WPWS
MCID: WLF001
MIFTS: 63

Wolff-Parkinson-White Syndrome (WPWS)

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

MalaCards integrated aliases for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 57 12 53 25 75 29 13 55 6 44 15 73
Wolff-Parkinson-White Pattern 12 29 6 40
Wpw Syndrome 57 53 25
Ventricular Familial Preexcitation Syndrome 53 75
Anomalous Atrioventricular Excitation 12 73
Preexcitation Syndrome 53 73
Auriculoventricular Accessory Pathway Syndrome 53
Ventricular Pre-Excitation with Arrhythmia 25
Anomalous Ventricular Excitation Syndrome 53
False Bundle Branch Block Syndrome 53
Wolff-Parkinson-White Syndrome 37
Wolffparkinsonwhite Syndrome 76
Ventricular Preexcitation 73
Anomalous a-V Excitation 12
Wpws 75

Characteristics:

OMIM:

57
Inheritance:
? autosomal dominant factor


Classifications:



External Ids:

OMIM 57 194200
Disease Ontology 12 DOID:384
ICD10 33 I45.6
ICD9CM 35 426.7
MeSH 44 D014927
NCIt 50 C35132
SNOMED-CT 68 17869006 74390002
KEGG 37 H01154

Summaries for Wolff-Parkinson-White Syndrome

NIH Rare Diseases : 53 Wolff-Parkinson-White syndrome causes a problem with the rate or rhythm of the heartbeat (arrhythmia). People with the syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart. This leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. The most common arrhythmia associated with Wolff-Parkinson-White syndrome is paroxysmal supraventricular tachycardia. The syndrome is especially common in people of Chinese descent. In most cases, the cause of Wolff-Parkinson-White syndrome is unknown. A small percentage of cases are caused by genetic changes (mutations or pathogenic variants) in the PRKAG2 gene. These cases appear to be inherited in an autosomal dominant manner. A diagnosis of the syndrome is based on an electrocardiogram (ECG) or Holter test that shows episodes of tachycardia. Treatment for the syndrome may depend on the severity of symptoms but can include medications or surgery.

MalaCards based summary : Wolff-Parkinson-White Syndrome, also known as wolff-parkinson-white pattern, is related to cardiomyopathy, familial hypertrophic, 6 and hypertrophic cardiomyopathy. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways/superpathways are Insulin signaling pathway and Adipocytokine signaling pathway. The drugs Adenosine and Digoxin have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and atrioventricular node, and related phenotypes are sudden cardiac death and cardiomyopathy

Genetics Home Reference : 25 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

UniProtKB/Swiss-Prot : 75 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Wikipedia : 76 Wolff�??Parkinson�??White syndrome (WPWS) is a disorder due to a specific type of problem with the... more...

Description from OMIM: 194200

Related Diseases for Wolff-Parkinson-White Syndrome

Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 114)
# Related Disease Score Top Affiliating Genes
1 cardiomyopathy, familial hypertrophic, 6 33.3 PRKAG2 TNNI3
2 hypertrophic cardiomyopathy 30.7 LAMP2 MYH7 PRKAG2 TNNI3 TNNT1
3 cardiac arrest 30.5 KCNQ1 MYH7 NPPB
4 atrial heart septal defect 30.5 NKX2-5 TBX20 TNNI3
5 cardiomyopathy, familial hypertrophic, 1 30.4 MYH7 TNNI3 TNNT1
6 atrioventricular block 30.4 KCNQ1 NKX2-5 NPPB
7 atrial standstill 1 30.1 LAMP2 MYH7 NPPB PRKAG2 TNNI3
8 dilated cardiomyopathy 29.7 KCNQ1 LAMP2 MYH7 NKX2-5 NPPB PRKAG2
9 heart disease 29.6 CBS JAG1 KCNQ1 MYH7 NKX2-5 NPPB
10 cardiomyopathy, infantile histiocytoid 11.5
11 20p12.3 microdeletion syndrome 11.5
12 atrial fibrillation 11.2
13 myoclonic epilepsy associated with ragged-red fibers 11.1
14 myocardial infarction 10.9
15 ventricular fibrillation, paroxysmal familial, 1 10.8
16 progressive familial heart block, type ia 10.7
17 syncope 10.7
18 progressive familial heart block, type ib 10.6
19 brugada syndrome 10.6
20 right bundle branch block 10.6
21 tuberous sclerosis 10.6
22 cardiac conduction defect 10.5
23 orthostatic intolerance 10.5
24 acute myocardial infarction 10.5
25 myocarditis 10.4
26 muscular dystrophy 10.4
27 depression 10.4
28 rheumatic fever-related antigen 10.3
29 asthma 10.3
30 tricuspid atresia 10.3
31 congestive heart failure 10.3
32 left bundle branch hemiblock 10.3
33 endocarditis 10.3
34 rheumatic fever 10.3
35 epilepsy 10.3
36 optic nerve disease 10.3
37 lactic acidosis 10.3
38 neuropathy 10.3
39 dextrocardia 10.3
40 double discordia 10.3
41 transposition of the great arteries 10.3
42 encephalopathy 10.3
43 glycogen storage disease of heart, lethal congenital 10.2 PRKAG2 PRKAG2-AS1
44 ciliary dyskinesia, primary, 2 10.2 DNAAF3 TNNI3
45 spondyloarthropathy 1 10.2
46 total anomalous pulmonary venous return 1 10.2
47 alagille syndrome 1 10.2
48 pectus excavatum 10.2
49 hypokalemic periodic paralysis, type 1 10.2
50 pheochromocytoma 10.2

