IMD74
MCID: XLN245
MIFTS: 13

X-Linked Immunodeficiency 74 (IMD74)

Categories: Genetic diseases, Immune diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for X-Linked Immunodeficiency 74

MalaCards integrated aliases for X-Linked Immunodeficiency 74:

Name: X-Linked Immunodeficiency 74 12
Respiratory Insufficiency Due to Sars-Cov-2 Viral Infection 12
X-Linked Immunodeficiency 74,covid-19-Related 12
Tlr7 Deficiency 12
Imd74 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0112063

Summaries for X-Linked Immunodeficiency 74

Disease Ontology : 12 A T cell deficiency characterized by severe respiratory insufficiency in response to infection with the COVID19 coronavirus and impaired signaling through the TLR7 pathway that has material basis in hemizygous mutation in TLR7 on chromosome Xp22.2.

MalaCards based summary : X-Linked Immunodeficiency 74, also known as respiratory insufficiency due to sars-cov-2 viral infection, is related to immunodeficiency 74, covid19-related, x-linked and microvascular complications of diabetes 5. Affiliated tissues include b cells.

Related Diseases for X-Linked Immunodeficiency 74

Diseases related to X-Linked Immunodeficiency 74 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 immunodeficiency 74, covid19-related, x-linked 11.4
2 microvascular complications of diabetes 5 9.9
3 japanese encephalitis 9.9
4 retinal vascular disease 9.9

Symptoms & Phenotypes for X-Linked Immunodeficiency 74

Drugs & Therapeutics for X-Linked Immunodeficiency 74

Search Clinical Trials , NIH Clinical Center for X-Linked Immunodeficiency 74

Genetic Tests for X-Linked Immunodeficiency 74

Anatomical Context for X-Linked Immunodeficiency 74

MalaCards organs/tissues related to X-Linked Immunodeficiency 74:

40
B Cells

Publications for X-Linked Immunodeficiency 74

Articles related to X-Linked Immunodeficiency 74:

(show all 19)
# Title Authors PMID Year
1
Toll-like receptor 7 deficiency suppresses type 1 diabetes development by modulating B-cell differentiation and function. 61
33432061 2021
2
TLR7 Negatively Regulates B10 Cells Predominantly in an IFN╬│ Signaling Dependent Manner. 61
32849556 2020
3
Toll-like receptor 7 deficiency promotes survival and reduces adverse left ventricular remodelling after myocardial infarction. 61
30830156 2019
4
Toll-Like Receptor 7 Enhances Rabies Virus-Induced Humoral Immunity by Facilitating the Formation of Germinal Centers. 61
30906301 2019
5
TLR7 deficiency contributes to attenuated diabetic retinopathy via inhibition of inflammatory response. 61
28843858 2017
6
Toll-like receptor 7 deficiency protects apolipoprotein E-deficient mice from diet-induced atherosclerosis. 61
28405010 2017
7
TLR7 Deficiency Leads to TLR8 Compensative Regulation of Immune Response against JEV in Mice. 61
28265274 2017
8
Toll-like Receptor 7 Is Reduced in Severe Asthma and Linked to an Altered MicroRNA Profile. 61
26815632 2016
9
Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells. 61
26803634 2016
10
B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers. 61
25252960 2014
11
Evaluating the role of nucleic acid antigens in murine models of systemic lupus erythematosus. 61
24957237 2014
12
TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice. 61
24474776 2014
13
Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice. 61
23561801 2013
14
Toll-like receptor 7 suppresses virus replication in neurons but does not affect viral pathogenesis in a mouse model of Langat virus infection. 61
23136362 2013
15
Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance. 61
22691272 2012
16
Respiratory virus-induced TLR7 activation controls IL-17-associated increased mucus via IL-23 regulation. 61
20624950 2010
17
Interactions between TLR7 and TLR9 agonists and receptors regulate innate immune responses by astrocytes and microglia. 61
19998480 2010
18
TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus. 61
20089701 2010
19
Toll-like receptor-dependent immune complex activation of B cells and dendritic cells. 61
19378022 2009

Variations for X-Linked Immunodeficiency 74

Expression for X-Linked Immunodeficiency 74

Search GEO for disease gene expression data for X-Linked Immunodeficiency 74.

Pathways for X-Linked Immunodeficiency 74

GO Terms for X-Linked Immunodeficiency 74

Sources for X-Linked Immunodeficiency 74

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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