WT6
MCID: WLM011
MIFTS: 48

Wilms Tumor 6 (WT6)

Categories: Cancer diseases, Fetal diseases, Genetic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Wilms Tumor 6

MalaCards integrated aliases for Wilms Tumor 6:

Name: Wilms Tumor 6 57 75 29 6
Wilms Tumor 57 38 25 13 55 6 43 40
Wilms Tumor 6, Susceptibility to 57 75
Wilms Tumor, Susceptibility to 57 75
Nephroblastoma 25 73
Wt6 57 75
Kidney, Adenomyosarcoma, Embryonal 25
Kidney, Carcinosarcoma, Embryonal 25
Susceptibility to Wilms Tumor 6 75
Kidney, Embryonal Mixed Tumor 25
Embryonal Adenosarcoma 25
Renal Cancer, Wilms 25
Embryonal Nephroma 25
Kidney Wilms Tumor 25
Renal Adenosarcoma 25
Renal Wilms Tumor 25
Kidney, Embryoma 25
Wilms' Tumor 25
Tumor, Wilms 25
Nephroma 25

Classifications:



External Ids:

OMIM 57 616806
MeSH 44 D009396
SNOMED-CT via HPO 69 25081006 302849000
UMLS 73 C0027708

Summaries for Wilms Tumor 6

MedlinePlus : 43 Wilms tumor is a rare type of kidney cancer. It causes a tumor on one or both kidneys. It usually affects children, but can happen in adults. Having certain genetic conditions or birth defects can increase the risk of getting it. Children that are at risk should be screened for Wilms tumor every three months until they turn eight. Symptoms include a lump in the abdomen, blood in the urine, and a fever for no reason. Tests that examine the kidney and blood are used to find the tumor. Doctors usually diagnose and remove the tumor in surgery. Other treatments include chemotherapy and radiation and biologic therapies. Biologic therapy boosts your body's own ability to fight cancer. NIH: National Cancer Institute

MalaCards based summary : Wilms Tumor 6, also known as wilms tumor, is related to cervical wilms' tumor and wilms tumor 4, and has symptoms including abdominal pain An important gene associated with Wilms Tumor 6 is REST (RE1 Silencing Transcription Factor). The drug Nitric Oxide has been mentioned in the context of this disorder. Affiliated tissues include kidney, myeloid and bone, and related phenotype is nephroblastoma.

UniProtKB/Swiss-Prot : 75 Wilms tumor 6: A pediatric malignancy of kidney, and the most common childhood abdominal malignancy. It is caused by the uncontrolled multiplication of renal stem, stromal, and epithelial cells.

Description from OMIM: 616806

Related Diseases for Wilms Tumor 6

Diseases in the Hereditary Wilms' Tumor family:

Wilms Tumor 1 Wilms Tumor 2
Wilms Tumor 3 Wilms Tumor 4
Wilms Tumor 5 Wilms Tumor 6
Familial Wilms Tumor 2

