WPWS
MCID: WLF001
MIFTS: 63

Wolff-Parkinson-White Syndrome (WPWS)

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

MalaCards integrated aliases for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 58 12 77 54 26 76 30 13 56 6 45 15 17 74
Wolff-Parkinson-White Pattern 12 30 6 41
Wpw Syndrome 58 54 26
Ventricular Familial Preexcitation Syndrome 54 76
Anomalous Atrioventricular Excitation 12 74
Preexcitation Syndrome 54 74
Auriculoventricular Accessory Pathway Syndrome 54
Ventricular Pre-Excitation with Arrhythmia 26
Anomalous Ventricular Excitation Syndrome 54
False Bundle Branch Block Syndrome 54
Wolff-Parkinson-White Syndrome 38
Ventricular Preexcitation 74
Anomalous a-V Excitation 12
Wpws 76

Characteristics:

OMIM:

58
Inheritance:
? autosomal dominant factor


Classifications:



External Ids:

Disease Ontology 12 DOID:384
OMIM 58 194200
KEGG 38 H01154
ICD9CM 36 426.7
MeSH 45 D014927
NCIt 51 C35132
SNOMED-CT 69 17869006 74390002
ICD10 34 I45.6

Summaries for Wolff-Parkinson-White Syndrome

NIH Rare Diseases : 54 Wolff-Parkinson-White syndrome causes a problem with the rate or rhythm of the heartbeat (arrhythmia). People with the syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart. This leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. The most common arrhythmia associated with Wolff-Parkinson-White syndrome is paroxysmal supraventricular tachycardia. The syndrome is especially common in people of Chinese descent. In most cases, the cause of Wolff-Parkinson-White syndrome is unknown. A small percentage of cases are caused by genetic changes (mutations or pathogenic variants) in the PRKAG2 gene. These cases appear to be inherited in an autosomal dominant manner. A diagnosis of the syndrome is based on an electrocardiogram (ECG) or Holter test that shows episodes of tachycardia. Treatment for the syndrome may depend on the severity of symptoms but can include medications or surgery.

MalaCards based summary : Wolff-Parkinson-White Syndrome, also known as wolff-parkinson-white pattern, is related to cardiomyopathy, familial hypertrophic, 6 and hypertrophic cardiomyopathy. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways/superpathways are Insulin signaling pathway and Adipocytokine signaling pathway. The drugs Propranolol and Procainamide have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and atrioventricular node, and related phenotypes are sudden cardiac death and cardiomyopathy

Genetics Home Reference : 26 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

UniProtKB/Swiss-Prot : 76 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Wikipedia : 77 Wolff–Parkinson–White syndrome (WPWS) is a disorder due to a specific type of problem with the... more...

Description from OMIM: 194200

Related Diseases for Wolff-Parkinson-White Syndrome

Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 cardiomyopathy, familial hypertrophic, 6 33.5 PRKAG2 TNNI3
2 hypertrophic cardiomyopathy 31.2 MYH7 PRKAG2 TNNI3 TNNT1
3 atrial standstill 1 31.1 MYH7 NPPB PRKAG2 TNNI3
4 atrioventricular block 30.8 KCNQ1 NKX2-5 NPPB
5 cardiomyopathy, familial hypertrophic, 1 30.6 MYH7 TNNI3 TNNT1
6 cardiac arrest 30.5 KCNQ1 MYH7 NPPB
7 ventricular septal defect 30.3 JAG1 MYH7 NKX2-5 NPPB
8 dilated cardiomyopathy 30.0 KCNQ1 MYH7 NKX2-5 NPPB PRKAG2 TBX20
9 heart disease 29.9 CBS JAG1 KCNQ1 MYH7 NKX2-5 NPPB
10 cardiomyopathy, infantile histiocytoid 11.5
11 20p12.3 microdeletion syndrome 11.5
12 atrial fibrillation 11.2
13 myoclonic epilepsy associated with ragged-red fibers 11.1
14 myocardial infarction 11.0
15 ventricular fibrillation, paroxysmal familial, 1 10.9
16 progressive familial heart block, type ia 10.9
17 syncope 10.7
18 cardiac conduction defect 10.6
19 progressive familial heart block, type ib 10.6
20 acute myocardial infarction 10.6
21 brugada syndrome 10.6
22 right bundle branch block 10.6
23 tuberous sclerosis 10.6
24 depression 10.5
25 graves disease 1 10.5
26 orthostatic intolerance 10.5
27 left bundle branch hemiblock 10.5
28 myocarditis 10.5
29 muscular dystrophy 10.5
30 distal trisomy 9q 10.5
31 refractory anemia 10.5
32 endocarditis 10.4
33 epilepsy 10.4
34 aortic coarctation 10.4
35 double discordia 10.4
36 glycogen storage disease of heart, lethal congenital 10.4 PRKAG2 PRKAG2-AS1
37 rheumatic fever-related antigen 10.3
38 muscular dystrophy, duchenne type 10.3
39 asthma 10.3
40 tricuspid atresia 10.3
41 congestive heart failure 10.3
42 rheumatic fever 10.3
43 mitral valve stenosis 10.3
44 atrial heart septal defect 10.3
45 optic nerve disease 10.3
46 ischemia 10.3
47 lactic acidosis 10.3
48 hyperthyroidism 10.3
49 neuropathy 10.3
50 dextrocardia 10.3

