MCID: WLF006
MIFTS: 34

Wolffian Duct Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Wolffian Duct Adenocarcinoma

MalaCards integrated aliases for Wolffian Duct Adenocarcinoma:

Name: Wolffian Duct Adenocarcinoma 12 15
Cervical Mesonephric Adenocarcinoma 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5368
NCIt 49 C40254
UMLS 71 C1516419

Summaries for Wolffian Duct Adenocarcinoma

Disease Ontology : 12 A cervical adenocarcinoma that has material basis in remnants of mesonephric ducts and is located anywhere along the length between the ovary and vagina in sites of remnant wolffian ducts.

MalaCards based summary : Wolffian Duct Adenocarcinoma, also known as cervical mesonephric adenocarcinoma, is related to adenocarcinoma and pacinian tumor. An important gene associated with Wolffian Duct Adenocarcinoma is MME (Membrane Metalloendopeptidase), and among its related pathways/superpathways are MAPK signaling pathway and Downstream signaling events of B Cell Receptor (BCR). Affiliated tissues include breast, ovary and thyroid, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Wolffian Duct Adenocarcinoma

Diseases related to Wolffian Duct Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 364)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 28.7 TP53 KRT7 KRAS HRAS FGFR2
2 pacinian tumor 10.5 MME CALB2
3 fallopian tube adenocarcinoma 10.5 MME CALB2
4 rete testis adenoma 10.5 PAX8 CALB2
5 hidradenoma 10.4 MME KRT7
6 nephrogenic adenoma 10.4 PAX8 KRT7
7 peritoneal serous adenocarcinoma 10.4 WT1 CALB2
8 malignant epithelial mesothelioma 10.4 WT1 CALB2
9 testicular granulosa cell tumor 10.4 WT1 CALB2
10 prostatic acinar adenocarcinoma 10.4 PAX8 AR
11 luteoma 10.4 FGFR2 CALB2
12 subareolar duct papillomatosis 10.4 MME KRT7
13 nipple neoplasm 10.4 MME KRT7
14 testicular fibroma 10.4 WT1 CALB2
15 malignant biphasic mesothelioma 10.4 WT1 CALB2
16 mixed epithelial stromal tumour 10.4 MME KRT7
17 female urethral cancer 10.4 MME KRT7
18 cervical adenoma malignum 10.3 MME KRT7
19 clear cell papillary renal cell carcinoma 10.3 MME KRT7
20 chromophil adenoma of the kidney 10.3 MME KRT7
21 eccrine papillary adenocarcinoma 10.3 MME KRT7
22 mediastinum sarcoma 10.3 KRT7 CALB2
23 mucinous ovarian cystadenoma 10.3 KRT7 CALB2
24 renal pelvis adenocarcinoma 10.3 PAX8 KRT7
25 juvenile type testicular granulosa cell tumor 10.3 WT1 CALB2
26 breast myofibroblastoma 10.3 MME ESR1
27 clear cell cystadenofibroma 10.3 TP53 CALB2
28 urethral diverticulum 10.3 PAX8 KRT7
29 inverted transitional papilloma 10.3 KRT7 GATA3
30 ovarian germ cell teratoma 10.3 KRT7 CALB2
31 eccrine sweat gland neoplasm 10.3 MME KRT7
32 balloon cell malignant melanoma 10.3 MME KRT7
33 bartholin's gland adenocarcinoma 10.3 KRT7 GATA3
34 pancreatic mucinous cystadenoma 10.3 MME KRT7
35 breast leiomyoma 10.3 MME ESR1
36 mucinous stomach adenocarcinoma 10.3 KRT7 CALB2
37 pulmonary artery leiomyosarcoma 10.3 MME KRT7
38 fallopian tube endometrioid adenocarcinoma 10.3 PAX8 MME CALB2
39 mucinous tubular and spindle renal cell carcinoma 10.3 MME KRT7
40 adult type testicular granulosa cell tumor 10.3 ESR1 CALB2
41 bladder lateral wall cancer 10.3 MME KRT7
42 intravenous leiomyomatosis 10.3 MME ESR1
43 cutaneous adenocystic carcinoma 10.3 MME KRT7
44 rare head and neck tumor 10.3 TP53 FGFR2
45 benign peritoneal mesothelioma 10.3 KRT7 CALB2
46 liver leiomyoma 10.3 ESR1 CALB2
47 thyroid angiosarcoma 10.3 PAX8 KRT7
48 familial ovarian cancer 10.3 FGFR2 ESR1
49 vaginal endometrial stromal sarcoma 10.3 MME ESR1
50 vulvar apocrine adenocarcinoma 10.3 KRT7 AR

Graphical network of the top 20 diseases related to Wolffian Duct Adenocarcinoma:



Diseases related to Wolffian Duct Adenocarcinoma

Symptoms & Phenotypes for Wolffian Duct Adenocarcinoma

MGI Mouse Phenotypes related to Wolffian Duct Adenocarcinoma:

45 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.3 AR ESR1 FGFR2 GATA3 KRAS KRT7
2 homeostasis/metabolism MP:0005376 10.28 AR ESR1 FGFR2 GATA3 HRAS KRAS
3 behavior/neurological MP:0005386 10.26 AR CALB2 ESR1 FGFR2 HRAS KRAS
4 cardiovascular system MP:0005385 10.26 AR ESR1 FGFR2 GATA3 HRAS KRAS
5 endocrine/exocrine gland MP:0005379 10.22 AR ESR1 FGFR2 GATA3 HRAS KRAS
6 growth/size/body region MP:0005378 10.21 AR ESR1 FGFR2 GATA3 HRAS KRAS
7 embryo MP:0005380 10.18 AR ESR1 FGFR2 GATA3 KRAS PAX8
8 craniofacial MP:0005382 10.14 AR FGFR2 GATA3 HRAS KRAS PAX8
9 digestive/alimentary MP:0005381 10.13 AR ESR1 FGFR2 GATA3 HRAS KRAS
10 integument MP:0010771 10.13 AR ESR1 FGFR2 GATA3 HRAS KRAS
11 nervous system MP:0003631 10.13 AR CALB2 ESR1 FGFR2 GATA3 HRAS
12 normal MP:0002873 10.07 AR CALB2 ESR1 FGFR2 GATA3 HRAS
13 liver/biliary system MP:0005370 10.04 AR ESR1 FGFR2 KRAS MME TP53
14 muscle MP:0005369 10.02 AR ESR1 FGFR2 GATA3 KRAS TP53
15 no phenotypic analysis MP:0003012 10.01 ESR1 FGFR2 GATA3 HRAS KRAS PAX8
16 neoplasm MP:0002006 10 AR ESR1 FGFR2 HRAS KRAS TP53
17 limbs/digits/tail MP:0005371 9.99 AR ESR1 FGFR2 KRAS PAX8 TP53
18 renal/urinary system MP:0005367 9.96 AR ESR1 FGFR2 GATA3 HRAS KRAS
19 hearing/vestibular/ear MP:0005377 9.95 FGFR2 GATA3 KRAS PAX8 TP53
20 reproductive system MP:0005389 9.76 AR ESR1 FGFR2 GATA3 KRAS PAX8
21 pigmentation MP:0001186 9.72 AR FGFR2 GATA3 KRAS TP53
22 respiratory system MP:0005388 9.43 ESR1 FGFR2 HRAS KRAS TP53 WT1
23 skeleton MP:0005390 9.23 AR ESR1 FGFR2 GATA3 HRAS KRAS

Drugs & Therapeutics for Wolffian Duct Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Wolffian Duct Adenocarcinoma

Genetic Tests for Wolffian Duct Adenocarcinoma

Anatomical Context for Wolffian Duct Adenocarcinoma

MalaCards organs/tissues related to Wolffian Duct Adenocarcinoma:

40
Breast, Ovary, Thyroid, Lung, Colon, Myeloid, Kidney

Publications for Wolffian Duct Adenocarcinoma

Articles related to Wolffian Duct Adenocarcinoma:

# Title Authors PMID Year
1
Cervical Mesonephric Adenocarcinoma With Novel FGFR2 Mutation. 61
31335448 2019
2
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. 61
23651629 2013
3
Cytopathology of cervical mesonephric adenocarcinoma: a report of two cases. 61
22300170 2013
4
Mesonephric adenocarcinoma (endometrioid type) of endocervix with diffuse mesonephric hyperplasia involving cervical wall and myometrium: an unusual case report. 61
23924560 2013

Variations for Wolffian Duct Adenocarcinoma

Expression for Wolffian Duct Adenocarcinoma

Search GEO for disease gene expression data for Wolffian Duct Adenocarcinoma.

Pathways for Wolffian Duct Adenocarcinoma

Pathways related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1 12.63 TP53 KRAS HRAS FGFR2
2
Show member pathways
12.58 TP53 KRAS HRAS FGFR2
3
Show member pathways
12.56 TP53 KRAS HRAS ESR1
4
Show member pathways
12.52 TP53 KRAS HRAS FGFR2 ESR1
5
Show member pathways
12.46 TP53 KRAS HRAS FGFR2
6
Show member pathways
12.38 TP53 PAX8 KRAS HRAS FGFR2 AR
7
Show member pathways
12.36 TP53 KRAS HRAS FGFR2 ESR1
8
Show member pathways
12.32 TP53 KRAS HRAS FGFR2
9
Show member pathways
12.26 TP53 KRAS HRAS FGFR2
10 12.11 TP53 KRAS HRAS ESR1
11
Show member pathways
12.08 TP53 KRAS HRAS
12 12.05 TP53 KRAS HRAS
13
Show member pathways
12.05 TP53 KRAS HRAS FGFR2
14
Show member pathways
12.04 KRAS HRAS FGFR2
15
Show member pathways
12.02 TP53 KRAS HRAS
16
Show member pathways
12.01 TP53 KRAS HRAS
17 11.96 KRAS HRAS FGFR2
18
Show member pathways
11.93 TP53 KRAS HRAS
19 11.89 TP53 KRAS ESR1 AR
20 11.89 TP53 PAX8 KRAS HRAS FGFR2 ESR1
21 11.87 TP53 KRAS HRAS
22 11.85 TP53 KRAS HRAS
23 11.82 TP53 KRAS HRAS
24
Show member pathways
11.79 KRAS HRAS ESR1
25 11.73 KRAS ESR1 AR
26 11.7 TP53 KRAS HRAS ESR1
27 11.61 GATA3 ESR1 AR
28 11.56 TP53 KRAS HRAS
29 11.5 TP53 KRAS HRAS
30 11.33 KRAS HRAS ESR1
31 11.24 KRAS HRAS FGFR2
32 11.1 TP53 KRAS HRAS FGFR2
33 11.01 KRAS HRAS
34 10.94 KRAS HRAS
35 10.88 HRAS AR
36 10.79 KRAS HRAS ESR1
37 10.71 KRAS HRAS

