WPWS
MCID: WLF001
MIFTS: 61

Wolff-Parkinson-White Syndrome (WPWS)

Categories: Cardiovascular diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

MalaCards integrated aliases for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 58 12 77 54 26 76 13 56 6 45 15 17 74
Wolff-Parkinson-White Pattern 12 30 6 41
Wpw Syndrome 58 54 26
Ventricular Familial Preexcitation Syndrome 54 76
Anomalous Atrioventricular Excitation 12 74
Preexcitation Syndrome 54 74
Auriculoventricular Accessory Pathway Syndrome 54
Ventricular Pre-Excitation with Arrhythmia 26
Anomalous Ventricular Excitation Syndrome 54
False Bundle Branch Block Syndrome 54
Wolff-Parkinson-White Syndrome 38
Ventricular Preexcitation 74
Anomalous a-V Excitation 12
Wpws 76

Characteristics:

OMIM:

58
Inheritance:
? autosomal dominant factor


HPO:

33
wolff-parkinson-white syndrome:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Wolff-Parkinson-White Syndrome

NIH Rare Diseases : 54 Wolff-Parkinson-White syndrome causes a problem with the rate or rhythm of the heartbeat (arrhythmia). People with the syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart. This leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. The most common arrhythmia associated with Wolff-Parkinson-White syndrome is paroxysmal supraventricular tachycardia. The syndrome is especially common in people of Chinese descent. In most cases, the cause of Wolff-Parkinson-White syndrome is unknown. A small percentage of cases are caused by genetic changes (mutations or pathogenic variants) in the PRKAG2 gene. These cases appear to be inherited in an autosomal dominant manner. A diagnosis of the syndrome is based on an electrocardiogram (ECG) or Holter test that shows episodes of tachycardia. Treatment for the syndrome may depend on the severity of symptoms but can include medications or surgery.

MalaCards based summary : Wolff-Parkinson-White Syndrome, also known as wolff-parkinson-white pattern, is related to cardiomyopathy, familial hypertrophic, 6 and atrial standstill 1. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways/superpathways are Insulin signaling pathway and Adipocytokine signaling pathway. The drugs Adenosine and Amiodarone have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and atrioventricular node, and related phenotypes are sudden cardiac death and cardiomyopathy

Genetics Home Reference : 26 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

UniProtKB/Swiss-Prot : 76 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Wikipedia : 77 Wolff–Parkinson–White syndrome (WPWS) is a disorder due to a specific type of problem with the... more...

Description from OMIM: 194200

Related Diseases for Wolff-Parkinson-White Syndrome

Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 cardiomyopathy, familial hypertrophic, 6 33.6 PRKAG2 TNNI3
2 atrial standstill 1 31.3 MYH7 NPPB PRKAG2 TNNI3
3 hypertrophic cardiomyopathy 31.2 MYH7 PRKAG2 TNNI3 TNNT1
4 cardiomyopathy, familial hypertrophic, 1 30.8 MYH7 TNNI3 TNNT1
5 atrioventricular block 30.8 KCNQ1 NKX2-5 NPPB
6 cardiac arrest 30.6 KCNQ1 MYH7 NPPB
7 third-degree atrioventricular block 30.4 NPPB PRKAG2
8 ventricular septal defect 30.3 JAG1 MYH7 NKX2-5 NPPB
9 dilated cardiomyopathy 30.0 KCNQ1 MYH7 NKX2-5 NPPB PRKAG2 TBX20
10 heart disease 30.0 CBS JAG1 KCNQ1 MYH7 NKX2-5 NPPB
11 cardiomyopathy, infantile histiocytoid 11.5
12 20p12.3 microdeletion syndrome 11.5
13 atrial fibrillation 11.2
14 myoclonic epilepsy associated with ragged-red fibers 11.2
15 myocardial infarction 11.0
16 ventricular fibrillation, paroxysmal familial, 1 10.9
17 progressive familial heart block, type ia 10.8
18 syncope 10.7
19 mitral valve stenosis 10.6
20 cardiac conduction defect 10.6
21 progressive familial heart block, type ib 10.6
22 acute myocardial infarction 10.6
23 brugada syndrome 10.6
24 right bundle branch block 10.6
25 tuberous sclerosis 10.6
26 depression 10.5
27 graves disease 1 10.5
28 orthostatic intolerance 10.5
29 left bundle branch hemiblock 10.5
30 myocarditis 10.5
31 muscular dystrophy 10.5
32 endocarditis 10.4
33 epilepsy 10.4
34 aortic coarctation 10.4
35 double discordia 10.4
36 glycogen storage disease of heart, lethal congenital 10.4 PRKAG2 PRKAG2-AS1
37 rheumatic fever-related antigen 10.3
38 muscular dystrophy, duchenne type 10.3
39 asthma 10.3
40 tricuspid atresia 10.3
41 congestive heart failure 10.3
42 rheumatic fever 10.3
43 atrial heart septal defect 10.3
44 optic nerve disease 10.3
45 ischemia 10.3
46 lactic acidosis 10.3
47 hyperthyroidism 10.3
48 neuropathy 10.3
49 dextrocardia 10.3
50 rere-related disorders 10.3

