MCID: WLF006
MIFTS: 32

Wolffian Duct Adenocarcinoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Wolffian Duct Adenocarcinoma

MalaCards integrated aliases for Wolffian Duct Adenocarcinoma:

Name: Wolffian Duct Adenocarcinoma 12 15
Cervical Mesonephric Adenocarcinoma 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5368
NCIt 49 C40254
UMLS 71 C1516419

Summaries for Wolffian Duct Adenocarcinoma

Disease Ontology : 12 A cervical adenocarcinoma that has material basis in remnants of mesonephric ducts and is located anywhere along the length between the ovary and vagina in sites of remnant wolffian ducts.

MalaCards based summary : Wolffian Duct Adenocarcinoma, also known as cervical mesonephric adenocarcinoma, is related to adenocarcinoma and fallopian tube adenocarcinoma. An important gene associated with Wolffian Duct Adenocarcinoma is CALB2 (Calbindin 2), and among its related pathways/superpathways are MAPK signaling pathway and Downstream signaling events of B Cell Receptor (BCR). Affiliated tissues include ovary, and related phenotypes are cellular and homeostasis/metabolism

Related Diseases for Wolffian Duct Adenocarcinoma

Diseases related to Wolffian Duct Adenocarcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 381)
# Related Disease Score Top Affiliating Genes
1 adenocarcinoma 28.8 TP53 KRT7 KRAS HRAS FGFR2
2 fallopian tube adenocarcinoma 10.5 MME CALB2
3 pacinian tumor 10.5 MME CALB2
4 rete testis adenoma 10.5 PAX8 CALB2
5 bladder benign neoplasm 10.4 PAX8 KRT7
6 nephrogenic adenoma 10.4 PAX8 KRT7
7 testicular granulosa cell tumor 10.4 WT1 CALB2
8 testicular fibroma 10.4 WT1 CALB2
9 subareolar duct papillomatosis 10.4 MME KRT7
10 nipple benign neoplasm 10.4 MME KRT7
11 luteoma 10.4 FGFR2 CALB2
12 pancreatic serous cystadenocarcinoma 10.4 MME KRT7
13 mixed epithelial stromal tumour 10.4 MME KRT7
14 colon leiomyosarcoma 10.4 WT1 PAX8
15 seminal vesicle adenocarcinoma 10.4 PAX8 KRT7
16 female urethral cancer 10.4 MME KRT7
17 juvenile type testicular granulosa cell tumor 10.4 WT1 CALB2
18 ovarian gonadoblastoma 10.4 WT1 CALB2
19 clear cell papillary renal cell carcinoma 10.3 MME KRT7
20 renal pelvis adenocarcinoma 10.3 PAX8 KRT7
21 chromophil adenoma of the kidney 10.3 MME KRT7
22 inverted transitional papilloma 10.3 KRT7 GATA3
23 krukenberg carcinoma 10.3 PAX8 KRT7
24 bartholin's gland adenocarcinoma 10.3 KRT7 GATA3
25 pulmonary artery leiomyosarcoma 10.3 MME KRT7
26 urethral diverticulum 10.3 PAX8 KRT7
27 ovarian germ cell teratoma 10.3 KRT7 CALB2
28 clear cell cystadenofibroma 10.3 TP53 CALB2
29 balloon cell malignant melanoma 10.3 MME KRT7
30 pancreatic mucinous cystadenoma 10.3 MME KRT7
31 urinary bladder small cell neuroendocrine carcinoma 10.3 KRT7 GATA3
32 ureter small cell carcinoma 10.3 KRT7 GATA3
33 mucinous stomach adenocarcinoma 10.3 KRT7 CALB2
34 eccrine papillary adenocarcinoma 10.3 MME KRT7
35 cecum lymphoma 10.3 TP53 MME
36 epithelial predominant wilms' tumor 10.3 WT1 KRT7
37 cutaneous adenocystic carcinoma 10.3 MME KRT7
38 mucinous tubular and spindle renal cell carcinoma 10.3 MME KRT7
39 breast myofibroblastoma 10.3 MME ESR1
40 nephrogenic adenofibroma 10.3 WT1 KRT7
41 prostatic acinar adenocarcinoma 10.3 PAX8 AR
42 uterine corpus adenosarcoma 10.3 MME ESR1
43 bladder lateral wall cancer 10.3 MME KRT7
44 adult type testicular granulosa cell tumor 10.3 ESR1 CALB2
45 fallopian tube endometrioid adenocarcinoma 10.3 PAX8 MME CALB2
46 rare head and neck tumor 10.3 TP53 FGFR2
47 ovarian brenner tumor 10.3 WT1 KRT7
48 squamous papillomatosis 10.3 MME KRT7
49 intravenous leiomyomatosis 10.3 MME ESR1
50 familial ovarian cancer 10.3 FGFR2 ESR1