GO Terms for Wolffian Duct Adenocarcinoma

Cellular components related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 9.02 TP53 PAX8 GATA3 ESR1 AR

Biological processes related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.14 WT1 TP53 PAX8 GATA3 ESR1 AR
2 regulation of transcription by RNA polymerase II GO:0006357 10.05 WT1 TP53 GATA3 ESR1 AR
3 negative regulation of transcription by RNA polymerase II GO:0000122 9.93 WT1 TP53 GATA3 FGFR2 ESR1 AR
4 negative regulation of gene expression GO:0010629 9.89 TP53 HRAS GATA3 ESR1
5 protein deubiquitination GO:0016579 9.88 TP53 GATA3 ESR1 AR
6 negative regulation of cell proliferation GO:0008285 9.88 WT1 TP53 HRAS GATA3 AR
7 transcription, DNA-templated GO:0006351 9.83 PAX8 ESR1 AR
8 in utero embryonic development GO:0001701 9.83 TP53 GATA3 FGFR2 AR
9 response to ethanol GO:0045471 9.82 TP53 GATA3 FGFR2
10 positive regulation of MAPK cascade GO:0043410 9.82 HRAS FGFR2 AR
11 Ras protein signal transduction GO:0007265 9.75 TP53 KRAS HRAS
12 positive regulation of transcription, DNA-templated GO:0045893 9.73 WT1 TP53 PAX8 GATA3 ESR1 AR
13 inner ear morphogenesis GO:0042472 9.71 PAX8 GATA3 FGFR2
14 regulation of long-term neuronal synaptic plasticity GO:0048169 9.67 KRAS HRAS
15 uterus development GO:0060065 9.66 GATA3 ESR1
16 mammary gland alveolus development GO:0060749 9.66 ESR1 AR
17 replicative senescence GO:0090399 9.64 TP53 MME
18 positive regulation of phospholipase C activity GO:0010863 9.63 HRAS ESR1
19 mesonephros development GO:0001823 9.63 PAX8 GATA3
20 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.62 TP53 ESR1
21 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.62 TP53 ESR1
22 kidney development GO:0001822 9.62 WT1 PAX8 MME GATA3
23 mesenchymal to epithelial transition GO:0060231 9.61 WT1 GATA3
24 cellular response to gonadotropin stimulus GO:0071371 9.61 WT1 PAX8
25 reproductive structure development GO:0048608 9.6 FGFR2 AR
26 otic vesicle development GO:0071599 9.57 PAX8 GATA3
27 response to isolation stress GO:0035900 9.56 KRAS HRAS
28 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 9.55 FGFR2 ESR1
29 embryonic organ development GO:0048568 9.54 TP53 GATA3 FGFR2
30 metanephric S-shaped body morphogenesis GO:0072284 9.51 WT1 PAX8
31 metanephric epithelium development GO:0072207 9.49 WT1 PAX8
32 male gonad development GO:0008584 9.46 WT1 GATA3 ESR1 AR
33 positive regulation of thyroid hormone generation GO:2000611 9.43 PAX8 GATA3
34 positive regulation of gene expression GO:0010628 9.43 WT1 TP53 KRAS HRAS GATA3 AR
35 prostate epithelial cord elongation GO:0060523 9.4 FGFR2 ESR1
36 positive regulation of transcription by RNA polymerase II GO:0045944 9.23 WT1 TP53 PAX8 HRAS GATA3 FGFR2

Molecular functions related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.85 WT1 TP53 PAX8 GATA3 ESR1 AR
2 sequence-specific DNA binding GO:0043565 9.8 WT1 PAX8 GATA3 ESR1 AR
3 transcription factor binding GO:0008134 9.73 TP53 GATA3 ESR1 AR
4 DNA-binding transcription factor activity GO:0003700 9.73 WT1 TP53 PAX8 GATA3 ESR1 AR
5 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.72 TP53 PAX8 GATA3 ESR1 AR
6 zinc ion binding GO:0008270 9.63 WT1 TP53 MME GATA3 ESR1 AR
7 transcription regulatory region DNA binding GO:0044212 9.35 WT1 TP53 PAX8 GATA3 AR
8 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.1 WT1 TP53 PAX8 GATA3 ESR1 AR

Sources for Wolffian Duct Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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