MCID: WLF006
MIFTS: 33

Wolffian Duct Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Wolffian Duct Adenocarcinoma

MalaCards integrated aliases for Wolffian Duct Adenocarcinoma:

Name: Wolffian Duct Adenocarcinoma 12 15
Cervical Mesonephric Adenocarcinoma 12 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5368
NCIt 50 C40254
UMLS 72 C1516419

Summaries for Wolffian Duct Adenocarcinoma

Disease Ontology : 12 A cervical adenocarcinoma that has material basis in remnants of mesonephric ducts and is located anywhere along the length between the ovary and vagina in sites of remnant wolffian ducts.

MalaCards based summary : Wolffian Duct Adenocarcinoma, also known as cervical mesonephric adenocarcinoma, is related to adenocarcinoma and water-clear cell adenoma. An important gene associated with Wolffian Duct Adenocarcinoma is PAX8 (Paired Box 8), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Nanog in Mammalian ESC Pluripotency. Affiliated tissues include ovary, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Wolffian Duct Adenocarcinoma

Diseases related to Wolffian Duct Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 30.1 KRAS HRAS FGFR2
2 water-clear cell adenoma 10.5 PAX8 GATA3
3 sarcomatoid renal cell carcinoma 10.5 PAX8 GATA3
4 endosalpingiosis 10.5 WT1 PAX8
5 syringomyelia 10.4 NRAS FGFR2
6 urethral diverticulum 10.4 WT1 PAX8
7 peritoneum cancer 10.4 WT1 PAX8
8 clear cell hidradenoma 10.4 PAX8 MME
9 clear cell acanthoma 10.4 GATA3 FGFR2
10 prostatic acinar adenocarcinoma 10.4 WT1 PAX8
11 giant congenital nevus 10.3 NRAS HRAS
12 rete testis neoplasm 10.3 PAX8 MME
13 benign struma ovarii 10.3 NRAS HRAS
14 ovarian melanoma 10.3 NRAS HRAS
15 collecting duct carcinoma 10.3 PAX8 MME
16 malignant conjunctival melanoma 10.3 NRAS HRAS
17 congenital mesoblastic nephroma 10.3 WT1 NRAS
18 marcus gunn phenomenon 10.3 NRAS HRAS
19 malignant struma ovarii 10.3 NRAS HRAS
20 nodular malignant melanoma 10.3 NRAS HRAS
21 fetal adenoma 10.3 NRAS HRAS
22 meningeal melanomatosis 10.3 NRAS HRAS
23 melanocytic nevus syndrome, congenital 10.3 NRAS HRAS
24 cystic nephroma 10.3 WT1 MME
25 adult fibrosarcoma 10.2 WT1 HRAS
26 vulvar melanoma 10.2 NRAS HRAS
27 dysgerminoma 10.2 WT1 FGFR2
28 meningeal melanocytoma 10.2 NRAS MME
29 dysgerminoma of ovary 10.2 WT1 FGFR2
30 malignant skin fibrous histiocytoma 10.2 NRAS HRAS
31 adenocarcinoma in situ 10.2 PAX8 KRAS
32 malignant dermis tumor 10.2 NRAS HRAS
33 sigmoid neoplasm 10.1 KRAS HRAS
34 apocrine adenoma 10.1 KRAS HRAS
35 ras-associated autoimmune leukoproliferative disorder 10.1 NRAS KRAS
36 paronychia 10.1 KRAS HRAS
37 periampullary adenoma 10.1 KRAS HRAS
38 pancreatic mucinous cystadenoma 10.1 MME HRAS
39 endocervical carcinoma 10.1 PAX8 ESR1
40 bile duct cysts 10.1 KRAS HRAS
41 aggressive digital papillary adenocarcinoma 10.1 KRAS HRAS
42 appendix disease 10.1 KRAS HRAS
43 nasal cavity adenocarcinoma 10.1 KRAS HRAS
44 lung adenoid cystic carcinoma 10.1 KRAS HRAS
45 rare tumor 10.1
46 anal canal adenocarcinoma 10.1 KRAS HRAS
47 secondary hypertrophic osteoarthropathy 10.1 KRAS HRAS
48 central nervous system melanocytic neoplasm 10.1 NRAS HRAS
49 mixed cell type cancer 10.1 MME HRAS
50 biliary papillomatosis 10.1 KRAS HRAS

