WT6
MCID: WLM011
MIFTS: 40

Wilms Tumor 6 (WT6)

Categories: Cancer diseases, Fetal diseases, Genetic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Wilms Tumor 6

MalaCards integrated aliases for Wilms Tumor 6:

Name: Wilms Tumor 6 58 76 30 6
Wilms Tumor 6, Susceptibility to 58 76
Wilms Tumor, Susceptibility to 58 76
Wt6 58 76
Susceptibility to Wilms Tumor 6 76
Nephroblastoma 74
Wilms Tumor 58

Classifications:



External Ids:

OMIM 58 616806
MeSH 45 D009396
SNOMED-CT via HPO 70 25081006 302849000
UMLS 74 C0027708

Summaries for Wilms Tumor 6

UniProtKB/Swiss-Prot : 76 Wilms tumor 6: A pediatric malignancy of kidney, and the most common childhood abdominal malignancy. It is caused by the uncontrolled multiplication of renal stem, stromal, and epithelial cells.

MalaCards based summary : Wilms Tumor 6, also known as wilms tumor 6, susceptibility to, is related to wilms tumor 1 and wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome, and has symptoms including abdominal pain An important gene associated with Wilms Tumor 6 is REST (RE1 Silencing Transcription Factor). The drug Nitric Oxide has been mentioned in the context of this disorder. Affiliated tissues include kidney, myeloid and t cells, and related phenotype is nephroblastoma.

Description from OMIM: 616806

Related Diseases for Wilms Tumor 6

Diseases in the Hereditary Wilms' Tumor family:

Wilms Tumor 1 Wilms Tumor 2
Wilms Tumor 3 Wilms Tumor 4
Wilms Tumor 5 Wilms Tumor 6
Familial Wilms Tumor 2

Diseases related to Wilms Tumor 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 350)
# Related Disease Score Top Affiliating Genes
1 wilms tumor 1 12.8
2 wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 12.7
3 cervical wilms' tumor 12.4
4 wilms tumor 2 12.4
5 wilms tumor 4 12.4
6 perlman syndrome 12.3
7 denys-drash syndrome 12.3
8 wilms tumor and radial bilateral aplasia 12.3
9 wilms tumor predisposition 12.3
10 wilms tumor, aniridia, genitourinary anomalies, mental retardation, and obesity syndrome 12.3
11 wilms tumor 3 12.2
12 hereditary wilms' tumor 12.2
13 epithelial predominant wilms' tumor 12.2
14 stromal predominant kidney wilms' tumor 12.2
15 global developmental delay, lung cysts, overgrowth, and wilms tumor 12.2
16 mixed cell type kidney wilms' tumor 12.2
17 blastema predominant kidney wilms' tumor 12.2
18 metachronous kidney wilms' tumor 12.2
19 familial wilms tumor 2 12.2
20 frasier syndrome 11.7
21 beckwith-wiedemann syndrome 11.6
22 mulibrey nanism 11.6
23 aniridia 1 11.5
24 hemihyperplasia, isolated 11.4
25 ovarian wilms' cancer 11.4
26 wilms tumor 5 11.3
27 mosaic variegated aneuploidy syndrome 1 11.3
28 mosaic variegated aneuploidy syndrome 3 11.3
29 hyperparathyroidism 2 with jaw tumors 11.1
30 li-fraumeni syndrome 11.1
31 li-fraumeni syndrome 2 11.1
32 rhabdoid tumor predisposition syndrome 1 11.1
33 mosaic variegated aneuploidy syndrome 2 11.1
34 thauvin-robinet-faivre syndrome 11.1
35 simpson-golabi-behmel syndrome 11.1
36 leukemia 10.8
37 neuroblastoma 10.6
38 myeloid leukemia 10.6
39 leukemia, acute myeloid 10.5
40 renal oncocytoma 10.5
41 breast cancer 10.4
42 sarcoma 10.4
43 lymphocytic leukemia 10.4
44 leukemia, acute lymphoblastic 10.4
45 horseshoe kidney 10.4
46 renal cell carcinoma, nonpapillary 10.3
47 acute leukemia 10.3
48 adenocarcinoma 10.3
49 rhabdomyosarcoma 10.3
50 pseudohermaphroditism 10.3

Graphical network of the top 20 diseases related to Wilms Tumor 6:



Diseases related to Wilms Tumor 6

Symptoms & Phenotypes for Wilms Tumor 6

Human phenotypes related to Wilms Tumor 6:

33
# Description HPO Frequency HPO Source Accession
1 nephroblastoma 33 HP:0002667

Clinical features from OMIM:

616806

UMLS symptoms related to Wilms Tumor 6:


abdominal pain

Drugs & Therapeutics for Wilms Tumor 6

Drugs for Wilms Tumor 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved 10102-43-9 145068

