MCID: WND001
MIFTS: 31

Wound Botulism

Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Wound Botulism

MalaCards integrated aliases for Wound Botulism:

Name: Wound Botulism 12 60 15 74
Cutaneous Toxin-Mediated Botulism 60
Cutaneous Infectious Botulism 60
Skin Toxin-Mediated Botulism 60
Skin Infectious Botulism 60
Inoculation Botulism 60

Characteristics:

Orphanet epidemiological data:

60
wound botulism
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages;

Classifications:



Summaries for Wound Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F, which are transmitted by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins.

MalaCards based summary : Wound Botulism, also known as cutaneous toxin-mediated botulism, is related to foodborne botulism and respiratory failure. An important gene associated with Wound Botulism is LY96 (Lymphocyte Antigen 96). Affiliated tissues include skin, eye and testes, and related phenotypes are ptosis and diplopia

Related Diseases for Wound Botulism

Diseases related to Wound Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 foodborne botulism 33.0 LY96 PAX3
2 respiratory failure 10.1
3 cardiac arrest 10.0
4 tetanus 10.0
5 cellulitis 10.0
6 cocaine abuse 10.0
7 dysphagia 10.0
8 head injury 10.0
9 intestinal botulism 9.7 FBXW2 LY96
10 infant botulism 9.6 FBXW2 LY96
11 miller-dieker lissencephaly syndrome 9.5 FBXW2 LY96

Graphical network of the top 20 diseases related to Wound Botulism:



Diseases related to Wound Botulism

Symptoms & Phenotypes for Wound Botulism

Human phenotypes related to Wound Botulism:

60 33 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 60 33 hallmark (90%) Very frequent (99-80%) HP:0000508
2 diplopia 60 33 hallmark (90%) Very frequent (99-80%) HP:0000651
3 dysarthria 60 33 hallmark (90%) Very frequent (99-80%) HP:0001260
4 dysphagia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002015
5 constipation 60 33 hallmark (90%) Very frequent (99-80%) HP:0002019
6 cranial nerve paralysis 60 33 hallmark (90%) Very frequent (99-80%) HP:0006824
7 cerebral palsy 60 33 hallmark (90%) Very frequent (99-80%) HP:0100021
8 diaphragmatic paralysis 60 33 hallmark (90%) Very frequent (99-80%) HP:0006597
9 mydriasis 60 33 hallmark (90%) Very frequent (99-80%) HP:0011499
10 dyspnea 60 33 frequent (33%) Frequent (79-30%) HP:0002094
11 respiratory insufficiency due to muscle weakness 60 33 frequent (33%) Frequent (79-30%) HP:0002747
12 urinary retention 60 33 frequent (33%) Frequent (79-30%) HP:0000016
13 fever 60 33 occasional (7.5%) Occasional (29-5%) HP:0001945
14 cardiac arrest 60 33 occasional (7.5%) Occasional (29-5%) HP:0001695
15 muscle weakness 60 Very frequent (99-80%)

Drugs & Therapeutics for Wound Botulism

Search Clinical Trials , NIH Clinical Center for Wound Botulism

Genetic Tests for Wound Botulism

Anatomical Context for Wound Botulism

MalaCards organs/tissues related to Wound Botulism:

42
Skin, Eye, Testes

Publications for Wound Botulism

Articles related to Wound Botulism:

(show top 50) (show all 89)
# Title Authors Year
1
Wound Botulism Outbreak Among Persons Who Use Black Tar Heroin - San Diego County, California, 2017-2018. ( 30605447 )
2019
2
Wound Botulism Outbreak. ( 30747972 )
2019
3
Is black tar heroin use associated with wound botulism? A report of two Hispanic patients. ( 29988706 )
2018
4
A pragmatic harm reduction approach to manage a large outbreak of wound botulism in people who inject drugs, Scotland 2015. ( 29996865 )
2018
5
Wound botulism caused by Clostridium subterminale after a heroin injection. ( 30344967 )
2018
6
Wound botulism, its neurological manifestations, treatment and outcomes: A case series from the Glasgow outbreak, 2015. ( 28480790 )
2017
7
Black Tar Heroin Skin Popping as a Cause of Wound Botulism. ( 28569348 )
2017
8
A Case of Localized, Unilateral (Cephalic) Wound Botulism. ( 29293932 )
2017
9
Effective and rapid treatment of wound botulism, a case report. ( 29073888 )
2017
10
Clinical Features of Foodborne and Wound Botulism: A Systematic Review of the Literature, 1932-2015. ( 29293923 )
2017
11
Wound botulism after traumatic open fracture in Italy. ( 26397301 )
2015
12
Draft Genome Sequence of Clostridium botulinum B2 450 Strain from Wound Botulism in a Drug User in Italy. ( 25838491 )
2015
13
Open Tibial Pilon Fracture With Wound Botulism Exacerbated by Aminoglycoside Antibiotic Beads: Case Report. ( 24659304 )
2014
14
Outbreak of wound botulism in people who inject drugs, Norway, October to November 2013. ( 24229788 )
2013
15
Wound botulism resulting from heroin abuse: can you recognize it? ( 21514644 )
2012
16
Wound botulism presenting as a deep neck space infection. ( 22645053 )
2012
17
Recurrent wound botulism among injection drug users in California. ( 21317399 )
2011
18
Wound botulism in drug users: a still underestimated diagnosis. ( 20552239 )
2010
19
Images in clinical medicine: Wound botulism. ( 21158660 )
2010
20
Wound botulism complicating internal fixation of a complex radial fracture. ( 20007390 )
2010
21
Outbreak of wound botulism in injecting drug users. ( 19351433 )
2009
22
Sensitivity of mouse bioassay in clinical wound botulism. ( 19435438 )
2009
23
Wound botulism in injection drug users: time to antitoxin correlates with intensive care unit length of stay. ( 20046244 )
2009
24
Cortical recovery of swallowing function in wound botulism. ( 18462489 )
2008
25
Wound botulism from heroin skin popping. ( 18957182 )
2008
26
Diagnostic pitfall: wound botulism in an intoxicated intravenous drug abuser presenting with respiratory failure. ( 17393137 )
2007
27
First case of type E wound botulism diagnosed using real-time PCR. ( 17881556 )
2007
28
Rapid geographical clustering of wound botulism in Germany after subcutaneous and intramuscular injection of heroin. ( 17356188 )
2007
29
Wound botulism in injection drug users. ( 17582887 )
2007
30
A rare differential diagnosis in dysphagia: wound botulism. ( 16652098 )
2006
31
Wound botulism acquired in the Amazonian rain forest of Ecuador. ( 16606997 )
2006
32
Improvement in laboratory diagnosis of wound botulism and tetanus among injecting illicit-drug users by use of real-time PCR assays for neurotoxin gene fragments. ( 16145075 )
2005
33
Outbreak of wound botulism in injecting drug users in Germany, October-December 2005. ( 16794295 )
2005
34
Wound botulism in injectors of drugs: upsurge in cases in England during 2004. ( 16280612 )
2005
35
Wound botulism in injectors of drugs: upsurge in cases in England during 2004. ( 29208132 )
2005
36
Wound botulism. ( 15082850 )
2004
37
Wound botulism in the UK and Ireland. ( 15150338 )
2004
38
Wound botulism in an injecting drug abuser. ( 12682717 )
2003
39
Wound botulism among black tar heroin users--Washington, 2003. ( 13679792 )
2003
40
Early antitoxin treatment in wound botulism results in better outcome. ( 12646758 )
2003
41
[Wound botulism after drug injection]. ( 11821991 )
2002
42
Wound botulism associated with subcutaneous drug use. ( 12411365 )
2002
43
Wound botulism in injecting drug users. ( 11892652 )
2002
44
Wound botulism in the UK. ( 11213130 )
2001
45
Transient paralysis of the bladder due to wound botulism. ( 11464047 )
2001
46
Wound botulism in drug addicts in the United Kingdom. ( 11167471 )
2001
47
Wound botulism associated with black tar heroin and lower extremity cellulitis. ( 11348817 )
2001
48
Clinical predictors of respiratory failure and long-term outcome in black tar heroin-associated wound botulism. ( 11502659 )
2001
49
Botulism in critical care: a case study in wound botulism. ( 11340740 )
2001
50
Cardiac arrest due to succinylcholine-induced hyperkalemia in a patient with wound botulism. ( 10773516 )
2000

Variations for Wound Botulism

Expression for Wound Botulism

Search GEO for disease gene expression data for Wound Botulism.

Pathways for Wound Botulism

GO Terms for Wound Botulism

Sources for Wound Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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