Graphical network of the top 20 diseases related to Wolffian Duct Adenocarcinoma:



Diseases related to Wolffian Duct Adenocarcinoma

Symptoms & Phenotypes for Wolffian Duct Adenocarcinoma

GenomeRNAi Phenotypes related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.93 HRAS KRAS
2 Decreased viability GR00106-A-0 9.93 KRAS
3 Decreased viability GR00221-A-1 9.93 ESR1 HRAS KRAS NRAS
4 Decreased viability GR00221-A-2 9.93 ESR1 HRAS KRAS
5 Decreased viability GR00221-A-3 9.93 HRAS NRAS
6 Decreased viability GR00221-A-4 9.93 ESR1
7 Decreased viability GR00301-A 9.93 KRAS
8 Decreased viability GR00381-A-1 9.93 KRAS
9 Decreased viability GR00402-S-2 9.93 ESR1 HRAS KRAS NRAS
10 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 GATA3 KRAS MME PAX8

MGI Mouse Phenotypes related to Wolffian Duct Adenocarcinoma:

46 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 ESR1 FGFR2 GATA3 HRAS KRAS NRAS
2 homeostasis/metabolism MP:0005376 10.2 ESR1 FGFR2 GATA3 HRAS KRAS MME
3 endocrine/exocrine gland MP:0005379 10.17 ESR1 FGFR2 GATA3 HRAS KRAS NRAS
4 growth/size/body region MP:0005378 10.16 ESR1 FGFR2 GATA3 HRAS KRAS NRAS
5 cellular MP:0005384 10.14 ESR1 FGFR2 GATA3 KRAS NRAS PAX8
6 embryo MP:0005380 10.12 ESR1 FGFR2 GATA3 KRAS NRAS PAX8
7 immune system MP:0005387 10.08 ESR1 FGFR2 GATA3 KRAS MME NRAS
8 mortality/aging MP:0010768 10.08 ESR1 FGFR2 GATA3 HRAS KRAS NRAS
9 craniofacial MP:0005382 10.07 FGFR2 GATA3 HRAS KRAS NRAS PAX8
10 integument MP:0010771 10.07 ESR1 FGFR2 GATA3 HRAS KRAS MME
11 digestive/alimentary MP:0005381 10.06 ESR1 FGFR2 GATA3 HRAS KRAS NRAS
12 no phenotypic analysis MP:0003012 10.01 ESR1 FGFR2 GATA3 HRAS KRAS NRAS
13 liver/biliary system MP:0005370 9.97 ESR1 FGFR2 KRAS MME NRAS WT1
14 normal MP:0002873 9.97 ESR1 FGFR2 GATA3 HRAS KRAS NRAS
15 limbs/digits/tail MP:0005371 9.91 ESR1 FGFR2 KRAS NRAS PAX8
16 neoplasm MP:0002006 9.91 ESR1 FGFR2 HRAS KRAS NRAS WT1
17 muscle MP:0005369 9.85 ESR1 FGFR2 GATA3 KRAS WT1
18 renal/urinary system MP:0005367 9.8 ESR1 FGFR2 GATA3 HRAS KRAS PAX8
19 reproductive system MP:0005389 9.63 ESR1 FGFR2 GATA3 KRAS PAX8 WT1
20 pigmentation MP:0001186 9.62 FGFR2 GATA3 KRAS NRAS
21 respiratory system MP:0005388 9.35 ESR1 FGFR2 HRAS KRAS WT1
22 skeleton MP:0005390 9.17 ESR1 FGFR2 GATA3 HRAS KRAS NRAS

