MCID: WLF001
MIFTS: 59

Wolff-Parkinson-White Syndrome

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases

Aliases & Classifications for Wolff-Parkinson-White Syndrome

MalaCards integrated aliases for Wolff-Parkinson-White Syndrome:

Name: Wolff-Parkinson-White Syndrome 57 12 53 25 75 29 13 55 6 44 15 73
Wolff-Parkinson-White Pattern 12 29 6 40
Wpw Syndrome 57 53 25
Ventricular Familial Preexcitation Syndrome 53 75
Anomalous Atrioventricular Excitation 12 73
Preexcitation Syndrome 53 73
Auriculoventricular Accessory Pathway Syndrome 53
Ventricular Pre-Excitation with Arrhythmia 25
Anomalous Ventricular Excitation Syndrome 53
False Bundle Branch Block Syndrome 53
Wolff-Parkinson-White Syndrome 37
Ventricular Preexcitation 73
Anomalous a-V Excitation 12
Wpws 75

Characteristics:

OMIM:

57
Inheritance:
? autosomal dominant factor


Classifications:



Summaries for Wolff-Parkinson-White Syndrome

NIH Rare Diseases : 53 Wolff-Parkinson-White syndrome causes a problem with the rate or rhythm of the heartbeat (arrhythmia). People with the syndrome are born with a heart abnormality that affects the coordinated movement of electrical signals through the heart. This leads to an abnormally fast heartbeat (tachycardia) and other arrhythmias. The most common arrhythmia associated with Wolff-Parkinson-White syndrome is paroxysmal supraventricular tachycardia. The syndrome is especially common in people of Chinese descent. In most cases, the cause of Wolff-Parkinson-White syndrome is unknown. A small percentage of cases are caused by genetic changes (mutations or pathogenic variants) in the PRKAG2 gene. These cases appear to be inherited in an autosomal dominant manner. A diagnosis of the syndrome is based on an electrocardiogram (ECG) or Holter test that shows episodes of tachycardia. Treatment for the syndrome may depend on the severity of symptoms but can include medications or surgery.

MalaCards based summary : Wolff-Parkinson-White Syndrome, also known as wolff-parkinson-white pattern, is related to cardiomyopathy, familial hypertrophic, 6 and atrial standstill 1. An important gene associated with Wolff-Parkinson-White Syndrome is PRKAG2 (Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2), and among its related pathways/superpathways are Insulin signaling pathway and Adipocytokine signaling pathway. The drug Menthol has been mentioned in the context of this disorder. Affiliated tissues include heart, testes and thyroid, and related phenotypes are sudden cardiac death and cardiomyopathy

UniProtKB/Swiss-Prot : 75 Wolff-Parkinson-White syndrome: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia.

Genetics Home Reference : 25 Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical pathways in the heart that cause a disruption of the heart's normal rhythm (arrhythmia).

Wikipedia : 76 Wolff–Parkinson–White syndrome (WPWS) is a disorder due to a specific type of problem with the... more...