Comorbidity relations with Wolff-Parkinson-White Syndrome via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to Wolff-Parkinson-White Syndrome

Symptoms & Phenotypes for Wolff-Parkinson-White Syndrome

Symptoms via clinical synopsis from OMIM:

57
Cardiac:
palpitations
short pr interval and prolonged qrs, with slurred-up stroke of the r wave (delta wave) on ekg
paroxysmal supraventricular tachycardia
paroxysmal atrial fibrillation
familial cardiomyopathy
more

Clinical features from OMIM:

194200

Human phenotypes related to Wolff-Parkinson-White Syndrome:

32 (show all 10)
# Description HPO Frequency HPO Source Accession
1 sudden cardiac death 32 HP:0001645
2 cardiomyopathy 32 HP:0001638
3 wolff-parkinson-white syndrome 32 HP:0001716
4 stroke 32 HP:0001297
5 palpitations 32 HP:0001962
6 shortened pr interval 32 HP:0005165
7 paroxysmal supraventricular tachycardia 32 HP:0004763
8 paroxysmal atrial fibrillation 32 HP:0004757
9 prolonged qrs complex 32 HP:0006677
10 ventricular preexcitation with multiple accessory pathways 32 HP:0006684

MGI Mouse Phenotypes related to Wolff-Parkinson-White Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 BMP2 COL5A1 DNAAF3 JAG1 KCNQ1 LAMP2
2 growth/size/body region MP:0005378 9.7 BMP2 COL5A1 DNAAF3 JAG1 KCNQ1 LAMP2
3 muscle MP:0005369 9.36 JAG1 KCNQ1 LAMP2 MYH7 NKX2-5 PRKAA1

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

Drugs for Wolff-Parkinson-White Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational 58-61-7 60961
2
Digoxin Approved 20830-75-5 30322 2724385
3
Propranolol Approved, Investigational 525-66-6 4946
4
Procainamide Approved 51-06-9 4913
5
Amiodarone Approved, Investigational 1951-25-3 2157
6 Vasodilator Agents
7 Analgesics
8 Antihypertensive Agents
9 Adrenergic Agents
10 Potassium Channel Blockers
11 Cytochrome P-450 CYP2C9 Inhibitors
12 Diuretics, Potassium Sparing
13 Peripheral Nervous System Agents
14 Cytochrome P-450 CYP1A2 Inhibitors
15 Sodium Channel Blockers
16 Cardiotonic Agents
17 Cytochrome P-450 CYP2D6 Inhibitors
18 Cytochrome P-450 CYP3A Inhibitors
19 Adrenergic Antagonists
20 Adrenergic beta-Antagonists
21 Neurotransmitter Agents
22 Anti-Arrhythmia Agents
23 Cytochrome P-450 Enzyme Inhibitors
24 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Safety, Tolerability and Efficacy of BAF312 Given Orally in Patients With Relapsing-remitting Multiple Sclerosis Completed NCT01185821 Phase 2 BAF312
2 Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECG Completed NCT00251121 Not Applicable
3 Risk Assessment in Patients With Symptomatic- and Asymptomatic Preexcitation Recruiting NCT03301935
4 Stress ECG Test for the Evaluation of the Risk of Sudden Cardiac Death in a Paediatric Cohort With WPW Pattern Enrolling by invitation NCT03207373 Not Applicable
5 Management of Supraventricular Tachycardia of Children Not yet recruiting NCT03528616 adenosine,Propranolol,flecainide, amiodarone, propranolol, digoxin and procainamide.
6 Left Atrial Appendage Closure in Combination With Catheter Ablation Not yet recruiting NCT03788941
7 Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory Duct Terminated NCT00873470 Not Applicable

