Aliases & Classifications for Withdrawal Disorder

MalaCards integrated aliases for Withdrawal Disorder:

Name: Withdrawal Disorder 12 15
Withdrawal Syndrome 55 15
Substance Withdrawal Syndrome 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060001
UMLS 73 C0038587

Summaries for Withdrawal Disorder

Disease Ontology : 12 A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol.

MalaCards based summary : Withdrawal Disorder, also known as withdrawal syndrome, is related to opiate dependence and heroin dependence, and has symptoms including seizures, opiate withdrawal symptoms and drug withdrawal symptoms. An important gene associated with Withdrawal Disorder is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Affiliated tissues include prostate, brain and heart, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Withdrawal Disorder

Diseases related to Withdrawal Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 opiate dependence 32.0 OPRM1 PDYN POMC
2 heroin dependence 31.7 OPRM1 PDYN
3 anxiety 29.9 CNR1 CRH TSPO
4 alcohol dependence 29.6 CNR1 OPRM1 PDYN POMC TSPO
5 panic disorder 29.3 CRH POMC TSPO
6 eating disorder 29.3 CNR1 CRH POMC
7 drug dependence 28.9 CNR1 CRH OPRM1 PDYN POMC
8 barbiturate dependence 11.3
9 neonatal abstinence syndrome 10.9
10 nodular prostate 10.2 AR KLK3
11 cyclic vomiting syndrome 10.2 CNR1 OPRM1
12 androgenic alopecia 10.2 AR KLK3
13 prostate cancer 10.2
14 prostatic hyperplasia, benign 10.2 AR KLK3
15 opioid abuse 10.2 OPRM1 PDYN
16 prostatic hypertrophy 10.2 AR KLK3
17 morphine dependence 10.2 FOS OPRM1
18 prostate adenoid cystic carcinoma 10.2 KLK3 POMC
19 tuberculous epididymitis 10.2 KLK3 POMC
20 postmenopausal atrophic vaginitis 10.1 AR POMC
21 motion sickness 10.1 FOS HTR7
22 male reproductive organ benign neoplasm 10.1 KLK3 POMC
23 cystitis cystica 10.1 AR KLK3
24 retrograde amnesia 10.1 PDYN POMC
25 atypical depressive disorder 10.1 CRH HTR7
26 sex differentiation disease 10.1 AR POMC
27 separation anxiety disorder 10.1 HTR7 OPRM1 TSPO
28 cutaneous solitary mastocytoma 10.1 PDYN POMC
29 gynecomastia 10.1 AR KLK3 POMC
30 drug-induced mental disorder 10.1 CNR1 FOS HTR7
31 drug psychosis 10.1 CNR1 FOS HTR7
32 hypothalamic disease 10.1 CRH POMC
33 gangliocytoma 10.1 CRH POMC
34 fibromyalgia 10.1 CRH TSPO
35 pituitary carcinoma 10.0 CRH POMC
36 acth deficiency, isolated 10.0 CRH POMC
37 nelson syndrome 10.0 CRH POMC
38 sheehan syndrome 10.0 CRH POMC
39 hypoadrenalism 10.0 CRH POMC
40 migraine with or without aura 1 10.0 CNR1 FOS HTR7
41 acth-secreting pituitary adenoma 10.0 CRH POMC
42 substance dependence 10.0 CNR1 OPRM1 POMC
43 fasting hypoglycemia 10.0 CRH POMC
44 adrenal cortical hypofunction 10.0 CRH POMC
45 cocaine dependence 10.0 OPRM1 PDYN POMC
46 ectopic cushing syndrome 10.0 CRH POMC
47 persistent fetal circulation syndrome 10.0 CRH POMC
48 premenstrual tension 10.0 CRH POMC
49 gonadal disease 10.0 AR CRH POMC
50 hypothyroidism, congenital, nongoitrous, 4 10.0 CRH POMC

Graphical network of the top 20 diseases related to Withdrawal Disorder:



Diseases related to Withdrawal Disorder

Symptoms & Phenotypes for Withdrawal Disorder

UMLS symptoms related to Withdrawal Disorder:


seizures, opiate withdrawal symptoms, drug withdrawal symptoms, withdrawal symptoms

MGI Mouse Phenotypes related to Withdrawal Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.16 AR CNR1 CRH FOS HTR7 JAG1
2 homeostasis/metabolism MP:0005376 10.06 AR CNR1 CRH FOS HTR7 JAG1
3 cellular MP:0005384 10.03 AR CNR1 CRH FOS JAG1 OPRM1
4 growth/size/body region MP:0005378 10.02 AR CNR1 CRH FOS JAG1 OPRM1
5 adipose tissue MP:0005375 9.95 AR CNR1 CRH OPRM1 PDYN POMC
6 endocrine/exocrine gland MP:0005379 9.95 AR CRH FOS JAG1 OPRM1 POMC
7 integument MP:0010771 9.91 AR CNR1 CRH FOS HTR7 JAG1
8 nervous system MP:0003631 9.81 AR CNR1 CRH FOS HTR7 JAG1
9 no phenotypic analysis MP:0003012 9.43 CNR1 CRH JAG1 OPRM1 PDYN POMC
10 normal MP:0002873 9.17 AR CNR1 CRH FOS JAG1 OPRM1