Description from OMIM: 194200

Related Diseases for Wolff-Parkinson-White Syndrome

Diseases related to Wolff-Parkinson-White Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 99)
# Related Disease Score Top Affiliating Genes
1 cardiomyopathy, familial hypertrophic, 6 33.6 PRKAG2 TNNI3
2 atrial standstill 1 30.6 MYH7 PRKAG2 TNNI3
3 hypertrophic cardiomyopathy 30.5 MYH7 PRKAG2 TNNI3 TNNT1
4 cardiac conduction defect 29.8 KCNQ1 MYH7
5 dilated cardiomyopathy 28.4 KCNQ1 MYH7 TBX20 TNNI3 TNNT1
6 heart disease 27.5 JAG1 KCNQ1 MYH7 TBX20 TNNI3
7 cardiomyopathy, infantile histiocytoid 11.3
8 20p12.3 microdeletion syndrome 11.3
9 myoclonic epilepsy associated with ragged-red fibers 11.0
10 atrial fibrillation 10.9
11 myocardial infarction 10.7
12 ventricular fibrillation, paroxysmal familial, 1 10.6
13 progressive familial heart block, type ia 10.5
14 phosphorylase kinase deficiency 10.4 PRKAA2 PRKAG2
15 aging 10.4
16 brugada syndrome 10.4
17 syncope 10.4
18 corneal dystrophy, subepithelial mucinous 10.4 COL5A1 TNNI3
19 progressive familial heart block, type ib 10.3
20 right bundle branch block 10.3
21 tuberous sclerosis 10.3
22 intermediate coronary syndrome 10.3 TNNI3 TNNT1
23 acute myocardial infarction 10.3
24 cardiac arrest 10.3
25 depression 10.3
26 aneurysm 10.3
27 restrictive cardiomyopathy 10.2 MYH7 TNNI3 TNNT1
28 tricuspid atresia 10.2
29 congestive heart failure 10.2
30 endocarditis 10.2
31 epilepsy 10.2
32 atrial heart septal defect 10.2
33 optic nerve disease 10.2
34 lactic acidosis 10.2
35 thyroiditis 10.2
36 myocarditis 10.2
37 neuropathy 10.2
38 dextrocardia 10.2
39 muscular dystrophy 10.2
40 double discordia 10.2
41 transposition of the great arteries 10.2
42 encephalopathy 10.2
43 familial isolated dilated cardiomyopathy 10.1 MYH7 TNNI3
44 spondyloarthropathy 1 10.0
45 total anomalous pulmonary venous return 1 10.0
46 alagille syndrome 1 10.0
47 hypokalemic periodic paralysis, type 1 10.0
48 schizophrenia 10.0
49 scleroderma, familial progressive 10.0
50 tuberous sclerosis 1 10.0

Comorbidity relations with Wolff-Parkinson-White Syndrome via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease

Graphical network of the top 20 diseases related to Wolff-Parkinson-White Syndrome:



Diseases related to Wolff-Parkinson-White Syndrome

Symptoms & Phenotypes for Wolff-Parkinson-White Syndrome

Symptoms via clinical synopsis from OMIM:

57
Cardiac:
palpitations
short pr interval and prolonged qrs, with slurred-up stroke of the r wave (delta wave) on ekg
paroxysmal supraventricular tachycardia
paroxysmal atrial fibrillation
familial cardiomyopathy
more

Clinical features from OMIM:

194200

Human phenotypes related to Wolff-Parkinson-White Syndrome:

32 (show all 10)
# Description HPO Frequency HPO Source Accession
1 sudden cardiac death 32 HP:0001645
2 cardiomyopathy 32 HP:0001638
3 wolff-parkinson-white syndrome 32 HP:0001716
4 stroke 32 HP:0001297
5 palpitations 32 HP:0001962
6 shortened pr interval 32 HP:0005165
7 paroxysmal supraventricular tachycardia 32 HP:0004763
8 paroxysmal atrial fibrillation 32 HP:0004757
9 prolonged qrs complex 32 HP:0006677
10 ventricular preexcitation with multiple accessory pathways 32 HP:0006684

MGI Mouse Phenotypes related to Wolff-Parkinson-White Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.56 COL5A1 DNAAF3 JAG1 KCNQ1 MYH7 PRKAG2
2 muscle MP:0005369 9.23 PRKAG2 TBX20 TNNI3 TNNT1 JAG1 KCNQ1

Drugs & Therapeutics for Wolff-Parkinson-White Syndrome

Drugs for Wolff-Parkinson-White Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved 2216-51-5 16666

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Long-term Safety, Tolerability and Efficacy of BAF312 Given Orally in Patients With Relapsing-remitting Multiple Sclerosis Completed NCT01185821 Phase 2 BAF312
2 Routine Mini-invasive Electrophysiology Study for Patients Feeling Tachycardia, With a Negative Holter ECG Completed NCT00251121 Not Applicable
3 Risk Assessment in Patients With Symptomatic- and Asymptomatic Preexcitation Recruiting NCT03301935
4 Stress ECG Test for the Evaluation of the Risk of Sudden Cardiac Death in a Paediatric Cohort With WPW Pattern Enrolling by invitation NCT03207373 Not Applicable
5 Management of Supraventricular Tachycardia of Children Not yet recruiting NCT03528616 adenosine,Propranolol,flecainide, amiodarone, propranolol, digoxin and procainamide.
6 Wolff-Parkinson-White Syndrome Anterograde Refractory Period of Accessory Duct Terminated NCT00873470 Not Applicable

