WT6
MCID: WLM011
MIFTS: 40

Wilms Tumor 6 (WT6)

Categories: Cancer diseases, Fetal diseases, Genetic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Wilms Tumor 6

MalaCards integrated aliases for Wilms Tumor 6:

Name: Wilms Tumor 6 58 76 30 6
Wilms Tumor 6, Susceptibility to 58 76
Wilms Tumor, Susceptibility to 58 76
Wt6 58 76
Susceptibility to Wilms Tumor 6 76
Nephroblastoma 74
Wilms Tumor 58

Classifications:



External Ids:

OMIM 58 616806
MeSH 45 D009396
SNOMED-CT via HPO 70 25081006 302849000
UMLS 74 C0027708

Summaries for Wilms Tumor 6

UniProtKB/Swiss-Prot : 76 Wilms tumor 6: A pediatric malignancy of kidney, and the most common childhood abdominal malignancy. It is caused by the uncontrolled multiplication of renal stem, stromal, and epithelial cells.

MalaCards based summary : Wilms Tumor 6, also known as wilms tumor 6, susceptibility to, is related to wilms tumor 1 and wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome, and has symptoms including abdominal pain An important gene associated with Wilms Tumor 6 is REST (RE1 Silencing Transcription Factor). The drug Nitric Oxide has been mentioned in the context of this disorder. Affiliated tissues include kidney, myeloid and t cells, and related phenotype is nephroblastoma.

Description from OMIM: 616806

Related Diseases for Wilms Tumor 6

Diseases in the Hereditary Wilms' Tumor family:

Wilms Tumor 1 Wilms Tumor 2
Wilms Tumor 3 Wilms Tumor 4
Wilms Tumor 5 Wilms Tumor 6
Familial Wilms Tumor 2

Diseases related to Wilms Tumor 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 379)
# Related Disease Score Top Affiliating Genes
1 wilms tumor 1 12.8
2 wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 12.7
3 global developmental delay, lung cysts, overgrowth, and wilms tumor 12.5
4 cervical wilms' tumor 12.5
5 wilms tumor 2 12.4
6 wilms tumor and radial bilateral aplasia 12.4
7 wilms tumor 4 12.4
8 perlman syndrome 12.3
9 denys-drash syndrome 12.3
10 wilms tumor, aniridia, genitourinary anomalies, mental retardation, and obesity syndrome 12.3
11 wilms tumor predisposition 12.3
12 hereditary wilms' tumor 12.2
13 epithelial predominant wilms' tumor 12.2
14 stromal predominant kidney wilms' tumor 12.2
15 wilms tumor 3 12.2
16 mixed cell type kidney wilms' tumor 12.2
17 blastema predominant kidney wilms' tumor 12.2
18 metachronous kidney wilms' tumor 12.2
19 familial wilms tumor 2 12.2
20 frasier syndrome 11.7
21 beckwith-wiedemann syndrome 11.6
22 mulibrey nanism 11.6
23 mosaic variegated aneuploidy syndrome 3 11.6
24 aniridia 1 11.5
25 hemihyperplasia, isolated 11.5
26 ovarian wilms' cancer 11.4
27 thauvin-robinet-faivre syndrome 11.4
28 wilms tumor 5 11.3
29 mosaic variegated aneuploidy syndrome 1 11.3
30 hyperparathyroidism 2 with jaw tumors 11.1
31 li-fraumeni syndrome 11.1
32 li-fraumeni syndrome 2 11.1
33 rhabdoid tumor predisposition syndrome 1 11.1
34 mosaic variegated aneuploidy syndrome 2 11.1
35 simpson-golabi-behmel syndrome 11.1
36 leukemia 10.8
37 myeloid leukemia 10.6
38 leukemia, acute myeloid 10.5
39 renal oncocytoma 10.5
40 breast cancer 10.4
41 sarcoma 10.4
42 lymphocytic leukemia 10.4
43 leukemia, acute lymphoblastic 10.4
44 horseshoe kidney 10.4
45 renal cell carcinoma, nonpapillary 10.3
46 neuroblastoma 1 10.3
47 myelodysplastic syndrome 10.3
48 adenocarcinoma 10.3
49 rhabdomyosarcoma 10.3
50 acute leukemia 10.3

Graphical network of the top 20 diseases related to Wilms Tumor 6:



Diseases related to Wilms Tumor 6

Symptoms & Phenotypes for Wilms Tumor 6

Human phenotypes related to Wilms Tumor 6:

33
# Description HPO Frequency HPO Source Accession
1 nephroblastoma 33 HP:0002667

Clinical features from OMIM:

616806

UMLS symptoms related to Wilms Tumor 6:


abdominal pain

Drugs & Therapeutics for Wilms Tumor 6

Drugs for Wilms Tumor 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved 10102-43-9 145068