Comorbidity relations with Wolff-Parkinson-White Syndrome via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to Wolff-Parkinson-White Syndrome

Symptoms & Phenotypes for Wolff-Parkinson-White Syndrome

Human phenotypes related to Wolff-Parkinson-White Syndrome:

33 (show all 10)
# Description HPO Frequency HPO Source Accession
1 sudden cardiac death 33 HP:0001645
2 cardiomyopathy 33 HP:0001638
3 wolff-parkinson-white syndrome 33 HP:0001716
4 stroke 33 HP:0001297
5 palpitations 33 HP:0001962
6 shortened pr interval 33 HP:0005165
7 prolonged qrs complex 33 HP:0006677
8 paroxysmal supraventricular tachycardia 33 HP:0004763
9 paroxysmal atrial fibrillation 33 HP:0004757
10 ventricular preexcitation with multiple accessory pathways 33 HP:0006684

Symptoms via clinical synopsis from OMIM:

58
Cardiac:
palpitations
short pr interval and prolonged qrs, with slurred-up stroke of the r wave (delta wave) on ekg
paroxysmal supraventricular tachycardia
paroxysmal atrial fibrillation
familial cardiomyopathy
more

Clinical features from OMIM:

194200

MGI Mouse Phenotypes related to Wolff-Parkinson-White Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 BMP2 COL5A1 DNAAF3 JAG1 KCNQ1 MYH7
2 hearing/vestibular/ear MP:0005377 9.43 BMP2 GJC3 JAG1 KCNQ1 PRKAA2 SLC26A4
3 muscle MP:0005369 9.32 JAG1 KCNQ1 MYH7 NKX2-5 PRKAA1 PRKAA2

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

Drugs for Wolff-Parkinson-White Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adenosine Approved, Investigational 58-61-7 60961
2
Amiodarone Approved, Investigational 1951-25-3 2157
3
Digoxin Approved 20830-75-5 2724385 30322
4
Propranolol Approved, Investigational 525-66-6 4946
5
Procainamide Approved 51-06-9 4913
6 Neurotransmitter Agents
7 Cytochrome P-450 CYP3A Inhibitors
8 Sodium Channel Blockers
9 Cytochrome P-450 Enzyme Inhibitors
10 Adrenergic Agents
11 Cardiotonic Agents
12 Potassium Channel Blockers
13 Adrenergic Antagonists
14 Peripheral Nervous System Agents
15 Anti-Arrhythmia Agents
16 Analgesics
17 Protective Agents
18 Cytochrome P-450 CYP2C9 Inhibitors
19 Cytochrome P-450 CYP1A2 Inhibitors
20 Antihypertensive Agents
21 Diuretics, Potassium Sparing
22 Adrenergic beta-Antagonists
23 Cytochrome P-450 CYP2D6 Inhibitors
24 Vasodilator Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Safety, Tolerability and Efficacy of BAF312 Given Orally in Patients With Relapsing-remitting Multiple Sclerosis Completed NCT01185821 Phase 2 BAF312
2 Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECG Completed NCT00251121 Not Applicable
3 Risk Assessment in Patients With Symptomatic- and Asymptomatic Preexcitation Recruiting NCT03301935
4 Stress ECG Test for the Evaluation of the Risk of Sudden Cardiac Death in a Paediatric Cohort With WPW Pattern Enrolling by invitation NCT03207373 Not Applicable
5 Management of Supraventricular Tachycardia of Children Not yet recruiting NCT03528616 adenosine,Propranolol,flecainide, amiodarone, propranolol, digoxin and procainamide.
6 Left Atrial Appendage Closure in Combination With Catheter Ablation Not yet recruiting NCT03788941
7 Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory Duct Terminated NCT00873470 Not Applicable

