MCID: WLM011
MIFTS: 38

Wilms Tumor 6

Categories: Genetic diseases, Nephrological diseases, Rare diseases, Cancer diseases, Fetal diseases

Aliases & Classifications for Wilms Tumor 6

MalaCards integrated aliases for Wilms Tumor 6:

Name: Wilms Tumor 6 57 75 6
Wilms Tumor 6, Susceptibility to 57 75
Wilms Tumor, Susceptibility to 57 75
Wt6 57 75
Susceptibility to Wilms Tumor 6 75
Nephroblastoma 73
Wilms Tumor 57

Classifications:



External Ids:

OMIM 57 616806
MeSH 44 D009396
SNOMED-CT via HPO 69 25081006 302849000

Summaries for Wilms Tumor 6

UniProtKB/Swiss-Prot : 75 Wilms tumor 6: A pediatric malignancy of kidney, and the most common childhood abdominal malignancy. It is caused by the uncontrolled multiplication of renal stem, stromal, and epithelial cells.

MalaCards based summary : Wilms Tumor 6, also known as wilms tumor 6, susceptibility to, is related to wilms tumor 1 and wilms tumor 5, and has symptoms including abdominal pain An important gene associated with Wilms Tumor 6 is REST (RE1 Silencing Transcription Factor). The drug Nitric Oxide has been mentioned in the context of this disorder. Affiliated tissues include kidney, myeloid and t cells, and related phenotype is nephroblastoma.

Description from OMIM: 616806

Related Diseases for Wilms Tumor 6

Diseases in the Hereditary Wilms' Tumor family:

Wilms Tumor 1 Wilms Tumor 2
Wilms Tumor 3 Wilms Tumor 4
Wilms Tumor 5 Wilms Tumor 6
Familial Wilms Tumor 2

Diseases related to Wilms Tumor 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 271)
# Related Disease Score Top Affiliating Genes
1 wilms tumor 1 12.6
2 wilms tumor 5 12.6
3 wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 12.5
4 cervical wilms' tumor 12.2
5 wilms tumor 2 12.2
6 perlman syndrome 12.2
7 denys-drash syndrome 12.1
8 wilms tumor 4 12.1
9 wilms tumor and radial bilateral aplasia 12.1
10 wilms tumor, aniridia, genitourinary anomalies, mental retardation, and obesity syndrome 12.1
11 wilms tumor predisposition 12.1
12 wilms tumor 3 12.1
13 hereditary wilms' tumor 12.1
14 epithelial predominant wilms' tumor 12.1
15 mixed cell type kidney wilms' tumor 12.0
16 blastema predominant kidney wilms' tumor 12.0
17 stromal predominant kidney wilms' tumor 12.0
18 metachronous kidney wilms' tumor 12.0
19 familial wilms tumor 2 12.0
20 global developmental delay-lung cysts-overgrowth-wilms tumor syndrome 11.9
21 frasier syndrome 11.5
22 beckwith-wiedemann syndrome 11.4
23 mulibrey nanism 11.4
24 aniridia 1 11.3
25 hemihyperplasia, isolated 11.2
26 mosaic variegated aneuploidy syndrome 1 11.1
27 mosaic variegated aneuploidy syndrome 3 11.1
28 ovarian wilms' cancer 10.9
29 hyperparathyroidism 2 with jaw tumors 10.9
30 li-fraumeni syndrome 10.9
31 li-fraumeni syndrome 2 10.9
32 rhabdoid tumor predisposition syndrome 1 10.9
33 mosaic variegated aneuploidy syndrome 2 10.9
34 thauvin-robinet-faivre syndrome 10.9
35 simpson-golabi-behmel syndrome 10.9
36 leukemia 10.6
37 myeloid leukemia 10.4
38 leukemia, acute myeloid 10.4
39 renal oncocytoma 10.3
40 sarcoma 10.2
41 breast cancer 10.2
42 horseshoe kidney 10.2
43 acute leukemia 10.1
44 lymphoblastic leukemia 10.1
45 leukemia, acute lymphoblastic 10.1
46 renal cell carcinoma, nonpapillary 10.1
47 myelodysplastic syndrome 10.1
48 neuroblastoma 10.1
49 pseudohermaphroditism 10.1
50 clear cell sarcoma 10.1

Graphical network of the top 20 diseases related to Wilms Tumor 6:



Diseases related to Wilms Tumor 6

Symptoms & Phenotypes for Wilms Tumor 6

Clinical features from OMIM:

616806

Human phenotypes related to Wilms Tumor 6:

32
# Description HPO Frequency HPO Source Accession
1 nephroblastoma 32 HP:0002667

UMLS symptoms related to Wilms Tumor 6:


abdominal pain

Drugs & Therapeutics for Wilms Tumor 6

Drugs for Wilms Tumor 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved 10102-43-9 145068 160954

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acute Effect of Continuous Positive Airway Pressure in Heart Failure Completed NCT01088854 Phase 2
2 Study in Children With the Diagnosis of Congenital Diaphragmatic Hernia (CDH) and Oesophageal Atresia (EA) Completed NCT02466451