Search NIH Clinical Center for Wolff-Parkinson-White Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: wolff-parkinson-white syndrome

Genetic Tests for Wolff-Parkinson-White Syndrome

Genetic tests related to Wolff-Parkinson-White Syndrome:

# Genetic test Affiliating Genes
1 Wolff-Parkinson-White Pattern 29 PRKAG2
2 Wolff-Parkinson-White Syndrome 29

Anatomical Context for Wolff-Parkinson-White Syndrome

MalaCards organs/tissues related to Wolff-Parkinson-White Syndrome:

41
Heart, Testes, Thyroid, Spinal Cord, Uterus, Placenta, Atrioventricular Node

Publications for Wolff-Parkinson-White Syndrome

Articles related to Wolff-Parkinson-White Syndrome:

(show top 50) (show all 667)
# Title Authors Year
1
A case of Wolff-Parkinson-White syndrome presenting spontaneous mutual frequent transition between atrioventricular reciprocating tachycardia and atrioventricular nodal re-entrant tachycardia. ( 29478804 )
2018
2
Pharmacologic therapy with flecainide for asymptomatic Wolff-Parkinson-White syndrome in an infant with severe left ventricular dyssynchrony. ( 29848398 )
2018
3
Molecular Pathogenesis of Familial Wolff-Parkinson-White Syndrome. ( 29593177 )
2018
4
Complications of Radiofrequency Ablation for Supraventricular Tachycardia in the Wolff-Parkinson-White Syndrome Associated With Noncompaction Cardiomyopathy. ( 29706203 )
2018
5
Isolated Wolff-Parkinson-White syndrome in identical twins. ( 29755940 )
2018
6
Wolff-Parkinson-White Syndrome in a Patient with Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Syndrome Mimicking Juvenile Myoclonic Epilepsy. ( 29629547 )
2018
7
Wolff-Parkinson-White syndrome and noncompaction in Leber's hereditary optic neuropathy due to the variant m.3460G>A. ( 29562793 )
2018
8
Late restored cardiac function after successful resynchronization by right posterior accessory pathway ablation in Wolff-Parkinson-White syndrome associated dilated cardiomyopathy. ( 29452709 )
2018
9
Electrophysiological effects of desflurane in children with Wolff-Parkinson-White syndrome: a randomized crossover study. ( 29068040 )
2018
10
MY APPROACH to the Athlete With Wolff-Parkinson-White Syndrome (WPW). ( 29032933 )
2018
11
Altered myocardial characteristics of the preexcited segment in Wolff-Parkinson-White syndrome: A pilot study with cardiac magnetic resonance imaging. ( 29856866 )
2018
12
Characterisation of three-dimensional mapping in Wolff-Parkinson-White syndrome with septal aneurysmal dyskinesis. ( 28847328 )
2017
13
Radiofrequency ablation of accessory pathways in patients with the Wolff-Parkinson-White syndrome: long-term risk of mortality and coronary events. ( 28605443 )
2017
14
Wolff-Parkinson-White Syndrome Associated With a Fistula Between the Right Atrial Appendage and Right Ventricle. ( 28214246 )
2017
15
Reversal of Wolff-Parkinson-White Syndrome induced dilated cardiomyopathy via resynchronization and subsequent accessory pathway ablation. ( 29238369 )
2017
16
A Case of Multiple Cardiovascular and Tracheal Anomalies Presented with Wolff-Parkinson-White Syndrome in a Middle-aged Adult. ( 29115093 )
2017
17
Accessory pathway location affects brain natriuretic peptide level in patients with Wolff-Parkinson-White syndrome. ( 27815796 )
2017
18
Wolff-Parkinson-White syndrome: lessons learnt and lessons remaining. ( 28084962 )
2017
19
Wolff-Parkinson-White Syndrome with Ventricular Hypertrophy in a Brazilian Family. ( 28690312 )
2017
20
Successful ablation of a right atrium-axillary ventricular accessory pathway associated with Wolff-Parkinson-White syndrome. ( 28543607 )
2017
21
Atrial fibrillation associated with Wolff-Parkinson-White syndrome in a patient with concomitant Brugada syndrome. ( 28491758 )
2017
22
The impact of left ventricular deformation and dyssynchrony on improvement of left ventricular ejection fraction following radiofrequency catheter ablation in Wolff-Parkinson-White syndrome: A comprehensive study by speckle tracking echocardiography. ( 28929532 )