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

Genetic tests related to Wolff-Parkinson-White Syndrome:

# Genetic test Affiliating Genes
1 Wolff-Parkinson-White Pattern 30 PRKAG2

Anatomical Context for Wolff-Parkinson-White Syndrome

MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

42
Testes, Heart, Atrioventricular Node, Spinal Cord, Thyroid, Brain, Kidney

Publications for Wolff-Parkinson-White Syndrome

Articles related to Wolff-Parkinson-White Syndrome:

(show top 50) (show all 1560)
# Title Authors Year
1
Syncope in a Patient With Wolff-Parkinson-White Pattern: Not All That Glitters Is Gold. ( 30715074 )
2019
2
Accessory pathway-related left ventricular wall motion abnormality and the effects of radiofrequency catheter ablation in patients with Wolff-Parkinson-White syndrome. ( 30255617 )
2019
3
Antipsychotics for patients with Wolff-Parkinson-White Syndrome. ( 30649911 )
2019
4
Localization of Accessory Pathways in Pediatric Patients With Wolff-Parkinson-White Syndrome Using 3D-Rendered Electromechanical Wave Imaging. ( 31000096 )
2019
5
Revelation of early repolarization by eliminating accessory pathway in manifest Wolff-Parkinson-White syndrome: A case report. ( 31007798 )
2019
6
Localization Of Accessory Pathways In Wolff Parkinson White Syndrome Using R/S Ratios On Surface Ecgs. ( 31094105 )
2019
7
Management of Asymptomatic Wolff-Parkinson-White Pattern in Young Patients: Has Anything Changed? ( 31069431 )
2019
8
Acute myocardial infarction in a patient with Wolff-Parkinson-White syndrome. ( 30344545 )
2018
9
Prognostic Significance and Risk of Atrial Fibrillation of Wolff-Parkinson-White Syndrome in Patients With Hypertrophic Cardiomyopathy. ( 30201118 )
2018
10
Late restored cardiac function after successful resynchronization by right posterior accessory pathway ablation in Wolff-Parkinson-White syndrome associated dilated cardiomyopathy. ( 29452709 )
2018
11
Wolff-Parkinson-White Syndrome in a Patient with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Syndrome Mimicking Juvenile Myoclonic Epilepsy. ( 29629547 )
2018
12
Wolff-Parkinson White syndrome in a parturient with rheumatic heart disease for caesarean section - Anaesthesia management. ( 30166666 )
2018
13
Aborted sudden cardiac death in a young soldier with concomitant hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome. ( 30585570 )
2018
14
Masking of myocardial infarction ECG in a patient with Wolff-Parkinson-White syndrome. ( 30386861 )
2018
15
Wolff-Parkinson-White syndrome and noncompaction in Leber's hereditary optic neuropathy due to the variant m.3460G>A. ( 29562793 )
2018
16
Wolff-Parkinson-White syndrome presenting with steroid-induced bradycardia in a patient with acute rheumatic fever. ( 30070198 )
2018
17
Radiofrequency ablation of accessory pathways in patients with the Wolff-Parkinson-White syndrome: long-term risk of mortality and coronary events. ( 28605443 )
2018
18
Characterisation of three-dimensional mapping in Wolff-Parkinson-White syndrome with septal aneurysmal dyskinesis. ( 28847328 )
2018
19
Supraventricular tachycardia in a trauma patient masquerading as a Wolff-Parkinson-White syndrome. ( 28927735 )
2018
20
MY APPROACH to the Athlete With Wolff-Parkinson-White Syndrome (WPW). ( 29032933 )
2018
21
Electrophysiological effects of desflurane in children with Wolff-Parkinson-White syndrome: a randomized crossover study. ( 29068040 )
2018
22
A case of Wolff-Parkinson-White syndrome presenting spontaneous mutual frequent transition between atrioventricular reciprocating tachycardia and atrioventricular nodal re-entrant tachycardia. ( 29478804 )
2018
23
Molecular Pathogenesis of Familial Wolff-Parkinson-White Syndrome. ( 29593177 )
2018
24
Complications of Radiofrequency Ablation for Supraventricular Tachycardia in the Wolff-Parkinson-White Syndrome Associated With Noncompaction Cardiomyopathy. ( 29706203 )
2018
25