Drugs & Therapeutics for Withdrawal Disorder

Genetic Tests for Withdrawal Disorder

Anatomical Context for Withdrawal Disorder

MalaCards organs/tissues related to Withdrawal Disorder:

41
Prostate, Brain, Heart, Liver, Myeloid, Cortex, Thyroid

Publications for Withdrawal Disorder

Articles related to Withdrawal Disorder:

(show top 50) (show all 1007)
# Title Authors Year
1
Recognition, Assessment, and Pharmacotherapeutic Treatment of Alcohol Withdrawal Syndrome in the Intensive Care Unit. ( 30507660 )
2019
2
Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis. ( 30498775 )
2018
3
Prenatal Opioid Exposure, Neonatal Abstinence Syndrome/Neonatal Opioid Withdrawal Syndrome, and Later Child Development Research: Shortcomings and Solutions. ( 30334926 )
2018
4
Lofexidine versus diazepam for the treatment of opioid withdrawal syndrome: A double-blind randomized clinical trial in Singapore. ( 29910009 )
2018
5
Alcohol withdrawal syndrome: diagnostic and therapeutic methods. ( 29912213 )
2018
6
The Safety and Utility of Phenobarbital Use for the Treatment of Severe Alcohol Withdrawal Syndrome in the Medical Intensive Care Unit. ( 29925291 )
2018
7
Baclofen-Induced Neuro-Respiratory Toxicity in the Rat: Contribution of Tolerance and Characterization of Withdrawal Syndrome. ( 29945230 )
2018
8
Psychopharmacological effects and safety of styryl-2-pyrones and dihydrostyryl-2-pyrones-rich fraction from Polygala sabulosa: absence of withdrawal syndrome and tolerance to anxiolytic-like and anticonvulsant effects. ( 29956326 )
2018
9
Correlation Between mMINDS and CIWA-Ar Scoring Tools in Patients With Alcohol Withdrawal Syndrome. ( 29961663 )
2018
10
A subtype-specific neuropeptide FF receptor antagonist attenuates morphine and nicotine withdrawal syndrome in the rat. ( 29981879 )
2018
11
Life-threatening DBS withdrawal syndrome in Parkinson's disease can be treated with early reimplantation. ( 30007510 )
2018
12
Systematic review of acupuncture for the treatment of alcohol withdrawal syndrome. ( 30030272 )
2018
13
Will This Hospitalized Patient Develop Severe Alcohol Withdrawal Syndrome?: The Rational Clinical Examination Systematic Review. ( 30167704 )
2018
14
Diagnosis and treatment of acute alcohol intoxication and alcohol withdrawal syndrome: position paper of the Italian Society on Alcohol. ( 30187438 )
2018
15
Parent's experiences of their child's withdrawal syndrome: a driver for reciprocal nurse-parent partnership in withdrawal assessment. ( 30224222 )
2018
16
Symptom-triggered therapy for assessment and management of alcohol withdrawal syndrome in the emergency department short-stay clinical decision unit. ( 30282630 )
2018
17
Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats. ( 30297685 )
2018
18
DSM-5 cannabis withdrawal syndrome: Demographic and clinical correlates in U.S. adults. ( 30361043 )
2018
19
Treatment of Alcohol Withdrawal Syndrome: Phenobarbital vs CIWA-Ar Protocol. ( 30385536 )
2018
20
Lofexidine for Treating Opioid Withdrawal Syndrome in Palliative Care Patients. ( 30410274 )
2018
21
Comparison of phenobarbital-adjunct versus benzodiazepine-only approach for alcohol withdrawal syndrome in the emergency department. ( 30414743 )
2018
22
Impact of In-utero Exposure to Selective Serotonin Reuptake Inhibitors and Opioids on Neonatal Opioid Withdrawal Syndrome. ( 30489344 )
2018
23
Association between prenatal opioid exposure, neonatal opioid withdrawal syndrome, and neurodevelopmental and behavioral outcomes at 5-8 months of age. ( 30554024 )
2018
24
Antiandrogen withdrawal syndrome (AAWS) in the treatment of patients with prostate cancer. ( 28971898 )
2018
25
Ivacaftor withdrawal syndrome in cystic fibrosis patients with the G551D mutation. ( 29079142 )
2018
26
A Practical Approach to Neonatal Opiate Withdrawal Syndrome. ( 29100261 )
2018
27
Ketogenic Diet Suppresses Alcohol Withdrawal Syndrome in Rats. ( 29160944 )
2018
28
Sodium Oxybate Therapy for Alcohol Withdrawal Syndrome and Keeping of Alcohol Abstinence. ( 29219048 )
2018
29
Incidence rates of admissions associated with alcohol withdrawal syndrome in Spain: Analysis of minimum basic data set 1999-2010. ( 29274671 )
2018
30
Is medical treatment of Alcohol Withdrawal Syndrome a Stag Hunt? Challenges and opportunities in managing risk and uncertainty in addiction cessation. ( 29317849 )
2018
31
Abiraterone acetate withdrawal syndrome: Speculations on the underlying mechanisms. ( 29434990 )
2018
32
Blood biomarkers of Hikikomori, a severe social withdrawal syndrome. ( 29440704 )
2018
33
Disulfiram attenuates morphine or methadone withdrawal syndrome in mice. ( 29462108 )
2018
34
Management of Tizanidine Withdrawal Syndrome: A Case Report. ( 29467587 )
2018
35
Current Practice Patterns in the Management Of Alcohol Withdrawal Syndrome. ( 29491698 )
2018
36
Routine screening and related interventions significantly improve the effectiveness of emergency department detection and management of alcohol withdrawal syndrome. ( 29529713 )
2018
37
Low dose intramuscular methadone for acute mild to moderate opioid withdrawal syndrome. ( 29544903 )
2018
38
Long-term abiraterone withdrawal syndrome. ( 29722038 )
2018
39
Implementation of an ICU-Specific Alcohol Withdrawal Syndrome Management Protocol Reduces the Need for Mechanical Ventilation. ( 29800507 )
2018
40
Olfactory deficit as a result of clozapine withdrawal syndrome in an animal model of schizophrenia: preliminary results. ( 29898114 )
2018
41
Addison's Disease and Possible Cannabis Withdrawal Syndrome Presenting as an Eating Disorder in a Thirty-Year-Old Female. ( 28348901 )
2017
42
Obesity and the Social Withdrawal Syndrome. ( 28407567 )
2017
43
Transdermal Scopolamine Withdrawal Syndrome Case Report in the Pediatric Cerebral Palsy Population. ( 28081025 )
2017
44
The Impact of Saffron on Symptoms of Withdrawal Syndrome in Patients Undergoing Maintenance Treatment for Opioid Addiction in Sabzevar Parish in 2017. ( 29359178 )
2017
45
Incidence and Characterization of Antiandrogen Withdrawal Syndrome After Discontinuation of Treatment With Enzalutamide in Castration-resistant Prostate Cancer. ( 28958675 )
2017
46
Dopamine agonist withdrawal syndrome (DAWS) in a tertiary Parkinson disease treatment center. ( 28716269 )
2017
47
Patient, Process, and System Predictors of Iatrogenic Withdrawal Syndrome in Critically Ill Children. ( 27513532 )
2017
48
Alcohol withdrawal syndrome: mechanisms, manifestations, and management. ( 27586815 )
2017
49
A Symptom-Triggered Benzodiazepine Protocol Utilizing SAS and CIWA-Ar Scoring for the Treatment of Alcohol Withdrawal Syndrome in the Critically Ill. ( 27733668 )
2017
50
An Atypical Withdrawal Syndrome in Neonates Prenatally Exposed to Gabapentin and Opioids. ( 27889067 )
2017