2017
23
Supraventricular tachycardia in a trauma patient masquerading as a Wolff-Parkinson-White syndrome. ( 28927735 )
2017
24
The use of sugammadex in a pregnant patient with Wolff-Parkinson-White syndrome. ( 27555124 )
2016
25
Spinal Anaesthesia is Safe in a Patient with Wolff-Parkinson-White Syndrome Undergoing Evacuation of Molar Pregnancy. ( 27042562 )
2016
26
The Wolff-Parkinson-White Syndrome: A Test Bed for the Assessment of Myocardial Dyssynchrony? ( 27307557 )
2016
27
The impact of B-type natriuretic peptide levels on the suppression of accompanying atrial fibrillation in Wolff-Parkinson-White syndrome patients after accessory pathway ablation. ( 26917195 )
2016
28
Wolff-Parkinson-White Syndrome: A Stepwise Deterioration to Sudden Death. ( 26719390 )
2016
29
Tachyarrhythmia in Wolff-Parkinson-White Syndrome. ( 27429700 )
2016
30
Physiological Expression of AMPKI^2RG Mutation Causes Wolff-Parkinson-White Syndrome and Induces Kidney Injury in Mice. ( 27621313 )
2016
31
Wolff-Parkinson-White syndrome: a single exercise stress test might be misleading. ( 27869041 )
2016
32
Localization Of Accessory Pathway In Patients With Wolff-Parkinson-White Syndrome From Surface Ecg Using Arruda Algorithm. ( 28712209 )
2016
33
Wolff-Parkinson-White Syndrome in a Term Infant Presenting With Cardiopulmonary Arrest. ( 26742096 )
2016
34
Flecainide-induced incessant orthodromic atrioventricular reentrant tachycardia in Wolff-Parkinson-White syndrome: Uneven depression of accessory pathway conduction. ( 28491747 )
2016
35
PRKAG3 polymorphisms associated with sporadic Wolff-Parkinson-White syndrome among a Taiwanese population. ( 27866917 )
2016
36
Detecting Regional Myocardial Abnormalities in Patients With Wolff-Parkinson-White Syndrome With the Use of ECG-Gated Cardiac MDCT. ( 26866341 )
2016
37
Noninvasive Localization of Accessory Pathways in Wolff-Parkinson-White Syndrome by Three-Dimensional Speckle Tracking Echocardiography. ( 27307551 )
2016
38
Depression masquerading as chest pain in a patient with Wolff Parkinson White syndrome. ( 27738505 )
2016
39
Spontaneous Transition of Double Tachycardias with Atrial Fusion in a Patient with Wolff-Parkinson-White Syndrome. ( 27482269 )
2016
40
Comparison of the accuracy of three algorithms in predicting accessory pathways among adult Wolff-Parkinson-White syndrome patients. ( 26384677 )
2015
41
Response to letter regarding article, "Wolff-Parkinson-White syndrome in the era of catheter ablation: insights from a registry study of 2169 patients". ( 25986452 )
2015
42
Treatment of Wolff-Parkinson-White Syndrome With a Thoracoscopic Surgical Procedure. ( 26140800 )
2015
43
Extracorporeal life support for cardiac arrest in a 13-year-old girl caused by Wolff-Parkinson-White syndrome. ( 26314214 )
2015
44
A young patient with atypical type-B Wolff-Parkinson-White syndrome accompanied by left ventricular dysfunction. ( 26336525 )
2015
45
Variable primary phenotypic manifestations in a rare familial form of Wolff-Parkinson-White syndrome and hypertrophic cardiomyopathy. ( 26333379 )
2015
46
Thyroid storm in a patient with Wolff-Parkinson-White syndrome. ( 26670895 )
2015
47
Intermittent versus Persistent Wolff-Parkinson-White Syndrome in Children: Electrophysiologic Properties and Clinical Outcomes. ( 26256551 )
2015
48
Exome analysis of a family with Wolff-Parkinson-White syndrome identifies a novel disease locus. ( 26284702 )
2015
49
Wolff-Parkinson-White syndrome with bundle branch and fascicular block: The diagnostic clue of electrocardiogram. ( 25497533 )
2015
50
Swallowing-induced atrial tachyarrhythmias successfully ablated at the left posterior interatrial septum in patient with wolff-Parkinson-white syndrome. ( 26023316 )
2015