Comorbidity relations with Wolff-Parkinson-White Syndrome via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to Wolff-Parkinson-White Syndrome

Symptoms & Phenotypes for Wolff-Parkinson-White Syndrome

Human phenotypes related to Wolff-Parkinson-White Syndrome:

33 (show all 10)
# Description HPO Frequency HPO Source Accession
1 sudden cardiac death 33 HP:0001645
2 cardiomyopathy 33 HP:0001638
3 wolff-parkinson-white syndrome 33 HP:0001716
4 stroke 33 HP:0001297
5 palpitations 33 HP:0001962
6 shortened pr interval 33 HP:0005165
7 paroxysmal supraventricular tachycardia 33 HP:0004763
8 paroxysmal atrial fibrillation 33 HP:0004757
9 prolonged qrs complex 33 HP:0006677
10 ventricular preexcitation with multiple accessory pathways 33 HP:0006684

Symptoms via clinical synopsis from OMIM:

58
Cardiac:
palpitations
short pr interval and prolonged qrs, with slurred-up stroke of the r wave (delta wave) on ekg
paroxysmal supraventricular tachycardia
paroxysmal atrial fibrillation
familial cardiomyopathy
more

Clinical features from OMIM:

194200

MGI Mouse Phenotypes related to Wolff-Parkinson-White Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 BMP2 COL5A1 DNAAF3 JAG1 KCNQ1 MYH7
2 hearing/vestibular/ear MP:0005377 9.43 BMP2 GJC3 JAG1 KCNQ1 PRKAA2 SLC26A4
3 muscle MP:0005369 9.32 JAG1 KCNQ1 MYH7 NKX2-5 PRKAA1 PRKAA2

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

Drugs for Wolff-Parkinson-White Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propranolol Approved, Investigational 525-66-6 4946
2
Procainamide Approved 51-06-9 4913
3
Adenosine Approved, Investigational 58-61-7 60961
4
Digoxin Approved 20830-75-5 30322 2724385
5
Amiodarone Approved, Investigational 1951-25-3 2157
6 Adrenergic Antagonists
7 Cytochrome P-450 Enzyme Inhibitors
8 Vasodilator Agents
9 Adrenergic beta-Antagonists
10 Peripheral Nervous System Agents
11 Cytochrome P-450 CYP3A Inhibitors
12 Anti-Arrhythmia Agents
13 Potassium Channel Blockers
14 Cytochrome P-450 CYP1A2 Inhibitors
15 Sodium Channel Blockers
16 Neurotransmitter Agents
17 Cardiotonic Agents
18 Cytochrome P-450 CYP2D6 Inhibitors
19 Adrenergic Agents
20 Analgesics
21 Antihypertensive Agents
22 Cytochrome P-450 CYP2C9 Inhibitors
23 Diuretics, Potassium Sparing
24 Protective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Safety, Tolerability and Efficacy of BAF312 Given Orally in Patients With Relapsing-remitting Multiple Sclerosis Completed NCT01185821 Phase 2 BAF312
2 Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECG Completed NCT00251121 Not Applicable
3 Risk Assessment in Patients With Symptomatic- and Asymptomatic Preexcitation Recruiting NCT03301935
4 Stress ECG Test for the Evaluation of the Risk of Sudden Cardiac Death in a Paediatric Cohort With WPW Pattern Enrolling by invitation NCT03207373 Not Applicable
5 Management of Supraventricular Tachycardia of Children Not yet recruiting NCT03528616 adenosine,Propranolol,flecainide, amiodarone, propranolol, digoxin and procainamide.
6 Left Atrial Appendage Closure in Combination With Catheter Ablation Not yet recruiting NCT03788941
7 Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory Duct Terminated NCT00873470 Not Applicable