Variations for Withdrawal Disorder

Expression for Withdrawal Disorder

Search GEO for disease gene expression data for Withdrawal Disorder.

Pathways for Withdrawal Disorder

GO Terms for Withdrawal Disorder

Biological processes related to Withdrawal Disorder according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.71 CNR1 FOS TSPO
2 response to lipopolysaccharide GO:0032496 9.7 CNR1 FOS OPRM1
3 G protein-coupled receptor signaling pathway GO:0007186 9.63 CNR1 CRH HTR7 OPRM1 PDYN POMC
4 response to ethanol GO:0045471 9.58 CNR1 CRH OPRM1
5 response to progesterone GO:0032570 9.56 FOS TSPO
6 response to morphine GO:0043278 9.55 CNR1 OPRM1
7 response to immobilization stress GO:0035902 9.51 CRH FOS
8 adrenal gland development GO:0030325 9.49 CRH TSPO
9 response to corticosterone GO:0051412 9.48 CRH FOS
10 response to pain GO:0048265 9.46 CRH TSPO
11 regulation of NMDA receptor activity GO:2000310 9.43 CRH OPRM1
12 neuropeptide signaling pathway GO:0007218 9.43 OPRM1 PDYN POMC
13 regulation of synaptic transmission, GABAergic GO:0032228 9.37 CNR1 NISCH
14 regulation of systemic arterial blood pressure GO:0003073 9.32 AR KLK3
15 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.13 CNR1 HTR7 OPRM1
16 response to cocaine GO:0042220 8.8 CNR1 CRH OPRM1
17 signal transduction GO:0007165 10.04 AR CNR1 CRH HTR7 OPRM1 POMC

Molecular functions related to Withdrawal Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 androgen binding GO:0005497 8.62 AR TSPO

Sources for Withdrawal Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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