Aliases & Classifications for Withdrawal Disorder

MalaCards integrated aliases for Withdrawal Disorder:

Name: Withdrawal Disorder 12 15
Substance Withdrawal Syndrome 73
Withdrawal Syndrome 55

Classifications:



External Ids:

Disease Ontology 12 DOID:0060001
UMLS 73 C0038587

Summaries for Withdrawal Disorder

Disease Ontology : 12 A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol.

MalaCards based summary : Withdrawal Disorder, also known as substance withdrawal syndrome, is related to barbiturate dependence and prostatic adenoma, and has symptoms including seizures, drug withdrawal symptoms and withdrawal symptoms. An important gene associated with Withdrawal Disorder is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Affiliated tissues include prostate, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Withdrawal Disorder

Diseases related to Withdrawal Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 barbiturate dependence 11.1
2 prostatic adenoma 10.8 AR KLK3
3 nodular prostate 10.8 AR KLK3
4 neonatal abstinence syndrome 10.8
5 prostatic acinar adenocarcinoma 10.8 AR KLK3
6 cyclic vomiting syndrome 10.7 CNR1 OPRM1
7 chronic pain 10.7 CNR1 OPRM1
8 prostatic hyperplasia, benign 10.7 AR KLK3
9 androgenic alopecia 10.6 AR KLK3
10 opioid abuse 10.6 OPRM1 PDYN
11 morphine dependence 10.6 FOS OPRM1
12 heroin dependence 10.5 OPRM1 PDYN
13 prostatic hypertrophy 10.5 AR KLK3
14 motion sickness 10.4 FOS HTR7
15 cystitis cystica 10.3 AR KLK3
16 separation anxiety disorder 10.3 HTR7 OPRM1 TSPO
17 prostate adenoid cystic carcinoma 10.2 KLK3 POMC
18 tuberculous epididymitis 10.2 KLK3 POMC
19 atypical depressive disorder 10.2 CRH HTR7
20 drug-induced mental disorder 10.2 CNR1 FOS HTR7
21 drug psychosis 10.2 CNR1 FOS HTR7
22 fibromyalgia 10.1 CRH TSPO
23 suprasellar meningioma 10.1 KLK3 POMC
24 migraine with or without aura 1 10.1 CNR1 FOS HTR7
25 retrograde amnesia 10.0 PDYN POMC
26 anxiety 9.9 CNR1 CRH TSPO
27 cutaneous solitary mastocytoma 9.9 PDYN POMC
28 sex differentiation disease 9.9 AR POMC
29 gynecomastia 9.9 AR KLK3 POMC
30 epilepsy, idiopathic generalized 9.8 OPRM1 POMC TSPO
31 substance dependence 9.8 CNR1 OPRM1 POMC
32 opiate dependence 9.7 OPRM1 PDYN POMC
33 cocaine dependence 9.7 OPRM1 PDYN POMC
34 hypothalamic disease 9.7 CRH POMC
35 pituitary carcinoma 9.7 CRH POMC
36 acth deficiency, isolated 9.7 CRH POMC
37 nelson syndrome 9.7 CRH POMC
38 sheehan syndrome 9.7 CRH POMC
39 hypoadrenalism 9.7 CRH POMC
40 acth-secreting pituitary adenoma 9.6 CRH POMC
41 fasting hypoglycemia 9.6 CRH POMC
42 adrenal cortical hypofunction 9.6 CRH POMC
43 adrenal cortex disease 9.5 CRH POMC
44 adrenal gland disease 9.5 CRH POMC
45 urinary system disease 9.4 CRH KLK3 POMC
46 ectopic cushing syndrome 9.4 CRH POMC
47 gonadal disease 9.4 AR CRH POMC
48 amnestic disorder 9.4 CNR1 FOS HTR7 PDYN TSPO
49 persistent fetal circulation syndrome 9.4 CRH POMC
50 panic disorder 9.4 CRH POMC TSPO

Graphical network of the top 20 diseases related to Withdrawal Disorder:



Diseases related to Withdrawal Disorder

Symptoms & Phenotypes for Withdrawal Disorder

UMLS symptoms related to Withdrawal Disorder:


seizures, drug withdrawal symptoms, withdrawal symptoms, opiate withdrawal symptoms

MGI Mouse Phenotypes related to Withdrawal Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.16 CNR1 JAG1 CRH OPRM1 FOS AR
2 homeostasis/metabolism MP:0005376 10.06 HTR7 CNR1 JAG1 CRH NPL OPRM1
3 cellular MP:0005384 10.03 CNR1 JAG1 CRH FOS AR POMC
4 growth/size/body region MP:0005378 10.02 CNR1 JAG1 CRH FOS AR PDYN
5 adipose tissue MP:0005375 9.95 CNR1 CRH OPRM1 AR POMC PDYN
6 endocrine/exocrine gland MP:0005379 9.95 JAG1 CRH FOS AR POMC TSPO
7 integument MP:0010771 9.91 JAG1 CRH OPRM1 FOS AR HTR7
8 nervous system MP:0003631 9.81 HTR7 CNR1 JAG1 CRH OPRM1 FOS
9 no phenotypic analysis MP:0003012 9.43 CNR1 JAG1 CRH POMC OPRM1 PDYN
10 normal MP:0002873 9.17 CNR1 JAG1 CRH OPRM1 FOS AR