Epicardial Intraoperative Three-Dimensional Mapping of Wolff-Parkinson-White Syndrome in a Child With Ebstein's Anomaly. ( 29730348 )
2018
26
Isolated Wolff-Parkinson-White syndrome in identical twins. ( 29755940 )
2018
27
Pharmacologic therapy with flecainide for asymptomatic Wolff-Parkinson-White syndrome in an infant with severe left ventricular dyssynchrony. ( 29848398 )
2018
28
Altered myocardial characteristics of the preexcited segment in Wolff-Parkinson-White syndrome: A pilot study with cardiac magnetic resonance imaging. ( 29856866 )
2018
29
Delta wave notching time is associated with accessory pathway localization in patients with Wolff-Parkinson-White syndrome. ( 30014371 )
2018
30
Antidromic Atrioventricular Reentry Tachycardia with Wolff Parkinson White Syndrome: A Rare Beast. ( 30034964 )
2018
31
Life-Threatening Event Risk in Children With Wolff-Parkinson-White Syndrome: A Multicenter International Study. ( 30067481 )
2018
32
Fast, Broad, and Irregular: Wolff-Parkinson-White Syndrome. ( 30102907 )
2018
33
Three-dimensional histologic reconstruction of remnant functional accessory atrioventricular myocardial connections in a case of Wolff-Parkinson-White syndrome. ( 30121003 )
2018
34
The coexistence of Wolff-Parkinson-White syndrome (WPW) and atrioventricular nodal reentrant tachycardia (AVNRT). ( 30191196 )
2018
35
Wolff-Parkinson-White syndrome due to a left atrial appendage-to-left ventricular connection: A case of a successful pathway elimination from inside of the left atrial appendage. ( 30479950 )
2018
36
Rheumatic Mitral Stenosis with Incidental Wolff-Parkinson-White Syndrome: A Rare Association. Treated by Percutaneous Transmitral Commissurotomy and Radiofrequency Ablation. ( 30505396 )
2018
37
Sudden cardiac death due to the Wolff-Parkinson-White syndrome: A case report with genetic analysis. ( 30572429 )
2018
38
Spontaneous regression of submitral pseudoaneurysm after radiofrequency catheter ablation in a patient with Wolff-Parkinson-White syndrome. ( 30581737 )
2018
39
Wolff-Parkinson-White pattern unmasked by severe musculoskeletal pain. ( 30004382 )
2018
40
Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome. ( 28491758 )
2017
41
Reversal of Wolff-Parkinson-White Syndrome induced dilated cardiomyopathy via resynchronization and subsequent accessory pathway ablation. ( 29238369 )
2017
42
Accessory pathway location affects brain natriuretic peptide level in patients with Wolff-Parkinson-White syndrome. ( 27815796 )
2017
43
Wolff-Parkinson-White syndrome: a single exercise stress test might be misleading. ( 27869041 )
2017
44
Wolff-Parkinson-White syndrome: lessons learnt and lessons remaining. ( 28084962 )
2017
45
Wolff-Parkinson-White Syndrome Associated With a Fistula Between the Right Atrial Appendage and Right Ventricle. ( 28214246 )
2017
46
Successful ablation of a right atrium-axillary ventricular accessory pathway associated with Wolff-Parkinson-White syndrome. ( 28543607 )
2017
47
Wolff-Parkinson-White Syndrome with Ventricular Hypertrophy in a Brazilian Family. ( 28690312 )
2017
48
The impact of left ventricular deformation and dyssynchrony on improvement of left ventricular ejection fraction following radiofrequency catheter ablation in Wolff-Parkinson-White syndrome: A comprehensive study by speckle tracking echocardiography. ( 28929532 )
2017
49
A Case of Multiple Cardiovascular and Tracheal Anomalies Presented with Wolff-Parkinson-White Syndrome in a Middle-aged Adult. ( 29115093 )
2017
50
A case of Type-C Wolff-Parkinson-White syndrome with severe left ventricular dysfunction: Efficacy of catheter ablation. ( 30524579 )
2017

Variations for Wolff-Parkinson-White Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

76
# Symbol AA change Variation ID SNP ID
1 PRKAG2 p.Arg302Gln VAR_013264 rs121908987
2 PRKAG2 p.Arg531Gly VAR_032909 rs121908990

ClinVar genetic disease variations for Wolff-Parkinson-White Syndrome:

6 (show top 50) (show all 312)
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC26A4 NM_000441.1(SLC26A4): c.85G> C (p.Glu29Gln) single nucleotide variant Pathogenic/Likely pathogenic rs111033205 GRCh37 Chromosome 7, 107302171: 107302171
2 SLC26A4 NM_000441.1(SLC26A4): c.85G> C (p.Glu29Gln) single nucleotide variant Pathogenic/Likely pathogenic rs111033205 GRCh38 Chromosome 7, 107661726: 107661726
3 PRKAG2 NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln) single nucleotide variant Pathogenic rs121908987 GRCh37 Chromosome 7, 151273498: 151273498
4 PRKAG2 NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln) single nucleotide variant Pathogenic rs121908987 GRCh38 Chromosome 7, 151576412: 151576412
5 NODAL NM_018055.4(NODAL): c.778G> A (p.Gly260Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs121909283 GRCh37 Chromosome 10, 72195155: 72195155
6 NODAL NM_018055.4(NODAL): c.778G> A (p.Gly260Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs121909283 GRCh38 Chromosome 10, 70435399: 70435399
7 MYH7 NM_000257.3(MYH7): c.728G> A (p.Arg243His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606910 GRCh37 Chromosome 14, 23900798: 23900798
8 MYH7 NM_000257.3(MYH7): c.728G> A (p.Arg243His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606910 GRCh38 Chromosome 14, 23431589: 23431589
9 MYH6 NM_002471.3(MYH6): c.3010G> T (p.Ala1004Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs143978652 GRCh37 Chromosome 14, 23862646: 23862646
10 MYH6 NM_002471.3(MYH6): c.3010G> T (p.Ala1004Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs143978652 GRCh38 Chromosome 14, 23393437: 23393437
11 MYBPC3 NM_000256.3(MYBPC3): c.1321G> A (p.Glu441Lys) single nucleotide variant Uncertain significance rs193922377 GRCh37 Chromosome 11, 47364602: 47364602
12 MYBPC3 NM_000256.3(MYBPC3): c.1321G> A (p.Glu441Lys) single nucleotide variant Uncertain significance rs193922377 GRCh38 Chromosome 11, 47343051: 47343051
13 PRKAG2 NM_016203.3(PRKAG2): c.1593G> A (p.Arg531=) single nucleotide variant Conflicting interpretations of pathogenicity rs148197254 GRCh37 Chromosome 7, 151257695: 151257695
14 PRKAG2 NM_016203.3(PRKAG2): c.1593G> A (p.Arg531=) single nucleotide variant Conflicting interpretations of pathogenicity rs148197254 GRCh38 Chromosome 7, 151560609: 151560609
15 PRKAG2 NM_016203.3(PRKAG2): c.298G> A (p.Gly100Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs79474211 GRCh37 Chromosome 7, 151478406: 151478406
16 PRKAG2 NM_016203.3(PRKAG2): c.298G> A (p.Gly100Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs79474211 GRCh38 Chromosome 7, 151781320: 151781320
17 MYH7 NM_000257.3(MYH7): c.2389G> A (p.Ala797Thr) single nucleotide variant Pathogenic/Likely pathogenic rs3218716 GRCh37 Chromosome 14, 23894525: 23894525
18 MYH7 NM_000257.3(MYH7): c.2389G> A (p.Ala797Thr) single nucleotide variant Pathogenic/Likely pathogenic rs3218716 GRCh38 Chromosome 14, 23425316: 23425316
19 MYH7 NM_000257.4(MYH7): c.4377G> T (p.Lys1459Asn) single nucleotide variant Likely benign rs201307101 GRCh37 Chromosome 14, 23886504: 23886504
20 MYH7 NM_000257.4(MYH7): c.4377G> T (p.Lys1459Asn) single nucleotide variant Likely benign rs201307101 GRCh38 Chromosome 14, 23417295: 23417295
21 RYR2 NM_001035.2(RYR2): c.8162T> C (p.Ile2721Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs201500134 GRCh37 Chromosome 1, 237821276: 237821276
22 RYR2 NM_001035.2(RYR2): c.8162T> C (p.Ile2721Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs201500134 GRCh38 Chromosome 1, 237657976: 237657976
23 PRKAG2 NM_016203.3(PRKAG2): c.*3G> A single nucleotide variant Benign/Likely benign rs113234987 GRCh37 Chromosome 7, 151254284: 151254284
24 PRKAG2 NM_016203.3(PRKAG2): c.*3G> A single nucleotide variant Benign/Likely benign rs113234987 GRCh38 Chromosome 7, 151557198: 151557198
25 PRKAG2 NM_016203.3(PRKAG2): c.111T> A (p.Ile37=) single nucleotide variant Conflicting interpretations of pathogenicity rs144426409 GRCh37 Chromosome 7, 151573595: 151573595