Diseases related to Wilms Tumor 6 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 361)
# Related Disease Score Top Affiliating Genes
1 cervical wilms' tumor 12.4
2 wilms tumor 4 12.4
3 cellular congenital mesoblastic nephroma 12.3
4 wilms tumor and radial bilateral aplasia 12.3
5 wilms tumor, aniridia, genitourinary anomalies, mental retardation, and obesity syndrome 12.2
6 wilms tumor predisposition 12.2
7 wilms tumor 1 12.2
8 adult mesoblastic nephroma 12.2
9 wilms tumor 3 12.2
10 epithelial predominant wilms' tumor 12.2
11 mixed cell type kidney wilms' tumor 12.2
12 blastema predominant kidney wilms' tumor 12.2
13 stromal predominant kidney wilms' tumor 12.2
14 metachronous kidney wilms' tumor 12.1
15 familial wilms tumor 2 12.1
16 global developmental delay-lung cysts-overgrowth-wilms tumor syndrome 12.1
17 classic congenital mesoblastic nephroma 12.1
18 frasier syndrome 11.6
19 mulibrey nanism 11.5
20 malignant cystic nephroma 11.5
21 hemihyperplasia, isolated 11.4
22 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 11.4
23 aniridia 1 11.3
24 metanephric adenoma 11.3
25 mosaic variegated aneuploidy syndrome 1 11.2
26 mosaic variegated aneuploidy syndrome 3 11.2
27 mixed epithelial stromal tumour 11.2
28 hyperparathyroidism 2 with jaw tumors 11.1
29 li-fraumeni syndrome 11.1
30 li-fraumeni syndrome 2 11.1
31 rhabdoid tumor predisposition syndrome 1 11.1
32 mosaic variegated aneuploidy syndrome 2 11.1
33 thauvin-robinet-faivre syndrome 11.1
34 simpson-golabi-behmel syndrome 11.1
35 perlman syndrome 11.0
36 wilms tumor 5 11.0
37 myofibromatosis, infantile, 1 11.0
38 infantile myofibromatosis 11.0
39 graham boyle troxell syndrome 11.0
40 aniridia and absent patella 11.0
41 wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 11.0
42 denys-drash syndrome 11.0
43 aniridia 2 11.0
44 ovarian wilms' cancer 11.0
45 embryoma 11.0
46 hereditary wilms' tumor 11.0
47 hemi 3 syndrome 11.0
48 leukemia 10.6
49 myeloid leukemia 10.5
50 leukemia, acute myeloid 10.5

Graphical network of the top 20 diseases related to Wilms Tumor 6:



Diseases related to Wilms Tumor 6

Symptoms & Phenotypes for Wilms Tumor 6

Clinical features from OMIM:

616806

Human phenotypes related to Wilms Tumor 6:

32
# Description HPO Frequency HPO Source Accession
1 nephroblastoma 32 HP:0002667

UMLS symptoms related to Wilms Tumor 6:


abdominal pain

Drugs & Therapeutics for Wilms Tumor 6

Drugs for Wilms Tumor 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitric Oxide Approved 10102-43-9 145068

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acute Effect of Continuous Positive Airway Pressure in Heart Failure Completed NCT01088854 Phase 2
2 Study in Children With the Diagnosis of Congenital Diaphragmatic Hernia (CDH) and Oesophageal Atresia (EA) Completed NCT02466451

Search NIH Clinical Center for Wilms Tumor 6

Genetic Tests for Wilms Tumor 6

Genetic tests related to Wilms Tumor 6:

# Genetic test Affiliating Genes
1 Wilms Tumor 6 29 REST

Anatomical Context for Wilms Tumor 6

MalaCards organs/tissues related to Wilms Tumor 6:

41
Kidney, Myeloid, Bone, T Cells, Bone Marrow, Testes, Lung

Publications for Wilms Tumor 6

Articles related to Wilms Tumor 6:

(show top 50) (show all 1816)
# Title Authors Year
1
Impact of cyclophosphamide and etoposide on outcome of clear cell sarcoma of the kidney treated on the National Wilms Tumor Study-5 (NWTS-5). ( 30255545 )
2019
2
Continuing barriers to care of Wilms tumor in a low-income country. ( 30152039 )
2019
3
Outcome of Wilms tumor patients with bone metastasis enrolled on National Wilms Tumor Studies 1-5: A report from the Children's Oncology Group. ( 30160355 )
2019
4
Paternally inherited WT1 mutation plus uniparental disomy of 11p may be an essential mechanism for development of WT1-mutated familial Wilms tumor. ( 30221469 )
2019
5
Fetal programming and Wilms tumor. ( 30255546 )
2019
6
Maintenance chemotherapy to reduce the risk of a metachronous Wilms tumor in children with bilateral nephroblastomatosis. ( 30334607 )
2019
7
Loss of Wilms tumor 1 protein is a marker for apoptosis in response to replicative stress in leukemic cells. ( 29589053 )
2018
8
Wilms' tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability. ( 29482572 )
2018
9
Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia. ( 29445571 )
2018
10
Wilms' Tumor 1 Overexpression in Granulosa Cells Is Associated with Polycystic Ovaries in Polycystic Ovary Syndrome Patients. ( 29414825 )
2018
11
Quantification of Wilms' tumor 1 mRNA by digital polymerase chain reaction. ( 28994041 )
2018
12
Sensitive detection of rare antigen-specific T cells directed against Wilms' tumor 1 by FluoroSpot assay. ( 28573960 )
2018
13
Polymorphisms in the Wilms Tumor Gene Are Associated With Interindividual Variations in Rubella Virus-Specific Cellular Immunity After Measles-Mumps-Rubella II Vaccination. ( 29253144 )
2018
14
Outcomes of measurable residual disease in pediatric acute myeloid leukemia pre- and post-hematopoietic stem cell transplant: validation of difference from normal flow cytometry with chimerism studies and Wilms tumor 1 gene expression. ( 29933069 )
2018
15
Simultaneous Presentation of Wilms' Tumor and Contralateral Ganglioneuroma in a Child: Case Report and Literature Review. ( 29334535 )
2018
16
Wilms' Tumor 1 Gene Expression Using a Standardized European LeukemiaNet-Certified Assay Compared to Other Methods for Detection of Minimal Residual Disease in Myelodysplastic Syndrome and Acute Myelogenous Leukemia after Allogeneic Blood Stem Cell Transplantation. ( 29753838 )
2018
17
Description of mutation spectrum and polymorphism of Wilms' tumor 1 (WT1) gene in hypospadias patients in the Indonesian population. ( 29958641 )
2018
18
Diagnosis of Beckwith-Wiedemann syndrome in children presenting with Wilms tumor. ( 29932284 )
2018
19
Urine cell-free DNA is a biomarker for nephroblastomatosis or Wilms tumor in PIK3CA-related overgrowth spectrum (PROS). ( 29300373 )
2018
20
Wilms Tumor Associated With the 9q22.3 Microdeletion Syndrome: 2 New Case Reports and a Review of The Literature. ( 30371535 )
2018
21
Synchronous pancreatic tumors in a patient with history of Wilms tumor: A case of pancreatic adenocarcinoma and lipid-rich neuroendocrine tumor diagnosed by cytopathology. ( 30194916 )
2018
22
Benign Multicystic Peritoneal Mesothelioma in a Male Patient with Previous Wilms' Tumor: A Case Report and Review of the Literature. ( 30155337 )
2018
23
Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment of Wilms tumor. ( 30021048 )
2018
24
Wilms' tumor 1-associating protein plays an aggressive role in diffuse large B-cell lymphoma and forms a complex with BCL6 via Hsp90. ( 30143009 )
2018
25
Co-inhibition of TIGIT, PD1, and Tim3 reverses dysfunction of Wilms tumor protein-1 (WT1)-specific CD8+ T lymphocytes after dendritic cell vaccination in gastric cancer. ( 30210924 )
2018
26
A phase I clinical study of a cocktail vaccine of Wilms' tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma. ( 30430205 )
2018
27
Possible Correlation between Hypomelanosis of Ito and Wilms' Tumor. ( 30123603 )
2018
28
The clinical significance of the alternative Wilms tumor gene overexpression-hypermethylation signature in acute myeloid leukemia. ( 30506133 )
2018
29
Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease. ( 30135315 )
2018
30
Associations between the peripheral blood Wilms tumor gene 1 level and both bone marrow blast cells and the prognosis in patients with myelodysplastic syndrome. ( 30188227 )
2018
31
The Wilms' tumor gene-1 is a prognostic factor in myelodysplastic syndrome: a meta analysis. ( 29662637 )
2018
32
Re: Comparing Oncologic Outcomes after Minimally Invasive and Open Surgery for Pediatric Neuroblastoma and Wilms Tumor. ( 30360320 )
2018
33
Bioanalysis of a panel of neurotransmitters and their metabolites in plasma samples obtained from pediatric patients with neuroblastoma and Wilms' tumor. ( 29351866 )
2018
34
Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor. ( 28792662 )
2018
35
Prognostic significance of Wilms' tumor 1 expression in patients with pancreatic ductal adenocarcinoma. ( 30008944 )
2018
36
Wilms tumor, pleuropulmonary blastoma, and DICER1: case report and literature review. ( 30097050 )
2018
37
Adult Presentation of Noncirrhotic Portal Hypertension and Ascites following Treatment for Wilms' Tumor in Childhood. ( 29515345 )
2018
38
Overexpression of Wilms' tumor 1 in skin lesions of psoriasis is associated with abnormal proliferation and apoptosis of keratinocytes. ( 30132523 )
2018
39
Prognostic significance of The Wilms' Tumor-1 (WT1) rs16754 polymorphism in acute myeloid leukemia. ( 29407184 )
2018
40
Wilms' tumor 1 (WT1) as a prognosis factor in gynecological cancers: A meta-analysis. ( 29995811 )
2018
41
Wilms Tumor 1 Expression at Diagnosis Correlates With Genetic Abnormalities and Polymorphism But Is Not Independently Prognostic in Acute Myelogenous Leukemia: A Hokkaido Leukemia Net Study. ( 30082223 )
2018
42
Phase I/II clinical trial of a Wilms' tumor 1-targeted dendritic cell vaccination-based immunotherapy in patients with advanced cancer. ( 30306202 )
2018
43
Wilms Tumor After Orthotopic Liver Transplant in a Patient With Alagille Syndrome. ( 29879405 )
2018
44
Cancer Management in Kabuki Syndrome: The First Case of Wilms Tumor and a Literature Review. ( 29489735 )
2018
45
Outcome and Prognostic Factors in Stage III Favorable-Histology Wilms Tumor: A Report From the Children's Oncology Group Study AREN0532. ( 29211618 )
2018
46
Three-dimensional printed model of bilateral Wilms tumor: A useful tool for planning nephron sparing surgery. ( 29230948 )
2018
47
Identification of a novel CTR9 germline mutation in a family with Wilms tumor. ( 29292210 )
2018
48
Cecal Volvulus following a Right Nephrectomy for Wilms' Tumor: Should We Need to Close the Lateral Peritoneum? ( 29318103 )
2018
49
Unilateral Wilms tumor: The relevance of pre- and postnephrectomy evaluation of renal function. ( 29350480 )
2018
50
Retrospective analysis to determine outcomes of patients with bilateral Wilms tumor undergoing nephron sparing surgery: 15-year tertiary single-institution experience. ( 29368077 )
2018