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

Genetic tests related to Wolff-Parkinson-White Syndrome:

# Genetic test Affiliating Genes
1 Wolff-Parkinson-White Pattern 30 PRKAG2
2 Wolff-Parkinson-White Syndrome 30

Anatomical Context for Wolff-Parkinson-White Syndrome

MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

42
Testes, Heart, Atrioventricular Node, Thyroid, Brain, Kidney, Spinal Cord

Publications for Wolff-Parkinson-White Syndrome

Articles related to Wolff-Parkinson-White Syndrome:

(show top 50) (show all 1552)
# Title Authors Year
1
Syncope in a Patient With Wolff-Parkinson-White Pattern: Not All That Glitters Is Gold. ( 30715074 )
2019
2
Antipsychotics for patients with Wolff-Parkinson-White Syndrome. ( 30649911 )
2019
3
A case of Wolff-Parkinson-White syndrome presenting spontaneous mutual frequent transition between atrioventricular reciprocating tachycardia and atrioventricular nodal re-entrant tachycardia. ( 29478804 )
2018
4
Pharmacologic therapy with flecainide for asymptomatic Wolff-Parkinson-White syndrome in an infant with severe left ventricular dyssynchrony. ( 29848398 )
2018
5
Molecular Pathogenesis of Familial Wolff-Parkinson-White Syndrome. ( 29593177 )
2018
6
Complications of Radiofrequency Ablation for Supraventricular Tachycardia in the Wolff-Parkinson-White Syndrome Associated With Noncompaction Cardiomyopathy. ( 29706203 )
2018
7
Isolated Wolff-Parkinson-White syndrome in identical twins. ( 29755940 )
2018
8
Wolff-Parkinson-White Syndrome in a Patient with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Syndrome Mimicking Juvenile Myoclonic Epilepsy. ( 29629547 )
2018
9
Wolff-Parkinson-White syndrome and noncompaction in Leber's hereditary optic neuropathy due to the variant m.3460G>A. ( 29562793 )
2018
10
Late restored cardiac function after successful resynchronization by right posterior accessory pathway ablation in Wolff-Parkinson-White syndrome associated dilated cardiomyopathy. ( 29452709 )
2018
11
Electrophysiological effects of desflurane in children with Wolff-Parkinson-White syndrome: a randomized crossover study. ( 29068040 )
2018
12
MY APPROACH to the Athlete With Wolff-Parkinson-White Syndrome (WPW). ( 29032933 )
2018
13
Altered myocardial characteristics of the preexcited segment in Wolff-Parkinson-White syndrome: A pilot study with cardiac magnetic resonance imaging. ( 29856866 )
2018
14
Acute myocardial infarction in a patient with Wolff-Parkinson-White syndrome. ( 30344545 )
2018
15
Prognostic Significance and Risk of Atrial Fibrillation of Wolff-Parkinson-White Syndrome in Patients With Hypertrophic Cardiomyopathy. ( 30201118 )
2018
16
Wolff-Parkinson White syndrome in a parturient with rheumatic heart disease for caesarean section - Anaesthesia management. ( 30166666 )
2018
17
Aborted sudden cardiac death in a young soldier with concomitant hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome. ( 30585570 )
2018
18
Masking of myocardial infarction ECG in a patient with Wolff-Parkinson-White syndrome. ( 30386861 )
2018
19
Wolff-Parkinson-White syndrome presenting with steroid-induced bradycardia in a patient with acute rheumatic fever. ( 30070198 )
2018
20
Epicardial Intraoperative Three-Dimensional Mapping of Wolff-Parkinson-White Syndrome in a Child With Ebstein's Anomaly. ( 29730348 )
2018
21
Delta wave notching time is associated with accessory pathway localization in patients with Wolff-Parkinson-White syndrome. ( 30014371 )
2018
22
Antidromic Atrioventricular Reentry Tachycardia with Wolff Parkinson White Syndrome: A Rare Beast. ( 30034964 )
2018
23
Life-Threatening Event Risk in Children With Wolff-Parkinson-White Syndrome: A Multicenter International Study. ( 30067481 )
2018
24
Fast, Broad, and Irregular: Wolff-Parkinson-White Syndrome. ( 30102907 )
2018
25