26 PRKAG2 NM_016203.3(PRKAG2): c.111T> A (p.Ile37=) single nucleotide variant Conflicting interpretations of pathogenicity rs144426409 GRCh38 Chromosome 7, 151876510: 151876510
27 PRKAG2 NM_016203.3(PRKAG2): c.114+12C> T single nucleotide variant Benign/Likely benign rs77902041 GRCh37 Chromosome 7, 151573580: 151573580
28 PRKAG2 NM_016203.3(PRKAG2): c.114+12C> T single nucleotide variant Benign/Likely benign rs77902041 GRCh38 Chromosome 7, 151876495: 151876495
29 PRKAG2 NM_016203.3(PRKAG2): c.123C> T (p.Ser41=) single nucleotide variant Conflicting interpretations of pathogenicity rs397517263 GRCh37 Chromosome 7, 151483619: 151483619
30 PRKAG2 NM_016203.3(PRKAG2): c.123C> T (p.Ser41=) single nucleotide variant Conflicting interpretations of pathogenicity rs397517263 GRCh38 Chromosome 7, 151786533: 151786533
31 PRKAG2 NM_016203.3(PRKAG2): c.1390G> A (p.Asp464Asn) single nucleotide variant Uncertain significance rs397517264 GRCh37 Chromosome 7, 151262815: 151262815
32 PRKAG2 NM_016203.3(PRKAG2): c.1390G> A (p.Asp464Asn) single nucleotide variant Uncertain significance rs397517264 GRCh38 Chromosome 7, 151565729: 151565729
33 PRKAG2 NM_016203.3(PRKAG2): c.1623T> C (p.Ile541=) single nucleotide variant Benign/Likely benign rs28763998 GRCh37 Chromosome 7, 151257665: 151257665
34 PRKAG2 NM_016203.3(PRKAG2): c.1623T> C (p.Ile541=) single nucleotide variant Benign/Likely benign rs28763998 GRCh38 Chromosome 7, 151560579: 151560579
35 PRKAG2 NM_016203.3(PRKAG2): c.207G> A (p.Pro69=) single nucleotide variant Benign/Likely benign rs144384573 GRCh37 Chromosome 7, 151478497: 151478497
36 PRKAG2 NM_016203.3(PRKAG2): c.207G> A (p.Pro69=) single nucleotide variant Benign/Likely benign rs144384573 GRCh38 Chromosome 7, 151781411: 151781411
37 PRKAG2 NM_016203.3(PRKAG2): c.240C> A (p.Gly80=) single nucleotide variant Conflicting interpretations of pathogenicity rs142482217 GRCh37 Chromosome 7, 151478464: 151478464
38 PRKAG2 NM_016203.3(PRKAG2): c.240C> A (p.Gly80=) single nucleotide variant Conflicting interpretations of pathogenicity rs142482217 GRCh38 Chromosome 7, 151781378: 151781378
39 PRKAG2 NM_016203.3(PRKAG2): c.425C> T (p.Thr142Ile) single nucleotide variant Uncertain significance rs397517270 GRCh37 Chromosome 7, 151478279: 151478279
40 PRKAG2 NM_016203.3(PRKAG2): c.425C> T (p.Thr142Ile) single nucleotide variant Uncertain significance rs397517270 GRCh38 Chromosome 7, 151781193: 151781193
41 PRKAG2 NM_016203.3(PRKAG2): c.59G> T (p.Ser20Ile) single nucleotide variant Benign/Likely benign rs116605521 GRCh37 Chromosome 7, 151573647: 151573647
42 PRKAG2 NM_016203.3(PRKAG2): c.59G> T (p.Ser20Ile) single nucleotide variant Benign/Likely benign rs116605521 GRCh38 Chromosome 7, 151876562: 151876562
43 PRKAG2 NM_016203.3(PRKAG2): c.620C> G (p.Ser207Cys) single nucleotide variant Uncertain significance rs397517277 GRCh37 Chromosome 7, 151372570: 151372570
44 PRKAG2 NM_016203.3(PRKAG2): c.620C> G (p.Ser207Cys) single nucleotide variant Uncertain significance rs397517277 GRCh38 Chromosome 7, 151675484: 151675484
45 PRKAG2 NM_016203.3(PRKAG2): c.912G> A (p.Ala304=) single nucleotide variant Conflicting interpretations of pathogenicity rs145029525 GRCh37 Chromosome 7, 151273491: 151273491
46 PRKAG2 NM_016203.3(PRKAG2): c.912G> A (p.Ala304=) single nucleotide variant Conflicting interpretations of pathogenicity rs145029525 GRCh38 Chromosome 7, 151576405: 151576405
47 KCNQ1 NM_000218.2(KCNQ1): c.1189C> T (p.Arg397Trp) single nucleotide variant Conflicting interpretations of pathogenicity rs199472776 GRCh37 Chromosome 11, 2608860: 2608860
48 KCNQ1 NM_000218.2(KCNQ1): c.1189C> T (p.Arg397Trp) single nucleotide variant Conflicting interpretations of pathogenicity rs199472776 GRCh38 Chromosome 11, 2587630: 2587630
49 KCNQ1 NM_000218.2(KCNQ1): c.724G> A (p.Asp242Asn) single nucleotide variant Pathogenic/Likely pathogenic rs199472712 GRCh37 Chromosome 11, 2593283: 2593283
50 KCNQ1 NM_000218.2(KCNQ1): c.724G> A (p.Asp242Asn) single nucleotide variant Pathogenic/Likely pathogenic rs199472712 GRCh38 Chromosome 11, 2572053: 2572053