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

Genetic tests related to Wolff-Parkinson-White Syndrome:

# Genetic test Affiliating Genes
1 Wolff-Parkinson-White Pattern 29 PRKAG2
2 Wolff-Parkinson-White Syndrome 29

Anatomical Context for Wolff-Parkinson-White Syndrome

MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

41
Heart, Testes, Atrioventricular Node, Thyroid, Brain, Spinal Cord, Placenta

Publications for Wolff-Parkinson-White Syndrome

Articles related to Wolff-Parkinson-White Syndrome:

(show top 50) (show all 1086)
# Title Authors Year
1
A case of Wolff-Parkinson-White syndrome presenting spontaneous mutual frequent transition between atrioventricular reciprocating tachycardia and atrioventricular nodal re-entrant tachycardia. ( 29478804 )
2018
2
Pharmacologic therapy with flecainide for asymptomatic Wolff-Parkinson-White syndrome in an infant with severe left ventricular dyssynchrony. ( 29848398 )
2018
3
Molecular Pathogenesis of Familial Wolff-Parkinson-White Syndrome. ( 29593177 )
2018
4
Complications of Radiofrequency Ablation for Supraventricular Tachycardia in the Wolff-Parkinson-White Syndrome Associated With Noncompaction Cardiomyopathy. ( 29706203 )
2018
5
Isolated Wolff-Parkinson-White syndrome in identical twins. ( 29755940 )
2018
6
Wolff-Parkinson-White Syndrome in a Patient with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Syndrome Mimicking Juvenile Myoclonic Epilepsy. ( 29629547 )
2018
7
Wolff-Parkinson-White syndrome and noncompaction in Leber's hereditary optic neuropathy due to the variant m.3460G>A. ( 29562793 )
2018
8
Late restored cardiac function after successful resynchronization by right posterior accessory pathway ablation in Wolff-Parkinson-White syndrome associated dilated cardiomyopathy. ( 29452709 )
2018
9
Electrophysiological effects of desflurane in children with Wolff-Parkinson-White syndrome: a randomized crossover study. ( 29068040 )
2018
10
MY APPROACH to the Athlete With Wolff-Parkinson-White Syndrome (WPW). ( 29032933 )
2018
11
Acute myocardial infarction in a patient with Wolff-Parkinson-White syndrome. ( 30344545 )
2018
12
Prognostic Significance and Risk of Atrial Fibrillation of Wolff-Parkinson-White Syndrome in Patients With Hypertrophic Cardiomyopathy. ( 30201118 )
2018
13
Wolff-Parkinson White syndrome in a parturient with rheumatic heart disease for caesarean section - Anaesthesia management. ( 30166666 )
2018
14
Masking of myocardial infarction ECG in a patient with Wolff-Parkinson-White syndrome. ( 30386861 )
2018
15
Wolff-Parkinson-White syndrome presenting with steroid-induced bradycardia in a patient with acute rheumatic fever. ( 30070198 )
2018
16
Supraventricular tachycardia in a trauma patient masquerading as a Wolff-Parkinson-White syndrome. ( 28927735 )
2018
17
Epicardial Intraoperative Three-Dimensional Mapping of Wolff-Parkinson-White Syndrome in a Child With Ebstein's Anomaly. ( 29730348 )
2018
18
Altered myocardial characteristics of the preexcited segment in Wolff-Parkinson-White syndrome: A pilot study with cardiac magnetic resonance imaging. ( 29856866 )
2018
19
Delta wave notching time is associated with accessory pathway localization in patients with Wolff-Parkinson-White syndrome. ( 30014371 )
2018
20
Antidromic Atrioventricular Reentry Tachycardia with Wolff Parkinson White Syndrome: A Rare Beast. ( 30034964 )
2018
21
Life-Threatening Event Risk in Children With Wolff-Parkinson-White Syndrome: A Multicenter International Study. ( 30067481 )
2018
22
Fast, Broad, and Irregular: Wolff-Parkinson-White Syndrome. ( 30102907 )
2018
23
Three-dimensional histologic reconstruction of remnant functional accessory atrioventricular myocardial connections in a case of Wolff-Parkinson-White syndrome. ( 30121003 )
2018
24
