WAGRO
MCID: WLM019
MIFTS: 17

Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome (WAGRO)

Categories: Mental diseases, Metabolic diseases, Neuronal diseases

Aliases & Classifications for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

MalaCards integrated aliases for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome:

Name: Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome 57 29 6 39 70
Wagro Syndrome 57 13
Chromosome 11p13-P12 Deletion Syndrome 57
Wagr Syndrome with Obesity 57
Wagro 57

Classifications:



External Ids:

OMIM® 57 612469
MedGen 41 C2675904
UMLS 70 C2675904

Summaries for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

OMIM® : 57 For a detailed discussion of the WAGR syndrome, see 194072. In a subgroup of individuals with the WAGR syndrome, obesity develops. The phenotype in this subset is associated with haploinsufficiency for the BDNF gene. (612469) (Updated 20-May-2021)

MalaCards based summary : Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome, also known as wagro syndrome, is related to wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome and aniridia 1. An important gene associated with Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome is WAGRO (WAGRO Syndrome). Affiliated tissues include brain.

Related Diseases for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

Diseases related to Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 wilms tumor, aniridia, genitourinary anomalies, and mental retardation syndrome 11.0
2 aniridia 1 10.1
3 succinic semialdehyde dehydrogenase deficiency 10.1
4 gamma-amino butyric acid metabolism disorder 10.1
5 hydrocephalus 10.1
6 lens subluxation 9.9
7 syndromic obesity 9.9

Graphical network of the top 20 diseases related to Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome:



Diseases related to Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome

Symptoms & Phenotypes for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

Clinical features from OMIM®:

612469 (Updated 20-May-2021)

Drugs & Therapeutics for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

Search Clinical Trials , NIH Clinical Center for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome

Genetic Tests for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

Genetic tests related to Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome:

# Genetic test Affiliating Genes
1 Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome 29

Anatomical Context for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

MalaCards organs/tissues related to Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome:

40
Brain

Publications for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

Articles related to Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome:

# Title Authors PMID Year
1
Aniridia. 6
22692063 2012
2
Brain-derived neurotrophic factor and obesity in the WAGR syndrome. 57
18753648 2008
3
Combination of WAGR and Potocki-Shaffer contiguous deletion syndromes in a patient with an 11p11.2-p14 deletion. 57
15702131 2005
4
Third case of WAGR syndrome with severe obesity and constitutional deletion of chromosome (11)(p12p14). 57
11807873 2002
5
Obesity and WAGR syndrome. 57
10649802 2000
6
Obesity: a new feature of WAGR (del 11p) syndrome. 57
7526938 1994
7
WAGRO syndrome: a rare genetic condition associated with aniridia and additional ophthalmologic abnormalities. 61
31116317 2019
8
The modifier effect of the BDNF gene in the phenotype of the WAGRO syndrome. 61
23266638 2013
9
Clinical, cytogenetic and molecular characterization of a patient with combined succinic semialdehyde dehydrogenase deficiency and incomplete WAGR syndrome with obesity. 61
16545979 2006

Variations for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

ClinVar genetic disease variations for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 overlap with 41 genes GRCh37/hg19 11p15.1-13(chr11:21586131-33168232)x1 copy number loss Pathogenic 376759 GRCh37: 11:21586131-33168232
GRCh38:

Expression for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

Search GEO for disease gene expression data for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, and Obesity Syndrome.

Pathways for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

GO Terms for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

Sources for Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental...

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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