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acute Effect of Continuous Positive Airway Pressure in Heart Failure Completed NCT01088854 Phase 2
2 Study in Children With the Diagnosis of Congenital Diaphragmatic Hernia (CDH) and Oesophageal Atresia (EA) Completed NCT02466451

Search NIH Clinical Center for Wilms Tumor 6

Genetic Tests for Wilms Tumor 6

Genetic tests related to Wilms Tumor 6:

# Genetic test Affiliating Genes
1 Wilms Tumor 6 30 REST

Anatomical Context for Wilms Tumor 6

MalaCards organs/tissues related to Wilms Tumor 6:

42
Kidney, Myeloid, T Cells, Bone, Ovary, Brain, Lymph Node

Publications for Wilms Tumor 6

Articles related to Wilms Tumor 6:

(show top 50) (show all 3040)
# Title Authors Year
1
Lessons from a patient with cardiac arrest due to massive pulmonary embolism as the initial presentation of Wilms tumor: a case report and literature review. ( 30704433 )
2019
2
Impact of cyclophosphamide and etoposide on outcome of clear cell sarcoma of the kidney treated on the National Wilms Tumor Study-5 (NWTS-5). ( 30255545 )
2019
3
The Rare Association of Cleft Lip and/or Palate and Wilms Tumor. ( 30712371 )
2019
4
What should we tackle next in acute myeloid leukemia? Wilms tumor gene 1 vaccine therapy would be a promising and versatile strategy for acute myeloid leukemia. ( 30882253 )
2019
5
Measurable residual disease monitoring using Wilms tumor gene 1 expression in childhood acute myeloid leukemia based on child-specific reference values. ( 30900388 )
2019
6
Physiological functions of Wilms' tumor 1-associating protein and its role in tumourigenesis. ( 30756410 )
2019
7
The cell tube block technique and an immunohistochemistry panel including Wilms tumor 1 to assist in diagnosing cavitary effusions in dogs and cats. ( 30865320 )
2019
8
Phase I/II clinical trial of a Wilms' tumor 1-targeted dendritic cell vaccination-based immunotherapy in patients with advanced cancer. ( 30306202 )
2019
9
Wilms Tumor-1 (WT1) rs16754 Polymorphism ( 30520285 )
2019
10
Inhibition of Heme Oxygenase-1 Activity Enhances Wilms Tumor-1-Specific T-Cell Responses in Cancer Immunotherapy. ( 30678050 )
2019
11
Wilms tumor 1 expression: addressing the 'elephant' in MDS. ( 30714447 )
2019
12
The coexistence of a Wilms' tumor and renal cell carcinoma in children: a case report and review of the literature. ( 30774381 )
2019
13
Synchronous Bilateral Wilms Tumor: Five-Year Single-Center Experience with Assessment of Quality of Life. ( 30686888 )
2019
14
TRIM28 haploinsufficiency predisposes to Wilms tumor. ( 30694527 )
2019
15
Determining the optimal cutoff point for lymph node density and its impact on overall survival in children with Wilms' tumor. ( 30697068 )
2019
16
Educational Case: Wilms Tumor (Nephroblastoma). ( 30733996 )
2019
17
Botryoid Wilms Tumor: A Rare Diagnosis With An Atypical Presentation. ( 30735745 )
2019
18
The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair. ( 30763305 )
2019
19
Agreement between clinicoradiological signs at diagnosis and radiohistological analysis after neoadjuvant chemotherapy of suspected Wilms tumor rupture: Consequences on therapeutic choices. ( 30773805 )
2019
20
MiR-155-5p affects Wilms' tumor cell proliferation and apoptosis via targeting CREB1. ( 30779069 )
2019
21
Intracardiac Extension of Wilms Tumor: A Case of a 2.5-Year-Old Girl Presenting with Upper Venous Congestion Caused by Tumor Growth into the Right Cardiac Ventricle. ( 30792643 )
2019
22
miR-483-5p Targets MKNK1 to Suppress Wilms' Tumor Cell Proliferation and Apoptosis In Vitro and In Vivo. ( 30798328 )
2019
23
The Natural History of Wilms Tumor - A Case Comparison of Two Different Tumors. ( 30807774 )
2019
24
Salidroside inhibits the growth, migration and invasion of Wilms' tumor cells through down-regulation of miR-891b. ( 30822424 )
2019
25
A1CF-Axin2 signal axis regulates apoptosis and migration in Wilms tumor-derived cells through Wnt/β-catenin pathway. ( 30825095 )
2019
26
Curcumin suppresses wilms' tumor metastasis by inhibiting RECK methylation. ( 30841433 )
2019
27
Association of KRAS and NRAS gene polymorphisms with Wilms tumor risk: a four-center case-control study. ( 30860980 )
2019
28
miR-140-5p alleviates the aggressive progression of Wilms' tumor through directly targeting TGFBR1 gene. ( 30863174 )
2019
29
PAI-1 and protein C as early markers of veno-occlusive disease in patients treated for Wilms tumor. ( 30865371 )
2019
30
Clinical Diagnosis Value of Chest X-Ray and Ultrasound in Recurrence in Patients With Favorable-Histology Wilms Tumor. ( 30875279 )
2019
31
FXR1 expression domain in Wilms tumor. ( 30894247 )
2019
32
Rare clinical condition during Wilms' tumor treatment: Testicular metastasis. ( 30916857 )
2019
33
Autophagy related markers (Beclin-1 and ATG4B) are strongly expressed in Wilms' tumor and correlate with favorable histology. ( 29989143 )
2019
34
Continuing barriers to care of Wilms tumor in a low-income country. ( 30152039 )
2019
35
Outcome of Wilms tumor patients with bone metastasis enrolled on National Wilms Tumor Studies 1-5: A report from the Children's Oncology Group. ( 30160355 )
2019
36
Paternally inherited WT1 mutation plus uniparental disomy of 11p may be an essential mechanism for development of WT1-mutated familial Wilms tumor. ( 30221469 )
2019
37
Fetal programming and Wilms tumor. ( 30255546 )
2019
38
Maintenance chemotherapy to reduce the risk of a metachronous Wilms tumor in children with bilateral nephroblastomatosis. ( 30334607 )
2019
39
Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation. ( 30367465 )
2019
40
The effect of preoperative chemotherapy on histological subtyping and staging of Wilms tumors: The United Kingdom Children's Cancer Study Group (UKCCSG) Wilms tumor trial 3 (UKW3) experience. ( 30408319 )
2019
41
Botryoid Wilms tumor: a non-existent "entity" causing diagnostic and staging difficulties. ( 30515564 )
2019
42
Retraction of: Long Noncoding RNA SOX2OT Accelerates the Carcinogenesis of Wilms' Tumor Through ceRNA Through miR-363/FOXP4 Axis, by Ma L, Sun X, Kuai W, Hu J, Yuan Y, Feng W, and Lu X. DNA Cell Biol [Epub ahead of print]; DOI: 10.1089/dna.2018.4420, 2018. ( 30576227 )
2019
43
Pharmacotherapeutic Management of Wilms Tumor: An Update. ( 30604241 )
2019
44
TP53 rs1042522 C>G polymorphism and Wilms tumor susceptibility in Chinese children: a four-center case-control study. ( 30610160 )
2019
45
A Case of Primary Paratesticular Wilms Tumor in an Undescended Testis. ( 30610907 )
2019
46
Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms' Tumor Suppressor Wt1. ( 30641926 )
2019
47
Immunohistochemical analysis of cyclin A expression in Wilms tumor. ( 30648000 )
2019
48
The Wilms tumor gene (WT1) (+ / - KTS) isoforms regulate steroidogenesis by modulating the PI3K/AKT and ERK1/2 pathways in bovine granulosa cells. ( 30649196 )
2019
49
Weighted gene co‑expression network analysis for identifying hub genes in association with prognosis in Wilms tumor. ( 30664180 )
2019
50
Correlations between Histological and Array Comparative Genomic Hybridization Characterizations of Wilms Tumor. ( 30671724 )
2019