Three-dimensional histologic reconstruction of remnant functional accessory atrioventricular myocardial connections in a case of Wolff-Parkinson-White syndrome. ( 30121003 )
2018
26
The coexistence of Wolff-Parkinson-White syndrome (WPW) and atrioventricular nodal reentrant tachycardia (AVNRT). ( 30191196 )
2018
27
Accessory pathway-related left ventricular wall motion abnormality and the effects of radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome. ( 30255617 )
2018
28
Wolff-Parkinson-White syndrome due to a left atrial appendage-to-left ventricular connection: A case of a successful pathway elimination from inside of the left atrial appendage. ( 30479950 )
2018
29
Rheumatic Mitral Stenosis with Incidental Wolff-Parkinson-White Syndrome: A Rare Association. Treated by Percutaneous Transmitral Commissurotomy and Radiofrequency Ablation. ( 30505396 )
2018
30
Sudden cardiac death due to the Wolff-Parkinson-White syndrome: A case report with genetic analysis. ( 30572429 )
2018
31
Spontaneous regression of submitral pseudoaneurysm after radiofrequency catheter ablation in a patient with Wolff-Parkinson-White syndrome. ( 30581737 )
2018
32
Wolff-Parkinson-White pattern unmasked by severe musculoskeletal pain. ( 30004382 )
2018
33
Characterisation of three-dimensional mapping in Wolff-Parkinson-White syndrome with septal aneurysmal dyskinesis. ( 28847328 )
2017
34
Radiofrequency ablation of accessory pathways in patients with the Wolff-Parkinson-White syndrome: long-term risk of mortality and coronary events. ( 28605443 )
2017
35
Wolff-Parkinson-White Syndrome Associated With a Fistula Between the Right Atrial Appendage and Right Ventricle. ( 28214246 )
2017
36
Reversal of Wolff-Parkinson-White Syndrome induced dilated cardiomyopathy via resynchronization and subsequent accessory pathway ablation. ( 29238369 )
2017
37
A Case of Multiple Cardiovascular and Tracheal Anomalies Presented with Wolff-Parkinson-White Syndrome in a Middle-aged Adult. ( 29115093 )
2017
38
Accessory pathway location affects brain natriuretic peptide level in patients with Wolff-Parkinson-White syndrome. ( 27815796 )
2017
39
Wolff-Parkinson-White syndrome: lessons learnt and lessons remaining. ( 28084962 )
2017
40
Wolff-Parkinson-White Syndrome with Ventricular Hypertrophy in a Brazilian Family. ( 28690312 )
2017
41
Successful ablation of a right atrium-axillary ventricular accessory pathway associated with Wolff-Parkinson-White syndrome. ( 28543607 )
2017
42
Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome. ( 28491758 )
2017
43
The impact of left ventricular deformation and dyssynchrony on improvement of left ventricular ejection fraction following radiofrequency catheter ablation in Wolff-Parkinson-White syndrome: A comprehensive study by speckle tracking echocardiography. ( 28929532 )
2017
44
Supraventricular tachycardia in a trauma patient masquerading as a Wolff-Parkinson-White syndrome. ( 28927735 )
2017
45
A case of Type-C Wolff-Parkinson-White syndrome with severe left ventricular dysfunction: Efficacy of catheter ablation. ( 30524579 )
2017
46
Long term risk of Wolff-Parkinson-White pattern and syndrome. ( 28108086 )
2017
47
Editorial commentary: Wolff-Parkinson-White pattern and syndrome: Where do we stand in 2017? ( 28242044 )
2017
48
Transesophageal and invasive electrophysiologic evaluation in children with Wolff-Parkinson-White pattern. ( 28436586 )
2017
49
The use of sugammadex in a pregnant patient with Wolff-Parkinson-White syndrome. ( 27555124 )
2016
50
Spinal Anaesthesia is Safe in a Patient with Wolff-Parkinson-White Syndrome Undergoing Evacuation of Molar Pregnancy. ( 27042562 )
2016

Variations for Wolff-Parkinson-White Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

76
# Symbol AA change Variation ID SNP ID
1 PRKAG2 p.Arg302Gln VAR_013264 rs121908987
2 PRKAG2 p.Arg531Gly VAR_032909 rs121908990