The coexistence of Wolff-Parkinson-White syndrome (WPW) and atrioventricular nodal reentrant tachycardia (AVNRT). ( 30191196 )
2018
25
Accessory pathway-related left ventricular wall motion abnormality and the effects of radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome. ( 30255617 )
2018
26
Wolff-Parkinson-White syndrome due to a left atrial appendage-to-left ventricular connection: A case of a successful pathway elimination from inside of the left atrial appendage. ( 30479950 )
2018
27
Rheumatic Mitral Stenosis with Incidental Wolff-Parkinson-White Syndrome: A Rare Association. Treated by Percutaneous Transmitral Commissurotomy and Radiofrequency Ablation. ( 30505396 )
2018
28
Wolff-Parkinson-White pattern unmasked by severe musculoskeletal pain. ( 30004382 )
2018
29
Characterisation of three-dimensional mapping in Wolff-Parkinson-White syndrome with septal aneurysmal dyskinesis. ( 28847328 )
2017
30
Radiofrequency ablation of accessory pathways in patients with the Wolff-Parkinson-White syndrome: long-term risk of mortality and coronary events. ( 28605443 )
2017
31
Wolff-Parkinson-White Syndrome Associated With a Fistula Between the Right Atrial Appendage and Right Ventricle. ( 28214246 )
2017
32
Reversal of Wolff-Parkinson-White Syndrome induced dilated cardiomyopathy via resynchronization and subsequent accessory pathway ablation. ( 29238369 )
2017
33
A Case of Multiple Cardiovascular and Tracheal Anomalies Presented with Wolff-Parkinson-White Syndrome in a Middle-aged Adult. ( 29115093 )
2017
34
Accessory pathway location affects brain natriuretic peptide level in patients with Wolff-Parkinson-White syndrome. ( 27815796 )
2017
35
Wolff-Parkinson-White syndrome: lessons learnt and lessons remaining. ( 28084962 )
2017
36
Wolff-Parkinson-White Syndrome with Ventricular Hypertrophy in a Brazilian Family. ( 28690312 )
2017
37
Successful ablation of a right atrium-axillary ventricular accessory pathway associated with Wolff-Parkinson-White syndrome. ( 28543607 )
2017
38
Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome. ( 28491758 )
2017
39
The impact of left ventricular deformation and dyssynchrony on improvement of left ventricular ejection fraction following radiofrequency catheter ablation in Wolff-Parkinson-White syndrome: A comprehensive study by speckle tracking echocardiography. ( 28929532 )
2017
40
A case of Type-C Wolff-Parkinson-White syndrome with severe left ventricular dysfunction: Efficacy of catheter ablation. ( 30524579 )
2017
41
Long term risk of Wolff-Parkinson-White pattern and syndrome. ( 28108086 )
2017
42
Editorial commentary: Wolff-Parkinson-White pattern and syndrome: Where do we stand in 2017? ( 28242044 )
2017
43
Transesophageal and invasive electrophysiologic evaluation in children with Wolff-Parkinson-White pattern. ( 28436586 )
2017
44
The use of sugammadex in a pregnant patient with Wolff-Parkinson-White syndrome. ( 27555124 )
2016
45
Spinal Anaesthesia is Safe in a Patient with Wolff-Parkinson-White Syndrome Undergoing Evacuation of Molar Pregnancy. ( 27042562 )
2016
46
The Wolff-Parkinson-White Syndrome: A Test Bed for the Assessment of Myocardial Dyssynchrony? ( 27307557 )
2016
47
The impact of B-type natriuretic peptide levels on the suppression of accompanying atrial fibrillation in Wolff-Parkinson-White syndrome patients after accessory pathway ablation. ( 26917195 )
2016
48
Wolff-Parkinson-White Syndrome: A Stepwise Deterioration to Sudden Death. ( 26719390 )
2016
49
Tachyarrhythmia in Wolff-Parkinson-White Syndrome. ( 27429700 )
2016
50
Physiological Expression of AMPKI^2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice. ( 27621313 )
2016

Variations for Wolff-Parkinson-White Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

75
# Symbol AA change Variation ID SNP ID
1 PRKAG2 p.Arg302Gln VAR_013264 rs121908987
2 PRKAG2 p.Arg531Gly VAR_032909 rs121908990

