MCID: WLF013
MIFTS: 51

Wolfram Syndrome 1

Categories: Genetic diseases, Eye diseases, Ear diseases, Endocrine diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Wolfram Syndrome 1

MalaCards integrated aliases for Wolfram Syndrome 1:

Name: Wolfram Syndrome 1 57 12 75 15
Wfs1 57 12 75
Didmoad 57 75
Wfs 57 75
Diabetes Insipidus and Mellitus with Optic Atrophy and Deafness; Didmoad 57
Diabetes Insipidus and Mellitus with Optic Atrophy and Deafness Syndrome 75
Diabetes Insipidus and Mellitus with Optic Atrophy and Deafness 57
Wolfram Syndrome 73

Characteristics:

OMIM:

57
Inheritance:
autosomal recessive


HPO:

32
wolfram syndrome 1:
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Wolfram Syndrome 1

OMIM : 57 Wolfram syndrome-1 is a rare and severe autosomal recessive neurodegenerative disease characterized by diabetes mellitus, optic atrophy, diabetes insipidus, and deafness (DIDMOAD). Additional clinical features may include renal abnormalities, ataxia, dementia or mental retardation, and diverse psychiatric illnesses. The minimal diagnostic criteria for Wolfram syndrome are optic atrophy and diabetes mellitus of juvenile onset. Hearing impairment in Wolfram syndrome is typically progressive and mainly affects the higher frequencies, but a small fraction of affected individuals have congenital deafness (summary by Rendtorff et al., 2011). Autosomal dominant mutations in the WFS1 gene have been found to cause low-frequency nonsyndromic deafness (600965) as well as a Wolfram syndrome-like phenotype (614296) in which affected individuals have hearing impairment with diabetes mellitus and/or optic atrophy. (222300)

MalaCards based summary : Wolfram Syndrome 1, also known as wfs1, is related to diabetes insipidus and mood disorder, and has symptoms including ataxia, seizures and tremor. An important gene associated with Wolfram Syndrome 1 is WFS1 (Wolframin ER Transmembrane Glycoprotein), and among its related pathways/superpathways are Neuroscience and Unfolded Protein Response (UPR). The drugs Acetylcysteine and Deferiprone have been mentioned in the context of this disorder. Affiliated tissues include brain and pancreas, and related phenotypes are ptosis and nystagmus

UniProtKB/Swiss-Prot : 75 Wolfram syndrome 1: A rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. Other manifestations include diabetes insipidus, sensorineural deafness, dementia, psychiatric illnesses.

Disease Ontology : 12 An autosomal recessive disease that is characterized by diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders and has material basis in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the WFS1 gene on chromosome 4p16.1.

Related Diseases for Wolfram Syndrome 1

Graphical network of the top 20 diseases related to Wolfram Syndrome 1:



Diseases related to Wolfram Syndrome 1

Symptoms & Phenotypes for Wolfram Syndrome 1

Symptoms via clinical synopsis from OMIM:

57
Neurologic Central Nervous System:
brain atrophy
seizures
ataxia
dysarthria
tremor
more
Endocrine Features:
diabetes mellitus
hypothyroidism
diabetes insipidus

GenitourinaryInternal GenitaliaMale:
testicular atrophy

Genitourinary Ureters:
hydroureter

Growth Other:
growth retardation

Skeletal Hands:
limited mobility of proximal interphalangeal joint

Head And Neck Eyes:
ptosis
nystagmus
optic atrophy
pigmentary retinopathy

Cardiovascular Heart:
cardiomyopathy

Genitourinary Kidneys:
hydronephrosis

Genitourinary Bladder:
neurogenic bladder

Head And Neck Ears:
hearing loss, sensorineural


Clinical features from OMIM:

222300

Human phenotypes related to Wolfram Syndrome 1:

