WAT
MCID: WLF003
MIFTS: 26

Wolffian Duct Adenoma (WAT)

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Wolffian Duct Adenoma

MalaCards integrated aliases for Wolffian Duct Adenoma:

Name: Wolffian Duct Adenoma 12 52 15
Mesonephroma, Benign 12 71
Benign Mesonephroma 12 52
Mesonephric Adenoma 12 52
Female Adnexal Tumor of Probable Wolffian Origin 52
Wolffian Adnexal Tumor 52
Wolffian Adenoma 52
Wolffian Tumor 52
Fatwo 52
Wat 52

Classifications:



External Ids:

Disease Ontology 12 DOID:2616
NCIt 49 C4294
SNOMED-CT 67 72889001
UMLS 71 C0334530

Summaries for Wolffian Duct Adenoma

NIH Rare Diseases : 52 Benign mesonephroma (Wolffian tumors or Wolffian duct adenomas) are rare tumors located anywhere along the length between the ovary and vagina in sites of remnant wolffian ducts. Wolffian ducts are structures in a developing embryo that get incorporated into the reproductive system in males and degenerate in females. Wolffian tumors are thought to have a low potential to become cancerous and tend to range from 0.8 to 25 centimeters in size. Surgery is the recommended treatment. In a small number of cases, recurrences or malignancy have been been reported. Close follow-up is advised.

MalaCards based summary : Wolffian Duct Adenoma, also known as mesonephroma, benign, is related to wolffian adnexal neoplasm and rare tumor. An important gene associated with Wolffian Duct Adenoma is PAX2 (Paired Box 2), and among its related pathways/superpathways are Primary Focal Segmental Glomerulosclerosis FSGS and ID signaling pathway. Affiliated tissues include region of the wolffian duct and ovary.

Disease Ontology : 12 A reproductive organ benign neoplasm that derives from glandular epithelial cells and that is located in the region of the Wolffian duct.

Related Diseases for Wolffian Duct Adenoma

Diseases related to Wolffian Duct Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 wolffian adnexal neoplasm 11.8
2 rare tumor 10.3
3 lymphoma, hodgkin, classic 10.3
4 scott syndrome 10.3
5 lymphoma, non-hodgkin, familial 10.3
6 diffuse large b-cell lymphoma 10.3
7 adenocarcinoma 10.3
8 sertoli cell tumor 10.3
9 endometrioid ovary carcinoma 10.3
10 posttransplant acute limbic encephalitis 10.3
11 body mass index quantitative trait locus 11 10.2
12 body mass index quantitative trait locus 9 10.2
13 body mass index quantitative trait locus 8 10.2
14 body mass index quantitative trait locus 4 10.2
15 body mass index quantitative trait locus 10 10.2
16 body mass index quantitative trait locus 7 10.2
17 body mass index quantitative trait locus 12 10.2
18 body mass index quantitative trait locus 14 10.2
19 barrett esophagus 10.2
20 body mass index quantitative trait locus 18 10.2
21 body mass index quantitative trait locus 19 10.2
22 body mass index quantitative trait locus 20 10.2
23 hyperinsulinism 10.2
24 diabetes mellitus 10.2
25 rete testis adenoma 10.1 PAX8 PAX2
26 leiomyoma, uterine 10.1
27 peutz-jeghers syndrome 10.1
28 leiomyoma 10.1
29 sex cord-gonadal stromal tumor 10.1
30 leydig cell tumor 10.1
31 sertoli-leydig cell tumor 10.1
32 b-cell lymphoma 10.1
33 adenomatoid tumor 10.1
34 male urethral cancer 10.1 KLK3 AMACR
35 ureterocele 10.1 PAX8 PAX2
36 urethra clear cell adenocarcinoma 10.1 KLK3 AMACR
37 urethra adenocarcinoma 10.1 KLK3 AMACR
38 adenosquamous prostate carcinoma 10.1 KLK3 AMACR
39 urethra cancer 10.1 KLK3 AMACR
40 prostate transitional cell carcinoma 10.1 KLK3 AMACR
41 wilms tumor 5 10.1 PAX8 PAX2
42 hypothyroidism, congenital, nongoitrous, 2 10.1 PAX8 PAX2
43 papillorenal syndrome 10.1 PAX8 PAX2
44 adenoma 10.0
45 epithelial predominant wilms' tumor 10.0 KRT7 AMACR
46 alcohol dependence 10.0
47 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
48 arts syndrome 10.0
49 allergic rhinitis 10.0
50 fatty liver disease, nonalcoholic 1 10.0

Graphical network of the top 20 diseases related to Wolffian Duct Adenoma:



Diseases related to Wolffian Duct Adenoma

Symptoms & Phenotypes for Wolffian Duct Adenoma

Drugs & Therapeutics for Wolffian Duct Adenoma

Search Clinical Trials , NIH Clinical Center for Wolffian Duct Adenoma

Genetic Tests for Wolffian Duct Adenoma

Anatomical Context for Wolffian Duct Adenoma

The Foundational Model of Anatomy Ontology organs/tissues related to Wolffian Duct Adenoma:

19
Region Of The Wolffian Duct

MalaCards organs/tissues related to Wolffian Duct Adenoma:

40
Ovary

Publications for Wolffian Duct Adenoma

Articles related to Wolffian Duct Adenoma:

# Title Authors PMID Year
1
Mesonephric adenoma in remnant ureteric stump: A rare entity. 61
21716880 2011
2
Nephrogenic metaplasia of urinary bladder--a case report. 61
16295498 2004

Variations for Wolffian Duct Adenoma

Expression for Wolffian Duct Adenoma

Search GEO for disease gene expression data for Wolffian Duct Adenoma.

Pathways for Wolffian Duct Adenoma

Pathways related to Wolffian Duct Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 PAX2 MME
2 9.83 PAX8 PAX2

GO Terms for Wolffian Duct Adenoma

Biological processes related to Wolffian Duct Adenoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 inner ear morphogenesis GO:0042472 9.58 PAX8 PAX2
2 branching involved in ureteric bud morphogenesis GO:0001658 9.57 PAX8 PAX2
3 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.56 PAX8 PAX2
4 urogenital system development GO:0001655 9.55 PAX8 PAX2
5 mesonephros development GO:0001823 9.54 PAX8 PAX2
6 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.52 PAX8 PAX2
7 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.51 PAX8 PAX2
8 pronephros development GO:0048793 9.49 PAX8 PAX2
9 metanephric epithelium development GO:0072207 9.48 PAX8 PAX2
10 metanephric nephron tubule formation GO:0072289 9.46 PAX8 PAX2
11 metanephric distal convoluted tubule development GO:0072221 9.43 PAX8 PAX2
12 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.4 PAX8 PAX2
13 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.37 PAX8 PAX2
14 positive regulation of metanephric DCT cell differentiation GO:2000594 9.32 PAX8 PAX2
15 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.26 PAX8 PAX2
16 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.16 PAX8 PAX2
17 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 8.96 PAX8 PAX2
18 pronephric field specification GO:0039003 8.62 PAX8 PAX2

Molecular functions related to Wolffian Duct Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 8.62 MME KLK3

Sources for Wolffian Duct Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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