ClinVar genetic disease variations for Wolff-Parkinson-White Syndrome:

6 (show top 50) (show all 308)
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC26A4 NM_000441.1(SLC26A4): c.85G> C (p.Glu29Gln) single nucleotide variant Pathogenic/Likely pathogenic rs111033205 GRCh37 Chromosome 7, 107302171: 107302171
2 SLC26A4 NM_000441.1(SLC26A4): c.85G> C (p.Glu29Gln) single nucleotide variant Pathogenic/Likely pathogenic rs111033205 GRCh38 Chromosome 7, 107661726: 107661726
3 PRKAG2 NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln) single nucleotide variant Pathogenic rs121908987 GRCh37 Chromosome 7, 151273498: 151273498
4 PRKAG2 NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln) single nucleotide variant Pathogenic rs121908987 GRCh38 Chromosome 7, 151576412: 151576412
5 NODAL NM_018055.4(NODAL): c.778G> A (p.Gly260Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs121909283 GRCh37 Chromosome 10, 72195155: 72195155
6 NODAL NM_018055.4(NODAL): c.778G> A (p.Gly260Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs121909283 GRCh38 Chromosome 10, 70435399: 70435399
7 MYH7 NM_000257.3(MYH7): c.728G> A (p.Arg243His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606910 GRCh37 Chromosome 14, 23900798: 23900798
8 MYH7 NM_000257.3(MYH7): c.728G> A (p.Arg243His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606910 GRCh38 Chromosome 14, 23431589: 23431589
9 MYH6 NM_002471.3(MYH6): c.3010G> T (p.Ala1004Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs143978652 GRCh37 Chromosome 14, 23862646: 23862646
10 MYH6 NM_002471.3(MYH6): c.3010G> T (p.Ala1004Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs143978652 GRCh38 Chromosome 14, 23393437: 23393437
11 MYBPC3 NM_000256.3(MYBPC3): c.1321G> A (p.Glu441Lys) single nucleotide variant Uncertain significance rs193922377 GRCh37 Chromosome 11, 47364602: 47364602
12 MYBPC3 NM_000256.3(MYBPC3): c.1321G> A (p.Glu441Lys) single nucleotide variant Uncertain significance rs193922377 GRCh38 Chromosome 11, 47343051: 47343051
13 PRKAG2 NM_016203.3(PRKAG2): c.1593G> A (p.Arg531=) single nucleotide variant Conflicting interpretations of pathogenicity rs148197254 GRCh37 Chromosome 7, 151257695: 151257695
14 PRKAG2 NM_016203.3(PRKAG2): c.1593G> A (p.Arg531=) single nucleotide variant Conflicting interpretations of pathogenicity rs148197254 GRCh38 Chromosome 7, 151560609: 151560609
15 PRKAG2 NM_016203.3(PRKAG2): c.298G> A (p.Gly100Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs79474211 GRCh37 Chromosome 7, 151478406: 151478406
16 PRKAG2 NM_016203.3(PRKAG2): c.298G> A (p.Gly100Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs79474211 GRCh38 Chromosome 7, 151781320: 151781320
17 MYH7 NM_000257.3(MYH7): c.2389G> A (p.Ala797Thr) single nucleotide variant Pathogenic/Likely pathogenic rs3218716 GRCh37 Chromosome 14, 23894525: 23894525
18 MYH7 NM_000257.3(MYH7): c.2389G> A (p.Ala797Thr) single nucleotide variant Pathogenic/Likely pathogenic rs3218716 GRCh38 Chromosome 14, 23425316: 23425316
19 MYH7 NM_000257.3(MYH7): c.4377G> T (p.Lys1459Asn) single nucleotide variant Likely benign rs201307101 GRCh37 Chromosome 14, 23886504: 23886504
20 MYH7 NM_000257.3(MYH7): c.4377G> T (p.Lys1459Asn) single nucleotide variant Likely benign rs201307101 GRCh38 Chromosome 14, 23417295: 23417295
21 PRKAG2 NM_016203.3(PRKAG2): c.*3G> A single nucleotide variant Benign/Likely benign rs113234987 GRCh37 Chromosome 7, 151254284: 151254284
22 PRKAG2 NM_016203.3(PRKAG2): c.*3G> A single nucleotide variant Benign/Likely benign rs113234987 GRCh38 Chromosome 7, 151557198: 151557198
23 PRKAG2 NM_016203.3(PRKAG2): c.111T> A (p.Ile37=) single nucleotide variant Conflicting interpretations of pathogenicity rs144426409 GRCh37 Chromosome 7, 151573595: 151573595
24 PRKAG2 NM_016203.3(PRKAG2): c.111T> A (p.Ile37=) single nucleotide variant Conflicting interpretations of pathogenicity rs144426409 GRCh38 Chromosome 7, 151876510: 151876510
25 PRKAG2 NM_016203.3(PRKAG2): c.114+12C> T single nucleotide variant Benign/Likely benign rs77902041 GRCh37 Chromosome 7, 151573580: 151573580