32 (show all 27)
# Description HPO Frequency HPO Source Accession
1 ptosis 32 HP:0000508
2 nystagmus 32 HP:0000639
3 diabetes mellitus 32 HP:0000819
4 hypothyroidism 32 HP:0000821
5 intellectual disability 32 HP:0001249
6 seizures 32 HP:0001250
7 ataxia 32 HP:0001251
8 dysarthria 32 HP:0001260
9 tremor 32 HP:0001337
10 dysphagia 32 HP:0002015
11 behavioral abnormality 32 HP:0000708
12 sensorineural hearing impairment 32 HP:0000407
13 optic atrophy 32 HP:0000648
14 growth delay 32 HP:0001510
15 cardiomyopathy 32 HP:0001638
16 thrombocytopenia 32 HP:0001873
17 stroke-like episode 32 HP:0002401
18 testicular atrophy 32 HP:0000029
19 diabetes insipidus 32 HP:0000873
20 hydronephrosis 32 HP:0000126
21 hydroureter 32 HP:0000072
22 cerebral atrophy 32 HP:0002059
23 neurogenic bladder 32 HP:0000011
24 pigmentary retinopathy 32 HP:0000580
25 megaloblastic anemia 32 HP:0001889
26 sideroblastic anemia 32 HP:0001924
27 limited mobility of proximal interphalangeal joint 32 HP:0006217

UMLS symptoms related to Wolfram Syndrome 1:


ataxia, seizures, tremor

MGI Mouse Phenotypes related to Wolfram Syndrome 1:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 ATF6 AVP COMT HSPA5 TH WFS1
2 mortality/aging MP:0010768 9.1 ATF6 AVP HSPA5 SYVN1 TH WFS1

Drugs & Therapeutics for Wolfram Syndrome 1

Drugs for Wolfram Syndrome 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcysteine Approved, Investigational Phase 2, Phase 3 616-91-1 12035
2
Deferiprone Approved Phase 2, Phase 3 30652-11-0 2972
3
Iron Approved Phase 2, Phase 3 7439-89-6 23925
4
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
5 Hormone Antagonists Phase 2, Phase 3,Not Applicable
6 Hormones Phase 2, Phase 3,Not Applicable
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3,Not Applicable
8 Hypoglycemic Agents Phase 2, Phase 3,Not Applicable
9 Incretins Phase 2, Phase 3,Not Applicable
10 Antidotes Phase 2, Phase 3
11 Anti-Infective Agents Phase 2, Phase 3
12 Antioxidants Phase 2, Phase 3
13 Antiviral Agents Phase 2, Phase 3
14 Chelating Agents Phase 2, Phase 3
15 Dipeptidyl-Peptidase IV Inhibitors Phase 2, Phase 3
16 Expectorants Phase 2, Phase 3
17 HIV Protease Inhibitors Phase 2, Phase 3
18 Iron Chelating Agents Phase 2, Phase 3
19 N-monoacetylcystine Phase 2, Phase 3
20
protease inhibitors Phase 2, Phase 3
21 Protective Agents Phase 2, Phase 3
22 Respiratory System Agents Phase 2, Phase 3
23 Sitagliptin Phosphate Phase 2, Phase 3
24
Dantrolene Approved, Investigational Phase 1, Phase 2 7261-97-4 2952 6914273
25 Neuromuscular Agents Phase 1, Phase 2
26 Peripheral Nervous System Agents Phase 1, Phase 2
27
Exenatide Approved, Investigational Not Applicable 141758-74-9 15991534
28
Coal tar Approved 8007-45-2
29 Glucagon-Like Peptide 1 Not Applicable
30 glucagon
31 insulin
32 Insulin, Globin Zinc

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy Not yet recruiting NCT02882477 Phase 2, Phase 3 Deferiprone;Acetylcysteine;Sitagliptin and Metformin
2 A Clinical Trial of Dantrolene Sodium in Pediatric and Adult Patients With Wolfram Syndrome Recruiting NCT02829268 Phase 1, Phase 2 dantrolene sodium
3 GLP Analogs for Diabetes in Wolfram Syndrome Patients Unknown status NCT01302327 Not Applicable Exenatide
4 Predicting Response to Incretin Based Agents in Type 2 Diabetes Completed NCT01503112
5 Wolfram Syndrome International Registry and Clinical Study Recruiting NCT02841553
6 Tracking Neurodegeneration in Early Wolfram Syndrome Active, not recruiting NCT02455414

