyretin amyloidosis. 61
24749898 2014
50
Left ventricular amyloid deposition in patients with heart failure and preserved ejection fraction. 61
24720917 2014

Variations for Wild Type Attr Amyloidosis

Expression for Wild Type Attr Amyloidosis

Search GEO for disease gene expression data for Wild Type Attr Amyloidosis.

Pathways for Wild Type Attr Amyloidosis

GO Terms for Wild Type Attr Amyloidosis

Sources for Wild Type Attr Amyloidosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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