ClinVar genetic disease variations for Wolff-Parkinson-White Syndrome:

6 (show top 50) (show all 310)
# Gene Variation Type Significance SNP ID Assembly Location
1 PRKAG2 NM_016203.3(PRKAG2): c.202G> A (p.Gly68Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs730880970 GRCh38 Chromosome 7, 151781416: 151781416
2 PRKAG2 NM_016203.3(PRKAG2): c.202G> A (p.Gly68Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs730880970 GRCh37 Chromosome 7, 151478502: 151478502
3 CACNA1C NM_000719.6(CACNA1C): c.1485C> A (p.His495Gln) single nucleotide variant Uncertain significance rs373335068 GRCh37 Chromosome 12, 2666120: 2666120
4 CACNA1C NM_000719.6(CACNA1C): c.1485C> A (p.His495Gln) single nucleotide variant Uncertain significance rs373335068 GRCh38 Chromosome 12, 2556954: 2556954
5 CACNA1C NM_001129842.1(CACNA1C): c.2579G> A (p.Arg860Gln) single nucleotide variant Uncertain significance rs730880056 GRCh37 Chromosome 12, 2702427: 2702427
6 CACNA1C NM_001129842.1(CACNA1C): c.2579G> A (p.Arg860Gln) single nucleotide variant Uncertain significance rs730880056 GRCh38 Chromosome 12, 2593261: 2593261
7 SNTA1 NM_003098.2(SNTA1): c.1088A> C (p.Glu363Ala) single nucleotide variant Uncertain significance rs147964932 GRCh37 Chromosome 20, 31998090: 31998090
8 SNTA1 NM_003098.2(SNTA1): c.1088A> C (p.Glu363Ala) single nucleotide variant Uncertain significance rs147964932 GRCh38 Chromosome 20, 33410284: 33410284
9 LAMA4 NM_002290.4(LAMA4): c.2377C> T (p.Arg793Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs202184174 GRCh37 Chromosome 6, 112466091: 112466091
10 LAMA4 NM_002290.4(LAMA4): c.2377C> T (p.Arg793Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs202184174 GRCh38 Chromosome 6, 112144889: 112144889
11 RYR2 NM_001035.2(RYR2): c.11919T> G (p.Asp3973Glu) single nucleotide variant Uncertain significance rs370103782 GRCh37 Chromosome 1, 237944903: 237944903
12 RYR2 NM_001035.2(RYR2): c.11919T> G (p.Asp3973Glu) single nucleotide variant Uncertain significance rs370103782 GRCh38 Chromosome 1, 237781603: 237781603
13 SCN5A NM_198056.2(SCN5A): c.1705C> G (p.Arg569Gly) single nucleotide variant Uncertain significance rs199473576 GRCh37 Chromosome 3, 38645388: 38645388
14 SCN5A NM_198056.2(SCN5A): c.1705C> G (p.Arg569Gly) single nucleotide variant Uncertain significance rs199473576 GRCh38 Chromosome 3, 38603897: 38603897
15 JUP NM_021991.3(JUP): c.773A> G (p.Glu258Gly) single nucleotide variant Uncertain significance rs794729052 GRCh37 Chromosome 17, 39923767: 39923767
16 JUP NM_021991.3(JUP): c.773A> G (p.Glu258Gly) single nucleotide variant Uncertain significance rs794729052 GRCh38 Chromosome 17, 41767515: 41767515
17 SLC26A4 NM_000441.1(SLC26A4): c.85G> C (p.Glu29Gln) single nucleotide variant Pathogenic/Likely pathogenic rs111033205 GRCh37 Chromosome 7, 107302171: 107302171
18 SLC26A4 NM_000441.1(SLC26A4): c.85G> C (p.Glu29Gln) single nucleotide variant Pathogenic/Likely pathogenic rs111033205 GRCh38 Chromosome 7, 107661726: 107661726
19 PRKAG2 NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln) single nucleotide variant Pathogenic rs121908987 GRCh37 Chromosome 7, 151273498: 151273498
20 PRKAG2 NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln) single nucleotide variant Pathogenic rs121908987 GRCh38 Chromosome 7, 151576412: 151576412
21 NODAL NM_018055.4(NODAL): c.778G> A (p.Gly260Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs121909283 GRCh37 Chromosome 10, 72195155: 72195155
22 NODAL NM_018055.4(NODAL): c.778G> A (p.Gly260Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs121909283 GRCh38 Chromosome 10, 70435399: 70435399
23 MYH7 NM_000257.3(MYH7): c.728G> A (p.Arg243His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606910 GRCh37 Chromosome 14, 23900798: 23900798
24 MYH7 NM_000257.3(MYH7): c.728G> A (p.Arg243His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606910 GRCh38 Chromosome 14, 23431589: 23431589
25 MYH6 NM_002471.3(MYH6): c.3010G> T (p.Ala1004Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs143978652 GRCh37 Chromosome 14, 23862646: 23862646