Search NIH Clinical Center for Wolfram Syndrome 1

Genetic Tests for Wolfram Syndrome 1

Anatomical Context for Wolfram Syndrome 1

MalaCards organs/tissues related to Wolfram Syndrome 1:

41
Brain, Pancreas

Publications for Wolfram Syndrome 1

Articles related to Wolfram Syndrome 1:

(show all 21)
# Title Authors Year
1
Genetic and clinical aspects of Wolfram syndrome 1, a severe neurodegenerative disease. ( 29774890 )
2018
2
Knockdown of wfs1, a fly homolog of Wolfram syndrome 1, in the nervous system increases susceptibility to age- and stress-induced neuronal dysfunction and degeneration in Drosophila. ( 29357349 )
2018
3
Metabolomics of the Wolfram Syndrome 1 Gene (Wfs1) Deficient Mice. ( 29257731 )
2017
4
Exenatide Is an Effective Antihyperglycaemic Agent in a Mouse Model of Wolfram Syndrome 1. ( 27069934 )
2016
5
Early-onset central diabetes insipidus is associated with de novo arginine vasopressin-neurophysin II or Wolfram syndrome 1 gene mutations. ( 25740874 )
2015
6
RETRACTION: Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. ( 25679031 )
2015
7
Sarco(endo)plasmic reticulum ATPase is a molecular partner of Wolfram syndrome 1 protein, which negatively regulates its expression. ( 25274773 )
2014
8
Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation. ( 23903355 )
2013
9
Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability. ( 23035048 )
2013
10
Wolfram syndrome 1 and Wolfram syndrome 2. ( 22790102 )
2012
11
Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. ( 22983116 )
2012
12
Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells. ( 21199859 )
2011
13
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. ( 20160352 )
2010
14
Expression and localization of Wolfram syndrome 1 gene in the developing rat pancreas. ( 19916172 )
2009
15
Wolfram syndrome 1 (Wfs1) mRNA expression in the normal mouse brain during postnatal development. ( 19428703 )
2009
16
Wolfram syndrome 1 (Wfs1) gene expression in the normal mouse visual system. ( 18613120 )
2008
17
Wolfram syndrome 1 (WFS1) protein expression in retinal ganglion cells and optic nerve glia of the cynomolgus monkey. ( 16928372 )
2006
18
The WFS1 (Wolfram syndrome 1) is not a major susceptibility gene for the development of psychiatric disorders. ( 12605098 )
2003
19
Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders. ( 12782971 )
2003
20
WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain. ( 11181571 )
2001
21
Mutations in the Wolfram syndrome 1 gene (WFS1) are a common cause of low frequency sensorineural hearing loss. ( 11709537 )
2001

Variations for Wolfram Syndrome 1

UniProtKB/Swiss-Prot genetic disease variations for Wolfram Syndrome 1:

75 (show all 22)
# Symbol AA change Variation ID SNP ID
1 WFS1 p.Pro504Leu VAR_005842 rs28937892
2 WFS1 p.Gly695Val VAR_005844 rs28937891
3 WFS1 p.Pro724Leu VAR_005845 rs28937890
4 WFS1 p.Glu169Lys VAR_009109 rs148953711
5 WFS1 p.Pro292Ser VAR_009110 rs746923441
6 WFS1 p.Ile296Ser VAR_009111
7 WFS1 p.Gly437Arg VAR_009114 rs147974629
8 WFS1 p.Cys690Arg VAR_009116 rs754373473
9 WFS1 p.Trp700Cys VAR_009117
10 WFS1 p.Gly736Ser VAR_009118 rs71532864
11 WFS1 p.Pro885Leu VAR_009119 rs372855769
12 WFS1 p.Ala58Val VAR_011305 rs369671890
13 WFS1 p.Ala126Thr VAR_011306 rs145639028
14 WFS1 p.Ser443Ile VAR_011308
15 WFS1 p.Gly780Arg VAR_011313
16 WFS1 p.Arg818Cys VAR_011314 rs35932623
17 WFS1 p.Ala133Thr VAR_014034 rs372249044
18 WFS1 p.Tyr669Cys VAR_014038
19 WFS1 p.Tyr110Asn VAR_029499
20 WFS1 p.Arg457Ser VAR_029502 rs113446173
21 WFS1 p.Arg629Trp VAR_029505 rs71530910
22 WFS1 p.Arg558Cys VAR_068343 rs199946797