Drugs & Therapeutics for Withdrawal Disorder

Genetic Tests for Withdrawal Disorder

Anatomical Context for Withdrawal Disorder

MalaCards organs/tissues related to Withdrawal Disorder:

41
Prostate

Publications for Withdrawal Disorder

Articles related to Withdrawal Disorder:

(show top 50) (show all 61)
# Title Authors Year
1
Addison's Disease and Possible Cannabis Withdrawal Syndrome Presenting as an Eating Disorder in a Thirty-Year-Old Female. ( 28348901 )
2017
2
Obesity and the Social Withdrawal Syndrome. ( 28407567 )
2017
3
Transdermal Scopolamine Withdrawal Syndrome Case Report in the Pediatric Cerebral Palsy Population. ( 28081025 )
2017
4
The Impact of Saffron on Symptoms of Withdrawal Syndrome in Patients Undergoing Maintenance Treatment for Opioid Addiction in Sabzevar Parish in 2017. ( 29359178 )
2017
5
Incidence and Characterization of Antiandrogen Withdrawal Syndrome After Discontinuation of Treatment With Enzalutamide in Castration-resistant Prostate Cancer. ( 28958675 )
2017
6
Carisoprodol withdrawal syndrome resembling neuroleptic malignant syndrome: Diagnostic dilemma. ( 27625493 )
2016
7
Long-term complete response of antiandrogen withdrawal syndrome in a patient with metastatic prostate cancer: A case report. ( 27588183 )
2016
8
Efficacy of acamprosate for the treatment of alcohol dependence long after recovery from withdrawal syndrome: a randomized, double-blind, placebo-controlled study conducted in Japan (Sunrise Study). ( 25742205 )
2015
9
Evaluation of prostate-specific antigen response following cessation of abiraterone acetate: is there evidence for a withdrawal syndrome? ( 24210911 )
2014
10
Dopamine agonist withdrawal syndrome in a patient with restless legs syndrome without impulse control disorder or drug abuse. ( 25362251 )
2014
11
Sodium oxybate: a review of its use in alcohol withdrawal syndrome and in the maintenance of abstinence in alcohol dependence. ( 24307430 )
2014
12
Sodium oxybate in the treatment of alcohol dependence: from the alcohol withdrawal syndrome to the alcohol relapse prevention. ( 24283802 )
2014
13
Opioid withdrawal syndrome after treatment with low-dose extended-release oxycodone and naloxone in a gastric cancer patient with portal vein thrombosis. ( 23680581 )
2013
14
Dopamine agonist withdrawal syndrome in a patient with restless legs syndrome. ( 22749683 )
2013
15
Influence of DRD2 and ANKK1 polymorphisms on the manifestation of withdrawal syndrome symptoms in alcohol addiction. ( 23238469 )
2012
16
[Mechanism of withdrawal syndrome in alcohol dependence]. ( 22256590 )
2011
17
Multiple 100 Hz electroacupuncture treatments produced cumulative effect on the suppression of morphine withdrawal syndrome: Central preprodynorphin mRNA and p-CREB implicated. ( 21167242 )
2011
18
Antiandrogen withdrawal syndrome and alternative antiandrogen therapy associated with the W741C mutant androgen receptor in a novel prostate cancer xenograft. ( 19790238 )
2010
19
Intra-cornu ammonis 1 administration of the human immunodeficiency virus-1 protein trans-activator of transcription exacerbates the ethanol withdrawal syndrome in rodents and activates N-methyl-D-aspartate glutamate receptors to produce persisting spatial learning deficits. ( 19619615 )
2009
20
[Estramustine phosphate withdrawal syndrome in relapsed prostate cancer: two case reports]. ( 18634439 )
2008
21
Carisoprodol withdrawal syndrome misdiagnosed as a psychotic disorder. ( 18633744 )
2008
22
Genetic dissociation of two behaviors associated with nicotine addiction: beta-2 containing nicotinic receptors are involved in nicotine reinforcement but not in withdrawal syndrome. ( 16752141 )
2006
23
Suppression of morphine withdrawal syndrome by interleukin-2 and its gene. ( 15729143 )
2005
24
Withdrawal syndrome in a drug addict caused diagnostic delay of spontaneous bilateral carotid artery dissection. ( 15632548 )
2005
25
Impact of alcohol intoxication and withdrawal syndrome on social phobia and panic disorder in alcoholic inpatients. ( 15361983 )
2004
26
Role of GABA(B) receptor in alcohol dependence: reducing effect of baclofen on alcohol intake and alcohol motivational properties in rats and amelioration of alcohol withdrawal syndrome and alcohol craving in human alcoholics. ( 15545024 )
2004
27
Behavioral effects of potentiated antibodies to morphine and mu-opioid receptors during withdrawal syndrome. ( 12949640 )
2003
28
Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome. ( 12517791 )
2003
29
Does the DRD2-Taq1 A polymorphism influence treatment response to bupropion hydrochloride for reduction of the nicotine withdrawal syndrome? ( 14668077 )
2003
30
Role of central histaminergic system in lorazepam withdrawal syndrome in rats. ( 11526976 )
2001
31
Neonatal paroxetine withdrawal syndrome or actually serotonin syndrome? ( 11561552 )
2001
32
Antiandrogen withdrawal syndrome associated with prostate cancer therapies: incidence and clinical significance. ( 11085345 )
2000
33
GH dependence and GH withdrawal syndrome in GH treatment of short normal children: evidence from growth and cardiac output. ( 9578507 )
1998
34
Prolonged prostate-specific antigen response in flutamide withdrawal syndrome despite disease progression. ( 9634122 )
1998
35
[Antiandrogen withdrawal syndrome]. ( 9750522 )
1998
36
Endocrine withdrawal syndrome and its relevance to the management of hormone refractory prostate cancer. ( 9854191 )
1998
37
Incidence and characteristics of antiandrogen withdrawal syndrome in prostate cancer after treatment with chlormadinone acetate. ( 9743699 )
1998
38
Antiandrogen withdrawal syndrome with nilutamide. ( 9111642 )
1997
39
[An equivalent of anti-androgen withdrawal syndrome: decrease of prostate specific antigen and clinical response to estramustine phosphate withdrawal]. ( 9180872 )
1997
40
The antiandrogen withdrawal syndrome in relapsed prostate cancer. ( 9074903 )
1997
41
The antiandrogen withdrawal syndrome. ( 9144890 )
1997
42
[The antiandrogen withdrawal syndrome: decrease in prostate specific antigen serum levels after withdrawal of antiandrogens]. ( 9471771 )
1997
43
[Antiandrogen withdrawal syndrome in the hormonal treatment of metastatic prostatic cancer in hormonal escape]. ( 8624534 )
1996
44
Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome. ( 8827083 )
1996
45
Antiandrogen withdrawal syndrome in prostate cancer after treatment with steroidal antiandrogen chlormadinone acetate. ( 7536369 )
1995
46
Chlormadinone acetate withdrawal syndrome under combined androgen blockade for advanced prostate cancer. ( 7545251 )
1995
47
Tolerance, drug dependence and withdrawal syndrome in antiepileptic drugs. ( 8655043 )
1995
48
The antiandrogen withdrawal syndrome. Experience in a large cohort of unselected patients with advanced prostate cancer. ( 8620419 )
1995
49
Dramatic prostate specific antigen decrease in response to discontinuation of megestrol acetate in advanced prostate cancer: expansion of the antiandrogen withdrawal syndrome. ( 7538601 )
1995
50
Double-blind study of alprazolam, diazepam, clonidine, and placebo in the alcohol withdrawal syndrome: preliminary findings. ( 7978098 )
1994

