Aliases & Classifications for Wrinkles

MalaCards integrated aliases for Wrinkles:

Name: Wrinkles 38

Summaries for Wrinkles

MalaCards based summary : Wrinkles is related to cutis laxa and cutis laxa, autosomal dominant 1. An important gene associated with Wrinkles is ALDH18A1 (Aldehyde Dehydrogenase 18 Family Member A1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Pathways in cancer. The drugs Acetylcholine and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and bone.

Wikipedia : 76 A wrinkle, also known as a rhytide, is a fold, ridge or crease in the skin or on fabric. Skin wrinkles... more...

Related Diseases for Wrinkles

Diseases related to Wrinkles via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 cutis laxa 32.0 ALDH18A1 ELN
2 cutis laxa, autosomal dominant 1 31.8 ALDH18A1 ELN
3 autosomal recessive cutis laxa type iii 31.5 ALDH18A1 ELN
4 heart disease 29.2 ELN LPL VEGFA
5 macroepiphyseal dysplasia with osteoporosis, wrinkled skin, and aged appearance 12.1
6 wrinkly skin syndrome 11.6
7 microcephalic primordial dwarfism, montreal type 11.6
8 aquagenic syringeal acrokeratoderm 11.3
9 megarbane-jalkh syndrome 11.2
10 cutis laxa, autosomal dominant 3 11.1
11 cantu sanchez-corona hernandez syndrome 11.0
12 prune belly syndrome 11.0
13 beare-stevenson cutis gyrata syndrome 11.0
14 ehlers-danlos syndrome, musculocontractural type, 1 11.0
15 ehlers-danlos syndrome, spondylodysplastic type, 3 11.0
16 cutis laxa, autosomal recessive, type iic 11.0
17 cutis laxa, autosomal recessive, type iid 11.0
18 autosomal recessive cutis laxa type i 11.0
19 lenz-majewski hyperostotic dwarfism 10.9
20 elsahy-waters syndrome 10.9
21 cutis laxa, autosomal recessive, type ia 10.9
22 cutis laxa, autosomal recessive, type iia 10.9
23 gapo syndrome 10.9
24 geroderma osteodysplasticum 10.9
25 miller-dieker lissencephaly syndrome 10.9
26 ogden syndrome 10.9
27 fontaine progeroid syndrome 10.9
28 cutis laxa, autosomal recessive, type iib 10.9
29 cutis laxa, autosomal recessive, type ic 10.9
30 autosomal recessive cutis laxa type ii classic type 10.9
31 cholera 10.9
32 uveal disease 10.9
33 geroderma osteodysplastica 10.9
34 granulomatous slack skin disease 10.9
35 pachygyria 10.9
36 progeroid syndrome petty type 10.9
37 aging 10.5
38 cystic fibrosis 10.3
39 neuropathy 10.1
40 critical limb ischemia 10.0 HGF VEGFA
41 limb ischemia 10.0 HGF VEGFA
42 earlobe crease 10.0
43 osteoporosis 10.0
44 keratoconus 10.0
45 ptosis 10.0
46 headache 10.0
47 mid-dermal elastolysis 10.0
48 isolated optic neuritis 10.0
49 chronic myocardial ischemia 10.0 HGF VEGFA
50 optic disk drusen 10.0 ELN VEGFA

Graphical network of the top 20 diseases related to Wrinkles:



Diseases related to Wrinkles

Symptoms & Phenotypes for Wrinkles

Drugs & Therapeutics for Wrinkles

Drugs for Wrinkles (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 151)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Not Applicable 51-84-3 187
2
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 9004-61-9 53477741
3
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 137-58-6 3676
4
Mannitol Approved, Investigational Phase 4,Not Applicable 69-65-8 453 6251
5
Kinetin Approved Phase 4 525-79-1 3830
6
Ethanol Approved Phase 4,Phase 3,Not Applicable 64-17-5 702
7
Tocopherol Approved, Investigational Phase 4,Not Applicable 1406-66-2 14986
8
Polidocanol Approved Phase 4 9002-92-0
9
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
10
Aminolevulinic acid Approved Phase 4,Phase 3,Not Applicable 106-60-5 137
11
Tetracaine Approved, Vet_approved Phase 4,Phase 3 94-24-6 5411
12 tannic acid Approved Phase 4
13
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
14
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 65-23-6 1054
15
Tretinoin Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 302-79-4 5538 444795
16
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 59-02-9 14985
17
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
18
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 11103-57-4, 68-26-8 445354
19 Tocotrienol Investigational Phase 4,Not Applicable 6829-55-6
20 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Not Applicable
21 Botulinum Toxins, Type A Phase 4,Phase 2,Phase 3,Not Applicable
22 Cholinergic Agents Phase 4,Phase 2,Phase 3,Not Applicable
23 Botulinum Toxins Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Acetylcholine Release Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
26 onabotulinumtoxinA Phase 4,Phase 2,Phase 3,Not Applicable
27 abobotulinumtoxinA Phase 4,Phase 2,Phase 3,Not Applicable
28 Neuromuscular Agents Phase 4,Phase 2,Phase 3,Not Applicable
29 incobotulinumtoxinA Phase 4,Phase 3,Phase 2,Not Applicable
30 Ophthalmic Solutions Phase 4
31 Viscosupplements Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
32 Adjuvants, Immunologic Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
33 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
34 Anesthetics Phase 4,Phase 3,Phase 2,Not Applicable
35 Anesthetics, Local Phase 4,Phase 3,Not Applicable
36 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
37 Proxymetacaine Phase 4
38 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
39 Immunologic Factors Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
40 Anti-Arrhythmia Agents Phase 4,Phase 3,Not Applicable
41 Diuretics, Potassium Sparing Phase 4,Phase 3,Not Applicable
42 Sodium Channel Blockers Phase 4,Phase 3,Not Applicable
43 Antioxidants Phase 4,Phase 2,Phase 1,Not Applicable
44 Vitamins Phase 4,Phase 2,Phase 1,Not Applicable
45 Natriuretic Agents Phase 4,Not Applicable
46 diuretics Phase 4,Not Applicable
47 Keratolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
48 Dermatologic Agents Phase 4,Phase 3,Phase 2,Not Applicable
49 Micronutrients Phase 4,Phase 2,Phase 1,Not Applicable
50 Trace Elements Phase 4,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 406)
# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of the Full Face Applications of Variable Doses of a Commercial Botulinum Toxin Type a (Dysport®) Unknown status NCT01032954 Phase 4 Botulinum toxin
2 Comparison of Escalating Doses of IncobotulinumtoxinA (Xeomin®) in the Treatment of Glabellar Rhytids Unknown status NCT01583478 Phase 4
3 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Unknown status NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
4 Injection Assistance Device Versus Manual Injections for Delivery of Dermal Fillers Unknown status NCT01492140 Phase 4
5 A Clinical Study Comparing Restylane® Silk and Belotero Balance® for the Treatment of Superficial, Vertical Perioral Lines Unknown status NCT02818556 Phase 4 Restalyne Silk;Belotero Balance
6 Study of Restylane and Perlane in the Correction of Peri-Oral Wrinkles Completed NCT00977704 Phase 4
7 Perception of Facial Expressions Following Correction of Wrinkles and Folds Completed NCT02573337 Phase 4
8 TEOSYAL® PureSense Redensity [I] Injection Using MicronJet® Needle in the Treatment of Crow's Feet Wrinkles Completed NCT02497846 Phase 4
9 Study of BOTOX and JUVEDERM for Treatment of Moderate to Severe Facial Wrinkles and Folds Completed NCT01269801 Phase 4 onabotulinumtoxinA;JUVÉDERM
10 Emervel for the Correction of Lower Face Wrinkles & Folds Completed NCT02718040 Phase 4
11 Ablative Fractional Lasers to Treat Peri-orbital Rhytides Completed NCT00990431 Phase 4
12 Treatment With Botulinum Toxin Type A (BOTOX®) in Chinese Patients With Moderate to Severe Frown Lines Completed NCT01814670 Phase 4
13 Comparison of Outcome Parameters in Laser Rhytide Treatment Completed NCT00994474 Phase 4