26 PRKAG2 NM_016203.3(PRKAG2): c.114+12C> T single nucleotide variant Benign/Likely benign rs77902041 GRCh38 Chromosome 7, 151876495: 151876495
27 PRKAG2 NM_016203.3(PRKAG2): c.123C> T (p.Ser41=) single nucleotide variant Conflicting interpretations of pathogenicity rs397517263 GRCh37 Chromosome 7, 151483619: 151483619
28 PRKAG2 NM_016203.3(PRKAG2): c.123C> T (p.Ser41=) single nucleotide variant Conflicting interpretations of pathogenicity rs397517263 GRCh38 Chromosome 7, 151786533: 151786533
29 KCNQ1 NM_000218.2(KCNQ1): c.1189C> T (p.Arg397Trp) single nucleotide variant Conflicting interpretations of pathogenicity rs199472776 GRCh37 Chromosome 11, 2608860: 2608860
30 KCNQ1 NM_000218.2(KCNQ1): c.1189C> T (p.Arg397Trp) single nucleotide variant Conflicting interpretations of pathogenicity rs199472776 GRCh38 Chromosome 11, 2587630: 2587630
31 KCNQ1 NM_000218.2(KCNQ1): c.724G> A (p.Asp242Asn) single nucleotide variant Pathogenic/Likely pathogenic rs199472712 GRCh37 Chromosome 11, 2593283: 2593283
32 KCNQ1 NM_000218.2(KCNQ1): c.724G> A (p.Asp242Asn) single nucleotide variant Pathogenic/Likely pathogenic rs199472712 GRCh38 Chromosome 11, 2572053: 2572053
33 KCNQ1 NM_000218.2(KCNQ1): c.1621G> A (p.Val541Ile) single nucleotide variant Uncertain significance rs199472796 GRCh37 Chromosome 11, 2797220: 2797220
34 KCNQ1 NM_000218.2(KCNQ1): c.1621G> A (p.Val541Ile) single nucleotide variant Uncertain significance rs199472796 GRCh38 Chromosome 11, 2775990: 2775990
35 SCN5A NM_198056.2(SCN5A): c.1567C> T (p.Arg523Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs199473119 GRCh37 Chromosome 3, 38645526: 38645526
36 SCN5A NM_198056.2(SCN5A): c.1567C> T (p.Arg523Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs199473119 GRCh38 Chromosome 3, 38604035: 38604035
37 RYR2 NM_001035.2(RYR2): c.982G> A (p.Ala328Thr) single nucleotide variant Uncertain significance rs201669522 GRCh37 Chromosome 1, 237586525: 237586525
38 RYR2 NM_001035.2(RYR2): c.982G> A (p.Ala328Thr) single nucleotide variant Uncertain significance rs201669522 GRCh38 Chromosome 1, 237423225: 237423225
39 PRKAG2 NM_016203.3(PRKAG2): c.202G> A (p.Gly68Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs730880970 GRCh38 Chromosome 7, 151781416: 151781416
40 PRKAG2 NM_016203.3(PRKAG2): c.202G> A (p.Gly68Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs730880970 GRCh37 Chromosome 7, 151478502: 151478502
41 CACNA1C NM_000719.6(CACNA1C): c.1485C> A (p.His495Gln) single nucleotide variant Uncertain significance rs373335068 GRCh37 Chromosome 12, 2666120: 2666120
42 CACNA1C NM_000719.6(CACNA1C): c.1485C> A (p.His495Gln) single nucleotide variant Uncertain significance rs373335068 GRCh38 Chromosome 12, 2556954: 2556954
43 CACNA1C NM_001129842.1(CACNA1C): c.2579G> A (p.Arg860Gln) single nucleotide variant Uncertain significance rs730880056 GRCh37 Chromosome 12, 2702427: 2702427
44 CACNA1C NM_001129842.1(CACNA1C): c.2579G> A (p.Arg860Gln) single nucleotide variant Uncertain significance rs730880056 GRCh38 Chromosome 12, 2593261: 2593261
45 SNTA1 NM_003098.2(SNTA1): c.1088A> C (p.Glu363Ala) single nucleotide variant Uncertain significance rs147964932 GRCh37 Chromosome 20, 31998090: 31998090
46 SNTA1 NM_003098.2(SNTA1): c.1088A> C (p.Glu363Ala) single nucleotide variant Uncertain significance rs147964932 GRCh38 Chromosome 20, 33410284: 33410284
47 RYR2 NM_001035.2(RYR2): c.11919T> G (p.Asp3973Glu) single nucleotide variant Uncertain significance rs370103782 GRCh37 Chromosome 1, 237944903: 237944903
48 RYR2 NM_001035.2(RYR2): c.11919T> G (p.Asp3973Glu) single nucleotide variant Uncertain significance rs370103782 GRCh38 Chromosome 1, 237781603: 237781603
49 SCN5A NM_198056.2(SCN5A): c.1705C> G (p.Arg569Gly) single nucleotide variant Uncertain significance rs199473576 GRCh37 Chromosome 3, 38645388: 38645388
50 SCN5A NM_198056.2(SCN5A): c.1705C> G (p.Arg569Gly) single nucleotide variant Uncertain significance rs199473576 GRCh38 Chromosome 3, 38603897: 38603897