Variations for Withdrawal Disorder

Expression for Withdrawal Disorder

Search GEO for disease gene expression data for Withdrawal Disorder.

Pathways for Withdrawal Disorder

GO Terms for Withdrawal Disorder

Biological processes related to Withdrawal Disorder according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.75 CNR1 FOS OPRM1
2 aging GO:0007568 9.73 CNR1 FOS TSPO
3 G-protein coupled receptor signaling pathway GO:0007186 9.73 CNR1 CRH HTR7 OPRM1 PDYN POMC
4 response to ethanol GO:0045471 9.63 CNR1 CRH OPRM1
5 response to morphine GO:0043278 9.57 CNR1 OPRM1
6 response to immobilization stress GO:0035902 9.55 CRH FOS
7 response to pain GO:0048265 9.54 CRH TSPO
8 adrenal gland development GO:0030325 9.52 CRH TSPO
9 neuropeptide signaling pathway GO:0007218 9.5 OPRM1 PDYN POMC
10 regulation of NMDA receptor activity GO:2000310 9.49 CRH OPRM1
11 response to corticosterone GO:0051412 9.48 CRH FOS
12 chemical synaptic transmission GO:0007268 9.46 CRH HTR7 OPRM1 PDYN
13 regulation of systemic arterial blood pressure GO:0003073 9.43 AR KLK3
14 regulation of synaptic transmission, GABAergic GO:0032228 9.4 CNR1 NISCH
15 sensory perception GO:0007600 9.37 OPRM1 PDYN
16 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.13 CNR1 HTR7 OPRM1
17 response to cocaine GO:0042220 8.8 CNR1 CRH OPRM1
18 signal transduction GO:0007165 10.05 AR CNR1 CRH HTR7 OPRM1 POMC

Molecular functions related to Withdrawal Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 androgen binding GO:0005497 8.96 AR TSPO
2 neuropeptide hormone activity GO:0005184 8.8 CRH PDYN POMC

Sources for Withdrawal Disorder

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
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32 HPO
33 ICD10
34 ICD10 via Orphanet
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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