14 Clinical Trial on a Topical "Antiage" Face Gel Completed NCT01948531 Phase 4 Gynomunal® gel
15 Phase Iv Study On Muscle Activity Of Two Commercial Preparations Of Botulinum Completed NCT01728337 Phase 4 Dysport;Xeomin
16 A Study of Subject Satisfaction With BOTOX® Cosmetic Treatment in Facial Rhytides Completed NCT01777620 Phase 4 Normal Saline
17 Comparison of Two Commercial Preparations of Botulinum Toxin Type A Completed NCT00959907 Phase 4 BOTULINUM TOXIN TYPE-A
18 Comparative Study of the Effect of Dysport and Botox Completed NCT00434863 Phase 4 botulinum toxin type A
19 Fractional CO2 Treatment of Acne Scars in Asians Completed NCT00748462 Phase 4
20 Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A Completed NCT00989768 Phase 4 Botulinum Toxin Type A (Dysport®);Botulinum Toxin Type A/Botox®;Botulinum Toxin Type A/Dysport®
21 Fields Of Effects Of Two Commercial Preparations Of Botulinum Toxin Type A At Equal Labeled Unit Doses Completed NCT01732809 Phase 4 group A;group B
22 Radial Diffusion of the Botulinum Toxin Type A (Botox®): Electromyographic Evaluation of the Frontal Muscle Completed NCT01297634 Phase 4 Botulinum Toxin Type-A (day 0);Botulinum Toxin Type-A (day 0);Botulinum Toxin Type-A (day 0)
23 The Treatment of Glabellar Frown Lines Completed NCT02096081 Phase 4 IncobotulinumtoxinA;OnabotulinumtoxinA
24 A Post-Market Study to Evaluate Adverse Event Incidence Rates in Patients With Skin of Color Undergoing Correction of Nasolabial Folds With Hylaform, Hylaform Plus and Captique. Completed NCT00293163 Phase 4
25 Patient Satisfaction Study of BOTOX® Cosmetic in the Treatment of Moderate to Severe Frown Lines Completed NCT01391312 Phase 4 normal saline (placebo)
26 Non-comparative Evaluation of Facial Expressions Following Lower Face Correction Using Emervel Classic and Emervel Deep Completed NCT02672644 Phase 4
27 A Study to Determine How Long Restylane® Will Last After Initial Treatment With 2 Different Re-treatment Schedules. Completed NCT00765583 Phase 4 Restylane
28 Post Market Safety Study and Effectiveness With Evolence in Subjects With Skin Color Types IV-VI Completed NCT00891774 Phase 4
29 A Trial of Skin Care Protocols for Facial Resurfacing Completed NCT01113606 Phase 4
30 Poly-L-lactic Acid for Skin Quality Completed NCT02003833 Phase 4
31 Safety and Efficacy of Two Types of Botulinum Toxin Type A For the Treatment of Glabellar Lines Completed NCT01271452 Phase 4
32 Comparative Study of Reconstituted JUVÉDERM® Ultra vs COSMODERM® 1 for Lip and Cheek Lines, Folds or Wrinkles Completed NCT01212809 Phase 4
33 Non-inferiority of Belotero® Basic Versus Juvéderm® Ultra 3 Completed NCT01305187 Phase 4
34 Comparison of Dysport Reconstitution at 1.5 mL and 2.5 mL for the Treatment of Moderate to Severe Glabellar Lines Completed NCT02718118 Phase 4
35 Study to Evaluate the Effect of a Nu Skin Product and Device for Brown Spots Completed NCT01149876 Phase 4 Tretinoin cream 0.05
36 A Study to Assess the Effects of an Oral Dietary Supplement on Overall Facial Appearance Among Healthy Adult Women With Existing Skin Damage From Sun Exposure Completed NCT01787461 Phase 4
37 Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler Completed NCT01012661 Phase 4
38 Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color Completed NCT01012388 Phase 4
39 Onabotulinum Toxin Type A and Abobotulinum Toxin Type A Crow's Feet Rhytid Study Completed NCT01529788 Phase 4 Right lateral orbital injection of Botox Cosmetic or Dysport;Left lateral orbital injection of Botox Cosmetic or Dysport
40 Evaluation Onset Time of DWP450-004 and Safety in Moderate-severe Glabellar Lines Completed NCT02568150 Phase 4
41 Efficacy and Safety of Kinetin 0.1% for Treatment of Skin Photoaging Completed NCT01898182 Phase 4
42 Retinol on Human Skin Aging in East Asian Descent Completed NCT02906566 Phase 4 Retinol;Placebo
43 Botox Cosmetic and the Young Patient With Glabellar Furrows Completed NCT00856999 Phase 4 Botox
44 (Macrolane VR30) in Buttocks Reshaping and contouringCellulite (Macrolane VR30) in Buttocks Reshaping and Contouring Completed NCT02127723 Phase 4
45 Patient Satisfaction Study of Combined Facial Treatment With BOTOX® Cosmetic, JUVÉDERM® and LATISSE® (HARMONY Study) Completed NCT02176356 Phase 4 bimatoprost ophthalmic solution 0.03%
46 A Multi-center Long Term Efficacy Trial of the GFX For Reduction of Glabellar Furrowing Completed NCT00611273 Phase 4
47 Upper Facial Remodeling With Perlane-L and Dysport Completed NCT01354743 Phase 4 Dysport
48 Effect of Revival Soy on Weight Loss and Skin, Hair, and Nails in Premenopausal Women Completed NCT00352157 Phase 4
49 Efficacy and Safety Study of Kinerase® for Treatment of Cutaneous Facial Photodamage Completed NCT01885091 Phase 4
50 Safety and Efficacy of Azzalure/Dysport, Restylane/Emervel Filler and Restylane Skinbooster Treatment Completed NCT02297516 Phase 4 Azzalure or Dysport