Search NIH Clinical Center for Wilms Tumor 6

Genetic Tests for Wilms Tumor 6

Anatomical Context for Wilms Tumor 6

MalaCards organs/tissues related to Wilms Tumor 6:

41
Kidney, Myeloid, T Cells, Bone, Heart, Lung, Ovary

Publications for Wilms Tumor 6

Articles related to Wilms Tumor 6:

(show top 50) (show all 1513)
# Title Authors Year
1
Loss of Wilms tumor 1 protein is a marker for apoptosis in response to replicative stress in leukemic cells. ( 29589053 )
2018
2
Wilms' tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability. ( 29482572 )
2018
3
Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia. ( 29445571 )
2018
4
Wilms' Tumor 1 Overexpression in Granulosa Cells Is Associated with Polycystic Ovaries in Polycystic Ovary Syndrome Patients. ( 29414825 )
2018
5
Quantification of Wilms' tumor 1 mRNA by digital polymerase chain reaction. ( 28994041 )
2018
6
Sensitive detection of rare antigen-specific T cells directed against Wilms' tumor 1 by FluoroSpot assay. ( 28573960 )
2018
7
Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus-Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination. ( 29253144 )
2018
8
Outcomes of measurable residual disease in pediatric acute myeloid leukemia pre- and post-hematopoietic stem cell transplant: validation of difference from normal flow cytometry with chimerism studies and Wilms tumor 1 gene expression. ( 29933069 )
2018
9
Simultaneous Presentation of Wilms' Tumor and Contralateral Ganglioneuroma in a Child: Case Report and Literature Review. ( 29334535 )
2018
10
Wilms' Tumor 1 Gene Expression Using a Standardized European LeukemiaNet-Certified Assay Compared to Other Methods for Detection of Minimal Residual Disease in Myelodysplastic Syndrome and Acute Myelogenous Leukemia after Allogeneic Blood Stem Cell Transplantation. ( 29753838 )
2018
11
Description of mutation spectrum and polymorphism of Wilms' tumor 1 (WT1) gene in hypospadias patients in the Indonesian population. ( 29958641 )
2018
12
Diagnosis of Beckwith-Wiedemann syndrome in children presenting with Wilms tumor. ( 29932284 )
2018
13
Urine cell-free DNA is a biomarker for nephroblastomatosis or Wilms tumor in PIK3CA-related overgrowth spectrum (PROS). ( 29300373 )
2018
14
Clinicopathological parameters and prognostic relevance of miR-21 and PTEN expression in Wilms' tumor. ( 28040201 )
2017
15
Development of oral cancer vaccine using recombinant Bifidobacterium displaying Wilms' tumor 1 protein. ( 28299466 )
2017
16
Inhibitory effect of Par-4 combined with cisplatin on human Wilms' tumor cells. ( 28720068 )
2017
17
Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation. ( 28553959 )
2017
18
Impact of Wilms' tumor 1 expression on outcome of patients undergoing allogeneic stem cell transplantation for AML. ( 28067876 )
2017
19
Functional KRAS mutations and a potential role for PI3K/AKT activation in Wilms tumors. ( 28188683 )
2017
20
Glypican-3 mRNA expression level in Wilms tumor: correlation with histological type, stage, and outcome. ( 28432433 )
2017
21
Wilms Tumor Treatment Outcomes: Perspectives From a Low-Income Setting. ( 29094095 )
2017
22
Encephalocraniocutaneous lipomatosis with Wilms' tumor. ( 28612492 )
2017
23
The Wilms tumor protein Wt1 contributes to female fertility by regulating oviductal proteostasis. ( 28334862 )
2017
24
Over-Expression of miR-21 and Lower PTEN Levels in Wilms' Tumor with Aggressive Behavior. ( 28529243 )
2017
25
Cancer antigen profiling for malignant pleural mesothelioma immunotherapy: expression and coexpression of mesothelin, cancer antigen 125, and Wilms tumor 1. ( 29100432 )
2017
26
Effects of MicroRNA-19b on the Proliferation, Apoptosis, and Migration of Wilms' Tumor Cells Via the PTEN/PI3K/AKT Signaling Pathway. ( 28322459 )
2017
27
Turning back the Wheel: Inducing Mesenchymal to Epithelial Transition via Wilms Tumor 1 Knockdown in Human Mesothelioma Cell Lines to Influence Proliferation, Invasiveness, and Chemotaxis. ( 28054314 )
2017
28
Significance of Wilms' tumor 1 antigen as a cancer vaccine for pancreatic cancer. ( 28950074 )
2017
29
Wilms Tumor 1 gene expression levels improve risk stratification in AML patients. Results of a multicentre study within the Spanish Group for Molecular Biology in Haematology. ( 28369773 )
2017
30
Wilms Tumor 1 (WT1) mRNA Expression Level at Diagnosis Is a Significant Prognostic Marker in Elderly Patients with Myelodysplastic Syndrome. ( 27866185 )
2017
31
Simultaneous Presentation of Wilms Tumor and Immature Ovarian Teratoma in Beckwith-Wiedemann Syndrome. ( 28692553 )
2017
32
Differential detection of cytoplasmic Wilms tumor 1 expression by immunohistochemistry, western blotting and mRNA quantification. ( 27922671 )
2017
33
Surveillance Recommendations for Children with Overgrowth Syndromes and Predisposition to Wilms Tumors and Hepatoblastoma. ( 28674120 )
2017
34
Association Between HACE1 Gene Polymorphisms and Wilms' Tumor Risk in a Chinese Population. ( 29243987 )
2017
35
Sonographic screening for Wilms tumor in children with CLOVES syndrome. ( 28627003 )
2017
36
Nucleotide Transition 390C-T in the Wilms' Tumor 1 Gene: A Risk Factor of Hypospadias? ( 28878596 )
2017
37
Osteopathia striata with cranial sclerosis and Wilms tumor: Coincidence or consequence? ( 29120061 )
2017
38
Transcription factor Wilms' tumor 1 regulates developmental RNAs through 3' UTR interaction. ( 28289143 )
2017
39
Quantitative assessment of Wilms tumor 1 expression by real-time quantitative polymerase chain reaction in patients with acute myeloblastic leukemia. ( 28567073 )
2017
40
Use of Wilms Tumor 1 Gene Expression as a Reliable Marker for Prognosis and Minimal Residual Disease Monitoring in Acute Myeloid Leukemia With Normal Karyotype Patients. ( 28163010 )
2017
41
Pencil beam scanning proton therapy for treatment of the retroperitoneum after nephrectomy for Wilms tumor: A dosimetric comparison study. ( 27565764 )
2017
42
Truncating Wilms Tumor Suppressor Gene 1 Mutation in an XX Female with Adult-Onset Focal Segmental Glomerulosclerosis and Streak Ovaries: A Case Report. ( 27701157 )
2017
43
Molecular cloning of canine Wilms' tumor 1 for immunohistochemical analysis in canine tissues. ( 28603218 )
2017
44
Wilms' tumor gene 1 silencing inhibits proliferation of human osteosarcoma MG-63 cell line by cell cycle arrest and apoptosis activation. ( 28107196 )
2017
45
Association between<i>TP53</i>gene Arg72Pro polymorphism and Wilms' tumor risk in a Chinese population. ( 28260929 )
2017
46
Clinical Utility of Wilms' Tumor 1 Monitoring in Patients with Myeloid Malignancy and Prior Allogeneic Hematopoietic Stem Cell Transplantation. ( 28673850 )
2017
47
Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells. ( 27889611 )
2017
48
Palliative radiation therapy for superior vena cava syndrome in metastatic Wilms tumor using 10XFFF and 3D surface imaging to avoid anesthesia in a pediatric patient-a teaching case. ( 28740919 )
2017
49
Activation of the Wnt/I^-catenin pathway is common in wilms tumor, but rarely through I^-catenin mutation and APC promoter methylation. ( 27679509 )
2016
50
Is Nephron Sparing Surgery Justified in Wilms Tumor With Beckwith-Wiedemann Syndrome or Isolated Hemihypertrophy? ( 27228957 )
2016