Expression for Wolff-Parkinson-White Syndrome

Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for Wolff-Parkinson-White Syndrome

Pathways related to Wolff-Parkinson-White Syndrome according to KEGG:

38
# Name Kegg Source Accession
1 Insulin signaling pathway hsa04910
2 Adipocytokine signaling pathway hsa04920
3 Hypertrophic cardiomyopathy (HCM) hsa05410

Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 MYH7 NPPB PRKAA1 PRKAA2 PRKAG2 PRKAG3
2
Show member pathways
12.42 PRKAA1 PRKAA2 PRKAG2 PRKAG3
3 12.42 CBS PRKAA1 PRKAA2 PRKAG2 PRKAG3
4
Show member pathways
12.37 BMP2 MYH7 NKX2-5 NPPB
5
Show member pathways
12.34 PRKAA1 PRKAA2 PRKAG2 PRKAG3
6
Show member pathways
12.32 PRKAA1 PRKAA2 PRKAG2 PRKAG3
7
Show member pathways
12.13 PRKAA1 PRKAA2 PRKAG2 PRKAG3
8 12.12 PRKAA1 PRKAA2 PRKAG2 PRKAG3
9
Show member pathways
12.08 PRKAA1 PRKAA2 PRKAG2 PRKAG3
10
Show member pathways
12.05 PRKAA1 PRKAA2 PRKAG2 PRKAG3
11
Show member pathways
12.03 PRKAA1 PRKAA2 PRKAG2 PRKAG3
12
Show member pathways
11.99 PRKAA1 PRKAA2 PRKAG2 PRKAG3
13
Show member pathways
11.87 PRKAA1 PRKAA2 PRKAG2 PRKAG3
14 11.86 JAG1 PRKAA1 PRKAA2 PRKAG2 PRKAG3
15 11.82 PRKAA1 PRKAA2 PRKAG2 PRKAG3
16 11.71 PRKAA1 PRKAA2 PRKAG2 PRKAG3
17
Show member pathways
11.68 MYH7 PRKAA1 PRKAA2 PRKAG2 PRKAG3 TNNI3
18 11.62 PRKAA1 PRKAA2 PRKAG2 PRKAG3
19 11.57 PRKAA1 PRKAA2 PRKAG2 PRKAG3
20 11.51 NKX2-5 TBX20 TNNI3
21 11.5 MYH7 PRKAA2 PRKAG2 PRKAG3
22 11.42 BMP2 NKX2-5 TBX20
23 11.39 PRKAA1 PRKAA2 PRKAG2 PRKAG3
24
Show member pathways
11.19 PRKAA1 PRKAA2 PRKAG2 PRKAG3
25 11.01 PRKAA1 PRKAA2 PRKAG2 PRKAG3
26 10.65 PRKAA2 PRKAG2
27 10.27 BMP2 MYH7 NKX2-5 NPPB