Variations for Wolff-Parkinson-White Syndrome

UniProtKB/Swiss-Prot genetic disease variations for Wolff-Parkinson-White Syndrome:

75
# Symbol AA change Variation ID SNP ID
1 PRKAG2 p.Arg302Gln VAR_013264 rs121908987
2 PRKAG2 p.Arg531Gly VAR_032909 rs121908990

ClinVar genetic disease variations for Wolff-Parkinson-White Syndrome:

6
(show top 50) (show all 258)
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC26A4 NM_000441.1(SLC26A4): c.85G> C (p.Glu29Gln) single nucleotide variant Pathogenic/Likely pathogenic rs111033205 GRCh37 Chromosome 7, 107302171: 107302171
2 SLC26A4 NM_000441.1(SLC26A4): c.85G> C (p.Glu29Gln) single nucleotide variant Pathogenic/Likely pathogenic rs111033205 GRCh38 Chromosome 7, 107661726: 107661726
3 PRKAG2 NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln) single nucleotide variant Pathogenic rs121908987 GRCh37 Chromosome 7, 151273498: 151273498
4 PRKAG2 NM_016203.3(PRKAG2): c.905G> A (p.Arg302Gln) single nucleotide variant Pathogenic rs121908987 GRCh38 Chromosome 7, 151576412: 151576412
5 MYH7 NM_000257.3(MYH7): c.2389G> A (p.Ala797Thr) single nucleotide variant Pathogenic/Likely pathogenic rs3218716 GRCh37 Chromosome 14, 23894525: 23894525
6 MYH7 NM_000257.3(MYH7): c.2389G> A (p.Ala797Thr) single nucleotide variant Pathogenic/Likely pathogenic rs3218716 GRCh38 Chromosome 14, 23425316: 23425316
7 KCNQ1 NM_000218.2(KCNQ1): c.724G> A (p.Asp242Asn) single nucleotide variant Pathogenic/Likely pathogenic rs199472712 GRCh37 Chromosome 11, 2593283: 2593283
8 KCNQ1 NM_000218.2(KCNQ1): c.724G> A (p.Asp242Asn) single nucleotide variant Pathogenic/Likely pathogenic rs199472712 GRCh38 Chromosome 11, 2572053: 2572053
9 PRKAG2 NM_016203.3(PRKAG2): c.202G> A (p.Gly68Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs730880970 GRCh38 Chromosome 7, 151781416: 151781416
10 PRKAG2 NM_016203.3(PRKAG2): c.202G> A (p.Gly68Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs730880970 GRCh37 Chromosome 7, 151478502: 151478502
11 CACNA1C NM_000719.6(CACNA1C): c.1485C> A (p.His495Gln) single nucleotide variant Uncertain significance rs373335068 GRCh37 Chromosome 12, 2666120: 2666120
12 CACNA1C NM_000719.6(CACNA1C): c.1485C> A (p.His495Gln) single nucleotide variant Uncertain significance rs373335068 GRCh38 Chromosome 12, 2556954: 2556954
13 CACNA1C NM_001129842.1(CACNA1C): c.2579G> A (p.Arg860Gln) single nucleotide variant Uncertain significance rs730880056 GRCh37 Chromosome 12, 2702427: 2702427
14 CACNA1C NM_001129842.1(CACNA1C): c.2579G> A (p.Arg860Gln) single nucleotide variant Uncertain significance rs730880056 GRCh38 Chromosome 12, 2593261: 2593261