Variations for Wilms Tumor 6

UniProtKB/Swiss-Prot genetic disease variations for Wilms Tumor 6:

75
# Symbol AA change Variation ID SNP ID
1 REST p.Arg160Pro VAR_076333
2 REST p.Asn290Tyr VAR_076334
3 REST p.His322Arg VAR_076335 rs869025312
4 REST p.His412Gln VAR_076336

ClinVar genetic disease variations for Wilms Tumor 6:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 REST NM_005612.4(REST): c.831_832delAT (p.Cys278Trpfs) deletion risk factor rs869025310 GRCh38 Chromosome 4, 56911469: 56911470
2 REST NM_005612.4(REST): c.831_832delAT (p.Cys278Trpfs) deletion risk factor rs869025310 GRCh37 Chromosome 4, 57777635: 57777636
3 REST NM_005612.4(REST): c.773_776delTGAG (p.Val258Alafs) deletion risk factor rs869025311 GRCh38 Chromosome 4, 56911411: 56911414
4 REST NM_005612.4(REST): c.773_776delTGAG (p.Val258Alafs) deletion risk factor rs869025311 GRCh37 Chromosome 4, 57777577: 57777580
5 REST NM_005612.4(REST): c.965A> G (p.His322Arg) single nucleotide variant risk factor rs869025312 GRCh38 Chromosome 4, 56919853: 56919853
6 REST NM_005612.4(REST): c.965A> G (p.His322Arg) single nucleotide variant risk factor rs869025312 GRCh37 Chromosome 4, 57786019: 57786019

Expression for Wilms Tumor 6

Search GEO for disease gene expression data for Wilms Tumor 6.

Pathways for Wilms Tumor 6

GO Terms for Wilms Tumor 6

Sources for Wilms Tumor 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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