Variations for Wilms Tumor 6

UniProtKB/Swiss-Prot genetic disease variations for Wilms Tumor 6:

75
# Symbol AA change Variation ID SNP ID
1 REST p.Arg160Pro VAR_076333
2 REST p.Asn290Tyr VAR_076334
3 REST p.His322Arg VAR_076335 rs869025312
4 REST p.His412Gln VAR_076336

ClinVar genetic disease variations for Wilms Tumor 6:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 REST NM_005612.4(REST): c.831_832delAT (p.Cys278Trpfs) deletion risk factor rs869025310 GRCh38 Chromosome 4, 56911469: 56911470
2 REST NM_005612.4(REST): c.831_832delAT (p.Cys278Trpfs) deletion risk factor rs869025310 GRCh37 Chromosome 4, 57777635: 57777636
3 REST NM_005612.4(REST): c.773_776delTGAG (p.Val258Alafs) deletion risk factor rs869025311 GRCh38 Chromosome 4, 56911411: 56911414
4 REST NM_005612.4(REST): c.773_776delTGAG (p.Val258Alafs) deletion risk factor rs869025311 GRCh37 Chromosome 4, 57777577: 57777580
5 REST NM_005612.4(REST): c.965A> G (p.His322Arg) single nucleotide variant risk factor rs869025312 GRCh38 Chromosome 4, 56919853: 56919853
6 REST NM_005612.4(REST): c.965A> G (p.His322Arg) single nucleotide variant risk factor rs869025312 GRCh37 Chromosome 4, 57786019: 57786019

Expression for Wilms Tumor 6

Search GEO for disease gene expression data for Wilms Tumor 6.

Pathways for Wilms Tumor 6

GO Terms for Wilms Tumor 6

Sources for Wilms Tumor 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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