15 SNTA1 NM_003098.2(SNTA1): c.1088A> C (p.Glu363Ala) single nucleotide variant Uncertain significance rs147964932 GRCh37 Chromosome 20, 31998090: 31998090
16 SNTA1 NM_003098.2(SNTA1): c.1088A> C (p.Glu363Ala) single nucleotide variant Uncertain significance rs147964932 GRCh38 Chromosome 20, 33410284: 33410284
17 LAMA4 NM_002290.4(LAMA4): c.2377C> T (p.Arg793Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs202184174 GRCh37 Chromosome 6, 112466091: 112466091
18 LAMA4 NM_002290.4(LAMA4): c.2377C> T (p.Arg793Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs202184174 GRCh38 Chromosome 6, 112144889: 112144889
19 RYR2 NM_001035.2(RYR2): c.11919T> G (p.Asp3973Glu) single nucleotide variant Uncertain significance rs370103782 GRCh37 Chromosome 1, 237944903: 237944903
20 RYR2 NM_001035.2(RYR2): c.11919T> G (p.Asp3973Glu) single nucleotide variant Uncertain significance rs370103782 GRCh38 Chromosome 1, 237781603: 237781603
21 SCN5A NM_198056.2(SCN5A): c.1705C> G (p.Arg569Gly) single nucleotide variant Uncertain significance rs199473576 GRCh37 Chromosome 3, 38645388: 38645388
22 SCN5A NM_198056.2(SCN5A): c.1705C> G (p.Arg569Gly) single nucleotide variant Uncertain significance rs199473576 GRCh38 Chromosome 3, 38603897: 38603897
23 JUP NM_002230.2(JUP): c.773A> G (p.Glu258Gly) single nucleotide variant Uncertain significance rs794729052 GRCh37 Chromosome 17, 39923767: 39923767
24 JUP NM_002230.2(JUP): c.773A> G (p.Glu258Gly) single nucleotide variant Uncertain significance rs794729052 GRCh38 Chromosome 17, 41767515: 41767515
25 PRKAG2 NM_016203.3(PRKAG2): c.1310C> G (p.Ala437Gly) single nucleotide variant Uncertain significance rs762111172 GRCh38 Chromosome 7, 151565809: 151565809
26 PRKAG2 NM_016203.3(PRKAG2): c.1310C> G (p.Ala437Gly) single nucleotide variant Uncertain significance rs762111172 GRCh37 Chromosome 7, 151262895: 151262895
27 JUP NM_002230.2(JUP): c.578T> C (p.Met193Thr) single nucleotide variant Uncertain significance rs139496777 GRCh37 Chromosome 17, 39925350: 39925350
28 JUP NM_002230.2(JUP): c.578T> C (p.Met193Thr) single nucleotide variant Uncertain significance rs139496777 GRCh38 Chromosome 17, 41769098: 41769098
29 TTN NM_133432.3(TTN): c.65863C> T (p.Arg21955Ter) single nucleotide variant Likely pathogenic rs869312065 GRCh38 Chromosome 2, 178548943: 178548943
30 TTN NM_133432.3(TTN): c.65863C> T (p.Arg21955Ter) single nucleotide variant Likely pathogenic rs869312065 GRCh37 Chromosome 2, 179413670: 179413670
31 PRKAG2 NM_016203.3(PRKAG2): c.-26C> T single nucleotide variant Likely benign rs66628686 GRCh37 Chromosome 7, 151573731: 151573731