Expression for Wolff-Parkinson-White Syndrome

Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for Wolff-Parkinson-White Syndrome

Pathways related to Wolff-Parkinson-White Syndrome according to KEGG:

37
# Name Kegg Source Accession
1 Insulin signaling pathway hsa04910
2 Adipocytokine signaling pathway hsa04920
3 Hypertrophic cardiomyopathy (HCM) hsa05410

Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 MYH7 NPPB PRKAA1 PRKAA2 PRKAG2 PRKAG3
2
Show member pathways
12.42 PRKAA1 PRKAA2 PRKAG2 PRKAG3
3 12.42 CBS PRKAA1 PRKAA2 PRKAG2 PRKAG3
4
Show member pathways
12.37 BMP2 MYH7 NKX2-5 NPPB
5
Show member pathways
12.34 PRKAA1 PRKAA2 PRKAG2 PRKAG3
6
Show member pathways
12.32 PRKAA1 PRKAA2 PRKAG2 PRKAG3
7
Show member pathways
12.13 PRKAA1 PRKAA2 PRKAG2 PRKAG3
8 12.12 PRKAA1 PRKAA2 PRKAG2 PRKAG3
9
Show member pathways
12.08 PRKAA1 PRKAA2 PRKAG2 PRKAG3
10
Show member pathways
12.05 PRKAA1 PRKAA2 PRKAG2 PRKAG3
11
Show member pathways
12.03 PRKAA1 PRKAA2 PRKAG2 PRKAG3
12
Show member pathways
11.99 PRKAA1 PRKAA2 PRKAG2 PRKAG3
13 11.92 LAMP2 PRKAA1 PRKAA2
14
Show member pathways
11.86 PRKAA1 PRKAA2 PRKAG2 PRKAG3
15 11.86 JAG1 PRKAA1 PRKAA2 PRKAG2 PRKAG3
16 11.82 PRKAA1 PRKAA2 PRKAG2 PRKAG3
17 11.71 PRKAA1 PRKAA2 PRKAG2 PRKAG3
18
Show member pathways
11.67 MYH7 PRKAA1 PRKAA2 PRKAG2 PRKAG3 TNNI3
19 11.62 PRKAA1 PRKAA2 PRKAG2 PRKAG3
20 11.57 PRKAA1 PRKAA2 PRKAG2 PRKAG3
21 11.51 NKX2-5 TBX20 TNNI3
22 11.5 MYH7 PRKAA2 PRKAG2 PRKAG3
23 11.42 BMP2 NKX2-5 TBX20
24 11.39 PRKAA1 PRKAA2 PRKAG2 PRKAG3
25
Show member pathways
11.19 PRKAA1 PRKAA2 PRKAG2 PRKAG3
26 11.01 PRKAA1 PRKAA2 PRKAG2 PRKAG3
27 10.65 PRKAA2 PRKAG2
28 10.27 BMP2 MYH7 NKX2-5 NPPB