ClinVar genetic disease variations for Wolfram Syndrome 1:

6
(show all 46)
# Gene Variation Type Significance SNP ID Assembly Location
1 WFS1 WFS1, 2-BP DEL, 2812TC deletion Pathogenic
2 WFS1 WFS1, 15-BP DEL, NT1685 deletion Pathogenic
3 WFS1 NM_006005.3(WFS1): c.2171C> T (p.Pro724Leu) single nucleotide variant Pathogenic rs28937890 GRCh37 Chromosome 4, 6303693: 6303693
4 WFS1 NM_006005.3(WFS1): c.2171C> T (p.Pro724Leu) single nucleotide variant Pathogenic rs28937890 GRCh38 Chromosome 4, 6301966: 6301966
5 WFS1 NM_006005.3(WFS1): c.2084G> T (p.Gly695Val) single nucleotide variant Pathogenic rs28937891 GRCh37 Chromosome 4, 6303606: 6303606
6 WFS1 NM_006005.3(WFS1): c.2084G> T (p.Gly695Val) single nucleotide variant Pathogenic rs28937891 GRCh38 Chromosome 4, 6301879: 6301879
7 WFS1 NM_006005.3(WFS1): c.1944G> A (p.Trp648Ter) single nucleotide variant Pathogenic rs104893879 GRCh37 Chromosome 4, 6303466: 6303466
8 WFS1 NM_006005.3(WFS1): c.1944G> A (p.Trp648Ter) single nucleotide variant Pathogenic rs104893879 GRCh38 Chromosome 4, 6301739: 6301739
9 WFS1 NM_006005.3(WFS1): c.1511C> T (p.Pro504Leu) single nucleotide variant Pathogenic rs28937892 GRCh37 Chromosome 4, 6303033: 6303033
10 WFS1 NM_006005.3(WFS1): c.1511C> T (p.Pro504Leu) single nucleotide variant Pathogenic rs28937892 GRCh38 Chromosome 4, 6301306: 6301306
11 WFS1 WFS1, 7-BP INS, NT1610 insertion Pathogenic
12 WFS1 WFS1, 9-BP DEL, NT1380 deletion Pathogenic
13 WFS1 WFS1, 460, G-A, +1 single nucleotide variant Pathogenic
14 WFS1 NM_006005.3(WFS1): c.676C> T (p.Gln226Ter) single nucleotide variant Pathogenic rs104893880 GRCh37 Chromosome 4, 6293688: 6293688
15 WFS1 NM_006005.3(WFS1): c.676C> T (p.Gln226Ter) single nucleotide variant Pathogenic rs104893880 GRCh38 Chromosome 4, 6291961: 6291961
16 WFS1 NM_006005.3(WFS1): c.2455C> T (p.Gln819Ter) single nucleotide variant Pathogenic rs104893881 GRCh37 Chromosome 4, 6303977: 6303977
17 WFS1 NM_006005.3(WFS1): c.2455C> T (p.Gln819Ter) single nucleotide variant Pathogenic rs104893881 GRCh38 Chromosome 4, 6302250: 6302250
18 WFS1 NM_006005.3(WFS1): c.409_424dup16 (p.Val142Glyfs) duplication Pathogenic rs587776598 GRCh37 Chromosome 4, 6290807: 6290822
19 WFS1 NM_006005.3(WFS1): c.409_424dup16 (p.Val142Glyfs) duplication Pathogenic rs587776598 GRCh38 Chromosome 4, 6289080: 6289095
20 WFS1 WFS1, 16-BP DEL, NT1362 deletion Pathogenic
21 WFS1 NM_006005.3(WFS1): c.2119G> T (p.Val707Phe) single nucleotide variant Pathogenic rs71524377 GRCh37 Chromosome 4, 6303641: 6303641
22 WFS1 NM_006005.3(WFS1): c.2119G> T (p.Val707Phe) single nucleotide variant Pathogenic rs71524377 GRCh38 Chromosome 4, 6301914: 6301914
23 WFS1 WFS1, 8-BP DEL, NT2106 deletion Pathogenic
24 WFS1 NM_006005.3(WFS1): c.2051C> T (p.Ala684Val) single nucleotide variant Pathogenic rs387906930 GRCh37 Chromosome 4, 6303573: 6303573
25 WFS1 NM_006005.3(WFS1): c.2051C> T (p.Ala684Val) single nucleotide variant Pathogenic rs387906930 GRCh38 Chromosome 4, 6301846: 6301846