32 PRKAG2 NM_016203.3(PRKAG2): c.-26C> T single nucleotide variant Likely benign rs66628686 GRCh38 Chromosome 7, 151876646: 151876646
33 TCAP NM_003673.3(TCAP): c.97C> T (p.Arg33Trp) single nucleotide variant Uncertain significance rs145524909 GRCh37 Chromosome 17, 37821709: 37821709
34 TCAP NM_003673.3(TCAP): c.97C> T (p.Arg33Trp) single nucleotide variant Uncertain significance rs145524909 GRCh38 Chromosome 17, 39665456: 39665456
35 RYR2 NM_001035.2(RYR2): c.3181G> A (p.Gly1061Ser) single nucleotide variant Uncertain significance rs747447414 GRCh37 Chromosome 1, 237713958: 237713958
36 RYR2 NM_001035.2(RYR2): c.3181G> A (p.Gly1061Ser) single nucleotide variant Uncertain significance rs747447414 GRCh38 Chromosome 1, 237550658: 237550658
37 PRKAG2 NM_016203.3(PRKAG2): c.*1061G> A single nucleotide variant Likely benign rs7429 GRCh37 Chromosome 7, 151253226: 151253226
38 PRKAG2 NM_016203.3(PRKAG2): c.*1061G> A single nucleotide variant Likely benign rs7429 GRCh38 Chromosome 7, 151556140: 151556140
39 PRKAG2 NM_016203.3(PRKAG2): c.*1041dupC duplication Uncertain significance rs886062093 GRCh37 Chromosome 7, 151253246: 151253246
40 PRKAG2 NM_016203.3(PRKAG2): c.*1041dupC duplication Uncertain significance rs886062093 GRCh38 Chromosome 7, 151556160: 151556160
41 PRKAG2 NM_016203.3(PRKAG2): c.*1040dupT duplication Uncertain significance rs773585778 GRCh37 Chromosome 7, 151253247: 151253247
42 PRKAG2 NM_016203.3(PRKAG2): c.*1040dupT duplication Uncertain significance rs773585778 GRCh38 Chromosome 7, 151556161: 151556161
43 PRKAG2 NM_016203.3(PRKAG2): c.*1029dupG duplication Uncertain significance rs56898021 GRCh37 Chromosome 7, 151253258: 151253258
44 PRKAG2 NM_016203.3(PRKAG2): c.*1029dupG duplication Uncertain significance rs56898021 GRCh38 Chromosome 7, 151556172: 151556172
45 PRKAG2 NM_016203.3(PRKAG2): c.*1021_*1022delTGinsGT indel Uncertain significance rs886062094 GRCh37 Chromosome 7, 151253265: 151253266
46 PRKAG2 NM_016203.3(PRKAG2): c.*1021_*1022delTGinsGT indel Uncertain significance rs886062094 GRCh38 Chromosome 7, 151556179: 151556180
47 PRKAG2 NM_016203.3(PRKAG2): c.*612G> A single nucleotide variant Uncertain significance rs371404960 GRCh37 Chromosome 7, 151253675: 151253675
48 PRKAG2 NM_016203.3(PRKAG2): c.*612G> A single nucleotide variant Uncertain significance rs371404960 GRCh38 Chromosome 7, 151556589: 151556589
49 PRKAG2 NM_016203.3(PRKAG2): c.*350C> A single nucleotide variant Uncertain significance rs886062099 GRCh37 Chromosome 7, 151253937: 151253937
50 PRKAG2 NM_016203.3(PRKAG2): c.*350C> A single nucleotide variant Uncertain significance rs886062099 GRCh38 Chromosome 7, 151556851: 151556851