GO Terms for Wolff-Parkinson-White Syndrome

Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin complex GO:0005861 8.96 TNNI3 TNNT1
2 nucleotide-activated protein kinase complex GO:0031588 8.92 PRKAA1 PRKAA2 PRKAG2 PRKAG3

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 fatty acid metabolic process GO:0006631 9.83 PRKAA1 PRKAA2 PRKAG2 PRKAG3
2 cell cycle arrest GO:0007050 9.8 PRKAA1 PRKAA2 PRKAG2 PRKAG3
3 inner ear development GO:0048839 9.73 BMP2 JAG1 KCNQ1
4 muscle contraction GO:0006936 9.73 MYH7 TBX20 TNNI3 TNNT1
5 aortic valve morphogenesis GO:0003180 9.67 JAG1 TBX20
6 embryonic heart tube development GO:0035050 9.66 NKX2-5 TBX20
7 lipid biosynthetic process GO:0008610 9.65 PRKAA1 PRKAA2
8 positive regulation of glycolytic process GO:0045821 9.65 PRKAA1 PRKAA2
9 regulation of muscle contraction GO:0006937 9.65 TNNI3 TNNT1
10 muscle filament sliding GO:0030049 9.65 MYH7 TNNI3 TNNT1
11 cardiovascular system development GO:0072358 9.64 KCNQ1 NKX2-5
12 cellular response to prostaglandin E stimulus GO:0071380 9.64 PRKAA1 PRKAA2
13 endocardial cushion morphogenesis GO:0003203 9.63 BMP2 TBX20
14 fatty acid homeostasis GO:0055089 9.63 PRKAA1 PRKAA2
15 sterol biosynthetic process GO:0016126 9.63 PRKAA1 PRKAA2 PRKAG2
16 striated muscle contraction GO:0006941 9.62 MYH7 TNNI3
17 adult heart development GO:0007512 9.62 MYH7 NKX2-5
18 heart contraction GO:0060047 9.61 NKX2-5 TNNI3
19 cardiac right ventricle morphogenesis GO:0003215 9.61 JAG1 TBX20
20 atrial septum morphogenesis GO:0060413 9.6 NKX2-5 TBX20
21 cellular response to nutrient levels GO:0031669 9.59 PRKAA1 PRKAA2
22 transition between fast and slow fiber GO:0014883 9.58 MYH7 TNNT1
23 regulation of fatty acid biosynthetic process GO:0042304 9.58 PRKAA2 PRKAG2
24 positive regulation of cellular protein localization GO:1903829 9.57 PRKAA1 PRKAA2
25 macroautophagy GO:0016236 9.56 PRKAA1 PRKAA2 PRKAG2 PRKAG3
26 negative regulation of tubulin deacetylation GO:1904428 9.55 PRKAA1 PRKAA2
27 regulation of protein serine/threonine kinase activity GO:0071900 9.54 PRKAG2 PRKAG3
28 histone-serine phosphorylation GO:0035404 9.51 PRKAA1 PRKAA2
29 skeletal muscle contraction GO:0003009 9.5 MYH7 TNNI3 TNNT1
30 positive regulation of peptidyl-lysine acetylation GO:2000758 9.4 PRKAA1 PRKAA2
31 regulation of stress granule assembly GO:0062028 9.37 PRKAA1 PRKAA2
32 cardiac muscle tissue morphogenesis GO:0055008 9.33 BMP2 NKX2-5 TBX20
33 fatty acid biosynthetic process GO:0006633 9.26 PRKAA1 PRKAA2 PRKAG2 PRKAG3
34 cardiac muscle contraction GO:0060048 9.02 KCNQ1 MYH7 NKX2-5 TNNI3 TNNT1
35 protein phosphorylation GO:0006468 10.06 BMP2 PRKAA1 PRKAA2 PRKAG2 PRKAG3

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone serine kinase activity GO:0035174 9.37 PRKAA1 PRKAA2
2 adenyl ribonucleotide binding GO:0032559 9.32 PRKAG2 PRKAG3
3 troponin T binding GO:0031014 9.26 TNNI3 TNNT1
4 [acetyl-CoA carboxylase] kinase activity GO:0050405 9.16 PRKAA1 PRKAA2
5 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity GO:0047322 8.96 PRKAA1 PRKAA2
6 AMP-activated protein kinase activity GO:0004679 8.92 PRKAA1 PRKAA2 PRKAG2 PRKAG3

Sources for Wolff-Parkinson-White Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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