MCID: WND001
MIFTS: 35

Wound Botulism

Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Wound Botulism

MalaCards integrated aliases for Wound Botulism:

Name: Wound Botulism 12 58 15 71
Cutaneous Toxin-Mediated Botulism 58
Cutaneous Infectious Botulism 58
Skin Toxin-Mediated Botulism 58
Skin Infectious Botulism 58
Inoculation Botulism 58

Characteristics:

Orphanet epidemiological data:

58
wound botulism
Prevalence: 1-9/1000000 (Europe); Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050353
ICD10 via Orphanet 33 A05.1
UMLS via Orphanet 72 C1306794
Orphanet 58 ORPHA178475
UMLS 71 C1306794

Summaries for Wound Botulism

Disease Ontology : 12 A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F, which are transmitted by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins.

MalaCards based summary : Wound Botulism, also known as cutaneous toxin-mediated botulism, is related to foodborne botulism and infant botulism. An important gene associated with Wound Botulism is GPA33 (Glycoprotein A33), and among its related pathways/superpathways are Neuroscience and Uptake and actions of bacterial toxins. Affiliated tissues include skin and eye, and related phenotypes are ptosis and diplopia

Related Diseases for Wound Botulism

Graphical network of the top 20 diseases related to Wound Botulism:



Diseases related to Wound Botulism

Symptoms & Phenotypes for Wound Botulism

Human phenotypes related to Wound Botulism:

58 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000508
2 diplopia 58 31 hallmark (90%) Very frequent (99-80%) HP:0000651
3 dysarthria 58 31 hallmark (90%) Very frequent (99-80%) HP:0001260
4 dysphagia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002015
5 constipation 58 31 hallmark (90%) Very frequent (99-80%) HP:0002019
6 cranial nerve paralysis 58 31 hallmark (90%) Very frequent (99-80%) HP:0006824
7 cerebral palsy 58 31 hallmark (90%) Very frequent (99-80%) HP:0100021
8 diaphragmatic paralysis 58 31 hallmark (90%) Very frequent (99-80%) HP:0006597
9 mydriasis 58 31 hallmark (90%) Very frequent (99-80%) HP:0011499
10 respiratory insufficiency due to muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0002747
11 dyspnea 58 31 frequent (33%) Frequent (79-30%) HP:0002094
12 urinary retention 58 31 frequent (33%) Frequent (79-30%) HP:0000016
13 fever 58 31 occasional (7.5%) Occasional (29-5%) HP:0001945
14 cardiac arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0001695
15 muscle weakness 58 Very frequent (99-80%)

Drugs & Therapeutics for Wound Botulism

Search Clinical Trials , NIH Clinical Center for Wound Botulism

Genetic Tests for Wound Botulism

Anatomical Context for Wound Botulism

MalaCards organs/tissues related to Wound Botulism:

40
Skin, Eye

Publications for Wound Botulism

Articles related to Wound Botulism:

(show top 50) (show all 163)
# Title Authors PMID Year
1
CRISPR-Cas9-Based Toolkit for Clostridium botulinum Group II Spore and Sporulation Research. 61
33584620 2021
2
Re: The dilemma of diagnosing wound botulism in an infant. 61
33340665 2020
3
Dysphagia Alone as a Unique Presentation of Wound Botulism in the Emergency Department: A Case Report. 61
33217286 2020
4
Toxemia in Human Naturally Acquired Botulism. 61
33202855 2020
5
Diversity of the Genomes and Neurotoxins of Strains of Clostridium botulinum Group I and Clostridium sporogenes Associated with Foodborne, Infant and Wound Botulism. 61
32932818 2020
6
Wound Botulism Caused by Botulinum Neurotoxin Type A in a Chronic Parenteral Drug Abuser. 61
33362521 2020
7
The dilemma of diagnosing wound botulism in an infant: A rare case of paralysis with topical application of honey. 61
32220630 2020
8
Wound botulism presenting as dysphagia to an ENT ward. 61
32051157 2020
9
Adult Intestinal Toxemia Botulism. 61
31991691 2020
10
Lambert-Eaton Myasthenic Syndrome, Botulism, and Immune Checkpoint Inhibitor-Related Myasthenia Gravis. 61
31794471 2019
11
Needle in a Haystack: A Missed Case of Wound Botulism. 61
30951679 2019
12
Medical treatment for botulism. 61
30993666 2019
13
Prevalence of complications associated with use of the Henderson equine castrating instrument. 61
29926934 2019
14
Wound Botulism Outbreak. 61
30747972 2019
15
Botulism - a rare but still present, life-threatening disease. 61
31181950 2019
16
Wound Botulism Outbreak Among Persons Who Use Black Tar Heroin - San Diego County, California, 2017-2018. 61
30605447 2019
17
Tetanus, Botulism, and Diphtheria. 61
30273248 2018
18
Wound botulism caused by Clostridium subterminale after a heroin injection. 61
30344967 2018
19
Is black tar heroin use associated with wound botulism? A report of two Hispanic patients. 61
29988706 2018
20
A pragmatic harm reduction approach to manage a large outbreak of wound botulism in people who inject drugs, Scotland 2015. 61
29996865 2018
21
Identification of Cross Reactive Antigens of C. botulinum Types A, B, E & F by Immunoproteomic Approach. 61
29332140 2018
22
Shot by a Gun … Missed by a Provider. 61
29449118 2018
23
Clinical Features of Foodborne and Wound Botulism: A Systematic Review of the Literature, 1932-2015. 61
29293923 2017
24
A Case of Localized, Unilateral (Cephalic) Wound Botulism. 61
29293932 2017
25
Black Tar Heroin Skin Popping as a Cause of Wound Botulism. 61
28569348 2017
26
Wound botulism, its neurological manifestations, treatment and outcomes: A case series from the Glasgow outbreak, 2015. 61
28480790 2017
27
Effective and rapid treatment of wound botulism, a case report. 61
29073888 2017
28
[Botulism: Diagnosis and Therapy]. 61
28850968 2017
29
Cranial Neuropathies and Neuromuscular Weakness: A Case of Mistaken Identity. 61
29849352 2017
30
A Case of a 34-Year-Old Female with Acute Hypoxemic Respiratory Failure and Proximal Muscle Weakness. 61
29410923 2017
31
Prevalence and correlates of neck injection among people who inject drugs in Tijuana, Mexico. 61
25867795 2015
32
[Intoxication of botulinum toxin]. 61
26449577 2015
33
Wound botulism after traumatic open fracture in Italy. 61
26397301 2015
34
Draft Genome Sequence of Clostridium botulinum B2 450 Strain from Wound Botulism in a Drug User in Italy. 61
25838491 2015
35
Botulism mortality in the USA, 1975-2009. 61
28603554 2015
36
View from the front lines: an emergency medicine perspective on clostridial infections in injection drug users. 61
25230330 2014
37
Open Tibial Pilon Fracture With Wound Botulism Exacerbated by Aminoglycoside Antibiotic Beads: Case Report. 61
24659304 2014
38
[Traumatic wound botulism]. 61
24584800 2014
39
Medical treatment for botulism. 61
24558013 2014
40
Outbreak of wound botulism in people who inject drugs, Norway, October to November 2013. 61
24229788 2013
41
Variable ptosis after botulinum toxin type a injection with positive ice test mimicking ocular myasthenia gravis. 61
23681240 2013
42
Genetic diversity within Clostridium botulinum serotypes, botulinum neurotoxin gene clusters and toxin subtypes. 61
23239346 2013
43
Acute neuromuscular weakness in a boy with a facial abscess contaminated with Clostridium botulinum. 61
22935869 2012
44
Wound botulism presenting as a deep neck space infection. 61
22645053 2012
45
Rapid and selective detection of botulinum neurotoxin serotype-A and -B with a single immunochromatographic test strip. 61
22504369 2012
46
Wound botulism resulting from heroin abuse: can you recognize it? 61
21514644 2012
47
Chronic Clostridium botulinum infections in farmers. 61
22197952 2012
48
Rare case of dysphagia. 61
20809173 2011
49
[Practice of botulism]. 61
21747147 2011
50
Recurrent wound botulism among injection drug users in California. 61
21317399 2011

Variations for Wound Botulism

Expression for Wound Botulism

Search GEO for disease gene expression data for Wound Botulism.

Pathways for Wound Botulism

GO Terms for Wound Botulism

Cellular components related to Wound Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.62 VAPA VAMP2 VAMP1 SV2A
2 neuron projection GO:0043005 9.54 VAMP2 VAMP1 SV2A
3 azurophil granule membrane GO:0035577 9.26 VAPA VAMP1
4 SNARE complex GO:0031201 9.16 VAMP2 VAMP1
5 integral component of synaptic vesicle membrane GO:0030285 8.96 VAMP1 SV2A
6 synaptic vesicle membrane GO:0030672 8.8 VAMP2 VAMP1 SV2A

Biological processes related to Wound Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane fusion GO:0061025 9.16 VAPA VAMP2
2 vesicle fusion GO:0006906 8.96 VAMP2 VAMP1
3 SNARE complex assembly GO:0035493 8.62 VAMP2 VAMP1

Molecular functions related to Wound Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 syntaxin binding GO:0019905 8.96 VAMP2 VAMP1
2 SNAP receptor activity GO:0005484 8.62 VAMP2 VAMP1

Sources for Wound Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....