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acute Effect of Continuous Positive Airway Pressure in Heart Failure Completed NCT01088854 Phase 2
2 Study in Children With the Diagnosis of Congenital Diaphragmatic Hernia (CDH) and Oesophageal Atresia (EA) Completed NCT02466451

Search NIH Clinical Center for Wilms Tumor 6

Genetic Tests for Wilms Tumor 6

Genetic tests related to Wilms Tumor 6:

# Genetic test Affiliating Genes
1 Wilms Tumor 6 30 REST

Anatomical Context for Wilms Tumor 6

MalaCards organs/tissues related to Wilms Tumor 6:

42
Kidney, Myeloid, T Cells, Ovary, Brain, Lymph Node, Spinal Cord

Publications for Wilms Tumor 6

Articles related to Wilms Tumor 6:

(show top 50) (show all 3054)
# Title Authors Year
1
Lessons from a patient with cardiac arrest due to massive pulmonary embolism as the initial presentation of Wilms tumor: a case report and literature review. ( 30704433 )
2019
2
Measurable residual disease monitoring using Wilms tumor gene 1 expression in childhood acute myeloid leukemia based on child-specific reference values. ( 30900388 )
2019
3
Impact of cyclophosphamide and etoposide on outcome of clear cell sarcoma of the kidney treated on the National Wilms Tumor Study-5 (NWTS-5). ( 30255545 )
2019
4
The Rare Association of Cleft Lip and/or Palate and Wilms Tumor. ( 30712371 )
2019
5
Differential Expression of Wilms' Tumor Protein in Diffuse Intrinsic Pontine Glioma. ( 30990879 )
2019
6
A phase I clinical study of a cocktail vaccine of Wilms' tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma. ( 30430205 )
2019
7
What should we tackle next in acute myeloid leukemia? Wilms tumor gene 1 vaccine therapy would be a promising and versatile strategy for acute myeloid leukemia. ( 30882253 )
2019
8
Wilms Tumor-1 (WT1) rs16754 Polymorphism and Clinical Outcome in Acute Myeloid Leukemia ( 30468432 )
2019
9
Phase I/II clinical trial of a Wilms' tumor 1-targeted dendritic cell vaccination-based immunotherapy in patients with advanced cancer. ( 30306202 )
2019
10
Wilms Tumor-1 (WT1) rs16754 Polymorphism ( 30520285 )
2019
11
Inhibition of Heme Oxygenase-1 Activity Enhances Wilms Tumor-1-Specific T-Cell Responses in Cancer Immunotherapy. ( 30678050 )
2019
12
Wilms tumor 1 expression: addressing the 'elephant' in MDS. ( 30714447 )
2019
13
Physiological functions of Wilms' tumor 1-associating protein and its role in tumourigenesis. ( 30756410 )
2019
14
The cell tube block technique and an immunohistochemistry panel including Wilms tumor 1 to assist in diagnosing cavitary effusions in dogs and cats. ( 30865320 )
2019
15
Dietary Turmeric Bisdemethoxycurcumin Suppresses Wilms' Tumor 1 and CD34 Protein Expressions in KG-1a Leukemic Stem Cells. ( 30955364 )
2019
16
The coexistence of a Wilms' tumor and renal cell carcinoma in children: a case report and review of the literature. ( 30774381 )
2019
17
Educational Case: Wilms Tumor (Nephroblastoma). ( 30733996 )
2019
18
Correlations between Histological and Array Comparative Genomic Hybridization Characterizations of Wilms Tumor. ( 30671724 )
2019
19
Synchronous Bilateral Wilms Tumor: Five-Year Single-Center Experience with Assessment of Quality of Life. ( 30686888 )
2019
20
TRIM28 haploinsufficiency predisposes to Wilms tumor. ( 30694527 )
2019
21
Determining the optimal cutoff point for lymph node density and its impact on overall survival in children with Wilms' tumor. ( 30697068 )
2019
22
Botryoid Wilms Tumor: A Rare Diagnosis With an Atypical Presentation. ( 30735745 )
2019
23
The Wilms' tumor suppressor gene regulates pancreas homeostasis and repair. ( 30763305 )
2019
24
Agreement between clinicoradiological signs at diagnosis and radiohistological analysis after neoadjuvant chemotherapy of suspected Wilms tumor rupture: Consequences on therapeutic choices. ( 30773805 )
2019
25
MiR-155-5p affects Wilms' tumor cell proliferation and apoptosis via targeting CREB1. ( 30779069 )
2019
26
Blastemal predominant type Wilms tumor in Japan: Japan Children's Cancer Group. ( 30786111 )
2019
27
Intracardiac Extension of Wilms Tumor: A Case of a 2.5-Year-Old Girl Presenting with Upper Venous Congestion Caused by Tumor Growth into the Right Cardiac Ventricle. ( 30792643 )
2019
28
miR-483-5p Targets MKNK1 to Suppress Wilms' Tumor Cell Proliferation and Apoptosis In Vitro and In Vivo. ( 30798328 )
2019
29
The Natural History of Wilms Tumor - A Case Comparison of Two Different Tumors. ( 30807774 )
2019
30
Salidroside inhibits the growth, migration and invasion of Wilms' tumor cells through down-regulation of miR-891b. ( 30822424 )
2019
31
A1CF-Axin2 signal axis regulates apoptosis and migration in Wilms tumor-derived cells through Wnt/β-catenin pathway. ( 30825095 )
2019
32
Curcumin suppresses wilms' tumor metastasis by inhibiting RECK methylation. ( 30841433 )
2019
33
Association of KRAS and NRAS gene polymorphisms with Wilms tumor risk: a four-center case-control study. ( 30860980 )
2019
34
miR-140-5p alleviates the aggressive progression of Wilms' tumor through directly targeting TGFBR1 gene. ( 30863174 )
2019
35
PAI-1 and protein C as early markers of veno-occlusive disease in patients treated for Wilms tumor. ( 30865371 )
2019
36
Clinical Diagnosis Value of Chest X-Ray and Ultrasound in Recurrence in Patients With Favorable-Histology Wilms Tumor. ( 30875279 )
2019
37
FXR1 expression domain in Wilms tumor. ( 30894247 )
2019
38
Rare clinical condition during Wilms' tumor treatment: Testicular metastasis. ( 30916857 )
2019
39
WARNING: G-401 and SK-NEP-1 cell lines are not Wilms tumor cell lines. ( 30924592 )
2019
40
Late Recurrence of Wilms Tumor After 17 Years: A Case Report. ( 30951024 )
2019
41
How do patient characteristics and anatomical features correlate to accuracy of organ dose reconstruction for Wilms' tumor radiation treatment plans when using a surrogate patient's CT scan? ( 30965301 )
2019
42
Immune expression in children with Wilms tumor: a pilot study. ( 30981637 )
2019
43
Antiangiogenic therapy for Wilms tumor in an adult and literature review. ( 30985306 )
2019
44
miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms' tumor. ( 31035970 )
2019
45
Tumor-suppressive activity of Hnf1β in Wilms' tumor. ( 31038395 )
2019
46
Association of NEFL Gene Polymorphisms with Wilms' Tumor Susceptibility in Chinese Children. ( 31057612 )
2019
47
Successful Treatment of Metastatic Adult Wilms Tumor With Anti-BRAF Treatment: A Case Report and a Brief Review of the Literature. ( 31109800 )
2019
48
Effect of Wilms tumor histology on response to neoadjuvant chemotherapy. ( 29887169 )
2019
49
Autophagy related markers (Beclin-1 and ATG4B) are strongly expressed in Wilms' tumor and correlate with favorable histology. ( 29989143 )
2019
50
Cardiac-Sparing Whole Lung Intensity Modulated Radiation Therapy in Children With Wilms Tumor: Final Report on Technique and Abdominal Field Matching to Maximize Normal Tissue Protection. ( 30096378 )
2019