Drugs & Therapeutics for Wolffian Duct Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Wolffian Duct Adenocarcinoma

Genetic Tests for Wolffian Duct Adenocarcinoma

Anatomical Context for Wolffian Duct Adenocarcinoma

MalaCards organs/tissues related to Wolffian Duct Adenocarcinoma:

41
Ovary

Publications for Wolffian Duct Adenocarcinoma

Articles related to Wolffian Duct Adenocarcinoma:

# Title Authors PMID Year
1
Cervical Mesonephric Adenocarcinoma With Novel FGFR2 Mutation. 38
31335448 2019
2
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. 38
23651629 2013
3
Cytopathology of cervical mesonephric adenocarcinoma: a report of two cases. 38
22300170 2013
4
Mesonephric adenocarcinoma (endometrioid type) of endocervix with diffuse mesonephric hyperplasia involving cervical wall and myometrium: an unusual case report. 38
23924560 2013

Variations for Wolffian Duct Adenocarcinoma

Expression for Wolffian Duct Adenocarcinoma

Search GEO for disease gene expression data for Wolffian Duct Adenocarcinoma.

Pathways for Wolffian Duct Adenocarcinoma

Pathways related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.27 NRAS KRAS HRAS GATA3 FGFR2
2
Show member pathways
13.19 NRAS KRAS HRAS FGFR2 ESR1
3
Show member pathways
12.97 NRAS KRAS HRAS FGFR2
4
Show member pathways
12.96 NRAS KRAS HRAS FGFR2
5
Show member pathways
12.94 NRAS KRAS HRAS ESR1
6
Show member pathways
12.9 NRAS KRAS HRAS FGFR2
7
Show member pathways
12.8 NRAS KRAS HRAS FGFR2
8
Show member pathways
12.79 NRAS KRAS HRAS FGFR2
9
Show member pathways
12.76 PAX8 NRAS KRAS HRAS FGFR2
10
Show member pathways
12.75 NRAS KRAS HRAS ESR1
11 12.7 NRAS KRAS HRAS FGFR2
12
Show member pathways
12.67 NRAS KRAS HRAS FGFR2
13
Show member pathways
12.66 NRAS KRAS HRAS FGFR2
14
Show member pathways
12.64 NRAS KRAS HRAS ESR1
15
Show member pathways
12.64 NRAS KRAS HRAS FGFR2 ESR1
16
Show member pathways
12.59 NRAS KRAS HRAS GATA3
17
Show member pathways
12.58 NRAS KRAS HRAS FGFR2 ESR1
18 12.56 NRAS KRAS HRAS FGFR2
19 12.52 PAX8 NRAS KRAS HRAS FGFR2 ESR1
20
Show member pathways
12.51 NRAS KRAS HRAS FGFR2
21
Show member pathways
12.47 NRAS KRAS HRAS GATA3
22
Show member pathways
12.44 NRAS KRAS HRAS FGFR2
23
Show member pathways
12.42 NRAS KRAS HRAS ESR1
24
Show member pathways
12.4 NRAS KRAS HRAS
25
Show member pathways
12.37 NRAS KRAS HRAS FGFR2
26
Show member pathways
12.36 NRAS KRAS HRAS
27
Show member pathways
12.36 NRAS KRAS HRAS FGFR2
28
Show member pathways
12.35 NRAS KRAS HRAS
29
Show member pathways
12.34 NRAS KRAS HRAS
30
Show member pathways
12.34 NRAS KRAS HRAS
31
Show member pathways
12.33 KRAS HRAS ESR1
32
Show member pathways
12.33 NRAS KRAS HRAS FGFR2
33 12.29 NRAS KRAS HRAS
34
Show member pathways
12.28 NRAS KRAS HRAS
35
Show member pathways
12.27 NRAS KRAS HRAS
36
Show member pathways
12.24 NRAS KRAS HRAS
37
Show member pathways
12.24 NRAS KRAS HRAS
38 12.24 NRAS KRAS HRAS
39 12.22 NRAS KRAS HRAS ESR1
40
Show member pathways
12.2 NRAS KRAS HRAS
41 12.19 NRAS KRAS HRAS
42
Show member pathways
12.19 NRAS KRAS HRAS FGFR2
43
Show member pathways
12.18 NRAS KRAS HRAS
44
Show member pathways
12.17 NRAS KRAS HRAS
45
Show member pathways
12.15 NRAS KRAS HRAS
46
Show member pathways
12.15 NRAS KRAS HRAS FGFR2
47
Show member pathways
12.14 NRAS KRAS HRAS
48
Show member pathways
12.13 NRAS KRAS HRAS
49 12.13 NRAS KRAS HRAS
50
Show member pathways
12.13 NRAS KRAS HRAS