26 WFS1 WFS1, 3-BP DEL, VAL415DEL deletion Pathogenic
27 WFS1 WFS1, 4-BP DEL, 1387CTCT deletion Pathogenic
28 WFS1 NM_006005.3(WFS1): c.1957C> T (p.Arg653Cys) single nucleotide variant Uncertain significance rs201064551 GRCh37 Chromosome 4, 6303479: 6303479
29 WFS1 NM_006005.3(WFS1): c.1957C> T (p.Arg653Cys) single nucleotide variant Uncertain significance rs201064551 GRCh38 Chromosome 4, 6301752: 6301752
30 WFS1 NM_006005.3(WFS1): c.124C> T (p.Arg42Ter) single nucleotide variant Pathogenic/Likely pathogenic rs71530923 GRCh37 Chromosome 4, 6279306: 6279306
31 WFS1 NM_006005.3(WFS1): c.124C> T (p.Arg42Ter) single nucleotide variant Pathogenic/Likely pathogenic rs71530923 GRCh38 Chromosome 4, 6277579: 6277579
32 WFS1 NM_006005.3(WFS1): c.683G> A (p.Arg228His) single nucleotide variant Uncertain significance rs150771247 GRCh37 Chromosome 4, 6293695: 6293695
33 WFS1 NM_006005.3(WFS1): c.683G> A (p.Arg228His) single nucleotide variant Uncertain significance rs150771247 GRCh38 Chromosome 4, 6291968: 6291968
34 WFS1 NM_006005.3(WFS1): c.1672C> T (p.Arg558Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs199946797 GRCh37 Chromosome 4, 6303194: 6303194
35 WFS1 NM_006005.3(WFS1): c.1672C> T (p.Arg558Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs199946797 GRCh38 Chromosome 4, 6301467: 6301467
36 WFS1 NM_006005.3(WFS1): c.2263T> C (p.Cys755Arg) single nucleotide variant Likely pathogenic rs797045075 GRCh37 Chromosome 4, 6303785: 6303785
37 WFS1 NM_006005.3(WFS1): c.2263T> C (p.Cys755Arg) single nucleotide variant Likely pathogenic rs797045075 GRCh38 Chromosome 4, 6302058: 6302058
38 WFS1 NM_006005.3(WFS1): c.2648_2651delTCTT (p.Phe883Serfs) deletion Pathogenic/Likely pathogenic rs797045076 GRCh37 Chromosome 4, 6304170: 6304173
39 WFS1 NM_006005.3(WFS1): c.2648_2651delTCTT (p.Phe883Serfs) deletion Pathogenic/Likely pathogenic rs797045076 GRCh38 Chromosome 4, 6302443: 6302446
40 WFS1 NM_006005.3(WFS1): c.1060_1062delTTC (p.Phe354del) deletion Pathogenic rs876657735 GRCh38 Chromosome 4, 6300855: 6300857
41 WFS1 NM_006005.3(WFS1): c.1060_1062delTTC (p.Phe354del) deletion Pathogenic rs876657735 GRCh37 Chromosome 4, 6302582: 6302584
42 WFS1 NM_001145853.1(WFS1): c.1079G> A (p.Cys360Tyr) single nucleotide variant Uncertain significance rs147157374 GRCh38 Chromosome 4, 6300874: 6300874
43 WFS1 NM_001145853.1(WFS1): c.1079G> A (p.Cys360Tyr) single nucleotide variant Uncertain significance rs147157374 GRCh37 Chromosome 4, 6302601: 6302601
44 WFS1 NM_001145853.1(WFS1): c.2191A> G (p.Met731Val) single nucleotide variant Uncertain significance rs144010362 GRCh38 Chromosome 4, 6301986: 6301986
45 WFS1 NM_001145853.1(WFS1): c.2191A> G (p.Met731Val) single nucleotide variant Uncertain significance rs144010362 GRCh37 Chromosome 4, 6303713: 6303713
46 HERC2 NC_000015.9: g.28447255A> C single nucleotide variant not provided GRCh37 Chromosome 15, 28447255: 28447255