26 MYH6 NM_002471.3(MYH6): c.3010G> T (p.Ala1004Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs143978652 GRCh38 Chromosome 14, 23393437: 23393437
27 MYBPC3 NM_000256.3(MYBPC3): c.1321G> A (p.Glu441Lys) single nucleotide variant Uncertain significance rs193922377 GRCh37 Chromosome 11, 47364602: 47364602
28 MYBPC3 NM_000256.3(MYBPC3): c.1321G> A (p.Glu441Lys) single nucleotide variant Uncertain significance rs193922377 GRCh38 Chromosome 11, 47343051: 47343051
29 PRKAG2 NM_016203.3(PRKAG2): c.1593G> A (p.Arg531=) single nucleotide variant Conflicting interpretations of pathogenicity rs148197254 GRCh37 Chromosome 7, 151257695: 151257695
30 PRKAG2 NM_016203.3(PRKAG2): c.1593G> A (p.Arg531=) single nucleotide variant Conflicting interpretations of pathogenicity rs148197254 GRCh38 Chromosome 7, 151560609: 151560609
31 PRKAG2 NM_016203.3(PRKAG2): c.298G> A (p.Gly100Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs79474211 GRCh37 Chromosome 7, 151478406: 151478406
32 PRKAG2 NM_016203.3(PRKAG2): c.298G> A (p.Gly100Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs79474211 GRCh38 Chromosome 7, 151781320: 151781320
33 MYH7 NM_000257.3(MYH7): c.2389G> A (p.Ala797Thr) single nucleotide variant Pathogenic/Likely pathogenic rs3218716 GRCh37 Chromosome 14, 23894525: 23894525
34 MYH7 NM_000257.3(MYH7): c.2389G> A (p.Ala797Thr) single nucleotide variant Pathogenic/Likely pathogenic rs3218716 GRCh38 Chromosome 14, 23425316: 23425316
35 MYH7 NM_000257.4(MYH7): c.4377G> T (p.Lys1459Asn) single nucleotide variant Likely benign rs201307101 GRCh37 Chromosome 14, 23886504: 23886504
36 MYH7 NM_000257.4(MYH7): c.4377G> T (p.Lys1459Asn) single nucleotide variant Likely benign rs201307101 GRCh38 Chromosome 14, 23417295: 23417295
37 RYR2 NM_001035.2(RYR2): c.8162T> C (p.Ile2721Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs201500134 GRCh37 Chromosome 1, 237821276: 237821276
38 RYR2 NM_001035.2(RYR2): c.8162T> C (p.Ile2721Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs201500134 GRCh38 Chromosome 1, 237657976: 237657976
39 PRKAG2 NM_016203.3(PRKAG2): c.*3G> A single nucleotide variant Benign/Likely benign rs113234987 GRCh37 Chromosome 7, 151254284: 151254284
40 PRKAG2 NM_016203.3(PRKAG2): c.*3G> A single nucleotide variant Benign/Likely benign rs113234987 GRCh38 Chromosome 7, 151557198: 151557198
41 PRKAG2 NM_016203.3(PRKAG2): c.111T> A (p.Ile37=) single nucleotide variant Conflicting interpretations of pathogenicity rs144426409 GRCh37 Chromosome 7, 151573595: 151573595
42 PRKAG2 NM_016203.3(PRKAG2): c.111T> A (p.Ile37=) single nucleotide variant Conflicting interpretations of pathogenicity rs144426409 GRCh38 Chromosome 7, 151876510: 151876510
43 PRKAG2 NM_016203.3(PRKAG2): c.114+12C> T single nucleotide variant Benign/Likely benign rs77902041 GRCh37 Chromosome 7, 151573580: 151573580
44 PRKAG2 NM_016203.3(PRKAG2): c.114+12C> T single nucleotide variant Benign/Likely benign rs77902041 GRCh38 Chromosome 7, 151876495: 151876495
45 PRKAG2 NM_016203.3(PRKAG2): c.123C> T (p.Ser41=) single nucleotide variant Conflicting interpretations of pathogenicity rs397517263 GRCh37 Chromosome 7, 151483619: 151483619
46 PRKAG2 NM_016203.3(PRKAG2): c.123C> T (p.Ser41=) single nucleotide variant Conflicting interpretations of pathogenicity rs397517263 GRCh38 Chromosome 7, 151786533: 151786533
47 PRKAG2 NM_016203.3(PRKAG2): c.1390G> A (p.Asp464Asn) single nucleotide variant Uncertain significance rs397517264 GRCh37 Chromosome 7, 151262815: 151262815
48 PRKAG2 NM_016203.3(PRKAG2): c.1390G> A (p.Asp464Asn) single nucleotide variant Uncertain significance rs397517264 GRCh38 Chromosome 7, 151565729: 151565729
49 PRKAG2 NM_016203.3(PRKAG2): c.1623T> C (p.Ile541=) single nucleotide variant Benign/Likely benign rs28763998 GRCh37 Chromosome 7, 151257665: 151257665
50 PRKAG2 NM_016203.3(PRKAG2): c.1623T> C (p.Ile541=) single nucleotide variant Benign/Likely benign rs28763998 GRCh38 Chromosome 7, 151560579: 151560579