GO Terms for Wolff-Parkinson-White Syndrome

Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin complex GO:0005861 8.96 TNNI3 TNNT1
2 nucleotide-activated protein kinase complex GO:0031588 8.92 PRKAA1 PRKAA2 PRKAG2 PRKAG3

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 fatty acid metabolic process GO:0006631 9.83 PRKAA1 PRKAA2 PRKAG2 PRKAG3
2 cell cycle arrest GO:0007050 9.8 PRKAA1 PRKAA2 PRKAG2 PRKAG3
3 inner ear development GO:0048839 9.73 BMP2 JAG1 KCNQ1
4 muscle contraction GO:0006936 9.73 MYH7 TBX20 TNNI3 TNNT1
5 aortic valve morphogenesis GO:0003180 9.67 JAG1 TBX20
6 embryonic heart tube development GO:0035050 9.66 NKX2-5 TBX20
7 lipid biosynthetic process GO:0008610 9.65 PRKAA1 PRKAA2
8 positive regulation of glycolytic process GO:0045821 9.65 PRKAA1 PRKAA2
9 regulation of muscle contraction GO:0006937 9.65 TNNI3 TNNT1
10 muscle filament sliding GO:0030049 9.65 MYH7 TNNI3 TNNT1
11 cardiovascular system development GO:0072358 9.64 KCNQ1 NKX2-5
12 cellular response to prostaglandin E stimulus GO:0071380 9.64 PRKAA1 PRKAA2
13 endocardial cushion morphogenesis GO:0003203 9.63 BMP2 TBX20
14 fatty acid homeostasis GO:0055089 9.63 PRKAA1 PRKAA2
15 sterol biosynthetic process GO:0016126 9.63 PRKAA1 PRKAA2 PRKAG2
16 striated muscle contraction GO:0006941 9.62 MYH7 TNNI3
17 adult heart development GO:0007512 9.62 MYH7 NKX2-5
18 heart contraction GO:0060047 9.61 NKX2-5 TNNI3
19 cardiac right ventricle morphogenesis GO:0003215 9.61 JAG1 TBX20
20 atrial septum morphogenesis GO:0060413 9.6 NKX2-5 TBX20
21 cellular response to nutrient levels GO:0031669 9.59 PRKAA1 PRKAA2
22 transition between fast and slow fiber GO:0014883 9.58 MYH7 TNNT1
23 regulation of fatty acid biosynthetic process GO:0042304 9.58 PRKAA2 PRKAG2
24 positive regulation of cellular protein localization GO:1903829 9.57 PRKAA1 PRKAA2
25 macroautophagy GO:0016236 9.56 PRKAA1 PRKAA2 PRKAG2 PRKAG3
26 negative regulation of tubulin deacetylation GO:1904428 9.55 PRKAA1 PRKAA2
27 regulation of protein serine/threonine kinase activity GO:0071900 9.54 PRKAG2 PRKAG3
28 histone-serine phosphorylation GO:0035404 9.51 PRKAA1 PRKAA2
29 skeletal muscle contraction GO:0003009 9.5 MYH7 TNNI3 TNNT1
30 positive regulation of peptidyl-lysine acetylation GO:2000758 9.4 PRKAA1 PRKAA2
31 regulation of stress granule assembly GO:0062028 9.37 PRKAA1 PRKAA2
32 cardiac muscle tissue morphogenesis GO:0055008 9.33 BMP2 NKX2-5 TBX20
33 fatty acid biosynthetic process GO:0006633 9.26 PRKAA1 PRKAA2 PRKAG2 PRKAG3
34 cardiac muscle contraction GO:0060048 9.02 KCNQ1 MYH7 NKX2-5 TNNI3 TNNT1
35 protein phosphorylation GO:0006468 10.06 BMP2 PRKAA1 PRKAA2 PRKAG2 PRKAG3

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 histone serine kinase activity GO:0035174 9.37 PRKAA1 PRKAA2
2 adenyl ribonucleotide binding GO:0032559 9.32 PRKAG2 PRKAG3
3 troponin T binding GO:0031014 9.26 TNNI3 TNNT1
4 [acetyl-CoA carboxylase] kinase activity GO:0050405 9.16 PRKAA1 PRKAA2
5 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity GO:0047322 8.96 PRKAA1 PRKAA2
6 AMP-activated protein kinase activity GO:0004679 8.92 PRKAA1 PRKAA2 PRKAG2 PRKAG3

Sources for Wolff-Parkinson-White Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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