Graphical network of the top 20 diseases related to Wolffian Duct Adenocarcinoma:



Diseases related to Wolffian Duct Adenocarcinoma

Symptoms & Phenotypes for Wolffian Duct Adenocarcinoma

MGI Mouse Phenotypes related to Wolffian Duct Adenocarcinoma:

45 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.3 AR ESR1 FGFR2 GATA3 KRAS KRT7
2 homeostasis/metabolism MP:0005376 10.28 AR ESR1 FGFR2 GATA3 HRAS KRAS
3 behavior/neurological MP:0005386 10.26 AR CALB2 ESR1 FGFR2 HRAS KRAS
4 cardiovascular system MP:0005385 10.26 AR ESR1 FGFR2 GATA3 HRAS KRAS
5 endocrine/exocrine gland MP:0005379 10.22 AR ESR1 FGFR2 GATA3 HRAS KRAS
6 growth/size/body region MP:0005378 10.21 AR ESR1 FGFR2 GATA3 HRAS KRAS
7 embryo MP:0005380 10.18 AR ESR1 FGFR2 GATA3 KRAS PAX8
8 craniofacial MP:0005382 10.14 AR FGFR2 GATA3 HRAS KRAS PAX8
9 digestive/alimentary MP:0005381 10.13 AR ESR1 FGFR2 GATA3 HRAS KRAS
10 integument MP:0010771 10.13 AR ESR1 FGFR2 GATA3 HRAS KRAS
11 nervous system MP:0003631 10.13 AR CALB2 ESR1 FGFR2 GATA3 HRAS
12 normal MP:0002873 10.07 AR CALB2 ESR1 FGFR2 GATA3 HRAS
13 liver/biliary system MP:0005370 10.04 AR ESR1 FGFR2 KRAS MME TP53
14 muscle MP:0005369 10.02 AR ESR1 FGFR2 GATA3 KRAS TP53
15 no phenotypic analysis MP:0003012 10.01 ESR1 FGFR2 GATA3 HRAS KRAS PAX8
16 neoplasm MP:0002006 10 AR ESR1 FGFR2 HRAS KRAS TP53
17 limbs/digits/tail MP:0005371 9.99 AR ESR1 FGFR2 KRAS PAX8 TP53
18 renal/urinary system MP:0005367 9.96 AR ESR1 FGFR2 GATA3 HRAS KRAS
19 hearing/vestibular/ear MP:0005377 9.95 FGFR2 GATA3 KRAS PAX8 TP53
20 reproductive system MP:0005389 9.76 AR ESR1 FGFR2 GATA3 KRAS PAX8
21 pigmentation MP:0001186 9.72 AR FGFR2 GATA3 KRAS TP53
22 respiratory system MP:0005388 9.43 ESR1 FGFR2 HRAS KRAS TP53 WT1
23 skeleton MP:0005390 9.23 AR ESR1 FGFR2 GATA3 HRAS KRAS