GO Terms for Wolffian Duct Adenocarcinoma

Biological processes related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.93 WT1 PAX8 GATA3 ESR1
2 positive regulation of gene expression GO:0010628 9.88 WT1 KRAS HRAS GATA3
3 negative regulation of gene expression GO:0010629 9.82 HRAS GATA3 ESR1
4 positive regulation of protein kinase B signaling GO:0051897 9.79 GATA3 FGFR2 ESR1
5 male gonad development GO:0008584 9.74 WT1 GATA3 ESR1
6 positive regulation of transcription by RNA polymerase II GO:0045944 9.73 WT1 PAX8 HRAS GATA3 FGFR2 ESR1
7 ureteric bud development GO:0001657 9.65 WT1 FGFR2
8 Ras protein signal transduction GO:0007265 9.65 NRAS KRAS HRAS
9 embryonic organ development GO:0048568 9.64 GATA3 FGFR2
10 ventricular septum development GO:0003281 9.64 PAX8 GATA3
11 transcription by RNA polymerase II GO:0006366 9.63 GATA3 ESR1
12 regulation of long-term neuronal synaptic plasticity GO:0048169 9.62 KRAS HRAS
13 MAPK cascade GO:0000165 9.62 NRAS KRAS HRAS FGFR2
14 uterus development GO:0060065 9.61 GATA3 ESR1
15 positive regulation of phospholipase C activity GO:0010863 9.6 HRAS ESR1
16 mesonephros development GO:0001823 9.59 PAX8 GATA3
17 animal organ morphogenesis GO:0009887 9.58 HRAS FGFR2
18 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.58 NRAS KRAS HRAS
19 mesenchymal to epithelial transition GO:0060231 9.56 WT1 GATA3
20 cellular response to gonadotropin stimulus GO:0071371 9.55 WT1 PAX8
21 response to isolation stress GO:0035900 9.54 KRAS HRAS
22 inner ear morphogenesis GO:0042472 9.54 PAX8 GATA3 FGFR2
23 otic vesicle development GO:0071599 9.51 PAX8 GATA3
24 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 9.49 FGFR2 ESR1
25 metanephric S-shaped body morphogenesis GO:0072284 9.46 WT1 PAX8
26 metanephric epithelium development GO:0072207 9.43 WT1 PAX8
27 tissue development GO:0009888 9.32 WT1
28 regulation of branching involved in prostate gland morphogenesis GO:0060687 9.22 ESR1
29 prostate epithelial cord elongation GO:0060523 9.16 FGFR2 ESR1
30 positive regulation of thyroid hormone generation GO:2000611 8.96 PAX8 GATA3
31 kidney development GO:0001822 8.92 WT1 PAX8 MME GATA3

Molecular functions related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region DNA binding GO:0044212 9.33 WT1 PAX8 GATA3
2 sequence-specific DNA binding GO:0043565 9.26 WT1 PAX8 GATA3 ESR1
3 nucleotide binding GO:0000166 8.92 NRAS KRAS HRAS FGFR2

Sources for Wolffian Duct Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....