Expression for Wolff-Parkinson-White Syndrome

Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for Wolff-Parkinson-White Syndrome

Pathways related to Wolff-Parkinson-White Syndrome according to KEGG:

38
# Name Kegg Source Accession
1 Insulin signaling pathway hsa04910
2 Adipocytokine signaling pathway hsa04920
3 Hypertrophic cardiomyopathy (HCM) hsa05410

Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 MYH7 NPPB PRKAA1 PRKAA2 PRKAG2 PRKAG3
2
Show member pathways
12.42 PRKAA1 PRKAA2 PRKAG2 PRKAG3
3 12.42 CBS PRKAA1 PRKAA2 PRKAG2 PRKAG3
4
Show member pathways
12.37 BMP2 MYH7 NKX2-5 NPPB
5
Show member pathways
12.34 PRKAA1 PRKAA2 PRKAG2 PRKAG3
6
Show member pathways
12.32 PRKAA1 PRKAA2 PRKAG2 PRKAG3
7
Show member pathways
12.13 PRKAA1 PRKAA2 PRKAG2 PRKAG3
8 12.12 PRKAA1 PRKAA2 PRKAG2 PRKAG3
9
Show member pathways
12.08 PRKAA1 PRKAA2 PRKAG2 PRKAG3
10
Show member pathways
12.05 PRKAA1 PRKAA2 PRKAG2 PRKAG3
11
Show member pathways
12.03 PRKAA1 PRKAA2 PRKAG2 PRKAG3
12
Show member pathways
11.99 PRKAA1 PRKAA2 PRKAG2 PRKAG3
13
Show member pathways
11.87 PRKAA1 PRKAA2 PRKAG2 PRKAG3
14 11.86 JAG1 PRKAA1 PRKAA2 PRKAG2 PRKAG3
15 11.82 PRKAA1 PRKAA2 PRKAG2 PRKAG3
16 11.71 PRKAA1 PRKAA2 PRKAG2 PRKAG3
17
Show member pathways
11.68 MYH7 PRKAA1 PRKAA2 PRKAG2 PRKAG3 TNNI3
18 11.62 PRKAA1 PRKAA2 PRKAG2 PRKAG3
19 11.57 PRKAA1 PRKAA2 PRKAG2 PRKAG3
20 11.51 NKX2-5 TBX20 TNNI3
21 11.5 MYH7 PRKAA2 PRKAG2 PRKAG3
22 11.42 BMP2 NKX2-5 TBX20
23 11.39 PRKAA1 PRKAA2 PRKAG2 PRKAG3
24
Show member pathways
11.19 PRKAA1 PRKAA2 PRKAG2 PRKAG3
25 11.01 PRKAA1 PRKAA2 PRKAG2 PRKAG3
26 10.65 PRKAA2 PRKAG2
27 10.27 BMP2 MYH7 NKX2-5 NPPB