Search NIH Clinical Center for Wrinkles

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Wrinkles cell therapies at LifeMap Discovery.

Genetic Tests for Wrinkles

Anatomical Context for Wrinkles

MalaCards organs/tissues related to Wrinkles:

41
Skin, Eye, Bone, Testes, Ovary, Heart, B Cells

Publications for Wrinkles

Articles related to Wrinkles:

(show top 50) (show all 564)
# Title Authors Year
1
Lamellipodial wrinkles in fish keratocytes as markers of imperfect coordination between extension and retraction during cell migration. ( 29530529 )
2018
2
OnabotulinumtoxinA and Hyaluronic Acid in Facial Wrinkles and Folds: A Prospective, Open-Label Comparison. ( 29762642 )
2018
3
Single-Center, Double-Blind, Randomized, Placebo-Controlled, Study of the Efficacy and Safety of a Cream Formulation for Improving Facial Wrinkles and Skin Quality. ( 29879254 )
2018
4
Botulinum toxin type A for wrinkles: the least interesting use of this versatile protein. ( 29785814 )
2018
5
Shear Rheology Control of Wrinkles and Patterns in Graphene Oxide Films. ( 29463083 )
2018
6
Universal Method for Creating Hierarchical Wrinkles on Thin-Film Surfaces. ( 29179552 )
2018
7
Usefulness of Monopolar Thermal Radiofrequency Treatment for Periorbital Wrinkles. ( 29853743 )
2018
8
Responsive and Adaptive Micro Wrinkles on Organic-inorganic Hybrid Materials. ( 29688632 )
2018
9
A healthy diet in women is associated with less facial wrinkles in a large Dutch population-based cohort. ( 29601935 )
2018
10
Dual wavelength treatment protocol with a picosecond laser for the reduction of facial wrinkles. ( 29883215 )
2018
11
Using normal and high pulse coverage with picosecond laser treatment of wrinkles and acne scarring: Long term clinical observations. ( 29140537 )
2018
12
Evolution of local wrinkles near defects on stiff film/compliant substrate. ( 29546675 )
2018
13
On skin microrelief and the emergence of expression micro-wrinkles. ( 29319711 )
2018
14
Wrinkles and creases in the bending, unbending and eversion of soft sectors. ( 29740258 )
2018
15
Proposed global drooping and wrinkles classification and scoring system for aging face with validation and experience on 54 Indian subjects. ( 29873312 )
2018
16
Writing Wrinkles on Poly(dimethylsiloxane) (PDMS) by Surface Oxidation with a CO<sub>2</sub>Laser Engraver. ( 29302968 )
2018
17
Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration. ( 29574973 )
2018
18
Wedge-shaped polydioxanone threads in a folded configuration (&amp;quot;Solid fillers&amp;quot;): A treatment option for deep static wrinkles on the upper face. ( 29673044 )
2018
19
Facial Wrinkles in Europeans: AA Genome-Wide Association Study. ( 29555444 )
2018
20
Dermapen in the treatment of wrinkles in cigarette smokers and skin aging effectively. ( 30549208 )
2018
21
Formation of high aspect ratio wrinkles and ridges on elastic bilayers with small thickness contrast. ( 30338335 )
2018
22
Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration. ( 30375189 )
2018
23
Cosmetic benefit of a biomimetic lamellar cream formulation on barrier function or the appearance of fine lines and wrinkles in randomised proof-of-concept clinical studies. ( 30414275 )
2018
24