Expression for Wolff-Parkinson-White Syndrome

Search GEO for disease gene expression data for Wolff-Parkinson-White Syndrome.

Pathways for Wolff-Parkinson-White Syndrome

Pathways related to Wolff-Parkinson-White Syndrome according to KEGG:

37
# Name Kegg Source Accession
1 Insulin signaling pathway hsa04910
2 Adipocytokine signaling pathway hsa04920
3 Hypertrophic cardiomyopathy (HCM) hsa05410

Pathways related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 MYH7 PRKAA2 PRKAG2 PRKAG3
2 12.29 CBS PRKAA2 PRKAG2 PRKAG3
3
Show member pathways
12.01 PRKAA2 PRKAG2 PRKAG3
4 12 PRKAA2 PRKAG2 PRKAG3
5
Show member pathways
11.97 PRKAA2 PRKAG2 PRKAG3
6
Show member pathways
11.92 PRKAA2 PRKAG2 PRKAG3
7
Show member pathways
11.91 PRKAA2 PRKAG2 PRKAG3
8
Show member pathways
11.86 PRKAA2 PRKAG2 PRKAG3
9
Show member pathways
11.85 PRKAA2 PRKAG2 PRKAG3
10
Show member pathways
11.74 PRKAA2 PRKAG2 PRKAG3
11 11.7 PRKAA2 PRKAG2 PRKAG3
12 11.59 JAG1 PRKAA2 PRKAG2 PRKAG3
13 11.56 PRKAA2 PRKAG2 PRKAG3
14 11.47 PRKAA2 PRKAG2 PRKAG3
15 11.42 PRKAA2 PRKAG2 PRKAG3
16 11.26 PRKAA2 PRKAG2 PRKAG3
17
Show member pathways
11.26 MYH7 PRKAA2 PRKAG2 PRKAG3 TNNI3
18
Show member pathways
11.13 PRKAA2 PRKAG2 PRKAG3
19 11.05 MYH7 PRKAA2 PRKAG2 PRKAG3
20 10.99 PRKAA2 PRKAG2 PRKAG3
21 10.52 PRKAA2 PRKAG2

GO Terms for Wolff-Parkinson-White Syndrome

Cellular components related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin complex GO:0005861 8.96 TNNI3 TNNT1
2 nucleotide-activated protein kinase complex GO:0031588 8.8 PRKAA2 PRKAG2 PRKAG3

Biological processes related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 fatty acid metabolic process GO:0006631 9.73 PRKAA2 PRKAG2 PRKAG3
2 cell cycle arrest GO:0007050 9.71 PRKAA2 PRKAG2 PRKAG3
3 regulation of signal transduction by p53 class mediator GO:1901796 9.7 PRKAA2 PRKAG2 PRKAG3
4 macroautophagy GO:0016236 9.65 PRKAA2 PRKAG2 PRKAG3
5 sterol biosynthetic process GO:0016126 9.58 PRKAA2 PRKAG2
6 striated muscle contraction GO:0006941 9.57 MYH7 TNNI3
7 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.55 MYH7 TNNI3
8 regulation of macroautophagy GO:0016241 9.54 PRKAA2 PRKAG2 PRKAG3
9 regulation of muscle contraction GO:0006937 9.51 TNNI3 TNNT1
10 fatty acid biosynthetic process GO:0006633 9.5 PRKAA2 PRKAG2 PRKAG3
11 cardiac right ventricle morphogenesis GO:0003215 9.49 JAG1 TBX20
12 carnitine shuttle GO:0006853 9.46 PRKAA2 PRKAG2
13 muscle contraction GO:0006936 9.46 MYH7 TBX20 TNNI3 TNNT1
14 transition between fast and slow fiber GO:0014883 9.43 MYH7 TNNT1
15 muscle filament sliding GO:0030049 9.43 MYH7 TNNI3 TNNT1
16 regulation of fatty acid biosynthetic process GO:0042304 9.4 PRKAA2 PRKAG2
17 skeletal muscle contraction GO:0003009 9.13 MYH7 TNNI3 TNNT1
18 cardiac muscle contraction GO:0060048 8.92 KCNQ1 MYH7 TNNI3 TNNT1

Molecular functions related to Wolff-Parkinson-White Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin T binding GO:0031014 8.96 TNNI3 TNNT1
2 AMP-activated protein kinase activity GO:0004679 8.8 PRKAA2 PRKAG2 PRKAG3

Sources for Wolff-Parkinson-White Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
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69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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