Expression for Wolfram Syndrome 1

Search GEO for disease gene expression data for Wolfram Syndrome 1.

Pathways for Wolfram Syndrome 1

GO Terms for Wolfram Syndrome 1

Cellular components related to Wolfram Syndrome 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum GO:0005783 9.62 ATF6 HSPA5 SYVN1 WFS1
2 endoplasmic reticulum membrane GO:0005789 9.56 ATF6 HSPA5 SYVN1 WFS1
3 dendrite GO:0030425 9.46 AVP COMT TH WFS1
4 smooth endoplasmic reticulum GO:0005790 9.13 HSPA5 SYVN1 TH
5 integral component of endoplasmic reticulum membrane GO:0030176 8.92 ATF6 HSPA5 SYVN1 WFS1

Biological processes related to Wolfram Syndrome 1 according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.65 ATF6 TH WFS1
2 response to organic cyclic compound GO:0014070 9.61 AVP COMT TH
3 locomotory behavior GO:0007626 9.58 AVP TH
4 response to endoplasmic reticulum stress GO:0034976 9.58 HSPA5 WFS1
5 response to unfolded protein GO:0006986 9.57 ATF6 HSPA5
6 cellular response to drug GO:0035690 9.56 HSPA5 TH
7 positive regulation of protein ubiquitination GO:0031398 9.55 HSPA5 WFS1
8 learning GO:0007612 9.54 COMT TH
9 social behavior GO:0035176 9.52 AVP TH
10 response to nicotine GO:0035094 9.51 AVP TH
11 renal water homeostasis GO:0003091 9.49 AVP WFS1
12 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236 9.46 SYVN1 WFS1
13 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990440 9.4 ATF6 HSPA5
14 ER overload response GO:0006983 9.37 HSPA5 WFS1
15 ubiquitin-dependent ERAD pathway GO:0030433 9.33 HSPA5 SYVN1 WFS1
16 ATF6-mediated unfolded protein response GO:0036500 9.32 ATF6 HSPA5
17 cellular response to manganese ion GO:0071287 9.26 HSPA5 TH
18 IRE1-mediated unfolded protein response GO:0036498 9.13 HSPA5 SYVN1 WFS1
19 endoplasmic reticulum unfolded protein response GO:0030968 8.92 ATF6 HSPA5 SYVN1 WFS1

Molecular functions related to Wolfram Syndrome 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chaperone binding GO:0051087 9.16 HSPA5 SYVN1
2 ATPase binding GO:0051117 8.96 SYVN1 WFS1
3 ubiquitin protein ligase binding GO:0031625 8.8 ATF6 HSPA5 WFS1

Sources for Wolfram Syndrome 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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