GO Terms for Wolff-Parkinson-White Syndrome

Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin complex GO:0005861 8.96 TNNI3 TNNT1
2 nucleotide-activated protein kinase complex GO:0031588 8.92 PRKAA1 PRKAA2 PRKAG2 PRKAG3

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 fatty acid metabolic process GO:0006631 9.83 PRKAA1 PRKAA2 PRKAG2 PRKAG3
2 cell cycle arrest GO:0007050 9.8 PRKAA1 PRKAA2 PRKAG2 PRKAG3
3 inner ear development GO:0048839 9.73 BMP2 JAG1 KCNQ1
4 muscle contraction GO:0006936 9.73 MYH7 TBX20 TNNI3 TNNT1
5 aortic valve morphogenesis GO:0003180 9.67 JAG1 TBX20
6 embryonic heart tube development GO:0035050 9.66 NKX2-5 TBX20
7 lipid biosynthetic process GO:0008610 9.65 PRKAA1 PRKAA2
8 positive regulation of glycolytic process GO:0045821 9.65 PRKAA1 PRKAA2
9 regulation of muscle contraction GO:0006937 9.65 TNNI3 TNNT1
10 muscle filament sliding GO:0030049 9.65 MYH7 TNNI3 TNNT1
11 cardiovascular system development GO:0072358 9.64 KCNQ1 NKX2-5
12 cellular response to prostaglandin E stimulus GO:0071380 9.64 PRKAA1 PRKAA2
13 endocardial cushion morphogenesis GO:0003203 9.63 BMP2 TBX20
14 fatty acid homeostasis GO:0055089 9.63 PRKAA1 PRKAA2
15 sterol biosynthetic process GO:0016126 9.63 PRKAA1 PRKAA2 PRKAG2
16 striated muscle contraction GO:0006941 9.62 MYH7 TNNI3
17 adult heart development GO:0007512 9.62 MYH7 NKX2-5
18 heart contraction GO:0060047 9.61 NKX2-5 TNNI3
19 cardiac right ventricle morphogenesis GO:0003215 9.61 JAG1 TBX20
20 atrial septum morphogenesis GO:0060413 9.6 NKX2-5 TBX20
21 cellular response to nutrient levels GO:0031669 9.59 PRKAA1 PRKAA2
22 transition between fast and slow fiber GO:0014883 9.58 MYH7 TNNT1
23 regulation of fatty acid biosynthetic process GO:0042304 9.58 PRKAA2 PRKAG2
24 positive regulation of cellular protein localization GO:1903829 9.57 PRKAA1 PRKAA2
25 macroautophagy GO:0016236 9.56 PRKAA1 PRKAA2 PRKAG2 PRKAG3
26 negative regulation of tubulin deacetylation GO:1904428 9.55 PRKAA1 PRKAA2
27 regulation of protein serine/threonine kinase activity GO:0071900 9.54 PRKAG2 PRKAG3
28 histone-serine phosphorylation GO:0035404 9.51 PRKAA1 PRKAA2
29 skeletal muscle contraction GO:0003009 9.5 MYH7 TNNI3 TNNT1
30 positive regulation of peptidyl-lysine acetylation GO:2000758 9.4 PRKAA1 PRKAA2
31 regulation of stress granule assembly GO:0062028 9.37 PRKAA1 PRKAA2
32 cardiac muscle tissue morphogenesis GO:0055008 9.33 BMP2 NKX2-5 TBX20
33 fatty acid biosynthetic process GO:0006633 9.26 PRKAA1 PRKAA2 PRKAG2 PRKAG3
34 cardiac muscle contraction GO:0060048 9.02 KCNQ1 MYH7 NKX2-5 TNNI3 TNNT1
35 protein phosphorylation GO:0006468 10.06 BMP2 PRKAA1 PRKAA2 PRKAG2 PRKAG3

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone serine kinase activity GO:0035174 9.37 PRKAA1 PRKAA2
2 adenyl ribonucleotide binding GO:0032559 9.32 PRKAG2 PRKAG3
3 troponin T binding GO:0031014 9.26 TNNI3 TNNT1
4 [acetyl-CoA carboxylase] kinase activity GO:0050405 9.16 PRKAA1 PRKAA2
5 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity GO:0047322 8.96 PRKAA1 PRKAA2
6 AMP-activated protein kinase activity GO:0004679 8.92 PRKAA1 PRKAA2 PRKAG2 PRKAG3

Sources for Wolff-Parkinson-White Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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