Drugs & Therapeutics for Wolffian Duct Adenocarcinoma

Search Clinical Trials , NIH Clinical Center for Wolffian Duct Adenocarcinoma

Genetic Tests for Wolffian Duct Adenocarcinoma

Anatomical Context for Wolffian Duct Adenocarcinoma

MalaCards organs/tissues related to Wolffian Duct Adenocarcinoma:

40
Ovary

Publications for Wolffian Duct Adenocarcinoma

Articles related to Wolffian Duct Adenocarcinoma:

# Title Authors PMID Year
1
Cervical Mesonephric Adenocarcinoma With Novel FGFR2 Mutation. 61
31335448 2019
2
Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature. 61
23651629 2013
3
Cytopathology of cervical mesonephric adenocarcinoma: a report of two cases. 61
22300170 2013
4
Mesonephric adenocarcinoma (endometrioid type) of endocervix with diffuse mesonephric hyperplasia involving cervical wall and myometrium: an unusual case report. 61
23924560 2013

Variations for Wolffian Duct Adenocarcinoma

Expression for Wolffian Duct Adenocarcinoma

Search GEO for disease gene expression data for Wolffian Duct Adenocarcinoma.

Pathways for Wolffian Duct Adenocarcinoma

Pathways related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1 12.63 TP53 KRAS HRAS FGFR2
2
Show member pathways
12.58 TP53 KRAS HRAS FGFR2
3
Show member pathways
12.56 TP53 KRAS HRAS ESR1
4
Show member pathways
12.54 TP53 KRAS HRAS FGFR2 ESR1
5
Show member pathways
12.45 TP53 KRAS HRAS FGFR2
6
Show member pathways
12.4 TP53 KRAS HRAS FGFR2 ESR1
7
Show member pathways
12.38 TP53 PAX8 KRAS HRAS FGFR2 AR
8
Show member pathways
12.35 TP53 KRAS HRAS FGFR2
9
Show member pathways
12.33 TP53 KRAS HRAS FGFR2
10
Show member pathways
12.27 TP53 KRAS HRAS FGFR2
11 12.12 TP53 KRAS HRAS ESR1
12
Show member pathways
12.06 TP53 KRAS HRAS
13
Show member pathways
12.04 KRAS HRAS FGFR2
14 12.04 TP53 KRAS HRAS
15
Show member pathways
12.01 TP53 KRAS HRAS
16
Show member pathways
12.01 TP53 KRAS HRAS
17 11.97 KRAS HRAS FGFR2
18
Show member pathways
11.95 TP53 KRAS HRAS
19
Show member pathways
11.95 TP53 KRAS HRAS FGFR2 AR
20 11.92 TP53 KRAS ESR1 AR
21 11.89 TP53 PAX8 KRAS HRAS FGFR2 ESR1
22 11.87 TP53 KRAS HRAS
23 11.85 TP53 KRAS HRAS
24 11.83 TP53 KRAS HRAS
25
Show member pathways
11.8 KRAS HRAS ESR1
26 11.74 KRAS ESR1 AR
27 11.71 TP53 KRAS HRAS ESR1
28 11.62 GATA3 ESR1 AR
29 11.58 TP53 KRAS HRAS
30 11.53 TP53 KRAS HRAS
31 11.35 KRAS HRAS ESR1
32 11.27 KRAS HRAS FGFR2
33 11.1 TP53 KRAS HRAS FGFR2
34 11.01 KRAS HRAS
35 10.95 KRAS HRAS
36 10.89 HRAS AR
37 10.79 KRAS HRAS ESR1
38 10.73 KRAS HRAS

GO Terms for Wolffian Duct Adenocarcinoma

Cellular components related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.65 WT1 TP53 PAX8 KRT7 HRAS GATA3
2 nuclear chromatin GO:0000790 9.02 TP53 PAX8 GATA3 ESR1 AR

