MCID: WND001
MIFTS: 31

Wound Botulism

Categories: Neuronal diseases, Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Wound Botulism

MalaCards integrated aliases for Wound Botulism:

Name: Wound Botulism 12 59 15 73
Cutaneous Toxin-Mediated Botulism 59
Cutaneous Infectious Botulism 59
Skin Toxin-Mediated Botulism 59
Skin Infectious Botulism 59
Inoculation Botulism 59

Characteristics:

Orphanet epidemiological data:

59
wound botulism
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages;

Classifications:



Summaries for Wound Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F, which are transmitted by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins.

MalaCards based summary : Wound Botulism, also known as cutaneous toxin-mediated botulism, is related to foodborne botulism and respiratory failure. An important gene associated with Wound Botulism is LY96 (Lymphocyte Antigen 96). Affiliated tissues include skin and testes, and related phenotypes are urinary retention and ptosis

Related Diseases for Wound Botulism

Diseases related to Wound Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 foodborne botulism 32.2 LY96 PAX3
2 respiratory failure 10.0
3 cardiac arrest 9.8
4 tetanus 9.8
5 cellulitis 9.8
6 cranial nerve palsy 9.8
7 cocaine abuse 9.8
8 dysphagia 9.8
9 head injury 9.8
10 intestinal botulism 9.4 FBXW2 LY96
11 infant botulism 9.2 FBXW2 LY96
12 miller-dieker lissencephaly syndrome 9.0 FBXW2 LY96

Graphical network of the top 20 diseases related to Wound Botulism:



Diseases related to Wound Botulism

Symptoms & Phenotypes for Wound Botulism

Human phenotypes related to Wound Botulism:

59 32 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 urinary retention 59 32 frequent (33%) Frequent (79-30%) HP:0000016
2 ptosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000508
3 diplopia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000651
4 dysarthria 59 32 hallmark (90%) Very frequent (99-80%) HP:0001260
5 cardiac arrest 59 32 occasional (7.5%) Occasional (29-5%) HP:0001695
6 fever 59 32 occasional (7.5%) Occasional (29-5%) HP:0001945
7 dysphagia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002015
8 constipation 59 32 hallmark (90%) Very frequent (99-80%) HP:0002019
9 dyspnea 59 32 frequent (33%) Frequent (79-30%) HP:0002094
10 respiratory insufficiency due to muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0002747
11 diaphragmatic paralysis 59 32 hallmark (90%) Very frequent (99-80%) HP:0006597
12 cranial nerve paralysis 59 32 hallmark (90%) Very frequent (99-80%) HP:0006824
13 mydriasis 59 32 hallmark (90%) Very frequent (99-80%) HP:0011499
14 cerebral palsy 59 32 hallmark (90%) Very frequent (99-80%) HP:0100021
15 muscle weakness 59 Very frequent (99-80%)

Drugs & Therapeutics for Wound Botulism

Search Clinical Trials , NIH Clinical Center for Wound Botulism

Genetic Tests for Wound Botulism

Anatomical Context for Wound Botulism

MalaCards organs/tissues related to Wound Botulism:

41
Skin, Testes

Publications for Wound Botulism

Articles related to Wound Botulism:

(show top 50) (show all 83)
# Title Authors Year
1
Wound botulism, its neurological manifestations, treatment and outcomes: A case series from the Glasgow outbreak, 2015. ( 28480790 )
2017
2
Black Tar Heroin Skin Popping as a Cause of Wound Botulism. ( 28569348 )
2017
3
A Case of Localized, Unilateral (Cephalic) Wound Botulism. ( 29293932 )
2017
4
Effective and rapid treatment of wound botulism, a case report. ( 29073888 )
2017
5
Clinical Features of Foodborne and Wound Botulism: A Systematic Review of the Literature, 1932-2015. ( 29293923 )
2017
6
Wound botulism after traumatic open fracture in Italy. ( 26397301 )
2015
7
Draft Genome Sequence of Clostridium botulinum B2 450 Strain from Wound Botulism in a Drug User in Italy. ( 25838491 )
2015
8
Open Tibial Pilon Fracture With Wound Botulism Exacerbated by Aminoglycoside Antibiotic Beads: Case Report. ( 24659304 )
2014
9
Outbreak of wound botulism in people who inject drugs, Norway, October to November 2013. ( 24229788 )
2013
10
Wound botulism resulting from heroin abuse: can you recognize it? ( 21514644 )
2012
11
Wound botulism presenting as a deep neck space infection. ( 22645053 )
2012
12
Recurrent wound botulism among injection drug users in California. ( 21317399 )
2011
13
Wound botulism in drug users: a still underestimated diagnosis. ( 20552239 )
2010
14
Images in clinical medicine: Wound botulism. ( 21158660 )
2010
15
Wound botulism complicating internal fixation of a complex radial fracture. ( 20007390 )
2010
16
Outbreak of wound botulism in injecting drug users. ( 19351433 )
2009
17
Sensitivity of mouse bioassay in clinical wound botulism. ( 19435438 )
2009
18
Wound botulism in injection drug users: time to antitoxin correlates with intensive care unit length of stay. ( 20046244 )
2009
19
Cortical recovery of swallowing function in wound botulism. ( 18462489 )
2008
20
Wound botulism from heroin skin popping. ( 18957182 )
2008
21
Diagnostic pitfall: wound botulism in an intoxicated intravenous drug abuser presenting with respiratory failure. ( 17393137 )
2007
22
First case of type E wound botulism diagnosed using real-time PCR. ( 17881556 )
2007
23
Rapid geographical clustering of wound botulism in Germany after subcutaneous and intramuscular injection of heroin. ( 17356188 )
2007
24
Wound botulism in injection drug users. ( 17582887 )
2007
25
A rare differential diagnosis in dysphagia: wound botulism. ( 16652098 )
2006
26
Wound botulism acquired in the Amazonian rain forest of Ecuador. ( 16606997 )
2006
27
Improvement in laboratory diagnosis of wound botulism and tetanus among injecting illicit-drug users by use of real-time PCR assays for neurotoxin gene fragments. ( 16145075 )
2005
28
Outbreak of wound botulism in injecting drug users in Germany, October-December 2005. ( 16794295 )
2005
29
Wound botulism in injectors of drugs: upsurge in cases in England during 2004. ( 16280612 )
2005
30
Wound botulism. ( 15082850 )
2004
31
Wound botulism in the UK and Ireland. ( 15150338 )
2004
32
Wound botulism in an injecting drug abuser. ( 12682717 )
2003
33
Wound botulism among black tar heroin users--Washington, 2003. ( 13679792 )
2003
34
Early antitoxin treatment in wound botulism results in better outcome. ( 12646758 )
2003
35
[Wound botulism after drug injection]. ( 11821991 )
2002
36
Wound botulism associated with subcutaneous drug use. ( 12411365 )
2002
37
Wound botulism in injecting drug users. ( 11892652 )
2002
38
Wound botulism in the UK. ( 11213130 )
2001
39
Transient paralysis of the bladder due to wound botulism. ( 11464047 )
2001
40
Wound botulism in drug addicts in the United Kingdom. ( 11167471 )
2001
41
Wound botulism associated with black tar heroin and lower extremity cellulitis. ( 11348817 )
2001
42
Clinical predictors of respiratory failure and long-term outcome in black tar heroin-associated wound botulism. ( 11502659 )
2001
43
Botulism in critical care: a case study in wound botulism. ( 11340740 )
2001
44
Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. ( 10773516 )
2000
45
Wound botulism in UK. ( 11130548 )
2000
46
Wound botulism in an injecting drug user in London. ( 10863833 )
2000
47
Wound botulism in California, 1951-1998: recent epidemic in heroin injectors. ( 11049786 )
2000
48
Wound botulism in injecting drug user: second case in England. ( 10905008 )
2000
49
Microbiological investigation into wound botulism. ( 10870286 )
2000
50
Cranial nerve palsies and descending paralysis in a drug abuser resulting from wound botulism. ( 10470586 )
1999

Variations for Wound Botulism

Expression for Wound Botulism

Search GEO for disease gene expression data for Wound Botulism.

Pathways for Wound Botulism

GO Terms for Wound Botulism

Sources for Wound Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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