Active wrinkles to drive self-cleaning: A strategy for anti-thrombotic surfaces for vascular grafts. ( 30458358 )
2018
25
Coenzyme Q10 and retinaldehyde co-loaded nanostructured lipid carriers for efficacy evaluation in wrinkles. ( 28895754 )
2018
26
Novel Topical Cytokinin Improves Coarse Wrinkles and Skin Roughness Without Skin Irritation. ( 30005100 )
2018
27
Multipolydioxanone scaffold improves upper lip and forehead wrinkles: A 12-month outcome. ( 30009511 )
2018
28
Wrinkles, brown spots, and cancer: Relationship between appearance- and health-based knowledge and sunscreen use. ( 30009555 )
2018
29
Clear aligners' effects on aesthetics: evaluation of facial wrinkles. ( 30057713 )
2018
30
Intradermal Injection of Botulinum Toxin: A Safer Treatment Modality for Forehead Wrinkles. ( 30065587 )
2018
31
Efficacy and safety of long pulse Nd:YAG laser versus fractional erbium:YAG laser in the treatment of facial skin wrinkles. ( 30117052 )
2018
32
Smoothening of wrinkles in CVD-grown hexagonal boron nitride films. ( 30124699 )
2018
33
Nitrogen plasma skin regeneration for the treatment of mild-to-moderate periorbital wrinkles: A prospective, randomized, controlled evaluator-blinded trial. ( 30146783 )
2018
34
Achieving high aspect ratio wrinkles by modifying material network stress. ( 28555680 )
2017
35
Corrigendum to &amp;quot;Topical application of neem leaves prevents wrinkles formation in UVB-exposed hairless mice&amp;quot; [J. Photochem. Photobiol. B Biol. 169 (April 2017) 161-170]. ( 28965841 )
2017
36
Bio-inspired hierarchical micro- and nano-wrinkles obtained via mechanically directed self-assembly on shape-memory polymers. ( 28504298 )
2017
37
Hyaluronic acid microneedle patch for the improvement of crow's feet wrinkles. ( 28892233 )
2017
38
The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles. ( 28392646 )
2017
39
Effect of thread embedding acupuncture for facial wrinkles and laxity: a single-arm, prospective, open-label study. ( 29296569 )
2017
40
Oblique wrinkles. ( 28373381 )
2017
41
Multimodal Approach for Treating Horizontal Neck Wrinkles Using Intensity Focused Ultrasound, Cohesive Polydensified Matrix Hyaluronic Acid, and IncobotulinumtoxinA. ( 28902030 )
2017
42
The smectic order of wrinkles. ( 28719599 )
2017
43
YouTube Videos on Botulinum Toxin A for Wrinkles: A Useful Resource for Patient Education. ( 28877151 )
2017
44
Classification of facial wrinkles among Chinese women. ( 28808192 )
2017
45
Treatment of periorbital wrinkles using multipolar fractional radiofrequency in Korean patients. ( 27686890 )
2017
46
Corrigendum: The Effect of Micro-Spicule Containing Epidermal Growth Factor on Periocular Wrinkles. ( 29200788 )
2017
47
Self-similar Hierarchical Wrinkles as a Potential Multifunctional Smart Window with Simultaneously Tunable Transparency, Structural Color, and Droplet Transport. ( 28702991 )
2017
48
Buckling patterns in biaxially pre-stretched bilayer shells: wrinkles, creases, folds and fracture-like ridges. ( 29044284 )
2017
49
Dynamic pattern of wrinkles in a dielectric elastomer. ( 28357441 )
2017
50
Comparison of the Clinical Efficacy of Abobotulinumtoxin A (ABO) and Onabotulinumtoxin A (ONA) in the Treatment of Crow's Feet Wrinkles: A Split-Face Study. ( 29278961 )
2017