Variations for Wilms Tumor 6

UniProtKB/Swiss-Prot genetic disease variations for Wilms Tumor 6:

76
# Symbol AA change Variation ID SNP ID
1 REST p.Arg160Pro VAR_076333
2 REST p.Asn290Tyr VAR_076334
3 REST p.His322Arg VAR_076335 rs869025312
4 REST p.His412Gln VAR_076336

ClinVar genetic disease variations for Wilms Tumor 6:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 REST NM_005612.4(REST): c.831_832delAT (p.Cys278Trpfs) deletion risk factor rs869025310 GRCh38 Chromosome 4, 56911469: 56911470
2 REST NM_005612.4(REST): c.831_832delAT (p.Cys278Trpfs) deletion risk factor rs869025310 GRCh37 Chromosome 4, 57777635: 57777636
3 REST NM_005612.4(REST): c.773_776delTGAG (p.Val258Alafs) deletion risk factor rs869025311 GRCh38 Chromosome 4, 56911411: 56911414
4 REST NM_005612.4(REST): c.773_776delTGAG (p.Val258Alafs) deletion risk factor rs869025311 GRCh37 Chromosome 4, 57777577: 57777580
5 REST NM_005612.4(REST): c.965A> G (p.His322Arg) single nucleotide variant risk factor rs869025312 GRCh38 Chromosome 4, 56919853: 56919853
6 REST NM_005612.4(REST): c.965A> G (p.His322Arg) single nucleotide variant risk factor rs869025312 GRCh37 Chromosome 4, 57786019: 57786019

Expression for Wilms Tumor 6

Search GEO for disease gene expression data for Wilms Tumor 6.

Pathways for Wilms Tumor 6

GO Terms for Wilms Tumor 6

Sources for Wilms Tumor 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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