Variations for Wilms Tumor 6

UniProtKB/Swiss-Prot genetic disease variations for Wilms Tumor 6:

76
# Symbol AA change Variation ID SNP ID
1 REST p.Arg160Pro VAR_076333
2 REST p.Asn290Tyr VAR_076334
3 REST p.His322Arg VAR_076335 rs869025312
4 REST p.His412Gln VAR_076336

ClinVar genetic disease variations for Wilms Tumor 6:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 REST NM_005612.4(REST): c.831_832delAT (p.Cys278Trpfs) deletion risk factor rs869025310 GRCh38 Chromosome 4, 56911469: 56911470
2 REST NM_005612.4(REST): c.831_832delAT (p.Cys278Trpfs) deletion risk factor rs869025310 GRCh37 Chromosome 4, 57777635: 57777636
3 REST NM_005612.4(REST): c.773_776delTGAG (p.Val258Alafs) deletion risk factor rs869025311 GRCh38 Chromosome 4, 56911411: 56911414
4 REST NM_005612.4(REST): c.773_776delTGAG (p.Val258Alafs) deletion risk factor rs869025311 GRCh37 Chromosome 4, 57777577: 57777580
5 REST NM_005612.4(REST): c.965A> G (p.His322Arg) single nucleotide variant risk factor rs869025312 GRCh38 Chromosome 4, 56919853: 56919853
6 REST NM_005612.4(REST): c.965A> G (p.His322Arg) single nucleotide variant risk factor rs869025312 GRCh37 Chromosome 4, 57786019: 57786019

Expression for Wilms Tumor 6

Search GEO for disease gene expression data for Wilms Tumor 6.

Pathways for Wilms Tumor 6

GO Terms for Wilms Tumor 6

Sources for Wilms Tumor 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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