Variations for Wrinkles

Expression for Wrinkles

Search GEO for disease gene expression data for Wrinkles.

Pathways for Wrinkles

GO Terms for Wrinkles

Cellular components related to Wrinkles according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 CSF3 HGF LPL PDGFA VEGFA
2 extracellular region GO:0005576 9.43 CSF3 ELN HGF LPL PDGFA VEGFA
3 platelet alpha granule lumen GO:0031093 8.8 HGF PDGFA VEGFA

Biological processes related to Wrinkles according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.63 CSF3 HGF VEGFA
2 positive regulation of cell migration GO:0030335 9.61 HGF PDGFA VEGFA
3 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.55 CSF3 VEGFA
4 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.54 HGF VEGFA
5 positive regulation of MAP kinase activity GO:0043406 9.52 PDGFA VEGFA
6 outflow tract morphogenesis GO:0003151 9.51 ELN VEGFA
7 positive regulation of protein kinase B signaling GO:0051897 9.5 CSF3 HGF PDGFA
8 positive chemotaxis GO:0050918 9.49 HGF VEGFA
9 positive regulation of cell division GO:0051781 9.48 PDGFA VEGFA
10 regulation of signaling receptor activity GO:0010469 9.46 CSF3 HGF PDGFA VEGFA
11 platelet degranulation GO:0002576 9.43 HGF PDGFA VEGFA
12 positive regulation of mesenchymal cell proliferation GO:0002053 9.4 PDGFA VEGFA
13 positive regulation of protein autophosphorylation GO:0031954 9.37 PDGFA VEGFA
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.13 CSF3 HGF VEGFA
15 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 8.8 CSF3 HGF PDGFA

Molecular functions related to Wrinkles according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.54 HGF PDGFA VEGFA
2 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.32 HGF PDGFA
3 chemoattractant activity GO:0042056 9.26 HGF VEGFA
4 extracellular matrix binding GO:0050840 9.16 ELN VEGFA
5 platelet-derived growth factor receptor binding GO:0005161 8.96 PDGFA VEGFA
6 growth factor activity GO:0008083 8.92 CSF3 HGF PDGFA VEGFA

Sources for Wrinkles

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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