Biological processes related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.14 WT1 TP53 PAX8 GATA3 ESR1 AR
2 regulation of transcription by RNA polymerase II GO:0006357 10.06 WT1 TP53 GATA3 ESR1 AR
3 negative regulation of gene expression GO:0010629 9.92 TP53 HRAS GATA3 ESR1
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.91 WT1 TP53 GATA3 FGFR2 ESR1 AR
5 protein deubiquitination GO:0016579 9.88 TP53 GATA3 ESR1 AR
6 negative regulation of cell proliferation GO:0008285 9.88 WT1 TP53 HRAS GATA3 AR
7 in utero embryonic development GO:0001701 9.84 TP53 GATA3 FGFR2 AR
8 transcription, DNA-templated GO:0006351 9.83 PAX8 ESR1 AR
9 positive regulation of MAPK cascade GO:0043410 9.82 HRAS FGFR2 AR
10 Ras protein signal transduction GO:0007265 9.75 TP53 KRAS HRAS
11 positive regulation of transcription, DNA-templated GO:0045893 9.73 WT1 TP53 PAX8 GATA3 ESR1 AR
12 inner ear morphogenesis GO:0042472 9.72 PAX8 GATA3 FGFR2
13 regulation of long-term neuronal synaptic plasticity GO:0048169 9.67 KRAS HRAS
14 mammary gland alveolus development GO:0060749 9.66 ESR1 AR
15 uterus development GO:0060065 9.65 GATA3 ESR1
16 replicative senescence GO:0090399 9.64 TP53 MME
17 positive regulation of phospholipase C activity GO:0010863 9.64 HRAS ESR1
18 mesonephros development GO:0001823 9.63 PAX8 GATA3
19 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899 9.63 TP53 ESR1
20 embryonic organ development GO:0048568 9.63 TP53 GATA3 FGFR2
21 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.62 TP53 ESR1
22 kidney development GO:0001822 9.62 WT1 PAX8 MME GATA3
23 mesenchymal to epithelial transition GO:0060231 9.61 WT1 GATA3
24 otic vesicle development GO:0071599 9.61 PAX8 GATA3
25 cellular response to gonadotropin stimulus GO:0071371 9.6 WT1 PAX8
26 reproductive structure development GO:0048608 9.59 FGFR2 AR
27 response to isolation stress GO:0035900 9.57 KRAS HRAS
28 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 9.56 FGFR2 ESR1
29 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.54 WT1 TP53 GATA3
30 metanephric S-shaped body morphogenesis GO:0072284 9.52 WT1 PAX8
31 metanephric epithelium development GO:0072207 9.51 WT1 PAX8
32 positive regulation of thyroid hormone generation GO:2000611 9.49 PAX8 GATA3
33 male gonad development GO:0008584 9.46 WT1 GATA3 ESR1 AR
34 positive regulation of gene expression GO:0010628 9.43 WT1 TP53 KRAS HRAS GATA3 AR
35 prostate epithelial cord elongation GO:0060523 9.4 FGFR2 ESR1
36 positive regulation of transcription by RNA polymerase II GO:0045944 9.23 WT1 TP53 PAX8 HRAS GATA3 FGFR2

Molecular functions related to Wolffian Duct Adenocarcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.85 WT1 TP53 PAX8 GATA3 ESR1 AR
2 sequence-specific DNA binding GO:0043565 9.83 WT1 PAX8 GATA3 ESR1 AR
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.8 TP53 PAX8 GATA3 ESR1 AR
4 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.8 WT1 TP53 PAX8 GATA3 ESR1 AR
5 transcription factor binding GO:0008134 9.76 TP53 GATA3 ESR1 AR
6 zinc ion binding GO:0008270 9.73 WT1 TP53 MME GATA3 ESR1 AR
7 transcription regulatory region sequence-specific DNA binding GO:0000976 9.55 WT1 TP53 PAX8 GATA3 AR
8 transcription regulatory region DNA binding GO:0044212 9.35 WT1 TP53 PAX8 GATA3 AR
9 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.1 WT1 TP53 PAX8 GATA3 ESR1 AR

Sources for Wolffian Duct Adenocarcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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